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The impact of astrocytic NF-κB on healthy and Alzheimer's disease brains. Sci Rep. 2024 06 21; 14(1):14305.
Jong Huat T, Camats-Perna J, Newcombe EA, Onraet T, Campbell D, Sucic JT, Martini A, Forner S, Mirzaei M, Poon W, LaFerla FM, Medeiros R. PMID: 38906984; PMCID: PMC11192733.
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1 Fields:
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HumansAnimalsCells
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APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology. bioRxiv. 2024 Jun 04.
Tran KM, Kwang N, Gomez-Arboledas A, Kawauchi S, Mar C, Chao D, Da Cunha C, Wang S, Collins S, Walker A, Shi KX, Alcantara JA, Neumann J, Tenner AJ, LaFerla FM, Hohsfield LA, Swarup V, MacGregor GR, Green KN. PMID: 38895362; PMCID: PMC11185750.
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Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis. Alzheimers Res Ther. 2024 04 04; 16(1):70.
Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA. PMID: 38575959; PMCID: PMC10996108.
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1 Fields:
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HumansAnimals
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Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice. Alzheimers Dement. 2024 07; 20(7):4935-4950.
Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL. PMID: 38572865; PMCID: PMC11247698.
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2 Fields:
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HumansAnimals
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Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2024 Mar 25; 15(1):88.
Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. PMID: 38523285; PMCID: PMC10962161.
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The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage. Alzheimers Dement. 2024 07; 20(7):4914-4934.
Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR, Green KN. PMID: 38506634; PMCID: PMC11247689.
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1 Fields:
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HumansAnimalsCells
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BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease. Alzheimers Dement. 2024 04; 20(4):2922-2942.
Garcia-Agudo LF, Shi Z, Smith IF, Kramár EA, Tran K, Kawauchi S, Wang S, Collins S, Walker A, Shi KX, Neumann J, Liang HY, Da Cunha C, Milinkeviciute G, Morabito S, Miyoshi E, Rezaie N, Gomez-Arboledas A, Arvilla AM, Ghaemi DI, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, Swarup V, MacGregor GR, Green KN. PMID: 38460121; PMCID: PMC11032570.
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1 Fields:
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HumansAnimalsCells
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Genetic diversity promotes resilience in a mouse model of Alzheimer's disease. Alzheimers Dement. 2024 04; 20(4):2794-2816.
Soni N, Hohsfield LA, Tran KM, Kawauchi S, Walker A, Javonillo D, Phan J, Matheos D, Da Cunha C, Uyar A, Milinkeviciute G, Gomez-Arboledas A, Tran K, Kaczorowski CC, Wood MA, Tenner AJ, LaFerla FM, Carter GW, Mortazavi A, Swarup V, MacGregor GR, Green KN. PMID: 38426371; PMCID: PMC11032575.
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2 Fields:
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HumansAnimalsCells
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Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis. Res Sq. 2023 Oct 23.
Terron HM, Parikh SJ, Abdul-Hay SO, Sahara T, Kang D, Dickson DW, Saftig P, LaFerla FM, Lane S, Leissring MA. PMID: 37961253; PMCID: PMC10635349.
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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, et al. PMID: 37461624; PMCID: PMC10350126.
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2
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A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D. Int J Mol Sci. 2023 Apr 04; 24(7).
Terron HM, Maranan DS, Burgard LA, LaFerla FM, Lane S, Leissring MA. PMID: 37047718; PMCID: PMC10095275.
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1 Fields:
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AnimalsCells
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A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques. Mol Neurodegener. 2023 02 17; 18(1):12.
Tran KM, Kawauchi S, Kramár EA, Rezaie N, Liang HY, Sakr JS, Gomez-Arboledas A, Arreola MA, Cunha CD, Phan J, Wang S, Collins S, Walker A, Shi KX, Neumann J, Filimban G, Shi Z, Milinkeviciute G, Javonillo DI, Tran K, Gantuz M, Forner S, Swarup V, Tenner AJ, LaFerla FM, Wood MA, Mortazavi A, MacGregor GR, Green KN. PMID: 36803190; PMCID: PMC9938579.
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16 Fields:
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AnimalsCells
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Deletion of MyD88 in astrocytes prevents β-amyloid-induced neuropathology in mice. Glia. 2023 02; 71(2):431-449.
Jong Huat T, Onraet T, Camats-Perna J, Newcombe EA, Ngo KC, Sue AN, Mirzaei M, LaFerla FM, Medeiros R. PMID: 36271704; PMCID: PMC9970273.
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3 Fields:
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HumansAnimalsCells
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Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease. Front Neurosci. 2021; 15:785276.
Javonillo DI, Tran KM, Phan J, Hingco E, Kramár EA, da Cunha C, Forner S, Kawauchi S, Milinkeviciute G, Gomez-Arboledas A, Neumann J, Banh CE, Huynh M, Matheos DP, Rezaie N, Alcantara JA, Mortazavi A, Wood MA, Tenner AJ, MacGregor GR, Green KN, LaFerla FM. PMID: 35140584; PMCID: PMC8818877.
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56
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Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model. Neurobiol Dis. 2022 01; 162:105562.
Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. PMID: 34838667; PMCID: PMC9482454.
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11 Fields:
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Animals
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SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease. Neurotherapeutics. 2021 10; 18(4):2468-2483.
Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC, Sarraf ST, Simmon VF, Baglietto-Vargas D, LaFerla FM. PMID: 34738197; PMCID: PMC8804111.
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4 Fields:
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Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease. Sci Data. 2021 10 15; 8(1):270.
Forner S, Kawauchi S, Balderrama-Gutierrez G, Kramár EA, Matheos DP, Phan J, Javonillo DI, Tran KM, Hingco E, da Cunha C, Rezaie N, Alcantara JA, Baglietto-Vargas D, Jansen C, Neumann J, Wood MA, MacGregor GR, Mortazavi A, Tenner AJ, LaFerla FM, Green KN. PMID: 34654824; PMCID: PMC8519958.
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118 Fields:
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Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2021 Sep 09; 11(1):18377.
Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. PMID: 34504282; PMCID: PMC8429626.
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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology. Nat Commun. 2021 04 23; 12(1):2421.
Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. PMID: 33893290; PMCID: PMC8065162.
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40 Fields:
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Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches. Neuroscientist. 2022 12; 28(6):572-593.
Trujillo-Estrada L, Sanchez-Mejias E, Sanchez-Varo R, Garcia-Leon JA, Nuñez-Diaz C, Davila JC, Vitorica J, LaFerla FM, Moreno-Gonzalez I, Gutierrez A, Baglietto-Vargas D. PMID: 33769131.
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8 Fields:
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HumansAnimals
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MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis. Sci Rep. 2021 03 23; 11(1):5819.
Oka S, Leon J, Sakumi K, Abolhassani N, Sheng Z, Tsuchimoto D, LaFerla FM, Nakabeppu Y. PMID: 33758207; PMCID: PMC7988129.
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17 Fields:
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Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113.
Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. PMID: 33074286; PMCID: PMC7573798.
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115 Fields:
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Humans
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Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD. Alzheimers Dement (N Y). 2020; 6(1):e12110.
Oblak AL, Forner S, Territo PR, Sasner M, Carter GW, Howell GR, Sukoff-Rizzo SJ, Logsdon BA, Mangravite LM, Mortazavi A, Baglietto-Vargas D, Green KN, MacGregor GR, Wood MA, Tenner AJ, LaFerla FM, Lamb BT, and The MODEL-AD, Consortium. PMID: 33283040; PMCID: PMC7683958.
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miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13118.
Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. PMID: 32087004; PMCID: PMC7059142.
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29 Fields:
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AnimalsCells
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Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):3917-3919.
Martini AC, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 32047040; PMCID: PMC7049100.
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BrightFocus Alzheimer's Fast Track 2019. Mol Neurodegener. 2019 12 20; 14(1):48.
Whitaker KW, LaFerla FM, Steinbusch HWM, Lemere CA, Bovenkamp DE. PMID: 31861987; PMCID: PMC6924007.
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1 Fields:
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Humans
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Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 11 04; 9(1):15936.
Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. PMID: 31685865; PMCID: PMC6828807.
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8 Fields:
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AnimalsCells
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Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21198-21206.
Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 31570577; PMCID: PMC6800331.
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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 Sep; 51(9):1423-1424.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, et al. PMID: 31417202; PMCID: PMC7265117.
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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, et al. PMID: 30820047; PMCID: PMC6463297.
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1286 Fields:
Translation:
Humans
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Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. Aging Cell. 2019 06; 18(3):e12919.
Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM. PMID: 30809950; PMCID: PMC6516168.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease. Sci Rep. 2019 02 04; 9(1):1311.
Stimmell AC, Baglietto-Vargas D, Moseley SC, Lapointe V, Thompson LM, LaFerla FM, McNaughton BL, Wilber AA. PMID: 30718609; PMCID: PMC6361963.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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Astrocytes: From the Physiology to the Disease. Curr Alzheimer Res. 2019; 16(8):675-698.
Trujillo-Estrada L, Gomez-Arboledas A, Forner S, Martini AC, Gutierrez A, Baglietto-Vargas D, LaFerla FM. PMID: 31470787.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease. Mol Cell Neurosci. 2018 10; 92:67-81.
Frontiñán-Rubio J, Sancho-Bielsa FJ, Peinado JR, LaFerla FM, Giménez-Llort L, Durán-Prado M, Alcain FJ. PMID: 29953929.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 08; 17(4):e12791.
Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. PMID: 29877034; PMCID: PMC6052400.
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PubMed Mentions:
36 Fields:
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AnimalsCells
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Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease. Mol Nutr Food Res. 2018 06; 62(12):e1800240.
Lee S, Choi BR, Kim J, LaFerla FM, Park JHY, Han JS, Lee KW, Kim J. PMID: 29714053.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Sci Rep. 2018 04 24; 8(1):6431.
Van der Jeugd A, Parra-Damas A, Baeta-Corral R, Soto-Faguás CM, Ahmed T, LaFerla FM, Giménez-Llort L, D'Hooge R, Saura CA. PMID: 29691439; PMCID: PMC5915484.
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PubMed Mentions:
22 Fields:
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HumansAnimalsCells
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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Mol Neurodegener. 2018 03 01; 13(1):11.
Sosna J, Philipp S, Albay R, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. PMID: 29490706; PMCID: PMC5831225.
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PubMed Mentions:
147 Fields:
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AnimalsCells
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Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease. J Alzheimers Dis. 2018; 64(s1):S365-S378.
Martini AC, Forner S, Trujillo-Estrada L, Baglietto-Vargas D, LaFerla FM. PMID: 29504540.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2017 12 19; 7(1):17762.
Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. PMID: 29259249; PMCID: PMC5736730.
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PubMed Mentions:
85 Fields:
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HumansAnimals
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Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports. 2018 01 09; 10(1):58-72.
Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. PMID: 29233555; PMCID: PMC5768890.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384.
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, et al. PMID: 28714976; PMCID: PMC5669039.
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PubMed Mentions:
476 Fields:
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HumansCells
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Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony. Trends Neurosci. 2017 06; 40(6):347-357.
Forner S, Baglietto-Vargas D, Martini AC, Trujillo-Estrada L, LaFerla FM. PMID: 28494972.
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PubMed Mentions:
179 Fields:
Translation:
HumansAnimalsCells
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Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. Mol Nutr Food Res. 2017 02; 61(2).
Kim J, Lee S, Choi BR, Yang H, Hwang Y, Park JH, LaFerla FM, Han JS, Lee KW, Kim J. PMID: 27735126.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 11 29; 6:37889.
Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. PMID: 27897204; PMCID: PMC5126576.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease. Neuroscience. 2016 08 04; 329:284-93.
Manuel I, Lombardero L, LaFerla FM, Giménez-Llort L, Rodríguez-Puertas R. PMID: 27223629.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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Diabetes and Alzheimer's disease crosstalk. Neurosci Biobehav Rev. 2016 May; 64:272-87.
Baglietto-Vargas D, Shi J, Yaeger DM, Ager R, LaFerla FM. PMID: 26969101.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimals
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AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease. Neurodegener Dis. 2016; 16(1-2):95-110.
Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R. PMID: 26606130; PMCID: PMC4803577.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Accelerating stem cell trials for Alzheimer's disease. Lancet Neurol. 2016 02; 15(2):219-230.
Hunsberger JG, Rao M, Kurtzberg J, Bulte JWM, Atala A, LaFerla FM, Greely HT, Sawa A, Gandy S, Schneider LS, Doraiswamy PM. PMID: 26704439.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5078-87.
Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J, Cotman CW. PMID: 26305968; PMCID: PMC4568670.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015 Sep; 134(5):915-26.
Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. PMID: 26077803; PMCID: PMC4792118.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model. Brain Res Bull. 2015 Aug; 117:10-5.
Martinez-Coria H, Yeung ST, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM. PMID: 26162480.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model. J Neurochem. 2015 Mar; 132(5):609-18.
Garin D, Virgone-Carlotta A, Gözel B, Oukhatar F, Perret P, Marti-Battle D, Touret M, Millet P, Dubois-Dauphin M, Meyronet D, Streichenberger N, Laferla FM, Demeunynck M, Chierici S, Sallanon Moulin M, Ghezzi C. PMID: 25258048.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015 Feb; 7(2):190-210.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. PMID: 25617315; PMCID: PMC4328648.
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PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
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Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16.
Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812; PMCID: PMC4324097.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. 2015 Jul; 25(7):813-26.
Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. PMID: 25530343; PMCID: PMC4722865.
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PubMed Mentions:
97 Fields:
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HumansAnimalsCells
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Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842; PMCID: PMC4314944.
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PubMed Mentions:
102 Fields:
Translation:
Humans
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Neural HO-1/sterol interactions in vivo: implications for Alzheimer's disease. Neuroscience. 2014 Nov 07; 280:40-9.
Hascalovici JR, Song W, Liberman A, Vaya J, Khatib S, Holcroft C, Laferla F, Schipper HM. PMID: 25218961.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model. PLoS One. 2014; 9(9):e106009.
Myczek K, Yeung ST, Castello N, Baglietto-Vargas D, LaFerla FM. PMID: 25184527; PMCID: PMC4153578.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2014 Nov; 71:110-30.
Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, Iqbal K. PMID: 25046994.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Optical imaging in an Alzheimer's mouse model reveals amyloid-β-dependent vascular impairment. Neurophotonics. 2014 Jul; 1(1):011005.
Lin AJ, Liu G, Castello NA, Yeh JJ, Rahimian R, Lee G, Tsay V, Durkin AJ, Choi B, LaFerla FM, Chen Z, Green KN, Tromberg BJ. PMID: 25133200; PMCID: PMC4132842.
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PubMed Mentions:
24
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p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neurosci Lett. 2014 Jul 11; 575:96-100.
Walls KC, Ager RR, Vasilevko V, Cheng D, Medeiros R, LaFerla FM. PMID: 24887583; PMCID: PMC4437620.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2014 Apr 16; 5(2):46.
Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. PMID: 25022790; PMCID: PMC4055090.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS One. 2014; 9(3):e91453.
Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN, LaFerla FM. PMID: 24614170; PMCID: PMC3948846.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014 Apr; 64:107-17.
Chabrier MA, Cheng D, Castello NA, Green KN, LaFerla FM. PMID: 24440055; PMCID: PMC4072239.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014 Mar; 184(3):819-26.
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM. PMID: 24412516; PMCID: PMC3936327.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2014; 40(3):701-12.
Bedse G, Romano A, Cianci S, Lavecchia AM, Lorenzo P, Elphick MR, Laferla FM, Vendemiale G, Grillo C, Altieri F, Cassano T, Gaetani S. PMID: 24496074.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J Alzheimers Dis. 2014; 42(4):1229-38.
Rodriguez-Ortiz CJ, Baglietto-Vargas D, Martinez-Coria H, LaFerla FM, Kitazawa M. PMID: 25024332; PMCID: PMC7294908.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain. Neuroscience. 2014 Feb 14; 259:214-22.
Yeung ST, Myczek K, Kang AP, Chabrier MA, Baglietto-Vargas D, Laferla FM. PMID: 24316470; PMCID: PMC4438704.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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In vivo optical signatures of neuronal death in a mouse model of Alzheimer's disease. Lasers Surg Med. 2014 Jan; 46(1):27-33.
Lin AJ, Castello NA, Lee G, Green KN, Durkin AJ, Choi B, LaFerla F, Tromberg BJ. PMID: 24284732; PMCID: PMC4001800.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014 Feb; 184(2):520-9.
Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. PMID: 24269557.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014 Feb; 62:407-15.
Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. PMID: 24176788.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice. J Neurochem. 2013 Aug; 126(4):473-82.
Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG. PMID: 23672786; PMCID: PMC4105004.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCellsPHPublic Health
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Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15.
Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. PMID: 23747512; PMCID: PMC3730785.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study. Cereb Cortex. 2014 Sep; 24(9):2476-88.
Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y. PMID: 23595620; PMCID: PMC4128707.
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PubMed Mentions:
145 Fields:
Translation:
HumansAnimals
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Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May; 182(5):1780-9.
Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM. PMID: 23506847; PMCID: PMC3644736.
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PubMed Mentions:
82 Fields:
Translation:
AnimalsCells
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Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci. 2013 Mar 13; 33(11):5053-64.
Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, LaFerla FM, Olschowka JA, O'Banion MK. PMID: 23486975; PMCID: PMC3637949.
View in:
PubMed Mentions:
196 Fields:
Translation:
HumansAnimalsCells
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The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice. Am J Pathol. 2013 May; 182(5):1740-9.
Passos GF, Medeiros R, Cheng D, Vasilevko V, Laferla FM, Cribbs DH. PMID: 23470163; PMCID: PMC3644719.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013 Sep 01; 74(5):357-66.
Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN. PMID: 23312564; PMCID: PMC3633722.
View in:
PubMed Mentions:
47 Fields:
Translation:
Animals
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Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. Curr Alzheimer Res. 2013 Jan; 10(1):11-20.
Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T, Murakami K, Irie K, Kinoshita N, LaFerla FM, Kiyohara Y, Iwaki T, Kira J. PMID: 22950910.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Elucidating the triggers, progression, and effects of Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S195-210.
Medeiros R, Chabrier MA, LaFerla FM. PMID: 22635105.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease. PLoS One. 2012; 7(12):e51432.
Chen Y, Tian Z, Liang Z, Sun S, Dai CL, Lee MH, LaFerla FM, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. PMID: 23236499; PMCID: PMC3517562.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Soluble aβ promotes wild-type tau pathology in vivo. J Neurosci. 2012 Nov 28; 32(48):17345-50.
Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM. PMID: 23197725; PMCID: PMC3586232.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. PLoS One. 2012; 7(11):e48782.
Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, Laferla FM, Cai H, Rose GM, Patrylo PR. PMID: 23155407; PMCID: PMC3498246.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Animal models of Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Nov 01; 2(11).
LaFerla FM, Green KN. PMID: 23002015; PMCID: PMC3543097.
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PubMed Mentions:
182 Fields:
Translation:
HumansAnimalsCells
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Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function. Brain Res. 2012 Dec 13; 1489:8-16.
Neely Kayala KM, Dickinson GD, Minassian A, Walls KC, Green KN, Laferla FM. PMID: 23103503; PMCID: PMC3516298.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp Neurol. 2013 Jan; 239:133-8.
Medeiros R, LaFerla FM. PMID: 23063604.
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PubMed Mentions:
95 Fields:
Translation:
AnimalsCells
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The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98.
Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. PMID: 23062850; PMCID: PMC3562382.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimals
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Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging. Acta Neuropathol. 2013 Jan; 125(1):145-57.
Solé-Domènech S, Sjövall P, Vukojevic V, Fernando R, Codita A, Salve S, Bogdanovic N, Mohammed AH, Hammarström P, Nilsson KP, LaFerla FM, Jacob S, Berggren PO, Giménez-Llort L, Schalling M, Terenius L, Johansson B. PMID: 22996963.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aβ(1-42) and tau. Biochem Biophys Res Commun. 2012 Oct 12; 427(1):218-22.
Chakravarthy B, Gaudet C, Ménard M, Brown L, Atkinson T, Laferla FM, Ito S, Armato U, Dal Prà I, Whitfield J. PMID: 22995307.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease. Learn Mem. 2012 Sep 14; 19(10):453-60.
Guzmán-Ramos K, Moreno-Castilla P, Castro-Cruz M, McGaugh JL, Martínez-Coria H, LaFerla FM, Bermúdez-Rattoni F. PMID: 22984283.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimals
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Preclinical success against Alzheimer's disease with an old drug. N Engl J Med. 2012 Aug 09; 367(6):570-2.
LaFerla FM. PMID: 22873540.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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APP knockout mice experience acute mortality as the result of ischemia. PLoS One. 2012; 7(8):e42665.
Koike MA, Lin AJ, Pham J, Nguyen E, Yeh JJ, Rahimian R, Tromberg BJ, Choi B, Green KN, LaFerla FM. PMID: 22912719; PMCID: PMC3415410.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener. 2012 Aug 06; 7:37.
Rasool S, Albay R, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. PMID: 22866920; PMCID: PMC3476970.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCellsPHPublic Health
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Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology. PLoS One. 2012; 7(8):e39566.
Castello NA, Green KN, LaFerla FM. PMID: 22870188; PMCID: PMC3411687.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem. 2012 Aug 31; 287(36):30317-27.
Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, LaFerla FM. PMID: 22753410; PMCID: PMC3436283.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012 Aug; 181(2):616-25.
Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. PMID: 22688056.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways. Life Sci. 2012 Dec 10; 91(23-24):1177-86.
Takamura A, Sato Y, Watabe D, Okamoto Y, Nakata T, Kawarabayashi T, Oddo S, Laferla FM, Shoji M, Matsubara E. PMID: 22579764.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications. J Am Chem Soc. 2012 May 02; 134(17):7467-79.
Alonso E, Fuwa H, Vale C, Suga Y, Goto T, Konno Y, Sasaki M, LaFerla FM, Vieytes MR, Giménez-Llort L, Botana LM. PMID: 22475455.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr). 2013 Jun; 35(3):519-31.
Walker MP, LaFerla FM, Oddo SS, Brewer GJ. PMID: 22237558; PMCID: PMC3636384.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr Pharm Des. 2012; 18(8):1131-47.
Kitazawa M, Medeiros R, Laferla FM. PMID: 22288400; PMCID: PMC4437619.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimals
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Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice. J Alzheimers Dis. 2012; 32(2):267-72.
Girão da Cruz MT, Jordão J, Dasilva KA, Ayala-Grosso CA, Ypsilanti A, Weng YQ, Laferla FM, McLaurin J, Aubert I. PMID: 22776965.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention. J Alzheimers Dis. 2012; 32(1):217-32.
Wolf AB, Braden BB, Bimonte-Nelson H, Kusne Y, Young N, Engler-Chiurazzi E, Garcia AN, Walker DG, Moses GS, Tran H, LaFerla F, Lue L, Emerson Lombardo N, Valla J. PMID: 22796872; PMCID: PMC3774548.
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PubMed Mentions:
7 Fields:
Translation:
Animals
-
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011 Dec 15; 187(12):6539-49.
Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 22095718; PMCID: PMC4072218.
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PubMed Mentions:
231 Fields:
Translation:
HumansAnimalsCells
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Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiol Aging. 2012 Jun; 33(6):1121.e1-12.
Cassano T, Serviddio G, Gaetani S, Romano A, Dipasquale P, Cianci S, Bellanti F, Laconca L, Romano AD, Padalino I, LaFerla FM, Nicoletti F, Cuomo V, Vendemiale G. PMID: 22035587.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro. Neurochem Int. 2011 Dec; 59(7):1056-65.
Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM. PMID: 21907746.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta. 2012 May; 1820(5):553-64.
Coskun P, Wyrembak J, Schriner SE, Chen HW, Marciniack C, Laferla F, Wallace DC. PMID: 21871538; PMCID: PMC3270155.
View in:
PubMed Mentions:
154 Fields:
Translation:
HumansAnimalsCells
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The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides. PLoS One. 2011; 6(7):e22370.
Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, LaFerla FM, Taraglio S, Dotti CG, Di Cunto F. PMID: 21829458; PMCID: PMC3145648.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011 Sep; 7(5):521-531.e1.
Tang JX, Mardini F, Caltagarone BM, Garrity ST, Li RQ, Bianchi SL, Gomes O, Laferla FM, Eckenhoff RG, Eckenhoff MF. PMID: 21745760; PMCID: PMC3167023.
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PubMed Mentions:
31 Fields:
Translation:
Animals
-
BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology. Neurotox Res. 2012 Feb; 21(2):160-74.
Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX. PMID: 21725719; PMCID: PMC3227764.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Olfactory memory is impaired in a triple transgenic model of Alzheimer disease. Behav Brain Res. 2011 Oct 31; 224(2):408-12.
Cassano T, Romano A, Macheda T, Colangeli R, Cimmino CS, Petrella A, LaFerla FM, Cuomo V, Gaetani S. PMID: 21741995.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
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Animal models of Alzheimer's disease. Int J Alzheimers Dis. 2010; 2010:606357.
Casadesus G, Arendash G, Laferla F, McDonald M. PMID: 21804934; PMCID: PMC3143420.
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PubMed Mentions:
4
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Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011 Jun 29; 31(26):9513-25.
Tran HT, LaFerla FM, Holtzman DM, Brody DL. PMID: 21715616; PMCID: PMC3146343.
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PubMed Mentions:
128 Fields:
Translation:
AnimalsCells
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Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011 Aug; 179(2):980-91.
Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. PMID: 21704011; PMCID: PMC3157199.
View in:
PubMed Mentions:
53 Fields:
Translation:
Animals
-
The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease. Cell Physiol Biochem. 2011; 27(6):783-94.
Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM. PMID: 21691095.
View in:
PubMed Mentions:
17 Fields:
Translation:
Animals
-
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem. 2011 Jul 08; 286(27):24264-74.
Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. PMID: 21606494; PMCID: PMC3129207.
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PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol. 2011 Jun; 178(6):2811-22.
Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM. PMID: 21531375; PMCID: PMC3124234.
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PubMed Mentions:
113 Fields:
Translation:
AnimalsCells
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Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011 May 09; 495(1):55-9.
Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM. PMID: 21419194; PMCID: PMC3099741.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo. Ann Neurol. 2011 May; 69(5):831-44.
Green KN, Khashwji H, Estrada T, Laferla FM. PMID: 21416488.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Proflavine derivatives as fluorescent imaging agents of amyloid deposits. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2203-6.
Garin D, Oukhatar F, Mahon AB, Try AC, Dubois-Dauphin M, Laferla FM, Demeunynck M, Sallanon MM, Chierici S. PMID: 21435875.
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PubMed Mentions:
1 Fields:
Translation:
Animals
-
Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner. J Neurosci. 2011 Feb 23; 31(8):2781-91.
Neely KM, Green KN, LaFerla FM. PMID: 21414900; PMCID: PMC3064964.
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PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
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Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer's disease. Ann Biomed Eng. 2011 Apr; 39(4):1349-57.
Lin AJ, Koike MA, Green KN, Kim JG, Mazhar A, Rice TB, LaFerla FM, Tromberg BJ. PMID: 21331663; PMCID: PMC3069335.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimals
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Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation. Ann Neurol. 2011 Feb; 69(2):248-56.
Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J. PMID: 21387370.
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PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
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Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease. J Proteomics. 2011 Apr 01; 74(4):466-79.
Chou JL, Shenoy DV, Thomas N, Choudhary PK, Laferla FM, Goodman SR, Breen GA. PMID: 21237293.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. J Alzheimers Dis. 2011; 24(3):421-54.
García-Mesa Y, López-Ramos JC, Giménez-Llort L, Revilla S, Guerra R, Gruart A, Laferla FM, Cristòfol R, Delgado-García JM, Sanfeliu C. PMID: 21297257.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimals
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Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17; 5(11):e14015.
Parachikova A, Green KN, Hendrix C, LaFerla FM. PMID: 21103342; PMCID: PMC2984445.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
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Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One. 2010 Nov 16; 5(11):e15477.
Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J. PMID: 21103384; PMCID: PMC2982845.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. J Neurosci. 2010 Oct 20; 30(42):13966-76.
Piedrahita D, Hernández I, López-Tobón A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gómez JC, Kosik KS, Cardona-Gómez GP. PMID: 20962218; PMCID: PMC3003593.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010 Nov; 120(5):605-21.
Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I. PMID: 20697724.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 2010 Aug 06; 1347:179-85.
Nicholson RM, Kusne Y, Nowak LA, LaFerla FM, Reiman EM, Valla J. PMID: 20677372; PMCID: PMC2974951.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimals
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Pathways linking Abeta and tau pathologies. Biochem Soc Trans. 2010 Aug; 38(4):993-5.
LaFerla FM. PMID: 20658991.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes. Brain Res. 2010 Aug 12; 1348:149-55.
Sterniczuk R, Antle MC, Laferla FM, Dyck RH. PMID: 20558146.
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PubMed Mentions:
105 Fields:
Translation:
HumansAnimals
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The role of tau in Alzheimer's disease and related disorders. CNS Neurosci Ther. 2011 Oct; 17(5):514-24.
Medeiros R, Baglietto-Vargas D, LaFerla FM. PMID: 20553310; PMCID: PMC4072215.
View in:
PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes. Brain Res. 2010 Aug 12; 1348:139-48.
Sterniczuk R, Dyck RH, Laferla FM, Antle MC. PMID: 20471965.
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PubMed Mentions:
89 Fields:
Translation:
HumansAnimals
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Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26; 30(21):7281-9.
Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. PMID: 20505094; PMCID: PMC3308018.
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PubMed Mentions:
263 Fields:
Translation:
HumansAnimalsCells
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Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010 Jul; 177(1):300-10.
Koike MA, Green KN, Blurton-Jones M, Laferla FM. PMID: 20472896; PMCID: PMC2893673.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci. 2010 Apr; 13(4):411-3.
Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. PMID: 20305648; PMCID: PMC4072212.
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PubMed Mentions:
297 Fields:
Translation:
AnimalsCells
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Alzheimer's disease. N Engl J Med. 2010 Jan 28; 362(4):329-44.
Querfurth HW, LaFerla FM. PMID: 20107219.
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PubMed Mentions:
1946 Fields:
Translation:
HumansCells
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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3081-6.
Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. PMID: 20133765; PMCID: PMC2840286.
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PubMed Mentions:
96 Fields:
Translation:
HumansAnimals
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Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One. 2010 Jan 20; 5(1):e8593.
Hasegawa T, Mikoda N, Kitazawa M, LaFerla FM. PMID: 20098691; PMCID: PMC2808336.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis. 2010; 19(3):915-25.
Chakravarthy B, Gaudet C, Ménard M, Atkinson T, Brown L, Laferla FM, Armato U, Whitfield J. PMID: 20157247.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010; 21(2):527-42.
Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN. PMID: 20555131; PMCID: PMC4085054.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010 Feb; 176(2):870-80.
Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM. PMID: 20042680; PMCID: PMC2808092.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009 Dec 28; 187(7):1083-99.
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. PMID: 20026656; PMCID: PMC2806289.
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PubMed Mentions:
192 Fields:
Translation:
HumansAnimalsCells
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Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010 May; 30(4):577-90.
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM. PMID: 19943189.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Inhaled anesthetic potency in aged Alzheimer mice. Anesth Analg. 2010 Feb 01; 110(2):427-30.
Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB. PMID: 19820240; PMCID: PMC4899815.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience. 2009 Dec 15; 164(3):1334-46.
Robertson RT, Baratta J, Yu J, LaFerla FM. PMID: 19772895; PMCID: PMC2784206.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem. 2009 Oct 23; 284(43):29427-36.
Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. PMID: 19710014; PMCID: PMC2785575.
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PubMed Mentions:
81 Fields:
Translation:
HumansCells
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Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. Biol Psychiatry. 2010 Mar 15; 67(6):513-21.
España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA. PMID: 19664757.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9.
Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. PMID: 19633196; PMCID: PMC2715325.
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PubMed Mentions:
346 Fields:
Translation:
AnimalsCells
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Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15; 183(2):1375-83.
Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM, Taylor SM, Woodruff TM, Tenner AJ. PMID: 19561098; PMCID: PMC4067320.
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PubMed Mentions:
146 Fields:
Translation:
AnimalsCells
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Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. Neurochem Int. 2009 Dec; 55(7):476-82.
Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. PMID: 19442696.
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PubMed Mentions:
71 Fields:
Translation:
AnimalsCells
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Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J Neurosci. 2009 May 13; 29(19):6132-41.
Kitazawa M, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19439591; PMCID: PMC3049190.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. J Neurosci Res. 2009 May 01; 87(6):1462-73.
Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. PMID: 19021293; PMCID: PMC2832596.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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M1 agonists as a potential disease-modifying therapy for Alzheimer's disease. Curr Alzheimer Res. 2009 Apr; 6(2):112-7.
Caccamo A, Fisher A, LaFerla FM. PMID: 19355845.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009 Apr; 34(1):163-77.
McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. PMID: 19320056; PMCID: PMC2948857.
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PubMed Mentions:
136 Fields:
Translation:
AnimalsCells
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Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease. Neuropharmacology. 2009 Mar; 56(4):808-13.
Bourasset F, Ouellet M, Tremblay C, Julien C, Do TM, Oddo S, LaFerla F, Calon F. PMID: 19705573.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 2009 Mar; 108(6):1550-60.
Kitazawa M, Cheng D, Laferla FM. PMID: 19183260; PMCID: PMC4096128.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canines. J Alzheimers Dis. 2009; 16(2):315-23.
Nuntagij P, Oddo S, LaFerla FM, Kotchabhakdi N, Ottersen OP, Torp R. PMID: 19221421.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. J Alzheimers Dis. 2009; 16(3):541-9.
Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. PMID: 19276549.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle. Neurobiol Aging. 2010 Dec; 31(12):2080-90.
Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW. PMID: 19108934; PMCID: PMC2901770.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci. 2008 Nov 19; 28(47):12163-75.
Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19020010; PMCID: PMC6671718.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimals
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Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008 Nov 05; 28(45):11500-10.
Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. PMID: 18987186; PMCID: PMC2617713.
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PubMed Mentions:
168 Fields:
Translation:
HumansAnimalsCells
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Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82.
Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. PMID: 18974297; PMCID: PMC2626388.
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PubMed Mentions:
116 Fields:
Translation:
HumansAnimalsCells
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Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem. 2009 Mar 06; 284(10):6033-7.
Morrissette DA, Parachikova A, Green KN, LaFerla FM. PMID: 18948253.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimals
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Validation of a 2-day water maze protocol in mice. Behav Brain Res. 2009 Jan 23; 196(2):220-7.
Gulinello M, Gertner M, Mendoza G, Schoenfeld BP, Oddo S, LaFerla F, Choi CH, McBride SM, Faber DS. PMID: 18831990; PMCID: PMC4303046.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimals
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Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS One. 2008 Aug 13; 3(8):e2935.
Rodríguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A. PMID: 18698410; PMCID: PMC2492828.
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PubMed Mentions:
169 Fields:
Translation:
HumansAnimals
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Linking calcium to Abeta and Alzheimer's disease. Neuron. 2008 Jul 31; 59(2):190-4.
Green KN, LaFerla FM. PMID: 18667147.
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PubMed Mentions:
122 Fields:
Translation:
HumansAnimals
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Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology. Brain Pathol. 2009 Jul; 19(3):421-30.
Oddo S, Caccamo A, Cheng D, LaFerla FM. PMID: 18657136; PMCID: PMC4072242.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Experience-dependent regulation of vesicular zinc in male and female 3xTg-AD mice. Neurobiol Aging. 2010 Apr; 31(4):605-13.
Nakashima AS, Oddo S, Laferla FM, Dyck RH. PMID: 18603329.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta. Ann Neurol. 2008 Jul; 64(1):15-24.
Kitazawa M, Trinh DN, LaFerla FM. PMID: 18318434.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16.
Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18591429; PMCID: PMC2442205.
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PubMed Mentions:
134 Fields:
Translation:
HumansAnimalsCells
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Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res. 2008 Jun 24; 1216:92-103.
Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y. PMID: 18486110.
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PubMed Mentions:
142 Fields:
Translation:
Animals
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Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 01; 1207:225-36.
McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. PMID: 18374906; PMCID: PMC2587244.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimalsCells
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Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 2007 Nov 28; 27(48):13357-65.
Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ. PMID: 18045930; PMCID: PMC6673397.
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PubMed Mentions:
170 Fields:
Translation:
Animals
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Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. J Neurochem. 2008 Apr; 105(1):262-71.
Lopez JR, Lyckman A, Oddo S, Laferla FM, Querfurth HW, Shtifman A. PMID: 18021291.
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PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
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Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33.
Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. PMID: 17978032; PMCID: PMC6673368.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration. Eur J Neurosci. 2007 Nov; 26(9):2458-68.
Takata K, Hirata-Fukae C, Becker AG, Chishiro S, Gray AJ, Nishitomi K, Franz AH, Sakaguchi G, Kato A, Mattson MP, Laferla FM, Aisen PS, Kitamura Y, Matsuoka Y. PMID: 17970733.
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PubMed Mentions:
7 Translation:
HumansAnimalsCells
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Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68.
Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. PMID: 17953662.
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PubMed Mentions:
89 Fields:
Translation:
HumansCells
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Age-related accumulation of Reelin in amyloid-like deposits. Neurobiol Aging. 2009 May; 30(5):697-716.
Knuesel I, Nyffeler M, Mormède C, Muhia M, Meyer U, Pietropaolo S, Yee BK, Pryce CR, LaFerla FM, Marighetto A, Feldon J. PMID: 17904250.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem. 2007 Nov; 103(3):1132-44.
Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C. PMID: 17683481.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
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Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci. 2007 Jul; 8(7):499-509.
LaFerla FM, Green KN, Oddo S. PMID: 17551515.
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PubMed Mentions:
792 Fields:
Translation:
HumansAnimalsCells
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Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis. 2007 Oct; 28(1):76-82.
Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, McGaugh JL, LaFerla FM. PMID: 17659878; PMCID: PMC2756084.
View in:
PubMed Mentions:
129 Fields:
Translation:
Animals
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Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging. 2008 Nov; 29(11):1607-18.
Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. PMID: 17544172; PMCID: PMC2664168.
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PubMed Mentions:
168 Fields:
Translation:
AnimalsCells
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Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007 May; 170(5):1669-75.
Caccamo A, Oddo S, Tran LX, LaFerla FM. PMID: 17456772; PMCID: PMC1854961.
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PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
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Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007 Aug; 102(4):1053-63.
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM. PMID: 17472708.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci. 2007 Apr 18; 27(16):4385-95.
Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM. PMID: 17442823; PMCID: PMC6672302.
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PubMed Mentions:
118 Fields:
Translation:
AnimalsCells
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Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Ann N Y Acad Sci. 2007 Feb; 1097:265-77.
Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F. PMID: 17413028.
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PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
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Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice. J Neurosci. 2007 Jan 24; 27(4):751-61.
Billings LM, Green KN, McGaugh JL, LaFerla FM. PMID: 17251414; PMCID: PMC6672918.
View in:
PubMed Mentions:
53 Fields:
Translation:
Animals
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Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2007 Apr; 26(1):212-20.
Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP. PMID: 17306982.
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PubMed Mentions:
254 Fields:
Translation:
HumansAnimals
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Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci. 2007; 31(2):165-70.
Matsuoka Y, Gray AJ, Hirata-Fukae C, Minami SS, Waterhouse EG, Mattson MP, LaFerla FM, Gozes I, Aisen PS. PMID: 17478890.
View in:
PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models. Subcell Biochem. 2007; 45:507-21.
Green KN, Smith IF, Laferla FM. PMID: 18193650.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci. 2006 Dec 20; 26(51):13384-9.
Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ. PMID: 17182789; PMCID: PMC6674990.
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PubMed Mentions:
69 Fields:
Translation:
Animals
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Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res. 2006 Dec; 3(5):437-48.
Blurton-Jones M, Laferla FM. PMID: 17168643.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006 Dec 22; 281(51):39413-23.
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM. PMID: 17056594.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid. Neurosci Biobehav Rev. 2007; 31(1):125-47.
Giménez-Llort L, Blázquez G, Cañete T, Johansson B, Oddo S, Tobeña A, LaFerla FM, Fernández-Teruel A. PMID: 17055579.
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PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
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Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006 Aug 30; 26(35):9047-56.
Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM. PMID: 16943563; PMCID: PMC6675335.
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PubMed Mentions:
280 Fields:
Translation:
AnimalsCells
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Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB J. 2006 Oct; 20(12):2165-7.
Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW. PMID: 16940437.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci. 2006 Jun 14; 26(24):6533-42.
Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. PMID: 16775141; PMCID: PMC6674046.
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PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
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Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol. 2006 Jun; 168(6):1986-97.
Kitazawa M, Green KN, Caccamo A, LaFerla FM. PMID: 16723713; PMCID: PMC1606633.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci. 2006 May 10; 26(19):5180-9.
Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. PMID: 16687509; PMCID: PMC6674246.
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PubMed Mentions:
182 Fields:
Translation:
AnimalsCells
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M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 02; 49(5):671-82.
Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. PMID: 16504943.
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PubMed Mentions:
153 Fields:
Translation:
HumansAnimals
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The role of nicotinic acetylcholine receptors in Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):172-9.
Oddo S, LaFerla FM. PMID: 16448808.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol. 2006 Jan; 168(1):184-94.
Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM. PMID: 16400022; PMCID: PMC1592652.
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PubMed Mentions:
121 Fields:
Translation:
AnimalsCells
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Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad. Neuron. 2005 Dec 08; 48(5):711-2.
LaFerla FM, Kitazawa M. PMID: 16337907.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006 Jan 20; 281(3):1599-604.
Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. PMID: 16282321.
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PubMed Mentions:
169 Fields:
Translation:
HumansAnimalsCells
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Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23.
Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. PMID: 16232318; PMCID: PMC1276812.
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PubMed Mentions:
118 Fields:
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Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Sep 28; 25(39):8843-53.
Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. PMID: 16192374; PMCID: PMC6725603.
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PubMed Mentions:
340 Fields:
Translation:
AnimalsCells
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Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium. 2005 Sep-Oct; 38(3-4):427-37.
Smith IF, Green KN, LaFerla FM. PMID: 16125228.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimals
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Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem. 2005 Sep; 94(6):1711-8.
Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM. PMID: 16156741.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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An array of genes implicated in Alzheimer's disease. Neurobiol Aging. 2006 Aug; 27(8):1078-80.
LaFerla FM. PMID: 16112251.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model. Neurobiol Aging. 2006 Mar; 27(3):423-32.
Sugarman MC, Kitazawa M, Baker M, Caiozzo VJ, Querfurth HW, LaFerla FM. PMID: 15950323.
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Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May; 26(5):645-54.
Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. PMID: 15708439.
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PubMed Mentions:
121 Fields:
Translation:
HumansAnimals
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Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol Med. 2005 Apr; 11(4):170-6.
LaFerla FM, Oddo S. PMID: 15823755.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimalsCells
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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 03; 45(5):675-88.
Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. PMID: 15748844.
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PubMed Mentions:
564 Fields:
Translation:
AnimalsCells
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Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):3046-51.
Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, LaFerla FM. PMID: 15705720; PMCID: PMC549455.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann N Y Acad Sci. 2004 Dec; 1035:85-103.
Kitazawa M, Yamasaki TR, LaFerla FM. PMID: 15681802.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Amyloid beta-peptide: the inside story. Curr Alzheimer Res. 2004 Nov; 1(4):231-9.
Tseng BP, Kitazawa M, LaFerla FM. PMID: 15975052.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1145-52.
Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PMID: 15336962.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron. 2004 Aug 05; 43(3):321-32.
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. PMID: 15294141.
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PubMed Mentions:
319 Fields:
Translation:
AnimalsCells
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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30.
Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619; PMCID: PMC437967.
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PubMed Mentions:
253 Fields:
Translation:
HumansAnimalsCells
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Live discussion: how the other half lives - or the what, how, and where, of the AbetaPP intracellular domain. J Alzheimers Dis. 2004 Apr; 6(2):193-9.
Bishop G, Coleman P, Crutcher K, David D, Kinoshita J, LaFerla F, Leissring M, Shepherd J, Therianos S, Wang R, Wilson A, Zhu M. PMID: 15171221.
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PubMed Mentions: Fields:
Translation:
Humans
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Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004 Feb; 113(4):582-90.
Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. PMID: 14966567; PMCID: PMC338266.
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PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci. 2004 Jan 14; 24(2):508-13.
Stutzmann GE, Caccamo A, LaFerla FM, Parker I. PMID: 14724250; PMCID: PMC6729995.
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PubMed Mentions:
125 Fields:
Translation:
AnimalsCells
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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003 Dec; 24(8):1063-70.
Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. PMID: 14643377.
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PubMed Mentions:
411 Fields:
Translation:
HumansAnimalsCells
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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21.
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PMID: 12895417.
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PubMed Mentions:
1889 Fields:
Translation:
HumansAnimalsCells
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Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. J Neurosci. 2003 Feb 01; 23(3):758-65.
Stutzmann GE, LaFerla FM, Parker I. PMID: 12574404; PMCID: PMC6741910.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci. 2002 Nov; 3(11):862-72.
LaFerla FM. PMID: 12415294.
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PubMed Mentions:
384 Fields:
Translation:
HumansAnimalsCells
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Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6334-9.
Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. PMID: 11972038; PMCID: PMC122949.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4697-702.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. PMID: 11917117; PMCID: PMC123710.
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PubMed Mentions:
96 Fields:
Translation:
AnimalsCells
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Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling. Nat Biotechnol. 2001 Jul; 19(7):645-9.
Marchant JS, Stutzmann GE, Leissring MA, LaFerla FM, Parker I. PMID: 11433276.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling. Neurobiol Dis. 2001 Jun; 8(3):469-78.
Leissring MA, LaFerla FM, Callamaras N, Parker I. PMID: 11442355.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-gamma. J Mol Neurosci. 2000 Aug; 15(1):45-59.
LaFerla FM, Sugarman MC, Lane TE, Leissring MA. PMID: 11211236.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8590-3.
Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM. PMID: 10900016; PMCID: PMC26992.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. Biochemistry. 2000 May 23; 39(20):5988-94.
Cribbs DH, Azizeh BY, Cotman CW, LaFerla FM. PMID: 10821670.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol. 2000 May 15; 149(4):793-8.
Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. PMID: 10811821; PMCID: PMC2174559.
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PubMed Mentions:
115 Fields:
Translation:
AnimalsCells
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Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2000 May; 23(5):222-9.
Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD. PMID: 10782128.
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PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J Biol Chem. 1999 Nov 12; 274(46):32535-8.
Leissring MA, Parker I, LaFerla FM. PMID: 10551803.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999 Mar; 72(3):1061-8.
Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. PMID: 10037477.
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PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
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Herpes simplex virus infections and Alzheimer's disease. Implications for drug treatment and immunotherapy. Drugs Aging. 1998 Sep; 13(3):193-8.
Leissring MA, Sugarman MC, LaFerla FM. PMID: 9789723.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest. 1997 Jul 15; 100(2):310-20.
LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G. PMID: 9218507; PMCID: PMC508193.
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PubMed Mentions:
50 Fields:
Translation:
HumansCells
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Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Exp Neurol. 1997 Jan; 143(1):37-44.
Weber LL, Leissring MA, Yang AJ, Glabe CG, Cribbs DH, LaFerla FM. PMID: 9000444.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest. 1996 Oct 01; 98(7):1626-32.
LaFerla FM, Hall CK, Ngo L, Jay G. PMID: 8833912; PMCID: PMC507596.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Injury induces presenilin-1 gene expression in mouse brain. Neuroreport. 1996 Jul 29; 7(11):1773-6.
Cribbs DH, Chen LS, Cotman CW, LaFerla FM. PMID: 8905662.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. Am J Pathol. 1996 Jun; 148(6):1797-806.
Cribbs DH, Chen LS, Bende SM, LaFerla FM. PMID: 8669467; PMCID: PMC1861636.
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PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
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The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet. 1995 Jan; 9(1):21-30.
LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G. PMID: 7704018.
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PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells