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Demetriou, Michael

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentNeurology
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-9775
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of human immune modulation by oral N-acetylglucosamine
    NIH/NCCIH R01AT007452Jun 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Impaired T cell immunity in the Elderly via enhanced N-glycosylation.
    NIH/NIAID R01AI108917Dec 15, 2013 - Nov 30, 2018
    Role: Principal Investigator
    Human Autoimmunity and Genetic Defects in N-Glycosylation
    NIH/NIAID R01AI082266Feb 1, 2010 - Jan 31, 2014
    Role: Principal Investigator
    Multiple Sclerosis and Genetic Defects in N-Glycosylation
    NIH/NIAID R56AI082266Jun 1, 2009 - Jan 31, 2010
    Role: Principal Investigator
    T cell regulation by N-glycosylation
    NIH/NIAID R01AI053331Dec 1, 2002 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tran MH, Mkhikian H, Sy M, Perez-Alvarez I, Demetriou M. Long-term plasma exchange as maintenance therapy for cerebellar-type Hashimoto's encephalopathy, a case report. Transfus Apher Sci. 2018 May 29. PMID: 29891220.
      View in: PubMed
    2. Araujo L, Khim P, Mkhikian H, Mortales CL, Demetriou M. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. Elife. 2017 Jan 06; 6. PMID: 28059703.
      View in: PubMed
    3. Mkhikian H, Mortales CL, Zhou RW, Khachikyan K, Wu G, Haslam SM, Kavarian P, Dell A, Demetriou M. Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. Elife. 2016 06 08; 5. PMID: 27269286; PMCID: PMC4940165.
    4. Yu Z, Demetriou M, Gillen DL. Genome-Wide Analysis of Gene-Gene and Gene-Environment Interactions Using Closed-Form Wald Tests. Genet Epidemiol. 2015 Sep; 39(6):446-55. PMID: 26095143; PMCID: PMC4544597.
    5. Zhou RW, Mkhikian H, Grigorian A, Hong A, Chen D, Arakelyan A, Demetriou M. N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²? signaling. Nat Immunol. 2014 Nov; 15(11):1038-45. PMID: 25263124.
      View in: PubMed
    6. Williams R, Ma X, Schott RK, Mohammad N, Ho CY, Li CF, Chang BS, Demetriou M, Dennis JW. Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution. PLoS One. 2014; 9(1):e86088. PMID: 24475074; PMCID: PMC3901687.
    7. Li CF, Zhou RW, Mkhikian H, Newton BL, Yu Z, Demetriou M. Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants. J Neuroimmunol. 2013 Mar 15; 256(1-2):71-6. PMID: 23351704; PMCID: PMC4528623.
    8. Yu Z, Gillen D, Li CF, Demetriou M. Incorporating parental information into family-based association tests. Biostatistics. 2013 Jul; 14(3):556-72. PMID: 23266418; PMCID: PMC3732025.
    9. Grigorian A, Mkhikian H, Li CF, Newton BL, Zhou RW, Demetriou M. Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation. Semin Immunopathol. 2012 May; 34(3):415-24. PMID: 22488447; PMCID: PMC3960996.
    10. Grigorian A, Mkhikian H, Demetriou M. Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation. Ann N Y Acad Sci. 2012 Apr; 1253:49-57. PMID: 22288682; PMCID: PMC4520414.
    11. Grigorian A, Araujo L, Naidu NN, Place DJ, Choudhury B, Demetriou M. N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis. J Biol Chem. 2011 Nov 18; 286(46):40133-41. PMID: 21965673; PMCID: PMC3220534.
    12. Bahaie NS, Kang BN, Frenzel EM, Hosseinkhani MR, Ge XN, Greenberg Y, Ha SG, Demetriou M, Rao SP, Sriramarao P. N-Glycans differentially regulate eosinophil and neutrophil recruitment during allergic airway inflammation. J Biol Chem. 2011 Nov 04; 286(44):38231-41. PMID: 21911487; PMCID: PMC3207438.
    13. Grigorian A, Demetriou M. Mgat5 deficiency in T cells and experimental autoimmune encephalomyelitis. ISRN Neurol. 2011; 2011:374314. PMID: 22389815; PMCID: PMC3263545.
    14. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334. PMID: 21629267; PMCID: PMC3133923.
    15. Kölln J, Zhang Y, Thai G, Demetriou M, Hermanowicz N, Duquette P, van den Noort S, Qin Y. Inhibition of glyceraldehyde-3-phosphate dehydrogenase activity by antibodies present in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol. 2010 Aug 01; 185(3):1968-75. PMID: 20610654.
      View in: PubMed
    16. Grigorian A, Demetriou M. Manipulating cell surface glycoproteins by targeting N-glycan-galectin interactions. Methods Enzymol. 2010; 480:245-66. PMID: 20816213.
      View in: PubMed
    17. Dennis JW, Nabi IR, Demetriou M. Metabolism, cell surface organization, and disease. Cell. 2009 Dec 24; 139(7):1229-41. PMID: 20064370; PMCID: PMC3065826.
    18. Dennis JW, Lau KS, Demetriou M, Nabi IR. Adaptive regulation at the cell surface by N-glycosylation. Traffic. 2009 Nov; 10(11):1569-78. PMID: 19761541.
      View in: PubMed
    19. Chen HL, Li CF, Grigorian A, Tian W, Demetriou M. T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching. J Biol Chem. 2009 Nov 20; 284(47):32454-61. PMID: 19706602; PMCID: PMC2781660.
    20. Grigorian A, Torossian S, Demetriou M. T-cell growth, cell surface organization, and the galectin-glycoprotein lattice. Immunol Rev. 2009 Jul; 230(1):232-46. PMID: 19594640; PMCID: PMC3059806.
    21. Chen IJ, Chen HL, Demetriou M. Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling. J Biol Chem. 2007 Nov 30; 282(48):35361-72. PMID: 17897956.
      View in: PubMed
    22. Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, Mozaffar T, McKerlie C, Demetriou M. N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem. 2007 Nov 16; 282(46):33725-34. PMID: 17855338.
      View in: PubMed
    23. Grigorian A, Lee SU, Tian W, Chen IJ, Gao G, Mendelsohn R, Dennis JW, Demetriou M. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem. 2007 Jul 06; 282(27):20027-35. PMID: 17488719.
      View in: PubMed
    24. Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW. Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell. 2007 Apr 06; 129(1):123-34. PMID: 17418791.
      View in: PubMed
    25. Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, Li B. N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol. 2004 Dec 15; 173(12):7200-8. PMID: 15585841.
      View in: PubMed
    26. Dennis JW, Pawling J, Cheung P, Partridge E, Demetriou M. UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6 N-acetylglucosaminyltransferase V (Mgat5) deficient mice. Biochim Biophys Acta. 2002 Dec 19; 1573(3):414-22. PMID: 12417426.
      View in: PubMed
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