Jonathan Robert Todd Lakey

Title(s)Professor Emeritus, Surgery
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8022
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    1. Exosomes; a Potential Source of Biomarkers, Therapy, and Cure for Type-1 Diabetes. Int J Mol Sci. 2023 Oct 28; 24(21). Lakey JRT, Wang Y, Alexander M, Chan MKS, Wong MBF, Casazza K, Jenkins I. PMID: 37958696; PMCID: PMC10647572.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Stem Cell Therapy for Aging Related Diseases and Joint Diseases in Companion Animals. Animals (Basel). 2023 Jul 29; 13(15). Wang Y, Alexander M, Scott T, Cox DCT, Wellington A, Chan MKS, Wong MBF, Adalsteinsson O, Lakey JRT. PMID: 37570266; PMCID: PMC10417747.
      View in: PubMed   Mentions:
    3. A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization's Role as a Treatment Modality. Int J Mol Sci. 2023 Jun 30; 24(13). Lewis ST, Greenway F, Tucker TR, Alexander M, Jackson LK, Hepford SA, Loveridge B, Lakey JRT. PMID: 37446104; PMCID: PMC10341609.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials. Polymers (Basel). 2023 Mar 06; 15(5). Eslami-Kaliji F, Hedayat Nia N, Lakey JRT, Smink AM, Mohammadi M. PMID: 36904554; PMCID: PMC10007405.
      View in: PubMed   Mentions: 1  
    5. Monitoring of Autoantibodies Following Autologous Hematopoietic Stem Cell Transplantation in 6 Children with Recently Diagnosed Type 1 Diabetes Mellitus. Med Sci Monit. 2023 Jan 20; 29:e938979. Mesples AD, Cox DCT, Lundy HD, Antonio-Collie S, Diggiss CW, Lakey JRT. PMID: 36659834; PMCID: PMC9872439.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Successful Islet Transplantation Into a Subcutaneous Polycaprolactone Scaffold in Mice and Pigs. Transplant Direct. 2023 Jan; 9(1):e1417. Smink AM, Rodriquez S, Li S, Ceballos B, Corrales N, Alexander M, Koster T, de Haan BJ, Lakey JRT, de Vos P. PMID: 36591328; PMCID: PMC9788983.
      View in: PubMed   Mentions:
    7. Anti-Oxidative Therapy in Islet Cell Transplantation. Antioxidants (Basel). 2022 May 24; 11(6). Eguchi N, Damyar K, Alexander M, Dafoe D, Lakey JRT, Ichii H. PMID: 35739935; PMCID: PMC9219662.
      View in: PubMed   Mentions: 1  
    8. Inclusion of extracellular matrix molecules and necrostatin-1 in the intracapsular environment of alginate-based microcapsules synergistically protects pancreatic β cells against cytokine-induced inflammatory stress. Acta Biomater. 2022 07 01; 146:434-449. Qin T, Hu S, Smink AM, de Haan BJ, Silva-Lagos LA, Lakey JRT, de Vos P. PMID: 35500812.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Physiologic Insulin Resensitization as a Treatment Modality for Insulin Resistance Pathophysiology. Int J Mol Sci. 2022 Feb 08; 23(3). Greenway F, Loveridge B, Grimes RM, Tucker TR, Alexander M, Hepford SA, Fontenot J, Nobles-James C, Wilson C, Starr AM, Abdelsaid M, Lewis ST, Lakey JRT. PMID: 35163806; PMCID: PMC8836751.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Exploring Insulin Production Following Alveolar Islet Transplantation (AIT). Int J Mol Sci. 2021 Sep 22; 22(19). Lau H, Khosrawipour T, Li S, Alexander M, Frelkiewicz P, Labbé MK, Stieglitz S, Lakey JRT, Kielan W, Khosrawipour V. PMID: 34638521; PMCID: PMC8508311.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. An overview of current advancements in pancreatic islet transplantation into the omentum. Islets. 2021 09 03; 13(5-6):115-120. Damyar K, Farahmand V, Whaley D, Alexander M, Lakey JRT. PMID: 34402725; PMCID: PMC8528405.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Comparison of islet isolation result and clinical applicability according to GMP-grade collagenase enzyme blend in adult porcine islet isolation and culture. Xenotransplantation. 2021 07; 28(4):e12703. Kwak K, Park JK, Shim J, Ko N, Kim HJ, Lee Y, Kim JH, Alexander M, Lakey JRT, Kim H, Choi K. PMID: 34176167; PMCID: PMC8459292.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    13. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 06 03; 4(1):685. Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. PMID: 34083739; PMCID: PMC8175379.
      View in: PubMed   Mentions: 16  Translation:HumansAnimalsCells
    14. Applying Immunomodulation to Promote Longevity of Immunoisolated Pancreatic Islet Grafts. Tissue Eng Part B Rev. 2022 02; 28(1):129-140. Kuwabara R, Hu S, Smink AM, Orive G, Lakey JRT, de Vos P. PMID: 33397201.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. The effects of necrostatin-1 on the in vitro development and function of young porcine islets over 14-day prolonged tissue culture. Xenotransplantation. 2021 05; 28(3):e12667. Lau H, Corrales N, Rodriguez S, Park S, Mohammadi M, Li S, Alexander M, Lakey JRT. PMID: 33438288.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. Dose-dependent effects of necrostatin-1 supplementation to tissue culture media of young porcine islets. PLoS One. 2020; 15(12):e0243506. Lau H, Corrales N, Rodriguez S, Luong C, Mohammadi M, Khosrawipour V, Li S, Alexander M, de Vos P, Lakey JRT. PMID: 33284818; PMCID: PMC7721208.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival. Biomaterials. 2021 01; 266:120460. Hu S, Kuwabara R, Navarro Chica CE, Smink AM, Koster T, Medina JD, de Haan BJ, Beukema M, Lakey JRT, García AJ, de Vos P. PMID: 33099059.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    18. In Quest of Pathognomonic/Endophenotypic Markers of Attention Deficit Hyperactivity Disorder (ADHD): Potential of EEG-Based Frequency Analysis and ERPs to Better Detect, Prevent and Manage ADHD. Med Devices (Auckl). 2020; 13:115-137. Miranda P, Cox CD, Alexander M, Danev S, Lakey JRT. PMID: 32547262; PMCID: PMC7250294.
      View in: PubMed   Mentions: 2  
    19. Controlled Release of Stem Cell Secretome Attenuates Inflammatory Response against Implanted Biomaterials. Adv Healthc Mater. 2020 06; 9(12):e1901874. Mohammadi M, Luong JC, Rodriguez SM, Cao R, Wheeler AE, Lau H, Li S, Shabestari SK, Chadarevian JP, Alexander M, de Vos P, Zhao W, Lakey JRT. PMID: 32419390.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. The Effect of a Fast-Releasing Hydrogen Sulfide Donor on Vascularization of Subcutaneous Scaffolds in Immunocompetent and Immunocompromised Mice. Biomolecules. 2020 05 06; 10(5). Smink AM, Najdahmadi A, Alexander M, Li S, Rodriquez S, van Goor H, Hillebrands JL, Botvinick E, Lakey JRT, Vos P. PMID: 32384680; PMCID: PMC7277536.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. An islet maturation media to improve the development of young porcine islets during in vitro culture. Islets. 2020 05 03; 12(3):41-58. Lau H, Corrales N, Rodriguez S, Luong C, Zaldivar F, Alexander M, Lakey JRT. PMID: 32459554; PMCID: PMC7527017.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine Islets. Adv Healthc Mater. 2020 05; 9(9):e2000102. Medina JD, Alexander M, Hunckler MD, Fernández-Yagüe MA, Coronel MM, Smink AM, Lakey JR, de Vos P, García AJ. PMID: 32255552; PMCID: PMC7598935.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Non-Invasive Monitoring of Oxygen Tension and Oxygen Transport Inside Subcutaneous Devices After H2S Treatment. Cell Transplant. 2020 Jan-Dec; 29:963689719893936. Najdahmadi A, Smink AM, de Vos P, Lakey JRT, Botvinick E. PMID: 32024377; PMCID: PMC7444232.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    24. Optimal Time to Ship Human Islets Post Tissue Culture to Maximize Islet. Cell Transplant. 2020 Jan-Dec; 29:963689720974582. Olack BJ, Alexander M, Swanson CJ, Kilburn J, Corrales N, Flores A, Heng J, Arulmoli J, Omori K, Chlebeck PJ, Zitur L, Salgado M, Lakey JRT, Niland JC. PMID: 33231091; PMCID: PMC7885128.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Islet Transplantation in the Lung via Endoscopic Aerosolization: Investigation of Feasibility, Islet Cluster Cell Vitality, and Structural Integrity. Cell Transplant. 2020 Jan-Dec; 29:963689720949244. Lau H, Khosrawipour T, Alexander M, Li S, Mikolajczyk A, Nicpon J, Schubert J, Bania J, Lakey JRT, Khosrawipour V. PMID: 32967455; PMCID: PMC7784503.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    26. Micro/nanobubbles: Improving Pancreatic Islet Cell Survival for Transplantation. Ann Plast Surg. 2019 11; 83(5):583-588. Sayadi LR, Alexander M, Sorensen AM, Sarantopoulos N, Lau H, Klopfer M, Ziegler ME, Banyard DA, Evans GRD, Lakey JRT, Widgerow AD. PMID: 31232817.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Necrostatin-1 supplementation enhances young porcine islet maturation and in vitro function. Xenotransplantation. 2020 01; 27(1):e12555. Lau H, Corrales N, Alexander M, Mohammadi MR, Li S, Smink AM, de Vos P, Lakey JRT. PMID: 31532037.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. Characterization of chelator-mediated recovery of pancreatic islets from barium-stabilized alginate microcapsules. Xenotransplantation. 2020 01; 27(1):e12554. Rodriguez S, Lau H, Corrales N, Heng J, Lee S, Stiner R, Alexander M, Lakey JRT. PMID: 31495985.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    29. Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction. Mol Nutr Food Res. 2019 11; 63(21):e1900307. Wu C, Pan LL, Luo Y, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Yang G, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J. PMID: 31423661.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    30. Efficacy of Periodic Intensive Insulin Therapy on secondary complications of diabetes warrants larger prospective randomized clinical trials. Curr Ther Res Clin Exp. 2019; 91:23. Lakey J. PMID: 31871503; PMCID: PMC6911911.
      View in: PubMed   Mentions:    Fields:    
    31. Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice. Front Immunol. 2019; 10:1733. Wu C, Pan LL, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J. PMID: 31417546; PMCID: PMC6682655.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    32. Biohybrid Nanoparticles to Negotiate with Biological Barriers. Small. 2019 08; 15(34):e1902333. Mohammadi MR, Corbo C, Molinaro R, Lakey JRT. PMID: 31250985.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes. Cell Tissue Res. 2019 Nov; 378(2):155-162. Stiner R, Alexander M, Liu G, Liao W, Liu Y, Yu J, Pone EJ, Zhao W, Lakey JRT. PMID: 31209568.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders. ACS Nano. 2019 06 25; 13(6):6670-6688. Riazifar M, Mohammadi MR, Pone EJ, Yeri A, Lässer C, Segaliny AI, McIntyre LL, Shelke GV, Hutchins E, Hamamoto A, Calle EN, Crescitelli R, Liao W, Pham V, Yin Y, Jayaraman J, Lakey JRT, Walsh CM, Van Keuren-Jensen K, Lotvall J, Zhao W. PMID: 31117376; PMCID: PMC6880946.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    35. Cost and Scalability Analysis of Porcine Islet Isolation for Islet Transplantation: Comparison of Juvenile, Neonatal and Adult Pigs. Cell Transplant. 2019 07; 28(7):967-972. Vanderschelden R, Sathialingam M, Alexander M, Lakey JRT. PMID: 31037984; PMCID: PMC6719497.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    36. Effects of Periodic Intensive Insulin Therapy: An Updated Review. Curr Ther Res Clin Exp. 2019; 90:61-67. Dong S, Lau H, Chavarria C, Alexander M, Cimler A, Elliott JP, Escovar S, Lewin J, Novak J, Lakey JRT. PMID: 31193369; PMCID: PMC6527898.
      View in: PubMed   Mentions: 9     Fields:    
    37. Mathematical predictions of oxygen availability in micro- and macro-encapsulated human and porcine pancreatic islets. J Biomed Mater Res B Appl Biomater. 2020 02; 108(2):343-352. Cao R, Avgoustiniatos E, Papas K, de Vos P, Lakey JRT. PMID: 31013399.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    38. Preliminary Studies of the Impact of CXCL12 on the Foreign Body Reaction to Pancreatic Islets Microencapsulated in Alginate in Nonhuman Primates. Transplant Direct. 2019 May; 5(5):e447. Sremac M, Lei J, Penson MFE, Schuetz C, Lakey JRT, Papas KK, Varde PS, Hering B, de Vos P, Brauns T, Markmann J, Poznansky MC. PMID: 31165082; PMCID: PMC6511446.
      View in: PubMed   Mentions: 8  
    39. Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide-field imaging and conventional immunohistochemistry assays. Int Wound J. 2019 Feb; 16(1):144-152. Saidian M, Lakey JRT, Ponticorvo A, Rowland R, Baldado M, Williams J, Pronda M, Alexander M, Flores A, Shiri L, Zhang S, Choi B, Kohen R, Tromberg BJ, Durkin AJ. PMID: 30273979; PMCID: PMC6329645.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    40. Cytokines as therapeutic agents and targets in heart disease. Cytokine Growth Factor Rev. 2018 10; 43:54-68. Dubnika A, Manoukian MAC, Mohammadi MR, Parekh MB, Gurjarpadhye AA, Inayathullah M, Dubniks V, Lakey JRT, Rajadas J. PMID: 30170892.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    41. In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes. Xenotransplantation. 2018 11; 25(6):e12432. Smith KE, Purvis WG, Davis MA, Min CG, Cooksey AM, Weber CS, Jandova J, Price ND, Molano DS, Stanton JB, Kelly AC, Steyn LV, Lynch RM, Limesand SW, Alexander M, Lakey JRT, Seeberger K, Korbutt GS, Mueller KR, Hering BJ, McCarthy FM, Papas KK. PMID: 30052287.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    42. Polymer scaffolds for pancreatic islet transplantation - Progress and challenges. Am J Transplant. 2018 09; 18(9):2113-2119. Smink AM, de Haan BJ, Lakey JRT, de Vos P. PMID: 29790274.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    43. Approaches in Immunotherapy, Regenerative Medicine, and Bioengineering for Type 1 Diabetes. Front Immunol. 2018; 9:1354. Kopan C, Tucker T, Alexander M, Mohammadi MR, Pone EJ, Lakey JRT. PMID: 29963051; PMCID: PMC6011033.
      View in: PubMed   Mentions: 7     Fields:    
    44. Systematic review of islet cryopreservation. Islets. 2018 01 02; 10(1):40-49. Kojayan GG, Alexander M, Imagawa DK, Lakey JRT. PMID: 29315020; PMCID: PMC5800373.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    45. Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet-transplantation enhances immediate post-transplant islet graft function but not long-term normoglycemia. J Biomed Mater Res A. 2017 Sep; 105(9):2533-2542. Smink AM, Li S, Swart DH, Hertsig DT, de Haan BJ, Kamps JAAM, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JRT, de Vos P. PMID: 28470672; PMCID: PMC5575460.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    46. The Efficacy of a Prevascularized, Retrievable Poly(D,L,-lactide-co-ε-caprolactone) Subcutaneous Scaffold as Transplantation Site for Pancreatic Islets. Transplantation. 2017 04; 101(4):e112-e119. Smink AM, Li S, Hertsig DT, de Haan BJ, Schwab L, van Apeldoorn AA, de Koning E, Faas MM, Lakey JR, de Vos P. PMID: 28207637; PMCID: PMC7228571.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    47. Immunological Challenges Facing Translation of Alginate Encapsulated Porcine Islet Xenotransplantation to Human Clinical Trials. Methods Mol Biol. 2017; 1479:305-333. Krishnan R, Ko D, Foster CE, Liu W, Smink AM, de Haan B, De Vos P, Lakey JR. PMID: 27738946.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    48. Developing a Rapid Algorithm to Enable Rapid Characterization of Alginate Microcapsules. Cell Transplant. 2017 05 09; 26(5):765-772. Chan KH, Krishnan R, Alexander M, Lakey JRT. PMID: 27729095; PMCID: PMC5657713.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    49. Physiologic Doses of Bilirubin Contribute to Tolerance of Islet Transplants by Suppressing the Innate Immune Response. Cell Transplant. 2017 01 24; 26(1):11-21. Adin CA, VanGundy ZC, Papenfuss TL, Xu F, Ghanem M, Lakey J, Hadley GA. PMID: 27393133; PMCID: PMC5657680.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    50. Total pancreatectomy and islet autotransplantation: A decade nationwide analysis. World J Transplant. 2016 Mar 24; 6(1):233-8. Fazlalizadeh R, Moghadamyeghaneh Z, Demirjian AN, Imagawa DK, Foster CE, Lakey JR, Stamos MJ, Ichii H. PMID: 27011922; PMCID: PMC4801800.
      View in: PubMed   Mentions: 7  
    51. Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence. PLoS One. 2016; 11(1):e0147992. de Vos P, Smink AM, Paredes G, Lakey JR, Kuipers J, Giepmans BN, de Haan BJ, Faas MM. PMID: 26824526; PMCID: PMC4732769.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Impact of donor age and weaning status on pancreatic exocrine and endocrine tissue maturation in pigs. Xenotransplantation. 2015 Sep-Oct; 22(5):356-67. Krishnan R, Truong N, Gerges M, Stiewig M, Neel N, Ho-Nguyen K, Kummerfeld C, Alexander M, Spizzo T, Martin M, Foster CE, Monuki ES, Lakey JR. PMID: 26381493.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    53. Human islet function following 20 years of cryogenic biobanking. Diabetologia. 2015 Jul; 58(7):1503-12. Manning Fox JE, Lyon J, Dai XQ, Wright RC, Hayward J, van de Bunt M, Kin T, Shapiro AM, McCarthy MI, Gloyn AL, Ungrin MD, Lakey JR, Kneteman NM, Warnock GL, Korbutt GS, Rajotte RV, MacDonald PE. PMID: 25930156; PMCID: PMC4472956.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    54. Young porcine endocrine pancreatic islets cultured in fibrin and alginate gels show improved resistance towards human monocytes. Pathol Biol (Paris). 2014 Dec; 62(6):354-64. Kuehn C, Fülöp T, Lakey JR, Vermette P. PMID: 25239278.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    55. Method measuring oxygen tension and transport within subcutaneous devices. J Biomed Opt. 2014 Aug; 19(8):087006. Weidling J, Sameni S, Lakey JR, Botvinick E. PMID: 25162910; PMCID: PMC4407670.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    56. Impact of hypothermic preservation on tissue yield and viability in pig pancreata. Transplant Proc. 2014 Jul-Aug; 46(6):1975-7. Alexander M, Krishnan R, Buder B, Lamb M, Laugenour K, Chapman D, Foster CE, Lakey JR. PMID: 25131086.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    57. Islet and stem cell encapsulation for clinical transplantation. Rev Diabet Stud. 2014; 11(1):84-101. Krishnan R, Alexander M, Robles L, Foster CE, Lakey JR. PMID: 25148368; PMCID: PMC4295801.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    58. Young porcine endocrine pancreatic islets cultured in fibrin show improved resistance toward hydrogen peroxide. Islets. 2013 Sep-Dec; 5(5):207-15. Kuehn C, Lakey JR, Lamb MW, Vermette P. PMID: 24262980; PMCID: PMC4010573.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    59. Noninvasive evaluation of the vascular response to transplantation of alginate encapsulated islets using the dorsal skin-fold model. Biomaterials. 2014 Jan; 35(3):891-8. Krishnan R, Arora RP, Alexander M, White SM, Lamb MW, Foster CE, Choi B, Lakey JR. PMID: 24176195; PMCID: PMC4057612.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    60. Current status of islet encapsulation. Cell Transplant. 2014; 23(11):1321-48. Robles L, Storrs R, Lamb M, Alexander M, Lakey JR. PMID: 23880554.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    61. In vitro maturation of viable islets from partially digested young pig pancreas. Cell Transplant. 2014 Mar; 23(3):263-72. Lamb M, Laugenour K, Liang O, Alexander M, Foster CE, Lakey JR. PMID: 23394130.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    62. Induction therapy by anti-thymocyte globulin (rabbit) versus basiliximab in deceased donor renal transplants and the effect on delayed graft function and outcomes. Transplant Proc. 2012 Jan; 44(1):164-6. Foster CE, Weng RR, Piper M, Laugenou K, Ichii H, Lakey J, Malinoski D. PMID: 22310605.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    63. GPR54 peptide agonists stimulate insulin secretion from murine, porcine and human islets. Islets. 2012 Jan-Feb; 4(1):20-3. Bowe JE, Foot VL, Amiel SA, Huang GC, Lamb MW, Lakey J, Jones PM, Persaud SJ. PMID: 22192948.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    64. Function and viability of human islets encapsulated in alginate sheets: in vitro and in vivo culture. Transplant Proc. 2011 Nov; 43(9):3265-6. Lamb M, Storrs R, Li S, Liang O, Laugenour K, Dorian R, Chapman D, Ichii H, Imagawa D, Foster C, King S, Lakey JR. PMID: 22099772.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    65. 18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies. J Nucl Med. 2011 Jul; 52(7):1125-32. Garcia A, Mirbolooki MR, Constantinescu C, Pan ML, Sevrioukov E, Milne N, Wang PH, Lakey J, Chandy KG, Mukherjee J. PMID: 21680697.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    66. Pancreatic duct: A suitable route to oxygenate tissue during pancreas hypothermic preservation? Transpl Immunol. 2010 Feb; 22(3-4):191-4. Mirbolooki MR, Alexander M, Hoyt DB, Lakey JR. PMID: 19900551.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    67. Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications? Med Hypotheses. 2009 Sep; 73(3):363-9. Mirbolooki MR, Taylor GE, Knutzen VK, Scharp DW, Willcourt R, Lakey JR. PMID: 19446964.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    68. The use of an approved biodegradable polymer scaffold as a solid support system for improvement of islet engraftment. Artif Organs. 2008 Dec; 32(12):990-3. Kin T, O'Neil JJ, Pawlick R, Korbutt GS, Shapiro AM, Lakey JR. PMID: 19133030.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    69. Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids. J Endocrinol. 2008 Mar; 196(3):455-64. Bikopoulos G, da Silva Pimenta A, Lee SC, Lakey JR, Der SD, Chan CB, Ceddia RB, Wheeler MB, Rozakis-Adcock M. PMID: 18310441.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    70. Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice. Cell Transplant. 2008; 17(6):631-40. Suarez-Pinzon WL, Lakey JR, Rabinovitch A. PMID: 18819251.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    71. Long-Term Graft Function after Allogeneic Islet Transplantation. Cell Transplant. 2007 Apr; 16(4):441-446. Lakey JRT, Kin T, Warnock GL, Shapiro AMJ, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA. PMID: 28858603.
      View in: PubMed   Mentions: 1     Fields:    
    72. Enhancing the success of human islet isolation through optimization and characterization of pancreas dissociation enzyme. Am J Transplant. 2007 May; 7(5):1233-41. Kin T, Zhai X, Murdoch TB, Salam A, Shapiro AM, Lakey JR. PMID: 17359501.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    73. Detection of Microbial Contamination during Human Islet Isolation. Cell Transplant. 2007 Jan; 16(1):9-13. Kin T, Rosichuk S, Shapiro AMJ, Lakey JRT. PMID: 28880675.
      View in: PubMed   Mentions: 3     Fields:    
    74. Detection of microbial contamination during human islet isolation. Cell Transplant. 2007; 16(1):9-13. Kin T, Rosichuk S, Shapiro AM, Lakey JR. PMID: 17436850.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    75. Long-term graft function after allogeneic islet transplantation. Cell Transplant. 2007; 16(4):441-6. Lakey JR, Kin T, Warnock GL, Shapiro AM, Tsapogas P, Imes S, Korbutt GS, Kneteman NM, Rajotte RV, Ryan EA. PMID: 17658134.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    76. Compaction of islets is detrimental to transplant outcome in mice. Transplantation. 2006 Dec 15; 82(11):1472-6. Merani S, Schur C, Truong W, Knutzen VK, Lakey JR, Anderson CC, Ricordi C, Shapiro AM. PMID: 17164719.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    77. Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier. Am J Transplant. 2006 Dec; 6(12):2861-70. Avila JG, Wang Y, Barbaro B, Gangemi A, Qi M, Kuechle J, Doubleday N, Doubleday M, Churchill T, Salehi P, Shapiro J, Philipson LH, Benedetti E, Lakey JR, Oberholzer J. PMID: 17062000.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    78. Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbon. Transplantation. 2006 Nov 27; 82(10):1286-90. Kin T, Mirbolooki M, Salehi P, Tsukada M, O'Gorman D, Imes S, Ryan EA, Shapiro AM, Lakey JR. PMID: 17130776.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    79. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006 Sep 28; 355(13):1318-30. Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR. PMID: 17005949.
      View in: PubMed   Mentions: 677     Fields:    Translation:HumansCTClinical Trials
    80. Culture medium modulates proinflammatory conditions of human pancreatic islets before transplantation. Am J Transplant. 2006 Nov; 6(11):2791-5. Marzorati S, Antonioli B, Nano R, Maffi P, Piemonti L, Giliola C, Secchi A, Lakey JR, Bertuzzi F. PMID: 16939517.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    81. The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells. Diabetologia. 2006 Oct; 49(10):2341-9. Bussiere CT, Lakey JR, Shapiro AM, Korbutt GS. PMID: 16896936.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    82. Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in in vitro cell cultures. Exp Cell Res. 2006 Oct 15; 312(17):3404-12. Fukazawa T, Matsuoka J, Naomoto Y, Nakai T, Durbin ML, Kojima I, Lakey JR, Tanaka N. PMID: 16934249.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    83. Stem cell sources for clinical islet transplantation in type 1 diabetes: embryonic and adult stem cells. Med Hypotheses. 2006; 67(4):909-13. Miszta-Lane H, Mirbolooki M, James Shapiro AM, Lakey JR. PMID: 16762516.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    84. Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjects. Diabetes Technol Ther. 2006 Apr; 8(2):165-73. Paty BW, Senior PA, Lakey JR, Shapiro AM, Ryan EA. PMID: 16734547.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    85. Maintenance of Mouse, Rat, and Pig Pancreatic Islet Functions by Coculture with Human Islet-Derived Fibroblasts. Cell Transplant. 2006 Apr; 15(4):325-334. Miki A, Narushima M, Okitsu T, Takeno Y, Soto-Gutierrez A, Rivas-Carrillo JD, Navarro-Alvarez N, Chen Y, Tanaka K, Noguchi H, Matsumoto S, Kohara M, Lakey JRT, Kobayashi E, Tanaka N, Kobayashi N. PMID: 28863744.
      View in: PubMed   Mentions: 1     Fields:    
    86. Maintenance of mouse, rat, and pig pancreatic islet functions by coculture with human islet-derived fibroblasts. Cell Transplant. 2006; 15(4):325-34. Miki A, Narushima M, Okitsu T, Takeno Y, Soto-Gutierrez A, Rivas-Carrillo JD, Navarro-Alvarez N, Chen Y, Tanaka K, Noguchi H, Matsumoto S, Kohara M, Lakey JR, Kobayashi E, Tanaka N, Kobayashi N. PMID: 16898226.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    87. Estimation of pancreas weight from donor variables. Cell Transplant. 2006; 15(2):181-5. Kin T, Murdoch TB, Shapiro AM, Lakey JR. PMID: 16719052.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    88. Current status of clinical islet cell transplantation. Methods Mol Biol. 2006; 333:47-104. Lakey JR, Mirbolooki M, Shapiro AM. PMID: 16790847.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    89. Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solution. Cell Transplant. 2006; 15(2):187-94. Salehi P, Mirbolooki M, Kin T, Tsujimura T, Shapiro AM, Churchill TA, Lakey JR. PMID: 16719053.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    90. Comparison of cooling systems during islet purification. Cell Transplant. 2006; 15(2):175-80. Swift S, Kin T, Mirbolooki M, Wilson R, Lakey JR. PMID: 16719051.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    91. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Am J Transplant. 2005 Oct; 5(10):2368-77. Gustavson SM, Rajotte RV, Hunkeler D, Lakey JR, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cherrington AD. PMID: 16162184.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    92. A human beta-cell line for transplantation therapy to control type 1 diabetes. Nat Biotechnol. 2005 Oct; 23(10):1274-82. Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW. PMID: 16186810.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    93. Five-year follow-up after clinical islet transplantation. Diabetes. 2005 Jul; 54(7):2060-9. Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JR, Shapiro AM. PMID: 15983207.
      View in: PubMed   Mentions: 533     Fields:    Translation:Humans
    94. Strategic opportunities in clinical islet transplantation. Transplantation. 2005 May 27; 79(10):1304-7. Shapiro AM, Lakey JR, Paty BW, Senior PA, Bigam DL, Ryan EA. PMID: 15912095.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    95. Islet isolation and transplantation from an annular pancreas: a case report. JOP. 2005 May 10; 6(3):274-6. Kin T, Shapiro J, Ryan EA, Lakey JR. PMID: 15883480.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    96. The standardization of pancreatic donors for islet isolation. Transplant Proc. 2005 Mar; 37(2):1309-10. O'Gorman D, Kin T, Murdoch T, Richer B, McGhee-Wilson D, Ryan E, Shapiro AM, Lakey JR. PMID: 15848705.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    97. Beta-score: an assessment of beta-cell function after islet transplantation. Diabetes Care. 2005 Feb; 28(2):343-7. Ryan EA, Paty BW, Senior PA, Lakey JR, Bigam D, Shapiro AM. PMID: 15677790.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    98. Clinical islet transplantation at the University of Alberta--the Edmonton experience. Clin Transpl. 2005; 153-72. Truong W, Lakey JR, Ryan EA, Shapiro AM. PMID: 17424733.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    99. Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome. Diabetes. 2004 Dec; 53(12):3107-14. Street CN, Lakey JR, Shapiro AM, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T, Korbutt GS. PMID: 15561940.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    100. Cross-sectional and prospective association between proinsulin secretion and graft function after clinical islet transplantation. Transplantation. 2004 Sep 27; 78(6):934-7. McDonald CG, Ryan EA, Paty BW, Senior PA, Marshall SM, Lakey JR, Shapiro AM. PMID: 15385817.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    101. Methods of Human Islet Culture for Transplantation. Cell Transplant. 2004 Sep; 13(6):605-618. Murdoch TB, McGhee-Wilson D, Shapiro AMJ, Lakey JRT. PMID: 28880655.
      View in: PubMed   Mentions: 5     Fields:    
    102. Maintenance of glucose-sensitive insulin secretion of cryopreserved human islets with University of Wisconsin solution and ascorbic acid-2 glucoside. Artif Organs. 2004 Jun; 28(6):529-36. Arata T, Okitsu T, Fukazawa T, Ikeda H, Kobayashi K, Yong C, Kosaka Y, Narushima M, Matsuoka J, Yamamoto I, Tanaka N, Lakey JR, Kobayashi N. PMID: 15153144.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    103. Enhanced recovery of cryopreserved islets using SIS. Transplant Proc. 2004 May; 36(4):1139-42. Woods EJ, Walsh CM, Sidner RA, Zieger MA, Mullin S, Lakey JR, Ricordi C, Critser JK. PMID: 15194397.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    104. Improved in vitro function of islets using small intestinal submucosa. Transplant Proc. 2004 May; 36(4):1175-7. Woods EJ, Walsh CM, Sidner RA, Zieger MA, Lakey JR, Ricordi C, Critser JK. PMID: 15194407.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    105. Prevalence of hepatic steatosis after islet transplantation and its relation to graft function. Diabetes. 2004 May; 53(5):1311-7. Bhargava R, Senior PA, Ackerman TE, Ryan EA, Paty BW, Lakey JR, Shapiro AM. PMID: 15111501.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    106. Endogenous Pancreatic Enzyme Activity Levels Show no Significant Effect on Human Islet Isolation Yield. Cell Transplant. 2004 Mar; 13(2):153-160. Rose NL, Palcic MM, Shapiro AMJ, Lakey JRT. PMID: 28853934.
      View in: PubMed   Mentions:    Fields:    
    107. Assessment of Different Transfection Parameters in Efficiency Optimization. Cell Transplant. 2004 Mar; 13(2):179-185. Young ATL, Moore RB, Murray AG, Mullen JC, Lakey JRT. PMID: 28853931.
      View in: PubMed   Mentions: 1     Fields:    
    108. Assessment of different transfection parameters in efficiency optimization. Cell Transplant. 2004; 13(2):179-85. Young AT, Moore RB, Murray AG, Mullen JC, Lakey JR. PMID: 15129764.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    109. Endogenous pancreatic enzyme activity levels show no significant effect on human islet isolation yield. Cell Transplant. 2004; 13(2):153-60. Rose NL, Palcic MM, Shapiro AM, Lakey JR. PMID: 15129761.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    110. Methods of human islet culture for transplantation. Cell Transplant. 2004; 13(6):605-17. Murdoch TB, McGhee-Wilson D, Shapiro AM, Lakey JR. PMID: 15648731.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    111. Variation in human islet viability based on different membrane integrity stains. Cell Transplant. 2004; 13(5):481-8. Barnett MJ, McGhee-Wilson D, Shapiro AM, Lakey JR. PMID: 15565860.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    112. Short-term storage of the ischemically damaged human pancreas by the two-layer method prior to islet isolation. Cell Transplant. 2004; 13(1):67-73. Tsujimura T, Kuroda Y, Churchill TA, Avila JG, Kin T, Shapiro AM, Lakey JR. PMID: 15040607.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    113. An evaluation of endogenous pancreatic enzyme levels following enzymatic digestion. Transplant Proc. 2003 Nov; 35(7):2458-60. Rose NL, Palcic MM, Shapiro AM, Lakey JR. PMID: 14611985.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    114. Improvement of Pancreatic Islet Isolation Outcomes Using Glutamine Perfusion during Isolation Procedure. Cell Transplant. 2003 Nov; 12(8):877-881. Avila JG, Tsujimura T, Oberholzer J, Churchill T, Salehi P, Shapiro AMJ, Lakey JRT. PMID: 28863737.
      View in: PubMed   Mentions: 3     Fields:    
    115. Improvement of pancreatic islet isolation outcomes using glutamine perfusion during isolation procedure. Cell Transplant. 2003; 12(8):877-81. Avila JG, Tsujimura T, Oberholzer J, Churchill T, Salehi P, Shapiro AM, Lakey JR. PMID: 14763507.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    116. Dynamics of cryoprotectant permeation in porcine heart valve leaflets. Cell Transplant. 2003; 12(2):123-8. Lakey JR, Helms LM, Moser G, Lix B, Slupsky CM, Rebeyka IM, Sykes BD, McGann LE. PMID: 12797373.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    117. Human islet transplantation from pancreases with prolonged cold ischemia using additional preservation by the two-layer (UW solution/perfluorochemical) cold-storage method. Transplantation. 2002 Dec 27; 74(12):1687-91. Tsujimura T, Kuroda Y, Kin T, Avila JG, Rajotte RV, Korbutt GS, Ryan EA, Shapiro AM, Lakey JR. PMID: 12499881.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    118. Evaluating the Effect of Serine Proteases on Collagenase Activity during Human Islet Isolation. Cell Transplant. 2002 Nov; 11(8):821-826. Rose NL, Palcic MM, Lakey JRT. PMID: 28871858.
      View in: PubMed   Mentions:    Fields:    
    119. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes. 2002 Jul; 51(7):2148-57. Ryan EA, Lakey JR, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV, Shapiro AM. PMID: 12086945.
      View in: PubMed   Mentions: 146     Fields:    Translation:Humans
    120. Evaluating the effect of serine proteases on collagenase activity during human islet isolation. Cell Transplant. 2002; 11(8):821-6. Rose NL, Palcic MM, Lakey JR. PMID: 12588115.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    121. Diabetes. Islet cell transplantation. Lancet. 2001 Dec; 358 Suppl:S21. Shapiro AM, Ryan EA, Lakey JR. PMID: 11784570.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    122. Clinical results after islet transplantation. J Investig Med. 2001 Nov; 49(6):559-62. Ryan EA, Lakey JR, Shapiro AM. PMID: 11730091.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    123. Clinical islet transplant--state of the art. Transplant Proc. 2001 Nov-Dec; 33(7-8):3502-3. Shapiro AM, Ryan EA, Lakey JR. PMID: 11750497.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    124. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes. 2001 Apr; 50(4):710-9. Ryan EA, Lakey JR, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kneteman NM, Warnock GL, Larsen I, Shapiro AM. PMID: 11289033.
      View in: PubMed   Mentions: 182     Fields:    Translation:Humans
    125. Osmotic and cryoprotectant permeation characteristics of islet cells isolated from the newborn pig pancreas. Cell Transplant. 2001; 10(7):651-9. Fedorow C, McGann LE, Korbutt GS, Rayat GR, Rajotte RV, Lakey JR. PMID: 11714201.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    126. Nonviral transfection of intact pancreatic islets. Cell Transplant. 2001; 10(8):697-708. Lakey JR, Young AT, Pardue D, Calvin S, Albertson TE, Jacobson L, Cavanagh TJ. PMID: 11814112.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    127. Islet cryopreservation using intracellular preservation solutions. Cell Transplant. 2001; 10(7):583-9. Lakey JR, Rajotte RV, Fedorow CA, Taylor MJ. PMID: 11714192.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    128. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000 Jul 27; 343(4):230-8. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV. PMID: 10911004.
      View in: PubMed   Mentions: 1306     Fields:    Translation:HumansCTClinical Trials
    129. Future trends in islet cell transplantation. Diabetes Technol Ther. 2000; 2(3):449-52. Shapiro AM, Lakey JR. PMID: 11467347.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    130. Comparison of amperometric methods for detection of exocytosis from single pancreatic beta-cells of different species. Anal Chem. 1999 Dec 15; 71(24):5551-6. Aspinwall CA, Huang L, Lakey JR, Kennedy RT. PMID: 10624159.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    131. The effects of microencapsulation on pancreatic islet osmotically induced volumetric response. Cell Transplant. 1999 Nov-Dec; 8(6):699-708. Woods EJ, Liu J, Zieger MA, Lakey JR, Critser JK. PMID: 10701498.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    132. Secretion from islets and single islet cells following cryopreservation. Cell Transplant. 1999 Nov-Dec; 8(6):691-8. Lakey JR, Aspinwall CA, Cavanagh TJ, Kennedy RT. PMID: 10701497.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    133. Water and cryoprotectant permeability characteristics of isolated human and canine pancreatic islets. Cell Transplant. 1999 Sep-Oct; 8(5):549-59. Woods EJ, Liu J, Zieger MA, Lakey JR, Critser JK. PMID: 10580349.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    134. Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival. FEBS Lett. 1999 Jul 23; 455(3):203-8. Paraskevas S, Aikin R, Maysinger D, Lakey JR, Cavanagh TJ, Hering B, Wang R, Rosenberg L. PMID: 10437773.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    135. Osmotic tolerance limits of canine pancreatic islets. Cell Transplant. 1999 May-Jun; 8(3):277-84. Zieger MA, Woods EJ, Lakey JR, Liu J, Critser JK. PMID: 10442740.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    136. Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion. Cell Transplant. 1999 May-Jun; 8(3):285-92. Lakey JR, Warnock GL, Shapiro AM, Korbutt GS, Ao Z, Kneteman NM, Rajotte RV. PMID: 10442741.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    137. Insulin-stimulated insulin secretion in single pancreatic beta cells. J Biol Chem. 1999 Mar 05; 274(10):6360-5. Aspinwall CA, Lakey JR, Kennedy RT. PMID: 10037726.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    138. A prospective comparison of discontinuous EuroFicoll and EuroDextran gradients for islet purification. Cell Transplant. 1998 Sep-Oct; 7(5):479-87. Lakey JR, Cavanagh TJ, Zieger MA. PMID: 9786068.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    139. Evaluation of a purified enzyme blend for the recovery and function of canine pancreatic islets. Cell Transplant. 1998 Jul-Aug; 7(4):365-72. Lakey JR, Cavanagh TJ, Zieger MA, Wright M. PMID: 9710305.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    140. Effect of cryopreservation on the survival and function of murine islet isografts and allografts. Cell Transplant. 1998 Jul-Aug; 7(4):373-9. Cattral MS, Lakey JR, Warnock GL, Kneteman NM, Rajotte RV. PMID: 9710306.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    141. Effect of cryopreservation on canine islet insulin secretion as measured by amperometric techniques. Transplant Proc. 1998 Mar; 30(2):382. Lakey JR, Aspinwall CA, Cavanagh TJ, Kennedy RT. PMID: 9532091.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    142. Improved pig islet yield and post-culture recovery using Liberase PI purified enzyme blend. Transplant Proc. 1998 Mar; 30(2):367. Cavanagh TJ, Lakey JR, Dwulet F, Wright MJ, Wile K, Albertson T, Fetterhoff T. PMID: 9532083.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    143. Identification of a pig strain with maximal islet mass. Transplant Proc. 1998 Mar; 30(2):368. Cavanagh TJ, Lakey JR, Wright MJ, Albertson T, Wile K, Fetterhoff TJ. PMID: 9532084.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    144. Improved islet survival and in vitro function using small intestinal submucosa. Transplant Proc. 1998 Mar; 30(2):383. Lakey JR, Troendle J, Zieger MA, Geary WA, Voytek S, Critser JK. PMID: 9532092.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    145. Effects of intravesicular H+ and extracellular H+ and Zn2+ on insulin secretion in pancreatic beta cells. J Biol Chem. 1997 Dec 12; 272(50):31308-14. Aspinwall CA, Brooks SA, Kennedy RT, Lakey JR. PMID: 9395458.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    146. Hypoosmotic exposure of canine pancreatic digest as a means to purify islet tissue. Cell Transplant. 1997 Jul-Aug; 6(4):423-8. Lakey JR, Zieger MA, Woods EJ, Liu J, Critser JK. PMID: 9258516.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    147. Development of an automated computer-controlled islet isolation system. Transplant Proc. 1997 Jun; 29(4):1956. Lakey JR, Warnock GL, Brierton M, Ao Z, Hering BJ, London N, Ricordi C, Corbin F, Rajotte RV. PMID: 9193472.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    148. Crude collagenase loses islet-isolating efficacy regardless of storage conditions. Transplant Proc. 1997 Jun; 29(4):1942-4. Cavanagh TJ, Lakey JR, Wright MJ, Fetterhoff T, Wile K. PMID: 9193463.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    149. Comparison of methods used for the removal of DMSO following cryopreservation and the development of an automated protocol. Cell Transplant. 1997 Mar-Apr; 6(2):163-72. Lakey JR, Warnock GL, Rajotte RV. PMID: 9142448.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    150. Development of an automated computer-controlled islet isolation system. Cell Transplant. 1997 Jan-Feb; 6(1):47-57. Lakey JR, Warnock GL, Brierton M, Ao Z, Hering BJ, London NJ, Ricordi C, Corbin F, Rajotte RV. PMID: 9040955.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    151. Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab. 1996 Sep; 81(9):3197-202. Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JR, Rajotte RV. PMID: 8784069.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    152. Bulk cryopreservation of isolated islets of Langerhans. Cell Transplant. 1996 May-Jun; 5(3):395-404. Lakey JR, Warnock GL, Ao Z, Rajotte RV. PMID: 8727008.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    153. The metabolic impact of rapamycin (sirolimus) in chronic canine islet graft recipients. Transplantation. 1996 Apr 27; 61(8):1206-10. Kneteman NM, Lakey JR, Wagner T, Finegood D. PMID: 8610419.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    154. Natural history of insulin independence after transplantation of multidonor cryopreserved pancreatic islets in type 1 diabetic humans. Transplant Proc. 1995 Dec; 27(6):3159-60. Warnock GI, Tsapogas P, Ryan EA, Lakey JR, Korbutt G, Kneteman NM, Ao Z, Rabinovitch A, Rajotte RV. PMID: 8539888.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    155. Effect of cryopreservation on islet recovery and in vivo function. Transplant Proc. 1995 Dec; 27(6):3336. Cattral MS, Lakey JR, Warnock GL, Kneteman NM, Rajotte RV. PMID: 8539978.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    156. Dose dependence of bacillus Calmette-Guerin on the prevention of autoimmune diabetes in syngeneic islet transplantation. Transplant Proc. 1995 Dec; 27(6):3413. Lakey JR, Singh B, Warnock GL, Elliott JF, Rajotte RV. PMID: 8540025.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    157. Recovery and in vivo function of canine islets cryopreserved in a freezer bag. Transplant Proc. 1995 Dec; 27(6):3266. Lakey JR, Ao Z, Warnock GL, Korbutt GS, Flashner M, Colby CB, Rajotte RV. PMID: 8539946.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    158. Human pancreas preservation prior to islet isolation. Cold ischemic tolerance. Transplantation. 1995 Mar 15; 59(5):689-94. Lakey JR, Rajotte RV, Warnock GL, Kneteman NM. PMID: 7886793.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    159. Survival and function of human islets subjected to gamma-radiation. Transplant Proc. 1994 Dec; 26(6):3457. Gainer AL, Lakey JR, Rajotte RV, Warnock GL. PMID: 7998220.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    160. Adjuvant immunotherapy with Bacillus Calmette-Guerin prevents recurrence of diabetes in islet grafts transplanted into NOD mice. Transplant Proc. 1994 Apr; 26(2):736. Lakey JR, Warnock GL, Singh B, Rajotte RV. PMID: 8171632.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    161. Effects of pre-cryopreservation culture on human islet recovery and in vitro function. Transplant Proc. 1994 Apr; 26(2):820. Lakey JR, Warnock GL, Kneteman NM, Ao Z, Rajotte RV. PMID: 8171675.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    162. Rat heart fatty acid-binding protein content is increased in experimental diabetes. Biochem Biophys Res Commun. 1994 Mar 15; 199(2):639-46. Glatz JF, van Breda E, Keizer HA, de Jong YF, Lakey JR, Rajotte RV, Thompson A, van der Vusse GJ, Lopaschuk GD. PMID: 8135805.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    163. Bacteremia due to transplantation of contaminated cryopreserved pancreatic islets. Cell Transplant. 1994 Jan-Feb; 3(1):103-6. Taylor GD, Kirkland T, Lakey J, Rajotte R, Warnock GL. PMID: 8162286.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    164. Prolongation of canine pancreatic islet allograft survival with combined rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related. Transplantation. 1993 Dec; 56(6):1293-8. Yakimets WJ, Lakey JR, Yatscoff RW, Katyal D, Ao Z, Finegood DT, Rajotte RV, Kneteman NM. PMID: 8278991.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    165. The efficacy and toxicity of rapamycin in murine islet transplantation. In vitro and in vivo studies. Transplantation. 1993 Nov; 56(5):1137-42. Fabian MC, Lakey JR, Rajotte RV, Kneteman NM. PMID: 8249114.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    166. Human islet purification with discontinuous density gradients following cold storage of the pancreas. Transplant Proc. 1993 Feb; 25(1 Pt 2):957-8. Lakey JR, Warnock GL, Seelis RE, Ao Z, Kneteman NM, Rajotte RV. PMID: 8442278.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    167. Rapamycin prolongs murine islet allograft survival. Transplant Proc. 1992 Dec; 24(6):2842. Fabian MC, Lakey JR, Rajotte RV, Kneteman NM. PMID: 1465966.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    168. Collagenase digestion of canine pancreas by gentle automated dissociation in combination with ductal perfusion optimizes mass recovery of islets. Transplant Proc. 1992 Dec; 24(6):2787. Ao Z, Lakey JR, Rajotte RV, Warnock GL. PMID: 1465938.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    169. Prevention of recurrence of insulin-dependent diabetes mellitus in islet cell-transplanted diabetic NOD mice using adjuvant therapy. Transplant Proc. 1992 Dec; 24(6):2848. Lakey JR, Wang T, Warnock GL, Singh B, Rajotte RV. PMID: 1465969.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    170. A comparison of human islet purification with discontinuous density gradients of Ficoll prepared with Euro-Collins or medium 199 solution. Transplant Proc. 1992 Dec; 24(6):2825. Lakey JR, Warnock GL, Seelis RE, Ao Z, Kneteman NM, Rajotte RV. PMID: 1465957.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    171. The natural history of transplantation of insulin-producing pancreatic islets into type I diabetic patients. Transplant Proc. 1992 Dec; 24(6):3058. Warnock GL, Ryan EA, Kneteman NM, Ao Z, Lakey JR, Rajotte RV. PMID: 1466056.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    172. Comparison of dextran and Ficoll density gradients for purification of canine islets. Transplant Proc. 1992 Dec; 24(6):2788. Ao Z, Matayoshi K, Yakimets WJ, Lakey JR, Katyal D, Rajotte RV, Warnock GL. PMID: 1281574.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    173. Optimal temperature in short-term hypothermic preservation of rat pancreas. Transplantation. 1991 May; 51(5):977-81. Lakey JR, Wang LC, Rajotte RV. PMID: 2031282.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
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