Michael Demetriou

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9775
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    Collapse Research 
    Collapse Research Activities and Funding
    Cancer Immunotherapy Targeting Tn Antigen
    NIH R41CA261408Aug 1, 2021 - Jul 31, 2022
    Role: Principal Investigator
    Regulation of B cell function in demyelinating disease by N-glycan branching
    NIH R01AI144403Jan 14, 2019 - Dec 31, 2023
    Role: Principal Investigator
    N-glycosylation and Immunotherapy for cancer
    NIH U01CA233078Sep 21, 2018 - Aug 31, 2023
    Role: Principal Investigator
    O-Glycan-dependent Immunotherapy for Cancer
    NIH R41CA233111Sep 18, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Institutional Career Development Core
    NIH KL2TR001416Aug 15, 2015 - Jun 30, 2024
    Role: Co-Principal Investigator
    Mechanisms of human immune modulation by oral N-acetylglucosamine
    NIH R01AT007452Jun 1, 2014 - May 31, 2020
    Role: Principal Investigator
    Impaired T cell immunity in the Elderly via enhanced N-glycosylation.
    NIH R01AI108917Dec 15, 2013 - Nov 30, 2019
    Role: Principal Investigator
    Human Autoimmunity and Genetic Defects in N-Glycosylation
    NIH R01AI082266Feb 1, 2010 - Jan 31, 2015
    Role: Principal Investigator
    Multiple Sclerosis and Genetic Defects in N-Glycosylation
    NIH R56AI082266Jun 1, 2009 - Jan 31, 2010
    Role: Principal Investigator
    T cell regulation by N-glycosylation
    NIH R01AI053331Dec 1, 2002 - Apr 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial. J Neuroinflammation. 2023 Sep 13; 20(1):209. Sy M, Newton BL, Pawling J, Hayama KL, Cordon A, Yu Z, Kuhle J, Dennis JW, Brandt AU, Demetriou M. PMID: 37705084; PMCID: PMC10498575.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    2. T cell senescence by N-glycan branching. Aging (Albany NY). 2022 08 13; 14(15):5964-5965. Mkhikian H, Demetriou M. PMID: 35963641; PMCID: PMC9417233.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching. Nat Aging. 2022 03; 2(3):231-242. Mkhikian H, Hayama KL, Khachikyan K, Li C, Zhou RW, Pawling J, Klaus S, Tran PQN, Ly KM, Gong AD, Saryan H, Hai JL, Grigoryan D, Lee PL, Newton BL, Raffatellu M, Dennis JW, Demetriou M. PMID: 35528547; PMCID: PMC9075523.
      View in: PubMed   Mentions: 7  Translation:HumansAnimalsCells
    4. Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration. JAMA Neurol. 2021 07 01; 78(7):842-852. Brandt AU, Sy M, Bellmann-Strobl J, Newton BL, Pawling J, Zimmermann HG, Yu Z, Chien C, Dörr J, Wuerfel JT, Dennis JW, Paul F, Demetriou M. PMID: 33970182; PMCID: PMC8111565.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    5. N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation. J Biol Chem. 2020 12 18; 295(51):17413-17424. Sy M, Brandt AU, Lee SU, Newton BL, Pawling J, Golzar A, Rahman AMA, Yu Z, Cooper G, Scheel M, Paul F, Dennis JW, Demetriou M. PMID: 33453988; PMCID: PMC7762951.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    6. Effect of vitamin D supplementation on N-glycan branching and cellular immunophenotypes in MS. Ann Clin Transl Neurol. 2020 09; 7(9):1628-1641. Bäcker-Koduah P, Infante-Duarte C, Ivaldi F, Uccelli A, Bellmann-Strobl J, Wernecke KD, Sy M, Demetriou M, Dörr J, Paul F, Ulrich Brandt A. PMID: 32830462; PMCID: PMC7480923.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination. iScience. 2020 Aug 21; 23(8):101380. Mortales CL, Lee SU, Manousadjian A, Hayama KL, Demetriou M. PMID: 32745987; PMCID: PMC7398982.
      View in: PubMed   Mentions: 12  
    8. N-Glycan Branching Is Required for Development of Mature B Cells. J Immunol. 2020 08 01; 205(3):630-636. Mortales CL, Lee SU, Demetriou M. PMID: 32591389; PMCID: PMC7417207.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    9. Increasing cell permeability of N-acetylglucosamine via 6-acetylation enhances capacity to suppress T-helper 1 (TH1)/TH17 responses and autoimmunity. PLoS One. 2019; 14(3):e0214253. Lee SU, Li CF, Mortales CL, Pawling J, Dennis JW, Grigorian A, Demetriou M. PMID: 30913278; PMCID: PMC6435169.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells. Stem Cell Reports. 2018 10 09; 11(4):869-882. Yale AR, Nourse JL, Lee KR, Ahmed SN, Arulmoli J, Jiang AYL, McDonnell LP, Botten GA, Lee AP, Monuki ES, Demetriou M, Flanagan LA. PMID: 30197120; PMCID: PMC6178213.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    11. Long-term plasma exchange as maintenance therapy for cerebellar-type Hashimoto's encephalopathy, a case report. Transfus Apher Sci. 2018 Jun; 57(3):418-420. Tran MH, Mkhikian H, Sy M, Perez-Alvarez I, Demetriou M. PMID: 29891220.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation. Elife. 2017 01 06; 6. Araujo L, Khim P, Mkhikian H, Mortales CL, Demetriou M. PMID: 28059703; PMCID: PMC5257256.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    13. Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. Elife. 2016 06 08; 5. Mkhikian H, Mortales CL, Zhou RW, Khachikyan K, Wu G, Haslam SM, Kavarian P, Dell A, Demetriou M. PMID: 27269286; PMCID: PMC4940165.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    14. Quantifying the origin of metallic glass formation. Nat Commun. 2016 Jan 20; 7:10313. Johnson WL, Na JH, Demetriou MD. PMID: 26786966; PMCID: PMC4735709.
      View in: PubMed   Mentions: 11     Fields:    
    15. Genome-Wide Analysis of Gene-Gene and Gene-Environment Interactions Using Closed-Form Wald Tests. Genet Epidemiol. 2015 Sep; 39(6):446-55. Yu Z, Demetriou M, Gillen DL. PMID: 26095143; PMCID: PMC4544597.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    16. N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling. Nat Immunol. 2014 Nov; 15(11):1038-45. Zhou RW, Mkhikian H, Grigorian A, Hong A, Chen D, Arakelyan A, Demetriou M. PMID: 25263124.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    17. Membrane biophysics define neuron and astrocyte progenitors in the neural lineage. Stem Cells. 2014 Mar; 32(3):706-16. Nourse JL, Prieto JL, Dickson AR, Lu J, Pathak MM, Tombola F, Demetriou M, Lee AP, Flanagan LA. PMID: 24105912; PMCID: PMC5367858.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    18. Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms. Genes Immun. 2014 Apr; 15(4):218-23. Yu Z, Li CF, Mkhikian H, Zhou RW, Newton BL, Demetriou M. PMID: 24572742; PMCID: PMC4047175.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Encoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolution. PLoS One. 2014; 9(1):e86088. Williams R, Ma X, Schott RK, Mohammad N, Ho CY, Li CF, Chang BS, Demetriou M, Dennis JW. PMID: 24475074; PMCID: PMC3901687.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants. J Neuroimmunol. 2013 Mar 15; 256(1-2):71-6. Li CF, Zhou RW, Mkhikian H, Newton BL, Yu Z, Demetriou M. PMID: 23351704; PMCID: PMC4528623.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    21. Incorporating parental information into family-based association tests. Biostatistics. 2013 Jul; 14(3):556-72. Yu Z, Gillen D, Li CF, Demetriou M. PMID: 23266418; PMCID: PMC3732025.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation. Semin Immunopathol. 2012 May; 34(3):415-24. Grigorian A, Mkhikian H, Li CF, Newton BL, Zhou RW, Demetriou M. PMID: 22488447; PMCID: PMC3960996.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation. Ann N Y Acad Sci. 2012 Apr; 1253:49-57. Grigorian A, Mkhikian H, Demetriou M. PMID: 22288682; PMCID: PMC4520414.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    24. N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis. J Biol Chem. 2011 Nov 18; 286(46):40133-41. Grigorian A, Araujo L, Naidu NN, Place DJ, Choudhury B, Demetriou M. PMID: 21965673; PMCID: PMC3220534.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    25. N-Glycans differentially regulate eosinophil and neutrophil recruitment during allergic airway inflammation. J Biol Chem. 2011 Nov 04; 286(44):38231-38241. Bahaie NS, Kang BN, Frenzel EM, Hosseinkhani MR, Ge XN, Greenberg Y, Ha SG, Demetriou M, Rao SP, Sriramarao P. PMID: 21911487; PMCID: PMC3207438.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    26. Mgat5 deficiency in T cells and experimental autoimmune encephalomyelitis. ISRN Neurol. 2011; 2011:374314. Grigorian A, Demetriou M. PMID: 22389815; PMCID: PMC3263545.
      View in: PubMed   Mentions: 13  
    27. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. PMID: 21629267; PMCID: PMC3133923.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    28. Inhibition of glyceraldehyde-3-phosphate dehydrogenase activity by antibodies present in the cerebrospinal fluid of patients with multiple sclerosis. J Immunol. 2010 Aug 01; 185(3):1968-75. Kölln J, Zhang Y, Thai G, Demetriou M, Hermanowicz N, Duquette P, van den Noort S, Qin Y. PMID: 20610654.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Manipulating cell surface glycoproteins by targeting N-glycan-galectin interactions. Methods Enzymol. 2010; 480:245-66. Grigorian A, Demetriou M. PMID: 20816213.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    30. Metabolism, cell surface organization, and disease. Cell. 2009 Dec 24; 139(7):1229-41. Dennis JW, Nabi IR, Demetriou M. PMID: 20064370; PMCID: PMC3065826.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    31. Adaptive regulation at the cell surface by N-glycosylation. Traffic. 2009 Nov; 10(11):1569-78. Dennis JW, Lau KS, Demetriou M, Nabi IR. PMID: 19761541.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    32. T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching. J Biol Chem. 2009 Nov 20; 284(47):32454-61. Chen HL, Li CF, Grigorian A, Tian W, Demetriou M. PMID: 19706602; PMCID: PMC2781660.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    33. T-cell growth, cell surface organization, and the galectin-glycoprotein lattice. Immunol Rev. 2009 Jul; 230(1):232-46. Grigorian A, Torossian S, Demetriou M. PMID: 19594640; PMCID: PMC3059806.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    34. Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling. J Biol Chem. 2007 Nov 30; 282(48):35361-72. Chen IJ, Chen HL, Demetriou M. PMID: 17897956.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    35. N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration. J Biol Chem. 2007 Nov 16; 282(46):33725-33734. Lee SU, Grigorian A, Pawling J, Chen IJ, Gao G, Mozaffar T, McKerlie C, Demetriou M. PMID: 17855338.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    36. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem. 2007 Jul 06; 282(27):20027-35. Grigorian A, Lee SU, Tian W, Chen IJ, Gao G, Mendelsohn R, Dennis JW, Demetriou M. PMID: 17488719.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    37. Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell. 2007 Apr 06; 129(1):123-34. Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW. PMID: 17418791.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansAnimalsCells
    38. N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol. 2004 Dec 15; 173(12):7200-8. Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, Li B. PMID: 15585841.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
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