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K George Chandy

Title(s)Professor Emeritus, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5865
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1. Proc Natl Acad Sci U S A. 2025 May 06; 122(18):e2425494122. Ong ST, Nam YW, Nasburg JA, Ramanishka A, Ng XR, Zhuang Z, Goay SSM, Nguyen HM, Singh L, Singh V, Rivera A, Eyster ME, Xu Y, Alper SL, Wulff H, Zhang M, Chandy KG. PMID: 40294255; PMCID: PMC12067266.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel. Nat Commun. 2025 Apr 17; 16(1):3690. Nam YW, Im D, Garcia ASC, Tringides ML, Nguyen HM, Liu Y, Orfali R, Ramanishka A, Pintilie G, Su CC, Cui M, Logothetis DE, Yu EW, Wulff H, Chandy KG, Zhang M. PMID: 40246884; PMCID: PMC12006403.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. High Extracellular K+ Skews T-Cell Differentiation Towards Tumour Promoting Th2 and Treg Subsets. Eur J Immunol. 2025 Feb; 55(2):e202451440. Wong BHS, Poh ZS, Wei JTC, Amuthavalli K, Ho YS, Chen S, Mak SY, Bi X, Webster RD, Shelat VG, Chandy KG, Verma NK. PMID: 39651799; PMCID: PMC11830381.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma. Nat Commun. 2024 Mar 08; 15(1):2113. Liu M, Bertolazzi G, Sridhar S, Lee RX, Jaynes P, Mulder K, Syn N, Hoppe MM, Fan S, Peng Y, Thng J, Chua R, Batumalai Y, De Mel S, Poon L, Chan EHL, Lee J, Hue SS, Chang ST, Chuang SS, Chandy KG, Ye X, Pan-Hammarström Q, Ginhoux F, Chee YL, Ng SB, Tripodo C, Jeyasekharan AD. PMID: 38459052; PMCID: PMC10923916.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    5. Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads. Channels (Austin). 2023 12; 17(1):2253104. Chandy KG, Sanches K, Norton RS. PMID: 37695839; PMCID: PMC10496531.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics. J Chem Inf Model. 2023 05 22; 63(10):3043-3053. Sanches K, Prypoten V, Chandy KG, Chalmers DK, Norton RS. PMID: 37143234.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint. EBioMedicine. 2022 Sep; 83:104216. Verma NK, Wong BHS, Poh ZS, Udayakumar A, Verma R, Goh RKJ, Duggan SP, Shelat VG, Chandy KG, Grigoropoulos NF. PMID: 35986950; PMCID: PMC9403334.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    8. Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels. Front Pharmacol. 2022; 13:924289. Ong ST, Tyagi A, Chandy KG, Bhushan S. PMID: 35833027; PMCID: PMC9271579.
      View in: PubMed   Mentions: 7  
    9. Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response. Cancers (Basel). 2022 Feb 26; 14(5). Goggi JL, Khanapur S, Ramasamy B, Hartimath SV, Rong TJ, Cheng P, Tan YX, Yeo XY, Jung S, Goay SSM, Ong ST, Hwang YY, Chandy KG, Robins EG. PMID: 35267526; PMCID: PMC8909107.
      View in: PubMed   Mentions: 4  
    10. Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Tyagi A, Ahmed T, Jian S, Bajaj S, Ong ST, Goay SSM, Zhao Y, Vorobyov I, Tian C, Chandy KG, Bhushan S. PMID: 35091471; PMCID: PMC8812516.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    11. Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis. Front Pharmacol. 2021; 12:714841. Markakis I, Charitakis I, Beeton C, Galani M, Repousi E, Aggeloglou S, Sfikakis PP, Pennington MW, Chandy KG, Poulopoulou C. PMID: 34630091; PMCID: PMC8495199.
      View in: PubMed   Mentions: 2  
    12. Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3. Cell Discov. 2021 Jun 01; 7(1):39. Liu S, Zhao Y, Dong H, Xiao L, Zhang Y, Yang Y, Ong ST, Chandy KG, Zhang L, Tian C. PMID: 34059645; PMCID: PMC8167131.
      View in: PubMed   Mentions: 15  
    13. CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice. Front Immunol. 2020; 11:580968. Her Z, Tan JHL, Lim YS, Tan SY, Chan XY, Tan WWS, Liu M, Yong KSM, Lai F, Ceccarello E, Zheng Z, Fan Y, Chang KTE, Sun L, Chang SC, Chin CL, Lee GH, Dan YY, Chan YS, Lim SG, Chan JKY, Chandy KG, Chen Q. PMID: 33013934; PMCID: PMC7516019.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    14. Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):720-736. Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, Lescar J, Patil R, Charman SA, Robins EG, Goggi JL, Tan PW, Sadasivam P, Ramasamy B, Hartimath SV, Dhawan V, Bednenko J, Colussi P, Wulff H, Pennington MW, Kuyucak S, Norton RS, Beeton C, Chandy KG. PMID: 32832873; PMCID: PMC7432667.
      View in: PubMed   Mentions: 12  
    15. Contributions of natural products to ion channel pharmacology. Nat Prod Rep. 2020 05 01; 37(5):703-716. Bajaj S, Ong ST, Chandy KG. PMID: 32065187.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    16. Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment. Bioelectricity. 2019 Sep 01; 1(3):169-179. Ong ST, Ng AS, Ng XR, Zhuang Z, Wong BHS, Prasannan P, Kok YJ, Bi X, Shim H, Wulff H, Chandy KG, Verma NK. PMID: 34471819; PMCID: PMC8370284.
      View in: PubMed   Mentions: 26  
    17. Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 05; 18(5):339-357. Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. PMID: 30728472; PMCID: PMC6499689.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    18. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells. Br J Cancer. 2018 01; 118(2):200-212. Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A. PMID: 29161243; PMCID: PMC5785745.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    19. A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva. J Vis Exp. 2017 07 05; (125). Bose T, Hou A, Lee R, Tong L, Chandy KG. PMID: 28715398; PMCID: PMC5608542.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Venom-derived peptide inhibitors of voltage-gated potassium channels. Neuropharmacology. 2017 Dec; 127:124-138. Norton RS, Chandy KG. PMID: 28689025.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    21. A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue. J Vis Exp. 2017 06 07; (124). Hou A, Bose T, Chandy KG, Tong L. PMID: 28654074; PMCID: PMC5608287.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease. Curr Opin Chem Biol. 2017 Jun; 38:97-107. Chandy KG, Norton RS. PMID: 28412597.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    23. Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease. Sci Rep. 2017 03 27; 7:45312. Bose T, Lee R, Hou A, Tong L, Chandy KG. PMID: 28345628; PMCID: PMC5366884.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    24. International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacol Rev. 2017 01; 69(1):1-11. Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. PMID: 28267675; PMCID: PMC11060434.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    25. Immunology: Channelling potassium to fight cancer. Nature. 2016 09 22; 537(7621):497-499. Chandy KG, Norton RS. PMID: 27626384.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    26. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Sep; 28(9):3952-64. Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. PMID: 24891519; PMCID: PMC4139903.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    27. Blockade of Kv1.3 channels ameliorates radiation-induced brain injury. Neuro Oncol. 2014 Apr; 16(4):528-39. Peng Y, Lu K, Li Z, Zhao Y, Wang Y, Hu B, Xu P, Shi X, Zhou B, Pennington M, Chandy KG, Tang Y. PMID: 24305723; PMCID: PMC3956348.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci. 2013 Oct 09; 33(41):16310-22. Lioudyno MI, Birch AM, Tanaka BS, Sokolov Y, Goldin AL, Chandy KG, Hall JE, Alkire MT. PMID: 24107962; PMCID: PMC3792466.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    29. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2239-48. Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. PMID: 23729813; PMCID: PMC3683782.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    30. Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease. J Biol Chem. 2013 Mar 01; 288(9):6451-64. Nguyen HM, Galea CA, Schmunk G, Smith BJ, Edwards RA, Norton RS, Chandy KG. PMID: 23300077; PMCID: PMC3585079.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    31. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82. Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. PMID: 23090990; PMCID: PMC3494885.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    32. Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. J Pharmacol Exp Ther. 2012 Sep; 342(3):642-53. Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, Knapp B, Kentala D, Hansen Z, Pennington MW, Beeton C, Chandy KG, Iadonato SP. PMID: 22637724; PMCID: PMC3422530.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    33. Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. J Immunol. 2012 Jun 15; 188(12):5877-86. Gocke AR, Lebson LA, Grishkan IV, Hu L, Nguyen HM, Whartenby KA, Chandy KG, Calabresi PA. PMID: 22581856; PMCID: PMC3370138.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    34. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med. 2012 Jul; 4(7):577-93. Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabò I. PMID: 22496117; PMCID: PMC3407946.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    35. Therapeutic potential of peptide toxins that target ion channels. Inflamm Allergy Drug Targets. 2011 Oct; 10(5):322-42. Beraud E, Chandy KG. PMID: 21745182.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    36. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases. Toxicon. 2012 Mar 15; 59(4):529-46. Chi V, Pennington MW, Norton RS, Tarcha EJ, Londono LM, Sims-Fahey B, Upadhyay SK, Lakey JT, Iadonato S, Wulff H, Beeton C, Chandy KG. PMID: 21867724; PMCID: PMC3397671.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    37. 18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies. J Nucl Med. 2011 Jul; 52(7):1125-32. Garcia A, Mirbolooki MR, Constantinescu C, Pan ML, Sevrioukov E, Milne N, Wang PH, Lakey J, Chandy KG, Mukherjee J. PMID: 21680697.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    38. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nat Commun. 2011; 2:334. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M. PMID: 21629267; PMCID: PMC3133923.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    39. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010 Mar 19; 285(12):9124-36. Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. PMID: 19965868; PMCID: PMC2838332.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    40. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009 Sep; 231(1):59-87. Cahalan MD, Chandy KG. PMID: 19754890; PMCID: PMC3133616.
      View in: PubMed   Mentions: 338     Fields:    Translation:HumansAnimalsCells
    41. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets. 2009 Aug; 13(8):909-24. Rangaraju S, Chi V, Pennington MW, Chandy KG. PMID: 19538097.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    42. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr; 75(4):762-73. Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. PMID: 19122005; PMCID: PMC2684922.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    43. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. PMID: 18835197; PMCID: PMC2732399.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    44. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest. 2008 Sep; 118(9):3025-37. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. PMID: 18688283; PMCID: PMC2496961.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    45. Imaging effector memory T cells in the ear after induction of adoptive DTH. J Vis Exp. 2008 Aug 14; (18). Matheu MP, Beeton C, Parker I, Chandy KG, D Cahalan M. PMID: 19066497; PMCID: PMC3253563.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    46. Isolation of mononuclear cells from the central nervous system of rats with EAE. J Vis Exp. 2007; (10):527. Beeton C, Chandy KG. PMID: 18989401; PMCID: PMC2557079.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    47. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11; 283(2):988-97. Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS. PMID: 17984097.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    48. Preparing T cell growth factor from rat splenocytes. J Vis Exp. 2007; (10):402. Beeton C, Chandy KG. PMID: 18989399; PMCID: PMC2557076.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    49. Induction and monitoring of adoptive delayed-type hypersensitivity in rats. J Vis Exp. 2007 Oct 01; (8). Beeton C, Chandy KG. PMID: 19252470; PMCID: PMC2956222.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    50. Immunohistochemistry: paraffin sections using the Vectastain ABC kit from vector labs. J Vis Exp. 2007; (8):308. Chi V, Chandy KG. PMID: 18989415; PMCID: PMC2562491.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    51. Enrichment of NK cells from human blood with the RosetteSep kit from StemCell technologies. J Vis Exp. 2007; (8):326. Beeton C, Chandy KG. PMID: 18989426; PMCID: PMC2562500.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    52. Drawing blood from rats through the saphenous vein and by cardiac puncture. J Vis Exp. 2007; (7):266. Beeton C, Garcia A, Chandy KG. PMID: 18989437; PMCID: PMC2565848.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    53. Induction and monitoring of active delayed type hypersensitivity (DTH) in rats. J Vis Exp. 2007; (6):237. Beeton C, Chandy KG. PMID: 18997885; PMCID: PMC2557114.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    54. Induction and clinical scoring of chronic-relapsing experimental autoimmune encephalomyelitis. J Vis Exp. 2007; (5):224. Beeton C, Garcia A, Chandy KG. PMID: 18979022; PMCID: PMC2557091.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    55. Mouse adrenal chromaffin cell isolation. J Vis Exp. 2007 Jan 05; (2):129. Kolski-Andreaco A, Cai H, Currle DS, Chandy KG, Chow RH. PMID: 18830430; PMCID: PMC2532942.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    56. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564; PMCID: PMC1859943.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimalsCells
    57. Potassium channels, memory T cells, and multiple sclerosis. Neuroscientist. 2005 Dec; 11(6):550-62. Beeton C, Chandy KG. PMID: 16282596.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    58. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):463-72. Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. PMID: 16382103.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimals
    59. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev. 2005 Dec; 57(4):473-508. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X. PMID: 16382104.
      View in: PubMed   Mentions: 420     Fields:    Translation:HumansAnimals
    60. The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11094-9. Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA. PMID: 16043714; PMCID: PMC1182417.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    61. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Mol Pharmacol. 2005 Apr; 67(4):1369-81. Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. PMID: 15665253; PMCID: PMC4275123.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    62. K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004 Jul 15; 173(2):776-86. Wulff H, Knaus HG, Pennington M, Chandy KG. PMID: 15240664.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    63. Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun; 65(6):1364-74. Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG. PMID: 15155830.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    64. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495; PMCID: PMC2749963.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansCells
    65. SKCa channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons. J Neurosci. 2004 Apr 07; 24(14):3537-42. Villalobos C, Shakkottai VG, Chandy KG, Michelhaugh SK, Andrade R. PMID: 15071101; PMCID: PMC6729743.
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    66. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. J Clin Invest. 2004 Feb; 113(4):582-90. Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. PMID: 14966567; PMCID: PMC338266.
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    67. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 2003 Dec; 55(4):583-6. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology. PMID: 14657415.
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    69. Potassium channels as therapeutic targets for autoimmune disorders. Curr Opin Drug Discov Devel. 2003 Sep; 6(5):640-7. Wulff H, Beeton C, Chandy KG. PMID: 14579513.
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    70. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 02; 108(9):1119-25. Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J. PMID: 12939222.
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    71. The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. J Clin Invest. 2003 Jun; 111(11):1703-13. Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG. PMID: 12782673; PMCID: PMC156104.
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    72. Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. Mol Psychiatry. 2003 May; 8(5):524-35, 460. Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. PMID: 12808432.
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    73. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
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    74. Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3. Biochemistry. 2002 Oct 08; 41(40):11963-71. Lanigan MD, Kalman K, Lefievre Y, Pennington MW, Chandy KG, Norton RS. PMID: 12356296.
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    75. Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan; 10(1):36-43. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. PMID: 11896454.
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    76. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
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    77. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451; PMCID: PMC61146.
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    78. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001 Sep; 39(9):1269-76. Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. PMID: 11384714.
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    79. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16; 276(46):43145-51. Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. PMID: 11527975.
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    80. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001 Jul; 21(4):235-52. Cahalan MD, Wulff H, Chandy KG. PMID: 11506193.
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    81. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5. Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
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    82. Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. J Biol Chem. 2001 Jul 27; 276(30):27753-6. Miller MJ, Rauer H, Tomita H, Rauer H, Gargus JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 11395478.
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    83. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13; 276(15):12249-56. Fanger CM, Rauer H, Neben AL, Miller MJ, Rauer H, Wulff H, Rosa JC, Ganellin CR, Chandy KG, Cahalan MD. PMID: 11278890.
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    84. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem. 2000 Nov 24; 275(47):37137-49. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. PMID: 10961988.
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    85. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 07 05; 97(14):8151-6. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437; PMCID: PMC16685.
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    86. Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels. J Biol Chem. 2000 Jan 14; 275(2):1201-8. Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG. PMID: 10625664.
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    87. Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin. Biochemistry. 1999 Nov 02; 38(44):14549-58. Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS. PMID: 10545177.
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    88. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends Pharmacol Sci. 1999 Nov; 20(11):444-7. Tytgat J, Chandy KG, Garcia ML, Gutman GA, Martin-Eauclaire MF, van der Walt JJ, Possani LD. PMID: 10542442.
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    89. Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21. Am J Med Genet. 1999 Aug 20; 88(4):348-51. Antonarakis SE, Blouin JL, Lasseter VK, Gehrig C, Radhakrishna U, Nestadt G, Housman DE, Kazazian HH, Kalman K, Gutman G, Fantino E, Chandy KG, Gargus JJ, Pulver AE. PMID: 10402501.
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    90. Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30; 274(31):21885-92. Rauer H, Pennington M, Cahalan M, Chandy KG. PMID: 10419508.
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    91. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Mol Psychiatry. 1999 May; 4(3):254-60. Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy KG, Gargus JJ, Gutman GA, Navon R. PMID: 10395215.
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    92. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr; 126(8):1707-16. Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG. PMID: 10372812; PMCID: PMC1565958.
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    93. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem. 1999 Feb 26; 274(9):5746-54. Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J. PMID: 10026195.
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    94. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. 1998 Dec 04; 273(49):32697-707. Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. PMID: 9830012.
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    95. Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia. Biochem Biophys Res Commun. 1998 Oct 20; 251(2):662-5. Li T, Hu X, Chandy KG, Fantino E, Kalman K, Gutman G, Gargus JJ, Freeman B, Murray RM, Dawson E, Liu X, Bruinvels AT, Sham PC, Collier DA. PMID: 9792831.
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    96. Two-dimensional crystallization and projection structure of KcsA potassium channel. J Mol Biol. 1998 Sep 18; 282(2):211-6. Li HL, Sui HX, Ghanshani S, Lee S, Walian PJ, Wu CL, Chandy KG, Jap BK. PMID: 9735281.
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    97. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J Biol Chem. 1998 Aug 07; 273(32):20109-13. Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA. PMID: 9685353.
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    98. Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. Genomics. 1998 Jul 01; 51(1):160-1. Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG. PMID: 9693050.
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    99. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Mol Psychiatry. 1998 May; 3(3):266-9. Bowen T, Guy CA, Craddock N, Cardno AG, Williams NM, Spurlock G, Murphy KC, Jones LA, Gray M, Sanders RD, McCarthy G, Chandy KG, Fantino E, Kalman K, Gutman GA, Gargus JJ, Williams J, McGuffin P, Owen MJ, O'Donovan MC. PMID: 9672903.
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    100. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem. 1998 Mar 06; 273(10):5851-7. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. PMID: 9488722.
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    101. Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol. 1998 Jan 15; 506 ( Pt 2):291-301. Jäger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S. PMID: 9490854; PMCID: PMC2230732.
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    102. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? Mol Psychiatry. 1998 Jan; 3(1):32-7. Chandy KG, Fantino E, Wittekindt O, Kalman K, Tong LL, Ho TH, Gutman GA, Crocq MA, Ganguli R, Nimgaonkar V, Morris-Rosendahl DJ, Gargus JJ. PMID: 9491810.
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    103. Ion channels in the immune system as targets for immunosuppression. Curr Opin Biotechnol. 1997 Dec; 8(6):749-56. Cahalan MD, Chandy KG. PMID: 9425667.
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    104. Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J Biol Chem. 1997 Oct 24; 272(43):26899-904. Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH. PMID: 9341123.
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    105. Purification, visualization, and biophysical characterization of Kv1.3 tetramers. J Biol Chem. 1997 Jan 24; 272(4):2389-95. Spencer RH, Sokolov Y, Li H, Takenaka B, Milici AJ, Aiyar J, Nguyen A, Park H, Jap BK, Hall JE, Gutman GA, Chandy KG. PMID: 8999950.
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    106. The signature sequence of voltage-gated potassium channels projects into the external vestibule. J Biol Chem. 1996 Dec 06; 271(49):31013-6. Aiyar J, Rizzi JP, Gutman GA, Chandy KG. PMID: 8940091.
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    107. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec; 50(6):1672-9. Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG. PMID: 8967992.
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    108. Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene. J Biol Chem. 1996 Jun 28; 271(26):15629-34. Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG. PMID: 8663090.
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    109. The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway. Biophys J. 1994 Dec; 67(6):2261-4. Aiyar J, Nguyen AN, Chandy KG, Grissmer S. PMID: 7696467; PMCID: PMC1225609.
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    110. Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun; 45(6):1227-34. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. PMID: 7517498.
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    111. Nomenclature for mammalian potassium channel genes. Trends Pharmacol Sci. 1993 Dec; 14(12):434. Chandy KG, Gutman GA. PMID: 8122319.
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    112. Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1571-8. Aiyar J, Grissmer S, Chandy KG. PMID: 7506490.
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    113. Immunological Identification of the Shaker-Related Kv1.3 Potassium Channel Protein in T and B Lymphocytes, and Detection of Related Proteins in Flies and Yeast Biochem Biophys Res Commun. 1993 02 26; 191(1):201-6. Spencer RH, Chandy KG, Gutman GA. PMID: 8447822.
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    114. Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol Biol Evol. 1993 Jan; 10(1):221-42. Strong M, Chandy KG, Gutman GA. PMID: 7680747.
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    115. The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells. J Biol Chem. 1992 Oct 15; 267(29):20971-9. Grissmer S, Ghanshani S, Dethlefs B, McPherson JD, Wasmuth JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 1400413.
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    116. Induction of thymus-reestablishing lymphoid tumors by a murine leukemia virus carrying the avian v-myc oncogene. Thymus. 1992 Aug; 20(1):47-61. Spencer RH, Brightman BK, Trepp DJ, Fan H, Chandy KG. PMID: 1325692.
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    117. Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb; 12(2):190-6. Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, Chandy KG. PMID: 1740329.
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    118. Simplified gene nomenclature. Nature. 1991 Jul 04; 352(6330):26. Chandy KG. PMID: 2062374.
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    119. Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9411-5. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG. PMID: 2251283; PMCID: PMC55175.
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    120. CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels. J Immunol. 1990 Oct 01; 145(7):2105-9. Grissmer S, Hanson DC, Natoli EJ, Cahalan MD, Chandy KG. PMID: 1975826.
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    121. Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells. Eur J Immunol. 1990 Apr; 20(4):747-51. Chandy KG, Cahalan MD, Grissmer S. PMID: 1971790.
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    122. A family of three mouse potassium channel genes with intronless coding regions. Science. 1990 Feb 23; 247(4945):973-5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA. PMID: 2305265.
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    126. Interferon responsiveness of natural killer cells in type I human diabetes. Diabetes Res. 1988 Jan; 7(1):49-52. Negishi K, Gupta S, Chandy KG, Waldeck N, Kershnar A, Buckingham B, Charles MA. PMID: 3402165.
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    127. Interleukin-2-like activity in injured rat brain. Neurochem Res. 1987 Aug; 12(8):723-7. Nieto-Sampedro M, Chandy KG. PMID: 3114659.
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    128. Characterization of a preleukemic state induced by Moloney murine leukemia virus: evidence for two infection events during leukemogenesis. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4875-9. Davis BR, Brightman BK, Chandy KG, Fan H. PMID: 3474632; PMCID: PMC305208.
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    133. Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation. Science. 1986 Sep 12; 233(4769):1197-200. Chandy KG, DeCoursey TE, Fischbach M, Talal N, Cahalan MD, Gupta S. PMID: 2426784.
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    134. Voltage-dependent ion channels in T-lymphocytes. J Neuroimmunol. 1985 Nov; 10(1):71-95. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2414315.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    135. Electroimmunology: the physiologic role of ion channels in the immune system. J Immunol. 1985 Aug; 135(2 Suppl):787s-791s. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2409167.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    136. Acute effects of dialysis on T lymphocytes in patients with end-stage renal disease. J Clin Lab Immunol. 1985 Jul; 17(3):119-24. Chandy KG, Pahl M, Vaziri ND, Gupta S. PMID: 3930749.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    137. A voltage-gated potassium channel in human T lymphocytes. J Physiol. 1985 Jan; 358:197-237. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S. PMID: 2580081; PMCID: PMC1193339.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    138. Ion channels in lymphocytes. J Clin Immunol. 1985 Jan; 5(1):1-6. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2579969.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    139. Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus. J Clin Immunol. 1984 Nov; 4(6):424-8. Chandy KG, Charles AM, Kershnar A, Buckingham B, Waldeck N, Gupta S. PMID: 6239872.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    140. Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med. 1984 Aug 01; 160(2):369-85. Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S. PMID: 6088661; PMCID: PMC2187449.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    141. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984 Feb 2-8; 307(5950):465-8. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 6320007.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansCells
    142. Deficiency of monoclonal antibody (Leu 7) defined NK cells in newly diagnosed insulin-dependent diabetes mellitus. Immunol Lett. 1984; 8(2):89-91. Chandy KG, Charles MA, Buckingham B, Waldeck N, Kershnar A, Gupta S. PMID: 6746020.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    143. Serum secretory component: a potential marker of biliary obstruction. Clin Chim Acta. 1983 Sep 15; 133(1):65-73. Farris MA, Chandy KG, Ashdown K, Elias E, Burnett D. PMID: 6627677.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    144. Dual role of the liver in regulating circulating polymeric IgA in man: studies on patients with liver disease. Clin Exp Immunol. 1983 Apr; 52(1):207-18. Chandy KG, Hübscher SG, Elias E, Berg J, Khan M, Burnett D. PMID: 6345033; PMCID: PMC1535560.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    145. Evidence for a single-chain structure of native human ceruloplasmin using sodium dodecyl sulfate-polyacrylamide-crossed immunoelectrophoresis. Anal Biochem. 1983 Feb 01; 128(2):317-22. Burnett D, Chandy KG. PMID: 6846808.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    146. Viral antibody titres in non-systemic glomerular disease. Indian J Med Res. 1982 Oct; 76:504-7. Date A, Shastry JC, Chandy KG, John TJ. PMID: 6295929.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    147. Relationship between serum viscosity and intravascular IgA polymer concentration in IgA myeloma. Clin Exp Immunol. 1981 Dec; 46(3):653-61. Chandy KG, Stockley RA, Leonard RC, Crockson RA, Burnett D, MacLennan IC. PMID: 7337982; PMCID: PMC1536291.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    148. Abnormalities of the immune system in patients with chyluria. Br J Urol. 1981 Aug; 53(4):384-6. Date A, John TJ, Chandy KG, Rajagopalan MS, Vaska PH, Pandey AP, Shastry JC. PMID: 7260554.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    149. The potential toxicity of excessive polyunsaturated fats (an experimental study). J Assoc Physicians India. 1981 Feb; 29(2):95-9. Chandy KG, Uthaman B, Balasubramaniam AS, Cherian G. PMID: 7263607.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    150. The estimation of Stokes radius for secretory immunoglobulin A, using thin-layer chromatography followed by crossed immunoelectrophoresis. Hoppe Seylers Z Physiol Chem. 1980 Dec; 361(12):1855-7. Chandy KG, Stockley RA, Burnett D. PMID: 7461611.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    151. Coxsackieviruses and chronic valvular heart disease. Am Heart J. 1980 Oct; 100(4):578-80. Chandy KG, John TJ, Cherian G. PMID: 7415944.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    152. Evidence for natural infection with group B in coxsackieviruses in bonnet monkeys. J Med Primatol. 1980; 9(5):323-4. Chandy KG, Mukundan P, John TJ. PMID: 6255160.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    153. Coxsackie B antibodies in "rheumatic" valvular heart-disease. Lancet. 1979 Feb 17; 1(8112):381. Chandy KG, John TJ, Mukundan P, Cherian G. PMID: 85028.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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