Robert Francis Hunt
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Title(s) | Associate Professor, Anatomy and Neurobiology |
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Address | 1001 Health Sciences Road Irvine CA 92697-3950
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Phone | (949) 824-7079 |
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vCard | Download vCard |
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Biography UCSF | Postdoc | 2015 | Neuroscience | University of Kentucky | PhD | 2010 | Physiology |
Overview Understanding the basic biology of the brain - how it develops and how it functions - remains one of the greatest challenges in science. Our work focuses largely on a group of nerve cells called inhibitory interneurons, the primary source of inhibition in the brain of most animals. We have discovered some of the ways in which disease-linked genes regulate the development and function of these cells and are beginning to learn how they operate at the circuit and behavioral level as well as in disorders of brain development such as epilepsy, intellectual disability and/or autism. To do this, we analyze mice with mutations in genes linked to epilepsy and, more recently, induced pluripotent stem cells (iPSCs) derived from the skin of human patients.
The lab is also designing circuit-based therapies to rewire different brain structures in living animals and reprogram their behavior. Historically, modern medicine has relied on pharmacological approaches to deliver drugs throughout the body. While these chronic drug strategies can work, they are quite crude and often result in unwanted side effects. By focusing on a circuit-level understanding of how the brain generates behavior, we recently discovered a way to stop seizures (and other behavioral problems) in severely epileptic mice. This approach involves grafting new inhibitory interneurons into areas of the brain important for seizure generation. Based on this work, we have an increasing interest in the generation of specific, well-defined cell types for use in cell therapy and continue to explore new avenues for rewiring the nervous system.
Research ORNG Applications Bibliographic
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Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS. eNeuro. 2021 Mar 03.
Das A, Zhu B, Xie Y, Zeng L, Pham AT, Neumann JC, Safrina O, Benavides DR, MacGregor GR, Schutte SS, Hunt RF, O'Dowd DK. PMID: 33658306.
View in: PubMed Mentions: Fields:
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Transplanted interneurons improve memory precision after traumatic brain injury. Nat Commun. 2019 11 14; 10(1):5156.
Zhu B, Eom J, Hunt RF. PMID: 31727894.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory. Neuron. 2018 12 05; 100(5):1180-1193.e6.
Kim YJ, Khoshkhoo S, Frankowski JC, Zhu B, Abbasi S, Lee S, Wu YE, Hunt RF. PMID: 30344048.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Selective vulnerability of hippocampal interneurons to graded traumatic brain injury. Neurobiol Dis. 2019 09; 129:208-216.
Frankowski JC, Kim YJ, Hunt RF. PMID: 30031783.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Irritable No More: Activating Mossy Cells for the Treatment of Epilepsy. Epilepsy Curr. 2018 Jul-Aug; 18(4):251-252.
Kim YJ, Hunt RF. PMID: 30254523.
View in: PubMed Mentions:
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PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus. Sci Rep. 2017 08 15; 7(1):8269.
Dinday MT, Girskis KM, Lee S, Baraban SC, Hunt RF. PMID: 28811646.
View in: PubMed Mentions: 2 Fields:
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Interneuron Transplantation as a Treatment for Epilepsy. Cold Spring Harb Perspect Med. 2015 Dec 01; 5(12).
Hunt RF, Baraban SC. PMID: 26627452.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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NPAS1 represses the generation of specific subtypes of cortical interneurons. Neuron. 2014 Dec 03; 84(5):940-53.
Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, Hunt RF, Lindtner S, Erdman CA, Pieper AA, Hamilton SP, Xu D, Baraban SC, Rubenstein JL. PMID: 25467980.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
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14-3-3e and ? regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014 Sep 03; 34(36):12168-81.
Toyo-oka K, Wachi T, Hunt RF, Baraban SC, Taya S, Ramshaw H, Kaibuchi K, Schwarz QP, Lopez AF, Wynshaw-Boris A. PMID: 25186760.
View in: PubMed Mentions: 33 Fields: Translation: AnimalsCells
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Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014 Apr 16; 82(2):350-64.
Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein JL. PMID: 24742460.
View in: PubMed Mentions: 47 Fields: Translation: HumansAnimalsCells
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Neural circuit mechanisms of post-traumatic epilepsy. Front Cell Neurosci. 2013; 7:89.
Hunt RF, Boychuk JA, Smith BN. PMID: 23785313.
View in: PubMed Mentions:
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GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat Neurosci. 2013 Jun; 16(6):692-7.
Hunt RF, Girskis KM, Rubenstein JL, Alvarez-Buylla A, Baraban SC. PMID: 23644485.
View in: PubMed Mentions: 101 Fields: Translation: AnimalsCells
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The devil is in the details: stem cells for the treatment of epilepsy. Epilepsy Curr. 2012 Nov; 12(6):213-5.
Hunt RF, Baraban SC. PMID: 23447713.
View in: PubMed Mentions:
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LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus. J Neurosci. 2012 Sep 12; 32(37):12862-75.
Hunt RF, Dinday MT, Hindle-Katel W, Baraban SC. PMID: 22973010.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Exp Neurol. 2012 Sep; 237(1):199-206.
Hunt RF, Hortopan GA, Gillespie A, Baraban SC. PMID: 22735490.
View in: PubMed Mentions: 22 Fields: Translation: Animals
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Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains. Epilepsy Res. 2012 Mar; 99(1-2):167-70.
Hunt RF, Haselhorst LA, Schoch KM, Bach EC, Rios-Pilier J, Scheff SW, Saatman KE, Smith BN. PMID: 22047981.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Synaptic reorganization of inhibitory hilar interneuron circuitry after traumatic brain injury in mice. J Neurosci. 2011 May 04; 31(18):6880-90.
Hunt RF, Scheff SW, Smith BN. PMID: 21543618.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
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Regionally localized recurrent excitation in the dentate gyrus of a cortical contusion model of posttraumatic epilepsy. J Neurophysiol. 2010 Mar; 103(3):1490-500.
Hunt RF, Scheff SW, Smith BN. PMID: 20089815.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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Posttraumatic epilepsy after controlled cortical impact injury in mice. Exp Neurol. 2009 Feb; 215(2):243-52.
Hunt RF, Scheff SW, Smith BN. PMID: 19013458.
View in: PubMed Mentions: 64 Fields: Translation: AnimalsCells
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Year | Publications |
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2008 | 1 | 2010 | 1 | 2011 | 2 | 2012 | 3 | 2013 | 2 | 2014 | 3 | 2015 | 1 | 2017 | 1 | 2018 | 3 | 2019 | 1 | 2021 | 1 |
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