Elizabeth Head

Title(s)Professor, Pathology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1225
ORCID ORCID Icon1115-6396 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, Toronto CanadaBSc08/1991Neuroscience
    University of Toronto, Toronto CanadaMA08/1992Psychology
    University of Toronto, Toronto CanadaPhD01/1997Neuroscience

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
    NIH U19AG068054Sep 30, 2020 - Aug 31, 2025
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down syndrome (ABC-DS)
    NIA U19AG068054Jul 1, 2020 - Jun 30, 2025
    Role: MPI
    Role Description: Alzheimer’s disease (AD) is a major public health crisis for our aging population. People with Down Syndrome(DS) are at high risk for AD and because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD. Reliable biomarkers of preclinical AD will enable new options for intervention and promote health for people with DS and in the general population.
    University of California Alzheimer's Disease Center
    NIA P30AG066519Apr 1, 2020 - Mar 31, 2025
    Role: Core Lead REC, Co-Investigator - Neuropathology Core and Down syndrome cohort core
    Role Description: The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving Alzheimer’s disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.
    Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
    NIH R01AG056998Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Role Description: Preclinical evaluation of tacrolimus in a canine model of Alzheimer’s disease This proposal uses a longitudinal design in to evaluate the safety and efficacy of the calcineurin inhibitor, tacrolimus, in an aging canine model of Alzheimer’s disease
    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease. Nat Genet. 2021 Jul 08. Morabito S, Miyoshi E, Michael N, Shahin S, Martini AC, Head E, Silva J, Leavy K, Perez-Rosendahl M, Swarup V. PMID: 34239132.
      View in: PubMed   Mentions:    Fields:    
    2. APOE e4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. JAMA Neurol. 2021 Jul 06. Lemere CA, Head E, Holtzman DM. PMID: 34228117.
      View in: PubMed   Mentions:    Fields:    
    3. Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain. J Neurosci. 2021 Jun 09; 41(23):5124-5133. Radhakrishnan H, Ubele MF, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E. PMID: 33952632.
      View in: PubMed   Mentions:    Fields:    
    4. Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease. Alzheimers Dement (Amst). 2021; 13(1):e12184. Aschenbrenner AJ, Baksh RA, Benejam B, Beresford-Webb JA, Coppus A, Fortea J, Handen BL, Hartley S, Head E, Jaeger J, Levin J, Loosli SV, Rebillat AS, Sacco S, Schmitt FA, Thurlow KE, Zaman S, Hassenstab J, Strydom A. PMID: 33969175.
      View in: PubMed   Mentions:
    5. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. PMID: 33924960.
      View in: PubMed   Mentions:
    6. Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021; 5(3-4):99-129. Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS. PMID: 34268067.
      View in: PubMed   Mentions:
    7. Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. J Alzheimers Dis. 2021; 79(2):671-681. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O'Bryant S, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) . PMID: 33337378.
      View in: PubMed   Mentions: 1     Fields:    
    8. Longitudinal assessment of dementia measures in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12075. Koehl L, Harp J, Van Pelt KL, Head E, Schmitt FA. PMID: 33225040.
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    9. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12062. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O'Bryant S. PMID: 33134477.
      View in: PubMed   Mentions:
    10. Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12113. Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. PMID: 33088896.
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    11. Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Ann Neurol. 2020 12; 88(6):1165-1177. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 32944999.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12092. Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA. PMID: 32875058.
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    13. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2021 01; 196:101892. Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, Caforio M, Valentini D, Villani A, Locatelli F, Butterfield DA, Head E, Perluigi M, Abisambra JF, Di Domenico F. PMID: 32795489.
      View in: PubMed   Mentions: 5     Fields:    
    14. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) . PMID: 32775597.
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    15. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS) . PMID: 32626817.
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    16. Biomarkers in Down syndrome can help us understand Alzheimer's disease. Lancet. 2020 06 27; 395(10242):1951-1953. Head E, Ances B. PMID: 32593327.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. PMID: 32544310.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12028. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators . PMID: 32258359.
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    19. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiol Dis. 2020 06; 139:104834. Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. PMID: 32173556.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiol Dis. 2020 04; 137:104772. Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E. PMID: 31987911.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    21. Brain-Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. Front Neurosci. 2019; 13:1189. Thalman SW, Powell DK, Ubele M, Norris CM, Head E, Lin AL. PMID: 31749679.
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    22. Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review. J Neurodev Disord. 2019 08 30; 11(1):20. Hamburg S, Lowe B, Startin CM, Padilla C, Coppus A, Silverman W, Fortea J, Zaman S, Head E, Handen BL, Lott I, Song W, Strydom A. PMID: 31470792.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease. Dev Neurobiol. 2019 07; 79(7):622-638. Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. PMID: 31419370.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    24. Neuropathological correlates of amyloid PET imaging in Down syndrome. Dev Neurobiol. 2019 07; 79(7):750-766. Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. PMID: 31379087.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    25. Alzheimer's disease in aging Down syndrome. Dev Neurobiol. 2019 07; 79(7):611-612. Cohen AD, Head E, Lee JH. PMID: 31545018.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    26. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol. 2019 03; 15(3):135-147. Lott IT, Head E. PMID: 30733618.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    27. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. J Alzheimers Dis. 2019; 67(1):103-112. Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. PMID: 30452414.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019 02; 15(2):292-312. Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association . PMID: 30555031.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    29. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. PMID: 30800043.
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    30. Biliverdin reductase-A impairment links brain insulin resistance with increased Aß production in an animal model of aging: Implications for Alzheimer disease. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3181-3194. Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E. PMID: 29981845.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. Analysis of shared heritability in common disorders of the brain. Science. 2018 06 22; 360(6395). Brainstorm Consortium , Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono RJ, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, et al. PMID: 29930110.
      View in: PubMed   Mentions: 284     Fields:    Translation:Humans
    32. Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Front Aging Neurosci. 2018; 10:191. Head E, Powell DK, Schmitt FA. PMID: 29977201.
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    33. Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Rep. 2018 06 05; 23(10):2967-2975. Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, Hussaini SA, Marquer C. PMID: 29874583.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    34. Deposition of phosphorylated amyloid-ß in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. PMID: 29740941.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Front Aging Neurosci. 2018; 10:7. Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. PMID: 29441010.
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    36. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathol Commun. 2017 Dec 01; 5(1):93. Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. PMID: 29195510.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    37. Down syndrome, beta-amyloid and neuroimaging. Free Radic Biol Med. 2018 01; 114:102-109. Head E, Helman AM, Powell D, Schmitt FA. PMID: 28935420.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    38. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017; 7(14):3573-3584. O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. PMID: 28912896.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    39. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med. 2018 01; 114:94-101. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. PMID: 28807816.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    40. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. Alzheimers Dement. 2017 Nov; 13(11):1251-1260. Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernández S, Videla L, Sala I, Sánchez-Saudinós MB, Morenas-Rodriguez E, Ribosa-Nogué R, Illán-Gala I, Gonzalez-Ortiz S, Clarimón J, Schmitt F, Powell DK, Bosch B, Lladó A, Rafii MS, Head E, Molinuevo JL, Blesa R, Videla S, Lleó A, Sánchez-Valle R, Fortea J. PMID: 28463681.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    41. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017 06; 54:163-169. LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. PMID: 28385551.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. J Alzheimers Dis. 2017; 56(2):459-470. Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. PMID: 27983553.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    43. HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. Free Radic Biol Med. 2017 10; 111:262-269. Barone E, Head E, Butterfield DA, Perluigi M. PMID: 27838436.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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    52. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis. 2016; 52(1):359-371. Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M. PMID: 26967221.
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    58. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. J Alzheimers Dis. 2015; 44(4):1107-20. Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. PMID: 25391381.
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    66. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab. 2014 Oct; 34(10):1637-45. Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. PMID: 25052558.
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    165. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004 May; 39(5):753-65. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. PMID: 15130670.
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    166. Down syndrome and beta-amyloid deposition. Curr Opin Neurol. 2004 Apr; 17(2):95-100. Head E, Lott IT. PMID: 15021233.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    167. Nutraceuticals, aging, and cognitive dysfunction. Vet Clin North Am Small Anim Pract. 2004 Jan; 34(1):217-28. Head E, Zicker SC. PMID: 15032129.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    168. Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord. 2004; 17(4):360-7. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. PMID: 15178954.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    169. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. Zhao M, Su J, Head E, Cotman CW. PMID: 14678756.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    170. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. Eur J Immunol. 2003 Dec; 33(12):3232-41. Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. PMID: 14635031.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCellsPHPublic Health
    171. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. PMID: 14570555.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    172. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. Bi X, Head E, Cotman CW, Lynch G. PMID: 12900930.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    173. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. PMID: 12931965.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    174. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. PMID: 12702875.
      View in: PubMed   Mentions: 1262     Fields:    Translation:HumansAnimalsCells
    175. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. PMID: 12551965.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    176. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. PMID: 12505426.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    177. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
      View in: PubMed   Mentions: 19     Fields:    
    178. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. PMID: 12480733.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    179. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. PMID: 12213643.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    180. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. PMID: 12392784.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    181. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. PMID: 12049325.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    182. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. Su JH, Kesslak JP, Head E, Cotman CW. PMID: 12070657.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    183. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. PMID: 11854529.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    184. Insights into Abeta and presenilin from a canine model of human brain aging. Neurobiol Dis. 2002 Feb; 9(1):1-10. Head E, Torp R. PMID: 11848680.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
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