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Blurton-Jones, Mathew Mark

Title(s)Associate Professor, Neurobiology & Behavior
Phone(949) 824-5243
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    A novel platform for the investigation of human microglia
    NIH/NIDA RF1DA048813Aug 15, 2019 - Aug 14, 2022
    Role: Co-Principal Investigator
    Examining the role of adaptive immunity in Alzheimer's Disease pathogenesis
    NIH/NIA RF1AG055524Sep 15, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Manipulating DNA repair enzymes to examine the interactions between aging and Alzheimers disease with iPSC-derived microglia
    NIH/NIA R01AG056303Jul 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    The role of TREM2 in human microglial function and Alzheimer disease pathogenesis
    NIH/NIA RF1AG048099Sep 15, 2014 - Jun 30, 2019
    Role: Principal Investigator
    The Role of Beta-Amyloid Assembly States in Tau Pathology and Cognitive Decline
    NIH/NIA K01AG029378Apr 15, 2008 - Mar 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cadete Martini A, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019 Sep 30. PMID: 31570577.
      View in: PubMed
    2. Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Neuron. 2019 Jul 25. PMID: 31375314.
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    3. Rojo R, Raper A, Ozdemir DD, Lefevre L, Grabert K, Wollscheid-Lengeling E, Bradford B, Caruso M, Gazova I, Sánchez A, Lisowski ZM, Alves J, Molina-Gonzalez I, Davtyan H, Lodge RJ, Glover JD, Wallace R, Munro DAD, David E, Amit I, Miron VE, Priller J, Jenkins SJ, Hardingham GE, Blurton-Jones M, Mabbott NA, Summers KM, Hohenstein P, Hume DA, Pridans C. Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nat Commun. 2019 Jul 19; 10(1):3215. PMID: 31324781.
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    4. McQuade A, Blurton-Jones M. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. J Mol Biol. 2019 Apr 19; 431(9):1805-1817. PMID: 30738892.
      View in: PubMed
    5. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports. 2019 Mar 05; 12(3):451-460. PMID: 30745035.
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    6. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. 2019 05; 67(5):844-856. PMID: 30588668.
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    7. McQuade A, Coburn M, Tu CH, Hasselmann J, Davtyan H, Blurton-Jones M. Development and validation of a simplified method to generate human microglia from pluripotent stem cells. Mol Neurodegener. 2018 12 22; 13(1):67. PMID: 30577865.
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    8. Nakazono T, Jun H, Blurton-Jones M, Green KN, Igarashi KM. Gamma oscillations in the entorhinal-hippocampal circuit underlying memory and dementia. Neurosci Res. 2018 Apr; 129:40-46. PMID: 29438778.
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    9. Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T. Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron. 2017 12 20; 96(6):1290-1302.e6. PMID: 29268096.
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    10. Reidling JC, Relaño-Ginés A, Holley SM, Ochaba J, Moore C, Fury B, Lau A, Tran AH, Yeung S, Salamati D, Zhu C, Hatami A, Cepeda C, Barry JA, Kamdjou T, King A, Coleal-Bergum D, Franich NR, LaFerla FM, Steffan JS, Blurton-Jones M, Meshul CK, Bauer G, Levine MS, Chesselet MF, Thompson LM. Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports. 2018 01 09; 10(1):58-72. PMID: 29233555.
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    11. Davtyan H, Zagorski K, Petrushina I, Kazarian K, Goldberg NRS, Petrosyan J, Blurton-Jones M, Masliah E, Cribbs DH, Agadjanyan MG, Ghochikyan A. MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency. Neurobiol Aging. 2017 11; 59:156-170. PMID: 28870518.
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    12. Agadjanyan MG, Zagorski K, Petrushina I, Davtyan H, Kazarian K, Antonenko M, Davis J, Bon C, Blurton-Jones M, Cribbs DH, Ghochikyan A. Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency. Mol Neurodegener. 2017 05 05; 12(1):33. PMID: 28472993.
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    13. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017 Apr 19; 94(2):278-293.e9. PMID: 28426964.
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    14. Davtyan H, Chen WW, Zagorski K, Davis J, Petrushina I, Kazarian K, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice. Vaccine. 2017 04 11; 35(16):2015-2024. PMID: 28320590.
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    15. Lakatos A, Goldberg NR, Blurton-Jones M. Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice. Acta Neuropathol Commun. 2017 03 10; 5(1):21. PMID: 28283027.
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    16. Goldberg NRS, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M. Human Neural Progenitor Transplantation Rescues Behavior and Reduces a-Synuclein in a Transgenic Model of Dementia with Lewy Bodies. Stem Cells Transl Med. 2017 06; 6(6):1477-1490. PMID: 28225193.
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    17. Marsh SE, Blurton-Jones M. Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support. Neurochem Int. 2017 Jun; 106:94-100. PMID: 28219641.
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    18. Monuki ES, Anderson AJ, Blurton-Jones M, Cummings BJ. Response to StemCells Inc. Stem Cell Reports. 2017 02 14; 8(2):195-197. PMID: 28199827.
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    19. Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M. HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease. Stem Cell Reports. 2017 02 14; 8(2):235-248. PMID: 28199828.
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    20. Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathol Commun. 2016 06 23; 4(1):63. PMID: 27339073.
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    21. White AO, Kramár EA, López AJ, Kwapis JL, Doan J, Saldana D, Davatolhagh MF, Alaghband Y, Blurton-Jones M, Matheos DP, Wood MA. BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens. Nat Commun. 2016 05 26; 7:11725. PMID: 27226355.
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    22. Spangenberg EE, Lee RJ, Najafi AR, Rice RA, Elmore MR, Blurton-Jones M, West BL, Green KN. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-ß pathology. Brain. 2016 Apr; 139(Pt 4):1265-81. PMID: 26921617.
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    23. Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1316-25. PMID: 26884167.
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    24. Goldberg NRS, Caesar J, Park A, Sedgh S, Finogenov G, Masliah E, Davis J, Blurton-Jones M. Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism. Stem Cell Reports. 2015 Nov 10; 5(5):791-804. PMID: 26489892.
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    25. Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. 2015 Jul; 25(7):813-26. PMID: 25530343.
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    26. Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Res Ther. 2014 Apr 16; 5(2):46. PMID: 25022790.
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    27. Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15. PMID: 23747512.
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    28. Chen WW, Blurton-Jones M. Concise review: Can stem cells be used to treat or model Alzheimer's disease? Stem Cells. 2012 Dec; 30(12):2612-8. PMID: 22997040.
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    29. Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H, LaFerla FM. Soluble aß promotes wild-type tau pathology in vivo. J Neurosci. 2012 Nov 28; 32(48):17345-50. PMID: 23197725.
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    30. Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, LaFerla FM. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid. J Biol Chem. 2012 Aug 31; 287(36):30317-27. PMID: 22753410.
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    31. Marsh SE, Blurton-Jones M. Examining the mechanisms that link ß-amyloid and a-synuclein pathologies. Alzheimers Res Ther. 2012; 4(2):11. PMID: 22546279.
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    32. Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M. Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem. 2011 Jul 08; 286(27):24264-74. PMID: 21606494.
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    33. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26; 30(21):7281-9. PMID: 20505094.
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    34. Koike MA, Green KN, Blurton-Jones M, Laferla FM. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010 Jul; 177(1):300-10. PMID: 20472896.
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    35. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9. PMID: 19633196.
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    36. Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. ß-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging. 2011 May; 32(5):821-33. PMID: 19540623.
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    37. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis. 2009 Apr; 34(1):163-77. PMID: 19320056.
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    38. Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM. Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. J Alzheimers Dis. 2009; 16(3):541-9. PMID: 19276549.
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    39. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33. PMID: 17978032.
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    40. Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE. Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Struct Funct. 2007 Sep; 212(2):133-48. PMID: 17764016.
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    41. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging. 2008 Nov; 29(11):1607-18. PMID: 17544172.
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    42. Blurton-Jones M, Tuszynski MH. Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol. 2006 Dec 01; 499(4):603-12. PMID: 17029253.
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    43. Blurton-Jones M, Laferla FM. Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res. 2006 Dec; 3(5):437-48. PMID: 17168643.
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    44. Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007 Dec; 28(12):1821-33. PMID: 17052803.
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    45. Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods. 2005 Aug; 2(8):599-605. PMID: 16094385.
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    46. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. PMID: 15751224.
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    47. Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol. 2004 Aug; 165(2):353-5. PMID: 15277211.
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    48. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. PMID: 15232619.
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    49. Blurton-Jones M, Tuszynski MH. Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol. 2002 Oct 21; 452(3):276-87. PMID: 12353223.
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    50. Taber KH, Murphy DD, Blurton-Jones MM, Hurley RA. An update on estrogen: higher cognitive function, receptor mapping, neurotrophic effects. J Neuropsychiatry Clin Neurosci. 2001; 13(3):313-7. PMID: 11514636.
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    51. Blurton-Jones MM, Roberts JA, Tuszynski MH. Estrogen receptor immunoreactivity in the adult primate brain: neuronal distribution and association with p75, trkA, and choline acetyltransferase. J Comp Neurol. 1999 Mar 22; 405(4):529-42. PMID: 10098943.
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