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Elizabeth Head

Photo of Elizabeth Head
Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1225
ORCID ORCID Icon1115-6396 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Toronto, Toronto CanadaBSc08/1991Neuroscience
    University of Toronto, Toronto CanadaMA08/1992Psychology
    University of Toronto, Toronto CanadaPhD01/1997Neuroscience

    Collapse Overview 
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    Collapse Research 
    Collapse research activities and funding
    Training in Translational ADRD Neuroscience (TITAN)
    NIH T32AG073088Sep 1, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
    NIH U19AG068054Sep 30, 2020 - Aug 31, 2025
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down syndrome (ABC-DS)
    NIA U19AG068054Jul 1, 2020 - Jun 30, 2025
    Role: MPI
    Description: Alzheimer’s disease (AD) is a major public health crisis for our aging population. People with Down Syndrome(DS) are at high risk for AD and because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD. Reliable biomarkers of preclinical AD will enable new options for intervention and promote health for people with DS and in the general population.
    University of California Alzheimer's Disease Center
    NIA P30AG066519Apr 1, 2020 - Mar 31, 2025
    Role: Core Lead REC, Co-Investigator - Neuropathology Core and Down syndrome cohort core
    Description: The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving Alzheimer’s disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.
    Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
    NIH R01AG056998Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Description: Preclinical evaluation of tacrolimus in a canine model of Alzheimer’s disease This proposal uses a longitudinal design in to evaluate the safety and efficacy of the calcineurin inhibitor, tacrolimus, in an aging canine model of Alzheimer’s disease
    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cross-Sectional FDG in Down Syndrome and Autosomal Dominant Alzheimer's Disease. Ann Neurol. 2025 Sep 22. Abdelmoity O, Wisch JK, Kennedy JT, Goyal M, Vlassenko A, Flores S, Handen BL, Head E, Keator D, Rafii MS, Lao P, Lai F, Rosas HD, Hartley SL, Zaman S, Brickman AM, Tudorascu D, Lee JH, Allegri RF, Keefe S, la Fougere C, Llibre-Guerra J, Ikeuchi T, Morris JC, Roh JH, Day GS, Levin J, Schofield PR, Gordon BA, Benzinger TLS, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome and the Dominantly Inherited Alzheimer Network. PMID: 40977577.
      View in: PubMed   Mentions:    Fields:    
    2. Impaired parasympathetic network function confers susceptibility to neurodegeneration and memory impairment in older adults with elevated beat-to-beat blood pressure variability. J Alzheimers Dis. 2025 Nov; 108(1):411-420. Lohman T, Sible I, Kapoor A, Engstrom AC, Shenasa F, Alitin JPM, Gaubert A, Rodgers KE, Bradford D, Mather M, Han SD, Head E, Sordo L, Thayer JF, Nation DA. PMID: 40953110.
      View in: PubMed   Mentions:    Fields:    
    3. Down syndrome and Alzheimer's disease: insights into biomarkers, clinical symptoms, and pathology. Lancet Neurol. 2025 Sep; 24(9):753-762. Rafii MS, Schlachetzki Z, Barroeta I, Head E, Fortea J, Ances BM. PMID: 40818475.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome. Alzheimers Dement. 2025 Sep; 21(9):e70679. Lao P, Edwards N, Flores-Aguilar L, Alshikho MJ, Smith A, LeMay R, Hahm J, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian B, Mapstone M, Handen B, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators, Gutierrez J, Wilcock D, Head E, Brickman AM. PMID: 40951960; PMCID: PMC12434704.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Alzheimer's Disease Research Center Down Syndrome Cores: Experience from two sites. Alzheimers Dement. 2025 Aug; 21(8):e70612. Ptomey L, Hom C, Wilkins H, Doran E, Wright ST, Hoang D, Delehoy B, Lott IT, Perales-Puchalt J, Helsel B, Burns J, Grill JD, Head E. PMID: 40847661; PMCID: PMC12374163.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome. Alzheimers Dement. 2025 Aug; 21(8):e70572. LeMerise LG, Guerrero-Gonzalez J, McVea A, Zammit M, Kecskemeti S, Hartley S, Head E, Mapstone M, Handen B, Alexander A, Christian B, ABC-DS Investigators. PMID: 40779433; PMCID: PMC12333877.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. U1-70K and U1A and tau pathogenesis in demented and non-demented individuals with Down syndrome. Alzheimers Dement. 2025 Aug; 21(8):e70474. Perez SE, Miguel JC, Nadeem M, Malek-Ahmadi M, Hales CM, Head E, Mufson EJ. PMID: 40762109; PMCID: PMC12322699.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Late-life emergence of neuropsychiatric symptoms and risk of cognitive impairment in cognitively unimpaired individuals. Alzheimers Dement. 2025 Aug; 21(8):e70619. Kim TH, Head E, Stark CEL, Sordo L, Kirby KA, Corona MG, McDonnell M, Grill JD, Sultzer DL. PMID: 40851415; PMCID: PMC12375875.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease. Genome Biol. 2025 Jul 17; 26(1):210. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, da Fonseca EL, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma AB, Abner E, Adams LD, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Auerbach S, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Friedland RP, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Go RCP, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kikuchi M, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, Obisesan T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Petrovitch H, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sabbagh M, Sadovnick AD, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, George-Hyslop PS, Starks TD, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsolaki M, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, et al. PMID: 40676597; PMCID: PMC12273372.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Common neuropathologic change drivers of hippocampal sclerosis of ageing. Brain. 2025 Jul 07; 148(7):2400-2411. Woodworth DC, Lou JJ, Yong WH, Head E, Corrada MM, Nelson PT, Sajjadi SA. PMID: 40323260; PMCID: PMC12233507.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Leptin levels are associated with body mass index and Alzheimer's disease in Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70448. Sordo L, Du A, Sandadi V, Dustagheer FB, Pascual J, Ngo P, Hom CL, Doran E, Head E. PMID: 40635163; PMCID: PMC12240871.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Gait variability as a marker of white matter integrity in individuals with Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70407. Leach EM, Powell DK, Glueck AC, Head E, Ibrahim MW, Anderson-Mooney AJ, Van Pelt KL, Harp JP, Schmitt FA, Bahrani AA. PMID: 40579790; PMCID: PMC12205008.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70358. Aslam MM, Dang LT, Shi R, Fan KH, Cheema AN, Xicota L, Minhas D, Luo W, Zafari N, Acharya V, Feingold E, Krinsky-McHale S, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS), Lee JH, Cruchaga C, Kamboh MI. PMID: 40667702; PMCID: PMC12265027.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70408. Andrews EJ, Ngo PT, Pascual JR, Gonzalez F, Phelan M, Wright ST, Harp J, Schmitt F, Lai F, Lao PJ, Brickman AM, Kofler J, Ikonomovic MD, Head E, ABC-DS Consortium. PMID: 40673442; PMCID: PMC12268376.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Cholinotrophic basal forebrain connectome dysfunction in Down syndrome with and without dementia. iScience. 2025 Aug 15; 28(8):113041. Moreno-Rodriguez M, Perez SE, Nadeem M, Head E, Mufson EJ. PMID: 40822354; PMCID: PMC12357115.
      View in: PubMed   Mentions:
    16. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. Lancet Neurol. 2025 Jul; 24(7):591-600. Janelidze S, Collij LE, Mattsson-Carlgren N, Antill A, Laymon CM, Lott I, Rosas HD, Minhas DS, Luo W, Zaman S, Alzheimer's Biomarker Consortium–Down Syndrome investigators, Mapstone M, Head E, Lai F, Hartley SL, Ances BM, Krinsky-McHale SJ, Lee JH, Ossenkoppele R, Christian BT, Handen BL, Hansson O. PMID: 40541209; PMCID: PMC12174012.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70398. Fan KH, Shi R, Cheema AN, Dang LT, Xicota L, Krinsky-McHale S, Aslam MM, Zafari N, Acharya V, Feingold E, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS), Cruchaga C, Lee JH, Kamboh MI. PMID: 40667715; PMCID: PMC12264832.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments. Alzheimers Dement. 2025 Jul; 21(7):e70424. Fu JF, Garimella A, Lapointe A, Aye WWT, Chen CD, Lee JH, Krinsky-McHale SJ, Zaman S, Lott IT, Hom C, Ances B, Head E, Mapstone M, Lai F, Handen BL, Laymon CM, Hartley SL, Christian BT, Rentz DM, Johnson KA, Rosas HD, Price JC, Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS). PMID: 40588723; PMCID: PMC12208798.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease. Alzheimers Dement (N Y). 2025 Jul-Sep; 11(3):e70127. Fleming VL, Peven J, Helsel BC, Ptomey LT, Clina J, Barry A, Ances BM, Handen BL, Christian BT, Laymon C, Zammit M, Head E, Mapstone M, Okonkwo O, Hartley SL, Alzheimer Biomarkers Consortium – Down Syndrome. PMID: 40584896; PMCID: PMC12204845.
      View in: PubMed   Mentions:
    20. The future of biomarkers for vascular contributions to cognitive impairment and dementia (VCID): proceedings of the 2025 annual workshop of the Albert research institute for white matter and cognition. Geroscience. 2025 Oct; 47(5):6177-6190. Lennon MJ, Karvelas N, Ganesh A, Whitehead S, Sorond FA, Durán Laforet V, Head E, Arfanakis K, Kolachalama VB, Liu X, Lu H, Ramirez J, Walker K, Weekman E, Wellington CL, Winston C, Barone FC, Corriveau RA. PMID: 40542975; PMCID: PMC12634942.
      View in: PubMed   Mentions:    Fields:    
    21. Applying machine learning to assist in the morphometric assessment of brain arteriolosclerosis through automation. Free Neuropathol. 2025; 6:12. Lou JJ, Chang P, Nava KD, Chantaduly C, Wang HP, Yong WH, Patel V, Chaudhari AJ, Vasquez R, Monuki E, Head E, Vinters HV, Magaki S, Harvey DJ, Chuah CN, DeCarli CS, Williams CK, Keiser M, Dugger BN. PMID: 40510864; PMCID: PMC12159543.
      View in: PubMed   Mentions:
    22. The history of Down syndrome-associated Alzheimer's disease; past, present, and future. Alzheimers Dement. 2025 Jun; 21(6):e70158. Maure-Blesa L, Carmona-Iragui M, Lott I, Head E, Wisniewski T, Rafii MS, Espinosa J, Flórez J, Mobley WC, Holland A, Strydom A, Zaman S, Fortea J. PMID: 40469048; PMCID: PMC12138279.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimers Dement. 2025 Jun; 21(6):e70322. Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O'Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. PMID: 40536124; PMCID: PMC12177674.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 Jun; 21(6):e70387. Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL, Alzheimer's Biomarkers Consortium–Down Syndrome. PMID: 40545561; PMCID: PMC12183108.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations. Alzheimers Dement. 2025 Jun; 21(6):e70357. McVea A, DiFilippo A, McLachlan M, Betcher B, Zammit M, Betthauser TJ, Converse A, Murali D, Stone C, Hartley S, Johnson S, Tudorascu DL, Laymon CM, Cohen AD, Minhas D, Luo W, Mathis C, Lao PJ, Ances B, Zaman S, Mapstone M, Head E, Handen BL, Christian BT, ABC-DS investigators. PMID: 40556306; PMCID: PMC12187968.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a Down syndrome in vitro model. Acta Neuropathol. 2025 05 30; 149(1):54. Lioudyno MI, Sevrioukov EA, Olivarria GM, Hitchcock L, Javonillo DI, Campos SM, Rivera I, Wright ST, Head E, Fortea J, Wisniewski T, Cuello AC, Do Carmo S, Lane TE, Busciglio J. PMID: 40445428; PMCID: PMC12125050.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease. Acta Neuropathol. 2025 05 19; 149(1):49. Farrell C, Buhidma Y, Mumford P, Heywood WE, Hällqvist J, Flores-Aguilar L, Andrews EJ, Rahimzadah N, Taso OS, Doran E, Swarup V, Head E, Lashley T, Mills K, Toomey CE, Wiseman FK. PMID: 40387921; PMCID: PMC12089208.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI. J Neuropathol Exp Neurol. 2025 May 01; 84(5):364-378. Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein HJ, Mettenburg JM, Yong WH, Head E, Ikonomovic MD, Ibrahim TS, Kofler JK, Alzheimer Biomarker Consortium—Down Syndrome . PMID: 40063697; PMCID: PMC12012357.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 May; 21(5):e70294. Handen BL, Mapstone M, Hartley S, Andrews H, Christian B, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O'Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 40371686; PMCID: PMC12079517.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome. J Intellect Disabil Res. 2025 Jul; 69(7):569-581. Schworer EK, Handen BL, Krinsky-McHale S, Hom CL, Clare ICH, Harp JP, Pulsifer MB, Mapstone M, Head E, Christian BT, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 40254895; PMCID: PMC12199718.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11; 17(1):19. Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40217501; PMCID: PMC11987311.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement. 2025 Apr; 21(4):e70211. Barry A, Peven JC, Handen BL, Bolt D, Krinsky-McHale SJ, Hom CL, Clare ICH, Glueck A, Harp J, Schmitt F, Zammit M, Minhas D, Luo W, Laymon C, Price J, Lee JH, Lott I, Cohen A, Ances BM, Pulsifer M, Rosa HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40289844; PMCID: PMC12035545.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    33. Resistance and resilience to Alzheimer's disease in Down syndrome. Alzheimers Dement. 2025 04; 21(4):e70151. Boyle R, Koops EA, Ances B, Andrews EJ, Arenaza-Urquijo EM, Bejanin A, Brickman AM, Buckley RF, Clas GS, Costello E, Coughlan GT, Conley AC, Deng F, de Paula Faria D, Edwards N, Flores-Aguilar L, Fortea J, Ghazi Saidi L, Head E, Hom CL, Koenig K, Lao P, Lengyel I, Li YJ, Loi S, Loughrey D, McGlinchey E, Newhouse P, Pertierra L, Prokopiou PC, Qi Q, de Paula França Resende E, Russell J, Scanlon CE, Schneider C, Schultz SA, Seto M, Shaka S, Soldan A, Vaqué Alcázar L, Weng Y, Wilson JE, Zaman SH, Zsadányi SE, Hartley S. PMID: 40289889; PMCID: PMC12035553.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers. Alzheimers Dement. 2025 Apr; 21(4):e70141. McLachlan M, Bettcher B, McVea A, DiFilippo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Rosas HD, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT, Investigators AD. PMID: 40189783; PMCID: PMC11972983.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Daily mindfulness practice with and without slow breathing has opposing effects on plasma amyloid beta levels. medRxiv. 2025 Mar 11. Nashiro K, Cahn BR, Choi P, Lee HRJ, Satchi S, Min J, Yoo HJ, Cho C, Mercer N, Sordo L, Head E, Choupan J, Mather M. PMID: 40162262; PMCID: PMC11952629.
      View in: PubMed   Mentions:
    36. Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome. Alzheimers Dement. 2025 Mar; 21(3):e70034. Dohl J, Treadwell Z, Norris C, Head E. PMID: 40042516; PMCID: PMC11881635.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease. bioRxiv. 2025 Feb 25. Farrell C, Buhidma Y, Mumford P, Heywood WE, Hällqvist J, Flores-Aguilar L, Andrews E, Rahimzadah N, Taso OS, Doran E, Swarup V, Head E, Lashley T, Mills K, Toomey CE, Wiseman FK. PMID: 40060680; PMCID: PMC11888362.
      View in: PubMed   Mentions:
    38. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. bioRxiv. 2025 Feb 06. Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O'Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. PMID: 39975068; PMCID: PMC11839036.
      View in: PubMed   Mentions:
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    40. Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome. Alzheimers Dement. 2025 Feb; 21(2):e14519. Kennedy JT, Wisch JK, Dincer A, Roman J, Gordon BA, Handen B, Benzinger TLS, Head E, Mapstone M, Christian BT, Tudorascu DL, Laymon CL, Hartley SL, Lao P, Brickman AM, Zaman SH, Ances BM, ABC-DS and DIAN Consortia. PMID: 39807622; PMCID: PMC11848172.
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    42. Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer's disease in two independent study cohorts. Mol Psychiatry. 2025 Jun; 30(6):2573-2583. Bigio B, Lima-Filho RAS, Barnhill O, Sudo FK, Drummond C, Assunção N, Vanderborght B, Beasley J, Young S, Korman A, Jones DR, Sultzer DL, Ferreira ST, Mattos P, Head E, Tovar-Moll F, De Felice FG, Lourenco MV, Nasca C. PMID: 39774493.
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    43. Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society. Neuromolecular Med. 2025 01 05; 27(1):5. Flores-Aguilar L, Hamlett ED, Araya P, Barone E, Bhattacharyya A, Carmona-Iragui M, Chan L, Christian B, Costa ACS, Costanzo F, Del Hoyo Soriano L, Dierssen M, Eichler EE, Fisher E, Galbraith M, Ghosh S, Gimenez S, Guedj F, Guidi S, Iulita MF, Mobley W, Pelleri MC, Potier MC, Rabin KR, Rachubinski A, Rebillat AS, Rubenstein E, Saternos H, Sordo L, Strydom A, Valle-Tamayo N, Waugh KA, Yu E, Zeldich E, Busciglio J, Head E. PMID: 39756004; PMCID: PMC11700910.
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    44. Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. Alzheimers Dement. 2025 Jan; 21(1):e14541. Thorwald MA, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O'Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. PMID: 39876821; PMCID: PMC11775463.
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    45. Neuropathology of trisomy 21 mosaicism in a case with early-onset dementia. Alzheimers Dement. 2025 Jan; 21(1):e14394. Ngo PT, Pascual JR, Wright S, Williams CK, Magaki S, Yong WH, Vinters HV, Ringman JM, Head E. PMID: 39655579; PMCID: PMC11772706.
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    46. The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers. medRxiv. 2024 Dec 06. McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT. PMID: 39677434; PMCID: PMC11643166.
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    48. Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults. Neurobiol Aging. 2025 03; 147:12-21. Dutt S, Bachman SL, Dahl MJ, Li Y, Yew B, Jang JY, Ho JK, Nashiro K, Min J, Yoo HJ, Gaubert A, Nguyen A, Blanken AE, Sible IJ, Marshall AJ, Kapoor A, Alitin JPM, Hoang K, Rouanet J, Sordo L, Head E, Shao X, Wang DJJ, Mather M, Nation DA. PMID: 39637519; PMCID: PMC11781958.
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    49. Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease. Nat Genet. 2024 Dec; 56(12):2704-2717. Miyoshi E, Morabito S, Henningfield CM, Das S, Rahimzadeh N, Shabestari SK, Michael N, Emerson N, Reese F, Shi Z, Cao Z, Srinivasan SS, Scarfone VM, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC–DS), Head E, Green KN, Swarup V. PMID: 39578645; PMCID: PMC11631771.
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    50. Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. Alzheimers Dement. 2025 Jan; 21(1):e14396. Engstrom AC, Alitin JPM, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJJ, Nation DA. PMID: 39555916; PMCID: PMC11772704.
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    51. The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome. Alzheimers Dement. 2025 Jan; 21(1):e14359. Boerwinkle AH, Wisch JK, Handen BL, Head E, Mapstone M, Rafii MS, O'Bryant SE, Krinsky-McHale SJ, Lai F, Rosas HD, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome. PMID: 39535359; PMCID: PMC11782213.
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    52. Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring. Alzheimers Dement. 2025 Jan; 21(1):e14364. Petersen ME, Flores-Aguilar L, Head E, Montoliu-Gaya L, Strydom A, Pape SE, Fortea J, Ashton NJ, Udeh-Momoh C, O'Bryant SE, German D, Despa F, Mapstone M, Zetterberg H. PMID: 39535517; PMCID: PMC11782192.
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    53. Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease. Neurobiol Aging. 2025 02; 146:1-14. Sordo L, Ubele MF, Boaz KA, Mefford JL, Jones ED, McCarty KL, van Rooyen HY, Smiley J, Bembenek Bailey SA, Perpich JA, Meacham B, Powell DK, Bresch F, Crump JW, Phelan MJ, Noche JA, Stark CE, Puskás LG, Norris CM, Head E. PMID: 39547056.
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    54. The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome. EBioMedicine. 2024 Dec; 110:105433. Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 39500037; PMCID: PMC11570228.
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    55. Transcript errors generate amyloid-like proteins in huwman cells. Nat Commun. 2024 10 07; 15(1):8676. Chung CS, Kou Y, Shemtov SJ, Verheijen BM, Flores I, Love K, Del Dosso A, Thorwald MA, Liu Y, Hicks D, Sun Y, Toney RG, Carrillo L, Nguyen MM, Biao H, Jin Y, Jauregui AM, Quiroz JD, Head E, Moore DL, Simpson S, Thomas KW, Coba MP, Li Z, Benayoun BA, Rosenthal JJC, Kennedy SR, Quadrato G, Gout JF, Chen L, Vermulst M. PMID: 39375347; PMCID: PMC11458900.
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    56. Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome. JAMA Neurol. 2024 Oct 01; 81(10):1066-1072. Liu L, Saba A, Pascual JR, Miller MB, Hennessey EL, Lott IT, Brickman AM, Wilcock DM, Harp JP, Schmitt FA, Selkoe DJ, Chhatwal JP, Head E. PMID: 39158850; PMCID: PMC11334015.
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    57. Evaluating the updated LATE-NC staging criteria using data from NACC. Alzheimers Dement. 2024 Dec; 20(12):8359-8373. Woodworth DC, Nguyen KM, Sordo L, Scambray KA, Head E, Kawas CH, Corrada MM, Nelson PT, Sajjadi SA. PMID: 39352226; PMCID: PMC11667507.
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    59. Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease. bioRxiv. 2024 Sep 08. Shi Z, Das S, Morabito S, Miyoshi E, Stocksdale J, Emerson N, Srinivasan SS, Shahin A, Rahimzadeh N, Cao Z, Silva J, Castaneda AA, Head E, Thompson L, Swarup V. PMID: 39282421; PMCID: PMC11398495.
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    62. Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. medRxiv. 2024 Jun 19. Engstrom AC, Alitin JP, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJ, Nation DA. PMID: 38946941; PMCID: PMC11213117.
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    64. Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice. bioRxiv. 2024 Jun 13. Thorwald M, Godoy-Lugo JA, Garcia G, Silva J, Kim M, Christensen A, Mack WJ, Head E, O'Day PA, Benayoun BA, Morgan TE, Pike CJ, Higuchi-Sanabria R, Forman HJ, Finch CE. PMID: 37034750; PMCID: PMC10081222.
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    66. A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv. 2024 Jun 03. Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 38883742; PMCID: PMC11177914.
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    69. Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. medRxiv. 2024 May 15. Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein H, Mettenburg JM, Yong W, Head E, Ikonomovic M, Ibrahim T, Kofler J, Alzheimer’s Biomarker Consortium on Down syndrome study. PMID: 38798514; PMCID: PMC11118630.
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    71. A pathway linking pulse pressure to dementia in adults with Down syndrome. Brain Commun. 2024; 6(3):fcae157. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards NC, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 38764776; PMCID: PMC11099660.
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    77. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12542. DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O'Bryant S, Yassa MA. PMID: 38348178; PMCID: PMC10859879.
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    79. Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome. J Alzheimers Dis. 2024; 101(2):541-561. Saternos H, Hamlett ED, Guzman S, Head E, Granholm AC, Ledreux A. PMID: 39213062; PMCID: PMC12101226.
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    80. Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue. ACS Cent Sci. 2024 Jan 24; 10(1):104-121. Kreutzer AG, Parrocha CMT, Haerianardakani S, Guaglianone G, Nguyen JT, Diab MN, Yong W, Perez-Rosendahl M, Head E, Nowick JS. PMID: 38292607; PMCID: PMC10823522.
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    84. Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease. bioRxiv. 2023 Jul 26. Miyoshi E, Morabito S, Henningfield CM, Rahimzadeh N, Kiani Shabestari S, Das S, Michael N, Reese F, Shi Z, Cao Z, Scarfone V, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Head E, Green KN, Swarup V. PMID: 37546983; PMCID: PMC10402031.
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    86. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, et al. PMID: 37461624; PMCID: PMC10350126.
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    88. Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia. Neurobiol Aging. 2023 08; 128:43-48. Kapoor A, Gaubert A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Nguyen A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shenasa F, Rodgers KE, Martini AC, Head E, Nation DA. PMID: 37156179; PMCID: PMC10852216.
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    89. Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12419. Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. PMID: 37035460; PMCID: PMC10075195.
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    90. Increased plasma DYRK1A with aging may protect against neurodegenerative diseases. Transl Psychiatry. 2023 04 04; 13(1):111. Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. PMID: 37015911; PMCID: PMC10073199.
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    91. Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts. medRxiv. 2023 Mar 10. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) investigators. PMID: 36945447; PMCID: PMC10029060.
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    93. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2023 01; 22(1):55-65. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome, Dominantly Inherited Alzheimer Network. PMID: 36517172; PMCID: PMC9979840.
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    94. Weight Loss and Alzheimer's Disease in Down Syndrome. J Alzheimers Dis. 2023; 91(3):1215-1227. Fleming V, Helsel BC, Ptomey LT, Rosas HD, Handen B, Laymon C, Christian BT, Head E, Mapstone M, Lai F, Krinsky-McHale S, Zaman S, Ances BM, Lee JH, Hartley SL, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) Consortium. PMID: 36565120; PMCID: PMC9940268.
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    95. Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome. J Alzheimers Dis. 2023; 95(1):213-225. Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 37482997; PMCID: PMC10578224.
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    96. Amyloid futures in the expanding pathology of brain aging and dementia. Alzheimers Dement. 2023 06; 19(6):2605-2617. Thorwald MA, Silva J, Head E, Finch CE. PMID: 36536382; PMCID: PMC10271937.
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    97. Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116. Chen XQ, Zuo X, Becker A, Head E, Mobley WC. PMID: 36370135; PMCID: PMC10175517.
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    98. Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society. Mol Syndromol. 2023 Apr; 14(2):89-100. Hamlett ED, Flores-Aguilar L, Handen B, Potier MC, Granholm AC, Sherman S, Puig V, Santoro JD, Carmona-Iragui M, Rebillat AS, Head E, Strydom A, Busciglio J. PMID: 37064334; PMCID: PMC10090974.
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    100. Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults. Sci Rep. 2022 10 13; 12(1):17197. Sible IJ, Yew B, Jang JY, Alitin JPM, Li Y, Gaubert A, Nguyen A, Dutt S, Blanken AE, Ho JK, Marshall AJ, Kapoor A, Shenasa F, Rodgers KE, Sturm VE, Head E, Martini A, Nation DA. PMID: 36229634; PMCID: PMC9561652.
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    101. Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome. Front Neurosci. 2022; 16:954999. Andrews EJ, Martini AC, Head E. PMID: 36033603; PMCID: PMC9411995.
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    103. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022 06 23; 185(13):2213-2233.e25. Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. PMID: 35750033; PMCID: PMC9340815.
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    104. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Rep. 2022 06 14; 39(11):110961. Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M. PMID: 35705056; PMCID: PMC9285116.
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    105. Commentary on Oeckl et al., "Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181". Ann Neurol. 2022 07; 92(1):3-5. Head E, Zetterberg H. PMID: 35599543; PMCID: PMC9348592.
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    106. Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12324. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB, Alzheimer's Biomarkers Consortium. PMID: 35634535; PMCID: PMC9131930.
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    108. Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum. Sleep Adv. 2022; 3(1):zpac013. Lao P, Zimmerman ME, Hartley SL, Gutierrez J, Keator D, Igwe KC, Laing KK, Cotton-Samuel D, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Diana Rosas H, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 35669316; PMCID: PMC9154738.
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    110. Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group. J Neurodev Disord. 2022 03 23; 14(1):22. Baumer NT, Becker ML, Capone GT, Egan K, Fortea J, Handen BL, Head E, Hendrix JE, Litovsky RY, Strydom A, Tapia IE, Rafii MS. PMID: 35321660; PMCID: PMC8942061.
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    111. Probing the proteome to explore potential correlates of increased Alzheimer's-related cerebrovascular disease in adults with Down syndrome. Alzheimers Dement. 2022 10; 18(10):1744-1753. Moni F, Petersen ME, Zhang F, Lao PJ, Zimmerman ME, Gu Y, Gutierrez J, Rizvi B, Laing KK, Igwe KC, Sathishkumar M, Keator D, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, O'Bryant S, Brickman AM. PMID: 35212182; PMCID: PMC9399305.
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    112. Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Disabil Health J. 2022 07; 15(3):101278. Hartley SL, Fleming V, Piro-Gambetti B, Cohen A, Ances BM, Yassa MA, Brickman AM, Handen BL, Head E, Mapstone M, Christian BT, Lott IT, Doran E, Zaman S, Krinsky-McHale S, Schmitt FA, Hom C, Schupf N, ABC-DS Group. PMID: 35256308; PMCID: PMC8849846.
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    113. Primitive Reflexes and Dementia in Adults With Down Syndrome. Neurol Clin Pract. 2022 Feb; 12(1):6-13. Harp J, Koehl L, Van Pelt K, Head E, Jicha G, Robertson W, Lightner D, Lott I, Schmitt F. PMID: 36157622; PMCID: PMC9491499.
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    114. Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer's Disease in People with Down Syndrome. J Alzheimers Dis. 2022; 85(1):153-165. DiProspero ND, Keator DB, Phelan M, van Erp TGM, Doran E, Powell DK, Van Pelt KL, Schmitt FA, Head E, Lott IT, Yassa MA. PMID: 34776436; PMCID: PMC9017677.
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    115. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022 06; 18(6):1203-1234. Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. PMID: 34757693; PMCID: PMC9085977.
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    116. Alzheimer's disease associated with Down syndrome: a genetic form of dementia. Lancet Neurol. 2021 11; 20(11):930-942. Fortea J, Zaman SH, Hartley S, Rafii MS, Head E, Carmona-Iragui M. PMID: 34687637; PMCID: PMC9387748.
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    117. Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Brain Sci. 2021 Aug 25; 11(9). Harp JP, Koehl LM, Pelt KLV, Hom CL, Doran E, Head E, Lott IT, Schmitt FA. PMID: 34573150; PMCID: PMC8468129.
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    118. Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer's Disease. Front Aging Neurosci. 2021; 13:728739. Pivtoraiko VN, Racic T, Abrahamson EE, Villemagne VL, Handen BL, Lott IT, Head E, Ikonomovic MD. PMID: 34489686; PMCID: PMC8416541.
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    119. Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study. Lancet Neurol. 2021 08; 20(8):605-614. Carmona-Iragui M, Alcolea D, Barroeta I, Videla L, Muñoz L, Van Pelt KL, Schmitt FA, Lightner DD, Koehl LM, Jicha G, Sacco S, Mircher C, Pape SE, Hithersay R, Clare ICH, Holland AJ, Nübling G, Levin J, Zaman SH, Strydom A, Rebillat AS, Head E, Blesa R, Lleó A, Fortea J. PMID: 34302785; PMCID: PMC8852333.
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    120. APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. JAMA Neurol. 2021 08 01; 78(8):913-915. Lemere CA, Head E, Holtzman DM. PMID: 34228117.
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    121. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease. Nat Genet. 2021 08; 53(8):1143-1155. Morabito S, Miyoshi E, Michael N, Shahin S, Martini AC, Head E, Silva J, Leavy K, Perez-Rosendahl M, Swarup V. PMID: 34239132; PMCID: PMC8766217.
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    122. Neuropathology of Aging in Cats and its Similarities to Human Alzheimer's Disease. Front Aging. 2021; 2:684607. Sordo L, Martini AC, Houston EF, Head E, Gunn-Moore D. PMID: 35822024; PMCID: PMC9261448.
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    123. Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain. J Neurosci. 2021 06 09; 41(23):5124-5133. Radhakrishnan H, Ubele MF, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E. PMID: 33952632; PMCID: PMC8197636.
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    124. Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease. Alzheimers Dement (Amst). 2021; 13(1):e12184. Aschenbrenner AJ, Baksh RA, Benejam B, Beresford-Webb JA, Coppus A, Fortea J, Handen BL, Hartley S, Head E, Jaeger J, Levin J, Loosli SV, Rebillat AS, Sacco S, Schmitt FA, Thurlow KE, Zaman S, Hassenstab J, Strydom A. PMID: 33969175; PMCID: PMC8088591.
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    127. Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. J Alzheimers Dis. 2021; 79(2):671-681. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O'Bryant S, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS). PMID: 33337378; PMCID: PMC8273927.
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    128. Longitudinal assessment of dementia measures in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12075. Koehl L, Harp J, Van Pelt KL, Head E, Schmitt FA. PMID: 33225040; PMCID: PMC7666427.
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    158. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017; 7(14):3573-3584. O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. PMID: 28912896; PMCID: PMC5596444.
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    159. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med. 2018 01; 114:94-101. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. PMID: 28807816; PMCID: PMC5748251.
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    167. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016 10 04; 54(3):1251. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL. PMID: 27716679.
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    172. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain Cogn. 2016 Apr; 104:48-57. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. PMID: 26930369; PMCID: PMC4801771.
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    173. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis. 2016; 52(1):359-371. Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M. PMID: 26967221; PMCID: PMC4968087.
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    175. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. Head E, Lott IT, Wilcock DM, Lemere CA. PMID: 26651341; PMCID: PMC4948181.
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    178. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiol Aging. 2015 Sep; 36(9):2468-74. Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. PMID: 26103884; PMCID: PMC4602365.
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    179. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812; PMCID: PMC4324097.
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    180. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. J Alzheimers Dis. 2015; 44(4):1107-20. Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. PMID: 25391381; PMCID: PMC4677575.
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    181. Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? J Parkinsons Dis Alzheimers Dis. 2014 Dec 08; 1(1). Rohn TT, McCarty KL, Love JE, Head E. PMID: 25594074; PMCID: PMC4291017.
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    182. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PLoS One. 2014; 9(11):e111899. Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H, Spires-Jones TL, Catalano SM. PMID: 25390692; PMCID: PMC4229119.
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    183. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842; PMCID: PMC4314944.
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    184. Aging in the canine and feline brain. Vet Clin North Am Small Anim Pract. 2014 Nov; 44(6):1113-29. Vite CH, Head E. PMID: 25441628; PMCID: PMC4254595.
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    185. Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. Biochem J. 2014 Oct 15; 463(2):177-89. Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M. PMID: 25242166; PMCID: PMC4686233.
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    186. Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome? Alzheimers Res Ther. 2014; 6(5-8):61. Head E, Schmitt FA. PMID: 25478026; PMCID: PMC4255531.
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    187. An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radic Biol Med. 2014 Nov; 76:89-95. Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. PMID: 25151119; PMCID: PMC4252833.
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    188. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab. 2014 Oct; 34(10):1637-45. Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. PMID: 25052558; PMCID: PMC4269722.
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    189. Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta. 2014 Jul; 1842(7):1144-53. Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. PMID: 24735980; PMCID: PMC4062876.
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    190. Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med. 2014 Jun; 71:270-280. Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. PMID: 24675226; PMCID: PMC4686229.
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    191. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol. 2014; 5:47. Davis PR, Head E. PMID: 24711794; PMCID: PMC3968758.
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    192. Frontal white matter integrity in adults with Down syndrome with and without dementia. Neurobiol Aging. 2014 Jul; 35(7):1562-9. Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E. PMID: 24582640; PMCID: PMC3992921.
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    193. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. J Alzheimers Dis. 2014; 42(3):767-75. Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. PMID: 24927707; PMCID: PMC4392817.
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    194. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis. 2014; 42(4):1221-7. Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. PMID: 25024306; PMCID: PMC4198456.
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    195. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014; 39(1):191-210. Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. PMID: 24150111; PMCID: PMC4376359.
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    196. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta. 2013 Aug; 1832(8):1249-59. Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. PMID: 23603808; PMCID: PMC3940071.
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    197. A canine model of human aging and Alzheimer's disease. Biochim Biophys Acta. 2013 Sep; 1832(9):1384-9. Head E. PMID: 23528711; PMCID: PMC3937962.
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    198. Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS One. 2013; 8(3):e59735. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. PMID: 23555764; PMCID: PMC3605408.
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    199. Alzheimer's Disease in Down Syndrome. Eur J Neurodegener Dis. 2012 Dec; 1(3):353-364. Head E, Powell D, Gold BT, Schmitt FA. PMID: 25285303; PMCID: PMC4184282.
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    200. Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. J Cereb Blood Flow Metab. 2013 Feb; 33(2):205-14. Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. PMID: 23149553; PMCID: PMC3564189.
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    201. Aging and down syndrome. Curr Gerontol Geriatr Res. 2012; 2012:412536. Head E, Silverman W, Patterson D, Lott IT. PMID: 22844278; PMCID: PMC3400297.
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    203. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Curr Gerontol Geriatr Res. 2012; 2012:179318. Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. PMID: 22649448; PMCID: PMC3357506.
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    204. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012 Apr 10; 29(6):1054-70. Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. PMID: 22017610; PMCID: PMC3325552.
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    205. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. J Alzheimers Dis. 2012; 32(4):1029-42. Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. PMID: 22886019; PMCID: PMC4006672.
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    206. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol. 2011 Dec; 9(4):651-61. Martin SB, Dowling AL, Head E. PMID: 22654723; PMCID: PMC3263459.
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    207. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem. 2012 Jan; 120(1):135-46. Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. PMID: 22004509.
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    208. BACE2 expression increases in human neurodegenerative disease. Am J Pathol. 2012 Jan; 180(1):337-50. Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. PMID: 22074738; PMCID: PMC3338345.
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    209. Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. BJU Int. 2012 Jun; 109(11):1666-73. Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N'Dow J, Grigor KM, Edinburgh Urological Cancer Group. PMID: 22044434.
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    210. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72. Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. PMID: 21876463; PMCID: PMC3339866.
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    211. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 22046234; PMCID: PMC3202527.
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    212. Antioxidants in the canine model of human aging. Biochim Biophys Acta. 2012 May; 1822(5):685-9. Dowling AL, Head E. PMID: 22005070; PMCID: PMC3291812.
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    213. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta. 2012 Feb; 1822(2):130-8. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. PMID: 22009041; PMCID: PMC3260028.
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    214. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol. 2012 Aug; 15(7):981-7. Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. PMID: 21767440.
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    215. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neurosci Lett. 2011 Aug 26; 501(2):92-5. Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. PMID: 21763754; PMCID: PMC3174091.
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    216. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A. 2011 Aug; 155A(8):1939-48. Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. PMID: 21739598; PMCID: PMC3410645.
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    217. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 21546126; PMCID: PMC3154439.
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    218. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. PMID: 21516511; PMCID: PMC3179861.
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    219. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. PMID: 21460841; PMCID: PMC3090745.
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    220. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. J Alzheimers Dis. 2011; 23(3):399-409. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. PMID: 21116050; PMCID: PMC3219221.
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    221. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res. 2011 Mar; 63(3):172-80. Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. PMID: 21193043; PMCID: PMC3034810.
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    295. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology. 2003 Dec 23; 61(12):1673-9. Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. PMID: 14694028.
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    296. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. Zhao M, Su J, Head E, Cotman CW. PMID: 14678756.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    297. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. Eur J Immunol. 2003 Dec; 33(12):3232-41. Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. PMID: 14635031; PMCID: PMC1524857.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCellsPHPublic Health
    298. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. PMID: 14570555.
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    299. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. Bi X, Head E, Cotman CW, Lynch G. PMID: 12900930.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    300. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. J Neuropathol Exp Neurol. 2003 Sep; 62(9):917-26. Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. PMID: 14533781.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    301. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. PMID: 12931965.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    302. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. PMID: 12702875.
      View in: PubMed   Mentions: 1579     Fields:    Translation:HumansAnimalsCells
    303. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. PMID: 12551965; PMCID: PMC196651.
      View in: PubMed   Mentions: 85     Fields:    Translation:Animals
    304. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. PMID: 12505426.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    305. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
      View in: PubMed   Mentions: 20     Fields:    
    306. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. PMID: 12480733.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    307. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. PMID: 12213643.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    308. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. PMID: 12392784.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    309. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002 Jul; 82(2):375-81. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. PMID: 12124438.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    310. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. PMID: 12049325.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    311. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. Su JH, Kesslak JP, Head E, Cotman CW. PMID: 12070657.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    312. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. PMID: 11854529; PMCID: PMC122369.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    313. Insights into Abeta and presenilin from a canine model of human brain aging. Neurobiol Dis. 2002 Feb; 9(1):1-10. Head E, Torp R. PMID: 11848680.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    314. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct; 8(5):792-806. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. PMID: 11592849.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    315. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001 Apr; 8(2):252-65. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. PMID: 11300721.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    316. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol. 2001 Jan; 158(1):189-98. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. PMID: 11141492; PMCID: PMC1850275.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    317. Down syndrome and Alzheimer's disease: a link between development and aging. Ment Retard Dev Disabil Res Rev. 2001; 7(3):172-8. Lott IT, Head E. PMID: 11553933.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    318. Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther. 2001; 2(3):247-60. Head E. PMID: 19746668.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    319. Canine cognition, aging and neuropathology. Introduction. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):671-3. Head E, Cotman CW, Milgram NW. PMID: 11191707.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    320. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):777-86. Head E, Thornton PL, Tong L, Cotman CW. PMID: 11191712.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    321. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Exp Neurol. 2000 May; 163(1):111-22. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. PMID: 10785449.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    322. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000 Jan-Feb; 21(1):89-96. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. PMID: 10794853.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    323. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol. 1999 Oct; 56(10):1233-9. Johnson JK, Head E, Kim R, Starr A, Cotman CW. PMID: 10520939.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansCells
    324. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Exp Neurol. 1999 Jun; 157(2):277-88. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. PMID: 10364440.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    325. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging. 1998 Sep-Oct; 19(5):479-85. Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. PMID: 9880050.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    326. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging. 1998 Sep-Oct; 19(5):415-25. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. PMID: 9880044.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    327. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 07; 774(1-2):35-43. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. PMID: 9452189.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    328. Open field activity and human interaction as a function of age and breed in dogs. Physiol Behav. 1997 Nov; 62(5):963-71. Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. PMID: 9333188.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    329. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. PMID: 8661247.
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    330. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. PMID: 8744407.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
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