Elizabeth Head

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1225
ORCID ORCID Icon1115-6396 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, Toronto CanadaBSc08/1991Neuroscience
    University of Toronto, Toronto CanadaMA08/1992Psychology
    University of Toronto, Toronto CanadaPhD01/1997Neuroscience

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Training in Translational ADRD Neuroscience (TITAN)
    NIH T32AG073088Sep 1, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
    NIH U19AG068054Sep 30, 2020 - Aug 31, 2025
    Role: Co-Principal Investigator
    Alzheimer Biomarker Consortium - Down syndrome (ABC-DS)
    NIA U19AG068054Jul 1, 2020 - Jun 30, 2025
    Role: MPI
    Description: Alzheimer’s disease (AD) is a major public health crisis for our aging population. People with Down Syndrome(DS) are at high risk for AD and because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD. Reliable biomarkers of preclinical AD will enable new options for intervention and promote health for people with DS and in the general population.
    University of California Alzheimer's Disease Center
    NIA P30AG066519Apr 1, 2020 - Mar 31, 2025
    Role: Core Lead REC, Co-Investigator - Neuropathology Core and Down syndrome cohort core
    Description: The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving Alzheimer’s disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.
    Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
    NIH R01AG056998Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Description: Preclinical evaluation of tacrolimus in a canine model of Alzheimer’s disease This proposal uses a longitudinal design in to evaluate the safety and efficacy of the calcineurin inhibitor, tacrolimus, in an aging canine model of Alzheimer’s disease
    Biomarkers of Alzheimer's Disease in Adults with Down Syndrome
    NIH U01AG051412Sep 30, 2015 - Apr 30, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Age-related brain atrophy and the positive effects of behavioral enrichment in middle-aged beagles. J Neurosci. 2024 Apr 01. Noche JA, Radhakrishnan H, Ubele MF, Boaz K, Mefford JL, Jones ED, Perpich JA, McCarty K, Meacham B, Smiley J, Bailey SAB, Puskás LG, Powell DK, Sordo L, Phelan MJ, Norris CM, Head E, Stark CEL. PMID: 38561226.
      View in: PubMed   Mentions:    Fields:    
    2. A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease. bioRxiv. 2024 Mar 14. Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Finkbeiner S, Head E, Liu Y, Jiang P. PMID: 38559257; PMCID: PMC10979994.
      View in: PubMed   Mentions:
    3. Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement. 2024 Feb 21. Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long-Life Family Study (LLFS), Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS). PMID: 38380866.
      View in: PubMed   Mentions:    Fields:    
    4. Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12542. DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O'Bryant S, Yassa MA. PMID: 38348178; PMCID: PMC10859879.
      View in: PubMed   Mentions:
    5. Down Syndrome Biobank Consortium: A perspective. Alzheimers Dement. 2024 Mar; 20(3):2262-2272. Aldecoa I, Barroeta I, Carroll SL, Fortea J, Gilmore A, Ginsberg SD, Guzman SJ, Hamlett ED, Head E, Perez SE, Potter H, Molina-Porcel L, Raha-Chowdhury R, Wisniewski T, Yong WH, Zaman S, Ghosh S, Mufson EJ, Granholm AC. PMID: 38270275.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue. ACS Cent Sci. 2024 Jan 24; 10(1):104-121. Kreutzer AG, Parrocha CMT, Haerianardakani S, Guaglianone G, Nguyen JT, Diab MN, Yong W, Perez-Rosendahl M, Head E, Nowick JS. PMID: 38292607; PMCID: PMC10823522.
      View in: PubMed   Mentions:
    7. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv. 2023 Nov 30. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 38076904; PMCID: PMC10705616.
      View in: PubMed   Mentions:
    8. Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv. 2023 Oct 26. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards N, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 37961444; PMCID: PMC10635215.
      View in: PubMed   Mentions:
    9. Alzheimer's disease ferroptotic associations with oxidative damage and neuronal loss. bioRxiv. 2023 Sep 19. Thorwald MA, Godoy-Lugo JA, Silva J, Head E, O'Day PA, Morgan TE, Forman HJ, Finch CE. PMID: 37034750; PMCID: PMC10081222.
      View in: PubMed   Mentions:
    10. Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial. Sci Data. 2023 07 29; 10(1):503. Yoo HJ, Nashiro K, Min J, Cho C, Mercer N, Bachman SL, Nasseri P, Dutt S, Porat S, Choi P, Zhang Y, Grigoryan V, Feng T, Thayer JF, Lehrer P, Chang C, Stanley JA, Head E, Rouanet J, Marmarelis VZ, Narayanan S, Wisnowski J, Nation DA, Mather M. PMID: 37516756; PMCID: PMC10387077.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease. bioRxiv. 2023 Jul 26. Miyoshi E, Morabito S, Henningfield CM, Rahimzadeh N, Kiani Shabestari S, Das S, Michael N, Reese F, Shi Z, Cao Z, Scarfone V, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M, Head E, Green KN, Swarup V. PMID: 37546983; PMCID: PMC10402031.
      View in: PubMed   Mentions:
    12. Plasma NT1-tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimers Dement. 2023 Dec; 19(12):5755-5764. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) investigators. PMID: 37438872; PMCID: PMC10784408.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, et al. PMID: 37461624; PMCID: PMC10350126.
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    14. Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old. Acta Neuropathol. 2023 09; 146(3):415-432. Sordo L, Qian T, Bukhari SA, Nguyen KM, Woodworth DC, Head E, Kawas CH, Corrada MM, Montine TJ, Sajjadi SA. PMID: 37382680; PMCID: PMC10412485.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia. Neurobiol Aging. 2023 08; 128:43-48. Kapoor A, Gaubert A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Nguyen A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shenasa F, Rodgers KE, Martini AC, Head E, Nation DA. PMID: 37156179; PMCID: PMC10852216.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12419. Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. PMID: 37035460; PMCID: PMC10075195.
      View in: PubMed   Mentions: 2  
    17. Increased plasma DYRK1A with aging may protect against neurodegenerative diseases. Transl Psychiatry. 2023 04 04; 13(1):111. Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. PMID: 37015911; PMCID: PMC10073199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts. medRxiv. 2023 Mar 10. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) investigators. PMID: 36945447; PMCID: PMC10029060.
      View in: PubMed   Mentions:
    19. Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults. Sci Rep. 2023 03 09; 13(1):3967. Min J, Rouanet J, Martini AC, Nashiro K, Yoo HJ, Porat S, Cho C, Wan J, Cole SW, Head E, Nation DA, Thayer JF, Mather M. PMID: 36894565; PMCID: PMC9998394.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2023 01; 22(1):55-65. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome, Dominantly Inherited Alzheimer Network. PMID: 36517172; PMCID: PMC9979840.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Weight Loss and Alzheimer's Disease in Down Syndrome. J Alzheimers Dis. 2023; 91(3):1215-1227. Fleming V, Helsel BC, Ptomey LT, Rosas HD, Handen B, Laymon C, Christian BT, Head E, Mapstone M, Lai F, Krinsky-McHale S, Zaman S, Ances BM, Lee JH, Hartley SL, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) Consortium. PMID: 36565120; PMCID: PMC9940268.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome. J Alzheimers Dis. 2023; 95(1):213-225. Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 37482997; PMCID: PMC10578224.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Amyloid futures in the expanding pathology of brain aging and dementia. Alzheimers Dement. 2023 06; 19(6):2605-2617. Thorwald MA, Silva J, Head E, Finch CE. PMID: 36536382; PMCID: PMC10271937.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116. Chen XQ, Zuo X, Becker A, Head E, Mobley WC. PMID: 36370135; PMCID: PMC10175517.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    25. Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society. Mol Syndromol. 2023 Apr; 14(2):89-100. Hamlett ED, Flores-Aguilar L, Handen B, Potier MC, Granholm AC, Sherman S, Puig V, Santoro JD, Carmona-Iragui M, Rebillat AS, Head E, Strydom A, Busciglio J. PMID: 37064334; PMCID: PMC10090974.
      View in: PubMed   Mentions:
    26. Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 2022 11 16; 119(46):e2212954119. Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. PMID: 36343257; PMCID: PMC9674250.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults. Sci Rep. 2022 10 13; 12(1):17197. Sible IJ, Yew B, Jang JY, Alitin JPM, Li Y, Gaubert A, Nguyen A, Dutt S, Blanken AE, Ho JK, Marshall AJ, Kapoor A, Shenasa F, Rodgers KE, Sturm VE, Head E, Martini A, Nation DA. PMID: 36229634; PMCID: PMC9561652.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome. Front Neurosci. 2022; 16:954999. Andrews EJ, Martini AC, Head E. PMID: 36033603; PMCID: PMC9411995.
      View in: PubMed   Mentions: 5  
    29. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 2022 07 07; 29(7):1135-1153.e8. Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, Jiang P. PMID: 35803230; PMCID: PMC9345168.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    30. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022 06 23; 185(13):2213-2233.e25. Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. PMID: 35750033; PMCID: PMC9340815.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    31. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Rep. 2022 06 14; 39(11):110961. Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M. PMID: 35705056; PMCID: PMC9285116.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Commentary on Oeckl et al., "Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181". Ann Neurol. 2022 07; 92(1):3-5. Head E, Zetterberg H. PMID: 35599543; PMCID: PMC9348592.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12324. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB, Alzheimer's Biomarkers Consortium. PMID: 35634535; PMCID: PMC9131930.
      View in: PubMed   Mentions: 1  
    34. A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease. Geroscience. 2022 06; 44(3):1525-1550. Macciardi F, Giulia Bacalini M, Miramontes R, Boattini A, Taccioli C, Modenini G, Malhas R, Anderlucci L, Gusev Y, Gross TJ, Padilla RM, Fiandaca MS, Head E, Guffanti G, Federoff HJ, Mapstone M. PMID: 35585302; PMCID: PMC9213607.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum. Sleep Adv. 2022; 3(1):zpac013. Lao P, Zimmerman ME, Hartley SL, Gutierrez J, Keator D, Igwe KC, Laing KK, Cotton-Samuel D, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Diana Rosas H, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 35669316; PMCID: PMC9154738.
      View in: PubMed   Mentions: 2  
    36. Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome. Neuron. 2022 07 06; 110(13):2063-2079. Martini AC, Gross TJ, Head E, Mapstone M. PMID: 35472307; PMCID: PMC9262826.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group. J Neurodev Disord. 2022 03 23; 14(1):22. Baumer NT, Becker ML, Capone GT, Egan K, Fortea J, Handen BL, Head E, Hendrix JE, Litovsky RY, Strydom A, Tapia IE, Rafii MS. PMID: 35321660; PMCID: PMC8942061.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Probing the proteome to explore potential correlates of increased Alzheimer's-related cerebrovascular disease in adults with Down syndrome. Alzheimers Dement. 2022 10; 18(10):1744-1753. Moni F, Petersen ME, Zhang F, Lao PJ, Zimmerman ME, Gu Y, Gutierrez J, Rizvi B, Laing KK, Igwe KC, Sathishkumar M, Keator D, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, O'Bryant S, Brickman AM. PMID: 35212182; PMCID: PMC9399305.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Disabil Health J. 2022 07; 15(3):101278. Hartley SL, Fleming V, Piro-Gambetti B, Cohen A, Ances BM, Yassa MA, Brickman AM, Handen BL, Head E, Mapstone M, Christian BT, Lott IT, Doran E, Zaman S, Krinsky-McHale S, Schmitt FA, Hom C, Schupf N, ABC-DS Group. PMID: 35256308; PMCID: PMC8849846.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    40. Primitive Reflexes and Dementia in Adults With Down Syndrome. Neurol Clin Pract. 2022 Feb; 12(1):6-13. Harp J, Koehl L, Van Pelt K, Head E, Jicha G, Robertson W, Lightner D, Lott I, Schmitt F. PMID: 36157622; PMCID: PMC9491499.
      View in: PubMed   Mentions:
    41. Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer's Disease in People with Down Syndrome. J Alzheimers Dis. 2022; 85(1):153-165. DiProspero ND, Keator DB, Phelan M, van Erp TGM, Doran E, Powell DK, Van Pelt KL, Schmitt FA, Head E, Lott IT, Yassa MA. PMID: 34776436; PMCID: PMC9017677.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2022 06; 18(6):1203-1234. Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. PMID: 34757693; PMCID: PMC9085977.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    43. Alzheimer's disease associated with Down syndrome: a genetic form of dementia. Lancet Neurol. 2021 11; 20(11):930-942. Fortea J, Zaman SH, Hartley S, Rafii MS, Head E, Carmona-Iragui M. PMID: 34687637; PMCID: PMC9387748.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    44. Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome. Brain Sci. 2021 Aug 25; 11(9). Harp JP, Koehl LM, Pelt KLV, Hom CL, Doran E, Head E, Lott IT, Schmitt FA. PMID: 34573150; PMCID: PMC8468129.
      View in: PubMed   Mentions: 3  
    45. Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer's Disease. Front Aging Neurosci. 2021; 13:728739. Pivtoraiko VN, Racic T, Abrahamson EE, Villemagne VL, Handen BL, Lott IT, Head E, Ikonomovic MD. PMID: 34489686; PMCID: PMC8416541.
      View in: PubMed   Mentions:
    46. APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All. JAMA Neurol. 2021 08 01; 78(8):913-915. Lemere CA, Head E, Holtzman DM. PMID: 34228117.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study. Lancet Neurol. 2021 08; 20(8):605-614. Carmona-Iragui M, Alcolea D, Barroeta I, Videla L, Muñoz L, Van Pelt KL, Schmitt FA, Lightner DD, Koehl LM, Jicha G, Sacco S, Mircher C, Pape SE, Hithersay R, Clare ICH, Holland AJ, Nübling G, Levin J, Zaman SH, Strydom A, Rebillat AS, Head E, Blesa R, Lleó A, Fortea J. PMID: 34302785; PMCID: PMC8852333.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    48. Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease. Nat Genet. 2021 08; 53(8):1143-1155. Morabito S, Miyoshi E, Michael N, Shahin S, Martini AC, Head E, Silva J, Leavy K, Perez-Rosendahl M, Swarup V. PMID: 34239132; PMCID: PMC8766217.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    49. Neuropathology of Aging in Cats and its Similarities to Human Alzheimer's Disease. Front Aging. 2021; 2:684607. Sordo L, Martini AC, Houston EF, Head E, Gunn-Moore D. PMID: 35822024; PMCID: PMC9261448.
      View in: PubMed   Mentions: 4  
    50. Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain. J Neurosci. 2021 06 09; 41(23):5124-5133. Radhakrishnan H, Ubele MF, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E. PMID: 33952632; PMCID: PMC8197636.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    51. Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease. Alzheimers Dement (Amst). 2021; 13(1):e12184. Aschenbrenner AJ, Baksh RA, Benejam B, Beresford-Webb JA, Coppus A, Fortea J, Handen BL, Hartley S, Head E, Jaeger J, Levin J, Loosli SV, Rebillat AS, Sacco S, Schmitt FA, Thurlow KE, Zaman S, Hassenstab J, Strydom A. PMID: 33969175; PMCID: PMC8088591.
      View in: PubMed   Mentions: 11  
    52. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. PMID: 33924960; PMCID: PMC8124643.
      View in: PubMed   Mentions: 10  
    53. Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021; 5(3-4):99-129. Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS. PMID: 34268067; PMCID: PMC8279178.
      View in: PubMed   Mentions: 21  
    54. Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. J Alzheimers Dis. 2021; 79(2):671-681. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O'Bryant S, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS). PMID: 33337378; PMCID: PMC8273927.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    55. Longitudinal assessment of dementia measures in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12075. Koehl L, Harp J, Van Pelt KL, Head E, Schmitt FA. PMID: 33225040; PMCID: PMC7666427.
      View in: PubMed   Mentions: 11  
    56. The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12062. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O'Bryant S. PMID: 33134477; PMCID: PMC7588820.
      View in: PubMed   Mentions: 15  
    57. Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12113. Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. PMID: 33088896; PMCID: PMC7560512.
      View in: PubMed   Mentions: 27  
    58. Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Ann Neurol. 2020 12; 88(6):1165-1177. Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, Rosas HD, Silverman W, Lott IT, Schupf N, Brickman AM. PMID: 32944999; PMCID: PMC7729262.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    59. Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12092. Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA. PMID: 32875058; PMCID: PMC7447907.
      View in: PubMed   Mentions: 3  
    60. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2021 01; 196:101892. Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, Caforio M, Valentini D, Villani A, Locatelli F, Butterfield DA, Head E, Perluigi M, Abisambra JF, Di Domenico F. PMID: 32795489.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    61. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). PMID: 32775597; PMCID: PMC7396809.
      View in: PubMed   Mentions: 39  
    62. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 32626817; PMCID: PMC7327223.
      View in: PubMed   Mentions: 13  
    63. Biomarkers in Down syndrome can help us understand Alzheimer's disease. Lancet. 2020 06 27; 395(10242):1951-1953. Head E, Ances B. PMID: 32593327.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 07; 16(7):1065-1077. Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm AC, Rosas HD, Strydom A, Whitten MS, Rafii MS. PMID: 32544310; PMCID: PMC8865308.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    65. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12028. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators. PMID: 32258359; PMCID: PMC7131985.
      View in: PubMed   Mentions: 11  
    66. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiol Dis. 2020 06; 139:104834. Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. PMID: 32173556; PMCID: PMC7486698.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    67. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiol Dis. 2020 04; 137:104772. Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E. PMID: 31987911.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    68. Brain-Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. Front Neurosci. 2019; 13:1189. Thalman SW, Powell DK, Ubele M, Norris CM, Head E, Lin AL. PMID: 31749679; PMCID: PMC6848028.
      View in: PubMed   Mentions: 4  
    69. Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review. J Neurodev Disord. 2019 08 30; 11(1):20. Hamburg S, Lowe B, Startin CM, Padilla C, Coppus A, Silverman W, Fortea J, Zaman S, Head E, Handen BL, Lott I, Song W, Strydom A. PMID: 31470792; PMCID: PMC6716931.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    70. Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease. Dev Neurobiol. 2019 07; 79(7):622-638. Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. PMID: 31419370.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    71. Neuropathological correlates of amyloid PET imaging in Down syndrome. Dev Neurobiol. 2019 07; 79(7):750-766. Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. PMID: 31379087; PMCID: PMC6892598.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    72. Alzheimer's disease in aging Down syndrome. Dev Neurobiol. 2019 07; 79(7):611-612. Cohen AD, Head E, Lee JH. PMID: 31545018.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    73. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol. 2019 03; 15(3):135-147. Lott IT, Head E. PMID: 30733618; PMCID: PMC8061428.
      View in: PubMed   Mentions: 139     Fields:    Translation:Humans
    74. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. J Alzheimers Dis. 2019; 67(1):103-112. Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. PMID: 30452414; PMCID: PMC6424116.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    75. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019 02; 15(2):292-312. Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association. PMID: 30555031; PMCID: PMC6368893.
      View in: PubMed   Mentions: 212     Fields:    Translation:Humans
    76. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. PMID: 30800043; PMCID: PMC6381890.
      View in: PubMed   Mentions: 4  
    77. Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3181-3194. Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E. PMID: 29981845.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    78. Analysis of shared heritability in common disorders of the brain. Science. 2018 06 22; 360(6395). Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono RJ, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, et al. PMID: 29930110; PMCID: PMC6097237.
      View in: PubMed   Mentions: 685     Fields:    Translation:Humans
    79. Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Front Aging Neurosci. 2018; 10:191. Head E, Powell DK, Schmitt FA. PMID: 29977201; PMCID: PMC6021507.
      View in: PubMed   Mentions: 11  
    80. Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Rep. 2018 06 05; 23(10):2967-2975. Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, Hussaini SA, Marquer C. PMID: 29874583; PMCID: PMC6040810.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    81. Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. PMID: 29740941; PMCID: PMC8028592.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    82. An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Front Aging Neurosci. 2018; 10:7. Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. PMID: 29441010; PMCID: PMC5797595.
      View in: PubMed   Mentions: 9  
    83. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathol Commun. 2017 Dec 01; 5(1):93. Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. PMID: 29195510; PMCID: PMC5709935.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    84. Down syndrome, beta-amyloid and neuroimaging. Free Radic Biol Med. 2018 01; 114:102-109. Head E, Helman AM, Powell D, Schmitt FA. PMID: 28935420; PMCID: PMC5748259.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    85. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 2017; 7(14):3573-3584. O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. PMID: 28912896; PMCID: PMC5596444.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    86. mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radic Biol Med. 2018 01; 114:94-101. Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. PMID: 28807816; PMCID: PMC5748251.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    87. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. Alzheimers Dement. 2017 Nov; 13(11):1251-1260. Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernández S, Videla L, Sala I, Sánchez-Saudinós MB, Morenas-Rodriguez E, Ribosa-Nogué R, Illán-Gala I, Gonzalez-Ortiz S, Clarimón J, Schmitt F, Powell DK, Bosch B, Lladó A, Rafii MS, Head E, Molinuevo JL, Blesa R, Videla S, Lleó A, Sánchez-Valle R, Fortea J. PMID: 28463681; PMCID: PMC5660938.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    88. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiol Aging. 2017 06; 54:163-169. LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. PMID: 28385551; PMCID: PMC5638297.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    89. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. J Alzheimers Dis. 2017; 56(2):459-470. Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. PMID: 27983553; PMCID: PMC5662115.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    90. HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. Free Radic Biol Med. 2017 10; 111:262-269. Barone E, Head E, Butterfield DA, Perluigi M. PMID: 27838436; PMCID: PMC5639937.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    91. Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxid Redox Signal. 2017 03 01; 26(7):280-298. Tramutola A, Di Domenico F, Barone E, Arena A, Giorgi A, di Francesco L, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. PMID: 27627691; PMCID: PMC5327052.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    92. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016 10 04; 54(3):1251. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL. PMID: 27716679.
      View in: PubMed   Mentions:    Fields:    
    93. Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages. Neurobiol Aging. 2017 01; 49:86-99. Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, Kryscio R, Wilcock DM, Barrett EG, Head E. PMID: 27776266; PMCID: PMC5154836.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    94. Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Aging Dis. 2016 May; 7(3):267-77. Day RJ, McCarty KL, Ockerse KE, Head E, Rohn TT. PMID: 27330841; PMCID: PMC4898923.
      View in: PubMed   Mentions: 3  
    95. Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Mol Neurodegener. 2016 05 23; 11(1):42. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. PMID: 27216421; PMCID: PMC4877764.
      View in: PubMed   Mentions: 1     Fields:    
    96. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Mol Neurodegener. 2016 04 26; 11:31. Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, Johns H, Karydas A, Knopman DS, Loboda A, Masliah E, Narasimhan R, Petersen RC, Podtelezhnikov A, Pradhan S, Rademakers R, Sun CH, Younkin SG, Miller BL, Ideker T, Wyss-Coray T. PMID: 27112350; PMCID: PMC4845325.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    97. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain Cogn. 2016 Apr; 104:48-57. Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. PMID: 26930369; PMCID: PMC4801771.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    98. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis. 2016; 52(1):359-371. Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Brokeaart D, Blarzino C, Head E, Butterfield DA, Perluigi M. PMID: 26967221; PMCID: PMC4968087.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    99. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis. 2016; 52(2):731-45. Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL, Annapragada A. PMID: 27031484; PMCID: PMC4931553.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    100. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Curr Alzheimer Res. 2016; 13(1):18-29. Head E, Lott IT, Wilcock DM, Lemere CA. PMID: 26651341; PMCID: PMC4948181.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    101. Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils. ACS Chem Neurosci. 2016 Feb 17; 7(2):171-6. Fosso MY, McCarty K, Head E, Garneau-Tsodikova S, LeVine H. PMID: 26682772.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    102. Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome. Biochim Biophys Acta. 2016 05; 1862(5):909-14. Wilcock DM, Schmitt FA, Head E. PMID: 26593849; PMCID: PMC4821721.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    103. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiol Aging. 2015 Sep; 36(9):2468-74. Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. PMID: 26103884; PMCID: PMC4602365.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    104. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812; PMCID: PMC4324097.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    105. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. J Alzheimers Dis. 2015; 44(4):1107-20. Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. PMID: 25391381; PMCID: PMC4677575.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    106. Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? J Parkinsons Dis Alzheimers Dis. 2014 Dec 08; 1(1). Rohn TT, McCarty KL, Love JE, Head E. PMID: 25594074; PMCID: PMC4291017.
      View in: PubMed   Mentions: 15  
    107. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PLoS One. 2014; 9(11):e111899. Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H, Spires-Jones TL, Catalano SM. PMID: 25390692; PMCID: PMC4229119.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    108. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842; PMCID: PMC4314944.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    109. Aging in the canine and feline brain. Vet Clin North Am Small Anim Pract. 2014 Nov; 44(6):1113-29. Vite CH, Head E. PMID: 25441628; PMCID: PMC4254595.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    110. Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. Biochem J. 2014 Oct 15; 463(2):177-89. Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M. PMID: 25242166; PMCID: PMC4686233.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    111. Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome? Alzheimers Res Ther. 2014; 6(5-8):61. Head E, Schmitt FA. PMID: 25478026; PMCID: PMC4255531.
      View in: PubMed   Mentions:    Fields:    
    112. An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radic Biol Med. 2014 Nov; 76:89-95. Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. PMID: 25151119; PMCID: PMC4252833.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    113. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. J Cereb Blood Flow Metab. 2014 Oct; 34(10):1637-45. Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. PMID: 25052558; PMCID: PMC4269722.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    114. Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta. 2014 Jul; 1842(7):1144-53. Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. PMID: 24735980; PMCID: PMC4062876.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    115. Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med. 2014 Jun; 71:270-280. Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. PMID: 24675226; PMCID: PMC4686229.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    116. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Front Pharmacol. 2014; 5:47. Davis PR, Head E. PMID: 24711794; PMCID: PMC3968758.
      View in: PubMed   Mentions: 10  
    117. Frontal white matter integrity in adults with Down syndrome with and without dementia. Neurobiol Aging. 2014 Jul; 35(7):1562-9. Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E. PMID: 24582640; PMCID: PMC3992921.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    118. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. J Alzheimers Dis. 2014; 42(3):767-75. Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. PMID: 24927707; PMCID: PMC4392817.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    119. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. J Alzheimers Dis. 2014; 42(4):1221-7. Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. PMID: 25024306; PMCID: PMC4198456.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    120. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. J Alzheimers Dis. 2014; 39(1):191-210. Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. PMID: 24150111; PMCID: PMC4376359.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    121. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta. 2013 Aug; 1832(8):1249-59. Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. PMID: 23603808; PMCID: PMC3940071.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    122. A canine model of human aging and Alzheimer's disease. Biochim Biophys Acta. 2013 Sep; 1832(9):1384-9. Head E. PMID: 23528711; PMCID: PMC3937962.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    123. Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS One. 2013; 8(3):e59735. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. PMID: 23555764; PMCID: PMC3605408.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    124. Alzheimer's Disease in Down Syndrome. Eur J Neurodegener Dis. 2012 Dec; 1(3):353-364. Head E, Powell D, Gold BT, Schmitt FA. PMID: 25285303; PMCID: PMC4184282.
      View in: PubMed   Mentions: 65  
    125. Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. J Cereb Blood Flow Metab. 2013 Feb; 33(2):205-14. Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. PMID: 23149553; PMCID: PMC3564189.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    126. Aging and down syndrome. Curr Gerontol Geriatr Res. 2012; 2012:412536. Head E, Silverman W, Patterson D, Lott IT. PMID: 22844278; PMCID: PMC3400297.
      View in: PubMed   Mentions: 35  
    127. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Alzheimer's Disease Genetics Consortium (ADGC), Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. PMID: 22722634; PMCID: PMC3398432.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    128. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Curr Gerontol Geriatr Res. 2012; 2012:179318. Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. PMID: 22649448; PMCID: PMC3357506.
      View in: PubMed   Mentions: 5  
    129. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012 Apr 10; 29(6):1054-70. Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. PMID: 22017610; PMCID: PMC3325552.
      View in: PubMed   Mentions: 49     Fields:    
    130. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. J Alzheimers Dis. 2012; 32(4):1029-42. Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. PMID: 22886019; PMCID: PMC4006672.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    131. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Curr Neuropharmacol. 2011 Dec; 9(4):651-61. Martin SB, Dowling AL, Head E. PMID: 22654723; PMCID: PMC3263459.
      View in: PubMed   Mentions: 7     Fields:    
    132. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem. 2012 Jan; 120(1):135-46. Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. PMID: 22004509.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    133. BACE2 expression increases in human neurodegenerative disease. Am J Pathol. 2012 Jan; 180(1):337-50. Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. PMID: 22074738; PMCID: PMC3338345.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    134. Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. BJU Int. 2012 Jun; 109(11):1666-73. Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N'Dow J, Grigor KM, Edinburgh Urological Cancer Group. PMID: 22044434.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    135. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72. Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. PMID: 21876463; PMCID: PMC3339866.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    136. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 22046234; PMCID: PMC3202527.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    137. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta. 2012 Feb; 1822(2):130-8. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. PMID: 22009041; PMCID: PMC3260028.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    138. Antioxidants in the canine model of human aging. Biochim Biophys Acta. 2012 May; 1822(5):685-9. Dowling AL, Head E. PMID: 22005070; PMCID: PMC3291812.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    139. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol. 2012 Aug; 15(7):981-7. Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. PMID: 21767440.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    140. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neurosci Lett. 2011 Aug 26; 501(2):92-5. Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. PMID: 21763754; PMCID: PMC3174091.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    141. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A. 2011 Aug; 155A(8):1939-48. Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. PMID: 21739598; PMCID: PMC3410645.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    142. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 21546126; PMCID: PMC3154439.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    143. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. PMID: 21516511; PMCID: PMC3179861.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    144. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. PMID: 21460841; PMCID: PMC3090745.
      View in: PubMed   Mentions: 1027     Fields:    Translation:Humans
    145. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. J Alzheimers Dis. 2011; 23(3):399-409. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. PMID: 21116050; PMCID: PMC3219221.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    146. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res. 2011 Mar; 63(3):172-80. Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. PMID: 21193043; PMCID: PMC3034810.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    147. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Mol Neurodegener. 2010 Dec 13; 5:57. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. PMID: 21144050; PMCID: PMC3019145.
      View in: PubMed   Mentions: 80     Fields:    
    148. Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Ann N Y Acad Sci. 2010 Oct; 1207:58-70. Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. PMID: 20955427; PMCID: PMC2958685.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    149. Neurobiology of the aging dog. Age (Dordr). 2011 Sep; 33(3):485-96. Head E. PMID: 20845082; PMCID: PMC3168593.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    150. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. PMID: 20838618; PMCID: PMC2935886.
      View in: PubMed   Mentions: 82     Fields:    Translation:Humans
    151. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci. 2010 Jul 21; 30(29):9831-9. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. PMID: 20660265; PMCID: PMC3769160.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    152. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis. 2010 Sep; 39(3):301-10. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. PMID: 20451612; PMCID: PMC2910127.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsPHPublic Health
    153. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012 Mar; 33(3):546-54. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. PMID: 20447733; PMCID: PMC2935515.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    154. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. PMID: 20434811; PMCID: PMC2932860.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    155. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. PMID: 20463402; PMCID: PMC4175722.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    156. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. J Alzheimers Dis. 2010; 20(2):637-46. Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. PMID: 20164551; PMCID: PMC2903832.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    157. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis. 2010; 22(1):135-50. Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. PMID: 20847439.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    158. Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm (Vienna). 2010 Feb; 117(2):227-39. Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ. PMID: 20012109; PMCID: PMC2830004.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    159. Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem. 2010 Jan 08; 285(2):1529-43. Kuhn DE, Nuovo GJ, Terry AV, Martin MM, Malana GE, Sansom SE, Pleister AP, Beck WD, Head E, Feldman DS, Elton TS. PMID: 19897480; PMCID: PMC2801278.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    160. Nutrition, brain aging, and neurodegeneration. J Neurosci. 2009 Oct 14; 29(41):12795-801. Joseph J, Cole G, Head E, Ingram D. PMID: 19828791; PMCID: PMC6665319.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    161. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec; 44(12):752-9. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. PMID: 19735717; PMCID: PMC2787885.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    162. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol. 2009 Nov; 220(1):171-6. Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. PMID: 19703441; PMCID: PMC2761532.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    163. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis. 2009 Sep; 35(3):352-8. Tomic JL, Pensalfini A, Head E, Glabe CG. PMID: 19523517; PMCID: PMC2725199.
      View in: PubMed   Mentions: 165     Fields:    Translation:Humans
    164. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol. 2009 Oct; 118(4):505-17. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. PMID: 19360426; PMCID: PMC2737113.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    165. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. CNS Neurol Disord Drug Targets. 2009 Apr; 8(2):98-113. Vasilevko V, Head E. PMID: 19355931.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    166. APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology. 2009 Mar 03; 72(9):829-34. Berlau DJ, Corrada MM, Head E, Kawas CH. PMID: 19255410; PMCID: PMC2667799.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    167. Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease. Int J Physiol Pathophysiol Pharmacol. 2009 Jan 12; 1(1):48-56. Kumasaka DK, Galvan V, Head E, Rohn TT. PMID: 20411026; PMCID: PMC2856934.
      View in: PubMed   Mentions: 3  
    168. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 2009 Feb 13; 284(7):4230-7. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. PMID: 19098006; PMCID: PMC2640961.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    169. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec; 15(4):685-707. Cotman CW, Head E. PMID: 19096165.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    170. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol. 2008 Nov 10; 511(2):257-70. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. PMID: 18792072; PMCID: PMC4105010.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    171. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15605-10. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. PMID: 18832152; PMCID: PMC2563070.
      View in: PubMed   Mentions: 305     Fields:    Translation:Humans
    172. Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochem Res. 2009 Apr; 34(4):670-8. Head E. PMID: 18683046; PMCID: PMC4392815.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    173. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. J Cell Biochem. 2008 Jul 01; 104(4):1232-43. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Head E, Sharman E, Liu J. PMID: 18260126.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    174. Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Age (Dordr). 2009 Sep; 31(3):211-20. Christie LA, Opii WO, Head E. PMID: 19714491; PMCID: PMC2734239.
      View in: PubMed   Mentions: 4     Fields:    
    175. Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? Int J Clin Exp Pathol. 2009; 2(2):108-18. Rohn TT, Head E. PMID: 19079646; PMCID: PMC2583629.
      View in: PubMed   Mentions: 32     Fields:    
    176. Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. PLoS One. 2008 May 07; 3(5):e2124. Movsesyan N, Ghochikyan A, Mkrtichyan M, Petrushina I, Davtyan H, Olkhanud PB, Head E, Biragyn A, Cribbs DH, Agadjanyan MG. PMID: 18461171; PMCID: PMC2358976.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    177. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J Neurosci. 2008 Apr 02; 28(14):3555-66. Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. PMID: 18385314; PMCID: PMC6671080.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCellsPHPublic Health
    178. Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun. 2008 Jun 06; 370(3):473-7. Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry AV, Gardiner K, Head E, Feldman DS, Elton TS. PMID: 18387358; PMCID: PMC2585520.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    179. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci. 2008 Mar 19; 28(12):3051-9. Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. PMID: 18354008; PMCID: PMC6670712.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    180. Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. Vet Clin North Am Small Anim Pract. 2008 Jan; 38(1):167-78, vi. Head E, Rofina J, Zicker S. PMID: 18249248; PMCID: PMC2390776.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    181. Caspase activation in Alzheimer's disease: early to rise and late to bed. Rev Neurosci. 2008; 19(6):383-93. Rohn TT, Head E. PMID: 19317178.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    182. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci. 2007 Nov 14; 27(46):12721-31. Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG. PMID: 18003852; PMCID: PMC2366938.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    183. Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiol Aging. 2009 Jul; 30(7):1125-34. Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. PMID: 18006193; PMCID: PMC7295175.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    184. Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events. Neuroimage. 2008 Feb 01; 39(3):1324-32. Haier RJ, Head K, Head E, Lott IT. PMID: 18006337; PMCID: PMC2409285.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    185. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. PMID: 17897471; PMCID: PMC2100048.
      View in: PubMed   Mentions: 361     Fields:    
    186. Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Ann N Y Acad Sci. 2007 Oct; 1114:398-406. Head E. PMID: 17717087.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    187. Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Arch Neurol. 2007 Aug; 64(8):1193-6. Berlau DJ, Kahle-Wrobleski K, Head E, Goodus M, Kim R, Kawas C. PMID: 17698712; PMCID: PMC3378248.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    188. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem. 2007 Sep; 88(2):249-59. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. PMID: 17587610; PMCID: PMC2173881.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    189. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. J Alzheimers Dis. 2007 Mar; 11(1):61-76. Head E, Lott IT, Patterson D, Doran E, Haier RJ. PMID: 17361036.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    190. Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res. 2006 Dec; 3(5):521-8. Lott IT, Head E, Doran E, Busciglio J. PMID: 17168651.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    191. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan; 29(1):39-50. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. PMID: 17092609; PMCID: PMC2198929.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    192. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan; 29(1):51-70. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. PMID: 17055614; PMCID: PMC2203613.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    193. Neuroprotective effects of cognitive enrichment. Ageing Res Rev. 2006 Aug; 5(3):354-69. Milgram NW, Siwak-Tapp CT, Araujo J, Head E. PMID: 16949888.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    194. Relapsing polychondritis with features of dementia with Lewy bodies. Acta Neuropathol. 2006 Aug; 112(2):217-25. Head E, Starr A, Kim RC, Parachikova A, Lopez GE, Dick M, Cribbs DH. PMID: 16832629.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    195. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem. 2006 Sep; 86(2):197-204. Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. PMID: 16616528.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    196. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. J Feline Med Surg. 2006 Aug; 8(4):234-42. Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ. PMID: 16603401.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    197. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol. 2006 Mar; 168(3):936-46. Mouser PE, Head E, Ha KH, Rohn TT. PMID: 16507909; PMCID: PMC1606516.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    198. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 Apr 05; 24(15):2824-34. Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. PMID: 16460841.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    199. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 2006 Jan 01; 29(1):234-44. Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. PMID: 16275022.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    200. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. PMID: 16271803.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    201. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005 Sep 01; 227(5):722-8. Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. PMID: 16178393.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    202. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. PMID: 15986225.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    203. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordr). 2005 Mar; 27(1):27-37. Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. PMID: 23598601; PMCID: PMC3456092.
      View in: PubMed   Mentions: 7     Fields:    
    204. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 2005 May; 26(5):749-63. Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. PMID: 15708450.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    205. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. J Neurosci. 2005 Mar 02; 25(9):2295-303. Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. PMID: 15745955; PMCID: PMC6726094.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    206. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):399-406. Tapp PD, Chu Y, Araujo JA, Chiou JY, Head E, Milgram NW, Su MY. PMID: 15795048.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    207. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):443-53. Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. PMID: 15795053.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    208. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):361-9. Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. PMID: 15795044.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    209. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):461-9. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. PMID: 15795055.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    210. A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):389-97. Su MY, Tapp PD, Vu L, Chen YF, Chu Y, Muggenburg B, Chiou JY, Chen C, Wang J, Bracco C, Head E. PMID: 15795047.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    211. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging. 2005 Mar; 26(3):383-9. Lott IT, Head E. PMID: 15639317.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    212. Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach. J Neurochem. 2005 Feb; 92(4):705-17. Thomas SN, Soreghan BA, Nistor M, Sarsoza F, Head E, Yang AJ. PMID: 15686472.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    213. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci. 2004 Nov; 1033:117-31. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. PMID: 15591009.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    214. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004 Sep 22; 24(38):8205-13. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. PMID: 15385603; PMCID: PMC6729694.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    215. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res. 2004 Aug 12; 153(1):199-210. Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. PMID: 15219721.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    216. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004 May; 39(5):753-65. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. PMID: 15130670.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    217. Down syndrome and beta-amyloid deposition. Curr Opin Neurol. 2004 Apr; 17(2):95-100. Head E, Lott IT. PMID: 15021233.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    218. Nutraceuticals, aging, and cognitive dysfunction. Vet Clin North Am Small Anim Pract. 2004 Jan; 34(1):217-28. Head E, Zicker SC. PMID: 15032129.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    219. Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord. 2004; 17(4):360-7. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. PMID: 15178954; PMCID: PMC2637356.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    220. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology. 2003 Dec 23; 61(12):1673-9. Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. PMID: 14694028.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCTClinical Trials
    221. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. Zhao M, Su J, Head E, Cotman CW. PMID: 14678756.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    222. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. Eur J Immunol. 2003 Dec; 33(12):3232-41. Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. PMID: 14635031; PMCID: PMC1524857.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    223. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. PMID: 14570555.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    224. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. Bi X, Head E, Cotman CW, Lynch G. PMID: 12900930.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    225. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. J Neuropathol Exp Neurol. 2003 Sep; 62(9):917-26. Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. PMID: 14533781.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    226. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. PMID: 12931965.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    227. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. PMID: 12702875.
      View in: PubMed   Mentions: 1488     Fields:    Translation:HumansAnimalsCells
    228. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. PMID: 12551965; PMCID: PMC196651.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    229. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. PMID: 12505426.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    230. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
      View in: PubMed   Mentions: 19     Fields:    
    231. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. PMID: 12480733.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    232. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. PMID: 12213643.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    233. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002 Jul; 82(2):375-81. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. PMID: 12124438.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    234. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. PMID: 11854529; PMCID: PMC122369.
      View in: PubMed   Mentions: 169     Fields:    Translation:AnimalsCells
    235. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct; 8(5):792-806. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. PMID: 11592849.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    236. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001 Apr; 8(2):252-65. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. PMID: 11300721.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    237. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol. 2001 Jan; 158(1):189-98. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. PMID: 11141492; PMCID: PMC1850275.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    238. Down syndrome and Alzheimer's disease: a link between development and aging. Ment Retard Dev Disabil Res Rev. 2001; 7(3):172-8. Lott IT, Head E. PMID: 11553933.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    239. Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther. 2001; 2(3):247-60. Head E. PMID: 19746668.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    240. Canine cognition, aging and neuropathology. Introduction. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):671-3. Head E, Cotman CW, Milgram NW. PMID: 11191707.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    241. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):777-86. Head E, Thornton PL, Tong L, Cotman CW. PMID: 11191712.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    242. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Exp Neurol. 2000 May; 163(1):111-22. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. PMID: 10785449.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    243. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000 Jan-Feb; 21(1):89-96. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. PMID: 10794853.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    244. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol. 1999 Oct; 56(10):1233-9. Johnson JK, Head E, Kim R, Starr A, Cotman CW. PMID: 10520939.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    245. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Exp Neurol. 1999 Jun; 157(2):277-88. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. PMID: 10364440.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    246. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging. 1998 Sep-Oct; 19(5):479-85. Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. PMID: 9880050.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    247. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging. 1998 Sep-Oct; 19(5):415-25. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. PMID: 9880044.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    248. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 07; 774(1-2):35-43. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. PMID: 9452189.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    249. Open field activity and human interaction as a function of age and breed in dogs. Physiol Behav. 1997 Nov; 62(5):963-71. Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. PMID: 9333188.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    250. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. PMID: 8661247.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    251. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. PMID: 8744407.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
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