Mathew Mark Blurton-Jones

Title(s)Associate Professor, Neurobiology & Behavior
SchoolSchool of Biological Sciences
AddressZot 1695
Irvine CA 92697
Phone(949) 824-5243
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    A novel platform for the investigation of human microglia
    NIH RF1DA048813Aug 15, 2019 - Aug 14, 2022
    Role: Co-Principal Investigator
    Examining the role of adaptive immunity in Alzheimer's Disease pathogenesis
    NIH RF1AG055524Sep 15, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Manipulating DNA repair enzymes to examine the interactions between aging and Alzheimers disease with iPSC-derived microglia
    NIH R01AG056303Jul 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    The role of TREM2 in human microglial function and Alzheimer disease pathogenesis
    NIH RF1AG048099Sep 15, 2014 - Jun 30, 2019
    Role: Principal Investigator
    The Role of Beta-Amyloid Assembly States in Tau Pathology and Cognitive Decline
    NIH K01AG029378Apr 15, 2008 - Mar 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2024 Mar 25; 15(1):88. Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. PMID: 38523285; PMCID: PMC10962161.
      View in: PubMed   Mentions:    Fields:    
    2. Genetic contribution to microglial activation in schizophrenia. Mol Psychiatry. 2024 Mar 22. Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu YC, Trontti K, McQuade A, Kalyanaraman S, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T, Lehtonen Š, Tiihonen J, Koistinaho J. PMID: 38519640.
      View in: PubMed   Mentions:    Fields:    
    3. Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. Adv Sci (Weinh). 2024 Mar 14; e2304357. Kang YJ, Hyeon SJ, McQuade A, Lim J, Baek SH, Diep YN, Do KV, Jeon Y, Jo DG, Lee CJ, Blurton-Jones M, Ryu H, Cho H. PMID: 38482922.
      View in: PubMed   Mentions:    Fields:    
    4. ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia. bioRxiv. 2024 Jan 19. Granzotto A, McQuade A, Chadarevian JP, Davtyan H, Sensi SL, Parker I, Blurton-Jones M, Smith I. PMID: 38293075; PMCID: PMC10827168.
      View in: PubMed   Mentions:
    5. Microglial APOE4: more is less and less is more. Mol Neurodegener. 2023 Dec 19; 18(1):99. Eskandari-Sedighi G, Blurton-Jones M. PMID: 38115077; PMCID: PMC10729371.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis. Nat Cell Biol. 2023 Dec; 25(12):1848-1859. Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodríguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA. PMID: 37957324.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Human microglia maturation is underpinned by specific gene regulatory networks. Immunity. 2023 09 12; 56(9):2152-2171.e13. Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA, Birth Defects Research Laboratory, Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. PMID: 37582369; PMCID: PMC10529991.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model. Cell Death Dis. 2023 08 03; 14(8):496. Liaudanskaya V, Fiore NJ, Zhang Y, Milton Y, Kelly MF, Coe M, Barreiro A, Rose VK, Shapiro MR, Mullis AS, Shevzov-Zebrun A, Blurton-Jones M, Whalen MJ, Symes AJ, Georgakoudi I, Nieland TJF, Kaplan DL. PMID: 37537168; PMCID: PMC10400598.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3. Brain Behav Immun. 2023 10; 113:353-373. Haukedal H, Syshøj Lorenzen S, Winther Westi E, Corsi GI, Gadekar VP, McQuade A, Davtyan H, Doncheva NT, Schmid B, Chandrasekaran A, Seemann SE, Cirera S, Blurton-Jones M, Meyer M, Gorodkin J, Aldana BI, Freude K. PMID: 37543250.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model. STAR Protoc. 2023 Sep 15; 4(3):102490. Chadarevian JP, Davtyan H, Lombroso SI, Bennett FC, Blurton-Jones M. PMID: 37516973; PMCID: PMC10407259.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nat Immunol. 2023 08; 24(8):1382-1390. Dolan MJ, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B. PMID: 37500887; PMCID: PMC10382323.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model. Cell Rep. 2023 08 29; 42(8):112841. Liu Z, Chao J, Wang C, Sun G, Roeth D, Liu W, Chen X, Li L, Tian E, Feng L, Davtyan H, Blurton-Jones M, Kalkum M, Shi Y. PMID: 37494190; PMCID: PMC10510531.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Author Correction: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies. NPJ Vaccines. 2023 Jul 17; 8(1):105. Kim C, Hovakimyan A, Zagorski K, Antonyan T, Petrushina I, Davtyan H, Chailyan G, Hasselmann J, Iba M, Adame A, Rockenstein E, Szabo M, Blurton-Jones M, Cribbs DH, Ghochikyan A, Masliah E, Agadjanyan MG. PMID: 37460684; PMCID: PMC10352336.
      View in: PubMed   Mentions:
    14. Novel Vaccine against Pathological Pyroglutamate-Modified Amyloid Beta for Prevention of Alzheimer's Disease. Int J Mol Sci. 2023 Jun 06; 24(12). Zagorski K, King O, Hovakimyan A, Petrushina I, Antonyan T, Chailyan G, Ghazaryan M, Hyrc KL, Chadarevian JP, Davtyan H, Blurton-Jones M, Cribbs DH, Agadjanyan MG, Ghochikyan A. PMID: 37372944; PMCID: PMC10298272.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features. Front Cell Neurosci. 2023; 17:1179796. Lorenzini I, Alsop E, Levy J, Gittings LM, Lall D, Rabichow BE, Moore S, Pevey R, Bustos LM, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota TA, Logemann A, Rose J, Almeida S, Gao FB, Marks M, Donnelly CJ, Hutchins E, Hung ST, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron TF, Baloh RH, Van Keuren-Jensen K, Sattler R. PMID: 37346371; PMCID: PMC10279871.
      View in: PubMed   Mentions: 6  
    16. Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2023 Mar 02; 14(1):1194. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 36864071; PMCID: PMC9981556.
      View in: PubMed   Mentions:    Fields:    
    17. Engineering an inhibitor-resistant human CSF1R variant for microglia replacement. J Exp Med. 2023 03 06; 220(3). Chadarevian JP, Lombroso SI, Peet GC, Hasselmann J, Tu C, Marzan DE, Capocchi J, Purnell FS, Nemec KM, Lahian A, Escobar A, England W, Chaluvadi S, O'Brien CA, Yaqoob F, Aisenberg WH, Porras-Paniagua M, Bennett ML, Davtyan H, Spitale RC, Blurton-Jones M, Bennett FC. PMID: 36584406.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. iScience. 2023 Jan 20; 26(1):105732. Reyes-Ortiz AM, Abud EM, Burns MS, Wu J, Hernandez SJ, McClure N, Wang KQ, Schulz CJ, Miramontes R, Lau A, Michael N, Miyoshi E, Van Vactor D, Reidling JC, Blurton-Jones M, Swarup V, Poon WW, Lim RG, Thompson LM. PMID: 36590162; PMCID: PMC9800269.
      View in: PubMed   Mentions: 2  
    19. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 11 02; 110(21):3458-3483. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brône B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, González B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. PMID: 36327895; PMCID: PMC9999291.
      View in: PubMed   Mentions: 261     Fields:    Translation:Cells
    20. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Rep. 2022 06 14; 39(11):110961. Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, Head E, Hume DA, Pridans C, Davtyan H, Swarup V, Blurton-Jones M. PMID: 35705056; PMCID: PMC9285116.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    21. Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls. Front Neurosci. 2022; 16:881713. Radhakrishnan H, Shabestari SK, Blurton-Jones M, Obenaus A, Stark CEL. PMID: 35720733; PMCID: PMC9204138.
      View in: PubMed   Mentions: 1  
    22. Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein. Int J Mol Sci. 2022 May 29; 23(11). Zagorski K, Chailyan G, Hovakimyan A, Antonyan T, Kiani Shabestari S, Petrushina I, Davtyan H, Cribbs DH, Blurton-Jones M, Masliah E, Agadjanyan MG, Ghochikyan A. PMID: 35682759; PMCID: PMC9181659.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife. 2022 02 22; 11. Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M, Cahalan MD. PMID: 35191835; PMCID: PMC8906810.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    24. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Alzheimers Dement. 2022 10; 18(10):1765-1778. Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, Landreth GE, Spitale RC, Blurton-Jones M, Davtyan H. PMID: 35142046; PMCID: PMC9360195.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies. NPJ Vaccines. 2022 Jan 10; 7(1):1. Kim C, Hovakimyan A, Zagorski K, Antonyan T, Petrushina I, Davtyan H, Chailyan G, Hasselmann J, Iba M, Adame A, Rockenstein E, Szabo M, Blurton-Jones M, Cribbs DH, Ghochikyan A, Masliah E, Agadjanyan MG. PMID: 35013319; PMCID: PMC8748802.
      View in: PubMed   Mentions: 9  
    26. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022 01; 11(1):e12183. You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. PMID: 35029059; PMCID: PMC8758831.
      View in: PubMed   Mentions: 32     Fields:    
    27. Human Induced Pluripotent Stem Cell-Derived Microglia (hiPSC-Microglia). Methods Mol Biol. 2022; 2454:473-482. McQuade A, Blurton-Jones M. PMID: 34773245.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Sci Transl Med. 2021 12; 13(622):eabg2919. Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pa?ca AM, Pa?ca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T. PMID: 34851695; PMCID: PMC9067636.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure. Adv Sci (Weinh). 2021 09; 8(18):e2101462. Chen X, Sun G, Tian E, Zhang M, Davtyan H, Beach TG, Reiman EM, Blurton-Jones M, Holtzman DM, Shi Y. PMID: 34337898; PMCID: PMC8456220.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    30. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Mol Neurodegener. 2021 07 23; 16(1):50. Claes C, Danhash EP, Hasselmann J, Chadarevian JP, Shabestari SK, England WE, Lim TE, Hidalgo JLS, Spitale RC, Davtyan H, Blurton-Jones M. PMID: 34301296; PMCID: PMC8305935.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    31. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron. 2021 07 21; 109(14):2275-2291.e8. Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. PMID: 34133945; PMCID: PMC8298293.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    32. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. J Exp Med. 2020 12 07; 217(12). Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, Xu H. PMID: 32941599; PMCID: PMC7953740.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2020 10 23; 11(1):5370. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 33097708; PMCID: PMC7584603.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    34. Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials. Neurobiol Dis. 2020 06; 139:104823. Petrushina I, Hovakimyan A, Harahap-Carrillo IS, Davtyan H, Antonyan T, Chailyan G, Kazarian K, Antonenko M, Jullienne A, Hamer MM, Obenaus A, King O, Zagorski K, Blurton-Jones M, Cribbs DH, Lander H, Ghochikyan A, Agadjanyan MG. PMID: 32119976; PMCID: PMC8772258.
      View in: PubMed   Mentions: 17     Fields:    
    35. Human iPSC-derived microglia: A growing toolset to study the brain's innate immune cells. Glia. 2020 04; 68(4):721-739. Hasselmann J, Blurton-Jones M. PMID: 31926038; PMCID: PMC7813153.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    36. Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. Alzheimers Res Ther. 2019 12 17; 11(1):107. Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. PMID: 31847886; PMCID: PMC6918571.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    37. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21198-21206. Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 31570577; PMCID: PMC6800331.
      View in: PubMed   Mentions: 12     Fields:    
    38. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Neuron. 2019 09 25; 103(6):1016-1033.e10. Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. PMID: 31375314; PMCID: PMC7138101.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    39. Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nat Commun. 2019 07 19; 10(1):3215. Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. PMID: 31324781; PMCID: PMC6642117.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    40. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports. 2019 03 05; 12(3):451-460. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. PMID: 30745035; PMCID: PMC6409424.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    41. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. J Mol Biol. 2019 04 19; 431(9):1805-1817. McQuade A, Blurton-Jones M. PMID: 30738892; PMCID: PMC6475606.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    42. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. 2019 05; 67(5):844-856. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. PMID: 30588668; PMCID: PMC7375697.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    43. Development and validation of a simplified method to generate human microglia from pluripotent stem cells. Mol Neurodegener. 2018 12 22; 13(1):67. McQuade A, Coburn M, Tu CH, Hasselmann J, Davtyan H, Blurton-Jones M. PMID: 30577865; PMCID: PMC6303871.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    44. Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia. Neurosci Res. 2018 Apr; 129:40-46. Nakazono T, Jun H, Blurton-Jones M, Green KN, Igarashi KM. PMID: 29438778; PMCID: PMC7059556.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    45. Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron. 2017 12 20; 96(6):1290-1302.e6. Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T. PMID: 29268096; PMCID: PMC5806703.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    46. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports. 2018 01 09; 10(1):58-72. Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. PMID: 29233555; PMCID: PMC5768890.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    47. MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency. Neurobiol Aging. 2017 11; 59:156-170. Davtyan H, Zagorski K, Petrushina I, Kazarian K, Goldberg NRS, Petrosyan J, Blurton-Jones M, Masliah E, Cribbs DH, Agadjanyan MG, Ghochikyan A. PMID: 28870518; PMCID: PMC5612893.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency. Mol Neurodegener. 2017 05 05; 12(1):33. Agadjanyan MG, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, Davis J, Bon C, Blurton-Jones M, Cribbs DH, Ghochikyan A. PMID: 28472993; PMCID: PMC5418694.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    49. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017 Apr 19; 94(2):278-293.e9. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. PMID: 28426964; PMCID: PMC5482419.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansAnimalsCells
    50. MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice. Vaccine. 2017 04 11; 35(16):2015-2024. Davtyan H, Chen WW, Zagorski K, Davis J, Petrushina I, Kazarian K, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. PMID: 28320590; PMCID: PMC5395280.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    51. Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice. Acta Neuropathol Commun. 2017 03 10; 5(1):21. Lakatos A, Goldberg NR, Blurton-Jones M. PMID: 28283027; PMCID: PMC5345195.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies. Stem Cells Transl Med. 2017 06; 6(6):1477-1490. Goldberg NRS, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M. PMID: 28225193; PMCID: PMC5464354.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    53. Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support. Neurochem Int. 2017 Jun; 106:94-100. Marsh SE, Blurton-Jones M. PMID: 28219641; PMCID: PMC5446923.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    54. Response to StemCells Inc. Stem Cell Reports. 2017 02 14; 8(2):195-197. Monuki ES, Anderson AJ, Blurton-Jones M, Cummings BJ. PMID: 28199827; PMCID: PMC5312268.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    55. HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease. Stem Cell Reports. 2017 02 14; 8(2):235-248. Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M. PMID: 28199828; PMCID: PMC5312253.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    56. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathol Commun. 2016 06 23; 4(1):63. Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M. PMID: 27339073; PMCID: PMC4918195.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    57. BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens. Nat Commun. 2016 05 26; 7:11725. White AO, Kramár EA, López AJ, Kwapis JL, Doan J, Saldana D, Davatolhagh MF, Alaghband Y, Blurton-Jones M, Matheos DP, Wood MA. PMID: 27226355; PMCID: PMC4894971.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    58. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain. 2016 Apr; 139(Pt 4):1265-81. Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN. PMID: 26921617; PMCID: PMC5006229.
      View in: PubMed   Mentions: 314     Fields:    Translation:AnimalsCells
    59. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1316-25. Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. PMID: 26884167; PMCID: PMC4780638.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCells
    60. Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism. Stem Cell Reports. 2015 Nov 10; 5(5):791-804. Goldberg NRS, Caesar J, Park A, Sedgh S, Finogenov G, Masliah E, Davis J, Blurton-Jones M. PMID: 26489892; PMCID: PMC4649255.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    61. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. 2015 Jul; 25(7):813-26. Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. PMID: 25530343; PMCID: PMC4722865.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    62. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2014 Apr 16; 5(2):46. Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. PMID: 25022790; PMCID: PMC4055090.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    63. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15. Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. PMID: 23747512; PMCID: PMC3730785.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    64. Concise review: Can stem cells be used to treat or model Alzheimer's disease? Stem Cells. 2012 Dec; 30(12):2612-8. Chen WW, Blurton-Jones M. PMID: 22997040; PMCID: PMC3508338.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    65. Soluble aβ promotes wild-type tau pathology in vivo. J Neurosci. 2012 Nov 28; 32(48):17345-50. Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM. PMID: 23197725; PMCID: PMC3586232.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    66. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem. 2012 Aug 31; 287(36):30317-27. Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, LaFerla FM. PMID: 22753410; PMCID: PMC3436283.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    67. Examining the mechanisms that link β-amyloid and α-synuclein pathologies. Alzheimers Res Ther. 2012; 4(2):11. Marsh SE, Blurton-Jones M. PMID: 22546279; PMCID: PMC4054672.
      View in: PubMed   Mentions: 46     Fields:    
    68. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem. 2011 Jul 08; 286(27):24264-74. Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. PMID: 21606494; PMCID: PMC3129207.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    69. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26; 30(21):7281-9. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. PMID: 20505094; PMCID: PMC3308018.
      View in: PubMed   Mentions: 251     Fields:    Translation:HumansAnimalsCells
    70. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010 Jul; 177(1):300-10. Koike MA, Green KN, Blurton-Jones M, Laferla FM. PMID: 20472896; PMCID: PMC2893673.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    71. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. PMID: 19633196; PMCID: PMC2715325.
      View in: PubMed   Mentions: 345     Fields:    Translation:AnimalsCells
    72. β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging. 2011 May; 32(5):821-33. Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. PMID: 19540623; PMCID: PMC3038182.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    73. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009 Apr; 34(1):163-77. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. PMID: 19320056; PMCID: PMC2948857.
      View in: PubMed   Mentions: 131     Fields:    Translation:AnimalsCells
    74. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. J Alzheimers Dis. 2009; 16(3):541-9. Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. PMID: 19276549.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    75. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. PMID: 17978032; PMCID: PMC6673368.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    76. Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Struct Funct. 2007 Sep; 212(2):133-48. Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE. PMID: 17764016.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    77. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging. 2008 Nov; 29(11):1607-18. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. PMID: 17544172; PMCID: PMC2664168.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    78. Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res. 2006 Dec; 3(5):437-48. Blurton-Jones M, Laferla FM. PMID: 17168643.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    79. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 01; 499(4):603-12. Blurton-Jones M, Tuszynski MH. PMID: 17029253.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    80. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007 Dec; 28(12):1821-33. Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. PMID: 17052803; PMCID: PMC2198930.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    81. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods. 2005 Aug; 2(8):599-605. Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL. PMID: 16094385; PMCID: PMC1558906.
      View in: PubMed   Mentions: 491     Fields:    Translation:AnimalsCells
    82. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15751224.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    83. Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol. 2004 Aug; 165(2):353-5. Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15277211; PMCID: PMC1618562.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    84. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619; PMCID: PMC437967.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansAnimalsCells
    85. Estrogen receptor immunoreactivity in the adult primate brain: neuronal distribution and association with p75, trkA, and choline acetyltransferase. J Comp Neurol. 1999 Mar 22; 405(4):529-42. Blurton-Jones MM, Roberts JA, Tuszynski MH. PMID: 10098943.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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