Frank M. LaFerla

Title(s)Dean, School of Biological Sciences, School of Biological Sciences Dean's Office
SchoolSchool of Biological Sciences
Address5120 Natural Sciences II
Zot 1450
Irvine CA 92697
Phone(949) 824-5315
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    Collapse Research 
    Collapse Research Activities and Funding
    Deciphering the role of interleukin-18 as a driver of tau pathology in Alzheimer's disease
    NIH R01AG073366Aug 15, 2021 - May 31, 2026
    Role: Principal Investigator
    NF-κB as a driver of neurotoxic astrocytes in Alzheimers disease
    NIH R21AG069081Sep 30, 2020 - Aug 31, 2022
    Role: Principal Investigator
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH P30AG066519Jun 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    UC Irvine AD Translational Center for Disease Model Resources
    NIH U54AG054349Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    The impact of endocytic protein Tom1 on Alzheimer's disease
    NIH R21AG054884Sep 30, 2016 - Apr 30, 2019
    Role: Principal Investigator
    A Neurolucida and Stereo Investigator Imaging System with MicroLucida
    NIH S10OD010420May 15, 2012 - May 14, 2013
    Role: Principal Investigator
    Learning and Memory Impairments in Transgenic AD Models
    NIH R01AG027544Dec 1, 2005 - Jun 30, 2018
    Role: Principal Investigator
    Gene Interactions in a Model of Alzheimer's Disease
    NIH R01AG021982Jul 1, 2003 - May 31, 2014
    Role: Principal Investigator
    Modulating IBM pathology in transgenic mice
    NIH R01AG020335Mar 1, 2002 - Feb 28, 2007
    Role: Principal Investigator
    Regulation of calcium signaling pathways by presenilins
    NIH R01AG017968Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH P50AG016573Apr 15, 2000 - Mar 31, 2020
    Role: Principal Investigator
    TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITIS
    NIH R29AG015409Apr 15, 1998 - Mar 31, 2003
    Role: Principal Investigator
    VIRAL COFACTOR AND SPORADIC ALZHEIMERS DISEASE
    NIH R03AG014864Jul 15, 1997 - Jun 30, 1998
    Role: Principal Investigator
    TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITIS
    NIH R03AG014508Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    Core A: Administrative Core
    NIH P50-16
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. Alzheimers Res Ther. 2024 Apr 04; 16(1):70. Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA. PMID: 38575959; PMCID: PMC10996108.
      View in: PubMed   Mentions:    Fields:    
    2. Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice. Alzheimers Dement. 2024 Apr 04. Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL. PMID: 38572865.
      View in: PubMed   Mentions:    Fields:    
    3. Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2024 Mar 25; 15(1):88. Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. PMID: 38523285; PMCID: PMC10962161.
      View in: PubMed   Mentions:    Fields:    
    4. The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage. Alzheimers Dement. 2024 Mar 20. Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR, Green KN. PMID: 38506634.
      View in: PubMed   Mentions:    Fields:    
    5. BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease. Alzheimers Dement. 2024 Mar 09. Garcia-Agudo LF, Shi Z, Smith IF, Kramár EA, Tran K, Kawauchi S, Wang S, Collins S, Walker A, Shi KX, Neumann J, Liang HY, Da Cunha C, Milinkeviciute G, Morabito S, Miyoshi E, Rezaie N, Gomez-Arboledas A, Arvilla AM, Ghaemi DI, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, Swarup V, MacGregor GR, Green KN. PMID: 38460121.
      View in: PubMed   Mentions:    Fields:    
    6. Genetic diversity promotes resilience in a mouse model of Alzheimer's disease. Alzheimers Dement. 2024 Mar 01. Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR, Green KN. PMID: 38426371.
      View in: PubMed   Mentions:    Fields:    
    7. Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis. Res Sq. 2023 Oct 23. Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA. PMID: 37961253; PMCID: PMC10635349.
      View in: PubMed   Mentions:
    8. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, et al. PMID: 37461624; PMCID: PMC10350126.
      View in: PubMed   Mentions:
    9. A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D. Int J Mol Sci. 2023 Apr 04; 24(7). Terron HM, Maranan DS, Burgard LA, LaFerla FM, Lane S, Leissring MA. PMID: 37047718; PMCID: PMC10095275.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques. Mol Neurodegener. 2023 02 17; 18(1):12. Tran KM, Kawauchi S, Kramár EA, Rezaie N, Liang HY, Sakr JS, Gomez-Arboledas A, Arreola MA, Cunha CD, Phan J, Wang S, Collins S, Walker A, Shi KX, Neumann J, Filimban G, Shi Z, Milinkeviciute G, Javonillo DI, Tran K, Gantuz M, Forner S, Swarup V, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, MacGregor GR, Green KN. PMID: 36803190; PMCID: PMC9938579.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Deletion of MyD88 in astrocytes prevents β-amyloid-induced neuropathology in mice. Glia. 2023 02; 71(2):431-449. Jong Huat T, Onraet T, Camats-Perna J, Newcombe EA, Ngo KC, Sue AN, Mirzaei M, LaFerla FM, Medeiros R. PMID: 36271704; PMCID: PMC9970273.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease. Front Neurosci. 2021; 15:785276. Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM. PMID: 35140584; PMCID: PMC8818877.
      View in: PubMed   Mentions: 37  
    13. Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model. Neurobiol Dis. 2022 01; 162:105562. Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. PMID: 34838667; PMCID: PMC9482454.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    14. SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease. Neurotherapeutics. 2021 10; 18(4):2468-2483. Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC, Sarraf ST, Simmon VF, Baglietto-Vargas D, LaFerla FM. PMID: 34738197; PMCID: PMC8804111.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease. Sci Data. 2021 10 15; 8(1):270. Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM, Green KN. PMID: 34654824; PMCID: PMC8519958.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    16. Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2021 Sep 09; 11(1):18377. Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. PMID: 34504282; PMCID: PMC8429626.
      View in: PubMed   Mentions: 3     Fields:    
    17. Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology. Nat Commun. 2021 04 23; 12(1):2421. Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. PMID: 33893290; PMCID: PMC8065162.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    18. Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches. Neuroscientist. 2022 12; 28(6):572-593. Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. PMID: 33769131.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    19. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis. Sci Rep. 2021 03 23; 11(1):5819. Oka S, Leon J, Sakumi K, Abolhassani N, Sheng Z, Tsuchimoto D, LaFerla FM, Nakabeppu Y. PMID: 33758207; PMCID: PMC7988129.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113. Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. PMID: 33074286; PMCID: PMC7573798.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    21. Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD. Alzheimers Dement (N Y). 2020; 6(1):e12110. Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT, and The MODEL-AD, Consortium. PMID: 33283040; PMCID: PMC7683958.
      View in: PubMed   Mentions: 41  
    22. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13118. Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. PMID: 32087004; PMCID: PMC7059142.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    23. Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):3917-3919. Martini AC, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 32047040; PMCID: PMC7049100.
      View in: PubMed   Mentions:    Fields:    
    24. BrightFocus Alzheimer's Fast Track 2019. Mol Neurodegener. 2019 12 20; 14(1):48. Whitaker KW, LaFerla FM, Steinbusch HWM, Lemere CA, Bovenkamp DE. PMID: 31861987; PMCID: PMC6924007.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 11 04; 9(1):15936. Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. PMID: 31685865; PMCID: PMC6828807.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21198-21206. Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 31570577; PMCID: PMC6800331.
      View in: PubMed   Mentions: 12     Fields:    
    27. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 Sep; 51(9):1423-1424. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, et al. PMID: 31417202; PMCID: PMC7265117.
      View in: PubMed   Mentions: 28     Fields:    
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    105. A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta. 2012 May; 1820(5):553-64. Coskun P, Wyrembak J, Schriner SE, Chen HW, Marciniack C, Laferla F, Wallace DC. PMID: 21871538; PMCID: PMC3270155.
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    106. The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides. PLoS One. 2011; 6(7):e22370. Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, LaFerla FM, Taraglio S, Dotti CG, Di Cunto F. PMID: 21829458; PMCID: PMC3145648.
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    107. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011 Sep; 7(5):521-531.e1. Tang JX, Mardini F, Caltagarone BM, Garrity ST, Li RQ, Bianchi SL, Gomes O, Laferla FM, Eckenhoff RG, Eckenhoff MF. PMID: 21745760; PMCID: PMC3167023.
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    108. BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology. Neurotox Res. 2012 Feb; 21(2):160-74. Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX. PMID: 21725719; PMCID: PMC3227764.
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    109. Olfactory memory is impaired in a triple transgenic model of Alzheimer disease. Behav Brain Res. 2011 Oct 31; 224(2):408-12. Cassano T, Romano A, Macheda T, Colangeli R, Cimmino CS, Petrella A, LaFerla FM, Cuomo V, Gaetani S. PMID: 21741995.
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    110. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011 Jun 29; 31(26):9513-25. Tran HT, LaFerla FM, Holtzman DM, Brody DL. PMID: 21715616; PMCID: PMC3146343.
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    111. Animal models of Alzheimer's disease. Int J Alzheimers Dis. 2010; 2010:606357. Casadesus G, Arendash G, Laferla F, McDonald M. PMID: 21804934; PMCID: PMC3143420.
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    112. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011 Aug; 179(2):980-91. Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. PMID: 21704011; PMCID: PMC3157199.
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    113. The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease. Cell Physiol Biochem. 2011; 27(6):783-94. Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM. PMID: 21691095.
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    114. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem. 2011 Jul 08; 286(27):24264-74. Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. PMID: 21606494; PMCID: PMC3129207.
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    115. Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol. 2011 Jun; 178(6):2811-22. Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM. PMID: 21531375; PMCID: PMC3124234.
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    116. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011 May 09; 495(1):55-9. Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM. PMID: 21419194; PMCID: PMC3099741.
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    117. ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo. Ann Neurol. 2011 May; 69(5):831-44. Green KN, Khashwji H, Estrada T, Laferla FM. PMID: 21416488.
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    118. Proflavine derivatives as fluorescent imaging agents of amyloid deposits. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2203-6. Garin D, Oukhatar F, Mahon AB, Try AC, Dubois-Dauphin M, Laferla FM, Demeunynck M, Sallanon MM, Chierici S. PMID: 21435875.
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    119. Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner. J Neurosci. 2011 Feb 23; 31(8):2781-91. Neely KM, Green KN, LaFerla FM. PMID: 21414900; PMCID: PMC3064964.
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    120. Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer's disease. Ann Biomed Eng. 2011 Apr; 39(4):1349-57. Lin AJ, Koike MA, Green KN, Kim JG, Mazhar A, Rice TB, LaFerla FM, Tromberg BJ. PMID: 21331663; PMCID: PMC3069335.
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    121. Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation. Ann Neurol. 2011 Feb; 69(2):248-56. Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J. PMID: 21387370.
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    122. Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease. J Proteomics. 2011 Apr 01; 74(4):466-79. Chou JL, Shenoy DV, Thomas N, Choudhary PK, Laferla FM, Goodman SR, Breen GA. PMID: 21237293.
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    123. Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. J Alzheimers Dis. 2011; 24(3):421-54. García-Mesa Y, López-Ramos JC, Giménez-Llort L, Revilla S, Guerra R, Gruart A, Laferla FM, Cristòfol R, Delgado-García JM, Sanfeliu C. PMID: 21297257.
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    124. Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17; 5(11):e14015. Parachikova A, Green KN, Hendrix C, LaFerla FM. PMID: 21103342; PMCID: PMC2984445.
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    125. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One. 2010 Nov 16; 5(11):e15477. Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J. PMID: 21103384; PMCID: PMC2982845.
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    126. Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. J Neurosci. 2010 Oct 20; 30(42):13966-76. Piedrahita D, Hernández I, López-Tobón A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gómez JC, Kosik KS, Cardona-Gómez GP. PMID: 20962218; PMCID: PMC3003593.
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    127. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010 Nov; 120(5):605-21. Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I. PMID: 20697724.
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    128. Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 2010 Aug 06; 1347:179-85. Nicholson RM, Kusne Y, Nowak LA, LaFerla FM, Reiman EM, Valla J. PMID: 20677372; PMCID: PMC2974951.
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    129. Pathways linking Abeta and tau pathologies. Biochem Soc Trans. 2010 Aug; 38(4):993-5. LaFerla FM. PMID: 20658991.
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    130. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes. Brain Res. 2010 Aug 12; 1348:149-55. Sterniczuk R, Antle MC, Laferla FM, Dyck RH. PMID: 20558146.
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    131. The role of tau in Alzheimer's disease and related disorders. CNS Neurosci Ther. 2011 Oct; 17(5):514-24. Medeiros R, Baglietto-Vargas D, LaFerla FM. PMID: 20553310; PMCID: PMC4072215.
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    132. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes. Brain Res. 2010 Aug 12; 1348:139-48. Sterniczuk R, Dyck RH, Laferla FM, Antle MC. PMID: 20471965.
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    133. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26; 30(21):7281-9. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. PMID: 20505094; PMCID: PMC3308018.
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    134. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010 Jul; 177(1):300-10. Koike MA, Green KN, Blurton-Jones M, Laferla FM. PMID: 20472896; PMCID: PMC2893673.
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    135. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci. 2010 Apr; 13(4):411-3. Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. PMID: 20305648; PMCID: PMC4072212.
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    136. Alzheimer's disease. N Engl J Med. 2010 Jan 28; 362(4):329-44. Querfurth HW, LaFerla FM. PMID: 20107219.
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    137. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3081-6. Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. PMID: 20133765; PMCID: PMC2840286.
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    138. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One. 2010 Jan 20; 5(1):e8593. Hasegawa T, Mikoda N, Kitazawa M, LaFerla FM. PMID: 20098691; PMCID: PMC2808336.
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    139. Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis. 2010; 19(3):915-25. Chakravarthy B, Gaudet C, Ménard M, Atkinson T, Brown L, Laferla FM, Armato U, Whitfield J. PMID: 20157247.
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    140. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010; 21(2):527-42. Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN. PMID: 20555131; PMCID: PMC4085054.
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    141. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010 Feb; 176(2):870-80. Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM. PMID: 20042680; PMCID: PMC2808092.
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    142. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009 Dec 28; 187(7):1083-99. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. PMID: 20026656; PMCID: PMC2806289.
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    143. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010 May; 30(4):577-90. Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM. PMID: 19943189.
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    144. Inhaled anesthetic potency in aged Alzheimer mice. Anesth Analg. 2010 Feb 01; 110(2):427-30. Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB. PMID: 19820240; PMCID: PMC4899815.
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    145. Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience. 2009 Dec 15; 164(3):1334-46. Robertson RT, Baratta J, Yu J, LaFerla FM. PMID: 19772895; PMCID: PMC2784206.
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    146. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem. 2009 Oct 23; 284(43):29427-36. Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. PMID: 19710014; PMCID: PMC2785575.
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    147. Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. Biol Psychiatry. 2010 Mar 15; 67(6):513-21. España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA. PMID: 19664757.
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    148. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. PMID: 19633196; PMCID: PMC2715325.
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    149. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15; 183(2):1375-83. Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM, Taylor SM, Woodruff TM, Tenner AJ. PMID: 19561098; PMCID: PMC4067320.
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    150. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. Neurochem Int. 2009 Dec; 55(7):476-82. Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. PMID: 19442696.
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    151. Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J Neurosci. 2009 May 13; 29(19):6132-41. Kitazawa M, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19439591; PMCID: PMC3049190.
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    152. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. J Neurosci Res. 2009 May 01; 87(6):1462-73. Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. PMID: 19021293; PMCID: PMC2832596.
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    153. M1 agonists as a potential disease-modifying therapy for Alzheimer's disease. Curr Alzheimer Res. 2009 Apr; 6(2):112-7. Caccamo A, Fisher A, LaFerla FM. PMID: 19355845.
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    154. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009 Apr; 34(1):163-77. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. PMID: 19320056; PMCID: PMC2948857.
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    155. Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease. Neuropharmacology. 2009 Mar; 56(4):808-13. Bourasset F, Ouellet M, Tremblay C, Julien C, Do TM, Oddo S, LaFerla F, Calon F. PMID: 19705573.
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    156. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 2009 Mar; 108(6):1550-60. Kitazawa M, Cheng D, Laferla FM. PMID: 19183260; PMCID: PMC4096128.
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    157. Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canines. J Alzheimers Dis. 2009; 16(2):315-23. Nuntagij P, Oddo S, LaFerla FM, Kotchabhakdi N, Ottersen OP, Torp R. PMID: 19221421.
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    158. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. J Alzheimers Dis. 2009; 16(3):541-9. Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. PMID: 19276549.
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    159. Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle. Neurobiol Aging. 2010 Dec; 31(12):2080-90. Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW. PMID: 19108934; PMCID: PMC2901770.
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    160. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci. 2008 Nov 19; 28(47):12163-75. Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19020010; PMCID: PMC6671718.
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    161. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008 Nov 05; 28(45):11500-10. Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. PMID: 18987186; PMCID: PMC2617713.
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    162. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. PMID: 18974297; PMCID: PMC2626388.
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    163. Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem. 2009 Mar 06; 284(10):6033-7. Morrissette DA, Parachikova A, Green KN, LaFerla FM. PMID: 18948253.
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    164. Validation of a 2-day water maze protocol in mice. Behav Brain Res. 2009 Jan 23; 196(2):220-7. Gulinello M, Gertner M, Mendoza G, Schoenfeld BP, Oddo S, LaFerla F, Choi CH, McBride SM, Faber DS. PMID: 18831990; PMCID: PMC4303046.
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    165. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS One. 2008 Aug 13; 3(8):e2935. Rodríguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A. PMID: 18698410; PMCID: PMC2492828.
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    166. Linking calcium to Abeta and Alzheimer's disease. Neuron. 2008 Jul 31; 59(2):190-4. Green KN, LaFerla FM. PMID: 18667147.
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    167. Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology. Brain Pathol. 2009 Jul; 19(3):421-30. Oddo S, Caccamo A, Cheng D, LaFerla FM. PMID: 18657136; PMCID: PMC4072242.
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    168. Experience-dependent regulation of vesicular zinc in male and female 3xTg-AD mice. Neurobiol Aging. 2010 Apr; 31(4):605-13. Nakashima AS, Oddo S, Laferla FM, Dyck RH. PMID: 18603329.
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    169. Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta. Ann Neurol. 2008 Jul; 64(1):15-24. Kitazawa M, Trinh DN, LaFerla FM. PMID: 18318434.
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    170. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18591429; PMCID: PMC2442205.
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    171. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res. 2008 Jun 24; 1216:92-103. Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y. PMID: 18486110.
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    172. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 01; 1207:225-36. McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. PMID: 18374906; PMCID: PMC2587244.
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    173. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 2007 Nov 28; 27(48):13357-65. Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ. PMID: 18045930; PMCID: PMC6673397.
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    174. Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. J Neurochem. 2008 Apr; 105(1):262-71. Lopez JR, Lyckman A, Oddo S, Laferla FM, Querfurth HW, Shtifman A. PMID: 18021291.
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    175. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. PMID: 17978032; PMCID: PMC6673368.
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    176. Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration. Eur J Neurosci. 2007 Nov; 26(9):2458-68. Takata K, Hirata-Fukae C, Becker AG, Chishiro S, Gray AJ, Nishitomi K, Franz AH, Sakaguchi G, Kato A, Mattson MP, Laferla FM, Aisen PS, Kitamura Y, Matsuoka Y. PMID: 17970733.
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    177. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. PMID: 17953662.
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    178. Age-related accumulation of Reelin in amyloid-like deposits. Neurobiol Aging. 2009 May; 30(5):697-716. Knuesel I, Nyffeler M, Mormède C, Muhia M, Meyer U, Pietropaolo S, Yee BK, Pryce CR, LaFerla FM, Marighetto A, Feldon J. PMID: 17904250.
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    179. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem. 2007 Nov; 103(3):1132-44. Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C. PMID: 17683481.
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    180. Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci. 2007 Jul; 8(7):499-509. LaFerla FM, Green KN, Oddo S. PMID: 17551515.
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    181. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis. 2007 Oct; 28(1):76-82. Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, McGaugh JL, LaFerla FM. PMID: 17659878; PMCID: PMC2756084.
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    182. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging. 2008 Nov; 29(11):1607-18. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. PMID: 17544172; PMCID: PMC2664168.
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    183. Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007 May; 170(5):1669-75. Caccamo A, Oddo S, Tran LX, LaFerla FM. PMID: 17456772; PMCID: PMC1854961.
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    184. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007 Aug; 102(4):1053-63. Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM. PMID: 17472708.
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    185. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci. 2007 Apr 18; 27(16):4385-95. Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM. PMID: 17442823; PMCID: PMC6672302.
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    186. Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Ann N Y Acad Sci. 2007 Feb; 1097:265-77. Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F. PMID: 17413028.
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    187. Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice. J Neurosci. 2007 Jan 24; 27(4):751-61. Billings LM, Green KN, McGaugh JL, LaFerla FM. PMID: 17251414; PMCID: PMC6672918.
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    188. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2007 Apr; 26(1):212-20. Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP. PMID: 17306982.
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    189. Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci. 2007; 31(2):165-70. Matsuoka Y, Gray AJ, Hirata-Fukae C, Minami SS, Waterhouse EG, Mattson MP, LaFerla FM, Gozes I, Aisen PS. PMID: 17478890.
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    190. Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models. Subcell Biochem. 2007; 45:507-21. Green KN, Smith IF, Laferla FM. PMID: 18193650.
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    191. Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci. 2006 Dec 20; 26(51):13384-9. Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ. PMID: 17182789; PMCID: PMC6674990.
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    192. Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res. 2006 Dec; 3(5):437-48. Blurton-Jones M, Laferla FM. PMID: 17168643.
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    193. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006 Dec 22; 281(51):39413-23. Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM. PMID: 17056594.
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    194. Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid. Neurosci Biobehav Rev. 2007; 31(1):125-47. Giménez-Llort L, Blázquez G, Cañete T, Johansson B, Oddo S, Tobeña A, LaFerla FM, Fernández-Teruel A. PMID: 17055579.
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    195. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006 Aug 30; 26(35):9047-56. Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM. PMID: 16943563; PMCID: PMC6675335.
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    196. Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB J. 2006 Oct; 20(12):2165-7. Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW. PMID: 16940437.
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    197. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci. 2006 Jun 14; 26(24):6533-42. Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. PMID: 16775141; PMCID: PMC6674046.
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    198. Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol. 2006 Jun; 168(6):1986-97. Kitazawa M, Green KN, Caccamo A, LaFerla FM. PMID: 16723713; PMCID: PMC1606633.
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    199. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci. 2006 May 10; 26(19):5180-9. Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. PMID: 16687509; PMCID: PMC6674246.
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    200. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 02; 49(5):671-82. Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. PMID: 16504943.
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    201. The role of nicotinic acetylcholine receptors in Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):172-9. Oddo S, LaFerla FM. PMID: 16448808.
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    202. A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol. 2006 Jan; 168(1):184-94. Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM. PMID: 16400022; PMCID: PMC1592652.
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    203. Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad. Neuron. 2005 Dec 08; 48(5):711-2. LaFerla FM, Kitazawa M. PMID: 16337907.
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    204. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006 Jan 20; 281(3):1599-604. Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. PMID: 16282321.
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    205. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23. Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. PMID: 16232318; PMCID: PMC1276812.
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    206. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Sep 28; 25(39):8843-53. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. PMID: 16192374; PMCID: PMC6725603.
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    207. Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem. 2005 Sep; 94(6):1711-8. Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM. PMID: 16156741.
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    208. Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium. 2005 Sep-Oct; 38(3-4):427-37. Smith IF, Green KN, LaFerla FM. PMID: 16125228.
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    209. An array of genes implicated in Alzheimer's disease. Neurobiol Aging. 2006 Aug; 27(8):1078-80. LaFerla FM. PMID: 16112251.
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    210. Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model. Neurobiol Aging. 2006 Mar; 27(3):423-32. Sugarman MC, Kitazawa M, Baker M, Caiozzo VJ, Querfurth HW, LaFerla FM. PMID: 15950323.
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    211. Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May; 26(5):645-54. Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. PMID: 15708439.
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    212. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol Med. 2005 Apr; 11(4):170-6. LaFerla FM, Oddo S. PMID: 15823755.
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    213. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 03; 45(5):675-88. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. PMID: 15748844.
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    214. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):3046-51. Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, LaFerla FM. PMID: 15705720; PMCID: PMC549455.
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    215. Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann N Y Acad Sci. 2004 Dec; 1035:85-103. Kitazawa M, Yamasaki TR, LaFerla FM. PMID: 15681802.
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    216. Amyloid beta-peptide: the inside story. Curr Alzheimer Res. 2004 Nov; 1(4):231-9. Tseng BP, Kitazawa M, LaFerla FM. PMID: 15975052.
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    217. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1145-52. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PMID: 15336962.
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    218. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron. 2004 Aug 05; 43(3):321-32. Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. PMID: 15294141.
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    219. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619; PMCID: PMC437967.
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    220. Live discussion: how the other half lives - or the what, how, and where, of the AbetaPP intracellular domain. J Alzheimers Dis. 2004 Apr; 6(2):193-9. Bishop G, Coleman P, Crutcher K, David D, Kinoshita J, LaFerla F, Leissring M, Shepherd J, Therianos S, Wang R, Wilson A, Zhu M. PMID: 15171221.
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    221. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004 Feb; 113(4):582-90. Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. PMID: 14966567; PMCID: PMC338266.
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    222. Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci. 2004 Jan 14; 24(2):508-13. Stutzmann GE, Caccamo A, LaFerla FM, Parker I. PMID: 14724250; PMCID: PMC6729995.
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    223. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003 Dec; 24(8):1063-70. Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. PMID: 14643377.
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    224. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PMID: 12895417.
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    225. Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. J Neurosci. 2003 Feb 01; 23(3):758-65. Stutzmann GE, LaFerla FM, Parker I. PMID: 12574404; PMCID: PMC6741910.
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    226. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4697-702. Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. PMID: 11917117; PMCID: PMC123710.
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    227. Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling. Nat Biotechnol. 2001 Jul; 19(7):645-9. Marchant JS, Stutzmann GE, Leissring MA, LaFerla FM, Parker I. PMID: 11433276.
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    228. Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling. Neurobiol Dis. 2001 Jun; 8(3):469-78. Leissring MA, LaFerla FM, Callamaras N, Parker I. PMID: 11442355.
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    229. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8590-3. Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM. PMID: 10900016; PMCID: PMC26992.
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    230. Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. Biochemistry. 2000 May 23; 39(20):5988-94. Cribbs DH, Azizeh BY, Cotman CW, LaFerla FM. PMID: 10821670.
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    231. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol. 2000 May 15; 149(4):793-8. Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. PMID: 10811821; PMCID: PMC2174559.
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    232. Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2000 May; 23(5):222-9. Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD. PMID: 10782128.
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    233. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J Biol Chem. 1999 Nov 12; 274(46):32535-8. Leissring MA, Parker I, LaFerla FM. PMID: 10551803.
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    234. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999 Mar; 72(3):1061-8. Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. PMID: 10037477.
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    235. Herpes simplex virus infections and Alzheimer's disease. Implications for drug treatment and immunotherapy. Drugs Aging. 1998 Sep; 13(3):193-8. Leissring MA, Sugarman MC, LaFerla FM. PMID: 9789723.
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    236. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest. 1997 Jul 15; 100(2):310-20. LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G. PMID: 9218507; PMCID: PMC508193.
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    237. Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Exp Neurol. 1997 Jan; 143(1):37-44. Weber LL, Leissring MA, Yang AJ, Glabe CG, Cribbs DH, LaFerla FM. PMID: 9000444.
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    238. Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest. 1996 Oct 01; 98(7):1626-32. LaFerla FM, Hall CK, Ngo L, Jay G. PMID: 8833912; PMCID: PMC507596.
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    239. Injury induces presenilin-1 gene expression in mouse brain. Neuroreport. 1996 Jul 29; 7(11):1773-6. Cribbs DH, Chen LS, Cotman CW, LaFerla FM. PMID: 8905662.
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    240. Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. Am J Pathol. 1996 Jun; 148(6):1797-806. Cribbs DH, Chen LS, Bende SM, LaFerla FM. PMID: 8669467; PMCID: PMC1861636.
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    241. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet. 1995 Jan; 9(1):21-30. LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G. PMID: 7704018.
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