K George Chandy

Title(s)Professor Emeritus, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5865
vCardDownload vCard

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736. Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. PMID: 32832873.
      View in: PubMed   Mentions:
    2. Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 05; 18(5):339-357. Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. PMID: 30728472.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    3. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 01; 118(2):200-212. Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A. PMID: 29161243.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    4. Venom-derived peptide inhibitors of voltage-gated potassium channels. Neuropharmacology. 2017 Dec; 127:124-138. Norton RS, Chandy KG. PMID: 28689025.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    5. Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease. Curr Opin Chem Biol. 2017 Jun; 38:97-107. Chandy KG, Norton RS. PMID: 28412597.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    6. International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev. 2017 01; 69(1):1-11. Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. PMID: 28267675.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    7. Immunology: Channelling potassium to fight cancer. Nature. 2016 09 22; 537(7621):497-499. Chandy KG, Norton RS. PMID: 27626384.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    8. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64. Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. PMID: 24891519.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. Blockade of Kv1.3 channels ameliorates radiation-induced brain injury. Neuro Oncol. 2014 Apr; 16(4):528-39. Peng Y, Lu K, Li Z, Zhao Y, Wang Y, Hu B, Xu P, Shi X, Zhou B, Pennington M, Chandy KG, Tang Y. PMID: 24305723.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2239-48. Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. PMID: 23729813.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    11. Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease. J Biol Chem. 2013 Mar 01; 288(9):6451-64. Nguyen HM, Galea CA, Schmunk G, Smith BJ, Edwards RA, Norton RS, Chandy KG. PMID: 23300077.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Modulation of voltage-gated K+ channels by the sodium channel ß1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82. Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. PMID: 23090990.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    13. Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. J Pharmacol Exp Ther. 2012 Sep; 342(3):642-53. Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, Knapp B, Kentala D, Hansen Z, Pennington MW, Beeton C, Chandy KG, Iadonato SP. PMID: 22637724.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    14. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46. Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. PMID: 21867724.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    15. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. PMID: 21629267.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    16. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010 Mar 19; 285(12):9124-36. Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. PMID: 19965868.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    17. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009 Sep; 231(1):59-87. Cahalan MD, Chandy KG. PMID: 19754890.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimalsCells
    18. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets. 2009 Aug; 13(8):909-24. Rangaraju S, Chi V, Pennington MW, Chandy KG. PMID: 19538097.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    19. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr; 75(4):762-73. Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. PMID: 19122005.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    20. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. PMID: 18835197.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    21. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008 Sep; 118(9):3025-37. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. PMID: 18688283.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    22. Imaging effector memory T cells in the ear after induction of adoptive DTH. J Vis Exp. 2008 Aug 14; (18). Matheu MP, Beeton C, Parker I, Chandy KG, D Cahalan M. PMID: 19066497.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Isolation of mononuclear cells from the central nervous system of rats with EAE. J Vis Exp. 2007; (10):527. Beeton C, Chandy KG. PMID: 18989401.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11; 283(2):988-97. Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS. PMID: 17984097.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    25. Preparing T cell growth factor from rat splenocytes. J Vis Exp. 2007; (10):402. Beeton C, Chandy KG. PMID: 18989399.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Enrichment of NK cells from human blood with the RosetteSep kit from StemCell technologies. J Vis Exp. 2007; (8):326. Beeton C, Chandy KG. PMID: 18989426.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Immunohistochemistry: paraffin sections using the Vectastain ABC kit from vector labs. J Vis Exp. 2007; (8):308. Chi V, Chandy KG. PMID: 18989415.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    28. Induction and monitoring of adoptive delayed-type hypersensitivity in rats. J Vis Exp. 2007 Oct 01; (8). Beeton C, Chandy KG. PMID: 19252470.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. Drawing blood from rats through the saphenous vein and by cardiac puncture. J Vis Exp. 2007; (7):266. Beeton C, Garcia A, Chandy KG. PMID: 18989437.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    30. Induction and monitoring of active delayed type hypersensitivity (DTH) in rats. J Vis Exp. 2007; (6):237. Beeton C, Chandy KG. PMID: 18997885.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis. J Vis Exp. 2007; (5):224. Beeton C, Garcia A, Chandy KG. PMID: 18979022.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    32. Mouse adrenal chromaffin cell isolation. J Vis Exp. 2007 Jan 05; (2):129. Kolski-Andreaco A, Cai H, Currle DS, Chandy KG, Chow RH. PMID: 18830430.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    34. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):463-72. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. PMID: 16382103.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimals
    35. Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist. 2005 Dec; 11(6):550-62. Beeton C, Chandy KG. PMID: 16282596.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    36. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):473-508. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. PMID: 16382104.
      View in: PubMed   Mentions: 304     Fields:    Translation:HumansAnimals
    37. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. PMID: 16043714.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    38. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81. Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. PMID: 15665253.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    39. K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004 Jul 15; 173(2):776-86. Wulff H, Knaus HG, Pennington M, Chandy KG. PMID: 15240664.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    40. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74. Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG. PMID: 15155830.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    41. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    42. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004 Feb; 113(4):582-90. Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. PMID: 14966567.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    43. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology . PMID: 14657415.
      View in: PubMed   Mentions: 97     Fields:    
    44. SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem. 2004 Feb 20; 279(8):6893-904. Kolski-Andreaco A, Tomita H, Shakkottai VG, Gutman GA, Cahalan MD, Gargus JJ, Chandy KG. PMID: 14638680.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    45. Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):640-7. Wulff H, Beeton C, Chandy KG. PMID: 14579513.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    46. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 02; 108(9):1119-25. Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. PMID: 12939222.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    47. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. PMID: 12782673.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    48. Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. Mol Psychiatry. 2003 May; 8(5):524-35, 460. Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. PMID: 12808432.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    49. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    50. Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3. Biochemistry. 2002 Oct 08; 41(40):11963-71. Lanigan MD, Kalman K, Lefievre Y, Pennington MW, Chandy KG, Norton RS. PMID: 12356296.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    51. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan; 10(1):36-43. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. PMID: 11896454.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    52. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    53. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    54. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001 Sep; 39(9):1269-76. Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. PMID: 11384714.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    55. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16; 276(46):43145-51. Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. PMID: 11527975.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    56. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001 Jul; 21(4):235-52. Cahalan MD, Wulff H, Chandy KG. PMID: 11506193.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    57. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5. Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    58. Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. J Biol Chem. 2001 Jul 27; 276(30):27753-6. Miller MJ, Rauer H, Tomita H, Rauer H, Gargus JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 11395478.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    59. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13; 276(15):12249-56. Fanger CM, Rauer H, Neben AL, Miller MJ, Rauer H, Wulff H, Rosa JC, Ganellin CR, Chandy KG, Cahalan MD. PMID: 11278890.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    60. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem. 2000 Nov 24; 275(47):37137-49. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. PMID: 10961988.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansCells
    61. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8151-6. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansCells
    62. Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels. J Biol Chem. 2000 Jan 14; 275(2):1201-8. Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG. PMID: 10625664.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    63. Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin. Biochemistry. 1999 Nov 02; 38(44):14549-58. Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS. PMID: 10545177.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    64. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci. 1999 Nov; 20(11):444-7. Tytgat J, Chandy KG, Garcia ML, Gutman GA, Martin-Eauclaire MF, van der Walt JJ, Possani LD. PMID: 10542442.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    65. Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21. Am J Med Genet. 1999 Aug 20; 88(4):348-51. Antonarakis SE, Blouin JL, Lasseter VK, Gehrig C, Radhakrishna U, Nestadt G, Housman DE, Kazazian HH, Kalman K, Gutman G, Fantino E, Chandy KG, Gargus JJ, Pulver AE. PMID: 10402501.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    66. Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30; 274(31):21885-92. Rauer H, Pennington M, Cahalan M, Chandy KG. PMID: 10419508.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    67. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry. 1999 May; 4(3):254-60. Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy KG, Gargus JJ, Gutman GA, Navon R. PMID: 10395215.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    68. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr; 126(8):1707-16. Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG. PMID: 10372812.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    69. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem. 1999 Feb 26; 274(9):5746-54. Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J. PMID: 10026195.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    70. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. 1998 Dec 04; 273(49):32697-707. Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. PMID: 9830012.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    71. Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia. Biochem Biophys Res Commun. 1998 Oct 20; 251(2):662-5. Li T, Hu X, Chandy KG, Fantino E, Kalman K, Gutman G, Gargus JJ, Freeman B, Murray RM, Dawson E, Liu X, Bruinvels AT, Sham PC, Collier DA. PMID: 9792831.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    72. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J Biol Chem. 1998 Aug 07; 273(32):20109-13. Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA. PMID: 9685353.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    73. Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. Genomics. 1998 Jul 01; 51(1):160-1. Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG. PMID: 9693050.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    74. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Mol Psychiatry. 1998 May; 3(3):266-9. Bowen T, Guy CA, Craddock N, Cardno AG, Williams NM, Spurlock G, Murphy KC, Jones LA, Gray M, Sanders RD, McCarthy G, Chandy KG, Fantino E, Kalman K, Gutman GA, Gargus JJ, Williams J, McGuffin P, Owen MJ, O'Donovan MC. PMID: 9672903.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    75. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem. 1998 Mar 06; 273(10):5851-7. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. PMID: 9488722.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    76. Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol. 1998 Jan 15; 506 ( Pt 2):291-301. Jäger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S. PMID: 9490854.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    77. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry. 1998 Jan; 3(1):32-7. Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH, Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ. PMID: 9491810.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    78. Ion channels in the immune system as targets for immunosuppression. Curr Opin Biotechnol. 1997 Dec; 8(6):749-56. Cahalan MD, Chandy KG. PMID: 9425667.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    79. Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J Biol Chem. 1997 Oct 24; 272(43):26899-904. Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH. PMID: 9341123.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    80. Purification, visualization, and biophysical characterization of Kv1.3 tetramers. J Biol Chem. 1997 Jan 24; 272(4):2389-95. Spencer RH, Sokolov Y, Li H, Takenaka B, Milici AJ, Aiyar J, Nguyen A, Park H, Jap BK, Hall JE, Gutman GA, Chandy KG. PMID: 8999950.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    81. The signature sequence of voltage-gated potassium channels projects into the external vestibule. J Biol Chem. 1996 Dec 06; 271(49):31013-6. Aiyar J, Rizzi JP, Gutman GA, Chandy KG. PMID: 8940091.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    82. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec; 50(6):1672-9. Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG. PMID: 8967992.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    83. Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene. J Biol Chem. 1996 Jun 28; 271(26):15629-34. Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG. PMID: 8663090.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    84. The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway. Biophys J. 1994 Dec; 67(6):2261-4. Aiyar J, Nguyen AN, Chandy KG, Grissmer S. PMID: 7696467.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    85. Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun; 45(6):1227-34. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. PMID: 7517498.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    86. Nomenclature for mammalian potassium channel genes. Trends Pharmacol Sci. 1993 Dec; 14(12):434. Chandy KG, Gutman GA. PMID: 8122319.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    87. Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1571-8. Aiyar J, Grissmer S, Chandy KG. PMID: 7506490.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    88. Immunological identification of the Shaker-related Kv1.3 potassium channel protein in T and B lymphocytes, and detection of related proteins in files and yeast. Biochem Biophys Res Commun. 1993 Feb 26; 191(1):201-6. Spencer RH, Chandy KG, Gutman GA. PMID: 8447822.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    89. Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol Biol Evol. 1993 Jan; 10(1):221-42. Strong M, Chandy KG, Gutman GA. PMID: 7680747.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    90. The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells. J Biol Chem. 1992 Oct 15; 267(29):20971-9. Grissmer S, Ghanshani S, Dethlefs B, McPherson JD, Wasmuth JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 1400413.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    91. Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb; 12(2):190-6. Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, Chandy KG. PMID: 1740329.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    92. Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9411-5. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG. PMID: 2251283.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    93. CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels. J Immunol. 1990 Oct 01; 145(7):2105-9. Grissmer S, Hanson DC, Natoli EJ, Cahalan MD, Chandy KG. PMID: 1975826.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    94. Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells. Eur J Immunol. 1990 Apr; 20(4):747-51. Chandy KG, Cahalan MD, Grissmer S. PMID: 1971790.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    95. A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23; 247(4945):973-5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA. PMID: 2305265.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    96. Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases? J Immunol. 1988 Aug 15; 141(4):1137-42. Grissmer S, Cahalan MD, Chandy KG. PMID: 2456342.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    97. Two types of potassium channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):379-404. Decoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2435844.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    98. Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):405-20. Decoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2435845.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    99. Ion channels in T lymphocytes. Adv Exp Med Biol. 1987; 213:85-101. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S, Lewis RS, Sutro JB. PMID: 2442978.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    100. Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation. Science. 1986 Sep 12; 233(4769):1197-200. Chandy KG, DeCoursey TE, Fischbach M, Talal N, Cahalan MD, Gupta S. PMID: 2426784.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    101. Voltage-dependent ion channels in T-lymphocytes. J Neuroimmunol. 1985 Nov; 10(1):71-95. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2414315.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    102. Electroimmunology: the physiologic role of ion channels in the immune system. J Immunol. 1985 Aug; 135(2 Suppl):787s-791s. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2409167.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    103. Ion channels in lymphocytes. J Clin Immunol. 1985 Jan; 5(1):1-6. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2579969.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    104. A voltage-gated potassium channel in human T lymphocytes. J Physiol. 1985 Jan; 358:197-237. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S. PMID: 2580081.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    105. Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med. 1984 Aug 01; 160(2):369-85. Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S. PMID: 6088661.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    106. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984 Feb 2-8; 307(5950):465-8. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 6320007.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansCells