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Nigrostriatal tau pathology in parkinsonism and Parkinson's disease. Brain. 2024 02 01; 147(2):444-457.
Chu Y, Hirst WD, Federoff HJ, Harms AS, Stoessl AJ, Kordower JH. PMID: 38006313; PMCID: PMC10834249.
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PubMed Mentions:
6 Fields:
Translation:
Humans
-
Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative. J Parkinsons Dis. 2024; 14(4):657-666.
Wyse RK, Isaacs T, Barker RA, Cookson MR, Dawson TM, Devos D, Dexter DT, Duffen J, Federoff H, Fiske B, Foltynie T, Fox S, Greenamyre JT, Kieburtz K, Kordower JH, Krainc D, Matthews H, Moore DJ, Mursaleen L, Schwarzschild MA, Stott SRW, Sulzer D, Svenningsson P, Tanner CM, Carroll C, Simon DK, Brundin P. PMID: 38578902; PMCID: PMC11191436.
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PubMed Mentions: Fields:
Translation:
Humans
-
Autologous vs heterologous cell replacement strategies for Parkinson disease and other neurologic diseases. Handb Clin Neurol. 2024; 205:41-56.
Emborg ME, Gambardella JC, Zhang A, Federoff HJ. PMID: 39341662.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Preface. Handb Clin Neurol. 2024; 205:xi.
Federoff HJ, Barker RA. PMID: 39341666.
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PubMed Mentions: Fields:
-
E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury. Lancet Reg Health Am. 2022 Oct; 14:100340.
de Freitas PHM, Monteiro RC, Bertani R, Perret CM, Rodrigues PC, Vicentini J, de Morais TMG, Rozental SFA, Galvão GF, de Mattos F, Vasconcelos FA, Dorio IS, Hayashi CY, Dos Santos JRL, Werneck GL, Tocquer CTF, Capitão C, da Cruz LCH, Tulviste J, Fiorani M, da Silva MM, Paiva WS, Podell K, Federoff HJ, Patel DH, Lado F, Goldberg E, Llinás R, Bennett MVL, Rozental R. PMID: 36777390; PMCID: PMC9903712.
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PubMed Mentions:
-
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease. Geroscience. 2022 06; 44(3):1525-1550.
Macciardi F, Giulia Bacalini M, Miramontes R, Boattini A, Taccioli C, Modenini G, Malhas R, Anderlucci L, Gusev Y, Gross TJ, Padilla RM, Fiandaca MS, Head E, Guffanti G, Federoff HJ, Mapstone M. PMID: 35585302; PMCID: PMC9213607.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson's disease. NPJ Regen Med. 2022 Apr 21; 7(1):24.
Hiller BM, Marmion DJ, Thompson CA, Elliott NA, Federoff H, Brundin P, Mattis VB, McMahon CW, Kordower JH. PMID: 35449132; PMCID: PMC9023503.
View in:
PubMed Mentions:
24
-
TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC. Cancers (Basel). 2021 Dec 09; 13(24).
Rajagopal MU, Bansal S, Kaur P, Jain SK, Altadil T, Hinzman CP, Li Y, Moulton J, Singh B, Bansal S, Chauthe SK, Singh R, Banerjee PP, Mapstone M, Fiandaca MS, Federoff HJ, Unger K, Smith JP, Cheema AK. PMID: 34944824; PMCID: PMC8699757.
View in:
PubMed Mentions:
8
-
Seeking progress in disease modification in Parkinson disease. Parkinsonism Relat Disord. 2021 09; 90:134-141.
Lungu C, Cedarbaum JM, Dawson TM, Dorsey ER, Faraco C, Federoff HJ, Fiske B, Fox R, Goldfine AM, Kieburtz K, Macklin EA, Matthews H, Rafaloff G, Saunders-Pullman R, Schor NF, Schwarzschild MA, Sieber BA, Simuni T, Surmeier DJ, Tamiz A, Werner MH, Wright CB, Wyse R. PMID: 34561166.
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PubMed Mentions:
5 Fields:
Translation:
Humans
-
Differential responses of AMD mitochondrial DNA haplogroups to PU-91, a mitochondria-targeting drug. Mitochondrion. 2021 09; 60:189-200.
Bao A, Nashine S, Atilano S, Chwa M, Federoff H, Kenney MC. PMID: 34400356.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Plasma Sphingomyelins in Late-Onset Alzheimer's Disease. J Alzheimers Dis. 2021; 83(3):1161-1171.
Fote G, Wu J, Mapstone M, Macciardi F, Fiandaca MS, Federoff HJ. PMID: 34397408; PMCID: PMC9788856.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Repairing the Parkinson Brain. J Parkinsons Dis. 2021; 11(s2):S123-S125.
Björklund A, Bloem BR, Brundin P, Federoff H. PMID: 34569978.
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PubMed Mentions: Fields:
Translation:
Humans
-
Author Correction: Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep. 2020 Feb 07; 10(1):2484.
Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW. PMID: 32034207; PMCID: PMC7005777.
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PubMed Mentions: Fields:
-
GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop. J Parkinsons Dis. 2020; 10(3):875-891.
Barker RA, Björklund A, Gash DM, Whone A, Van Laar A, Kordower JH, Bankiewicz K, Kieburtz K, Saarma M, Booms S, Huttunen HJ, Kells AP, Fiandaca MS, Stoessl AJ, Eidelberg D, Federoff H, Voutilainen MH, Dexter DT, Eberling J, Brundin P, Isaacs L, Mursaleen L, Bresolin E, Carroll C, Coles A, Fiske B, Matthews H, Lungu C, Wyse RK, Stott S, Lang AE. PMID: 32508331; PMCID: PMC7458523.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
-
A Community-Based Study Identifying Metabolic Biomarkers of Mild Cognitive Impairment and Alzheimer's Disease Using Artificial Intelligence and Machine Learning. J Alzheimers Dis. 2020; 78(4):1381-1392.
Yilmaz A, Ustun I, Ugur Z, Akyol S, Hu WT, Fiandaca MS, Mapstone M, Federoff H, Maddens M, Graham SF. PMID: 33164929.
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PubMed Mentions:
14 Fields:
Translation:
Humans
-
Effect of early-stage Alzheimer's disease on household financial outcomes. Health Econ. 2020 01; 29(1):18-29.
Gresenz CR, Mitchell JM, Marrone J, Federoff HJ. PMID: 31650668.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics. Aging (Albany NY). 2019 09 02; 11(17):6691-6713.
Nashine S, Subramaniam SR, Chwa M, Nesburn A, Kuppermann BD, Federoff H, Kenney MC. PMID: 31477635; PMCID: PMC6756897.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease. Mov Disord. 2019 07; 34(7):1073-1078.
Heiss JD, Lungu C, Hammoud DA, Herscovitch P, Ehrlich DJ, Argersinger DP, Sinharay S, Scott G, Wu T, Federoff HJ, Zaghloul KA, Hallett M, Lonser RR, Bankiewicz KS. PMID: 31145831; PMCID: PMC6642028.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
-
Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media. Int J Mol Sci. 2018 Nov 09; 19(11).
Lehrich BM, Liang Y, Khosravi P, Federoff HJ, Fiandaca MS. PMID: 30423996; PMCID: PMC6275013.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Protect NIH's DNA advisory committee. Science. 2018 10 26; 362(6413):409-410.
Adelman ZN, Albritton LM, Boris-Lawrie K, Buchmeier MJ, Cannon P, Cho M, DiGiusto D, Donahue JK, Federoff HJ, Hammarskjold ML, Hardison AD, Hearing P, Lee B, Lee DA, Porteus MH, Ross LF, Ross SR, Wooley DP, Zoloth L. PMID: 30361364.
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PubMed Mentions: Fields:
Translation:
Humans
-
Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury. Metabolites. 2018 Sep 07; 8(3).
Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. PMID: 30205491; PMCID: PMC6161135.
View in:
PubMed Mentions:
11
-
Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep. 2018 08 22; 8(1):12558.
Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW. PMID: 30135469; PMCID: PMC6105620.
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PubMed Mentions:
14 Fields:
Translation:
Humans
-
Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018; 13(4):e0195318.
Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ. PMID: 29677216; PMCID: PMC5909890.
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PubMed Mentions:
21 Fields:
Translation:
Humans
-
Precision pharmacology for Alzheimer's disease. Pharmacol Res. 2018 04; 130:331-365.
Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S, Alzheimer Precision Medicine Initiative (APMI). PMID: 29458203; PMCID: PMC8505114.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
-
Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development. Curr Top Med Chem. 2018; 18(11):883-895.
Gross T, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS. PMID: 29992885.
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PubMed Mentions:
7 Fields:
Translation:
Humans
-
Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017 Dec 19; 11(1):142.
Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki ES, Malik S, Macciardi F, Federoff HJ. PMID: 29258513; PMCID: PMC5738174.
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PubMed Mentions:
13 Fields:
Translation:
Humans
-
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget. 2017 Sep 15; 8(40):68899-68915.
Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, Cheema AK. PMID: 28978166; PMCID: PMC5620306.
View in:
PubMed Mentions:
27 Fields:
-
Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype. Int J Geriatr Psychiatry. 2018 02; 33(2):332-339.
Chapman BP, Benedict RHB, Lin F, Roy S, Porteinsson A, Szigeti K, Federoff H, Mapstone M. PMID: 28612377.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Front Aging Neurosci. 2017; 9:176.
Subramaniam SR, Federoff HJ. PMID: 28642697; PMCID: PMC5463358.
View in:
PubMed Mentions:
143
-
Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models. Mol Ther. 2017 10 04; 25(10):2231-2235.
Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff HJ. PMID: 28522034; PMCID: PMC5628770.
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PubMed Mentions:
29 Fields:
Translation:
Humans
-
Personality and Performance in Specific Neurocognitive Domains Among Older Persons. Am J Geriatr Psychiatry. 2017 Aug; 25(8):900-908.
Chapman BP, Benedict RH, Lin F, Roy S, Federoff HJ, Mapstone M. PMID: 28456386; PMCID: PMC5647872.
View in:
PubMed Mentions:
22 Fields:
Translation:
Humans
-
Biomarker validation: Methods and matrix matter. Alzheimers Dement. 2017 05; 13(5):608-609.
Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff HJ. PMID: 28010950.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Mol Ther. 2008 Apr; 16(4):640-646.
Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. PMID: 28178462.
View in:
PubMed Mentions:
1 Fields:
-
Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4. Mol Ther. 2008 May; 16(5):845-853.
Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. PMID: 28178487.
View in:
PubMed Mentions:
5 Fields:
-
What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 03; 51:148-155.
Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. PMID: 27939698; PMCID: PMC5985530.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
-
A genome-wide association study in multiple system atrophy. Neurology. 2016 Oct 11; 87(15):1591-1598.
Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H, European Multiple System Atrophy Study Group and the UK Multiple System Atrophy Study Group. PMID: 27629089; PMCID: PMC5067544.
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PubMed Mentions:
76 Fields:
Translation:
Humans
-
Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Front Neurol. 2015; 6:237.
Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. PMID: 26617567; PMCID: PMC4642213.
View in:
PubMed Mentions:
64
-
PGC-1α Promoter Methylation in Parkinson's Disease. PLoS One. 2015; 10(8):e0134087.
Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff HJ. PMID: 26317511; PMCID: PMC4552803.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCells
-
Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 2015 Oct; 14(10):1002-9.
Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB, Parkinson's Disease Biomarkers Program and Parkinson's Progression Marker Initiative investigators. PMID: 26271532; PMCID: PMC4575273.
View in:
PubMed Mentions:
107 Fields:
Translation:
Humans
-
Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci. 2015; 9:231.
Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff HJ, Newport EL. PMID: 25972803; PMCID: PMC4413691.
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PubMed Mentions:
24
-
Perspectives on best practices for gene therapy programs. Hum Gene Ther. 2015 Mar; 26(3):127-33.
Cheever TR, Berkley D, Braun S, Brown RH, Byrne BJ, Chamberlain JS, Cwik V, Duan D, Federoff HJ, High KA, Kaspar BK, Klinger KW, Larkindale J, Lincecum J, Mavilio F, McDonald CL, McLaughlin J, Weiss McLeod B, Mendell JR, Nuckolls G, Stedman HH, Tagle DA, Vandenberghe LH, Wang H, Wernett PJ, Wilson JM, Porter JD, Gubitz AK. PMID: 25654329; PMCID: PMC4367233.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82.
Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. PMID: 25473422; PMCID: PMC4254417.
View in:
PubMed Mentions:
87 Fields:
-
Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1.
Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. PMID: 25130657; PMCID: PMC4329112.
View in:
PubMed Mentions:
468 Fields:
Translation:
HumansCells
-
Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97.
O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. PMID: 24773122; PMCID: PMC4064731.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
-
The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S196-212.
Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. PMID: 24924671.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimals
-
Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Res Int. 2014; 2014:275178.
Su X, Federoff HJ. PMID: 24822191; PMCID: PMC4005076.
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PubMed Mentions:
46 Fields:
Translation:
Humans
-
The evolution of gene transfer, gene therapy, and the RAC: IOM recommendations to the NIH director. Mol Ther. 2014 Apr; 22(4):685-6.
Federoff HJ, Wagner JE. PMID: 24691174; PMCID: PMC3982498.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr; 20(4):415-8.
Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. PMID: 24608097; PMCID: PMC5360460.
View in:
PubMed Mentions:
471 Fields:
Translation:
Humans
-
Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics. 2013 Oct; 10(4):840-51.
Huang L, Shimoji M, Wang J, Shah S, Kamila S, Biehl ER, Lim S, Chang A, Maguire-Zeiss KA, Su X, Federoff HJ. PMID: 23963789; PMCID: PMC3805857.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. Int J Mol Sci. 2013 Sep 17; 14(9):19109-27.
Huang L, Su X, Federoff HJ. PMID: 24048248; PMCID: PMC3794823.
View in:
PubMed Mentions:
17 Fields:
Translation:
Humans
-
Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease. Expert Rev Neurother. 2013 Jun; 13(6):685-93.
MacArthur L, Ressom H, Shah S, Federoff HJ. PMID: 23739005.
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PubMed Mentions: Fields:
Translation:
Humans
-
Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding? Exp Neurol. 2014 Jun; 256:117-25.
Fiandaca MS, Federoff HJ. PMID: 23524194.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein. J Neuroimmune Pharmacol. 2013 Mar; 8(1):94-117.
Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA. PMID: 23054368; PMCID: PMC3582877.
View in:
PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
-
Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet Neurol. 2012 Jul; 11(7):643-50.
Galpern WR, Corrigan-Curay J, Lang AE, Kahn J, Tagle D, Barker RA, Freeman TB, Goetz CG, Kieburtz K, Kim SY, Piantadosi S, Comstock Rick A, Federoff HJ. PMID: 22710757.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Genomics and bioinformatics of Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a009449.
Scholz SW, Mhyre T, Ressom H, Shah S, Federoff HJ. PMID: 22762024; PMCID: PMC3385936.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 2012 Jul 10; 79(2):127-31.
Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff HJ, Traynor BJ, Singleton AB, Houlden H. PMID: 22675081; PMCID: PMC3390538.
View in:
PubMed Mentions:
21 Fields:
Translation:
Humans
-
Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel). 2012 Jun 04; 5(6):553-90.
Fiandaca MS, Bankiewicz KS, Federoff HJ. PMID: 24281662; PMCID: PMC3763661.
View in:
PubMed Mentions:
6
-
EDITORIAL: TECHNOLOGY, INNOVATION, AND HEALTH. Technol Innov. 2012 Apr 01; 13(4):261-262.
Sanberg PR, Federoff HJ. PMID: 24744821; PMCID: PMC3987958.
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PubMed Mentions:
-
TECHNOLOGY AND INVENTION. Technol Innov. 2012; 14(1):1-2.
Sanberg PR, Federoff HJ. PMID: 25254084; PMCID: PMC4171041.
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PubMed Mentions:
-
Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density. J Neurochem. 2012 Mar; 120(5):741-51.
Lim ST, Chang A, Giuliano RE, Federoff HJ. PMID: 22118475.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728.
Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 22132130; PMCID: PMC3221672.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Characterization of nectin processing mediated by presenilin-dependent γ-secretase. J Neurochem. 2011 Dec; 119(5):945-56.
Kim J, Chang A, Dudak A, Federoff HJ, Lim ST. PMID: 21910732; PMCID: PMC3217175.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. Eur J Neurosci. 2011 Oct; 34(8):1256-67.
Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. PMID: 21995852; PMCID: PMC3195885.
View in:
PubMed Mentions:
21 Translation:
HumansAnimalsCells
-
Disclosure of clinical trial results when product development is abandoned. Sci Transl Med. 2011 Sep 28; 3(102):102cm29.
Rogawski MA, Federoff HJ. PMID: 21957167.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Membrane palmitoylated proteins regulate trafficking and processing of nectins. Eur J Cell Biol. 2011 May; 90(5):365-75.
Dudak A, Kim J, Cheong B, Federoff HJ, Lim ST. PMID: 21371776; PMCID: PMC3060411.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57.
Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. PMID: 21343917; PMCID: PMC3129792.
View in:
PubMed Mentions:
64 Fields:
Translation:
AnimalsCells
-
Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy. 2011 Feb; 3(2):287-98.
Shah S, Federoff HJ. PMID: 21322764.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Technology and innovation: 2010 a year in review. Cell Transplant. 2011; 20(8):1315-9.
Sanberg PR, Vindrola-Padros C, Eve DJ, Federoff HJ. PMID: 22080749.
View in:
PubMed Mentions: Fields:
-
Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):852-7.
Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. PMID: 21187387; PMCID: PMC3021064.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
-
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 06; 2(52):52ra73.
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR, Global PD Gene Expression (GPEX) Consortium. PMID: 20926834; PMCID: PMC3129986.
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PubMed Mentions:
442 Fields:
Translation:
HumansCells
-
Georgetown University School of Medicine. Acad Med. 2010 Sep; 85(9 Suppl):S131-5.
Sistrunk SI, Kumar P, Walther J, Gwinn L, Williams J, Moore ES, Frank I, Weissinger P, Brown LW, Mitchell SR, Federoff HJ. PMID: 20736531.
View in:
PubMed Mentions: Fields:
-
A new research and development policy framework for the biomedical research enterprise. JAMA. 2010 Sep 01; 304(9):1003-4.
Federoff HJ, Rubin ER. PMID: 20810378.
View in:
PubMed Mentions:
1 Fields:
-
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med. 2010 Sep; 16(9):998-1000.
Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. PMID: 20729864; PMCID: PMC2935926.
View in:
PubMed Mentions:
184 Fields:
Translation:
HumansCells
-
Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77.
Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 20631185; PMCID: PMC2914692.
View in:
PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
-
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol Ther. 2010 Aug; 18(8):1471-81.
Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. PMID: 20551911; PMCID: PMC2927061.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
-
Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010 Jul; 32(1):10-7.
Feng LR, Federoff HJ, Vicini S, Maguire-Zeiss KA. PMID: 20550572; PMCID: PMC2900531.
View in:
PubMed Mentions:
34 Translation:
HumansAnimalsCells
-
Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. J Neural Transm (Vienna). 2010 Aug; 117(8):1019-25.
Maguire-Zeiss KA, Federoff HJ. PMID: 20549523.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
-
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem. 2010 Jul 23; 285(30):22919-26.
Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST. PMID: 20501653; PMCID: PMC2906284.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
-
An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J Neurosci Methods. 2010 Jul 15; 190(2):171-9.
Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. PMID: 20452375; PMCID: PMC2902796.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
-
The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. J Biol Chem. 2010 Jul 09; 285(28):21329-40.
Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. PMID: 20448044; PMCID: PMC2898390.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS One. 2010 Feb 02; 5(2):e9002.
Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. PMID: 20126313; PMCID: PMC2814869.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
-
Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40.
Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19671001; PMCID: PMC2861959.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Ther. 2010 Mar; 17(3):424-31.
de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. PMID: 19865178; PMCID: PMC2837128.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Death in a gene-therapy trial. N Engl J Med. 2009 Oct 29; 361(18):1811.
Zaia JA, Federoff HJ. PMID: 19864684.
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PubMed Mentions: Fields:
Translation:
Humans
-
Drug discovery dilemma and Cura quartet collaboration. Drug Discov Today. 2009 Nov; 14(21-22):1006-10.
Shah S, Federoff HJ. PMID: 19815089.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
-
Expression pattern of NuIP gene in adult mouse brain. Brain Res. 2009 Dec 11; 1302:42-53.
Luo Y, Sarabi SA, Backman C, Shan L, Hoffer B, Federoff H. PMID: 19765553.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Evolving from reductionism to holism: is there a future for systems medicine? JAMA. 2009 Sep 02; 302(9):994-6.
Federoff HJ, Gostin LO. PMID: 19724047.
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PubMed Mentions:
23 Fields:
Translation:
Humans
-
Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Mol Ther. 2009 Dec; 17(12):2031-40.
Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. PMID: 19638957; PMCID: PMC2788047.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
-
Development of vaccination approaches for the treatment of neurological diseases. J Comp Neurol. 2009 Jul 01; 515(1):4-14.
Federoff HJ. PMID: 19399901.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
-
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol. 2009 Jun 15; 185(6):1065-81.
Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA. PMID: 19528298; PMCID: PMC2711615.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
-
Immune responses to herpesviral vectors. Hum Gene Ther. 2009 May; 20(5):434-41.
Ryan DA, Federoff HJ. PMID: 19216681; PMCID: PMC2828622.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510.
Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19203243; PMCID: PMC2767387.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
-
Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Hum Gene Ther. 2009 May; 20(5):442-52.
Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. PMID: 19199821; PMCID: PMC2828628.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):511-8.
Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19254173; PMCID: PMC2725183.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimals
-
Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox Res. 2009 Oct; 16(3):238-54.
Su X, Federoff HJ, Maguire-Zeiss KA. PMID: 19526281; PMCID: PMC2877375.
View in:
PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
-
Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotox Res. 2009 Oct; 16(3):261-70.
Federoff HJ. PMID: 19526279.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35.
Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. PMID: 19095069; PMCID: PMC2730220.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82.
Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. PMID: 18974297; PMCID: PMC2626388.
View in:
PubMed Mentions:
116 Fields:
Translation:
HumansAnimalsCells
-
HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009 Apr 02; 113(14):3264-75.
Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. PMID: 18952891; PMCID: PMC3401030.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansCells
-
Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases. J Neuroimmune Pharmacol. 2009 Sep; 4(3):298-308.
Maguire-Zeiss KA, Federoff HJ. PMID: 18931916; PMCID: PMC2879638.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
A rough morphology of the adsorbed fibronectin layer favors adhesion of neuronal cells. J Biomed Mater Res A. 2008 Oct; 87(1):116-28.
Dekeyser CM, Zuyderhoff E, Giuliano RE, Federoff HJ, Dupont-Gillain ChC, Rouxhet PG. PMID: 18085643.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Identification of a novel nurr1-interacting protein. J Neurosci. 2008 Sep 10; 28(37):9277-86.
Luo Y, Xing F, Guiliano R, Federoff HJ. PMID: 18784308; PMCID: PMC6670918.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9.
Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. PMID: 18545225; PMCID: PMC2725180.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
-
Gene delivery to the nervous system. Mol Ther. 2008 Apr; 16(4):640-6.
Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. PMID: 18362921; PMCID: PMC2630580.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol Ther. 2008 May; 16(5):845-53.
Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. PMID: 18388924; PMCID: PMC2441486.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol. 2008 Mar 10; 507(2):1228-44.
Lim ST, Lim KC, Giuliano RE, Federoff HJ. PMID: 18181141.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. J Neurosci. 2008 Feb 20; 28(8):1988-93.
Vangeison G, Carr D, Federoff HJ, Rempe DA. PMID: 18287515; PMCID: PMC6671445.
View in:
PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
-
Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci. 2008 Jun; 38(2):125-37.
Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. PMID: 18439838; PMCID: PMC2652244.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. J Gene Med. 2008 Feb; 10(2):152-64.
Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. PMID: 18058952; PMCID: PMC2440655.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6.
Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. PMID: 18180775.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
-
Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother. 2008 May; 57(5):663-75.
Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. PMID: 17952436; PMCID: PMC11029851.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res. 2007 Oct 15; 67(20):10027-37.
Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. PMID: 17942937.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Exp Neurol. 2008 Jan; 209(1):101-13.
Maguire-Zeiss KA, Mhyre TR, Federoff HJ. PMID: 18035353.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 2007 Oct 16; 25(42):7410-21.
Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. PMID: 17868958; PMCID: PMC2092414.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
-
Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Mol Ther. 2007 Oct; 15(10):1848-55.
Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. PMID: 17653102; PMCID: PMC2587304.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun. 2007 Sep 28; 361(3):599-604.
Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ. PMID: 17673176.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. J Virol Methods. 2007 Oct; 145(1):37-46.
Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. PMID: 17606303; PMCID: PMC2080840.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging. 2008 Nov; 29(11):1690-701.
Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. PMID: 17537546; PMCID: PMC2621109.
View in:
PubMed Mentions:
239 Fields:
Translation:
HumansAnimalsCells
-
Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. Neurobiol Aging. 2008 Nov; 29(11):1631-43.
Mhyre TR, Loy R, Tariot PN, Profenno LA, Maguire-Zeiss KA, Zhang D, Coleman PD, Federoff HJ. PMID: 17521776; PMCID: PMC2621111.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCellsCTClinical Trials
-
Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Res. 2007 Aug 08; 1162:98-112.
Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD, Pearce DA. PMID: 17617387; PMCID: PMC4790084.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem. 2007 Jun 01; 282(22):16187-201.
Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ. PMID: 17420250.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Translational considerations for CNS gene therapy. Expert Opin Biol Ther. 2007 Mar; 7(3):305-18.
Ryan DA, Federoff HJ. PMID: 17309323.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Neuron. 2007 Feb 01; 53(3):315-7.
Federoff HJ, Mhyre TR. PMID: 17270727.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Hum Gene Ther. 2007 Feb; 18(2):93-105.
Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. PMID: 17298238.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Exp Neurol. 2007 Mar; 204(1):421-32.
Miller RM, Kiser GL, Kaysser-Kranich T, Casaceli C, Colla E, Lee MK, Palaniappan C, Federoff HJ. PMID: 17254569.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
-
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Res. 2007 Feb 23; 1134(1):33-44.
Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. PMID: 17196186; PMCID: PMC2041451.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 2007 Feb 19; 25(9):1634-46.
Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. PMID: 17145123; PMCID: PMC1851942.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiol Aging. 2008 Jan; 29(1):71-7.
Miller RM, Federoff HJ. PMID: 17101197.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. J Gene Med. 2006 Nov; 8(11):1320-8.
Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. PMID: 16989006.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
VIP is a transcriptional target of Nurr1 in dopaminergic cells. Exp Neurol. 2007 Jan; 203(1):221-32.
Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff HJ. PMID: 16999955.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
Identification of human alpha-synuclein specific single chain antibodies. Biochem Biophys Res Commun. 2006 Nov 03; 349(4):1198-205.
Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff HJ. PMID: 16973126.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
-
Systems biology: a primer. NeuroRx. 2006 Jul; 3(3):293-4.
Federoff HJ, Mhyre TR. PMID: 16815212; PMCID: PMC3593376.
View in:
PubMed Mentions: Fields:
-
Microarrays in Parkinson's disease: a systematic approach. NeuroRx. 2006 Jul; 3(3):319-26.
Miller RM, Federoff HJ. PMID: 16815215; PMCID: PMC3593377.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
-
HSV amplicons: neuro applications. Curr Gene Ther. 2006 Jun; 6(3):337-50.
Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. PMID: 16787185.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Mol Ther. 2006 Mar; 13(3):580-8.
Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. PMID: 16412694.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons. Neurobiol Dis. 2006 May; 22(2):284-93.
Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff HJ, Cooper JD, Pearce DA. PMID: 16412658; PMCID: PMC3651998.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
CNS gene therapy and a nexus of complexity: systems and biology at a crossroads. Cell Transplant. 2006; 15(3):267-73.
Tyler CM, Federoff HJ. PMID: 16719061.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis. 2006 Jan; 44(1):44-9.
Rempe D, Vangeison G, Hamilton J, Li Y, Jepson M, Federoff HJ. PMID: 16419044.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
-
Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. Neuroscientist. 2005 Dec; 11(6):539-49.
Miller RM, Federoff HJ. PMID: 16282595.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Immune shaping and the development of Alzheimer's disease vaccines. Sci Aging Knowledge Environ. 2005 Nov 16; 2005(46):pe35.
Federoff HJ, Bowers WJ. PMID: 16293586; PMCID: PMC2447918.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Exp Neurol. 2006 Feb; 197(2):347-52.
Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. PMID: 16289170.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Ann Surg Oncol. 2005 Dec; 12(12):1025-36.
Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. PMID: 16244806.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23.
Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. PMID: 16232318; PMCID: PMC1276812.
View in:
PubMed Mentions:
118 Fields:
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Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke. 2005 Oct; 36(10):2232-7.
de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff HJ, Stanton PK, Rozental R. PMID: 16179575.
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PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
-
Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiol Dis. 2006 Feb; 21(2):305-13.
Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff HJ. PMID: 16143538.
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PubMed Mentions:
48 Fields:
Translation:
Humans
-
Alzheimer's disease: reducing the burden with ApoE2. Gene Ther. 2005 Jul; 12(13):1019-29.
Federoff HJ. PMID: 19202630.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiol Aging. 2005 May; 26(5):765-75.
Miller RM, Chen LL, Kiser GL, Giesler TL, Kaysser-Kranich TM, Palaniappan C, Federoff HJ. PMID: 15708451.
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PubMed Mentions:
7 Fields:
Translation:
Animals
-
HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiol Aging. 2005 Apr; 26(4):393-407.
Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. PMID: 15653168.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res. 2005 Mar 24; 134(1):18-23.
Maguire-Zeiss KA, Short DW, Federoff HJ. PMID: 15790526.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimals
-
beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Res Mol Brain Res. 2005 Feb 18; 133(2):286-98.
Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ. PMID: 15710246.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. J Virol. 2005 Feb; 79(4):2124-32.
Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. PMID: 15681415; PMCID: PMC546587.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Novel gene therapeutic strategies for neurodegenerative diseases. Ernst Schering Res Found Workshop. 2005; (53):147-71.
Maguire-Zeiss KA, Federoff HJ. PMID: 16315613.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S43-6.
Henricksen LA, Federoff HJ. PMID: 15665413.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci. 2004 Dec 01; 24(48):10963-73.
Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. PMID: 15574746; PMCID: PMC6730219.
View in:
PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
-
Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. J Gastrointest Surg. 2004 Nov; 8(7):812-22; discussion 822-3.
Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. PMID: 15531234.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004 Oct 12; 63(7):1155-62.
Coleman P, Federoff H, Kurlan R. PMID: 15477531.
View in:
PubMed Mentions:
116 Fields:
Translation:
HumansAnimalsCells
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Safety of viral vectors for neurological gene therapies. Curr Opin Mol Ther. 2004 Oct; 6(5):473-81.
Maguire-Zeiss KA, Federoff HJ. PMID: 15537048.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J Neurosci. 2004 Aug 25; 24(34):7445-54.
Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff HJ. PMID: 15329391; PMCID: PMC6729635.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases. Ann Surg. 2004 Jun; 239(6):892-9; discussion 899-902.
Reinblatt M, Pin RH, Federoff HJ, Fong Y. PMID: 15166969; PMCID: PMC1356298.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. J Neurophysiol. 2004 Oct; 92(4):2394-404.
Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. PMID: 15152019.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest. 2004 Mar; 113(6):876-84.
Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ, Ogawa S. PMID: 15067320; PMCID: PMC362115.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004 Feb; 149(1):1-10.
Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. PMID: 15104276.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Neurotrophin secretory pathways and synaptic plasticity. Neurobiol Aging. 2003 Dec; 24(8):1135-45.
Lim KC, Lim ST, Federoff HJ. PMID: 14643385.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. Brain Res Mol Brain Res. 2003 Nov 06; 119(1):1-9.
Kyrkanides S, Miller JH, Federoff HJ. PMID: 14597224.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Mol Ther. 2003 Nov; 8(5):790-5.
Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. PMID: 14599812.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Exp Neurol. 2003 Sep; 183(1):47-55.
Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. PMID: 12957487.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. J Neurosci. 2003 Aug 13; 23(19):7385-94.
Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. PMID: 12917374; PMCID: PMC6740455.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
-
Current treatment for Alzheimer disease and future prospects. Alzheimer Dis Assoc Disord. 2003 Jul-Sep; 17 Suppl 4:S105-13.
Tariot PN, Federoff HJ. PMID: 14512816.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 2003 Jun 02; 21(19-20):2288-97.
Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. PMID: 12744859.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
-
Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Ther. 2003 Jun; 10(11):941-5.
Bowers WJ, Olschowka JA, Federoff HJ. PMID: 12756414.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Convergent pathobiologic model of Parkinson's disease. Ann N Y Acad Sci. 2003 Jun; 991:152-66.
Maguire-Zeiss KA, Federoff HJ. PMID: 12846984.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
-
Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection. Cancer Gene Ther. 2003 Mar; 10(3):215-23.
Jarnagin WR, Zager JS, Klimstra D, Delman KA, Malhotra S, Ebright M, Little S, DeRubertis B, Stanziale SF, Hezel M, Federoff H, Fong Y. PMID: 12637943.
View in:
PubMed Mentions:
17 Fields:
Translation:
AnimalsCells
-
Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol Ther. 2003 Feb; 7(2):218-27.
Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. PMID: 12597910.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med. 2003 Feb; 9(2):231-5.
Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. PMID: 12539041.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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CNS diseases amenable to gene therapy. Ernst Schering Res Found Workshop. 2003; (43):117-58.
Federoff HJ. PMID: 12894455.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Res. 2002 Nov 15; 62(22):6545-51.
Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. PMID: 12438249.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer. Cancer Gene Ther. 2002 Nov; 9(11):935-45.
Bennett JJ, Delman KA, Burt BM, Mariotti A, Malhotra S, Zager J, Petrowsky H, Mastorides S, Federoff H, Fong Y. PMID: 12386832.
View in:
PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
-
HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Mol Ther. 2002 Oct; 6(4):455-63.
Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. PMID: 12377186.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Amyloid immunotherapy-engendered CNS inflammation. Neurobiol Aging. 2002 Sep-Oct; 23(5):675-6; discussion 683-4.
Bowers WJ, Federoff HJ. PMID: 12392770.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep; 236(3):337-42; discussion 342-3.
Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. PMID: 12192320; PMCID: PMC1422587.
View in:
PubMed Mentions:
10 Fields:
Translation:
Animals
-
Somatic mosaic approaches and the aging brain. Neurobiol Aging. 2002 Sep-Oct; 23(5):977-84.
Maguire-Zeiss KA, Bowers WJ, Federoff HJ. PMID: 12392799.
View in:
PubMed Mentions: Fields:
Translation:
Animals
-
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12; 297(5579):259-63.
Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. PMID: 12114629.
View in:
PubMed Mentions:
644 Fields:
Translation:
AnimalsCells
-
Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol Ther. 2002 Jul; 6(1):12-8.
Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. PMID: 12095298.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. J Virol. 2002 Jun; 76(11):5565-80.
Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. PMID: 11991985; PMCID: PMC137011.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Reporter gene transfer induces apoptosis in primary cortical neurons. Mol Ther. 2002 Jun; 5(6):723-30.
Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. PMID: 12027556.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002 May; 175(1):35-48.
Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ. PMID: 12009758.
View in:
PubMed Mentions:
99 Fields:
Translation:
HumansAnimalsCells
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Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6216-21.
Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff HJ, Davidson BL. PMID: 11959904; PMCID: PMC122929.
View in:
PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
-
Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Mol Ther. 2002 Mar; 5(3):300-6.
Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. PMID: 11863420.
View in:
PubMed Mentions:
6 Fields:
Translation:
Animals
-
Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplant. 2002; 11(4):331-49.
Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ. PMID: 12162374.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77.
Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. PMID: 11807038.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Hum Gene Ther. 2001 Oct 10; 12(15):1867-79.
Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. PMID: 11589829.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. Drug Metab Dispos. 2001 Oct; 29(10):1256-62.
DeCory HH, Piech-Dumas KM, Sheu SS, Federoff HJ, Anders MW. PMID: 11560867.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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HSV vector-mediated gene delivery to the central nervous system. Curr Opin Mol Ther. 2001 Oct; 3(5):482-90.
Maguire-Zeiss KA, Bowers WJ, Federoff HJ. PMID: 11699893.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Mol Ther. 2001 Sep; 4(3):250-6.
Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y. PMID: 11545616.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Regulation of neuronal traits by a novel transcriptional complex. Neuron. 2001 Aug 16; 31(3):353-65.
Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. PMID: 11516394.
View in:
PubMed Mentions:
189 Fields:
Translation:
HumansAnimalsCells
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Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. J Virol. 2001 Aug; 75(15):7050-8.
Petrowsky H, Roberts GD, Kooby DA, Burt BM, Bennett JJ, Delman KA, Stanziale SF, Delohery TM, Tong WP, Federoff HJ, Fong Y. PMID: 11435585; PMCID: PMC114433.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol Med. 2001 Aug; 7(8):561-8.
Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. PMID: 11591892; PMCID: PMC1950059.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 2001 Jul 15; 98(2):287-95.
Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. PMID: 11435295.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer. Nat Med. 2001 Jul; 7(7):859-63.
Bennett JJ, Tjuvajev J, Johnson P, Doubrovin M, Akhurst T, Malholtra S, Hackman T, Balatoni J, Finn R, Larson SM, Federoff H, Blasberg R, Fong Y. PMID: 11433353.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
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HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Mol Ther. 2001 Jun; 3(6):958-63.
Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. PMID: 11407910.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model. FASEB J. 2001 May; 15(7):1306-8.
Cozzi PJ, Malhotra S, McAuliffe P, Kooby DA, Federoff HJ, Huryk B, Johnson P, Scardino PT, Heston WD, Fong Y. PMID: 11344122.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. Surgery. 2001 Mar; 129(3):324-34.
Brooks AD, Ng B, Liu D, Brownlee M, Burt M, Federoff HJ, Fong Y. PMID: 11231461.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 2001 Mar 01; 410(6824):89-93.
Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. PMID: 11242047.
View in:
PubMed Mentions:
80 Fields:
Translation:
AnimalsCells
-
Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Ther. 2001 Jan; 8(2):111-20.
Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. PMID: 11313780.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13378-83.
Brooks AI, Cory-Slechta DA, Federoff HJ. PMID: 11078505; PMCID: PMC27232.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Hum Gene Ther. 2000 Nov 20; 11(17):2341-52.
Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. PMID: 11096439.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory. Neurobiol Learn Mem. 2000 Nov; 74(3):241-58.
Brooks AI, Cory-Slechta DA, Murg SL, Federoff HJ. PMID: 11031130.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Effective treatment of pancreatic tumors with two multimutated herpes simplex oncolytic viruses. J Gastrointest Surg. 2000 Nov-Dec; 4(6):580-8.
McAuliffe PF, Jarnagin WR, Johnson P, Delman KA, Federoff H, Fong Y. PMID: 11307092.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro. Neurobiol Dis. 2000 Aug; 7(4):362-74.
Telfeian AE, Federoff HJ, Leone P, During MJ, Williamson A. PMID: 10964607.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. Ann Surg. 2000 May; 231(5):762-71.
Jarnagin WR, Delman K, Kooby D, Mastorides S, Zager J, Brennan MF, Blumgart LH, Federoff H, Fong Y. PMID: 10767798; PMCID: PMC1421064.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Efficient cotransduction of tumors by multiple herpes simplex vectors: implications for tumor vaccine production. Cancer Gene Ther. 2000 Apr; 7(4):581-8.
Karpoff HM, Kooby D, D'Angelica M, Mack J, Presky DH, Brownlee MD, Federoff H, Fong Y. PMID: 10811476.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Mol Ther. 2000 Mar; 1(3):294-9.
Bowers WJ, Howard DF, Federoff HJ. PMID: 10933945.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer. J Mol Med (Berl). 2000; 78(3):166-74.
Bennett JJ, Kooby DA, Delman K, McAuliffe P, Halterman MW, Federoff H, Fong Y. PMID: 10868479.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Novel targets for CNS gene therapy. Gene Ther. 1999 Dec; 6(12):1907-8.
Federoff HJ. PMID: 10637440.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Gene therapy in the inner ear. Mechanisms and clinical implications. Ann N Y Acad Sci. 1999 Nov 28; 884:345-60.
Van de Water TR, Staecker H, Halterman MW, Federoff HJ. PMID: 10842605.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol. 1999 Sep; 159(1):65-72.
Halterman MW, Federoff HJ. PMID: 10486175.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity. Mol Med. 1999 Sep; 5(9):606-16.
D'Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. PMID: 10551902; PMCID: PMC2230459.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci. 1999 Aug 15; 19(16):6818-24.
Halterman MW, Miller CC, Federoff HJ. PMID: 10436039; PMCID: PMC6782875.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). FASEB J. 1999 Aug; 13(11):1325-34.
Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y. PMID: 10428757.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Hum Gene Ther. 1999 Jul 01; 10(10):1599-606.
Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. PMID: 10428205.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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An infectious conspiracy: the case for HSV-1 and APOEepsilon4 in Alzheimer's disease. Neurobiol Aging. 1999 Jul-Aug; 20(4):467-8.
Federoff HJ. PMID: 10604442.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Lentivirus vectors using human and simian immunodeficiency virus elements. J Virol. 1999 Apr; 73(4):2832-40.
White SM, Renda M, Nam NY, Klimatcheva E, Zhu Y, Fisk J, Halterman M, Rimel BJ, Federoff H, Pandya S, Rosenblatt JD, Planelles V. PMID: 10074131; PMCID: PMC104041.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res. 1999 Mar 27; 823(1-2):1-10.
Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff HJ. PMID: 10095006.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
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BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Exp Neurol. 1999 Mar; 156(1):130-7.
Antonawich FJ, Federoff HJ, Davis JN. PMID: 10192784.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro. J Gastrointest Surg. 1999 Mar-Apr; 3(2):127-31; discussion 132-3.
Lee JH, Federoff HJ, Schoeniger LO. PMID: 10457334.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 1999 Feb 05; 10(2):337-44.
Brooks AI, Halterman MW, Federoff HJ. PMID: 10203332.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 1999 Jan 15; 93(2):643-54.
Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. PMID: 9885227.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors. Cancer Immunol Immunother. 1999 Jan; 47(5):265-71.
D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y. PMID: 10022470; PMCID: PMC11037327.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. Am J Surg. 1998 Nov; 176(5):404-8.
Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y. PMID: 9874422.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse. J Physiol. 1998 Nov 01; 512 ( Pt 3):779-91.
Heath BM, Xia J, Dong E, An RH, Brooks A, Liang C, Federoff HJ, Kass RS. PMID: 9769421; PMCID: PMC2231244.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption. J Neurosci Methods. 1998 Sep 01; 83(2):159-64.
Deng SX, Panahian N, James H, Gelbard HA, Federoff HJ, Dewhurst S, Epstein LG. PMID: 9765129.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg. 1998 Jul; 119(1):7-13.
Staecker H, Gabaizadeh R, Federoff H, Van De Water TR. PMID: 9674508.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Am J Pathol. 1998 Jun; 152(6):1521-9.
Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF. PMID: 9626056; PMCID: PMC1858445.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. J Neurosci Methods. 1998 Apr 30; 80(2):137-47.
Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ. PMID: 9667386.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Towards gene therapy of neurodegenerative disease. Prog Brain Res. 1998; 117:503-10.
Federoff HJ, Atkinson M. PMID: 9932428.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Topical application of viral vectors for epidermal gene transfer. J Invest Dermatol. 1997 May; 108(5):803-8.
Lu B, Federoff HJ, Wang Y, Goldsmith LA, Scott G. PMID: 9129236.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Exp Neurol. 1997 Mar; 144(1):58-68.
Bowers WJ, Howard DF, Federoff HJ. PMID: 9126153.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon. J Clin Invest. 1997 Feb 15; 99(4):799-804.
Karpoff HM, D'Angelica M, Blair S, Brownlee MD, Federoff H, Fong Y. PMID: 9045885; PMCID: PMC507865.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nat Biotechnol. 1997 Jan; 15(1):57-62.
Brooks AI, Muhkerjee B, Panahian N, Cory-Slechta D, Federoff HJ. PMID: 9035107.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Somatic gene transfer approaches to manipulate neural networks. J Neurosci Methods. 1997 Jan; 71(1):133-42.
Federoff HJ, Brooks A, Muhkerjee B, Corden T. PMID: 9125382.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production. Hum Gene Ther. 1996 Dec 01; 7(18):2217-24.
Tung C, Federoff HJ, Brownlee M, Karpoff H, Weigel T, Brennan MF, Fong Y. PMID: 8953312.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Hum Gene Ther. 1996 Oct 20; 7(16):2015-24.
Jin BK, Belloni M, Conti B, Federoff HJ, Starr R, Son JH, Baker H, Joh TH. PMID: 8930662.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum Gene Ther. 1996 Sep 10; 7(14):1719-26.
Liu Y, Rabinovitch A, Suarez-Pinzon W, Muhkerjee B, Brownlee M, Edelstein D, Federoff HJ. PMID: 8886842.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Mol Cell Neurosci. 1996 Mar; 7(3):222-38.
Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. PMID: 8726105.
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PubMed Mentions:
110 Fields:
Translation:
HumansAnimalsCells
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Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. Hum Gene Ther. 1996 Jan 20; 7(2):173-82.
Geschwind MD, Hartnick CJ, Liu W, Amat J, Van De Water TR, Federoff HJ. PMID: 8788168.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors. Hepatology. 1995 Sep; 22(3):723-9.
Fong Y, Federoff HJ, Brownlee M, Blumberg D, Blumgart LH, Brennan MF. PMID: 7657275.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke. 1995 Sep; 26(9):1670-4; discussion 1675.
Linnik MD, Zahos P, Geschwind MD, Federoff HJ. PMID: 7544927.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med. 1995 Jul; 1(5):527-34.
Hammes HP, Federoff HJ, Brownlee M. PMID: 8529118; PMCID: PMC2229962.
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PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
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Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice. Dev Biol. 1995 Jun; 169(2):533-46.
Andrade-Rozental AF, Rozental R, Hassankhani A, Spray DC, Federoff HJ. PMID: 7781897.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit. Neurosci Lett. 1995 May 19; 191(1-2):67-70.
Casaccia-Bonnefil P, Stelzer A, Federoff HJ, Bergold PJ. PMID: 7659294.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev Biol. 1995 May; 169(1):309-21.
Hassankhani A, Steinhelper ME, Soonpaa MH, Katz EB, Taylor DA, Andrade-Rozental A, Factor SM, Steinberg JJ, Field LJ, Federoff HJ. PMID: 7750647.
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PubMed Mentions:
47 Fields:
Translation:
AnimalsCells
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Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. Hum Gene Ther. 1995 Apr; 6(4):419-28.
Lu B, Federoff HJ. PMID: 7612699.
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PubMed Mentions:
9 Fields:
Translation:
Cells
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Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector. Hepatology. 1995 Mar; 21(3):752-9.
Lu B, Gupta S, Federoff H. PMID: 7875674.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia. Neurosci Lett. 1995 Feb 17; 186(2-3):157-60.
Volpe BT, Wessel TC, Mukherjee B, Federoff HJ. PMID: 7777186.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circ Res. 1995 Feb; 76(2):161-7.
Mesri EA, Federoff HJ, Brownlee M. PMID: 7530606.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Brain Res Mol Brain Res. 1994 Jul; 24(1-4):327-35.
Geschwind MD, Kessler JA, Geller AI, Federoff HJ. PMID: 7968372.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness. Dev Biol. 1994 May; 163(1):152-61.
Xu H, Federoff H, Maragos J, Parada LF, Kessler JA. PMID: 8174770.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Functional characterization of the rat GAP-43 promoter. Brain Res. 1994 Feb 28; 638(1-2):211-20.
Starr RG, Lu B, Federoff HJ. PMID: 8199862.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):519-23.
De Leon JR, Federoff HJ, Dickson DW, Vikstrom KL, Fishman GI. PMID: 8290557; PMCID: PMC42980.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Nerve growth factor administration protects against experimental diabetic sensory neuropathy. Brain Res. 1994 Jan 14; 634(1):7-12.
Apfel SC, Arezzo JC, Brownlee M, Federoff H, Kessler JA. PMID: 7512429.
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PubMed Mentions:
52 Fields:
Translation:
Animals
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Stimulation of neurite growth rat adrenal chromaffin cells infected with a defective herpes simplex virus carrying an NGF minigene. Gene Ther. 1994; 1 Suppl 1:S70.
Bohn MC, Lin Q, Federoff HJ. PMID: 8542416.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices. J Neurosci Methods. 1993 Dec; 50(3):341-51.
Casaccia-Bonnefil P, Benedikz E, Shen H, Stelzer A, Edelstein D, Geschwind M, Brownlee M, Federoff HJ, Bergold PJ. PMID: 8152244.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain. Brain Res Mol Brain Res. 1993 Oct; 20(1-2):101-10.
Lustig RH, Hua P, Wilson MC, Federoff HJ. PMID: 8255171.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6165-9.
Bergold PJ, Casaccia-Bonnefil P, Zeng XL, Federoff HJ. PMID: 8392189; PMCID: PMC46888.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth. Diabetes. 1993 Apr; 42(4):509-13.
Federoff HJ, Lawrence D, Brownlee M. PMID: 8454100.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1636-40.
Federoff HJ, Geschwind MD, Geller AI, Kessler JA. PMID: 1311846; PMCID: PMC48507.
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PubMed Mentions:
23 Fields:
Translation:
Cells
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Estrogenic regulation and sex dimorphism of growth-associated protein 43 kDa (GAP-43) messenger RNA in the rat. Brain Res Mol Brain Res. 1991 Sep; 11(2):125-32.
Lustig RH, Sudol M, Pfaff DW, Federoff HJ. PMID: 1661809.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea. J Clin Endocrinol Metab. 1990 Feb; 70(2):311-7.
Biller BM, Federoff HJ, Koenig JI, Klibanski A. PMID: 2153693.
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PubMed Mentions:
29 Fields:
Translation:
Humans
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Cloning and Characterization of the Rat Gene Encoding GAP-43. Eur J Neurosci. 1990; 2(10):822-827.
Grabczyk E, Zuber MX, Federoff HJ, Ng SC, Pack A, Fishman MC. PMID: 12106089.
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PubMed Mentions:
4
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GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system. Brain Res Dev Brain Res. 1989 Apr 01; 46(2):161-8.
De la Monte SM, Federoff HJ, Ng SC, Grabczyk E, Fishman MC. PMID: 2720952.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids. J Biol Chem. 1988 Dec 25; 263(36):19290-5.
Federoff HJ, Grabczyk E, Fishman MC. PMID: 2461937.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis. J Bacteriol. 1983 Oct; 156(1):301-7.
Federoff HJ, Eccleshall TR, Marmur J. PMID: 6352680; PMCID: PMC215083.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Regulation of maltase synthesis in Saccharomyces carlsbergensis. J Bacteriol. 1983 Jun; 154(3):1301-8.
Federoff HJ, Eccleshall TR, Marmur J. PMID: 6343348; PMCID: PMC217604.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Isolation of a maltase structural gene from Saccharomyces carlsbergensis. J Bacteriol. 1982 Mar; 149(3):1064-70.
Federoff HJ, Cohen JD, Eccleshall TR, Needleman RB, Buchferer BA, Giacalone J, Marmur J. PMID: 7037739; PMCID: PMC216496.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):1078-82.
Cohen JD, Eccleshall TR, Needleman RB, Federoff H, Buchferer BA, Marmur J. PMID: 6987664; PMCID: PMC348427.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Purification and characterization of an alpha-glucosidase from Saccharomyces carlsbergensis. Biochemistry. 1978 Oct 31; 17(22):4657-61.
Needleman RB, Federoff HJ, Eccleshall TR, Buchferer B, Marmur J. PMID: 365220.
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PubMed Mentions:
19 Fields:
Translation:
Animals