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Howard J Federoff

Title(s)Professor, Neurology
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
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    MECHANICAL SYSTEMS RENOVATION
    NIH/NCRR G20RR030966Apr 21, 2010 - Dec 20, 2014
    Role: Principal Investigator
    A Novel Monkey Model for Parkinson's Drug Discovery
    NIH/NINDS RC2NS069450Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Dopamine, mutant synuclein, oxidative stress and inflammation
    NIH/NINDS R01NS057267Sep 15, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Leukocyte-derived Biomarkers as Predictors of Risk and Progression in AD
    NIH/NIA R01AG030753May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Peripheral Macrophage Signatures of Inflammation in Neurodegenerative Diseases
    NIH/NINDS R21NS060213Sep 30, 2007 - Jul 31, 2010
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR023942May 1, 2007 - Mar 31, 2010
    Role: Principal Investigator
    Nectin-1: Synaptic processing and functions
    NIH/NIA R01AG027233Mar 15, 2006 - Jun 30, 2007
    Role: Principal Investigator
    Proteomic Biomarker Discovery in PD
    NIH/NINDS R21NS052151Aug 22, 2005 - May 31, 2007
    Role: Principal Investigator
    Peripheral Leukocyte Biomarkers in Alzheimer's Disease
    NIH/NIA R21AG025354Sep 30, 2004 - Jun 30, 2007
    Role: Principal Investigator
    HSV Amplicon-mediated Disruption of Abeta Fibrillogenesis
    NIH/NIA R01AG020204Sep 30, 2003 - Jul 31, 2007
    Role: Principal Investigator
    Parkinson's Disease Gene Therapy Study Group
    NIH/NINDS U54NS045309Sep 30, 2002 - Aug 31, 2009
    Role: Principal Investigator
    Single-chain Antibody Therapy for Prion Disease
    NIH/NIA R21AG021610Sep 30, 2002 - Aug 31, 2004
    Role: Principal Investigator
    Interdepartmental Neuroscience Training
    NIH/NINDS T32NS007489Sep 30, 2000 - Jun 30, 2015
    Role: Co-Principal Investigator
    ROCHESTER NATHAN SHOCK CENTER
    NIH/NIA P30AG018254Sep 1, 2000 - Jun 30, 2006
    Role: Principal Investigator
    METHODS FOR ANALYSIS OF GENE FUNCTION IN NEURAL NETWORKS
    NIH/NIA R01AG018231Apr 15, 2000 - Mar 31, 2004
    Role: Principal Investigator
    ENVIRONMENTAL NEUROTOXICANT GENETIC ACTION--MURINE MODEL
    NIH/NIEHS R01ES009391May 1, 1998 - Apr 30, 2004
    Role: Principal Investigator
    NEW HSV1 VECTORS FOR LONG TERM GENE EXPRESSION
    NIH/NIDDK R21DK053160Sep 30, 1997 - Aug 31, 2000
    Role: Principal Investigator
    SOMATIC MOSAIC ANALYSIS OF NGF FUNCTION IN MICE
    NIH/NIMH R01MH057047Apr 1, 1997 - Mar 31, 2002
    Role: Principal Investigator
    Improved HSV Vectors: Gene Transfer into Nervous System
    NIH/NINDS R01NS036420Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    GENE THERAPY FOR THE REHABILITATION OF NEUROLOGIC INJURY
    NIH/NICHD R01HD031300Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    MOLECULAR APPROACH TO REGULATION OF SYNAPSE FORMATION
    NIH/NICHD R29HD027116Dec 1, 1989 - Nov 30, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop. J Parkinsons Dis. 2020 Jun 03. Barker RA, Bjorklund A, Gash DM, Whone A, Van Laar A, Kordower JH, Bankiewicz K, Kieburtz K, Saarma M, Booms S, Huttunen HJ, Kells A, Fiandaca MS, Stoessl AJ, Eidelberg D, Federoff H, Voutilainen M, Dexter DT, Eberling J, Brundin P, Isaacs L, Mursaleen L, Bresolin E, Carroll C, Coles A, Fiske B, Matthews H, Lungu C, Wyse RK, Stott S, Lang AE. PMID: 32508331.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep. 2020 Feb 07; 10(1):2484. Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW. PMID: 32034207.
      View in: PubMed   Mentions:    Fields:    
    3. Effect of early-stage Alzheimer's disease on household financial outcomes. Health Econ. 2020 Jan; 29(1):18-29. Gresenz CR, Mitchell JM, Marrone J, Federoff HJ. PMID: 31650668.
      View in: PubMed   Mentions:    Fields:    
    4. PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics. Aging (Albany NY). 2019 09 02; 11(17):6691-6713. Nashine S, Subramaniam SR, Chwa M, Nesburn A, Kuppermann BD, Federoff H, Kenney MC. PMID: 31477635.
      View in: PubMed   Mentions: 1     Fields:    
    5. Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease. Mov Disord. 2019 07; 34(7):1073-1078. Heiss JD, Lungu C, Hammoud DA, Herscovitch P, Ehrlich DJ, Argersinger DP, Sinharay S, Scott G, Wu T, Federoff HJ, Zaghloul KA, Hallett M, Lonser RR, Bankiewicz KS. PMID: 31145831.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media. Int J Mol Sci. 2018 Nov 09; 19(11). Lehrich BM, Liang Y, Khosravi P, Federoff HJ, Fiandaca MS. PMID: 30423996.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Protect NIH's DNA advisory committee. Science. 2018 10 26; 362(6413):409-410. Adelman ZN, Albritton LM, Boris-Lawrie K, Buchmeier MJ, Cannon P, Cho M, DiGiusto D, Donahue JK, Federoff HJ, Hammarskjold ML, Hardison AD, Hearing P, Lee B, Lee DA, Porteus MH, Ross LF, Ross SR, Wooley DP, Zoloth L. PMID: 30361364.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury. Metabolites. 2018 Sep 07; 8(3). Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. PMID: 30205491.
      View in: PubMed   Mentions:
    9. Plasma microRNA markers of upper limb recovery following human stroke. Sci Rep. 2018 08 22; 8(1):12558. Edwardson MA, Zhong X, Fiandaca MS, Federoff HJ, Cheema AK, Dromerick AW. PMID: 30135469.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018; 13(4):e0195318. Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ. PMID: 29677216.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Precision pharmacology for Alzheimer's disease. Pharmacol Res. 2018 04; 130:331-365. Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S. PMID: 29458203.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development. Curr Top Med Chem. 2018; 18(11):883-895. Gross T, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS. PMID: 29992885.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017 Dec 19; 11(1):142. Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki ES, Malik S, Macciardi F, Federoff HJ. PMID: 29258513.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget. 2017 Sep 15; 8(40):68899-68915. Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, Cheema AK. PMID: 28978166.
      View in: PubMed   Mentions: 3     Fields:    
    15. Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype. Int J Geriatr Psychiatry. 2018 02; 33(2):332-339. Chapman BP, Benedict RHB, Lin F, Roy S, Porteinsson A, Szigeti K, Federoff H, Mapstone M. PMID: 28612377.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Front Aging Neurosci. 2017; 9:176. Subramaniam SR, Federoff HJ. PMID: 28642697.
      View in: PubMed   Mentions:
    17. Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models. Mol Ther. 2017 10 04; 25(10):2231-2235. Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff HJ. PMID: 28522034.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Personality and Performance in Specific Neurocognitive Domains Among Older Persons. Am J Geriatr Psychiatry. 2017 Aug; 25(8):900-908. Chapman BP, Benedict RH, Lin F, Roy S, Federoff HJ, Mapstone M. PMID: 28456386.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Biomarker validation: Methods and matrix matter. Alzheimers Dement. 2017 05; 13(5):608-609. Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff HJ. PMID: 28010950.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Mol Ther. 2008 Apr; 16(4):640-646. Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. PMID: 28178462.
      View in: PubMed   Mentions:    Fields:    
    21. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-ß and Interleukin-4. Mol Ther. 2008 May; 16(5):845-853. Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. PMID: 28178487.
      View in: PubMed   Mentions:    Fields:    
    22. What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 03; 51:148-155. Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. PMID: 27939698.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. A genome-wide association study in multiple system atrophy. Neurology. 2016 Oct 11; 87(15):1591-1598. Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff HJ, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H. PMID: 27629089.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    24. Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Front Neurol. 2015; 6:237. Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. PMID: 26617567.
      View in: PubMed   Mentions:
    25. PGC-1a Promoter Methylation in Parkinson's Disease. PLoS One. 2015; 10(8):e0134087. Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff HJ. PMID: 26317511.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    26. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 2015 Oct; 14(10):1002-9. Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB. PMID: 26271532.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    27. Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci. 2015; 9:231. Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff HJ, Newport EL. PMID: 25972803.
      View in: PubMed   Mentions:
    28. Perspectives on best practices for gene therapy programs. Hum Gene Ther. 2015 Mar; 26(3):127-33. Cheever TR, Berkley D, Braun S, Brown RH, Byrne BJ, Chamberlain JS, Cwik V, Duan D, Federoff HJ, High KA, Kaspar BK, Klinger KW, Larkindale J, Lincecum J, Mavilio F, McDonald CL, McLaughlin J, Weiss McLeod B, Mendell JR, Nuckolls G, Stedman HH, Tagle DA, Vandenberghe LH, Wang H, Wernett PJ, Wilson JM, Porter JD, Gubitz AK. PMID: 25654329.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82. Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. PMID: 25473422.
      View in: PubMed   Mentions: 40     Fields:    
    30. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. PMID: 25130657.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    31. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97. O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. PMID: 24773122.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    32. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S196-212. Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. PMID: 24924671.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    33. Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Res Int. 2014; 2014:275178. Su X, Federoff HJ. PMID: 24822191.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    34. The evolution of gene transfer, gene therapy, and the RAC: IOM recommendations to the NIH director. Mol Ther. 2014 Apr; 22(4):685-6. Federoff HJ, Wagner JE. PMID: 24691174.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr; 20(4):415-8. Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. PMID: 24608097.
      View in: PubMed   Mentions: 220     Fields:    Translation:Humans
    36. Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics. 2013 Oct; 10(4):840-51. Huang L, Shimoji M, Wang J, Shah S, Kamila S, Biehl ER, Lim S, Chang A, Maguire-Zeiss KA, Su X, Federoff HJ. PMID: 23963789.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. Int J Mol Sci. 2013 Sep 17; 14(9):19109-27. Huang L, Su X, Federoff HJ. PMID: 24048248.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease. Expert Rev Neurother. 2013 Jun; 13(6):685-93. MacArthur L, Ressom H, Shah S, Federoff HJ. PMID: 23739005.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding? Exp Neurol. 2014 Jun; 256:117-25. Fiandaca MS, Federoff HJ. PMID: 23524194.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    40. Microglial activation and antioxidant responses induced by the Parkinson's disease protein a-synuclein. J Neuroimmune Pharmacol. 2013 Mar; 8(1):94-117. Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA. PMID: 23054368.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    41. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet Neurol. 2012 Jul; 11(7):643-50. Galpern WR, Corrigan-Curay J, Lang AE, Kahn J, Tagle D, Barker RA, Freeman TB, Goetz CG, Kieburtz K, Kim SY, Piantadosi S, Comstock Rick A, Federoff HJ. PMID: 22710757.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    42. Genomics and bioinformatics of Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a009449. Scholz SW, Mhyre T, Ressom H, Shah S, Federoff HJ. PMID: 22762024.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    43. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 2012 Jul 10; 79(2):127-31. Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff HJ, Traynor BJ, Singleton AB, Houlden H. PMID: 22675081.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    44. Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel). 2012 Jun 04; 5(6):553-90. Fiandaca MS, Bankiewicz KS, Federoff HJ. PMID: 24281662.
      View in: PubMed   Mentions:
    45. EDITORIAL: TECHNOLOGY, INNOVATION, AND HEALTH. Technol Innov. 2012 Apr 01; 13(4):261-262. Sanberg PR, Federoff HJ. PMID: 24744821.
      View in: PubMed   Mentions:
    46. TECHNOLOGY AND INVENTION. Technol Innov. 2012; 14(1):1-2. Sanberg PR, Federoff HJ. PMID: 25254084.
      View in: PubMed   Mentions:
    47. Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density. J Neurochem. 2012 Mar; 120(5):741-51. Lim ST, Chang A, Giuliano RE, Federoff HJ. PMID: 22118475.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    48. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 22132130.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    49. Characterization of nectin processing mediated by presenilin-dependent ?-secretase. J Neurochem. 2011 Dec; 119(5):945-56. Kim J, Chang A, Dudak A, Federoff HJ, Lim ST. PMID: 21910732.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. Eur J Neurosci. 2011 Oct; 34(8):1256-67. Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. PMID: 21995852.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    51. Disclosure of clinical trial results when product development is abandoned. Sci Transl Med. 2011 Sep 28; 3(102):102cm29. Rogawski MA, Federoff HJ. PMID: 21957167.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    52. Membrane palmitoylated proteins regulate trafficking and processing of nectins. Eur J Cell Biol. 2011 May; 90(5):365-75. Dudak A, Kim J, Cheong B, Federoff HJ, Lim ST. PMID: 21371776.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    53. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. PMID: 21343917.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    54. Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy. 2011 Feb; 3(2):287-98. Shah S, Federoff HJ. PMID: 21322764.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    55. Technology and innovation: 2010 a year in review. Cell Transplant. 2011; 20(8):1315-9. Sanberg PR, Vindrola-Padros C, Eve DJ, Federoff HJ. PMID: 22080749.
      View in: PubMed   Mentions:    Fields:    
    56. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):852-7. Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. PMID: 21187387.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    57. PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 06; 2(52):52ra73. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR. PMID: 20926834.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansCells
    58. Georgetown University School of Medicine. Acad Med. 2010 Sep; 85(9 Suppl):S131-5. Sistrunk SI, Kumar P, Walther J, Gwinn L, Williams J, Moore ES, Frank I, Weissinger P, Brown LW, Mitchell SR, Federoff HJ. PMID: 20736531.
      View in: PubMed   Mentions:    Fields:    
    59. A new research and development policy framework for the biomedical research enterprise. JAMA. 2010 Sep 01; 304(9):1003-4. Federoff HJ, Rubin ER. PMID: 20810378.
      View in: PubMed   Mentions: 1     Fields:    
    60. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med. 2010 Sep; 16(9):998-1000. Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. PMID: 20729864.
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    61. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 20631185.
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    62. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol Ther. 2010 Aug; 18(8):1471-81. Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. PMID: 20551911.
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    63. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010 Jul; 32(1):10-7. Feng LR, Federoff HJ, Vicini S, Maguire-Zeiss KA. PMID: 20550572.
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    64. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. J Neural Transm (Vienna). 2010 Aug; 117(8):1019-25. Maguire-Zeiss KA, Federoff HJ. PMID: 20549523.
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    65. Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem. 2010 Jul 23; 285(30):22919-26. Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff HJ, Lim ST. PMID: 20501653.
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    66. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J Neurosci Methods. 2010 Jul 15; 190(2):171-9. Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. PMID: 20452375.
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    67. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. J Biol Chem. 2010 Jul 09; 285(28):21329-40. Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. PMID: 20448044.
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    68. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS One. 2010 Feb 02; 5(2):e9002. Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. PMID: 20126313.
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    69. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19671001.
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    70. Death in a gene-therapy trial. N Engl J Med. 2009 Oct 29; 361(18):1811. Zaia JA, Federoff HJ. PMID: 19864684.
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    71. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Ther. 2010 Mar; 17(3):424-31. de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. PMID: 19865178.
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    72. Drug discovery dilemma and Cura quartet collaboration. Drug Discov Today. 2009 Nov; 14(21-22):1006-10. Shah S, Federoff HJ. PMID: 19815089.
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    73. Expression pattern of NuIP gene in adult mouse brain. Brain Res. 2009 Dec 11; 1302:42-53. Luo Y, Sarabi SA, Backman C, Shan L, Hoffer B, Federoff H. PMID: 19765553.
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    74. Evolving from reductionism to holism: is there a future for systems medicine? JAMA. 2009 Sep 02; 302(9):994-6. Federoff HJ, Gostin LO. PMID: 19724047.
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    75. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Mol Ther. 2009 Dec; 17(12):2031-40. Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. PMID: 19638957.
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    76. Development of vaccination approaches for the treatment of neurological diseases. J Comp Neurol. 2009 Jul 01; 515(1):4-14. Federoff HJ. PMID: 19399901.
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    77. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol. 2009 Jun 15; 185(6):1065-81. Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA. PMID: 19528298.
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    78. Immune responses to herpesviral vectors. Hum Gene Ther. 2009 May; 20(5):434-41. Ryan DA, Federoff HJ. PMID: 19216681.
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    79. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Hum Gene Ther. 2009 May; 20(5):442-52. Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. PMID: 19199821.
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    80. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19203243.
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    81. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):511-8. Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19254173.
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    82. Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox Res. 2009 Oct; 16(3):238-54. Su X, Federoff HJ, Maguire-Zeiss KA. PMID: 19526281.
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    83. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotox Res. 2009 Oct; 16(3):261-70. Federoff HJ. PMID: 19526279.
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    84. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. PMID: 19095069.
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    85. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. PMID: 18974297.
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    86. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009 Apr 02; 113(14):3264-75. Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. PMID: 18952891.
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    87. Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases. J Neuroimmune Pharmacol. 2009 Sep; 4(3):298-308. Maguire-Zeiss KA, Federoff HJ. PMID: 18931916.
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    88. A rough morphology of the adsorbed fibronectin layer favors adhesion of neuronal cells. J Biomed Mater Res A. 2008 Oct; 87(1):116-28. Dekeyser CM, Zuyderhoff E, Giuliano RE, Federoff HJ, Dupont-Gillain ChC, Rouxhet PG. PMID: 18085643.
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    89. Identification of a novel nurr1-interacting protein. J Neurosci. 2008 Sep 10; 28(37):9277-86. Luo Y, Xing F, Guiliano R, Federoff HJ. PMID: 18784308.
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    90. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. PMID: 18545225.
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    91. Gene delivery to the nervous system. Mol Ther. 2008 Apr; 16(4):640-6. Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. PMID: 18362921.
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    92. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol Ther. 2008 May; 16(5):845-53. Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. PMID: 18388924.
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    93. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol. 2008 Mar 10; 507(2):1228-44. Lim ST, Lim KC, Giuliano RE, Federoff HJ. PMID: 18181141.
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    94. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. J Neurosci. 2008 Feb 20; 28(8):1988-93. Vangeison G, Carr D, Federoff HJ, Rempe DA. PMID: 18287515.
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    95. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci. 2008 Jun; 38(2):125-37. Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. PMID: 18439838.
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    96. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. J Gene Med. 2008 Feb; 10(2):152-64. Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. PMID: 18058952.
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    97. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6. Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. PMID: 18180775.
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    98. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother. 2008 May; 57(5):663-75. Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. PMID: 17952436.
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    99. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res. 2007 Oct 15; 67(20):10027-37. Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. PMID: 17942937.
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    100. Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Exp Neurol. 2008 Jan; 209(1):101-13. Maguire-Zeiss KA, Mhyre TR, Federoff HJ. PMID: 18035353.
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    101. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 2007 Oct 16; 25(42):7410-21. Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. PMID: 17868958.
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    102. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Mol Ther. 2007 Oct; 15(10):1848-55. Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. PMID: 17653102.
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    103. Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun. 2007 Sep 28; 361(3):599-604. Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ. PMID: 17673176.
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    104. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. J Virol Methods. 2007 Oct; 145(1):37-46. Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. PMID: 17606303.
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    105. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging. 2008 Nov; 29(11):1690-701. Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. PMID: 17537546.
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    106. Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. Neurobiol Aging. 2008 Nov; 29(11):1631-43. Mhyre TR, Loy R, Tariot PN, Profenno LA, Maguire-Zeiss KA, Zhang D, Coleman PD, Federoff HJ. PMID: 17521776.
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    107. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Res. 2007 Aug 08; 1162:98-112. Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD, Pearce DA. PMID: 17617387.
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    108. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem. 2007 Jun 01; 282(22):16187-201. Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff HJ. PMID: 17420250.
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    109. Translational considerations for CNS gene therapy. Expert Opin Biol Ther. 2007 Mar; 7(3):305-18. Ryan DA, Federoff HJ. PMID: 17309323.
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    110. Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Neuron. 2007 Feb 01; 53(3):315-7. Federoff HJ, Mhyre TR. PMID: 17270727.
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    111. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Hum Gene Ther. 2007 Feb; 18(2):93-105. Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. PMID: 17298238.
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    112. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Exp Neurol. 2007 Mar; 204(1):421-32. Miller RM, Kiser GL, Kaysser-Kranich T, Casaceli C, Colla E, Lee MK, Palaniappan C, Federoff HJ. PMID: 17254569.
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    113. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Res. 2007 Feb 23; 1134(1):33-44. Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. PMID: 17196186.
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    114. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 2007 Feb 19; 25(9):1634-46. Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. PMID: 17145123.
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    115. Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiol Aging. 2008 Jan; 29(1):71-7. Miller RM, Federoff HJ. PMID: 17101197.
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    116. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. J Gene Med. 2006 Nov; 8(11):1320-8. Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. PMID: 16989006.
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    117. VIP is a transcriptional target of Nurr1 in dopaminergic cells. Exp Neurol. 2007 Jan; 203(1):221-32. Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff HJ. PMID: 16999955.
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    118. Identification of human alpha-synuclein specific single chain antibodies. Biochem Biophys Res Commun. 2006 Nov 03; 349(4):1198-205. Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff HJ. PMID: 16973126.
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    119. Systems biology: a primer. NeuroRx. 2006 Jul; 3(3):293-4. Federoff HJ, Mhyre TR. PMID: 16815212.
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    120. Microarrays in Parkinson's disease: a systematic approach. NeuroRx. 2006 Jul; 3(3):319-26. Miller RM, Federoff HJ. PMID: 16815215.
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    121. HSV amplicons: neuro applications. Curr Gene Ther. 2006 Jun; 6(3):337-50. Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. PMID: 16787185.
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    122. Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons. Neurobiol Dis. 2006 May; 22(2):284-93. Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff HJ, Cooper JD, Pearce DA. PMID: 16412658.
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    123. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Mol Ther. 2006 Mar; 13(3):580-8. Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. PMID: 16412694.
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    124. CNS gene therapy and a nexus of complexity: systems and biology at a crossroads. Cell Transplant. 2006; 15(3):267-73. Tyler CM, Federoff HJ. PMID: 16719061.
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    125. Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis. 2006 Jan; 44(1):44-9. Rempe D, Vangeison G, Hamilton J, Li Y, Jepson M, Federoff HJ. PMID: 16419044.
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    126. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. Neuroscientist. 2005 Dec; 11(6):539-49. Miller RM, Federoff HJ. PMID: 16282595.
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    127. Immune shaping and the development of Alzheimer's disease vaccines. Sci Aging Knowledge Environ. 2005 Nov 16; 2005(46):pe35. Federoff HJ, Bowers WJ. PMID: 16293586.
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    128. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Exp Neurol. 2006 Feb; 197(2):347-52. Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. PMID: 16289170.
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    129. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Ann Surg Oncol. 2005 Dec; 12(12):1025-36. Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. PMID: 16244806.
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    130. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23. Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. PMID: 16232318.
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    131. Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke. 2005 Oct; 36(10):2232-7. de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff HJ, Stanton PK, Rozental R. PMID: 16179575.
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    132. Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiol Dis. 2006 Feb; 21(2):305-13. Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff HJ. PMID: 16143538.
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    133. Alzheimer's disease: reducing the burden with ApoE2. Gene Ther. 2005 Jul; 12(13):1019-29. Federoff HJ. PMID: 19202630.
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    134. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiol Aging. 2005 May; 26(5):765-75. Miller RM, Chen LL, Kiser GL, Giesler TL, Kaysser-Kranich TM, Palaniappan C, Federoff HJ. PMID: 15708451.
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    135. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiol Aging. 2005 Apr; 26(4):393-407. Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. PMID: 15653168.
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    136. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res. 2005 Mar 24; 134(1):18-23. Maguire-Zeiss KA, Short DW, Federoff HJ. PMID: 15790526.
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    137. beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Res Mol Brain Res. 2005 Feb 18; 133(2):286-98. Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ. PMID: 15710246.
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    138. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. J Virol. 2005 Feb; 79(4):2124-32. Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. PMID: 15681415.
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    139. Novel gene therapeutic strategies for neurodegenerative diseases. Ernst Schering Res Found Workshop. 2005; (53):147-71. Maguire-Zeiss KA, Federoff HJ. PMID: 16315613.
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    140. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci. 2004 Dec 01; 24(48):10963-73. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. PMID: 15574746.
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    141. Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S43-6. Henricksen LA, Federoff HJ. PMID: 15665413.
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    142. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. J Gastrointest Surg. 2004 Nov; 8(7):812-22; discussion 822-3. Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. PMID: 15531234.
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    143. A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004 Oct 12; 63(7):1155-62. Coleman P, Federoff H, Kurlan R. PMID: 15477531.
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    144. Safety of viral vectors for neurological gene therapies. Curr Opin Mol Ther. 2004 Oct; 6(5):473-81. Maguire-Zeiss KA, Federoff HJ. PMID: 15537048.
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    145. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J Neurosci. 2004 Aug 25; 24(34):7445-54. Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff HJ. PMID: 15329391.
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    146. Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases. Ann Surg. 2004 Jun; 239(6):892-9; discussion 899-902. Reinblatt M, Pin RH, Federoff HJ, Fong Y. PMID: 15166969.
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    147. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. J Neurophysiol. 2004 Oct; 92(4):2394-404. Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. PMID: 15152019.
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    148. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest. 2004 Mar; 113(6):876-84. Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ, Ogawa S. PMID: 15067320.
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    149. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004 Feb; 149(1):1-10. Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. PMID: 15104276.
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    150. Neurotrophin secretory pathways and synaptic plasticity. Neurobiol Aging. 2003 Dec; 24(8):1135-45. Lim KC, Lim ST, Federoff HJ. PMID: 14643385.
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    151. Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. Brain Res Mol Brain Res. 2003 Nov 06; 119(1):1-9. Kyrkanides S, Miller JH, Federoff HJ. PMID: 14597224.
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    152. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Mol Ther. 2003 Nov; 8(5):790-5. Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. PMID: 14599812.
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    153. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Exp Neurol. 2003 Sep; 183(1):47-55. Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. PMID: 12957487.
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    154. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. J Neurosci. 2003 Aug 13; 23(19):7385-94. Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. PMID: 12917374.
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    155. Current treatment for Alzheimer disease and future prospects. Alzheimer Dis Assoc Disord. 2003 Jul-Sep; 17 Suppl 4:S105-13. Tariot PN, Federoff HJ. PMID: 14512816.
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    156. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 2003 Jun 02; 21(19-20):2288-97. Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. PMID: 12744859.
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    157. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Ther. 2003 Jun; 10(11):941-5. Bowers WJ, Olschowka JA, Federoff HJ. PMID: 12756414.
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    158. Convergent pathobiologic model of Parkinson's disease. Ann N Y Acad Sci. 2003 Jun; 991:152-66. Maguire-Zeiss KA, Federoff HJ. PMID: 12846984.
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    159. Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection. Cancer Gene Ther. 2003 Mar; 10(3):215-23. Jarnagin WR, Zager JS, Klimstra D, Delman KA, Malhotra S, Ebright M, Little S, DeRubertis B, Stanziale SF, Hezel M, Federoff H, Fong Y. PMID: 12637943.
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    160. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol Ther. 2003 Feb; 7(2):218-27. Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. PMID: 12597910.
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    161. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med. 2003 Feb; 9(2):231-5. Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. PMID: 12539041.
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    162. CNS diseases amenable to gene therapy. Ernst Schering Res Found Workshop. 2003; (43):117-58. Federoff HJ. PMID: 12894455.
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    163. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Res. 2002 Nov 15; 62(22):6545-51. Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. PMID: 12438249.
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    164. Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer. Cancer Gene Ther. 2002 Nov; 9(11):935-45. Bennett JJ, Delman KA, Burt BM, Mariotti A, Malhotra S, Zager J, Petrowsky H, Mastorides S, Federoff H, Fong Y. PMID: 12386832.
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    165. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Mol Ther. 2002 Oct; 6(4):455-63. Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. PMID: 12377186.
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    166. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep; 236(3):337-42; discussion 342-3. Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. PMID: 12192320.
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    167. Amyloid immunotherapy-engendered CNS inflammation. Neurobiol Aging. 2002 Sep-Oct; 23(5):675-6; discussion 683-4. Bowers WJ, Federoff HJ. PMID: 12392770.
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    168. Somatic mosaic approaches and the aging brain. Neurobiol Aging. 2002 Sep-Oct; 23(5):977-84. Maguire-Zeiss KA, Bowers WJ, Federoff HJ. PMID: 12392799.
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    169. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12; 297(5579):259-63. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. PMID: 12114629.
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    170. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol Ther. 2002 Jul; 6(1):12-8. Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. PMID: 12095298.
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    171. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. J Virol. 2002 Jun; 76(11):5565-80. Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. PMID: 11991985.
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    172. Reporter gene transfer induces apoptosis in primary cortical neurons. Mol Ther. 2002 Jun; 5(6):723-30. Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. PMID: 12027556.
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    173. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002 May; 175(1):35-48. Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ. PMID: 12009758.
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    174. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6216-21. Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff HJ, Davidson BL. PMID: 11959904.
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    175. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Mol Ther. 2002 Mar; 5(3):300-6. Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. PMID: 11863420.
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    176. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77. Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. PMID: 11807038.
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    177. Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplant. 2002; 11(4):331-49. Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ. PMID: 12162374.
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    178. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Hum Gene Ther. 2001 Oct 10; 12(15):1867-79. Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. PMID: 11589829.
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    179. Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. Drug Metab Dispos. 2001 Oct; 29(10):1256-62. DeCory HH, Piech-Dumas KM, Sheu SS, Federoff HJ, Anders MW. PMID: 11560867.
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    180. HSV vector-mediated gene delivery to the central nervous system. Curr Opin Mol Ther. 2001 Oct; 3(5):482-90. Maguire-Zeiss KA, Bowers WJ, Federoff HJ. PMID: 11699893.
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    181. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Mol Ther. 2001 Sep; 4(3):250-6. Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y. PMID: 11545616.
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    182. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 2001 Aug 16; 31(3):353-65. Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. PMID: 11516394.
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    183. Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. J Virol. 2001 Aug; 75(15):7050-8. Petrowsky H, Roberts GD, Kooby DA, Burt BM, Bennett JJ, Delman KA, Stanziale SF, Delohery TM, Tong WP, Federoff HJ, Fong Y. PMID: 11435585.
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    184. Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol Med. 2001 Aug; 7(8):561-8. Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. PMID: 11591892.
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    185. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 2001 Jul 15; 98(2):287-95. Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. PMID: 11435295.
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    186. Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer. Nat Med. 2001 Jul; 7(7):859-63. Bennett JJ, Tjuvajev J, Johnson P, Doubrovin M, Akhurst T, Malholtra S, Hackman T, Balatoni J, Finn R, Larson SM, Federoff H, Blasberg R, Fong Y. PMID: 11433353.
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    187. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Mol Ther. 2001 Jun; 3(6):958-63. Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. PMID: 11407910.
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    188. Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model. FASEB J. 2001 May; 15(7):1306-8. Cozzi PJ, Malhotra S, McAuliffe P, Kooby DA, Federoff HJ, Huryk B, Johnson P, Scardino PT, Heston WD, Fong Y. PMID: 11344122.
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    189. Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. Surgery. 2001 Mar; 129(3):324-34. Brooks AD, Ng B, Liu D, Brownlee M, Burt M, Federoff HJ, Fong Y. PMID: 11231461.
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    190. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 2001 Mar 01; 410(6824):89-93. Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. PMID: 11242047.
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    191. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Ther. 2001 Jan; 8(2):111-20. Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. PMID: 11313780.
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    192. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13378-83. Brooks AI, Cory-Slechta DA, Federoff HJ. PMID: 11078505.
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    193. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Hum Gene Ther. 2000 Nov 20; 11(17):2341-52. Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. PMID: 11096439.
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    194. Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory. Neurobiol Learn Mem. 2000 Nov; 74(3):241-58. Brooks AI, Cory-Slechta DA, Murg SL, Federoff HJ. PMID: 11031130.
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    195. Effective treatment of pancreatic tumors with two multimutated herpes simplex oncolytic viruses. J Gastrointest Surg. 2000 Nov-Dec; 4(6):580-8. McAuliffe PF, Jarnagin WR, Johnson P, Delman KA, Federoff H, Fong Y. PMID: 11307092.
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    196. Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro. Neurobiol Dis. 2000 Aug; 7(4):362-74. Telfeian AE, Federoff HJ, Leone P, During MJ, Williamson A. PMID: 10964607.
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    197. Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. Ann Surg. 2000 May; 231(5):762-71. Jarnagin WR, Delman K, Kooby D, Mastorides S, Zager J, Brennan MF, Blumgart LH, Federoff H, Fong Y. PMID: 10767798.
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    198. Efficient cotransduction of tumors by multiple herpes simplex vectors: implications for tumor vaccine production. Cancer Gene Ther. 2000 Apr; 7(4):581-8. Karpoff HM, Kooby D, D'Angelica M, Mack J, Presky DH, Brownlee MD, Federoff H, Fong Y. PMID: 10811476.
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    199. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Mol Ther. 2000 Mar; 1(3):294-9. Bowers WJ, Howard DF, Federoff HJ. PMID: 10933945.
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    200. Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer. J Mol Med (Berl). 2000; 78(3):166-74. Bennett JJ, Kooby DA, Delman K, McAuliffe P, Halterman MW, Federoff H, Fong Y. PMID: 10868479.
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    201. Novel targets for CNS gene therapy. Gene Ther. 1999 Dec; 6(12):1907-8. Federoff HJ. PMID: 10637440.
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    202. Gene therapy in the inner ear. Mechanisms and clinical implications. Ann N Y Acad Sci. 1999 Nov 28; 884:345-60. Van de Water TR, Staecker H, Halterman MW, Federoff HJ. PMID: 10842605.
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    203. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol. 1999 Sep; 159(1):65-72. Halterman MW, Federoff HJ. PMID: 10486175.
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    204. Herpes simplex virus (HSV)-mediated ICAM-1 gene transfer abrogates tumorigenicity and induces anti-tumor immunity. Mol Med. 1999 Sep; 5(9):606-16. D'Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. PMID: 10551902.
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    205. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci. 1999 Aug 15; 19(16):6818-24. Halterman MW, Miller CC, Federoff HJ. PMID: 10436039.
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    206. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). FASEB J. 1999 Aug; 13(11):1325-34. Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y. PMID: 10428757.
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    207. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Hum Gene Ther. 1999 Jul 01; 10(10):1599-606. Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. PMID: 10428205.
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    208. An infectious conspiracy: the case for HSV-1 and APOEepsilon4 in Alzheimer's disease. Neurobiol Aging. 1999 Jul-Aug; 20(4):467-8. Federoff HJ. PMID: 10604442.
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    209. Lentivirus vectors using human and simian immunodeficiency virus elements. J Virol. 1999 Apr; 73(4):2832-40. White SM, Renda M, Nam NY, Klimatcheva E, Zhu Y, Fisk J, Halterman M, Rimel BJ, Federoff H, Pandya S, Rosenblatt JD, Planelles V. PMID: 10074131.
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    210. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res. 1999 Mar 27; 823(1-2):1-10. Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff HJ. PMID: 10095006.
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    211. BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Exp Neurol. 1999 Mar; 156(1):130-7. Antonawich FJ, Federoff HJ, Davis JN. PMID: 10192784.
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    212. G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro. J Gastrointest Surg. 1999 Mar-Apr; 3(2):127-31; discussion 132-3. Lee JH, Federoff HJ, Schoeniger LO. PMID: 10457334.
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    213. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 1999 Feb 05; 10(2):337-44. Brooks AI, Halterman MW, Federoff HJ. PMID: 10203332.
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    214. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 1999 Jan 15; 93(2):643-54. Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. PMID: 9885227.
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    215. In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors. Cancer Immunol Immunother. 1999 Jan; 47(5):265-71. D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y. PMID: 10022470.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    216. Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. Am J Surg. 1998 Nov; 176(5):404-8. Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y. PMID: 9874422.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    217. Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse. J Physiol. 1998 Nov 01; 512 ( Pt 3):779-91. Heath BM, Xia J, Dong E, An RH, Brooks A, Liang C, Federoff HJ, Kass RS. PMID: 9769421.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    218. Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption. J Neurosci Methods. 1998 Sep 01; 83(2):159-64. Deng SX, Panahian N, James H, Gelbard HA, Federoff HJ, Dewhurst S, Epstein LG. PMID: 9765129.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    219. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngol Head Neck Surg. 1998 Jul; 119(1):7-13. Staecker H, Gabaizadeh R, Federoff H, Van De Water TR. PMID: 9674508.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    220. Transduction of human trophoblastic cells by replication-deficient recombinant viral vectors. Promoting cellular differentiation affects virus entry. Am J Pathol. 1998 Jun; 152(6):1521-9. Parry S, Holder J, Halterman MW, Weitzman MD, Davis AR, Federoff H, Strauss JF. PMID: 9626056.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    221. Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. J Neurosci Methods. 1998 Apr 30; 80(2):137-47. Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ. PMID: 9667386.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    222. Towards gene therapy of neurodegenerative disease. Prog Brain Res. 1998; 117:503-10. Federoff HJ, Atkinson M. PMID: 9932428.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    223. Topical application of viral vectors for epidermal gene transfer. J Invest Dermatol. 1997 May; 108(5):803-8. Lu B, Federoff HJ, Wang Y, Goldsmith LA, Scott G. PMID: 9129236.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    224. Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Exp Neurol. 1997 Mar; 144(1):58-68. Bowers WJ, Howard DF, Federoff HJ. PMID: 9126153.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    225. Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon. J Clin Invest. 1997 Feb 15; 99(4):799-804. Karpoff HM, D'Angelica M, Blair S, Brownlee MD, Federoff H, Fong Y. PMID: 9045885.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    226. Somatic gene transfer approaches to manipulate neural networks. J Neurosci Methods. 1997 Jan; 71(1):133-42. Federoff HJ, Brooks A, Muhkerjee B, Corden T. PMID: 9125382.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    227. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nat Biotechnol. 1997 Jan; 15(1):57-62. Brooks AI, Muhkerjee B, Panahian N, Cory-Slechta D, Federoff HJ. PMID: 9035107.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    228. Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production. Hum Gene Ther. 1996 Dec 01; 7(18):2217-24. Tung C, Federoff HJ, Brownlee M, Karpoff H, Weigel T, Brennan MF, Fong Y. PMID: 8953312.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    229. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Hum Gene Ther. 1996 Oct 20; 7(16):2015-24. Jin BK, Belloni M, Conti B, Federoff HJ, Starr R, Son JH, Baker H, Joh TH. PMID: 8930662.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    230. Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum Gene Ther. 1996 Sep 10; 7(14):1719-26. Liu Y, Rabinovitch A, Suarez-Pinzon W, Muhkerjee B, Brownlee M, Edelstein D, Federoff HJ. PMID: 8886842.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    231. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Mol Cell Neurosci. 1996 Mar; 7(3):222-38. Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. PMID: 8726105.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    232. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. Hum Gene Ther. 1996 Jan 20; 7(2):173-82. Geschwind MD, Hartnick CJ, Liu W, Amat J, Van De Water TR, Federoff HJ. PMID: 8788168.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    233. Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors. Hepatology. 1995 Sep; 22(3):723-9. Fong Y, Federoff HJ, Brownlee M, Blumberg D, Blumgart LH, Brennan MF. PMID: 7657275.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    234. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke. 1995 Sep; 26(9):1670-4; discussion 1675. Linnik MD, Zahos P, Geschwind MD, Federoff HJ. PMID: 7544927.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    235. Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med. 1995 Jul; 1(5):527-34. Hammes HP, Federoff HJ, Brownlee M. PMID: 8529118.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    236. Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice. Dev Biol. 1995 Jun; 169(2):533-46. Andrade-Rozental AF, Rozental R, Hassankhani A, Spray DC, Federoff HJ. PMID: 7781897.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    237. A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit. Neurosci Lett. 1995 May 19; 191(1-2):67-70. Casaccia-Bonnefil P, Stelzer A, Federoff HJ, Bergold PJ. PMID: 7659294.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    238. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev Biol. 1995 May; 169(1):309-21. Hassankhani A, Steinhelper ME, Soonpaa MH, Katz EB, Taylor DA, Andrade-Rozental A, Factor SM, Steinberg JJ, Field LJ, Federoff HJ. PMID: 7750647.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    239. Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. Hum Gene Ther. 1995 Apr; 6(4):419-28. Lu B, Federoff HJ. PMID: 7612699.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    240. Ex vivo hepatic gene transfer in mouse using a defective herpes simplex virus-1 vector. Hepatology. 1995 Mar; 21(3):752-9. Lu B, Gupta S, Federoff H. PMID: 7875674.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    241. Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia. Neurosci Lett. 1995 Feb 17; 186(2-3):157-60. Volpe BT, Wessel TC, Mukherjee B, Federoff HJ. PMID: 7777186.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    242. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circ Res. 1995 Feb; 76(2):161-7. Mesri EA, Federoff HJ, Brownlee M. PMID: 7530606.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    243. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Brain Res Mol Brain Res. 1994 Jul; 24(1-4):327-35. Geschwind MD, Kessler JA, Geller AI, Federoff HJ. PMID: 7968372.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    244. Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness. Dev Biol. 1994 May; 163(1):152-61. Xu H, Federoff H, Maragos J, Parada LF, Kessler JA. PMID: 8174770.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    245. Functional characterization of the rat GAP-43 promoter. Brain Res. 1994 Feb 28; 638(1-2):211-20. Starr RG, Lu B, Federoff HJ. PMID: 8199862.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    246. Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):519-23. De Leon JR, Federoff HJ, Dickson DW, Vikstrom KL, Fishman GI. PMID: 8290557.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    247. Nerve growth factor administration protects against experimental diabetic sensory neuropathy. Brain Res. 1994 Jan 14; 634(1):7-12. Apfel SC, Arezzo JC, Brownlee M, Federoff H, Kessler JA. PMID: 7512429.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    248. Stimulation of neurite growth rat adrenal chromaffin cells infected with a defective herpes simplex virus carrying an NGF minigene. Gene Ther. 1994; 1 Suppl 1:S70. Bohn MC, Lin Q, Federoff HJ. PMID: 8542416.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    249. Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices. J Neurosci Methods. 1993 Dec; 50(3):341-51. Casaccia-Bonnefil P, Benedikz E, Shen H, Stelzer A, Edelstein D, Geschwind M, Brownlee M, Federoff HJ, Bergold PJ. PMID: 8152244.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    250. Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain. Brain Res Mol Brain Res. 1993 Oct; 20(1-2):101-10. Lustig RH, Hua P, Wilson MC, Federoff HJ. PMID: 8255171.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    251. Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6165-9. Bergold PJ, Casaccia-Bonnefil P, Zeng XL, Federoff HJ. PMID: 8392189.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    252. Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth. Diabetes. 1993 Apr; 42(4):509-13. Federoff HJ, Lawrence D, Brownlee M. PMID: 8454100.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    253. Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1636-40. Federoff HJ, Geschwind MD, Geller AI, Kessler JA. PMID: 1311846.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    254. Estrogenic regulation and sex dimorphism of growth-associated protein 43 kDa (GAP-43) messenger RNA in the rat. Brain Res Mol Brain Res. 1991 Sep; 11(2):125-32. Lustig RH, Sudol M, Pfaff DW, Federoff HJ. PMID: 1661809.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    255. Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea. J Clin Endocrinol Metab. 1990 Feb; 70(2):311-7. Biller BM, Federoff HJ, Koenig JI, Klibanski A. PMID: 2153693.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    256. Cloning and Characterization of the Rat Gene Encoding GAP-43. Eur J Neurosci. 1990; 2(10):822-827. Grabczyk E, Zuber MX, Federoff HJ, Ng SC, Pack A, Fishman MC. PMID: 12106089.
      View in: PubMed   Mentions: 2     Fields:    
    257. GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system. Brain Res Dev Brain Res. 1989 Apr 01; 46(2):161-8. De la Monte SM, Federoff HJ, Ng SC, Grabczyk E, Fishman MC. PMID: 2720952.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    258. Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids. J Biol Chem. 1988 Dec 25; 263(36):19290-5. Federoff HJ, Grabczyk E, Fishman MC. PMID: 2461937.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    259. Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis. J Bacteriol. 1983 Oct; 156(1):301-7. Federoff HJ, Eccleshall TR, Marmur J. PMID: 6352680.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    260. Regulation of maltase synthesis in Saccharomyces carlsbergensis. J Bacteriol. 1983 Jun; 154(3):1301-8. Federoff HJ, Eccleshall TR, Marmur J. PMID: 6343348.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    261. Isolation of a maltase structural gene from Saccharomyces carlsbergensis. J Bacteriol. 1982 Mar; 149(3):1064-70. Federoff HJ, Cohen JD, Eccleshall TR, Needleman RB, Buchferer BA, Giacalone J, Marmur J. PMID: 7037739.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    262. Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):1078-82. Cohen JD, Eccleshall TR, Needleman RB, Federoff H, Buchferer BA, Marmur J. PMID: 6987664.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    263. Purification and characterization of an alpha-glucosidase from Saccharomyces carlsbergensis. Biochemistry. 1978 Oct 31; 17(22):4657-61. Needleman RB, Federoff HJ, Eccleshall TR, Buchferer B, Marmur J. PMID: 365220.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
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