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High Extracellular K+ Skews T-Cell Differentiation Towards Tumour Promoting Th2 and Treg Subsets. Eur J Immunol. 2024 Dec 09; e202451440.
Wong BHS, Poh ZS, Wei JTC, Amuthavalli K, Ho YS, Chen S, Mak SY, Bi X, Webster RD, Shelat VG, Chandy KG, Verma NK. PMID: 39651799.
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Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma. Nat Commun. 2024 Mar 08; 15(1):2113.
Liu M, Bertolazzi G, Sridhar S, Lee RX, Jaynes P, Mulder K, Syn N, Hoppe MM, Fan S, Peng Y, Thng J, Chua R, Batumalai Y, De Mel S, Poon L, Chan EHL, Lee J, Hue SS, Chang ST, Chuang SS, Chandy KG, Ye X, Pan-Hammarström Q, Ginhoux F, Chee YL, Ng SB, Tripodo C, Jeyasekharan AD. PMID: 38459052; PMCID: PMC10923916.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads. Channels (Austin). 2023 12; 17(1):2253104.
Chandy KG, Sanches K, Norton RS. PMID: 37695839; PMCID: PMC10496531.
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6 Fields:
Translation:
AnimalsCells
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Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics. J Chem Inf Model. 2023 05 22; 63(10):3043-3053.
Sanches K, Prypoten V, Chandy KG, Chalmers DK, Norton RS. PMID: 37143234.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint. EBioMedicine. 2022 Sep; 83:104216.
Verma NK, Wong BHS, Poh ZS, Udayakumar A, Verma R, Goh RKJ, Duggan SP, Shelat VG, Chandy KG, Grigoropoulos NF. PMID: 35986950; PMCID: PMC9403334.
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45 Fields:
Translation:
HumansCells
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Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels. Front Pharmacol. 2022; 13:924289.
Ong ST, Tyagi A, Chandy KG, Bhushan S. PMID: 35833027; PMCID: PMC9271579.
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5
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Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response. Cancers (Basel). 2022 Feb 26; 14(5).
Goggi JL, Khanapur S, Ramasamy B, Hartimath SV, Rong TJ, Cheng P, Tan YX, Yeo XY, Jung S, Goay SSM, Ong ST, Hwang YY, Chandy KG, Robins EG. PMID: 35267526; PMCID: PMC8909107.
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3
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Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc Natl Acad Sci U S A. 2022 02 01; 119(5).
Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG, Bhushan S. PMID: 35091471; PMCID: PMC8812516.
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16 Fields:
Translation:
HumansCells
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Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis. Front Pharmacol. 2021; 12:714841.
Markakis I, Charitakis I, Beeton C, Galani M, Repousi E, Aggeloglou S, Sfikakis PP, Pennington MW, Chandy KG, Poulopoulou C. PMID: 34630091; PMCID: PMC8495199.
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PubMed Mentions:
2
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Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3. Cell Discov. 2021 Jun 01; 7(1):39.
Liu S, Zhao Y, Dong H, Xiao L, Zhang Y, Yang Y, Ong ST, Chandy KG, Zhang L, Tian C. PMID: 34059645; PMCID: PMC8167131.
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PubMed Mentions:
13
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CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice. Front Immunol. 2020; 11:580968.
Her Z, Tan JHL, Lim YS, Tan SY, Chan XY, Tan WWS, Liu M, Yong KSM, Lai F, Ceccarello E, Zheng Z, Fan Y, Chang KTE, Sun L, Chang SC, Chin CL, Lee GH, Dan YY, Chan YS, Lim SG, Chan JKY, Chandy KG, Chen Q. PMID: 33013934; PMCID: PMC7516019.
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43 Fields:
Translation:
HumansAnimalsCells
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Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736.
Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. PMID: 32832873; PMCID: PMC7432667.
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PubMed Mentions:
11
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Contributions of natural products to ion channel pharmacology. Nat Prod Rep. 2020 05 01; 37(5):703-716.
Bajaj S, Ong ST, Chandy KG. PMID: 32065187.
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12 Fields:
Translation:
HumansAnimals
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Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. Bioelectricity. 2019 Sep 01; 1(3):169-179.
Ong ST, Ng AS, Ng XR, Zhuang Z, Wong BHS, Prasannan P, Kok YJ, Bi X, Shim H, Wulff H, Chandy KG, Verma NK. PMID: 34471819; PMCID: PMC8370284.
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PubMed Mentions:
19
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Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 05; 18(5):339-357.
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. PMID: 30728472; PMCID: PMC6499689.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimals
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 01; 118(2):200-212.
Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A. PMID: 29161243; PMCID: PMC5785745.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva. J Vis Exp. 2017 07 05; (125).
Bose T, Hou A, Lee R, Tong L, Chandy KG. PMID: 28715398; PMCID: PMC5608542.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Venom-derived peptide inhibitors of voltage-gated potassium channels. Neuropharmacology. 2017 Dec; 127:124-138.
Norton RS, Chandy KG. PMID: 28689025.
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PubMed Mentions:
28 Fields:
Translation:
Animals
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A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue. J Vis Exp. 2017 06 07; (124).
Hou A, Bose T, Chandy KG, Tong L. PMID: 28654074; PMCID: PMC5608287.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease. Curr Opin Chem Biol. 2017 Jun; 38:97-107.
Chandy KG, Norton RS. PMID: 28412597.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease. Sci Rep. 2017 03 27; 7:45312.
Bose T, Lee R, Hou A, Tong L, Chandy KG. PMID: 28345628; PMCID: PMC5366884.
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23 Fields:
Translation:
HumansCells
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International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev. 2017 01; 69(1):1-11.
Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. PMID: 28267675; PMCID: PMC11060434.
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PubMed Mentions:
53 Fields:
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HumansAnimalsCells
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Immunology: Channelling potassium to fight cancer. Nature. 2016 09 22; 537(7621):497-499.
Chandy KG, Norton RS. PMID: 27626384.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64.
Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. PMID: 24891519; PMCID: PMC4139903.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Blockade of Kv1.3 channels ameliorates radiation-induced brain injury. Neuro Oncol. 2014 Apr; 16(4):528-39.
Peng Y, Lu K, Li Z, Zhao Y, Wang Y, Hu B, Xu P, Shi X, Zhou B, Pennington M, Chandy KG, Tang Y. PMID: 24305723; PMCID: PMC3956348.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCellsPHPublic Health
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Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci. 2013 Oct 09; 33(41):16310-22.
Lioudyno MI, Birch AM, Tanaka BS, Sokolov Y, Goldin AL, Chandy KG, Hall JE, Alkire MT. PMID: 24107962; PMCID: PMC3792466.
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PubMed Mentions:
39 Fields:
Translation:
Animals
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Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2239-48.
Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. PMID: 23729813; PMCID: PMC3683782.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease. J Biol Chem. 2013 Mar 01; 288(9):6451-64.
Nguyen HM, Galea CA, Schmunk G, Smith BJ, Edwards RA, Norton RS, Chandy KG. PMID: 23300077; PMCID: PMC3585079.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82.
Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. PMID: 23090990; PMCID: PMC3494885.
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36 Fields:
Translation:
AnimalsCells
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Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. J Pharmacol Exp Ther. 2012 Sep; 342(3):642-53.
Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, Knapp B, Kentala D, Hansen Z, Pennington MW, Beeton C, Chandy KG, Iadonato SP. PMID: 22637724; PMCID: PMC3422530.
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65 Fields:
Translation:
HumansAnimalsCells
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Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. J Immunol. 2012 Jun 15; 188(12):5877-86.
Gocke AR, Lebson LA, Grishkan IV, Hu L, Nguyen HM, Whartenby KA, Chandy KG, Calabresi PA. PMID: 22581856; PMCID: PMC3370138.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med. 2012 Jul; 4(7):577-93.
Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabò I. PMID: 22496117; PMCID: PMC3407946.
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PubMed Mentions:
82 Fields:
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HumansAnimalsCells
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Therapeutic potential of peptide toxins that target ion channels. Inflamm Allergy Drug Targets. 2011 Oct; 10(5):322-42.
Beraud E, Chandy KG. PMID: 21745182.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46.
Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. PMID: 21867724; PMCID: PMC3397671.
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PubMed Mentions:
94 Fields:
Translation:
AnimalsCells
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18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies. J Nucl Med. 2011 Jul; 52(7):1125-32.
Garcia A, Mirbolooki MR, Constantinescu C, Pan ML, Sevrioukov E, Milne N, Wang PH, Lakey J, Chandy KG, Mukherjee J. PMID: 21680697.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334.
Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. PMID: 21629267; PMCID: PMC3133923.
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PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010 Mar 19; 285(12):9124-36.
Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. PMID: 19965868; PMCID: PMC2838332.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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The functional network of ion channels in T lymphocytes. Immunol Rev. 2009 Sep; 231(1):59-87.
Cahalan MD, Chandy KG. PMID: 19754890; PMCID: PMC3133616.
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PubMed Mentions:
313 Fields:
Translation:
HumansAnimalsCells
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Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets. 2009 Aug; 13(8):909-24.
Rangaraju S, Chi V, Pennington MW, Chandy KG. PMID: 19538097.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr; 75(4):762-73.
Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. PMID: 19122005; PMCID: PMC2684922.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14.
Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. PMID: 18835197; PMCID: PMC2732399.
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PubMed Mentions:
119 Fields:
Translation:
AnimalsCells
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The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008 Sep; 118(9):3025-37.
Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. PMID: 18688283; PMCID: PMC2496961.
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PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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Imaging effector memory T cells in the ear after induction of adoptive DTH. J Vis Exp. 2008 Aug 14; (18).
Matheu MP, Beeton C, Parker I, Chandy KG, D Cahalan M. PMID: 19066497; PMCID: PMC3253563.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Isolation of mononuclear cells from the central nervous system of rats with EAE. J Vis Exp. 2007; (10):527.
Beeton C, Chandy KG. PMID: 18989401; PMCID: PMC2557079.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11; 283(2):988-97.
Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS. PMID: 17984097.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Preparing T cell growth factor from rat splenocytes. J Vis Exp. 2007; (10):402.
Beeton C, Chandy KG. PMID: 18989399; PMCID: PMC2557076.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Induction and monitoring of adoptive delayed-type hypersensitivity in rats. J Vis Exp. 2007 Oct 01; (8).
Beeton C, Chandy KG. PMID: 19252470; PMCID: PMC2956222.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Immunohistochemistry: paraffin sections using the Vectastain ABC kit from vector labs. J Vis Exp. 2007; (8):308.
Chi V, Chandy KG. PMID: 18989415; PMCID: PMC2562491.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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Enrichment of NK cells from human blood with the RosetteSep kit from StemCell technologies. J Vis Exp. 2007; (8):326.
Beeton C, Chandy KG. PMID: 18989426; PMCID: PMC2562500.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Drawing blood from rats through the saphenous vein and by cardiac puncture. J Vis Exp. 2007; (7):266.
Beeton C, Garcia A, Chandy KG. PMID: 18989437; PMCID: PMC2565848.
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PubMed Mentions:
32 Fields:
Translation:
Animals
-
Induction and monitoring of active delayed type hypersensitivity (DTH) in rats. J Vis Exp. 2007; (6):237.
Beeton C, Chandy KG. PMID: 18997885; PMCID: PMC2557114.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis. J Vis Exp. 2007; (5):224.
Beeton C, Garcia A, Chandy KG. PMID: 18979022; PMCID: PMC2557091.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Mouse adrenal chromaffin cell isolation. J Vis Exp. 2007 Jan 05; (2):129.
Kolski-Andreaco A, Cai H, Currle DS, Chandy KG, Chow RH. PMID: 18830430; PMCID: PMC2532942.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9.
Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564; PMCID: PMC1859943.
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PubMed Mentions:
250 Fields:
Translation:
HumansAnimalsCells
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Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist. 2005 Dec; 11(6):550-62.
Beeton C, Chandy KG. PMID: 16282596.
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PubMed Mentions:
53 Fields:
Translation:
HumansAnimalsCells
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International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):463-72.
Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. PMID: 16382103.
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PubMed Mentions:
181 Fields:
Translation:
HumansAnimals
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International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):473-508.
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. PMID: 16382104.
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PubMed Mentions:
382 Fields:
Translation:
HumansAnimals
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The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9.
Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. PMID: 16043714; PMCID: PMC1182417.
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PubMed Mentions:
93 Fields:
Translation:
HumansCells
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Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81.
Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. PMID: 15665253; PMCID: PMC4275123.
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PubMed Mentions:
111 Fields:
Translation:
HumansAnimalsCells
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K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004 Jul 15; 173(2):776-86.
Wulff H, Knaus HG, Pennington M, Chandy KG. PMID: 15240664.
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PubMed Mentions:
89 Fields:
Translation:
HumansCells
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Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74.
Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG. PMID: 15155830.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9.
Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495; PMCID: PMC2749963.
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PubMed Mentions:
190 Fields:
Translation:
HumansCells
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SKCa channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons. J Neurosci. 2004 Apr 07; 24(14):3537-42.
Villalobos C, Shakkottai VG, Chandy KG, Michelhaugh SK, Andrade R. PMID: 15071101; PMCID: PMC6729743.
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62 Fields:
Translation:
HumansAnimalsCells
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Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004 Feb; 113(4):582-90.
Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. PMID: 14966567; PMCID: PMC338266.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6.
Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology. PMID: 14657415.
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128 Fields:
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SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem. 2004 Feb 20; 279(8):6893-904.
Kolski-Andreaco A, Tomita H, Shakkottai VG, Gutman GA, Cahalan MD, Gargus JJ, Chandy KG. PMID: 14638680.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):640-7.
Wulff H, Beeton C, Chandy KG. PMID: 14579513.
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PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 02; 108(9):1119-25.
Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. PMID: 12939222.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13.
Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. PMID: 12782673; PMCID: PMC156104.
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PubMed Mentions:
206 Fields:
Translation:
HumansAnimalsCells
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Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. Mol Psychiatry. 2003 May; 8(5):524-35, 460.
Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. PMID: 12808432.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37.
Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3. Biochemistry. 2002 Oct 08; 41(40):11963-71.
Lanigan MD, Kalman K, Lefievre Y, Pennington MW, Chandy KG, Norton RS. PMID: 12356296.
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PubMed Mentions:
27 Fields:
Translation:
Cells
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Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan; 10(1):36-43.
Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. PMID: 11896454.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800.
Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7.
Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451; PMCID: PMC61146.
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PubMed Mentions:
135 Fields:
Translation:
AnimalsCells
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Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001 Sep; 39(9):1269-76.
Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. PMID: 11384714.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16; 276(46):43145-51.
Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. PMID: 11527975.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001 Jul; 21(4):235-52.
Cahalan MD, Wulff H, Chandy KG. PMID: 11506193.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5.
Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
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PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. J Biol Chem. 2001 Jul 27; 276(30):27753-6.
Miller MJ, Rauer H, Tomita H, Rauer H, Gargus JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 11395478.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13; 276(15):12249-56.
Fanger CM, Rauer H, Neben AL, Miller MJ, Rauer H, Wulff H, Rosa JC, Ganellin CR, Chandy KG, Cahalan MD. PMID: 11278890.
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PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem. 2000 Nov 24; 275(47):37137-49.
Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. PMID: 10961988.
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PubMed Mentions:
178 Fields:
Translation:
HumansCells
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Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 07 05; 97(14):8151-6.
Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437; PMCID: PMC16685.
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PubMed Mentions:
272 Fields:
Translation:
HumansCells
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Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels. J Biol Chem. 2000 Jan 14; 275(2):1201-8.
Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG. PMID: 10625664.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin. Biochemistry. 1999 Nov 02; 38(44):14549-58.
Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS. PMID: 10545177.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci. 1999 Nov; 20(11):444-7.
Tytgat J, Chandy KG, Garcia ML, Gutman GA, Martin-Eauclaire MF, van der Walt JJ, Possani LD. PMID: 10542442.
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PubMed Mentions:
91 Fields:
Translation:
Cells
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Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21. Am J Med Genet. 1999 Aug 20; 88(4):348-51.
Antonarakis SE, Blouin JL, Lasseter VK, Gehrig C, Radhakrishna U, Nestadt G, Housman DE, Kazazian HH, Kalman K, Gutman G, Fantino E, Chandy KG, Gargus JJ, Pulver AE. PMID: 10402501.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30; 274(31):21885-92.
Rauer H, Pennington M, Cahalan M, Chandy KG. PMID: 10419508.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry. 1999 May; 4(3):254-60.
Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy KG, Gargus JJ, Gutman GA, Navon R. PMID: 10395215.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr; 126(8):1707-16.
Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG. PMID: 10372812; PMCID: PMC1565958.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem. 1999 Feb 26; 274(9):5746-54.
Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J. PMID: 10026195.
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PubMed Mentions:
107 Fields:
Translation:
HumansAnimalsCells
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ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. 1998 Dec 04; 273(49):32697-707.
Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. PMID: 9830012.
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PubMed Mentions:
92 Fields:
Translation:
HumansAnimalsCells
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Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia. Biochem Biophys Res Commun. 1998 Oct 20; 251(2):662-5.
Li T, Hu X, Chandy KG, Fantino E, Kalman K, Gutman G, Gargus JJ, Freeman B, Murray RM, Dawson E, Liu X, Bruinvels AT, Sham PC, Collier DA. PMID: 9792831.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Two-dimensional crystallization and projection structure of KcsA potassium channel. J Mol Biol. 1998 Sep 18; 282(2):211-6.
Li HL, Sui HX, Ghanshani S, Lee S, Walian PJ, Wu CL, Chandy KG, Jap BK. PMID: 9735281.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J Biol Chem. 1998 Aug 07; 273(32):20109-13.
Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA. PMID: 9685353.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. Genomics. 1998 Jul 01; 51(1):160-1.
Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG. PMID: 9693050.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Mol Psychiatry. 1998 May; 3(3):266-9.
Bowen T, Guy CA, Craddock N, Cardno AG, Williams NM, Spurlock G, Murphy KC, Jones LA, Gray M, Sanders RD, McCarthy G, Chandy KG, Fantino E, Kalman K, Gutman GA, Gargus JJ, Williams J, McGuffin P, Owen MJ, O'Donovan MC. PMID: 9672903.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem. 1998 Mar 06; 273(10):5851-7.
Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. PMID: 9488722.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol. 1998 Jan 15; 506 ( Pt 2):291-301.
Jäger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S. PMID: 9490854; PMCID: PMC2230732.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry. 1998 Jan; 3(1):32-7.
Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH, Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ. PMID: 9491810.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Ion channels in the immune system as targets for immunosuppression. Curr Opin Biotechnol. 1997 Dec; 8(6):749-56.
Cahalan MD, Chandy KG. PMID: 9425667.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J Biol Chem. 1997 Oct 24; 272(43):26899-904.
Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH. PMID: 9341123.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Purification, visualization, and biophysical characterization of Kv1.3 tetramers. J Biol Chem. 1997 Jan 24; 272(4):2389-95.
Spencer RH, Sokolov Y, Li H, Takenaka B, Milici AJ, Aiyar J, Nguyen A, Park H, Jap BK, Hall JE, Gutman GA, Chandy KG. PMID: 8999950.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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The signature sequence of voltage-gated potassium channels projects into the external vestibule. J Biol Chem. 1996 Dec 06; 271(49):31013-6.
Aiyar J, Rizzi JP, Gutman GA, Chandy KG. PMID: 8940091.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec; 50(6):1672-9.
Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG. PMID: 8967992.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene. J Biol Chem. 1996 Jun 28; 271(26):15629-34.
Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG. PMID: 8663090.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway. Biophys J. 1994 Dec; 67(6):2261-4.
Aiyar J, Nguyen AN, Chandy KG, Grissmer S. PMID: 7696467; PMCID: PMC1225609.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun; 45(6):1227-34.
Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. PMID: 7517498.
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PubMed Mentions:
306 Fields:
Translation:
AnimalsCells
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Nomenclature for mammalian potassium channel genes. Trends Pharmacol Sci. 1993 Dec; 14(12):434.
Chandy KG, Gutman GA. PMID: 8122319.
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PubMed Mentions:
22 Fields:
Translation:
Animals
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Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1571-8.
Aiyar J, Grissmer S, Chandy KG. PMID: 7506490.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Immunological Identification of the Shaker-Related Kv1.3 Potassium Channel Protein in T and B Lymphocytes, and Detection of Related Proteins in Flies and Yeast Biochem Biophys Res Commun. 1993 02 26; 191(1):201-6.
Spencer RH, Chandy KG, Gutman GA. PMID: 8447822.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol Biol Evol. 1993 Jan; 10(1):221-42.
Strong M, Chandy KG, Gutman GA. PMID: 7680747.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimals
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The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells. J Biol Chem. 1992 Oct 15; 267(29):20971-9.
Grissmer S, Ghanshani S, Dethlefs B, McPherson JD, Wasmuth JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 1400413.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Induction of thymus-reestablishing lymphoid tumors by a murine leukemia virus carrying the avian v-myc oncogene. Thymus. 1992 Aug; 20(1):47-61.
Spencer RH, Brightman BK, Trepp DJ, Fan H, Chandy KG. PMID: 1325692.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb; 12(2):190-6.
Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, Chandy KG. PMID: 1740329.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Simplified gene nomenclature. Nature. 1991 Jul 04; 352(6330):26.
Chandy KG. PMID: 2062374.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimals
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Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9411-5.
Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG. PMID: 2251283; PMCID: PMC55175.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels. J Immunol. 1990 Oct 01; 145(7):2105-9.
Grissmer S, Hanson DC, Natoli EJ, Cahalan MD, Chandy KG. PMID: 1975826.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells. Eur J Immunol. 1990 Apr; 20(4):747-51.
Chandy KG, Cahalan MD, Grissmer S. PMID: 1971790.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23; 247(4945):973-5.
Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA. PMID: 2305265.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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A T lymphoid cell line responds to a thymic stromal cell line by expression of Thy-1 and CD4. J Immunol. 1989 Nov 01; 143(9):2775-82.
Brightman BK, Chandy KG, Spencer RH, Fan H. PMID: 2572643.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Characterization of lymphoid tumors induced by a recombinant murine retrovirus carrying the avian v-myc oncogene. Identification of novel (B-lymphoid) tumors in the thymus. J Immunol. 1988 Oct 15; 141(8):2844-54.
Brightman BK, Chandy KG, Spencer RH, Gupta S, Pattengale PK, Fan H. PMID: 2902139.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases? J Immunol. 1988 Aug 15; 141(4):1137-42.
Grissmer S, Cahalan MD, Chandy KG. PMID: 2456342.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Interferon responsiveness of natural killer cells in type I human diabetes. Diabetes Res. 1988 Jan; 7(1):49-52.
Negishi K, Gupta S, Chandy KG, Waldeck N, Kershnar A, Buckingham B, Charles MA. PMID: 3402165.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Interleukin-2-like activity in injured rat brain. Neurochem Res. 1987 Aug; 12(8):723-7.
Nieto-Sampedro M, Chandy KG. PMID: 3114659.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Characterization of a preleukemic state induced by Moloney murine leukemia virus: evidence for two infection events during leukemogenesis. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4875-9.
Davis BR, Brightman BK, Chandy KG, Fan H. PMID: 3474632; PMCID: PMC305208.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Two types of potassium channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):379-404.
Decoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2435844; PMCID: PMC2215902.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):405-20.
Decoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2435845; PMCID: PMC2215901.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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Ion channels in T lymphocytes. Adv Exp Med Biol. 1987; 213:85-101.
Cahalan MD, Chandy KG, DeCoursey TE, Gupta S, Lewis RS, Sutro JB. PMID: 2442978.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Effects of nonleukemogenic and wild-type Moloney murine leukemia virus on lymphoid cells in vivo: identification of a preleukemic shift in thymocyte subpopulations. J Virol. 1986 Nov; 60(2):423-30.
Davis BR, Chandy KG, Brightman BK, Gupta S, Fan H. PMID: 3490580; PMCID: PMC288909.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation. Science. 1986 Sep 12; 233(4769):1197-200.
Chandy KG, DeCoursey TE, Fischbach M, Talal N, Cahalan MD, Gupta S. PMID: 2426784.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Voltage-dependent ion channels in T-lymphocytes. J Neuroimmunol. 1985 Nov; 10(1):71-95.
DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2414315.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Electroimmunology: the physiologic role of ion channels in the immune system. J Immunol. 1985 Aug; 135(2 Suppl):787s-791s.
Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2409167.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Acute effects of dialysis on T lymphocytes in patients with end-stage renal disease. J Clin Lab Immunol. 1985 Jul; 17(3):119-24.
Chandy KG, Pahl M, Vaziri ND, Gupta S. PMID: 3930749.
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Translation:
HumansCells
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A voltage-gated potassium channel in human T lymphocytes. J Physiol. 1985 Jan; 358:197-237.
Cahalan MD, Chandy KG, DeCoursey TE, Gupta S. PMID: 2580081; PMCID: PMC1193339.
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PubMed Mentions:
181 Fields:
Translation:
HumansCells
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Ion channels in lymphocytes. J Clin Immunol. 1985 Jan; 5(1):1-6.
Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2579969.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus. J Clin Immunol. 1984 Nov; 4(6):424-8.
Chandy KG, Charles AM, Kershnar A, Buckingham B, Waldeck N, Gupta S. PMID: 6239872.
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13 Fields:
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HumansCells
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Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med. 1984 Aug 01; 160(2):369-85.
Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S. PMID: 6088661; PMCID: PMC2187449.
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105 Fields:
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HumansCells
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Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984 Feb 2-8; 307(5950):465-8.
DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 6320007.
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245 Fields:
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HumansCells
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Deficiency of monoclonal antibody (Leu 7) defined NK cells in newly diagnosed insulin-dependent diabetes mellitus. Immunol Lett. 1984; 8(2):89-91.
Chandy KG, Charles MA, Buckingham B, Waldeck N, Kershnar A, Gupta S. PMID: 6746020.
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8 Fields:
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HumansCells
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Serum secretory component: a potential marker of biliary obstruction. Clin Chim Acta. 1983 Sep 15; 133(1):65-73.
Farris MA, Chandy KG, Ashdown K, Elias E, Burnett D. PMID: 6627677.
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3 Fields:
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Humans
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Dual role of the liver in regulating circulating polymeric IgA in man: studies on patients with liver disease. Clin Exp Immunol. 1983 Apr; 52(1):207-18.
Chandy KG, Hübscher SG, Elias E, Berg J, Khan M, Burnett D. PMID: 6345033; PMCID: PMC1535560.
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10 Fields:
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HumansCells
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Evidence for a single-chain structure of native human ceruloplasmin using sodium dodecyl sulfate-polyacrylamide-crossed immunoelectrophoresis. Anal Biochem. 1983 Feb 01; 128(2):317-22.
Burnett D, Chandy KG. PMID: 6846808.
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Humans
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Viral antibody titres in non-systemic glomerular disease. Indian J Med Res. 1982 Oct; 76:504-7.
Date A, Shastry JC, Chandy KG, John TJ. PMID: 6295929.
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HumansCells
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Relationship between serum viscosity and intravascular IgA polymer concentration in IgA myeloma. Clin Exp Immunol. 1981 Dec; 46(3):653-61.
Chandy KG, Stockley RA, Leonard RC, Crockson RA, Burnett D, MacLennan IC. PMID: 7337982; PMCID: PMC1536291.
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3 Fields:
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Humans
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Abnormalities of the immune system in patients with chyluria. Br J Urol. 1981 Aug; 53(4):384-6.
Date A, John TJ, Chandy KG, Rajagopalan MS, Vaska PH, Pandey AP, Shastry JC. PMID: 7260554.
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7 Fields:
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Humans
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The potential toxicity of excessive polyunsaturated fats (an experimental study). J Assoc Physicians India. 1981 Feb; 29(2):95-9.
Chandy KG, Uthaman B, Balasubramaniam AS, Cherian G. PMID: 7263607.
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Animals
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The estimation of Stokes radius for secretory immunoglobulin A, using thin-layer chromatography followed by crossed immunoelectrophoresis. Hoppe Seylers Z Physiol Chem. 1980 Dec; 361(12):1855-7.
Chandy KG, Stockley RA, Burnett D. PMID: 7461611.
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1 Fields:
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Humans
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Coxsackieviruses and chronic valvular heart disease. Am Heart J. 1980 Oct; 100(4):578-80.
Chandy KG, John TJ, Cherian G. PMID: 7415944.
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2 Fields:
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HumansAnimals
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Evidence for natural infection with group B in coxsackieviruses in bonnet monkeys. J Med Primatol. 1980; 9(5):323-4.
Chandy KG, Mukundan P, John TJ. PMID: 6255160.
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1 Fields:
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AnimalsCells
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Coxsackie B antibodies in "rheumatic" valvular heart-disease. Lancet. 1979 Feb 17; 1(8112):381.
Chandy KG, John TJ, Mukundan P, Cherian G. PMID: 85028.
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3 Fields:
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HumansCells