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Mapstone, Mark E

TitleHealth Sciences Professor
InstitutionUniversity of California, Irvine
DepartmentNeurology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7184
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    Collapse Research 
    Collapse Research Activities and Funding
    Multi-omic Investigation of Exercise Effects in Mild Cognitive Impairment
    NIH/NIA R01AG058644Jul 1, 2018 - Feb 28, 2022
    Role: Principal Investigator
    Attention and Memory Influences on Navigation in Alzheimer's Disease
    NIH/NIA K23AG020647Feb 15, 2003 - Jan 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury. Metabolites. 2018 Sep 07; 8(3). PMID: 30205491.
      View in: PubMed
    2. Gross T, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS. Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-Processing and a Basis for Analytic Pipeline Development. Curr Top Med Chem. 2018 Jul 11. PMID: 29992885.
      View in: PubMed
    3. Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ. Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018; 13(4):e0195318. PMID: 29677216.
      View in: PubMed
    4. Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S. Precision pharmacology for Alzheimer's disease. Pharmacol Res. 2018 Apr; 130:331-365. PMID: 29458203.
      View in: PubMed
    5. Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki ES, Malik S, Macciardi F, Federoff HJ. Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017 Dec 19; 11(1):142. PMID: 29258513.
      View in: PubMed
    6. Wang X, Ren P, Baran TM, Raizada RDS, Mapstone M, Lin F. Longitudinal Functional Brain Mapping in Supernormals. Cereb Cortex. 2017 Nov 23; 1-11. PMID: 29186360.
      View in: PubMed
    7. Wang X, Ren P, Mapstone M, Conwell Y, Porsteinsson AP, Foxe JJ, Raizada RDS, Lin F. Identify a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer's pathology. Brain Imaging Behav. 2017 Sep 15. PMID: 28913718.
      View in: PubMed
    8. Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, Cheema AK. Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget. 2017 Sep 15; 8(40):68899-68915. PMID: 28978166.
      View in: PubMed
    9. Zhuang Y, Qiu X, Wang L, Ma Q, Mapstone M, Luque A, Weber M, Tivarus M, Miller E, Arduino RC, Zhong J, Schifitto G. Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naïve HIV-infected individuals. J Neurovirol. 2017 Oct; 23(5):704-712. PMID: 28791662.
      View in: PubMed
    10. Chapman BP, Benedict RHB, Lin F, Roy S, Porteinsson A, Szigeti K, Federoff H, Mapstone M. Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype. Int J Geriatr Psychiatry. 2018 Feb; 33(2):332-339. PMID: 28612377.
      View in: PubMed
    11. Grill JD, Apostolova LG, Bullain S, Burns JM, Cox CG, Dick M, Hartley D, Kawas C, Kremen S, Lingler J, Lopez OL, Mapstone M, Pierce A, Rabinovici G, Roberts JS, Sajjadi SA, Teng E, Karlawish J. Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther. 2017 May 04; 9(1):35. PMID: 28472970.
      View in: PubMed
    12. Chapman BP, Benedict RH, Lin F, Roy S, Federoff HJ, Mapstone M. Personality and Performance in Specific Neurocognitive Domains Among Older Persons. Am J Geriatr Psychiatry. 2017 Aug; 25(8):900-908. PMID: 28456386.
      View in: PubMed
    13. Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff HJ. Biomarker validation: Methods and matrix matter. Alzheimers Dement. 2017 05; 13(5):608-609. PMID: 28010950.
      View in: PubMed
    14. Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 Mar; 51:148-155. PMID: 27939698.
      View in: PubMed
    15. Lin F, Ren P, Mapstone M, Meyers SP, Porsteinsson A, Baran TM. The cingulate cortex of older adults with excellent memory capacity. Cortex. 2017 01; 86:83-92. PMID: 27930899.
      View in: PubMed
    16. Ren P, Lo RY, Chapman BP, Mapstone M, Porsteinsson A, Lin F. Longitudinal Alteration of Intrinsic Brain Activity in the Striatum in Mild Cognitive Impairment. J Alzheimers Dis. 2016 07 25; 54(1):69-78. PMID: 27472880; PMCID: PMC5003682.
    17. Lin F, Heffner KL, Ren P, Tivarus ME, Brasch J, Chen DG, Mapstone M, Porsteinsson AP, Tadin D. Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study. J Am Geriatr Soc. 2016 Jun; 64(6):1293-8. PMID: 27321608; PMCID: PMC4916855 [Available on 06/01/17].
    18. Wasserman EB, Bazarian JJ, Mapstone M, Block R, van Wijngaarden E. Academic Dysfunction After a Concussion Among US High School and College Students. Am J Public Health. 2016 Jul; 106(7):1247-53. PMID: 27196651.
      View in: PubMed
    19. Chapman RM, Gardner MN, Mapstone M, Klorman R, Porsteinsson AP, Dupree HM, Antonsdottir IM, Kamalyan L. ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do. Clin Neurophysiol. 2016 06; 127(6):2423-35. PMID: 27178862; PMCID: PMC4959798 [Available on 06/01/17].
    20. Lin F, Ren P, Cotton K, Porsteinsson A, Mapstone M, Heffner KL. Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2016 May; 24(5):374-8. PMID: 26905050; PMCID: PMC4846469 [Available on 05/01/17].
    21. Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Front Neurol. 2015; 6:237. PMID: 26617567; PMCID: PMC4642213.
    22. Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 2015 Oct; 14(10):1002-9. PMID: 26271532.
      View in: PubMed
    23. Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff HJ, Newport EL. Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci. 2015; 9:231. PMID: 25972803; PMCID: PMC4413691.
    24. Chapman RM, Gardner MN, Mapstone M, Dupree HM, Antonsdottir IM. Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage. Brain Res. 2015 Apr 16; 1604:74-83. PMID: 25641043; PMCID: PMC4524323.
    25. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1. PMID: 25130657.
      View in: PubMed
    26. Lin F, Lo RY, Cole D, Ducharme S, Chen DG, Mapstone M, Porsteinsson A. Longitudinal effects of metabolic syndrome on Alzheimer and vascular related brain pathology. Dement Geriatr Cogn Dis Extra. 2014 May; 4(2):184-94. PMID: 25337075; PMCID: PMC4187257.
    27. Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S196-212. PMID: 24924671.
      View in: PubMed
    28. Lin F, Roiland R, Heffner K, Johnson M, Chen DG, Mapstone M. Evaluation of objective and perceived mental fatigability in older adults with vascular risk. J Psychosom Res. 2014 Jun; 76(6):458-64. PMID: 24840140; PMCID: PMC4033905.
    29. Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr; 20(4):415-8. PMID: 24608097.
      View in: PubMed
    30. Lin F, Roiland R, Polesskaya O, Chapman B, Johnson M, Brasch J, Chen DG, Mapstone M. Fatigability disrupts cognitive processes' regulation of inflammatory reactivity in old age. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1544-54. PMID: 24388221; PMCID: PMC4048650.
    31. Chapman RM, Porsteinsson AP, Gardner MN, Mapstone M, McCrary JW, Sandoval TC, Guillily MD, Reilly LA, DeGrush E. The impact of AD drug treatments on event-related potentials as markers of disease conversion. Curr Alzheimer Res. 2013 Sep; 10(7):732-41. PMID: 23905997; PMCID: PMC4021490.
    32. Mapstone M, Hilton TN, Yang H, Guido JJ, Luque AE, Hall WJ, Dewhurst S, Shah K. Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging Dis. 2013; 4(6):311-9. PMID: 24307964; PMCID: PMC3843648.
    33. Lin F, Heffner K, Mapstone M, Chen DG, Porsteisson A. Frequency of mentally stimulating activities modifies the relationship between cardiovascular reactivity and executive function in old age. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1210-21. PMID: 23891367; PMCID: PMC3900591.
    34. Reginold W, Duff-Canning S, Meaney C, Armstrong MJ, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger P, Marshall F, Mapstone M, Chou KL, Persad C, Litvan I, Mast B, Tang-Wai D, Lang AE, Marras C. Impact of mild cognitive impairment on health-related quality of life in Parkinson's disease. Dement Geriatr Cogn Disord. 2013; 36(1-2):67-75. PMID: 23774742.
      View in: PubMed
    35. Marras C, Armstrong MJ, Meaney CA, Fox S, Rothberg B, Reginold W, Tang-Wai DF, Gill D, Eslinger PJ, Zadikoff C, Kennedy N, Marshall FJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Gerstenecker AT, Weintraub S, Duff-Canning S. Measuring mild cognitive impairment in patients with Parkinson's disease. Mov Disord. 2013 May; 28(5):626-33. PMID: 23520128; PMCID: PMC4524474.
    36. Chapman RM, Porsteinsson AP, Gardner MN, Mapstone M, McCrary JW, Sandoval TC, Guillily MD, DeGrush E, Reilly LA. C145 as a short-latency electrophysiological index of cognitive compensation in Alzheimer's disease. J Alzheimers Dis. 2013; 33(1):55-68. PMID: 22886016; PMCID: PMC3576817.
    37. Selzler K, Burack M, Bender R, Mapstone M. Neurophysiological correlates of motor and working memory performance following subthalamic nucleus stimulation. J Cogn Neurosci. 2013 Jan; 25(1):37-48. PMID: 23198889.
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    38. Dar-Nimrod I, Chapman BP, Franks P, Robbins J, Porsteinsson A, Mapstone M, Duberstein PR. Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. Am J Geriatr Psychiatry. 2012 Dec; 20(12):1026-35. PMID: 23079898; PMCID: PMC4184145.
    39. Lin F, Chen DG, Vance DE, Ball KK, Mapstone M. Longitudinal relationships between subjective fatigue, cognitive function, and everyday functioning in old age. Int Psychogeriatr. 2013 Feb; 25(2):275-85. PMID: 23083533; PMCID: PMC3552486.
    40. Armstrong MJ, Duff-Canning S, Tang-Wai DF, Fox S, Zadikoff C, Kennedy N, Gill D, Eslinger PJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Marras C. The meaning of a "hippo" response on the Montreal Cognitive Assessment in Parkinson's disease. Parkinsonism Relat Disord. 2013 Apr; 19(4):463-5. PMID: 23036511.
      View in: PubMed
    41. Lin F, Chen DG, Vance D, Mapstone M. Trajectories of combined laboratory- and real world-based speed of processing in community-dwelling older adults. J Gerontol B Psychol Sci Soc Sci. 2013 May; 68(3):364-73. PMID: 22967505; PMCID: PMC3627655.
    42. Reginold W, Armstrong MJ, Duff-Canning S, Lang A, Tang-Wai D, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger P, Mapstone M, Chou K, Persad C, Litvan I, Mast B, Marras C. The pill questionnaire in a nondemented Parkinson's disease population. Mov Disord. 2012 Sep 01; 27(10):1308-11. PMID: 22865587.
      View in: PubMed
    43. Weber MT, Mapstone M, Staskiewicz J, Maki PM. Reconciling subjective memory complaints with objective memory performance in the menopausal transition. Menopause. 2012 Jul; 19(7):735-41. PMID: 22415562; PMCID: PMC3773730.
    44. Lin F, Friedman E, Quinn J, Chen DG, Mapstone M. Effect of leisure activities on inflammation and cognitive function in an aging sample. Arch Gerontol Geriatr. 2012 May-Jun; 54(3):e398-404. PMID: 22377120; PMCID: PMC3331938.
    45. Dar-Nimrod I, Chapman BP, Robbins JA, Porsteinsson A, Mapstone M, Duberstein PR. Gene by neuroticism interaction and cognitive function among older adults. Int J Geriatr Psychiatry. 2012 Nov; 27(11):1147-54. PMID: 23042108; PMCID: PMC3466473.
    46. Chapman RM, Mapstone M, Gardner MN, Sandoval TC, McCrary JW, Guillily MD, Reilly LA, DeGrush E. Women have farther to fall: gender differences between normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women. J Int Neuropsychol Soc. 2011 Jul; 17(4):654-62. PMID: 21486518; PMCID: PMC3387297.
    47. Chapman RM, Mapstone M, Porsteinsson AP, Gardner MN, McCrary JW, DeGrush E, Reilly LA, Sandoval TC, Guillily MD. Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses. J Clin Exp Neuropsychol. 2010 Oct; 32(8):793-808. PMID: 20358452; PMCID: PMC2896992.
    48. Chapman RM, Mapstone M, McCrary JW, Gardner MN, Porsteinsson A, Sandoval TC, Guillily MD, Degrush E, Reilly LA. Predicting conversion from mild cognitive impairment to Alzheimer's disease using neuropsychological tests and multivariate methods. J Clin Exp Neuropsychol. 2011 Feb; 33(2):187-99. PMID: 20711906; PMCID: PMC3048956.
    49. Mapstone M, Duffy CJ. Approaching objects cause confusion in patients with Alzheimer's disease regarding their direction of self-movement. Brain. 2010 Sep; 133(9):2690-701. PMID: 20647265; PMCID: PMC2948814.
    50. Chapman RM, Mapstone M, McCrary JW, Gardner MN, Bachus LE, Degrush E, Reilly LA, Sandoval TC, Guillily MD. Cognitive Dimensions in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Elderly: Developing a Common Metric. Open Geriatr Med J. 2010 Jan 28; 3(10):1-10. PMID: 20717503.
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    51. Weber M, Mapstone M. Memory complaints and memory performance in the menopausal transition. Menopause. 2009 Jul-Aug; 16(4):694-700. PMID: 19276998.
      View in: PubMed
    52. Kohli S, Fisher SG, Tra Y, Adams MJ, Mapstone ME, Wesnes KA, Roscoe JA, Morrow GR. The effect of modafinil on cognitive function in breast cancer survivors. Cancer. 2009 Jun 15; 115(12):2605-16. PMID: 19309747; PMCID: PMC2796482.
    53. Mapstone M, Dickerson K, Duffy CJ. Distinct mechanisms of impairment in cognitive ageing and Alzheimer's disease. Brain. 2008 Jun; 131(Pt 6):1618-29. PMID: 18385184.
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    54. Mapstone M, Logan D, Duffy CJ. Cue integration for the perception and control of self-movement in ageing and Alzheimer's disease. Brain. 2006 Nov; 129(Pt 11):2931-44. PMID: 17071922.
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    55. Tang-Wai D, Mapstone M. What are we seeing? Is posterior cortical atrophy just Alzheimer disease? Neurology. 2006 Feb 14; 66(3):300-1. PMID: 16476924.
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    56. Smith WS, Mapstone M. Does extracorporeal circulation harm the brain? Neurology. 2005 Oct 11; 65(7):978-9. PMID: 16217045.
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    57. Rösler A, Mapstone M, Hays-Wicklund A, Gitelman DR, Weintraub S. The "zoom lens" of focal attention in visual search: changes in aging and Alzheimer's disease. Cortex. 2005 Aug; 41(4):512-9. PMID: 16042027.
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    58. Mapstone M, Steffenella TM, Duffy CJ. A visuospatial variant of mild cognitive impairment: getting lost between aging and AD. Neurology. 2003 Mar 11; 60(5):802-8. PMID: 12629237.
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    59. Mapstone M, Weintraub S, Nowinski C, Kaptanoglu G, Gitelman DR, Mesulam MM. Cerebral hemispheric specialization for spatial attention: spatial distribution of search-related eye fixations in the absence of neglect. Neuropsychologia. 2003; 41(10):1396-409. PMID: 12757911.
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    60. Rösler A, Mapstone ME, Hays AK, Mesulam MM, Rademaker A, Gitelman DR, Weintraub S. Alterations of visual search strategy in Alzheimer's disease and aging. Neuropsychology. 2000 Jul; 14(3):398-408. PMID: 10928743.
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