Loading...

Frank M. LaFerla

Title(s)Dean, School of Biological Sciences, School of Biological Sciences Dean's Office
Address5120 Natural Sciences II
Zot 1450
Irvine CA 92697
Phone(949) 824-5315
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH/NIA P30AG066519Jun 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    UC Irvine AD Translational Center for Disease Model Resources
    NIH/NIA U54AG054349Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    The impact of endocytic protein Tom1 on Alzheimer's disease
    NIH/NIA R21AG054884Sep 30, 2016 - Apr 30, 2018
    Role: Principal Investigator
    A Neurolucida and Stereo Investigator Imaging System with MicroLucida
    NIH S10OD010420May 15, 2012 - May 14, 2013
    Role: Principal Investigator
    Learning and Memory Impairments in Transgenic AD Models
    NIH/NIA R01AG027544Apr 1, 2007 - Mar 31, 2012
    Role: Principal Investigator
    Gene Interactions in a Model of Alzheimer's Disease
    NIH/NIA R01AG021982Jul 1, 2003 - May 31, 2014
    Role: Principal Investigator
    Modulating IBM pathology in transgenic mice
    NIH/NIA R01AG020335Mar 1, 2002 - Feb 28, 2007
    Role: Principal Investigator
    Regulation of calcium signaling pathways by presenilins
    NIH/NIA R01AG017968Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH/NIA P50AG016573Apr 15, 2000 - Mar 31, 2020
    Role: Principal Investigator
    TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITIS
    NIH/NIA R29AG015409Apr 15, 1998 - Mar 31, 2003
    Role: Principal Investigator
    VIRAL COFACTOR AND SPORADIC ALZHEIMERS DISEASE
    NIH/NIA R03AG014864Jul 15, 1997 - Jun 30, 1998
    Role: Principal Investigator
    TRANSGENIC MOUSE MODEL OF INCLUSION BODY MYOSITIS
    NIH/NIA R03AG014508Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    Core A: Administrative Core
    NIH P50-16
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13118. Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. PMID: 32087004.
      View in: PubMed   Mentions: 2     Fields:    
    2. Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):3917-3919. Martini AC, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 32047040.
      View in: PubMed   Mentions:    Fields:    
    3. BrightFocus Alzheimer's Fast Track 2019. Mol Neurodegener. 2019 12 20; 14(1):48. Whitaker KW, LaFerla FM, Steinbusch HWM, Lemere CA, Bovenkamp DE. PMID: 31861987.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Intra- and extracellular ß-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 11 04; 9(1):15936. Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. PMID: 31685865.
      View in: PubMed   Mentions: 1     Fields:    
    5. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21198-21206. Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 31570577.
      View in: PubMed   Mentions: 3     Fields:    
    6. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 Sep; 51(9):1423-1424. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. PMID: 31417202.
      View in: PubMed   Mentions: 1     Fields:    
    7. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. PMID: 30820047.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    8. Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. Aging Cell. 2019 06; 18(3):e12919. Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM. PMID: 30809950.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease. Sci Rep. 2019 02 04; 9(1):1311. Stimmell AC, Baglietto-Vargas D, Moseley SC, Lapointe V, Thompson LM, LaFerla FM, McNaughton BL, Wilber AA. PMID: 30718609.
      View in: PubMed   Mentions: 1     Fields:    
    10. Astrocytes: From the Physiology to the Disease. Curr Alzheimer Res. 2019; 16(8):675-698. Trujillo-Estrada L, Gomez-Arboledas A, Forner S, Martini AC, Gutierrez A, Baglietto-Vargas D, LaFerla FM. PMID: 31470787.
      View in: PubMed   Mentions:    Fields:    
    11. Sex-dependent co-occurrence of hypoxia and ß-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3?×?Tg-AD mouse model of Alzheimer's disease. Mol Cell Neurosci. 2018 10; 92:67-81. Frontiñán-Rubio J, Sancho-Bielsa FJ, Peinado JR, LaFerla FM, Giménez-Llort L, Durán-Prado M, Alcain FJ. PMID: 29953929.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 08; 17(4):e12791. Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. PMID: 29877034.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-ß and Tau in a Mouse Model of Alzheimer's Disease. Mol Nutr Food Res. 2018 06; 62(12):e1800240. Lee S, Choi BR, Kim J, LaFerla FM, Park JHY, Han JS, Lee KW, Kim J. PMID: 29714053.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Sci Rep. 2018 04 24; 8(1):6431. Van der Jeugd A, Parra-Damas A, Baeta-Corral R, Soto-Faguás CM, Ahmed T, LaFerla FM, Giménez-Llort L, D'Hooge R, Saura CA. PMID: 29691439.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Mol Neurodegener. 2018 03 01; 13(1):11. Sosna J, Philipp S, Albay R, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. PMID: 29490706.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    16. Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease. J Alzheimers Dis. 2018; 64(s1):S365-S378. Martini AC, Forner S, Trujillo-Estrada L, Baglietto-Vargas D, LaFerla FM. PMID: 29504540.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. 2017 12 19; 7(1):17762. Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. PMID: 29259249.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    18. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports. 2018 01 09; 10(1):58-72. Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. PMID: 29233555.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, et al. PMID: 28714976.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    20. Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony. Trends Neurosci. 2017 06; 40(6):347-357. Forner S, Baglietto-Vargas D, Martini AC, Trujillo-Estrada L, LaFerla FM. PMID: 28494972.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    21. Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. Mol Nutr Food Res. 2017 02; 61(2). Kim J, Lee S, Choi BR, Yang H, Hwang Y, Park JH, LaFerla FM, Han JS, Lee KW, Kim J. PMID: 27735126.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 11 29; 6:37889. Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. PMID: 27897204.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease. Neuroscience. 2016 08 04; 329:284-93. Manuel I, Lombardero L, LaFerla FM, Giménez-Llort L, Rodríguez-Puertas R. PMID: 27223629.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    24. Diabetes and Alzheimer's disease crosstalk. Neurosci Biobehav Rev. 2016 May; 64:272-87. Baglietto-Vargas D, Shi J, Yaeger DM, Ager R, LaFerla FM. PMID: 26969101.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    25. AF710B, a Novel M1/s1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease. Neurodegener Dis. 2016; 16(1-2):95-110. Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R. PMID: 26606130.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Accelerating stem cell trials for Alzheimer's disease. Lancet Neurol. 2016 02; 15(2):219-230. Hunsberger JG, Rao M, Kurtzberg J, Bulte JWM, Atala A, LaFerla FM, Greely HT, Sawa A, Gandy S, Schneider LS, Doraiswamy PM. PMID: 26704439.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    27. Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1ß in the aged hippocampus. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5078-87. Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J, Cotman CW. PMID: 26305968.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    28. Short-term modern life-like stress exacerbates Aß-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015 Sep; 134(5):915-26. Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. PMID: 26077803.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    29. Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model. Brain Res Bull. 2015 Aug; 117:10-5. Martinez-Coria H, Yeung ST, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM. PMID: 26162480.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    30. COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model. J Neurochem. 2015 Mar; 132(5):609-18. Garin D, Virgone-Carlotta A, Gözel B, Oukhatar F, Perret P, Marti-Battle D, Touret M, Millet P, Dubois-Dauphin M, Meyronet D, Streichenberger N, Laferla FM, Demeunynck M, Chierici S, Sallanon Moulin M, Ghezzi C. PMID: 25258048.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. Alzheimer-associated Aß oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015 Feb; 7(2):190-210. Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. PMID: 25617315.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    32. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    33. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. 2015 Jul; 25(7):813-26. Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. PMID: 25530343.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    34. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    35. Neural HO-1/sterol interactions in vivo: implications for Alzheimer's disease. Neuroscience. 2014 Nov 07; 280:40-9. Hascalovici JR, Song W, Liberman A, Vaya J, Khatib S, Holcroft C, Laferla F, Schipper HM. PMID: 25218961.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model. PLoS One. 2014; 9(9):e106009. Myczek K, Yeung ST, Castello N, Baglietto-Vargas D, LaFerla FM. PMID: 25184527.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2014 Nov; 71:110-30. Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, Iqbal K. PMID: 25046994.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    38. Optical imaging in an Alzheimer's mouse model reveals amyloid-ß-dependent vascular impairment. Neurophotonics. 2014 Jul; 1(1):011005. Lin AJ, Liu G, Castello NA, Yeh JJ, Rahimian R, Lee G, Tsay V, Durkin AJ, Choi B, LaFerla FM, Chen Z, Green KN, Tromberg BJ. PMID: 25133200.
      View in: PubMed   Mentions:
    39. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neurosci Lett. 2014 Jul 11; 575:96-100. Walls KC, Ager RR, Vasilevko V, Cheng D, Medeiros R, LaFerla FM. PMID: 24887583.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    40. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2014 Apr 16; 5(2):46. Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. PMID: 25022790.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    41. 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS One. 2014; 9(3):e91453. Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN, LaFerla FM. PMID: 24614170.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease. Neurobiol Dis. 2014 Apr; 64:107-17. Chabrier MA, Cheng D, Castello NA, Green KN, LaFerla FM. PMID: 24440055.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    43. Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol. 2014 Mar; 184(3):819-26. Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM. PMID: 24412516.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    44. Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2014; 40(3):701-12. Bedse G, Romano A, Cianci S, Lavecchia AM, Lorenzo P, Elphick MR, Laferla FM, Vendemiale G, Grillo C, Altieri F, Cassano T, Gaetani S. PMID: 24496074.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    45. Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J Alzheimers Dis. 2014; 42(4):1229-38. Rodriguez-Ortiz CJ, Baglietto-Vargas D, Martinez-Coria H, LaFerla FM, Kitazawa M. PMID: 25024332.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    46. Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain. Neuroscience. 2014 Feb 14; 259:214-22. Yeung ST, Myczek K, Kang AP, Chabrier MA, Baglietto-Vargas D, Laferla FM. PMID: 24316470.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    47. In vivo optical signatures of neuronal death in a mouse model of Alzheimer's disease. Lasers Surg Med. 2014 Jan; 46(1):27-33. Lin AJ, Castello NA, Lee G, Green KN, Durkin AJ, Choi B, LaFerla F, Tromberg BJ. PMID: 24284732.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    48. a7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014 Feb; 184(2):520-9. Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. PMID: 24269557.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    49. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014 Feb; 62:407-15. Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. PMID: 24176788.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aß deposition and tau pathology in 3xTg-AD mice. J Neurochem. 2013 Aug; 126(4):473-82. Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG. PMID: 23672786.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCellsPHPublic Health
    51. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15. Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. PMID: 23747512.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study. Cereb Cortex. 2014 Sep; 24(9):2476-88. Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y. PMID: 23595620.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    53. Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May; 182(5):1780-9. Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM. PMID: 23506847.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    54. Sustained interleukin-1ß overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci. 2013 Mar 13; 33(11):5053-64. Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, LaFerla FM, Olschowka JA, O'Banion MK. PMID: 23486975.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    55. The bradykinin B1 receptor regulates Aß deposition and neuroinflammation in Tg-SwDI mice. Am J Pathol. 2013 May; 182(5):1740-9. Passos GF, Medeiros R, Cheng D, Vasilevko V, Laferla FM, Cribbs DH. PMID: 23470163.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    56. Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology. Biol Psychiatry. 2013 Sep 01; 74(5):357-66. Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN. PMID: 23312564.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    57. Intracellular accumulation of toxic turn amyloid-ß is associated with endoplasmic reticulum stress in Alzheimer's disease. Curr Alzheimer Res. 2013 Jan; 10(1):11-20. Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T, Murakami K, Irie K, Kinoshita N, LaFerla FM, Kiyohara Y, Iwaki T, Kira J. PMID: 22950910.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    58. Elucidating the triggers, progression, and effects of Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S195-210. Medeiros R, Chabrier MA, LaFerla FM. PMID: 22635105.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    59. Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease. PLoS One. 2012; 7(12):e51432. Chen Y, Tian Z, Liang Z, Sun S, Dai CL, Lee MH, LaFerla FM, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. PMID: 23236499.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    60. Soluble aß promotes wild-type tau pathology in vivo. J Neurosci. 2012 Nov 28; 32(48):17345-50. Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM. PMID: 23197725.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    61. Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice. PLoS One. 2012; 7(11):e48782. Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, Laferla FM, Cai H, Rose GM, Patrylo PR. PMID: 23155407.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    62. Animal models of Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Nov 01; 2(11). LaFerla FM, Green KN. PMID: 23002015.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    63. Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function. Brain Res. 2012 Dec 13; 1489:8-16. Neely Kayala KM, Dickinson GD, Minassian A, Walls KC, Green KN, Laferla FM. PMID: 23103503.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    64. Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. Exp Neurol. 2013 Jan; 239:133-8. Medeiros R, LaFerla FM. PMID: 23063604.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    65. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. PMID: 23062850.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    66. Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging. Acta Neuropathol. 2013 Jan; 125(1):145-57. Solé-Domènech S, Sjövall P, Vukojevic V, Fernando R, Codita A, Salve S, Bogdanovic N, Mohammed AH, Hammarström P, Nilsson KP, LaFerla FM, Jacob S, Berggren PO, Giménez-Llort L, Schalling M, Terenius L, Johansson B. PMID: 22996963.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    67. Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aß(1-42) and tau. Biochem Biophys Res Commun. 2012 Oct 12; 427(1):218-22. Chakravarthy B, Gaudet C, Ménard M, Brown L, Atkinson T, Laferla FM, Ito S, Armato U, Dal Prà I, Whitfield J. PMID: 22995307.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    68. Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease. Learn Mem. 2012 Sep 14; 19(10):453-60. Guzmán-Ramos K, Moreno-Castilla P, Castro-Cruz M, McGaugh JL, Martínez-Coria H, LaFerla FM, Bermúdez-Rattoni F. PMID: 22984283.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    69. Preclinical success against Alzheimer's disease with an old drug. N Engl J Med. 2012 Aug 09; 367(6):570-2. LaFerla FM. PMID: 22873540.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    70. APP knockout mice experience acute mortality as the result of ischemia. PLoS One. 2012; 7(8):e42665. Koike MA, Lin AJ, Pham J, Nguyen E, Yeh JJ, Rahimian R, Tromberg BJ, Choi B, Green KN, LaFerla FM. PMID: 22912719.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    71. Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener. 2012 Aug 06; 7:37. Rasool S, Albay R, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. PMID: 22866920.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    72. Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aß or tau pathology. PLoS One. 2012; 7(8):e39566. Castello NA, Green KN, LaFerla FM. PMID: 22870188.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    73. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem. 2012 Aug 31; 287(36):30317-27. Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, LaFerla FM. PMID: 22753410.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    74. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012 Aug; 181(2):616-25. Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. PMID: 22688056.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    75. Sortilin is required for toxic action of Aß oligomers (AßOs): extracellular AßOs trigger apoptosis, and intraneuronal AßOs impair degradation pathways. Life Sci. 2012 Dec 10; 91(23-24):1177-86. Takamura A, Sato Y, Watabe D, Okamoto Y, Nakata T, Kawarabayashi T, Oddo S, Laferla FM, Shoji M, Matsubara E. PMID: 22579764.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    76. Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-ß and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications. J Am Chem Soc. 2012 May 02; 134(17):7467-79. Alonso E, Fuwa H, Vale C, Suga Y, Goto T, Konno Y, Sasaki M, LaFerla FM, Vieytes MR, Giménez-Llort L, Botana LM. PMID: 22475455.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    77. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr). 2013 Jun; 35(3):519-31. Walker MP, LaFerla FM, Oddo SS, Brewer GJ. PMID: 22237558.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    78. Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr Pharm Des. 2012; 18(8):1131-47. Kitazawa M, Medeiros R, Laferla FM. PMID: 22288400.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    79. Early increases in soluble amyloid-ß levels coincide with cholinergic degeneration in 3xTg-AD mice. J Alzheimers Dis. 2012; 32(2):267-72. Girão da Cruz MT, Jordão J, Dasilva KA, Ayala-Grosso CA, Ypsilanti A, Weng YQ, Laferla FM, McLaurin J, Aubert I. PMID: 22776965.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    80. Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention. J Alzheimers Dis. 2012; 32(1):217-32. Wolf AB, Braden BB, Bimonte-Nelson H, Kusne Y, Young N, Engler-Chiurazzi E, Garcia AN, Walker DG, Moses GS, Tran H, LaFerla F, Lue L, Emerson Lombardo N, Valla J. PMID: 22796872.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    81. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ß-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011 Dec 15; 187(12):6539-49. Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 22095718.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    82. Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiol Aging. 2012 Jun; 33(6):1121.e1-12. Cassano T, Serviddio G, Gaetani S, Romano A, Dipasquale P, Cianci S, Bellanti F, Laconca L, Romano AD, Padalino I, LaFerla FM, Nicoletti F, Cuomo V, Vendemiale G. PMID: 22035587.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    83. 13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aß and hyperphosphorylated tau in vitro. Neurochem Int. 2011 Dec; 59(7):1056-65. Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM. PMID: 21907746.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    84. A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta. 2012 May; 1820(5):553-64. Coskun P, Wyrembak J, Schriner SE, Chen HW, Marciniack C, Laferla F, Wallace DC. PMID: 21871538.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    85. The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides. PLoS One. 2011; 6(7):e22370. Bianchi FT, Camera P, Ala U, Imperiale D, Migheli A, Boda E, Tempia F, Berto G, Bosio Y, Oddo S, LaFerla FM, Taraglio S, Dotti CG, Di Cunto F. PMID: 21829458.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    86. Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimers Dement. 2011 Sep; 7(5):521-531.e1. Tang JX, Mardini F, Caltagarone BM, Garrity ST, Li RQ, Bianchi SL, Gomes O, Laferla FM, Eckenhoff RG, Eckenhoff MF. PMID: 21745760.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    87. BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aß antibody labeling of early-onset axon terminal pathology. Neurotox Res. 2012 Feb; 21(2):160-74. Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX. PMID: 21725719.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    88. Olfactory memory is impaired in a triple transgenic model of Alzheimer disease. Behav Brain Res. 2011 Oct 31; 224(2):408-12. Cassano T, Romano A, Macheda T, Colangeli R, Cimmino CS, Petrella A, LaFerla FM, Cuomo V, Gaetani S. PMID: 21741995.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    89. Animal models of Alzheimer's disease. Int J Alzheimers Dis. 2010; 2010:606357. Casadesus G, Arendash G, Laferla F, McDonald M. PMID: 21804934.
      View in: PubMed   Mentions:
    90. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-ß accumulation and independently accelerates the development of tau abnormalities. J Neurosci. 2011 Jun 29; 31(26):9513-25. Tran HT, LaFerla FM, Holtzman DM, Brody DL. PMID: 21715616.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    91. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011 Aug; 179(2):980-91. Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. PMID: 21704011.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    92. The cholinergic antagonist gymnodimine improves Aß and tau neuropathology in an in vitro model of Alzheimer disease. Cell Physiol Biochem. 2011; 27(6):783-94. Alonso E, Vale C, Vieytes MR, Laferla FM, Giménez-Llort L, Botana LM. PMID: 21691095.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    93. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem. 2011 Jul 08; 286(27):24264-74. Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. PMID: 21606494.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    94. Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol. 2011 Jun; 178(6):2811-22. Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM. PMID: 21531375.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    95. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011 May 09; 495(1):55-9. Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM. PMID: 21419194.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    96. ST101 induces a novel 17 kDa APP cleavage that precludes Aß generation in vivo. Ann Neurol. 2011 May; 69(5):831-44. Green KN, Khashwji H, Estrada T, Laferla FM. PMID: 21416488.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    97. Proflavine derivatives as fluorescent imaging agents of amyloid deposits. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2203-6. Garin D, Oukhatar F, Mahon AB, Try AC, Dubois-Dauphin M, Laferla FM, Demeunynck M, Sallanon MM, Chierici S. PMID: 21435875.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    98. Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner. J Neurosci. 2011 Feb 23; 31(8):2781-91. Neely KM, Green KN, LaFerla FM. PMID: 21414900.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    99. Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer's disease. Ann Biomed Eng. 2011 Apr; 39(4):1349-57. Lin AJ, Koike MA, Green KN, Kim JG, Mazhar A, Rice TB, LaFerla FM, Tromberg BJ. PMID: 21331663.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    100. Apomorphine treatment in Alzheimer mice promoting amyloid-ß degradation. Ann Neurol. 2011 Feb; 69(2):248-56. Himeno E, Ohyagi Y, Ma L, Nakamura N, Miyoshi K, Sakae N, Motomura K, Soejima N, Yamasaki R, Hashimoto T, Tabira T, LaFerla FM, Kira J. PMID: 21387370.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    101. Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease. J Proteomics. 2011 Apr 01; 74(4):466-79. Chou JL, Shenoy DV, Thomas N, Choudhary PK, Laferla FM, Goodman SR, Breen GA. PMID: 21237293.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    102. Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. J Alzheimers Dis. 2011; 24(3):421-54. García-Mesa Y, López-Ramos JC, Giménez-Llort L, Revilla S, Guerra R, Gruart A, Laferla FM, Cristòfol R, Delgado-García JM, Sanfeliu C. PMID: 21297257.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    103. Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17; 5(11):e14015. Parachikova A, Green KN, Hendrix C, LaFerla FM. PMID: 21103342.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    104. Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice. PLoS One. 2010 Nov 16; 5(11):e15477. Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J. PMID: 21103384.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    105. Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice. J Neurosci. 2010 Oct 20; 30(42):13966-76. Piedrahita D, Hernández I, López-Tobón A, Fedorov D, Obara B, Manjunath BS, Boudreau RL, Davidson B, Laferla F, Gallego-Gómez JC, Kosik KS, Cardona-Gómez GP. PMID: 20962218.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    106. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aß and tau pathologies in 3xTg-AD mice. Acta Neuropathol. 2010 Nov; 120(5):605-21. Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I. PMID: 20697724.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    107. Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models. Brain Res. 2010 Aug 06; 1347:179-85. Nicholson RM, Kusne Y, Nowak LA, LaFerla FM, Reiman EM, Valla J. PMID: 20677372.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    108. Pathways linking Abeta and tau pathologies. Biochem Soc Trans. 2010 Aug; 38(4):993-5. LaFerla FM. PMID: 20658991.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    109. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes. Brain Res. 2010 Aug 12; 1348:149-55. Sterniczuk R, Antle MC, Laferla FM, Dyck RH. PMID: 20558146.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    110. The role of tau in Alzheimer's disease and related disorders. CNS Neurosci Ther. 2011 Oct; 17(5):514-24. Medeiros R, Baglietto-Vargas D, LaFerla FM. PMID: 20553310.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    111. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes. Brain Res. 2010 Aug 12; 1348:139-48. Sterniczuk R, Dyck RH, Laferla FM, Antle MC. PMID: 20471965.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    112. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26; 30(21):7281-9. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. PMID: 20505094.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    113. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010 Jul; 177(1):300-10. Koike MA, Green KN, Blurton-Jones M, Laferla FM. PMID: 20472896.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    114. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci. 2010 Apr; 13(4):411-3. Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. PMID: 20305648.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    115. Alzheimer's disease. N Engl J Med. 2010 Jan 28; 362(4):329-44. Querfurth HW, LaFerla FM. PMID: 20107219.
      View in: PubMed   Mentions: 1117     Fields:    Translation:HumansCells
    116. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3081-6. Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. PMID: 20133765.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    117. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One. 2010 Jan 20; 5(1):e8593. Hasegawa T, Mikoda N, Kitazawa M, LaFerla FM. PMID: 20098691.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    118. Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J Alzheimers Dis. 2010; 19(3):915-25. Chakravarthy B, Gaudet C, Ménard M, Atkinson T, Brown L, Laferla FM, Armato U, Whitfield J. PMID: 20157247.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    119. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis. 2010; 21(2):527-42. Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN. PMID: 20555131.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    120. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010 Feb; 176(2):870-80. Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM. PMID: 20042680.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    121. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009 Dec 28; 187(7):1083-99. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. PMID: 20026656.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    122. Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice. Cell Mol Neurobiol. 2010 May; 30(4):577-90. Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM. PMID: 19943189.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    123. Inhaled anesthetic potency in aged Alzheimer mice. Anesth Analg. 2010 Feb 01; 110(2):427-30. Bianchi SL, Caltagarone BM, Laferla FM, Eckenhoff RG, Kelz MB. PMID: 19820240.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    124. Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience. 2009 Dec 15; 164(3):1334-46. Robertson RT, Baratta J, Yu J, LaFerla FM. PMID: 19772895.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    125. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem. 2009 Oct 23; 284(43):29427-36. Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. PMID: 19710014.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    126. Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. Biol Psychiatry. 2010 Mar 15; 67(6):513-21. España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA. PMID: 19664757.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    127. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. PMID: 19633196.
      View in: PubMed   Mentions: 222     Fields:    Translation:AnimalsCells
    128. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15; 183(2):1375-83. Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM, Taylor SM, Woodruff TM, Tenner AJ. PMID: 19561098.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    129. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. Neurochem Int. 2009 Dec; 55(7):476-82. Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. PMID: 19442696.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    130. Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J Neurosci. 2009 May 13; 29(19):6132-41. Kitazawa M, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19439591.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    131. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. J Neurosci Res. 2009 May 01; 87(6):1462-73. Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. PMID: 19021293.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    132. M1 agonists as a potential disease-modifying therapy for Alzheimer's disease. Curr Alzheimer Res. 2009 Apr; 6(2):112-7. Caccamo A, Fisher A, LaFerla FM. PMID: 19355845.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    133. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009 Apr; 34(1):163-77. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. PMID: 19320056.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    134. Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease. Neuropharmacology. 2009 Mar; 56(4):808-13. Bourasset F, Ouellet M, Tremblay C, Julien C, Do TM, Oddo S, LaFerla F, Calon F. PMID: 19705573.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    135. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 2009 Mar; 108(6):1550-60. Kitazawa M, Cheng D, Laferla FM. PMID: 19183260.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    136. Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canines. J Alzheimers Dis. 2009; 16(2):315-23. Nuntagij P, Oddo S, LaFerla FM, Kotchabhakdi N, Ottersen OP, Torp R. PMID: 19221421.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    137. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. J Alzheimers Dis. 2009; 16(3):541-9. Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. PMID: 19276549.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    138. Amyloid-ß protein impairs Ca2+ release and contractility in skeletal muscle. Neurobiol Aging. 2010 Dec; 31(12):2080-90. Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW. PMID: 19108934.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    139. Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology. J Neurosci. 2008 Nov 19; 28(47):12163-75. Oddo S, Caccamo A, Tseng B, Cheng D, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19020010.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    140. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008 Nov 05; 28(45):11500-10. Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. PMID: 18987186.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    141. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. PMID: 18974297.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    142. Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem. 2009 Mar 06; 284(10):6033-7. Morrissette DA, Parachikova A, Green KN, LaFerla FM. PMID: 18948253.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    143. Validation of a 2-day water maze protocol in mice. Behav Brain Res. 2009 Jan 23; 196(2):220-7. Gulinello M, Gertner M, Mendoza G, Schoenfeld BP, Oddo S, LaFerla F, Choi CH, McBride SM, Faber DS. PMID: 18831990.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    144. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease. PLoS One. 2008 Aug 13; 3(8):e2935. Rodríguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A. PMID: 18698410.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimals
    145. Linking calcium to Abeta and Alzheimer's disease. Neuron. 2008 Jul 31; 59(2):190-4. Green KN, LaFerla FM. PMID: 18667147.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    146. Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology. Brain Pathol. 2009 Jul; 19(3):421-30. Oddo S, Caccamo A, Cheng D, LaFerla FM. PMID: 18657136.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    147. Experience-dependent regulation of vesicular zinc in male and female 3xTg-AD mice. Neurobiol Aging. 2010 Apr; 31(4):605-13. Nakashima AS, Oddo S, Laferla FM, Dyck RH. PMID: 18603329.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    148. Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta. Ann Neurol. 2008 Jul; 64(1):15-24. Kitazawa M, Trinh DN, LaFerla FM. PMID: 18318434.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    149. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18591429.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    150. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res. 2008 Jun 24; 1216:92-103. Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y. PMID: 18486110.
      View in: PubMed   Mentions: 89     Fields:    Translation:Animals
    151. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 01; 1207:225-36. McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. PMID: 18374906.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    152. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 2007 Nov 28; 27(48):13357-65. Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ. PMID: 18045930.
      View in: PubMed   Mentions: 122     Fields:    Translation:Animals
    153. Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. J Neurochem. 2008 Apr; 105(1):262-71. Lopez JR, Lyckman A, Oddo S, Laferla FM, Querfurth HW, Shtifman A. PMID: 18021291.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    154. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. PMID: 17978032.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    155. Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration. Eur J Neurosci. 2007 Nov; 26(9):2458-68. Takata K, Hirata-Fukae C, Becker AG, Chishiro S, Gray AJ, Nishitomi K, Franz AH, Sakaguchi G, Kato A, Mattson MP, Laferla FM, Aisen PS, Kitamura Y, Matsuoka Y. PMID: 17970733.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    156. Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem. 2008 Jan; 104(2):457-68. Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW. PMID: 17953662.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    157. Age-related accumulation of Reelin in amyloid-like deposits. Neurobiol Aging. 2009 May; 30(5):697-716. Knuesel I, Nyffeler M, Mormède C, Muhia M, Meyer U, Pietropaolo S, Yee BK, Pryce CR, LaFerla FM, Marighetto A, Feldon J. PMID: 17904250.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    158. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. J Neurochem. 2007 Nov; 103(3):1132-44. Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, Richardson JC, Yan SD, Hanger DP, Allan SM, Sutherland C. PMID: 17683481.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    159. Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci. 2007 Jul; 8(7):499-509. LaFerla FM, Green KN, Oddo S. PMID: 17551515.
      View in: PubMed   Mentions: 496     Fields:    Translation:HumansAnimalsCells
    160. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiol Dis. 2007 Oct; 28(1):76-82. Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, McGaugh JL, LaFerla FM. PMID: 17659878.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    161. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging. 2008 Nov; 29(11):1607-18. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. PMID: 17544172.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    162. Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol. 2007 May; 170(5):1669-75. Caccamo A, Oddo S, Tran LX, LaFerla FM. PMID: 17456772.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    163. Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice. J Neurochem. 2007 Aug; 102(4):1053-63. Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM. PMID: 17472708.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    164. Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. J Neurosci. 2007 Apr 18; 27(16):4385-95. Green KN, Martinez-Coria H, Khashwji H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM. PMID: 17442823.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    165. Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models. Ann N Y Acad Sci. 2007 Feb; 1097:265-77. Stutzmann GE, Smith I, Caccamo A, Oddo S, Parker I, Laferla F. PMID: 17413028.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    166. Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice. J Neurosci. 2007 Jan 24; 27(4):751-61. Billings LM, Green KN, McGaugh JL, LaFerla FM. PMID: 17251414.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    167. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2007 Apr; 26(1):212-20. Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP. PMID: 17306982.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimals
    168. Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci. 2007; 31(2):165-70. Matsuoka Y, Gray AJ, Hirata-Fukae C, Minami SS, Waterhouse EG, Mattson MP, LaFerla FM, Gozes I, Aisen PS. PMID: 17478890.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    169. Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models. Subcell Biochem. 2007; 45:507-21. Green KN, Smith IF, Laferla FM. PMID: 18193650.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    170. Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci. 2006 Dec 20; 26(51):13384-9. Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ. PMID: 17182789.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    171. Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res. 2006 Dec; 3(5):437-48. Blurton-Jones M, Laferla FM. PMID: 17168643.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    172. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006 Dec 22; 281(51):39413-23. Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM. PMID: 17056594.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    173. Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid. Neurosci Biobehav Rev. 2007; 31(1):125-47. Giménez-Llort L, Blázquez G, Cañete T, Johansson B, Oddo S, Tobeña A, LaFerla FM, Fernández-Teruel A. PMID: 17055579.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    174. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 2006 Aug 30; 26(35):9047-56. Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM. PMID: 16943563.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    175. Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology. FASEB J. 2006 Oct; 20(12):2165-7. Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW. PMID: 16940437.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    176. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci. 2006 Jun 14; 26(24):6533-42. Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. PMID: 16775141.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    177. Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol. 2006 Jun; 168(6):1986-97. Kitazawa M, Green KN, Caccamo A, LaFerla FM. PMID: 16723713.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    178. Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci. 2006 May 10; 26(19):5180-9. Stutzmann GE, Smith I, Caccamo A, Oddo S, Laferla FM, Parker I. PMID: 16687509.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    179. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 02; 49(5):671-82. Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. PMID: 16504943.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimals
    180. The role of nicotinic acetylcholine receptors in Alzheimer's disease. J Physiol Paris. 2006 Mar-May; 99(2-3):172-9. Oddo S, LaFerla FM. PMID: 16448808.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    181. A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol. 2006 Jan; 168(1):184-94. Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM. PMID: 16400022.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    182. Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad. Neuron. 2005 Dec 08; 48(5):711-2. LaFerla FM, Kitazawa M. PMID: 16337907.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    183. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006 Jan 20; 281(3):1599-604. Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. PMID: 16282321.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    184. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23. Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. PMID: 16232318.
      View in: PubMed   Mentions: 76     Fields:    
    185. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Sep 28; 25(39):8843-53. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. PMID: 16192374.
      View in: PubMed   Mentions: 222     Fields:    Translation:AnimalsCells
    186. Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. Cell Calcium. 2005 Sep-Oct; 38(3-4):427-37. Smith IF, Green KN, LaFerla FM. PMID: 16125228.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    187. Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem. 2005 Sep; 94(6):1711-8. Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM. PMID: 16156741.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    188. An array of genes implicated in Alzheimer's disease. Neurobiol Aging. 2006 Aug; 27(8):1078-80. LaFerla FM. PMID: 16112251.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    189. Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model. Neurobiol Aging. 2006 Mar; 27(3):423-32. Sugarman MC, Kitazawa M, Baker M, Caiozzo VJ, Querfurth HW, LaFerla FM. PMID: 15950323.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    190. Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May; 26(5):645-54. Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. PMID: 15708439.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    191. Alzheimer's disease: Abeta, tau and synaptic dysfunction. Trends Mol Med. 2005 Apr; 11(4):170-6. LaFerla FM, Oddo S. PMID: 15823755.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    192. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron. 2005 Mar 03; 45(5):675-88. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. PMID: 15748844.
      View in: PubMed   Mentions: 361     Fields:    Translation:AnimalsCells
    193. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):3046-51. Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, LaFerla FM. PMID: 15705720.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    194. Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann N Y Acad Sci. 2004 Dec; 1035:85-103. Kitazawa M, Yamasaki TR, LaFerla FM. PMID: 15681802.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    195. Amyloid beta-peptide: the inside story. Curr Alzheimer Res. 2004 Nov; 1(4):231-9. Tseng BP, Kitazawa M, LaFerla FM. PMID: 15975052.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    196. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1145-52. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PMID: 15336962.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    197. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron. 2004 Aug 05; 43(3):321-32. Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. PMID: 15294141.
      View in: PubMed   Mentions: 257     Fields:    Translation:AnimalsCells
    198. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    199. Live discussion: how the other half lives - or the what, how, and where, of the AbetaPP intracellular domain. J Alzheimers Dis. 2004 Apr; 6(2):193-9. Bishop G, Coleman P, Crutcher K, David D, Kinoshita J, LaFerla F, Leissring M, Shepherd J, Therianos S, Wang R, Wilson A, Zhu M. PMID: 15171221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    200. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004 Feb; 113(4):582-90. Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. PMID: 14966567.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    201. Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability. J Neurosci. 2004 Jan 14; 24(2):508-13. Stutzmann GE, Caccamo A, LaFerla FM, Parker I. PMID: 14724250.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    202. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003 Dec; 24(8):1063-70. Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. PMID: 14643377.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansAnimalsCells
    203. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PMID: 12895417.
      View in: PubMed   Mentions: 1157     Fields:    Translation:HumansAnimalsCells
    204. Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate. J Neurosci. 2003 Feb 01; 23(3):758-65. Stutzmann GE, LaFerla FM, Parker I. PMID: 12574404.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    205. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci. 2002 Nov; 3(11):862-72. LaFerla FM. PMID: 12415294.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimalsCells
    206. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6334-9. Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. PMID: 11972038.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    207. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4697-702. Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. PMID: 11917117.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    208. Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling. Nat Biotechnol. 2001 Jul; 19(7):645-9. Marchant JS, Stutzmann GE, Leissring MA, LaFerla FM, Parker I. PMID: 11433276.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    209. Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling. Neurobiol Dis. 2001 Jun; 8(3):469-78. Leissring MA, LaFerla FM, Callamaras N, Parker I. PMID: 11442355.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    210. Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-gamma. J Mol Neurosci. 2000 Aug; 15(1):45-59. LaFerla FM, Sugarman MC, Lane TE, Leissring MA. PMID: 11211236.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    211. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8590-3. Leissring MA, Yamasaki TR, Wasco W, Buxbaum JD, Parker I, LaFerla FM. PMID: 10900016.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    212. Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. Biochemistry. 2000 May 23; 39(20):5988-94. Cribbs DH, Azizeh BY, Cotman CW, LaFerla FM. PMID: 10821670.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    213. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol. 2000 May 15; 149(4):793-8. Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. PMID: 10811821.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    214. Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2000 May; 23(5):222-9. Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD. PMID: 10782128.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    215. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals. J Biol Chem. 1999 Nov 12; 274(46):32535-8. Leissring MA, Parker I, LaFerla FM. PMID: 10551803.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    216. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999 Mar; 72(3):1061-8. Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. PMID: 10037477.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    217. Herpes simplex virus infections and Alzheimer's disease. Implications for drug treatment and immunotherapy. Drugs Aging. 1998 Sep; 13(3):193-8. Leissring MA, Sugarman MC, LaFerla FM. PMID: 9789723.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    218. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest. 1997 Jul 15; 100(2):310-20. LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G. PMID: 9218507.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    219. Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Exp Neurol. 1997 Jan; 143(1):37-44. Weber LL, Leissring MA, Yang AJ, Glabe CG, Cribbs DH, LaFerla FM. PMID: 9000444.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    220. Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest. 1996 Oct 01; 98(7):1626-32. LaFerla FM, Hall CK, Ngo L, Jay G. PMID: 8833912.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    221. Injury induces presenilin-1 gene expression in mouse brain. Neuroreport. 1996 Jul 29; 7(11):1773-6. Cribbs DH, Chen LS, Cotman CW, LaFerla FM. PMID: 8905662.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    222. Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. Am J Pathol. 1996 Jun; 148(6):1797-806. Cribbs DH, Chen LS, Bende SM, LaFerla FM. PMID: 8669467.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    223. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet. 1995 Jan; 9(1):21-30. LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G. PMID: 7704018.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    Frank's Networks
    Concepts (777)
    Derived automatically from this person's publications.
    _
    Co-Authors (52)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _