Medha Pathak

Title(s)Assistant Professor, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6623
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    Collapse Research 
    Collapse Research Activities and Funding
    Building the brain: How mechanical forces shape human neural development
    NIH DP2AT010376Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Piezo1 in neural stem cell mechano-regulation
    NIH R01NS109810Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    MechBio 2018: The Mechanome in Action
    NIH R13GM130052Jul 25, 2018 - Jul 24, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci Adv. 2021 Jul; 7(28). Jairaman A, Othy S, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Marangoni F, Parker I, Pathak MM, Cahalan MD. PMID: 34233878.
      View in: PubMed   Mentions:    Fields:    
    2. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021 05 31; 12(1):3256. Atcha H, Jairaman A, Holt JR, Meli VS, Nagalla RR, Veerasubramanian PK, Brumm KT, Lim HE, Othy S, Cahalan MD, Pathak MM, Liu WF. PMID: 34059671.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Mechanobiology of neural development. Curr Opin Cell Biol. 2020 10; 66:104-111. Abuwarda H, Pathak MM. PMID: 32687993.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers. Commun Biol. 2019; 2:298. Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. PMID: 31396578.
      View in: PubMed   Mentions:
    5. Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance. Front Endocrinol (Lausanne). 2019; 10:373. Zhao C, Sun Q, Tang L, Cao Y, Nourse JL, Pathak MM, Lu X, Yang Q. PMID: 31263454.
      View in: PubMed   Mentions:
    6. How cells channel their stress: Interplay between Piezo1 and the cytoskeleton. Semin Cell Dev Biol. 2017 11; 71:3-12. Nourse JL, Pathak MM. PMID: 28676421.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    7. The Hv1 proton channel responds to mechanical stimuli. J Gen Physiol. 2016 11; 148(5):405-418. Pathak MM, Tran T, Hong L, Joós B, Morris CE, Tombola F. PMID: 27799320.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. PMID: 27475528.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    9. Reflectin as a Material for Neural Stem Cell Growth. ACS Appl Mater Interfaces. 2016 Jan 13; 8(1):278-84. Phan L, Kautz R, Arulmoli J, Kim IH, Le DT, Shenk MA, Pathak MM, Flanagan LA, Tombola F, Gorodetsky AA. PMID: 26703760.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Sci Rep. 2015 Feb 17; 5:8499. Arulmoli J, Pathak MM, McDonnell LP, Nourse JL, Tombola F, Earthman JC, Flanagan LA. PMID: 25686615.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    11. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16148-53. Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, Bernardis E, Flanagan LA, Tombola F. PMID: 25349416.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCellsCTClinical Trials
    12. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014; 9(8):e105926. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. PMID: 25165868.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron. 2013 Jan 23; 77(2):274-87. Hong L, Pathak MM, Kim IH, Ta D, Tombola F. PMID: 23352164.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    14. Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40. Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. PMID: 17920020.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
    15. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 2007 Feb 01; 445(7127):546-9. Tombola F, Pathak MM, Gorostiza P, Isacoff EY. PMID: 17187057.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    16. How does voltage open an ion channel? Annu Rev Cell Dev Biol. 2006; 22:23-52. Tombola F, Pathak MM, Isacoff EY. PMID: 16704338.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    17. How far will you go to sense voltage? Neuron. 2005 Dec 08; 48(5):719-25. Tombola F, Pathak MM, Isacoff EY. PMID: 16337910.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    18. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 2005 Feb 03; 45(3):379-88. Tombola F, Pathak MM, Isacoff EY. PMID: 15694325.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    19. The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol. 2005 Jan; 125(1):57-69. Pathak M, Kurtz L, Tombola F, Isacoff E. PMID: 15623895.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
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