Elizabeth Head

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1225
ORCID ORCID Icon1115-6396 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, Toronto CanadaBSc08/1991Neuroscience
    University of Toronto, Toronto CanadaMA08/1992Psychology
    University of Toronto, Toronto CanadaPhD01/1997Neuroscience

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Training in Translational ADRD Neuroscience (TITAN)
    NIH T32AG073088Sep 1, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
    NIH U19AG068054Sep 30, 2020 - Aug 31, 2025
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down syndrome (ABC-DS)
    NIA U19AG068054Jul 1, 2020 - Jun 30, 2025
    Role: MPI
    Description: Alzheimer’s disease (AD) is a major public health crisis for our aging population. People with Down Syndrome(DS) are at high risk for AD and because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD. Reliable biomarkers of preclinical AD will enable new options for intervention and promote health for people with DS and in the general population.
    University of California Alzheimer's Disease Center
    NIA P30AG066519Apr 1, 2020 - Mar 31, 2025
    Role: Core Lead REC, Co-Investigator - Neuropathology Core and Down syndrome cohort core
    Description: The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving Alzheimer’s disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.
    Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
    NIH R01AG056998Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Description: Preclinical evaluation of tacrolimus in a canine model of Alzheimer’s disease This proposal uses a longitudinal design in to evaluate the safety and efficacy of the calcineurin inhibitor, tacrolimus, in an aging canine model of Alzheimer’s disease
    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer's Coordinating Center database. Acta Neuropathol. 2024 06 19; 147(1):103. Woodworth DC, Nguyen KM, Sordo L, Scambray KA, Head E, Kawas CH, Corrada MM, Nelson PT, Sajjadi SA. PMID: 38896163; PMCID: PMC11186885.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. medRxiv. 2024 Jun 19. Engstrom AC, Alitin JP, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJ, Nation DA. PMID: 38946941; PMCID: PMC11213117.
      View in: PubMed   Mentions:
    3. Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults. Alzheimers Res Ther. 2024 Jun 08; 16(1):124. Lohman T, Kapoor A, Engstrom AC, Shenasa F, Alitin JPM, Gaubert A, Rodgers KE, Bradford D, Mather M, Han SD, Head E, Sordo L, Thayer JF, Nation DA. PMID: 38851772; PMCID: PMC11162037.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv. 2024 Jun 03. Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 38883742; PMCID: PMC11177914.
      View in: PubMed   Mentions:
    5. Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome. Sci Rep. 2024 05 29; 14(1):12334. Lao P, Edwards N, Flores-Aguilar L, Alshikho M, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian BT, Mapstone M, Handen B, Zimmerman ME, Gutierrez J, Wilcock D, Head E, Brickman AM. PMID: 38811657; PMCID: PMC11137035.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings. Acta Neuropathol. 2024 05 27; 147(1):92. Granholm AE, Englund E, Gilmore A, Head E, Yong WH, Perez SE, Guzman SJ, Hamlett ED, Mufson EJ. PMID: 38801558; PMCID: PMC11130011.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI. medRxiv. 2024 May 15. Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein H, Mettenburg JM, Yong W, Head E, Ikonomovic M, Ibrahim T, Kofler J, Alzheimer’s Biomarker Consortium on Down syndrome study. PMID: 38798514; PMCID: PMC11118630.
      View in: PubMed   Mentions:
    8. A pathway linking pulse pressure to dementia in adults with Down syndrome. Brain Commun. 2024; 6(3):fcae157. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards NC, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 38764776; PMCID: PMC11099660.
      View in: PubMed   Mentions:
    9. The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults. medRxiv. 2024 May 03. Lohman T, Shenasa F, Sible I, Kapoor A, Engstrom AC, Dutt S, Head E, Sordo L, M Alitin JP, Gaubert A, Nguyen A, Nation DA. PMID: 38746307; PMCID: PMC11092712.
      View in: PubMed   Mentions:
    10. Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2024 May; 23(5):500-510. Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM, Alzheimer's Biomarker Consortium-Down syndrome, Dominantly Inherited Alzheimer Network. PMID: 38631766; PMCID: PMC11209765.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12582. Schworer EK, Handen BL, Petersen M, O'Bryant S, Peven JC, Tudorascu DL, Lee L, Krinsky-McHale SJ, Hom CL, Clare ICH, Christian BT, Schupf N, Lee JH, Head E, Mapstone M, Lott I, Ances BM, Zaman S, Brickman AM, Lai F, Rosas HD, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 38623384; PMCID: PMC11016818.
      View in: PubMed   Mentions:
    12. Age-related brain atrophy and the positive effects of behavioral enrichment in middle-aged beagles. J Neurosci. 2024 Apr 01. Noche JA, Radhakrishnan H, Ubele MF, Boaz K, Mefford JL, Jones ED, Perpich JA, McCarty K, Meacham B, Smiley J, Bailey SAB, Puskás LG, Powell DK, Sordo L, Phelan MJ, Norris CM, Head E, Stark CEL. PMID: 38561226.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease. bioRxiv. 2024 Mar 14. Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Finkbeiner S, Head E, Liu Y, Jiang P. PMID: 38559257; PMCID: PMC10979994.
      View in: PubMed   Mentions:
    14. Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement. 2024 Apr; 20(4):2670-2679. Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long-Life Family Study (LLFS), Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS). PMID: 38380866; PMCID: PMC11032545.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12542. DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O'Bryant S, Yassa MA. PMID: 38348178; PMCID: PMC10859879.
      View in: PubMed   Mentions:
    16. Down Syndrome Biobank Consortium: A perspective. Alzheimers Dement. 2024 Mar; 20(3):2262-2272. Aldecoa I, Barroeta I, Carroll SL, Fortea J, Gilmore A, Ginsberg SD, Guzman SJ, Hamlett ED, Head E, Perez SE, Potter H, Molina-Porcel L, Raha-Chowdhury R, Wisniewski T, Yong WH, Zaman S, Ghosh S, Mufson EJ, Granholm AC. PMID: 38270275; PMCID: PMC10984425.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue. ACS Cent Sci. 2024 Jan 24; 10(1):104-121. Kreutzer AG, Parrocha CMT, Haerianardakani S, Guaglianone G, Nguyen JT, Diab MN, Yong W, Perez-Rosendahl M, Head E, Nowick JS. PMID: 38292607; PMCID: PMC10823522.
      View in: PubMed   Mentions:
    18. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv. 2023 Nov 30. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 38076904; PMCID: PMC10705616.
      View in: PubMed   Mentions:
    19. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv. 2023 Oct 26. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards N, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 37961444; PMCID: PMC10635215.
      View in: PubMed   Mentions:
    20. Alzheimer's disease ferroptotic associations with oxidative damage and neuronal loss. bioRxiv. 2023 Sep 19. Thorwald MA, Godoy-Lugo JA, Silva J, Head E, O'Day PA, Morgan TE, Forman HJ, Finch CE. PMID: 37034750; PMCID: PMC10081222.
      View in: PubMed   Mentions:
    21. Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial. Sci Data. 2023 07 29; 10(1):503. Yoo HJ, Nashiro K, Min J, Cho C, Mercer N, Bachman SL, Nasseri P, Dutt S, Porat S, Choi P, Zhang Y, Grigoryan V, Feng T, Thayer JF, Lehrer P, Chang C, Stanley JA, Head E, Rouanet J, Marmarelis VZ, Narayanan S, Wisnowski J, Nation DA, Mather M. PMID: 37516756; PMCID: PMC10387077.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease. bioRxiv. 2023 Jul 26. Miyoshi E, Morabito S, Henningfield CM, Rahimzadeh N, Kiani Shabestari S, Das S, Michael N, Reese F, Shi Z, Cao Z, Scarfone V, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Head E, Green KN, Swarup V. PMID: 37546983; PMCID: PMC10402031.
      View in: PubMed   Mentions: 1  
    23. Plasma NT1-tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimers Dement. 2023 Dec; 19(12):5755-5764. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) investigators. PMID: 37438872; PMCID: PMC10784408.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, et al. PMID: 37461624; PMCID: PMC10350126.
      View in: PubMed   Mentions:
    25. Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old. Acta Neuropathol. 2023 09; 146(3):415-432. Sordo L, Qian T, Bukhari SA, Nguyen KM, Woodworth DC, Head E, Kawas CH, Corrada MM, Montine TJ, Sajjadi SA. PMID: 37382680; PMCID: PMC10412485.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia. Neurobiol Aging. 2023 08; 128:43-48. Kapoor A, Gaubert A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Nguyen A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shenasa F, Rodgers KE, Martini AC, Head E, Nation DA. PMID: 37156179; PMCID: PMC10852216.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12419. Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. PMID: 37035460; PMCID: PMC10075195.
      View in: PubMed   Mentions: 2  
    28. Increased plasma DYRK1A with aging may protect against neurodegenerative diseases. Transl Psychiatry. 2023 04 04; 13(1):111. Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. PMID: 37015911; PMCID: PMC10073199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts. medRxiv. 2023 Mar 10. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) investigators. PMID: 36945447; PMCID: PMC10029060.
      View in: PubMed   Mentions:
    30. Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Sci Rep. 2023 03 09; 13(1):3967. Min J, Rouanet J, Martini AC, Nashiro K, Yoo HJ, Porat S, Cho C, Wan J, Cole SW, Head E, Nation DA, Thayer JF, Mather M. PMID: 36894565; PMCID: PMC9998394.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2023 01; 22(1):55-65. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome, Dominantly Inherited Alzheimer Network. PMID: 36517172; PMCID: PMC9979840.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Weight Loss and Alzheimer's Disease in Down Syndrome. J Alzheimers Dis. 2023; 91(3):1215-1227. Fleming V, Helsel BC, Ptomey LT, Rosas HD, Handen B, Laymon C, Christian BT, Head E, Mapstone M, Lai F, Krinsky-McHale S, Zaman S, Ances BM, Lee JH, Hartley SL, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) Consortium. PMID: 36565120; PMCID: PMC9940268.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome. J Alzheimers Dis. 2023; 95(1):213-225. Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 37482997; PMCID: PMC10578224.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Amyloid futures in the expanding pathology of brain aging and dementia. Alzheimers Dement. 2023 06; 19(6):2605-2617. Thorwald MA, Silva J, Head E, Finch CE. PMID: 36536382; PMCID: PMC10271937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116. Chen XQ, Zuo X, Becker A, Head E, Mobley WC. PMID: 36370135; PMCID: PMC10175517.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    36. Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society. Mol Syndromol. 2023 Apr; 14(2):89-100. Hamlett ED, Flores-Aguilar L, Handen B, Potier MC, Granholm AC, Sherman S, Puig V, Santoro JD, Carmona-Iragui M, Rebillat AS, Head E, Strydom A, Busciglio J. PMID: 37064334; PMCID: PMC10090974.
      View in: PubMed   Mentions:
    37. Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 2022 11 16; 119(46):e2212954119. Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. PMID: 36343257; PMCID: PMC9674250.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults. Sci Rep. 2022 10 13; 12(1):17197. Sible IJ, Yew B, Jang JY, Alitin JPM, Li Y, Gaubert A, Nguyen A, Dutt S, Blanken AE, Ho JK, Marshall AJ, Kapoor A, Shenasa F, Rodgers KE, Sturm VE, Head E, Martini A, Nation DA. PMID: 36229634; PMCID: PMC9561652.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome. Front Neurosci. 2022; 16:954999. Andrews EJ, Martini AC, Head E. PMID: 36033603; PMCID: PMC9411995.
      View in: PubMed   Mentions: 5  
    40. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 2022 07 07; 29(7):1135-1153.e8. Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P. PMID: 35803230; PMCID: PMC9345168.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    41. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022 06 23; 185(13):2213-2233.e25. Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. PMID: 35750033; PMCID: PMC9340815.
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    59. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease. Nat Genet. 2021 08; 53(8):1143-1155. Morabito S, Miyoshi E, Michael N, Shahin S, Martini AC, Head E, Silva J, Leavy K, Perez-Rosendahl M, Swarup V. PMID: 34239132; PMCID: PMC8766217.
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    60. Neuropathology of Aging in Cats and its Similarities to Human Alzheimer's Disease. Front Aging. 2021; 2:684607. Sordo L, Martini AC, Houston EF, Head E, Gunn-Moore D. PMID: 35822024; PMCID: PMC9261448.
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    61. Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain. J Neurosci. 2021 06 09; 41(23):5124-5133. Radhakrishnan H, Ubele MF, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E. PMID: 33952632; PMCID: PMC8197636.
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    76. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12028. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators. PMID: 32258359; PMCID: PMC7131985.
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    81. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease. Dev Neurobiol. 2019 07; 79(7):622-638. Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. PMID: 31419370.
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    83. Alzheimer's disease in aging Down syndrome. Dev Neurobiol. 2019 07; 79(7):611-612. Cohen AD, Head E, Lee JH. PMID: 31545018.
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    84. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol. 2019 03; 15(3):135-147. Lott IT, Head E. PMID: 30733618; PMCID: PMC8061428.
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    85. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. J Alzheimers Dis. 2019; 67(1):103-112. Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. PMID: 30452414; PMCID: PMC6424116.
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    86. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019 02; 15(2):292-312. Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association. PMID: 30555031; PMCID: PMC6368893.
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    87. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. PMID: 30800043; PMCID: PMC6381890.
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    92. Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. PMID: 29740941; PMCID: PMC8028592.
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    93. An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Front Aging Neurosci. 2018; 10:7. Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. PMID: 29441010; PMCID: PMC5797595.
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    95. Down syndrome, beta-amyloid and neuroimaging. Free Radic Biol Med. 2018 01; 114:102-109. Head E, Helman AM, Powell D, Schmitt FA. PMID: 28935420; PMCID: PMC5748259.
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    96. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017; 7(14):3573-3584. O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. PMID: 28912896; PMCID: PMC5596444.
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    97. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med. 2018 01; 114:94-101. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. PMID: 28807816; PMCID: PMC5748251.
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    99. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017 06; 54:163-169. LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. PMID: 28385551; PMCID: PMC5638297.
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    100. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. J Alzheimers Dis. 2017; 56(2):459-470. Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. PMID: 27983553; PMCID: PMC5662115.
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    101. HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. Free Radic Biol Med. 2017 10; 111:262-269. Barone E, Head E, Butterfield DA, Perluigi M. PMID: 27838436; PMCID: PMC5639937.
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    102. Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxid Redox Signal. 2017 03 01; 26(7):280-298. Tramutola A, Di Domenico F, Barone E, Arena A, Giorgi A, di Francesco L, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. PMID: 27627691; PMCID: PMC5327052.
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    103. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016 10 04; 54(3):1251. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL. PMID: 27716679.
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    104. Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages. Neurobiol Aging. 2017 01; 49:86-99. Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E. PMID: 27776266; PMCID: PMC5154836.
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    105. Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Aging Dis. 2016 May; 7(3):267-77. Day RJ, McCarty KL, Ockerse KE, Head E, Rohn TT. PMID: 27330841; PMCID: PMC4898923.
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    106. Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Mol Neurodegener. 2016 05 23; 11(1):42. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. PMID: 27216421; PMCID: PMC4877764.
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    108. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain Cogn. 2016 Apr; 104:48-57. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. PMID: 26930369; PMCID: PMC4801771.
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    109. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis. 2016; 52(1):359-371. Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M. PMID: 26967221; PMCID: PMC4968087.
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    110. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016; 52(2):731-45. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL, Annapragada A. PMID: 27031484; PMCID: PMC4931553.
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    111. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. Head E, Lott IT, Wilcock DM, Lemere CA. PMID: 26651341; PMCID: PMC4948181.
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    112. Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils. ACS Chem Neurosci. 2016 Feb 17; 7(2):171-6. Fosso MY, McCarty K, Head E, Garneau-Tsodikova S, LeVine H. PMID: 26682772.
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    113. Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome. Biochim Biophys Acta. 2016 05; 1862(5):909-14. Wilcock DM, Schmitt FA, Head E. PMID: 26593849; PMCID: PMC4821721.
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    114. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiol Aging. 2015 Sep; 36(9):2468-74. Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. PMID: 26103884; PMCID: PMC4602365.
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    115. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812; PMCID: PMC4324097.
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    116. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. J Alzheimers Dis. 2015; 44(4):1107-20. Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. PMID: 25391381; PMCID: PMC4677575.
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    117. Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? J Parkinsons Dis Alzheimers Dis. 2014 Dec 08; 1(1). Rohn TT, McCarty KL, Love JE, Head E. PMID: 25594074; PMCID: PMC4291017.
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    118. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PLoS One. 2014; 9(11):e111899. Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H, Spires-Jones TL, Catalano SM. PMID: 25390692; PMCID: PMC4229119.
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    119. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842; PMCID: PMC4314944.
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    120. Aging in the canine and feline brain. Vet Clin North Am Small Anim Pract. 2014 Nov; 44(6):1113-29. Vite CH, Head E. PMID: 25441628; PMCID: PMC4254595.
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    122. Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome? Alzheimers Res Ther. 2014; 6(5-8):61. Head E, Schmitt FA. PMID: 25478026; PMCID: PMC4255531.
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    124. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab. 2014 Oct; 34(10):1637-45. Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. PMID: 25052558; PMCID: PMC4269722.
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    125. Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta. 2014 Jul; 1842(7):1144-53. Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. PMID: 24735980; PMCID: PMC4062876.
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    126. Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med. 2014 Jun; 71:270-280. Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. PMID: 24675226; PMCID: PMC4686229.
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    127. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol. 2014; 5:47. Davis PR, Head E. PMID: 24711794; PMCID: PMC3968758.
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    129. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. J Alzheimers Dis. 2014; 42(3):767-75. Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. PMID: 24927707; PMCID: PMC4392817.
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    130. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis. 2014; 42(4):1221-7. Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. PMID: 25024306; PMCID: PMC4198456.
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    131. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014; 39(1):191-210. Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. PMID: 24150111; PMCID: PMC4376359.
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    132. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta. 2013 Aug; 1832(8):1249-59. Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. PMID: 23603808; PMCID: PMC3940071.
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    133. A canine model of human aging and Alzheimer's disease. Biochim Biophys Acta. 2013 Sep; 1832(9):1384-9. Head E. PMID: 23528711; PMCID: PMC3937962.
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    134. Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS One. 2013; 8(3):e59735. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. PMID: 23555764; PMCID: PMC3605408.
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    135. Alzheimer's Disease in Down Syndrome. Eur J Neurodegener Dis. 2012 Dec; 1(3):353-364. Head E, Powell D, Gold BT, Schmitt FA. PMID: 25285303; PMCID: PMC4184282.
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    136. Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. J Cereb Blood Flow Metab. 2013 Feb; 33(2):205-14. Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. PMID: 23149553; PMCID: PMC3564189.
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    137. Aging and down syndrome. Curr Gerontol Geriatr Res. 2012; 2012:412536. Head E, Silverman W, Patterson D, Lott IT. PMID: 22844278; PMCID: PMC3400297.
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    138. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Alzheimer's Disease Genetics Consortium (ADGC), Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. PMID: 22722634; PMCID: PMC3398432.
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    139. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Curr Gerontol Geriatr Res. 2012; 2012:179318. Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. PMID: 22649448; PMCID: PMC3357506.
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    140. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012 Apr 10; 29(6):1054-70. Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. PMID: 22017610; PMCID: PMC3325552.
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    141. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. J Alzheimers Dis. 2012; 32(4):1029-42. Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. PMID: 22886019; PMCID: PMC4006672.
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    142. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol. 2011 Dec; 9(4):651-61. Martin SB, Dowling AL, Head E. PMID: 22654723; PMCID: PMC3263459.
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    143. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem. 2012 Jan; 120(1):135-46. Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. PMID: 22004509.
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    144. BACE2 expression increases in human neurodegenerative disease. Am J Pathol. 2012 Jan; 180(1):337-50. Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. PMID: 22074738; PMCID: PMC3338345.
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    145. Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. BJU Int. 2012 Jun; 109(11):1666-73. Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N'Dow J, Grigor KM, Edinburgh Urological Cancer Group. PMID: 22044434.
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    146. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72. Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. PMID: 21876463; PMCID: PMC3339866.
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    147. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 22046234; PMCID: PMC3202527.
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    148. Antioxidants in the canine model of human aging. Biochim Biophys Acta. 2012 May; 1822(5):685-9. Dowling AL, Head E. PMID: 22005070; PMCID: PMC3291812.
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    149. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta. 2012 Feb; 1822(2):130-8. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. PMID: 22009041; PMCID: PMC3260028.
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    150. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol. 2012 Aug; 15(7):981-7. Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. PMID: 21767440.
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    151. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neurosci Lett. 2011 Aug 26; 501(2):92-5. Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. PMID: 21763754; PMCID: PMC3174091.
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    152. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A. 2011 Aug; 155A(8):1939-48. Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. PMID: 21739598; PMCID: PMC3410645.
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    153. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 21546126; PMCID: PMC3154439.
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    154. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. PMID: 21516511; PMCID: PMC3179861.
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    155. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. PMID: 21460841; PMCID: PMC3090745.
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    156. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. J Alzheimers Dis. 2011; 23(3):399-409. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. PMID: 21116050; PMCID: PMC3219221.
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    157. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res. 2011 Mar; 63(3):172-80. Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. PMID: 21193043; PMCID: PMC3034810.
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    158. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Mol Neurodegener. 2010 Dec 13; 5:57. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. PMID: 21144050; PMCID: PMC3019145.
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    159. Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Ann N Y Acad Sci. 2010 Oct; 1207:58-70. Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. PMID: 20955427; PMCID: PMC2958685.
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    160. Neurobiology of the aging dog. Age (Dordr). 2011 Sep; 33(3):485-96. Head E. PMID: 20845082; PMCID: PMC3168593.
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    161. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. PMID: 20838618; PMCID: PMC2935886.
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    162. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci. 2010 Jul 21; 30(29):9831-9. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. PMID: 20660265; PMCID: PMC3769160.
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    163. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis. 2010 Sep; 39(3):301-10. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. PMID: 20451612; PMCID: PMC2910127.
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    164. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012 Mar; 33(3):546-54. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. PMID: 20447733; PMCID: PMC2935515.
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    165. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. PMID: 20434811; PMCID: PMC2932860.
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    166. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. PMID: 20463402; PMCID: PMC4175722.
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    167. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. J Alzheimers Dis. 2010; 20(2):637-46. Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. PMID: 20164551; PMCID: PMC2903832.
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    168. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis. 2010; 22(1):135-50. Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. PMID: 20847439.
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    169. Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm (Vienna). 2010 Feb; 117(2):227-39. Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ. PMID: 20012109; PMCID: PMC2830004.
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    170. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem. 2010 Jan 08; 285(2):1529-43. Kuhn DE, Nuovo GJ, Terry AV, Martin MM, Malana GE, Sansom SE, Pleister AP, Beck WD, Head E, Feldman DS, Elton TS. PMID: 19897480; PMCID: PMC2801278.
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    171. Nutrition, brain aging, and neurodegeneration. J Neurosci. 2009 Oct 14; 29(41):12795-801. Joseph J, Cole G, Head E, Ingram D. PMID: 19828791; PMCID: PMC6665319.
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    172. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec; 44(12):752-9. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. PMID: 19735717; PMCID: PMC2787885.
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    173. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol. 2009 Nov; 220(1):171-6. Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. PMID: 19703441; PMCID: PMC2761532.
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    174. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis. 2009 Sep; 35(3):352-8. Tomic JL, Pensalfini A, Head E, Glabe CG. PMID: 19523517; PMCID: PMC2725199.
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    175. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol. 2009 Oct; 118(4):505-17. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. PMID: 19360426; PMCID: PMC2737113.
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    176. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. CNS Neurol Disord Drug Targets. 2009 Apr; 8(2):98-113. Vasilevko V, Head E. PMID: 19355931.
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    177. APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology. 2009 Mar 03; 72(9):829-34. Berlau DJ, Corrada MM, Head E, Kawas CH. PMID: 19255410; PMCID: PMC2667799.
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    178. Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease. Int J Physiol Pathophysiol Pharmacol. 2009 Jan 12; 1(1):48-56. Kumasaka DK, Galvan V, Head E, Rohn TT. PMID: 20411026; PMCID: PMC2856934.
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    179. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 2009 Feb 13; 284(7):4230-7. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. PMID: 19098006; PMCID: PMC2640961.
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    180. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec; 15(4):685-707. Cotman CW, Head E. PMID: 19096165.
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    181. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol. 2008 Nov 10; 511(2):257-70. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. PMID: 18792072; PMCID: PMC4105010.
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    182. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15605-10. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. PMID: 18832152; PMCID: PMC2563070.
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    183. Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochem Res. 2009 Apr; 34(4):670-8. Head E. PMID: 18683046; PMCID: PMC4392815.
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    184. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. J Cell Biochem. 2008 Jul 01; 104(4):1232-43. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Head E, Sharman E, Liu J. PMID: 18260126.
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    185. Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Age (Dordr). 2009 Sep; 31(3):211-20. Christie LA, Opii WO, Head E. PMID: 19714491; PMCID: PMC2734239.
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    186. Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? Int J Clin Exp Pathol. 2009; 2(2):108-18. Rohn TT, Head E. PMID: 19079646; PMCID: PMC2583629.
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    211. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. PMID: 16271803.
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    265. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. PMID: 8661247.
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    266. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. PMID: 8744407.
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