Shivashankar Othy

Title(s)Assistant Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6754
ORCID ORCID Icon0000-0001-6832-5547 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines. Commun Biol. 2024 Aug 28; 7(1):1059. Manville RW, Yoshimura RF, Yeromin AV, Hogenkamp D, van der Horst J, Zavala A, Chinedu S, Arena G, Lasky E, Fisher M, Tracy CR, Othy S, Jepps TA, Cahalan MD, Abbott GW. PMID: 39198706; PMCID: PMC11358443.
      View in: PubMed   Mentions: Translation:HumansAnimals
    2. Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function. bioRxiv. 2024 Jul 04. Ifejeokwu OV, Do A, El Khatib SM, Ho NH, Zavala A, Othy S, Acharya MM. PMID: 39005282; PMCID: PMC11244914.
      View in: PubMed   Mentions:
    3. Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the efficacy of PD-1 immunotherapy. Cancer Cell. 2024 Jun 10; 42(6):1051-1066.e7. Geels SN, Moshensky A, Sousa RS, Murat C, Bustos MA, Walker BL, Singh R, Harbour SN, Gutierrez G, Hwang M, Mempel TR, Weaver CT, Nie Q, Hoon DSB, Ganesan AK, Othy S, Marangoni F. PMID: 38861924; PMCID: PMC11285091.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis. Sci Adv. 2023 07 07; 9(27):eadd9984. Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt JM, Farahat PK, Nguyen Q, Pervolarakis N, McLinden K, Thurlow L, Movahedi S, Hughes BS, Duarte J, Sorn A, Montoya E, Mozaffar I, Dragan M, Othy S, Joshi T, Hans CP, Kimonis V, MacLean AL, Nie Q, Wallace LM, Harper SQ, Mozaffar T, Hogarth MW, Bhattacharya S, Jaiswal JK, Golann DR, Su Q, Kessenbrock K, Stec M, Spencer MJ, Zamudio JR, Villalta SA. PMID: 37418531; PMCID: PMC10328414.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    5. Interruption of the Intratumor CD8:Treg Crosstalk Improves the Efficacy of PD-1 Immunotherapy. bioRxiv. 2023 May 18. Geels SN, Moshensky A, Sousa RS, Walker BL, Singh R, Gutierrez G, Hwang M, Mempel TR, Nie Q, Othy S, Marangoni F. PMID: 37292782; PMCID: PMC10245792.
      View in: PubMed   Mentions:
    6. Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis. bioRxiv. 2023 Apr 18. Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt JM, Farahat PK, Nguyen Q, Pervolarakis N, McLinden K, Thurlow L, Movahedi S, Duarte J, Sorn A, Montoya E, Mozaffar I, Dragan M, Othy S, Joshi T, Hans CP, Kimonis V, MacLean AL, Nie Q, Wallace LM, Harper SQ, Mozaffar T, Hogarth MW, Bhattacharya S, Jaiswal JK, Golann DR, Su Q, Kessenbrock K, Stec M, Spencer MJ, Zamudio JR, Villalta SA. PMID: 37131694; PMCID: PMC10153153.
      View in: PubMed   Mentions:
    7. Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses. Cell Rep. 2022 03 29; 38(13):110600. Bolton JL, Short AK, Othy S, Kooiker CL, Shao M, Gunn BG, Beck J, Bai X, Law SM, Savage JC, Lambert JJ, Belelli D, Tremblay MÈ, Cahalan MD, Baram TZ. PMID: 35354026; PMCID: PMC9014810.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    8. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife. 2022 02 22; 11. Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M, Cahalan MD. PMID: 35191835; PMCID: PMC8906810.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    9. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci Adv. 2021 07; 7(28). Jairaman A, Othy S, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Marangoni F, Parker I, Pathak MM, Cahalan MD. PMID: 34233878; PMCID: PMC8262815.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    10. Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell. 2021 07 22; 184(15):3998-4015.e19. Marangoni F, Zhakyp A, Corsini M, Geels SN, Carrizosa E, Thelen M, Mani V, Prüßmann JN, Warner RD, Ozga AJ, Di Pilato M, Othy S, Mempel TR. PMID: 34157302; PMCID: PMC8664158.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    11. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021 05 31; 12(1):3256. Atcha H, Jairaman A, Holt JR, Meli VS, Nagalla RR, Veerasubramanian PK, Brumm KT, Lim HE, Othy S, Cahalan MD, Pathak MM, Liu WF. PMID: 34059671; PMCID: PMC8167181.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    12. Calcium Dynamics in Astrocytes During Cell Injury. Front Bioeng Biotechnol. 2020; 8:912. Wakida NM, Gomez-Godinez V, Li H, Nguyen J, Kim EK, Dynes JL, Othy S, Lau AL, Ding P, Shi L, Carmona C, Thompson LM, Cahalan MD, Berns MW. PMID: 32984268; PMCID: PMC7481337.
      View in: PubMed   Mentions: 9  
    13. Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20088-20099. Othy S, Jairaman A, Dynes JL, Dong TX, Tune C, Yeromin AV, Zavala A, Akunwafo C, Chen F, Parker I, Cahalan MD. PMID: 32732436; PMCID: PMC7443932.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    14. Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant. Neurobiol Dis. 2020 07; 140:104868. McIntyre LL, Greilach SA, Othy S, Sears-Kraxberger I, Wi B, Ayala-Angulo J, Vu E, Pham Q, Silva J, Dang K, Rezk F, Steward O, Cahalan MD, Lane TE, Walsh CM. PMID: 32276110; PMCID: PMC7253332.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    15. Cxcl17-/- mice develop exacerbated disease in a T cell-dependent autoimmune model. J Leukoc Biol. 2019 05; 105(5):1027-1039. Hernández-Ruiz M, Othy S, Herrera C, Nguyen HT, Arrevillaga-Boni G, Catalan-Dibene J, Cahalan MD, Zlotnik A. PMID: 30860634; PMCID: PMC8279723.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife. 2017 12 14; 6. Dong TX, Othy S, Greenberg ML, Jairaman A, Akunwafo C, Leverrier S, Yu Y, Parker I, Dynes JL, Cahalan MD. PMID: 29239723; PMCID: PMC5747518.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    17. T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse. Elife. 2017 12 14; 6. Dong TX, Othy S, Jairaman A, Skupsky J, Zavala A, Parker I, Dynes JL, Cahalan MD. PMID: 29239725; PMCID: PMC5747524.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    18. Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun. 2015 Feb 05; 6:6219. Matheu MP, Othy S, Greenberg ML, Dong TX, Schuijs M, Deswarte K, Hammad H, Lambrecht BN, Parker I, Cahalan MD. PMID: 25653051; PMCID: PMC4347855.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    19. Sialylation may be dispensable for reciprocal modulation of helper T cells by intravenous immunoglobulin. Eur J Immunol. 2014 Jul; 44(7):2059-63. Othy S, Topçu S, Saha C, Kothapalli P, Lacroix-Desmazes S, Käsermann F, Miescher S, Bayry J, Kaveri SV. PMID: 24700174.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    20. Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis. J Immunol. 2013 May 01; 190(9):4535-41. Othy S, Hegde P, Topçu S, Sharma M, Maddur MS, Lacroix-Desmazes S, Bayry J, Kaveri SV. PMID: 23526819.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    21. Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):E2412-3; author reply E2414. Othy S, Topçu S, Kaveri SV, Bayry J. PMID: 22864916; PMCID: PMC3443131.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: role of lipid accumulation. J Autoimmun. 2012 Sep; 39(3):168-72. Othy S, Bruneval P, Topçu S, Dugail I, Delers F, Lacroix-Desmazes S, Bayry J, Kaveri SV. PMID: 22704540.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. Immunomodulation by intravenous immunoglobulin: role of regulatory T cells. J Clin Immunol. 2010 May; 30 Suppl 1:S4-8. Maddur MS, Othy S, Hegde P, Vani J, Lacroix-Desmazes S, Bayry J, Kaveri SV. PMID: 20405183.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
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