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Federoff, Howard J

Title(s)Professor, Neurology
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    Collapse Research 
    Collapse Research Activities and Funding
    MECHANICAL SYSTEMS RENOVATION
    NIH/NCRR G20RR030966Apr 21, 2010 - Dec 20, 2014
    Role: Principal Investigator
    A Novel Monkey Model for Parkinson's Drug Discovery
    NIH/NINDS RC2NS069450Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Dopamine, mutant synuclein, oxidative stress and inflammation
    NIH/NINDS R01NS057267Sep 15, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Leukocyte-derived Biomarkers as Predictors of Risk and Progression in AD
    NIH/NIA R01AG030753May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Peripheral Macrophage Signatures of Inflammation in Neurodegenerative Diseases
    NIH/NINDS R21NS060213Sep 30, 2007 - Jul 31, 2010
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR023942May 1, 2007 - Jun 30, 2010
    Role: Principal Investigator
    Nectin-1: Synaptic processing and functions
    NIH/NIA R01AG027233Mar 15, 2006 - Jan 31, 2012
    Role: Principal Investigator
    Proteomic Biomarker Discovery in PD
    NIH/NINDS R21NS052151Aug 22, 2005 - Feb 28, 2009
    Role: Principal Investigator
    Peripheral Leukocyte Biomarkers in Alzheimer's Disease
    NIH/NIA R21AG025354Sep 30, 2004 - Jun 30, 2007
    Role: Principal Investigator
    HSV Amplicon-mediated Disruption of Abeta Fibrillogenesis
    NIH/NIA R01AG020204Sep 30, 2003 - Jul 31, 2007
    Role: Principal Investigator
    Parkinson's Disease Gene Therapy Study Group
    NIH/NINDS U54NS045309Sep 30, 2002 - Aug 31, 2009
    Role: Principal Investigator
    Single-chain Antibody Therapy for Prion Disease
    NIH/NIA R21AG021610Sep 30, 2002 - Aug 31, 2004
    Role: Principal Investigator
    Interdepartmental Neuroscience Training
    NIH/NINDS T32NS007489Sep 30, 2000 - Jun 30, 2015
    Role: Co-Principal Investigator
    ROCHESTER NATHAN SHOCK CENTER
    NIH/NIA P30AG018254Sep 1, 2000 - Jun 30, 2006
    Role: Principal Investigator
    METHODS FOR ANALYSIS OF GENE FUNCTION IN NEURAL NETWORKS
    NIH/NIA R01AG018231Apr 15, 2000 - Mar 31, 2004
    Role: Principal Investigator
    ENVIRONMENTAL NEUROTOXICANT GENETIC ACTION--MURINE MODEL
    NIH/NIEHS R01ES009391May 1, 1998 - Apr 30, 2004
    Role: Principal Investigator
    NEW HSV1 VECTORS FOR LONG TERM GENE EXPRESSION
    NIH/NIDDK R21DK053160Sep 30, 1997 - Aug 31, 2000
    Role: Principal Investigator
    Improved HSV Vectors: Gene Transfer into Nervous System
    NIH/NINDS R01NS036420Apr 1, 1997 - Aug 31, 2007
    Role: Principal Investigator
    SOMATIC MOSAIC ANALYSIS OF NGF FUNCTION IN MICE
    NIH/NIMH R01MH057047Apr 1, 1997 - Mar 31, 2002
    Role: Principal Investigator
    GENE THERAPY FOR THE REHABILITATION OF NEUROLOGIC INJURY
    NIH/NICHD R01HD031300Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    MOLECULAR APPROACH TO REGULATION OF SYNAPSE FORMATION
    NIH/NICHD R29HD027116Dec 1, 1989 - Nov 30, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Adelman ZN, Albritton LM, Boris-Lawrie K, Buchmeier MJ, Cannon P, Cho M, DiGiusto D, Donahue JK, Federoff HJ, Hammarskjold ML, Hardison AD, Hearing P, Lee B, Lee DA, Porteus MH, Ross LF, Ross SR, Wooley DP, Zoloth L. Protect NIH's DNA advisory committee. Science. 2018 10 26; 362(6413):409-410. PMID: 30361364.
      View in: PubMed
    2. Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury. Metabolites. 2018 Sep 07; 8(3). PMID: 30205491.
      View in: PubMed
    3. Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW. Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep. 2018 Aug 22; 8(1):12558. PMID: 30135469.
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    4. Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ. Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018; 13(4):e0195318. PMID: 29677216.
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    5. Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S. Precision pharmacology for Alzheimer's disease. Pharmacol Res. 2018 04; 130:331-365. PMID: 29458203.
      View in: PubMed
    6. Gross T, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS. Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development. Curr Top Med Chem. 2018; 18(11):883-895. PMID: 29992885.
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    7. Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki ES, Malik S, Macciardi F, Federoff HJ. Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017 Dec 19; 11(1):142. PMID: 29258513.
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    8. Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, Cheema AK. Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget. 2017 Sep 15; 8(40):68899-68915. PMID: 28978166.
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    9. Chapman BP, Benedict RHB, Lin F, Roy S, Porteinsson A, Szigeti K, Federoff H, Mapstone M. Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype. Int J Geriatr Psychiatry. 2018 02; 33(2):332-339. PMID: 28612377.
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    10. Subramaniam SR, Federoff HJ. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Front Aging Neurosci. 2017; 9:176. PMID: 28642697.
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    11. Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff HJ. Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models. Mol Ther. 2017 10 04; 25(10):2231-2235. PMID: 28522034.
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    12. Chapman BP, Benedict RH, Lin F, Roy S, Federoff HJ, Mapstone M. Personality and Performance in Specific Neurocognitive Domains Among Older Persons. Am J Geriatr Psychiatry. 2017 Aug; 25(8):900-908. PMID: 28456386.
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    13. Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff HJ. Biomarker validation: Methods and matrix matter. Alzheimers Dement. 2017 05; 13(5):608-609. PMID: 28010950.
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    14. Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-ß and Interleukin-4. Mol Ther. 2008 May; 16(5):845-853. PMID: 28178487.
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    15. Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Mol Ther. 2008 Apr; 16(4):640-646. PMID: 28178462.
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    16. Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 03; 51:148-155. PMID: 27939698.
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    17. Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H. A genome-wide association study in multiple system atrophy. Neurology. 2016 Oct 11; 87(15):1591-1598. PMID: 27629089.
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    18. Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Front Neurol. 2015; 6:237. PMID: 26617567; PMCID: PMC4642213.
    19. Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff HJ. PGC-1a Promoter Methylation in Parkinson's Disease. PLoS One. 2015; 10(8):e0134087. PMID: 26317511; PMCID: PMC4552803.
    20. Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 2015 Oct; 14(10):1002-9. PMID: 26271532.
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    21. Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff HJ, Newport EL. Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci. 2015; 9:231. PMID: 25972803; PMCID: PMC4413691.
    22. Cheever TR, Berkley D, Braun S, Brown RH, Byrne BJ, Chamberlain JS, Cwik V, Duan D, Federoff HJ, High KA, Kaspar BK, Klinger KW, Larkindale J, Lincecum J, Mavilio F, McDonald CL, McLaughlin J, Weiss McLeod B, Mendell JR, Nuckolls G, Stedman HH, Tagle DA, Vandenberghe LH, Wang H, Wernett PJ, Wilson JM, Porter JD, Gubitz AK. Perspectives on best practices for gene therapy programs. Hum Gene Ther. 2015 Mar; 26(3):127-33. PMID: 25654329; PMCID: PMC4367233.
    23. Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82. PMID: 25473422.
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    24. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1. PMID: 25130657.
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    25. Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S196-212. PMID: 24924671.
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    26. O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97. PMID: 24773122; PMCID: PMC4064731.
    27. Su X, Federoff HJ. Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Res Int. 2014; 2014:275178. PMID: 24822191; PMCID: PMC4005076.
    28. Federoff HJ, Wagner JE. The evolution of gene transfer, gene therapy, and the RAC: IOM recommendations to the NIH director. Mol Ther. 2014 Apr; 22(4):685-6. PMID: 24691174; PMCID: PMC3982498.
    29. Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr; 20(4):415-8. PMID: 24608097.
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    30. Huang L, Shimoji M, Wang J, Shah S, Kamila S, Biehl ER, Lim S, Chang A, Maguire-Zeiss KA, Su X, Federoff HJ. Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics. 2013 Oct; 10(4):840-51. PMID: 23963789; PMCID: PMC3805857.
    31. Huang L, Su X, Federoff HJ. Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. Int J Mol Sci. 2013 Sep 17; 14(9):19109-27. PMID: 24048248; PMCID: PMC3794823.
    32. MacArthur L, Ressom H, Shah S, Federoff HJ. Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease. Expert Rev Neurother. 2013 Jun; 13(6):685-93. PMID: 23739005.
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    33. Fiandaca MS, Federoff HJ. Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding? Exp Neurol. 2014 Jun; 256:117-25. PMID: 23524194.
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    34. Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA. Microglial activation and antioxidant responses induced by the Parkinson's disease protein a-synuclein. J Neuroimmune Pharmacol. 2013 Mar; 8(1):94-117. PMID: 23054368; PMCID: PMC3582877.
    35. Galpern WR, Corrigan-Curay J, Lang AE, Kahn J, Tagle D, Barker RA, Freeman TB, Goetz CG, Kieburtz K, Kim SY, Piantadosi S, Comstock Rick A, Federoff HJ. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet Neurol. 2012 Jul; 11(7):643-50. PMID: 22710757.
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    36. Scholz SW, Mhyre T, Ressom H, Shah S, Federoff HJ. Genomics and bioinformatics of Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a009449. PMID: 22762024; PMCID: PMC3385936.
    37. Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff HJ, Traynor BJ, Singleton AB, Houlden H. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 2012 Jul 10; 79(2):127-31. PMID: 22675081; PMCID: PMC3390538.
    38. Fiandaca MS, Bankiewicz KS, Federoff HJ. Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel). 2012 Jun 04; 5(6):553-90. PMID: 24281662; PMCID: PMC3763661.
    39. Sanberg PR, Federoff HJ. EDITORIAL: TECHNOLOGY, INNOVATION, AND HEALTH. Technol Innov. 2012 Apr 01; 13(4):261-262. PMID: 24744821.
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    40. Sanberg PR, Federoff HJ. TECHNOLOGY AND INVENTION. Technol Innov. 2012; 14(1):1-2. PMID: 25254084.
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    41. Lim ST, Chang A, Giuliano RE, Federoff HJ. Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density. J Neurochem. 2012 Mar; 120(5):741-51. PMID: 22118475.
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    42. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. PMID: 22132130; PMCID: PMC3221672.
    43. Kim J, Chang A, Dudak A, Federoff HJ, Lim ST. Characterization of nectin processing mediated by presenilin-dependent ?-secretase. J Neurochem. 2011 Dec; 119(5):945-56. PMID: 21910732; PMCID: PMC3217175.
    44. Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. Eur J Neurosci. 2011 Oct; 34(8):1256-67. PMID: 21995852; PMCID: PMC3195885.
    45. Rogawski MA, Federoff HJ. Disclosure of clinical trial results when product development is abandoned. Sci Transl Med. 2011 Sep 28; 3(102):102cm29. PMID: 21957167.
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    46. Dudak A, Kim J, Cheong B, Federoff HJ, Lim ST. Membrane palmitoylated proteins regulate trafficking and processing of nectins. Eur J Cell Biol. 2011 May; 90(5):365-75. PMID: 21371776; PMCID: PMC3060411.
    47. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57. PMID: 21343917; PMCID: PMC3129792.
    48. Shah S, Federoff HJ. Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy. 2011 Feb; 3(2):287-98. PMID: 21322764.
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    49. Sanberg PR, Vindrola-Padros C, Eve DJ, Federoff HJ. Technology and innovation: 2010 a year in review. Cell Transplant. 2011; 20(8):1315-9. PMID: 22080749.
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    50. Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):852-7. PMID: 21187387; PMCID: PMC3021064.
    51. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR. PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 06; 2(52):52ra73. PMID: 20926834; PMCID: PMC3129986.
    52. Federoff HJ, Rubin ER. A new research and development policy framework for the biomedical research enterprise. JAMA. 2010 Sep 01; 304(9):1003-4. PMID: 20810378.
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    53. Sistrunk SI, Kumar P, Walther J, Gwinn L, Williams J, Moore ES, Frank I, Weissinger P, Brown LW, Mitchell SR, Federoff HJ. Georgetown University School of Medicine. Acad Med. 2010 Sep; 85(9 Suppl):S131-5. PMID: 20736531.
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    54. Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med. 2010 Sep; 16(9):998-1000. PMID: 20729864.
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    55. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. PMID: 20631185; PMCID: PMC2914692.
    56. Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol Ther. 2010 Aug; 18(8):1471-81. PMID: 20551911; PMCID: PMC2927061.
    57. Feng LR, Federoff HJ, Vicini S, Maguire-Zeiss KA. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010 Jul; 32(1):10-7. PMID: 20550572; PMCID: PMC2900531.
    58. Maguire-Zeiss KA, Federoff HJ. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. J Neural Transm (Vienna). 2010 Aug; 117(8):1019-25. PMID: 20549523.
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    59. Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST. Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem. 2010 Jul 23; 285(30):22919-26. PMID: 20501653; PMCID: PMC2906284.
    60. Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J Neurosci Methods. 2010 Jul 15; 190(2):171-9. PMID: 20452375; PMCID: PMC2902796.
    61. Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. J Biol Chem. 2010 Jul 09; 285(28):21329-40. PMID: 20448044; PMCID: PMC2898390.
    62. Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS One. 2010 Feb 02; 5(2):e9002. PMID: 20126313; PMCID: PMC2814869.
    63. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. PMID: 19671001; PMCID: PMC2861959.
    64. Zaia JA, Federoff HJ. Death in a gene-therapy trial. N Engl J Med. 2009 Oct 29; 361(18):1811. PMID: 19864684.
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    65. Shah S, Federoff HJ. Drug discovery dilemma and Cura quartet collaboration. Drug Discov Today. 2009 Nov; 14(21-22):1006-10. PMID: 19815089.
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    66. Luo Y, Sarabi SA, Backman C, Shan L, Hoffer B, Federoff H. Expression pattern of NuIP gene in adult mouse brain. Brain Res. 2009 Dec 11; 1302:42-53. PMID: 19765553.
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    67. Federoff HJ, Gostin LO. Evolving from reductionism to holism: is there a future for systems medicine? JAMA. 2009 Sep 02; 302(9):994-6. PMID: 19724047.
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    68. Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Mol Ther. 2009 Dec; 17(12):2031-40. PMID: 19638957; PMCID: PMC2788047.
    69. Federoff HJ. Development of vaccination approaches for the treatment of neurological diseases. J Comp Neurol. 2009 Jul 01; 515(1):4-14. PMID: 19399901.
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    70. Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol. 2009 Jun 15; 185(6):1065-81. PMID: 19528298; PMCID: PMC2711615.
    71. Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Hum Gene Ther. 2009 May; 20(5):442-52. PMID: 19199821; PMCID: PMC2828628.
    72. Ryan DA, Federoff HJ. Immune responses to herpesviral vectors. Hum Gene Ther. 2009 May; 20(5):434-41. PMID: 19216681; PMCID: PMC2828622.
    73. Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):511-8. PMID: 19254173; PMCID: PMC2725183.
    74. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. PMID: 19203243; PMCID: PMC2767387.
    75. Su X, Federoff HJ, Maguire-Zeiss KA. Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox Res. 2009 Oct; 16(3):238-54. PMID: 19526281; PMCID: PMC2877375.
    76. Federoff HJ. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotox Res. 2009 Oct; 16(3):261-70. PMID: 19526279.
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    77. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
    78. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82. PMID: 18974297; PMCID: PMC2626388.
    79. Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009 Apr 02; 113(14):3264-75. PMID: 18952891; PMCID: PMC3401030.
    80. Maguire-Zeiss KA, Federoff HJ. Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases. J Neuroimmune Pharmacol. 2009 Sep; 4(3):298-308. PMID: 18931916; PMCID: PMC2879638.
    81. Luo Y, Xing F, Guiliano R, Federoff HJ. Identification of a novel nurr1-interacting protein. J Neurosci. 2008 Sep 10; 28(37):9277-86. PMID: 18784308.
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    82. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. PMID: 18545225; PMCID: PMC2725180.
    83. Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene delivery to the nervous system. Mol Ther. 2008 Apr; 16(4):640-6. PMID: 18362921; PMCID: PMC2630580.
    84. Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol Ther. 2008 May; 16(5):845-53. PMID: 18388924; PMCID: PMC2441486.
    85. Lim ST, Lim KC, Giuliano RE, Federoff HJ. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol. 2008 Mar 10; 507(2):1228-44. PMID: 18181141.
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    86. Vangeison G, Carr D, Federoff HJ, Rempe DA. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. J Neurosci. 2008 Feb 20; 28(8):1988-93. PMID: 18287515.
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    87. Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci. 2008 Jun; 38(2):125-37. PMID: 18439838; PMCID: PMC2652244.
    88. Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. J Gene Med. 2008 Feb; 10(2):152-64. PMID: 18058952; PMCID: PMC2440655.
    89. Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6. PMID: 18180775.
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    90. Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother. 2008 May; 57(5):663-75. PMID: 17952436.
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    91. Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res. 2007 Oct 15; 67(20):10027-37. PMID: 17942937.
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    92. Maguire-Zeiss KA, Mhyre TR, Federoff HJ. Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Exp Neurol. 2008 Jan; 209(1):101-13. PMID: 18035353.
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    93. Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 2007 Oct 16; 25(42):7410-21. PMID: 17868958; PMCID: PMC2092414.
    94. Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Mol Ther. 2007 Oct; 15(10):1848-55. PMID: 17653102; PMCID: PMC2587304.
    95. Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ. Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun. 2007 Sep 28; 361(3):599-604. PMID: 17673176.
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    96. Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. J Virol Methods. 2007 Oct; 145(1):37-46. PMID: 17606303; PMCID: PMC2080840.
    97. Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging. 2008 Nov; 29(11):1690-701. PMID: 17537546; PMCID: PMC2621109.
    98. Mhyre TR, Loy R, Tariot PN, Profenno LA, Maguire-Zeiss KA, Zhang D, Coleman PD, Federoff HJ. Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. Neurobiol Aging. 2008 Nov; 29(11):1631-43. PMID: 17521776; PMCID: PMC2621111.
    99. Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD, Pearce DA. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Res. 2007 Aug 08; 1162:98-112. PMID: 17617387; PMCID: PMC4790084.
    100. Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem. 2007 Jun 01; 282(22):16187-201. PMID: 17420250.
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    101. Ryan DA, Federoff HJ. Translational considerations for CNS gene therapy. Expert Opin Biol Ther. 2007 Mar; 7(3):305-18. PMID: 17309323.
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    102. Federoff HJ, Mhyre TR. Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Neuron. 2007 Feb 01; 53(3):315-7. PMID: 17270727.
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    103. Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Hum Gene Ther. 2007 Feb; 18(2):93-105. PMID: 17298238.
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    104. Miller RM, Kiser GL, Kaysser-Kranich T, Casaceli C, Colla E, Lee MK, Palaniappan C, Federoff HJ. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Exp Neurol. 2007 Mar; 204(1):421-32. PMID: 17254569.
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    105. Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Res. 2007 Feb 23; 1134(1):33-44. PMID: 17196186; PMCID: PMC2041451.
    106. Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 2007 Feb 19; 25(9):1634-46. PMID: 17145123; PMCID: PMC1851942.
    107. Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff HJ. VIP is a transcriptional target of Nurr1 in dopaminergic cells. Exp Neurol. 2007 Jan; 203(1):221-32. PMID: 16999955.
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    108. Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff HJ. Identification of human alpha-synuclein specific single chain antibodies. Biochem Biophys Res Commun. 2006 Nov 03; 349(4):1198-205. PMID: 16973126.
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    109. Miller RM, Federoff HJ. Microarrays in Parkinson's disease: a systematic approach. NeuroRx. 2006 Jul; 3(3):319-26. PMID: 16815215; PMCID: PMC3593377.
    110. Federoff HJ, Mhyre TR. Systems biology: a primer. NeuroRx. 2006 Jul; 3(3):293-4. PMID: 16815212; PMCID: PMC3593376.
    111. Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. HSV amplicons: neuro applications. Curr Gene Ther. 2006 Jun; 6(3):337-50. PMID: 16787185.
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    112. Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff HJ, Cooper JD, Pearce DA. Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons. Neurobiol Dis. 2006 May; 22(2):284-93. PMID: 16412658; PMCID: PMC3651998.
    113. Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Mol Ther. 2006 Mar; 13(3):580-8. PMID: 16412694.
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    114. Tyler CM, Federoff HJ. CNS gene therapy and a nexus of complexity: systems and biology at a crossroads. Cell Transplant. 2006; 15(3):267-73. PMID: 16719061.
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    115. Miller RM, Federoff HJ. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. Neuroscientist. 2005 Dec; 11(6):539-49. PMID: 16282595.
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    116. Federoff HJ, Bowers WJ. Immune shaping and the development of Alzheimer's disease vaccines. Sci Aging Knowledge Environ. 2005 Nov 16; 2005(46):pe35. PMID: 16293586; PMCID: PMC2447918.
    117. Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Exp Neurol. 2006 Feb; 197(2):347-52. PMID: 16289170.
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    118. Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Ann Surg Oncol. 2005 Dec; 12(12):1025-36. PMID: 16244806.
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    119. Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23. PMID: 16232318; PMCID: PMC1276812.
    120. de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff HJ, Stanton PK, Rozental R. Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke. 2005 Oct; 36(10):2232-7. PMID: 16179575.
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    121. Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff HJ. Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiol Dis. 2006 Feb; 21(2):305-13. PMID: 16143538.
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    122. Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiol Aging. 2005 Apr; 26(4):393-407. PMID: 15653168.
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    123. Maguire-Zeiss KA, Short DW, Federoff HJ. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res. 2005 Mar 24; 134(1):18-23. PMID: 15790526.
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    124. Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ. beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Res Mol Brain Res. 2005 Feb 18; 133(2):286-98. PMID: 15710246.
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    125. Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. J Virol. 2005 Feb; 79(4):2124-32. PMID: 15681415; PMCID: PMC546587.
    126. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci. 2004 Dec 01; 24(48):10963-73. PMID: 15574746.
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    127. Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. J Gastrointest Surg. 2004 Nov; 8(7):812-22; discussion 822-3. PMID: 15531234.
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    128. Coleman P, Federoff H, Kurlan R. A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004 Oct 12; 63(7):1155-62. PMID: 15477531.
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    129. Maguire-Zeiss KA, Federoff HJ. Safety of viral vectors for neurological gene therapies. Curr Opin Mol Ther. 2004 Oct; 6(5):473-81. PMID: 15537048.
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    130. Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff HJ. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J Neurosci. 2004 Aug 25; 24(34):7445-54. PMID: 15329391.
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    131. Reinblatt M, Pin RH, Federoff HJ, Fong Y. Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases. Ann Surg. 2004 Jun; 239(6):892-9; discussion 899-902. PMID: 15166969; PMCID: PMC1356298.
    132. Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. J Neurophysiol. 2004 Oct; 92(4):2394-404. PMID: 15152019.
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    133. Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ, Ogawa S. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest. 2004 Mar; 113(6):876-84. PMID: 15067320; PMCID: PMC362115.
    134. Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004 Feb; 149(1):1-10. PMID: 15104276.
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    135. Lim KC, Lim ST, Federoff HJ. Neurotrophin secretory pathways and synaptic plasticity. Neurobiol Aging. 2003 Dec; 24(8):1135-45. PMID: 14643385.
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    136. Kyrkanides S, Miller JH, Federoff HJ. Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. Brain Res Mol Brain Res. 2003 Nov 06; 119(1):1-9. PMID: 14597224.
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    137. Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Mol Ther. 2003 Nov; 8(5):790-5. PMID: 14599812.
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    138. Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. J Neurosci. 2003 Aug 13; 23(19):7385-94. PMID: 12917374.
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    139. Tariot PN, Federoff HJ. Current treatment for Alzheimer disease and future prospects. Alzheimer Dis Assoc Disord. 2003 Jul-Sep; 17 Suppl 4:S105-13. PMID: 14512816.
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    140. Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 2003 Jun 02; 21(19-20):2288-97. PMID: 12744859.
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    141. Maguire-Zeiss KA, Federoff HJ. Convergent pathobiologic model of Parkinson's disease. Ann N Y Acad Sci. 2003 Jun; 991:152-66. PMID: 12846984.
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    142. Jarnagin WR, Zager JS, Klimstra D, Delman KA, Malhotra S, Ebright M, Little S, DeRubertis B, Stanziale SF, Hezel M, Federoff H, Fong Y. Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection. Cancer Gene Ther. 2003 Mar; 10(3):215-23. PMID: 12637943.
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    143. Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol Ther. 2003 Feb; 7(2):218-27. PMID: 12597910.
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    144. Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med. 2003 Feb; 9(2):231-5. PMID: 12539041.
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    145. Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Res. 2002 Nov 15; 62(22):6545-51. PMID: 12438249.
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    146. Bennett JJ, Delman KA, Burt BM, Mariotti A, Malhotra S, Zager J, Petrowsky H, Mastorides S, Federoff H, Fong Y. Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer. Cancer Gene Ther. 2002 Nov; 9(11):935-45. PMID: 12386832.
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    147. Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Mol Ther. 2002 Oct; 6(4):455-63. PMID: 12377186.
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    148. Maguire-Zeiss KA, Bowers WJ, Federoff HJ. Somatic mosaic approaches and the aging brain. Neurobiol Aging. 2002 Sep-Oct; 23(5):977-84. PMID: 12392799.
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    149. Bowers WJ, Federoff HJ. Amyloid immunotherapy-engendered CNS inflammation. Neurobiol Aging. 2002 Sep-Oct; 23(5):675-6; discussion 683-4. PMID: 12392770.
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    150. Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep; 236(3):337-42; discussion 342-3. PMID: 12192320; PMCID: PMC1422587.
    151. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12; 297(5579):259-63. PMID: 12114629.
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    152. Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol Ther. 2002 Jul; 6(1):12-8. PMID: 12095298.
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    153. Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Mol Ther. 2002 Jun; 5(6):723-30. PMID: 12027556.
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    154. Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. J Virol. 2002 Jun; 76(11):5565-80. PMID: 11991985; PMCID: PMC137011.
    155. Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002 May; 175(1):35-48. PMID: 12009758.
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    156. Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff HJ, Davidson BL. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6216-21. PMID: 11959904; PMCID: PMC122929.
    157. Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Mol Ther. 2002 Mar; 5(3):300-6. PMID: 11863420.
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    158. Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ. Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplant. 2002; 11(4):331-49. PMID: 12162374.
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    159. Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77. PMID: 11807038.
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    160. Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol Med. 2001 Aug; 7(8):561-8. PMID: 11591892.
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    161. Bennett JJ, Tjuvajev J, Johnson P, Doubrovin M, Akhurst T, Malholtra S, Hackman T, Balatoni J, Finn R, Larson SM, Federoff H, Blasberg R, Fong Y. Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer. Nat Med. 2001 Jul; 7(7):859-63. PMID: 11433353.
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    162. McAuliffe PF, Jarnagin WR, Johnson P, Delman KA, Federoff H, Fong Y. Effective treatment of pancreatic tumors with two multimutated herpes simplex oncolytic viruses. J Gastrointest Surg. 2000 Nov-Dec; 4(6):580-8. PMID: 11307092.
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    163. Jarnagin WR, Delman K, Kooby D, Mastorides S, Zager J, Brennan MF, Blumgart LH, Federoff H, Fong Y. Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. Ann Surg. 2000 May; 231(5):762-71. PMID: 10767798; PMCID: PMC1421064.
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    166. D'Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity. Mol Med. 1999 Sep; 5(9):606-16. PMID: 10551902.
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    167. White SM, Renda M, Nam NY, Klimatcheva E, Zhu Y, Fisk J, Halterman M, Rimel BJ, Federoff H, Pandya S, Rosenblatt JD, Planelles V. Lentivirus vectors using human and simian immunodeficiency virus elements. J Virol. 1999 Apr; 73(4):2832-40. PMID: 10074131; PMCID: PMC104041.
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    169. Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y. Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. Am J Surg. 1998 Nov; 176(5):404-8. PMID: 9874422.
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    170. Staecker H, Gabaizadeh R, Federoff H, Van De Water TR. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg. 1998 Jul; 119(1):7-13. PMID: 9674508.
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    171. Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Am J Pathol. 1998 Jun; 152(6):1521-9. PMID: 9626056; PMCID: PMC1858445.
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    173. Lu B, Gupta S, Federoff H. Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector. Hepatology. 1995 Mar; 21(3):752-9. PMID: 7875674.
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    174. Apfel SC, Arezzo JC, Brownlee M, Federoff H, Kessler JA. Nerve growth factor administration protects against experimental diabetic sensory neuropathy. Brain Res. 1994 Jan 14; 634(1):7-12. PMID: 7512429.
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    175. Grabczyk E, Zuber MX, Federoff HJ, Ng SC, Pack A, Fishman MC. Cloning and Characterization of the Rat Gene Encoding GAP-43. Eur J Neurosci. 1990; 2(10):822-827. PMID: 12106089.
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