Matthew F Rose

Title(s)Assistant Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(713) 294-7416
ORCID ORCID Icon0000-0002-1148-4130 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Brigham & Women's Hospital, Boston Children's Hospital, The Broad Institute, Harvard Medical School, Boston, MAClinical Scientist Postdoctoral Training09/2021Neurodevelopment, Imaging, & Bioinformatics
    Brigham & Women's Hospital, Boston Children's Hospital, Harvard Medical School, Boston, MAFellowship06/2014Neuropathology
    Brigham & Women's Hospital, Harvard Medical School, Boston, MAResidency06/2012Anatomic Pathology
    Baylor College of Medicine, Houston, TXMD12/2009Medicine
    Baylor College of Medicine, Houston, TXPhD08/2008Developmental Neurogenetics
    University of Virginia, Charlottesville, VABS05/2000Chemistry and Neuroscience

    Collapse Overview 
    Collapse Overview
    We study the gene networks driving neuronal diversity during brainstem development to uncover why only specific subsets are differentially affected in a given human neurologic disease. The brainstem controls multiple critical motor and sensory functions, including eye movements, facial expression, speech, hearing, proprioception, arousal, and breathing. Disruption of these functions can lead to profound deficits including in childhood social interaction. The anatomy and gene circuits in the brainstem are highly conserved in mice, providing an ideal model system to investigate neuronal specification and axon growth and guidance in both health and disease. We combine neurodevelopmental tools, 3D imaging, multi-omics/bioinformatic approaches, molecular/synthetic biology, and mouse models of human disease to define developmental differences among various neuronal populations. Through a single cell and spatial transcriptomic atlas of developing motor neurons, we have identified unique genetic fingerprints of each motor neuron population, including novel markers of spatially and temporally distinct subpopulations that contribute to specific aberrant nerve branches in mouse models of childhood disorders. This work provides a new toolbox to study differential neuronal vulnerability in disease. MENTORING: I consider mentoring and training the next generation of scientists one of my primary goals. I’ve pursued research since an early age, supported by many wonderful mentors and teachers along the way. I have progressively developed approaches in critical thinking, imaging, cell culture, animal work, bioinformatics, and neuropathology through work in the laboratories of Jeff Corwin, PhD (University of Virginia), Huda Zoghbi, MD and Hugo Bellen, PhD (Baylor College of Medicine), Jeff Lichtman, MD/PhD (The Marine Biological Laboratory), Elizabeth Engle, MD (Harvard Medical School), & Aviv Regev, PhD (The Broad Institute of MIT & Harvard), among many others. I’m also a clinical neuropathologist and look for areas to apply our research findings to medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    Mapping Brainstem Motor Neuron Subtypes and Genetic Pathways Involved in their Differential Susceptibility to Disease
    NIH K08NS099502Dec 1, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Role of Math1 in brain stem &cerebellar development
    NIH F31NS051046Sep 30, 2004 - Oct 31, 2007
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders. medRxiv. 2023 Dec 27. Lee AS, Ayers LJ, Kosicki M, Chan WM, Fozo LN, Pratt BM, Collins TE, Zhao B, Rose MF, Sanchis-Juan A, Fu JM, Wong I, Zhao X, Tenney AP, Lee C, Laricchia KM, Barry BJ, Bradford VR, Lek M, MacArthur DG, Lee EA, Talkowski ME, Brand H, Pennacchio LA, Engle EC. PMID: 38234731; PMCID: PMC10793524.
      View in: PubMed   Mentions:
    2. Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. Elife. 2019 06 03; 8. An D, Fujiki R, Iannitelli DE, Smerdon JW, Maity S, Rose MF, Gelber A, Wanaselja EK, Yagudayeva I, Lee JY, Vogel C, Wichterle H, Engle EC, Mazzoni EO. PMID: 31157617; PMCID: PMC6594754.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    3. A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. Nat Commun. 2017 07 06; 8:16077. Di Gioia SA, Connors S, Matsunami N, Cannavino J, Rose MF, Gilette NM, Artoni P, de Macena Sobreira NL, Chan WM, Webb BD, Robson CD, Cheng L, Van Ryzin C, Ramirez-Martinez A, Mohassel P, Leppert M, Scholand MB, Grunseich C, Ferreira CR, Hartman T, Hayes IM, Morgan T, Markie DM, Fagiolini M, Swift A, Chines PS, Speck-Martins CE, Collins FS, Jabs EW, Bönnemann CG, Olson EN, Moebius Syndrome Research Consortium, Carey JC, Robertson SP, Manoli I, Engle EC. PMID: 28681861; PMCID: PMC5504296.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    4. ARID1A and TERT promoter mutations in dedifferentiated meningioma. Cancer Genet. 2015 Jun; 208(6):345-50. Abedalthagafi MS, Bi WL, Merrill PH, Gibson WJ, Rose MF, Du Z, Francis JM, Du R, Dunn IF, Ligon AH, Beroukhim R, Santagata S. PMID: 25963524; PMCID: PMC4882906.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    5. Immunohistochemical investigations of adult intraocular medulloepitheliomas. Clin Exp Ophthalmol. 2015 May-Jun; 43(4):379-85. Jakobiec FA, Rose MF, Trief D, Stagner AM, Kim I, Gragoudas ES. PMID: 25251824.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Clinical Reasoning: a 75-year-old man with 3 years of visual difficulties. Neurology. 2014 Oct 21; 83(17):e160-5. Berkowitz AL, Rose MF, Daffner KR, Prasad S. PMID: 25332451; PMCID: PMC4222854.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. New insights into the development of infantile intraocular medulloepithelioma. Am J Ophthalmol. 2014 Dec; 158(6):1275-1296.e1. Jakobiec FA, Trief D, Rashid A, Rose MF, Minckler D, Vanderveen D, Mukai S. PMID: 25174896.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Atypical presentation of cerebral schistosomiasis four years after exposure to Schistosoma mansoni. Epilepsy Behav Case Rep. 2014; 2:80-5. Rose MF, Zimmerman EE, Hsu L, Golby AJ, Saleh E, Folkerth RD, Santagata SS, Milner DA, Ramkissoon SH. PMID: 25667876; PMCID: PMC4308089.
      View in: PubMed   Mentions: 7  
    9. Bilirubin labeling of borderzone and anterior cerebral artery territory infarction. Neurology. 2013 Oct 01; 81(14):1272-3. Berkowitz AL, Sheu SH, Rose MF, Delalle I, Folkerth RD. PMID: 24081962; PMCID: PMC3795605.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. Dev Biol. 2013 Apr 01; 376(1):86-98. Driver EC, Sillers L, Coate TM, Rose MF, Kelley MW. PMID: 23318633; PMCID: PMC3652277.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    11. Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22462-7. Rose MF, Ahmad KA, Thaller C, Zoghbi HY. PMID: 20080794; PMCID: PMC2799716.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    12. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12; 64(3):341-54. Rose MF, Ren J, Ahmad KA, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY. PMID: 19914183; PMCID: PMC2818435.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    13. Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter. J Neurosci. 2006 Sep 06; 26(36):9184-95. Englund C, Kowalczyk T, Daza RA, Dagan A, Lau C, Rose MF, Hevner RF. PMID: 16957075; PMCID: PMC6674506.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    14. The roof plate regulates cerebellar cell-type specification and proliferation. Development. 2006 Aug; 133(15):2793-804. Chizhikov VV, Lindgren AG, Currle DS, Rose MF, Monuki ES, Millen KJ. PMID: 16790481.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    15. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17551-8. Young JI, Hong EP, Castle JC, Crespo-Barreto J, Bowman AB, Rose MF, Kang D, Richman R, Johnson JM, Berget S, Zoghbi HY. PMID: 16251272; PMCID: PMC1266160.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    16. Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron. 2005 Oct 06; 48(1):31-43. Wang VY, Rose MF, Zoghbi HY. PMID: 16202707.
      View in: PubMed   Mentions: 252     Fields:    Translation:AnimalsCells
    17. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. PMID: 16122429.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    18. Senseless is required for pupal retinal development in Drosophila. Genesis. 2004 Apr; 38(4):182-94. Frankfort BJ, Pepple KL, Mamlouk M, Rose MF, Mardon G. PMID: 15083519.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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