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Elizabeth Head

Title(s)Professor, Pathology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1225
ORCID ORCID Icon1115-6396 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, Toronto CanadaBSc08/1991Neuroscience
    University of Toronto, Toronto CanadaMA08/1992Psychology
    University of Toronto, Toronto CanadaPhD01/1997Neuroscience

    Collapse Research 
    Collapse Research Activities and Funding
    Alzheimer Biomarker Consortium - Down syndrome (ABC-DS)
    NIA U19AG068054Jul 1, 2020 - Jun 30, 2025
    Role: MPI
    Role Description: Alzheimer’s disease (AD) is a major public health crisis for our aging population. People with Down Syndrome(DS) are at high risk for AD and because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD. Reliable biomarkers of preclinical AD will enable new options for intervention and promote health for people with DS and in the general population.
    University of California Alzheimer's Disease Center
    NIA P30AG066519Apr 1, 2020 - Mar 31, 2025
    Role: Core Lead REC, Co-Investigator - Neuropathology Core and Down syndrome cohort core
    Role Description: The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving Alzheimer’s disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.
    Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
    NIH/NIA R01AG056998Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Role Description: Preclinical evaluation of tacrolimus in a canine model of Alzheimer’s disease This proposal uses a longitudinal design in to evaluate the safety and efficacy of the calcineurin inhibitor, tacrolimus, in an aging canine model of Alzheimer’s disease
    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2020
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alzheimer's-related cerebrovascular disease in Down syndrome. Ann Neurol. 2020 Sep 18. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 32944999.
      View in: PubMed   Mentions:    Fields:    
    2. Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12092. Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA. PMID: 32875058.
      View in: PubMed   Mentions:
    3. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2020 Aug 11; 101892. Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, Caforio M, Valentini D, Villani A, Locatelli F, Butterfield DA, Head E, Perluigi M, Abisambra JF, Di Domenico F. PMID: 32795489.
      View in: PubMed   Mentions:    Fields:    
    4. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W. PMID: 32775597.
      View in: PubMed   Mentions:
    5. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S. PMID: 32626817.
      View in: PubMed   Mentions:
    6. Biomarkers in Down syndrome can help us understand Alzheimer's disease. Lancet. 2020 06 27; 395(10242):1951-1953. Head E, Ances B. PMID: 32593327.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. PMID: 32544310.
      View in: PubMed   Mentions:    Fields:    
    8. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12028. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N. PMID: 32258359.
      View in: PubMed   Mentions:
    9. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiol Dis. 2020 06; 139:104834. Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. PMID: 32173556.
      View in: PubMed   Mentions:    Fields:    
    10. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiol Dis. 2020 04; 137:104772. Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E. PMID: 31987911.
      View in: PubMed   Mentions: 3     Fields:    
    11. Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review. J Neurodev Disord. 2019 08 30; 11(1):20. Hamburg S, Lowe B, Startin CM, Padilla C, Coppus A, Silverman W, Fortea J, Zaman S, Head E, Handen BL, Lott I, Song W, Strydom A. PMID: 31470792.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease. Dev Neurobiol. 2019 07; 79(7):622-638. Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. PMID: 31419370.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Neuropathological correlates of amyloid PET imaging in Down syndrome. Dev Neurobiol. 2019 07; 79(7):750-766. Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. PMID: 31379087.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    14. Alzheimer's disease in aging Down syndrome. Dev Neurobiol. 2019 07; 79(7):611-612. Cohen AD, Head E, Lee JH. PMID: 31545018.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    15. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol. 2019 03; 15(3):135-147. Lott IT, Head E. PMID: 30733618.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    16. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. J Alzheimers Dis. 2019; 67(1):103-112. Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. PMID: 30452414.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019 02; 15(2):292-312. Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE. PMID: 30555031.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    18. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. PMID: 30800043.
      View in: PubMed   Mentions:
    19. Biliverdin reductase-A impairment links brain insulin resistance with increased Aß production in an animal model of aging: Implications for Alzheimer disease. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3181-3194. Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E. PMID: 29981845.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. Analysis of shared heritability in common disorders of the brain. Science. 2018 06 22; 360(6395). Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono RJ, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, et al. PMID: 29930110.
      View in: PubMed   Mentions: 159     Fields:    Translation:Humans
    21. Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Front Aging Neurosci. 2018; 10:191. Head E, Powell DK, Schmitt FA. PMID: 29977201.
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    22. Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Rep. 2018 06 05; 23(10):2967-2975. Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, Hussaini SA, Marquer C. PMID: 29874583.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Deposition of phosphorylated amyloid-ß in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. PMID: 29740941.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Front Aging Neurosci. 2018; 10:7. Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. PMID: 29441010.
      View in: PubMed   Mentions:
    25. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathol Commun. 2017 Dec 01; 5(1):93. Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. PMID: 29195510.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Down syndrome, beta-amyloid and neuroimaging. Free Radic Biol Med. 2018 01; 114:102-109. Head E, Helman AM, Powell D, Schmitt FA. PMID: 28935420.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    27. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017; 7(14):3573-3584. O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. PMID: 28912896.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    28. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med. 2018 01; 114:94-101. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. PMID: 28807816.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. Alzheimers Dement. 2017 Nov; 13(11):1251-1260. Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernández S, Videla L, Sala I, Sánchez-Saudinós MB, Morenas-Rodriguez E, Ribosa-Nogué R, Illán-Gala I, Gonzalez-Ortiz S, Clarimón J, Schmitt F, Powell DK, Bosch B, Lladó A, Rafii MS, Head E, Molinuevo JL, Blesa R, Videla S, Lleó A, Sánchez-Valle R, Fortea J. PMID: 28463681.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017 06; 54:163-169. LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. PMID: 28385551.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. J Alzheimers Dis. 2017; 56(2):459-470. Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. PMID: 27983553.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    32. HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. Free Radic Biol Med. 2017 10; 111:262-269. Barone E, Head E, Butterfield DA, Perluigi M. PMID: 27838436.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxid Redox Signal. 2017 03 01; 26(7):280-298. Tramutola A, Di Domenico F, Barone E, Arena A, Giorgi A, di Francesco L, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. PMID: 27627691.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016 10 04; 54(3):1251. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL. PMID: 27716679.
      View in: PubMed   Mentions:    Fields:    
    35. Aß vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aß, and microhemorrhages. Neurobiol Aging. 2017 01; 49:86-99. Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E. PMID: 27776266.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Aging Dis. 2016 May; 7(3):267-77. Day RJ, McCarty KL, Ockerse KE, Head E, Rohn TT. PMID: 27330841.
      View in: PubMed   Mentions:
    37. Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Mol Neurodegener. 2016 05 23; 11(1):42. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. PMID: 27216421.
      View in: PubMed   Mentions: 1     Fields:    
    38. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Mol Neurodegener. 2016 04 26; 11:31. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. PMID: 27112350.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain Cogn. 2016 Apr; 104:48-57. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. PMID: 26930369.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016; 52(2):731-45. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL, Annapragada A. PMID: 27031484.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    41. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis. 2016; 52(1):359-371. Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M. PMID: 26967221.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    42. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. Head E, Lott IT, Wilcock DM, Lemere CA. PMID: 26651341.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    43. Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aß Fibrils. ACS Chem Neurosci. 2016 Feb 17; 7(2):171-6. Fosso MY, McCarty K, Head E, Garneau-Tsodikova S, LeVine H. PMID: 26682772.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    44. Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome. Biochim Biophys Acta. 2016 05; 1862(5):909-14. Wilcock DM, Schmitt FA, Head E. PMID: 26593849.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    45. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiol Aging. 2015 Sep; 36(9):2468-74. Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. PMID: 26103884.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812.
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    47. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. J Alzheimers Dis. 2015; 44(4):1107-20. Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. PMID: 25391381.
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    48. Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? J Parkinsons Dis Alzheimers Dis. 2014 Dec 08; 1(1). Rohn TT, McCarty KL, Love JE, Head E. PMID: 25594074.
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    50. Aging in the canine and feline brain. Vet Clin North Am Small Anim Pract. 2014 Nov; 44(6):1113-29. Vite CH, Head E. PMID: 25441628.
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    51. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842.
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    52. Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. Biochem J. 2014 Oct 15; 463(2):177-89. Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M. PMID: 25242166.
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    53. Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome? Alzheimers Res Ther. 2014; 6(5-8):61. Head E, Schmitt FA. PMID: 25478026.
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    54. An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radic Biol Med. 2014 Nov; 76:89-95. Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. PMID: 25151119.
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    55. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab. 2014 Oct; 34(10):1637-45. Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. PMID: 25052558.
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    56. Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta. 2014 Jul; 1842(7):1144-53. Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. PMID: 24735980.
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    60. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014; 39(1):191-210. Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. PMID: 24150111.
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    61. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. J Alzheimers Dis. 2014; 42(3):767-75. Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. PMID: 24927707.
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    62. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis. 2014; 42(4):1221-7. Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. PMID: 25024306.
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    63. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta. 2013 Aug; 1832(8):1249-59. Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. PMID: 23603808.
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    64. A canine model of human aging and Alzheimer's disease. Biochim Biophys Acta. 2013 Sep; 1832(9):1384-9. Head E. PMID: 23528711.
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    65. Bapineuzumab alters aß composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS One. 2013; 8(3):e59735. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. PMID: 23555764.
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    66. Alzheimer's Disease in Down Syndrome. Eur J Neurodegener Dis. 2012 Dec; 1(3):353-364. Head E, Powell D, Gold BT, Schmitt FA. PMID: 25285303.
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    70. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012 Apr 10; 29(6):1054-70. Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. PMID: 22017610.
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    71. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. J Alzheimers Dis. 2012; 32(4):1029-42. Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. PMID: 22886019.
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    75. Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. BJU Int. 2012 Jun; 109(11):1666-73. Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N'Dow J, Grigor KM. PMID: 22044434.
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    77. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72. Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. PMID: 21876463.
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    88. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aß oligomers. Mol Neurodegener. 2010 Dec 13; 5:57. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. PMID: 21144050.
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    91. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. PMID: 20838618.
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    172. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
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    173. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. PMID: 12213643.
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    174. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. PMID: 12392784.
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    175. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002 Jul; 82(2):375-81. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. PMID: 12124438.
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    176. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. PMID: 12049325.
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    177. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. Su JH, Kesslak JP, Head E, Cotman CW. PMID: 12070657.
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    178. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. PMID: 11854529.
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    179. Insights into Abeta and presenilin from a canine model of human brain aging. Neurobiol Dis. 2002 Feb; 9(1):1-10. Head E, Torp R. PMID: 11848680.
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    180. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct; 8(5):792-806. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. PMID: 11592849.
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    181. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001 Apr; 8(2):252-65. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. PMID: 11300721.
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    182. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol. 2001 Jan; 158(1):189-98. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. PMID: 11141492.
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    183. Down syndrome and Alzheimer's disease: a link between development and aging. Ment Retard Dev Disabil Res Rev. 2001; 7(3):172-8. Lott IT, Head E. PMID: 11553933.
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    184. Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther. 2001; 2(3):247-60. Head E. PMID: 19746668.
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    185. Canine cognition, aging and neuropathology. Introduction. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):671-3. Head E, Cotman CW, Milgram NW. PMID: 11191707.
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    186. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):777-86. Head E, Thornton PL, Tong L, Cotman CW. PMID: 11191712.
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    187. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Exp Neurol. 2000 May; 163(1):111-22. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. PMID: 10785449.
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    188. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000 Jan-Feb; 21(1):89-96. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. PMID: 10794853.
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    189. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol. 1999 Oct; 56(10):1233-9. Johnson JK, Head E, Kim R, Starr A, Cotman CW. PMID: 10520939.
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    190. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Exp Neurol. 1999 Jun; 157(2):277-88. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. PMID: 10364440.
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    191. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging. 1998 Sep-Oct; 19(5):415-25. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. PMID: 9880044.
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    192. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging. 1998 Sep-Oct; 19(5):479-85. Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. PMID: 9880050.
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    193. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 07; 774(1-2):35-43. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. PMID: 9452189.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    194. Open field activity and human interaction as a function of age and breed in dogs. Physiol Behav. 1997 Nov; 62(5):963-71. Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. PMID: 9333188.
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    195. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. PMID: 8661247.
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    196. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. PMID: 8744407.
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