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Federoff, Howard J

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentNeurology
Address1001 Health Sciences Road
CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    MECHANICAL SYSTEMS RENOVATION
    NIH/NCRR G20RR030966Apr 21, 2010 - Dec 20, 2014
    Role: Principal Investigator
    A Novel Monkey Model for Parkinson's Drug Discovery
    NIH/NINDS RC2NS069450Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Dopamine, mutant synuclein, oxidative stress and inflammation
    NIH/NINDS R01NS057267Sep 15, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Leukocyte-derived Biomarkers as Predictors of Risk and Progression in AD
    NIH/NIA R01AG030753May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Peripheral Macrophage Signatures of Inflammation in Neurodegenerative Diseases
    NIH/NINDS R21NS060213Sep 30, 2007 - Jul 31, 2010
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR023942May 1, 2007 - Jun 30, 2010
    Role: Principal Investigator
    Nectin-1: Synaptic processing and functions
    NIH/NIA R01AG027233Mar 15, 2006 - Jan 31, 2012
    Role: Principal Investigator
    Proteomic Biomarker Discovery in PD
    NIH/NINDS R21NS052151Aug 22, 2005 - Feb 28, 2009
    Role: Principal Investigator
    Peripheral Leukocyte Biomarkers in Alzheimer's Disease
    NIH/NIA R21AG025354Sep 30, 2004 - Jun 30, 2007
    Role: Principal Investigator
    HSV Amplicon-mediated Disruption of Abeta Fibrillogenesis
    NIH/NIA R01AG020204Sep 30, 2003 - Jul 31, 2007
    Role: Principal Investigator
    Parkinson's Disease Gene Therapy Study Group
    NIH/NINDS U54NS045309Sep 30, 2002 - Aug 31, 2009
    Role: Principal Investigator
    Single-chain Antibody Therapy for Prion Disease
    NIH/NIA R21AG021610Sep 30, 2002 - Aug 31, 2004
    Role: Principal Investigator
    Interdepartmental Neuroscience Training
    NIH/NINDS T32NS007489Sep 30, 2000 - Jun 30, 2015
    Role: Co-Principal Investigator
    ROCHESTER NATHAN SHOCK CENTER
    NIH/NIA P30AG018254Sep 1, 2000 - Jun 30, 2006
    Role: Principal Investigator
    METHODS FOR ANALYSIS OF GENE FUNCTION IN NEURAL NETWORKS
    NIH/NIA R01AG018231Apr 15, 2000 - Mar 31, 2004
    Role: Principal Investigator
    ENVIRONMENTAL NEUROTOXICANT GENETIC ACTION--MURINE MODEL
    NIH/NIEHS R01ES009391May 1, 1998 - Apr 30, 2004
    Role: Principal Investigator
    NEW HSV1 VECTORS FOR LONG TERM GENE EXPRESSION
    NIH/NIDDK R21DK053160Sep 30, 1997 - Aug 31, 2000
    Role: Principal Investigator
    Improved HSV Vectors: Gene Transfer into Nervous System
    NIH/NINDS R01NS036420Apr 1, 1997 - Aug 31, 2007
    Role: Principal Investigator
    SOMATIC MOSAIC ANALYSIS OF NGF FUNCTION IN MICE
    NIH/NIMH R01MH057047Apr 1, 1997 - Mar 31, 2002
    Role: Principal Investigator
    GENE THERAPY FOR THE REHABILITATION OF NEUROLOGIC INJURY
    NIH/NICHD R01HD031300Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator
    MOLECULAR APPROACH TO REGULATION OF SYNAPSE FORMATION
    NIH/NICHD R29HD027116Dec 1, 1989 - Nov 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff H. Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018; 13(4):e0195318. PMID: 29677216.
      View in: PubMed
    2. Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff H, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S. Precision pharmacology for Alzheimer's disease. Pharmacol Res. 2018 Apr; 130:331-365. PMID: 29458203.
      View in: PubMed
    3. Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki ES, Malik S, Macciardi F, Federoff H. Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017 Dec 19; 11(1):142. PMID: 29258513.
      View in: PubMed
    4. Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff H, Cheema AK. Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget. 2017 Sep 15; 8(40):68899-68915. PMID: 28978166.
      View in: PubMed
    5. Chapman BP, Benedict RHB, Lin F, Roy S, Porteinsson A, Szigeti K, Federoff H, Mapstone M. Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype. Int J Geriatr Psychiatry. 2018 Feb; 33(2):332-339. PMID: 28612377.
      View in: PubMed
    6. Subramaniam SR, Federoff H. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Front Aging Neurosci. 2017; 9:176. PMID: 28642697.
      View in: PubMed
    7. Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff H. Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models. Mol Ther. 2017 Oct 04; 25(10):2231-2235. PMID: 28522034.
      View in: PubMed
    8. Chapman BP, Benedict RH, Lin F, Roy S, Federoff H, Mapstone M. Personality and Performance in Specific Neurocognitive Domains Among Older Persons. Am J Geriatr Psychiatry. 2017 Aug; 25(8):900-908. PMID: 28456386.
      View in: PubMed
    9. Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff H. Biomarker validation: Methods and matrix matter. Alzheimers Dement. 2017 05; 13(5):608-609. PMID: 28010950.
      View in: PubMed
    10. Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Mol Ther. 2008 Apr; 16(4):640-646. PMID: 28178462.
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    11. Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff H, Bowers WJ. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-ß and Interleukin-4. Mol Ther. 2008 May; 16(5):845-853. PMID: 28178487.
      View in: PubMed
    12. Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff H. What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 Mar; 51:148-155. PMID: 27939698.
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    13. Sailer A, Scholz SW, Nalls MA, Schulte C, Federoff M, Price TR, Lees A, Ross OA, Dickson DW, Mok K, Mencacci NE, Schottlaender L, Chelban V, Ling H, O'Sullivan SS, Wood NW, Traynor BJ, Ferrucci L, Federoff H, Mhyre TR, Morris HR, Deuschl G, Quinn N, Widner H, Albanese A, Infante J, Bhatia KP, Poewe W, Oertel W, Höglinger GU, Wüllner U, Goldwurm S, Pellecchia MT, Ferreira J, Tolosa E, Bloem BR, Rascol O, Meissner WG, Hardy JA, Revesz T, Holton JL, Gasser T, Wenning GK, Singleton AB, Houlden H. A genome-wide association study in multiple system atrophy. Neurology. 2016 Oct 11; 87(15):1591-1598. PMID: 27629089.
      View in: PubMed
    14. Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff H. Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Front Neurol. 2015; 6:237. PMID: 26617567; PMCID: PMC4642213.
    15. Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff H. PGC-1a Promoter Methylation in Parkinson's Disease. PLoS One. 2015; 10(8):e0134087. PMID: 26317511; PMCID: PMC4552803.
    16. Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff H, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 2015 Oct; 14(10):1002-9. PMID: 26271532.
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    17. Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff H, Newport EL. Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci. 2015; 9:231. PMID: 25972803; PMCID: PMC4413691.
    18. Cheever TR, Berkley D, Braun S, Brown RH, Byrne BJ, Chamberlain JS, Cwik V, Duan D, Federoff H, High KA, Kaspar BK, Klinger KW, Larkindale J, Lincecum J, Mavilio F, McDonald CL, McLaughlin J, Weiss McLeod B, Mendell JR, Nuckolls G, Stedman HH, Tagle DA, Vandenberghe LH, Wang H, Wernett PJ, Wilson JM, Porter JD, Gubitz AK. Perspectives on best practices for gene therapy programs. Hum Gene Ther. 2015 Mar; 26(3):127-33. PMID: 25654329; PMCID: PMC4367233.
    19. Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff H, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82. PMID: 25473422.
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    20. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff H, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1. PMID: 25130657.
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    21. Fiandaca MS, Mapstone ME, Cheema AK, Federoff H. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S196-212. PMID: 24924671.
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    22. O'Reilly M, Federoff H, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97. PMID: 24773122; PMCID: PMC4064731.
    23. Su X, Federoff H. Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Res Int. 2014; 2014:275178. PMID: 24822191; PMCID: PMC4005076.
    24. Federoff H, Wagner JE. The evolution of gene transfer, gene therapy, and the RAC: IOM recommendations to the NIH director. Mol Ther. 2014 Apr; 22(4):685-6. PMID: 24691174; PMCID: PMC3982498.
    25. Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff H. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr; 20(4):415-8. PMID: 24608097.
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    26. Huang L, Shimoji M, Wang J, Shah S, Kamila S, Biehl ER, Lim S, Chang A, Maguire-Zeiss KA, Su X, Federoff H. Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics. 2013 Oct; 10(4):840-51. PMID: 23963789; PMCID: PMC3805857.
    27. Huang L, Su X, Federoff H. Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. Int J Mol Sci. 2013 Sep 17; 14(9):19109-27. PMID: 24048248; PMCID: PMC3794823.
    28. MacArthur L, Ressom H, Shah S, Federoff H. Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease. Expert Rev Neurother. 2013 Jun; 13(6):685-93. PMID: 23739005.
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    29. Fiandaca MS, Federoff H. Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding? Exp Neurol. 2014 Jun; 256:117-25. PMID: 23524194.
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    30. Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff H, Shimoji M, Mhyre TR, Maguire-Zeiss KA. Microglial activation and antioxidant responses induced by the Parkinson's disease protein a-synuclein. J Neuroimmune Pharmacol. 2013 Mar; 8(1):94-117. PMID: 23054368; PMCID: PMC3582877.
    31. Galpern WR, Corrigan-Curay J, Lang AE, Kahn J, Tagle D, Barker RA, Freeman TB, Goetz CG, Kieburtz K, Kim SY, Piantadosi S, Comstock Rick A, Federoff H. Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: scientific and ethical considerations. Lancet Neurol. 2012 Jul; 11(7):643-50. PMID: 22710757.
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    32. Scholz SW, Mhyre T, Ressom H, Shah S, Federoff H. Genomics and bioinformatics of Parkinson's disease. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a009449. PMID: 22762024; PMCID: PMC3385936.
    33. Sailer A, Scholz SW, Gibbs JR, Tucci A, Johnson JO, Wood NW, Plagnol V, Hummerich H, Ding J, Hernandez D, Hardy J, Federoff H, Traynor BJ, Singleton AB, Houlden H. Exome sequencing in an SCA14 family demonstrates its utility in diagnosing heterogeneous diseases. Neurology. 2012 Jul 10; 79(2):127-31. PMID: 22675081; PMCID: PMC3390538.
    34. Fiandaca MS, Bankiewicz KS, Federoff H. Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel). 2012 Jun 04; 5(6):553-90. PMID: 24281662; PMCID: PMC3763661.
    35. Sanberg PR, Federoff H. EDITORIAL: TECHNOLOGY, INNOVATION, AND HEALTH. Technol Innov. 2012 Apr 01; 13(4):261-262. PMID: 24744821.
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    36. Sanberg PR, Federoff H. TECHNOLOGY AND INVENTION. Technol Innov. 2012; 14(1):1-2. PMID: 25254084.
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    37. Lim ST, Chang A, Giuliano RE, Federoff H. Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density. J Neurochem. 2012 Mar; 120(5):741-51. PMID: 22118475.
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    38. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff H, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. PMID: 22132130; PMCID: PMC3221672.
    39. Kim J, Chang A, Dudak A, Federoff H, Lim ST. Characterization of nectin processing mediated by presenilin-dependent ?-secretase. J Neurochem. 2011 Dec; 119(5):945-56. PMID: 21910732; PMCID: PMC3217175.
    40. Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff H, Gullo M, Schwab ME, Mendell LM, Arvanian VL. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. Eur J Neurosci. 2011 Oct; 34(8):1256-67. PMID: 21995852; PMCID: PMC3195885.
    41. Rogawski MA, Federoff H. Disclosure of clinical trial results when product development is abandoned. Sci Transl Med. 2011 Sep 28; 3(102):102cm29. PMID: 21957167.
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    42. Dudak A, Kim J, Cheong B, Federoff H, Lim ST. Membrane palmitoylated proteins regulate trafficking and processing of nectins. Eur J Cell Biol. 2011 May; 90(5):365-75. PMID: 21371776; PMCID: PMC3060411.
    43. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff H, Forsayeth JR, Bankiewicz KS. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57. PMID: 21343917; PMCID: PMC3129792.
    44. Shah S, Federoff H. Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy. 2011 Feb; 3(2):287-98. PMID: 21322764.
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    45. Sanberg PR, Vindrola-Padros C, Eve DJ, Federoff H. Technology and innovation: 2010 a year in review. Cell Transplant. 2011; 20(8):1315-9. PMID: 22080749.
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    46. Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff H, Halegoua S. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):852-7. PMID: 21187387; PMCID: PMC3021064.
    47. Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff H, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR. PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med. 2010 Oct 06; 2(52):52ra73. PMID: 20926834; PMCID: PMC3129986.
    48. Sistrunk SI, Kumar P, Walther J, Gwinn L, Williams J, Moore ES, Frank I, Weissinger P, Brown LW, Mitchell SR, Federoff H. Georgetown University School of Medicine. Acad Med. 2010 Sep; 85(9 Suppl):S131-5. PMID: 20736531.
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    49. Federoff H, Rubin ER. A new research and development policy framework for the biomedical research enterprise. JAMA. 2010 Sep 01; 304(9):1003-4. PMID: 20810378.
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    50. Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff H, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nat Med. 2010 Sep; 16(9):998-1000. PMID: 20729864.
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    51. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff H, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. PMID: 20631185; PMCID: PMC2914692.
    52. Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff H, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol Ther. 2010 Aug; 18(8):1471-81. PMID: 20551911; PMCID: PMC2927061.
    53. Feng LR, Federoff H, Vicini S, Maguire-Zeiss KA. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010 Jul; 32(1):10-7. PMID: 20550572; PMCID: PMC2900531.
    54. Maguire-Zeiss KA, Federoff H. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. J Neural Transm (Vienna). 2010 Aug; 117(8):1019-25. PMID: 20549523.
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    55. Kim J, Lilliehook C, Dudak A, Prox J, Saftig P, Federoff H, Lim ST. Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10). J Biol Chem. 2010 Jul 23; 285(30):22919-26. PMID: 20501653; PMCID: PMC2906284.
    56. Ryan DA, Narrow WC, Federoff H, Bowers WJ. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. J Neurosci Methods. 2010 Jul 15; 190(2):171-9. PMID: 20452375; PMCID: PMC2902796.
    57. Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff H. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. J Biol Chem. 2010 Jul 09; 285(28):21329-40. PMID: 20448044; PMCID: PMC2898390.
    58. Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLoS One. 2010 Feb 02; 5(2):e9002. PMID: 20126313; PMCID: PMC2814869.
    59. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff H, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. PMID: 19671001; PMCID: PMC2861959.
    60. Zaia JA, Federoff H. Death in a gene-therapy trial. N Engl J Med. 2009 Oct 29; 361(18):1811. PMID: 19864684.
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    61. de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff H, Bowers WJ. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Ther. 2010 Mar; 17(3):424-31. PMID: 19865178; PMCID: PMC2837128.
    62. Shah S, Federoff H. Drug discovery dilemma and Cura quartet collaboration. Drug Discov Today. 2009 Nov; 14(21-22):1006-10. PMID: 19815089.
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    63. Luo Y, Sarabi SA, Backman C, Shan L, Hoffer B, Federoff H. Expression pattern of NuIP gene in adult mouse brain. Brain Res. 2009 Dec 11; 1302:42-53. PMID: 19765553.
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    64. Federoff H, Gostin LO. Evolving from reductionism to holism: is there a future for systems medicine? JAMA. 2009 Sep 02; 302(9):994-6. PMID: 19724047.
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    65. Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff H, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Mol Ther. 2009 Dec; 17(12):2031-40. PMID: 19638957; PMCID: PMC2788047.
    66. Federoff H. Development of vaccination approaches for the treatment of neurological diseases. J Comp Neurol. 2009 Jul 01; 515(1):4-14. PMID: 19399901.
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    67. Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff H, Rempe DA. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol. 2009 Jun 15; 185(6):1065-81. PMID: 19528298; PMCID: PMC2711615.
    68. Ryan DA, Federoff H. Immune responses to herpesviral vectors. Hum Gene Ther. 2009 May; 20(5):434-41. PMID: 19216681; PMCID: PMC2828622.
    69. Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff H. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Hum Gene Ther. 2009 May; 20(5):442-52. PMID: 19199821; PMCID: PMC2828628.
    70. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff H, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. PMID: 19203243; PMCID: PMC2767387.
    71. Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff H, Forsayeth J, Bankiewicz KS. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):511-8. PMID: 19254173; PMCID: PMC2725183.
    72. Su X, Federoff H, Maguire-Zeiss KA. Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox Res. 2009 Oct; 16(3):238-54. PMID: 19526281; PMCID: PMC2877375.
    73. Federoff H. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotox Res. 2009 Oct; 16(3):261-70. PMID: 19526279.
      View in: PubMed
    74. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
    75. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff H, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol. 2008 Dec; 173(6):1768-82. PMID: 18974297; PMCID: PMC2626388.
    76. Daubeuf S, Singh D, Tan Y, Liu H, Federoff H, Bowers WJ, Tolba K. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009 Apr 02; 113(14):3264-75. PMID: 18952891; PMCID: PMC3401030.
    77. Maguire-Zeiss KA, Federoff H. Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases. J Neuroimmune Pharmacol. 2009 Sep; 4(3):298-308. PMID: 18931916; PMCID: PMC2879638.
    78. Dekeyser CM, Zuyderhoff E, Giuliano RE, Federoff H, Dupont-Gillain ChC, Rouxhet PG. A rough morphology of the adsorbed fibronectin layer favors adhesion of neuronal cells. J Biomed Mater Res A. 2008 Oct; 87(1):116-28. PMID: 18085643.
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    79. Luo Y, Xing F, Guiliano R, Federoff H. Identification of a novel nurr1-interacting protein. J Neurosci. 2008 Sep 10; 28(37):9277-86. PMID: 18784308.
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    80. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff H, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. PMID: 18545225; PMCID: PMC2725180.
    81. Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene delivery to the nervous system. Mol Ther. 2008 Apr; 16(4):640-6. PMID: 18362921; PMCID: PMC2630580.
    82. Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff H, Bowers WJ. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol Ther. 2008 May; 16(5):845-53. PMID: 18388924; PMCID: PMC2441486.
    83. Lim ST, Lim KC, Giuliano RE, Federoff H. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol. 2008 Mar 10; 507(2):1228-44. PMID: 18181141.
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    84. Vangeison G, Carr D, Federoff H, Rempe DA. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. J Neurosci. 2008 Feb 20; 28(8):1988-93. PMID: 18287515.
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    85. Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff H. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Mol Cell Neurosci. 2008 Jun; 38(2):125-37. PMID: 18439838; PMCID: PMC2652244.
    86. Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff H, Bowers WJ. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. J Gene Med. 2008 Feb; 10(2):152-64. PMID: 18058952; PMCID: PMC2440655.
    87. Wuertzer CA, Sullivan MA, Qiu X, Federoff H. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6. PMID: 18180775.
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    88. Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff H, Bowers WJ, Tolba KA, Rosenblatt JD. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunol Immunother. 2008 May; 57(5):663-75. PMID: 17952436.
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    89. Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff H, Tolba KA, Rosenblatt JD. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Res. 2007 Oct 15; 67(20):10027-37. PMID: 17942937.
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    90. Maguire-Zeiss KA, Mhyre TR, Federoff H. Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Exp Neurol. 2008 Jan; 209(1):101-13. PMID: 18035353.
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    91. Duke CM, Maguire CA, Keefer MC, Federoff H, Bowers WJ, Dewhurst S. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 2007 Oct 16; 25(42):7410-21. PMID: 17868958; PMCID: PMC2092414.
    92. Peterson EB, Mastrangelo MA, Federoff H, Bowers WJ. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Mol Ther. 2007 Oct; 15(10):1848-55. PMID: 17653102; PMCID: PMC2587304.
    93. Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff H. Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun. 2007 Sep 28; 361(3):599-604. PMID: 17673176.
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    94. Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff H, Bowers WJ, Dewhurst S. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. J Virol Methods. 2007 Oct; 145(1):37-46. PMID: 17606303; PMCID: PMC2080840.
    95. Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff H. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging. 2008 Nov; 29(11):1690-701. PMID: 17537546; PMCID: PMC2621109.
    96. Mhyre TR, Loy R, Tariot PN, Profenno LA, Maguire-Zeiss KA, Zhang D, Coleman PD, Federoff H. Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium. Neurobiol Aging. 2008 Nov; 29(11):1631-43. PMID: 17521776; PMCID: PMC2621111.
    97. Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff H, Cooper JD, Pearce DA. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Res. 2007 Aug 08; 1162:98-112. PMID: 17617387; PMCID: PMC4790084.
    98. Rempe DA, Lelli KM, Vangeison G, Johnson RS, Federoff H. In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage. J Biol Chem. 2007 Jun 01; 282(22):16187-201. PMID: 17420250.
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    99. Ryan DA, Federoff H. Translational considerations for CNS gene therapy. Expert Opin Biol Ther. 2007 Mar; 7(3):305-18. PMID: 17309323.
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    100. Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff H, Dewhurst S, Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Hum Gene Ther. 2007 Feb; 18(2):93-105. PMID: 17298238.
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    101. Federoff H, Mhyre TR. Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Neuron. 2007 Feb 01; 53(3):315-7. PMID: 17270727.
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    102. Miller RM, Kiser GL, Kaysser-Kranich T, Casaceli C, Colla E, Lee MK, Palaniappan C, Federoff H. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Exp Neurol. 2007 Mar; 204(1):421-32. PMID: 17254569.
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    103. Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff H, Collier TJ. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Res. 2007 Feb 23; 1134(1):33-44. PMID: 17196186; PMCID: PMC2041451.
    104. Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff H, Frelinger JG, Bowers WJ, Dewhurst S. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 2007 Feb 19; 25(9):1634-46. PMID: 17145123; PMCID: PMC1851942.
    105. Miller RM, Federoff H. Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiol Aging. 2008 Jan; 29(1):71-7. PMID: 17101197.
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    106. Halterman MW, Giuliano RE, Bowers WJ, Federoff H. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. J Gene Med. 2006 Nov; 8(11):1320-8. PMID: 16989006.
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    107. Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff H. VIP is a transcriptional target of Nurr1 in dopaminergic cells. Exp Neurol. 2007 Jan; 203(1):221-32. PMID: 16999955.
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    108. Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff H. Identification of human alpha-synuclein specific single chain antibodies. Biochem Biophys Res Commun. 2006 Nov 03; 349(4):1198-205. PMID: 16973126.
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    109. Miller RM, Federoff H. Microarrays in Parkinson's disease: a systematic approach. NeuroRx. 2006 Jul; 3(3):319-26. PMID: 16815215; PMCID: PMC3593377.
    110. Federoff H, Mhyre TR. Systems biology: a primer. NeuroRx. 2006 Jul; 3(3):293-4. PMID: 16815212; PMCID: PMC3593376.
    111. Tyler CM, Wuertzer CA, Bowers WJ, Federoff H. HSV amplicons: neuro applications. Curr Gene Ther. 2006 Jun; 6(3):337-50. PMID: 16787185.
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    112. Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff H. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Mol Ther. 2006 Mar; 13(3):580-8. PMID: 16412694.
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    113. Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff H, Cooper JD, Pearce DA. Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons. Neurobiol Dis. 2006 May; 22(2):284-93. PMID: 16412658; PMCID: PMC3651998.
    114. Tyler CM, Federoff H. CNS gene therapy and a nexus of complexity: systems and biology at a crossroads. Cell Transplant. 2006; 15(3):267-73. PMID: 16719061.
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    115. Rempe D, Vangeison G, Hamilton J, Li Y, Jepson M, Federoff H. Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis. 2006 Jan; 44(1):44-9. PMID: 16419044.
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    116. Miller RM, Federoff H. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. Neuroscientist. 2005 Dec; 11(6):539-49. PMID: 16282595.
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    117. Federoff H, Bowers WJ. Immune shaping and the development of Alzheimer's disease vaccines. Sci Aging Knowledge Environ. 2005 Nov 16; 2005(46):pe35. PMID: 16293586; PMCID: PMC2447918.
    118. Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff H, Mendell LM. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Exp Neurol. 2006 Feb; 197(2):347-52. PMID: 16289170.
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    119. Reinblatt M, Pin RH, Bowers WJ, Federoff H, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Ann Surg Oncol. 2005 Dec; 12(12):1025-36. PMID: 16244806.
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    120. Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff H, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation. 2005 Oct 18; 2:23. PMID: 16232318; PMCID: PMC1276812.
    121. de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, Spray DC, Federoff H, Stanton PK, Rozental R. Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke. 2005 Oct; 36(10):2232-7. PMID: 16179575.
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    122. Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff H. Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiol Dis. 2006 Feb; 21(2):305-13. PMID: 16143538.
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    123. Federoff H. Alzheimer's disease: reducing the burden with ApoE2. Gene Ther. 2005 Jul; 12(13):1019-29. PMID: 19202630.
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    124. Miller RM, Chen LL, Kiser GL, Giesler TL, Kaysser-Kranich TM, Palaniappan C, Federoff H. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiol Aging. 2005 May; 26(5):765-75. PMID: 15708451.
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    125. Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff H. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiol Aging. 2005 Apr; 26(4):393-407. PMID: 15653168.
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    126. Maguire-Zeiss KA, Short DW, Federoff H. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res. 2005 Mar 24; 134(1):18-23. PMID: 15790526.
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    127. Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff H. beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Res Mol Brain Res. 2005 Feb 18; 133(2):286-98. PMID: 15710246.
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    128. Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff H, Gendelman HE, Poluektova L. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. J Virol. 2005 Feb; 79(4):2124-32. PMID: 15681415; PMCID: PMC546587.
    129. Maguire-Zeiss KA, Federoff H. Novel gene therapeutic strategies for neurodegenerative diseases. Ernst Schering Res Found Workshop. 2005; (53):147-71. PMID: 16315613.
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    130. Henricksen LA, Federoff H. Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S43-6. PMID: 15665413.
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    131. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff H, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. J Neurosci. 2004 Dec 01; 24(48):10963-73. PMID: 15574746.
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    132. Pin RH, Reinblatt M, Bowers WJ, Federoff H, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. J Gastrointest Surg. 2004 Nov; 8(7):812-22; discussion 822-3. PMID: 15531234.
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    133. Coleman P, Federoff H, Kurlan R. A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004 Oct 12; 63(7):1155-62. PMID: 15477531.
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    134. Maguire-Zeiss KA, Federoff H. Safety of viral vectors for neurological gene therapies. Curr Opin Mol Ther. 2004 Oct; 6(5):473-81. PMID: 15537048.
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    135. Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff H. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. J Neurosci. 2004 Aug 25; 24(34):7445-54. PMID: 15329391.
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    136. Reinblatt M, Pin RH, Federoff H, Fong Y. Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases. Ann Surg. 2004 Jun; 239(6):892-9; discussion 899-902. PMID: 15166969; PMCID: PMC1356298.
    137. Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff H, Mendell LM. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. J Neurophysiol. 2004 Oct; 92(4):2394-404. PMID: 15152019.
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    138. Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff H, Ogawa S. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest. 2004 Mar; 113(6):876-84. PMID: 15067320; PMCID: PMC362115.
    139. Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff H, Rosenblatt JP, Wang N. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genet Cytogenet. 2004 Feb; 149(1):1-10. PMID: 15104276.
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    140. Lim KC, Lim ST, Federoff H. Neurotrophin secretory pathways and synaptic plasticity. Neurobiol Aging. 2003 Dec; 24(8):1135-45. PMID: 14643385.
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    141. Kyrkanides S, Miller JH, Federoff H. Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. Brain Res Mol Brain Res. 2003 Nov 06; 119(1):1-9. PMID: 14597224.
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    142. Kyrkanides S, Miller Jn, Bowers WJ, Federoff H. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Mol Ther. 2003 Nov; 8(5):790-5. PMID: 14599812.
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    143. Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff H. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Exp Neurol. 2003 Sep; 183(1):47-55. PMID: 12957487.
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    144. Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff H, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. J Neurosci. 2003 Aug 13; 23(19):7385-94. PMID: 12917374.
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    145. Tariot PN, Federoff H. Current treatment for Alzheimer disease and future prospects. Alzheimer Dis Assoc Disord. 2003 Jul-Sep; 17 Suppl 4:S105-13. PMID: 14512816.
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    146. Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff H, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 2003 Jun 02; 21(19-20):2288-97. PMID: 12744859.
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    147. Bowers WJ, Olschowka JA, Federoff H. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Ther. 2003 Jun; 10(11):941-5. PMID: 12756414.
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    148. Maguire-Zeiss KA, Federoff H. Convergent pathobiologic model of Parkinson's disease. Ann N Y Acad Sci. 2003 Jun; 991:152-66. PMID: 12846984.
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    149. Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff H. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol Ther. 2003 Feb; 7(2):218-27. PMID: 12597910.
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    150. Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff H, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nat Med. 2003 Feb; 9(2):231-5. PMID: 12539041.
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    151. Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff H, Rosenblatt JD. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Res. 2002 Nov 15; 62(22):6545-51. PMID: 12438249.
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    152. Bennett JJ, Delman KA, Burt BM, Mariotti A, Malhotra S, Zager J, Petrowsky H, Mastorides S, Federoff H, Fong Y. Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer. Cancer Gene Ther. 2002 Nov; 9(11):935-45. PMID: 12386832.
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    153. Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff H, Rosenblatt JD. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Mol Ther. 2002 Oct; 6(4):455-63. PMID: 12377186.
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    154. Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff H, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep; 236(3):337-42; discussion 342-3. PMID: 12192320; PMCID: PMC1422587.
    155. Maguire-Zeiss KA, Bowers WJ, Federoff H. Somatic mosaic approaches and the aging brain. Neurobiol Aging. 2002 Sep-Oct; 23(5):977-84. PMID: 12392799.
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    156. Bowers WJ, Federoff H. Amyloid immunotherapy-engendered CNS inflammation. Neurobiol Aging. 2002 Sep-Oct; 23(5):675-6; discussion 683-4. PMID: 12392770.
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    157. Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff H, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12; 297(5579):259-63. PMID: 12114629.
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    158. Bowers WJ, Chen X, Guo H, Frisina DR, Federoff H, Frisina RD. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Mol Ther. 2002 Jul; 6(1):12-8. PMID: 12095298.
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    159. Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff H, Dewhurst S. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. J Virol. 2002 Jun; 76(11):5565-80. PMID: 11991985; PMCID: PMC137011.
    160. Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff H, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Mol Ther. 2002 Jun; 5(6):723-30. PMID: 12027556.
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    161. Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff H. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002 May; 175(1):35-48. PMID: 12009758.
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    162. Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff H, Davidson BL. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6216-21. PMID: 11959904; PMCID: PMC122929.
    163. Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff H, Bowers WJ. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Mol Ther. 2002 Mar; 5(3):300-6. PMID: 11863420.
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    164. Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff H, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77. PMID: 11807038.
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    165. Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff H, Sonstein WJ. Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplant. 2002; 11(4):331-49. PMID: 12162374.
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    166. Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff H, Lord EM, Frelinger JG. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Hum Gene Ther. 2001 Oct 10; 12(15):1867-79. PMID: 11589829.
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    167. Maguire-Zeiss KA, Bowers WJ, Federoff H. HSV vector-mediated gene delivery to the central nervous system. Curr Opin Mol Ther. 2001 Oct; 3(5):482-90. PMID: 11699893.
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    168. DeCory HH, Piech-Dumas KM, Sheu SS, Federoff H, Anders MW. Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. Drug Metab Dispos. 2001 Oct; 29(10):1256-62. PMID: 11560867.
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    169. Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff H, Fong Y. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Mol Ther. 2001 Sep; 4(3):250-6. PMID: 11545616.
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    170. Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff H, Rose DW, Rosenfeld MG, Brehm P, Mandel G. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 2001 Aug 16; 31(3):353-65. PMID: 11516394.
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    171. Petrowsky H, Roberts GD, Kooby DA, Burt BM, Bennett JJ, Delman KA, Stanziale SF, Delohery TM, Tong WP, Federoff H, Fong Y. Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. J Virol. 2001 Aug; 75(15):7050-8. PMID: 11435585; PMCID: PMC114433.
    172. Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff H, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 2001 Jul 15; 98(2):287-95. PMID: 11435295.
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    173. Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff H. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Mol Ther. 2001 Jun; 3(6):958-63. PMID: 11407910.
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    174. Cozzi PJ, Malhotra S, McAuliffe P, Kooby DA, Federoff H, Huryk B, Johnson P, Scardino PT, Heston WD, Fong Y. Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model. FASEB J. 2001 May; 15(7):1306-8. PMID: 11344122.
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    175. Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff H, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 2001 Mar 01; 410(6824):89-93. PMID: 11242047.
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    176. Brooks AD, Ng B, Liu D, Brownlee M, Burt M, Federoff H, Fong Y. Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. Surgery. 2001 Mar; 129(3):324-34. PMID: 11231461.
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    177. Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff H. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Ther. 2001 Jan; 8(2):111-20. PMID: 11313780.
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    178. Brooks AI, Cory-Slechta DA, Federoff H. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13378-83. PMID: 11078505; PMCID: PMC27232.
    179. Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff H. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Hum Gene Ther. 2000 Nov 20; 11(17):2341-52. PMID: 11096439.
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    180. Brooks AI, Cory-Slechta DA, Murg SL, Federoff H. Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory. Neurobiol Learn Mem. 2000 Nov; 74(3):241-58. PMID: 11031130.
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    181. Telfeian AE, Federoff H, Leone P, During MJ, Williamson A. Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro. Neurobiol Dis. 2000 Aug; 7(4):362-74. PMID: 10964607.
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    182. Bowers WJ, Howard DF, Federoff H. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Mol Ther. 2000 Mar; 1(3):294-9. PMID: 10933945.
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    183. Federoff H. Novel targets for CNS gene therapy. Gene Ther. 1999 Dec; 6(12):1907-8. PMID: 10637440.
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    184. Van de Water TR, Staecker H, Halterman MW, Federoff H. Gene therapy in the inner ear. Mechanisms and clinical implications. Ann N Y Acad Sci. 1999 Nov 28; 884:345-60. PMID: 10842605.
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    185. Halterman MW, Federoff H. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Exp Neurol. 1999 Sep; 159(1):65-72. PMID: 10486175.
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    186. Halterman MW, Miller CC, Federoff H. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci. 1999 Aug 15; 19(16):6818-24. PMID: 10436039.
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    187. Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff H, Fong Y. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). FASEB J. 1999 Aug; 13(11):1325-34. PMID: 10428757.
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    188. Carew JF, Kooby DA, Halterman MW, Federoff H, Fong Y. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Hum Gene Ther. 1999 Jul 01; 10(10):1599-606. PMID: 10428205.
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    189. Federoff H. An infectious conspiracy: the case for HSV-1 and APOEepsilon4 in Alzheimer's disease. Neurobiol Aging. 1999 Jul-Aug; 20(4):467-8. PMID: 10604442.
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    190. Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff H. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res. 1999 Mar 27; 823(1-2):1-10. PMID: 10095006.
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    191. Antonawich FJ, Federoff H, Davis JN. BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Exp Neurol. 1999 Mar; 156(1):130-7. PMID: 10192784.
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    192. Lee JH, Federoff H, Schoeniger LO. G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro. J Gastrointest Surg. 1999 Mar-Apr; 3(2):127-31; discussion 132-3. PMID: 10457334.
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    193. Brooks AI, Halterman MW, Federoff H. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 1999 Feb 05; 10(2):337-44. PMID: 10203332.
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    194. Kutubuddin M, Federoff H, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 1999 Jan 15; 93(2):643-54. PMID: 9885227.
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    195. Heath BM, Xia J, Dong E, An RH, Brooks A, Liang C, Federoff H, Kass RS. Overexpression of nerve growth factor in the heart alters ion channel activity and beta-adrenergic signalling in an adult transgenic mouse. J Physiol. 1998 Nov 01; 512 ( Pt 3):779-91. PMID: 9769421; PMCID: PMC2231244.
    196. Deng SX, Panahian N, James H, Gelbard HA, Federoff H, Dewhurst S, Epstein LG. Luciferase: a sensitive and quantitative probe for blood-brain barrier disruption. J Neurosci Methods. 1998 Sep 01; 83(2):159-64. PMID: 9765129.
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    197. Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff H. Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. J Neurosci Methods. 1998 Apr 30; 80(2):137-47. PMID: 9667386.
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    198. Federoff H, Atkinson M. Towards gene therapy of neurodegenerative disease. Prog Brain Res. 1998; 117:503-10. PMID: 9932428.
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    199. Lu B, Federoff H, Wang Y, Goldsmith LA, Scott G. Topical application of viral vectors for epidermal gene transfer. J Invest Dermatol. 1997 May; 108(5):803-8. PMID: 9129236.
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    200. Bowers WJ, Howard DF, Federoff H. Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Exp Neurol. 1997 Mar; 144(1):58-68. PMID: 9126153.
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    201. Brooks AI, Muhkerjee B, Panahian N, Cory-Slechta D, Federoff H. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nat Biotechnol. 1997 Jan; 15(1):57-62. PMID: 9035107.
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    202. Federoff H, Brooks A, Muhkerjee B, Corden T. Somatic gene transfer approaches to manipulate neural networks. J Neurosci Methods. 1997 Jan; 71(1):133-42. PMID: 9125382.
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    203. Tung C, Federoff H, Brownlee M, Karpoff H, Weigel T, Brennan MF, Fong Y. Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production. Hum Gene Ther. 1996 Dec 01; 7(18):2217-24. PMID: 8953312.
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    204. Jin BK, Belloni M, Conti B, Federoff H, Starr R, Son JH, Baker H, Joh TH. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Hum Gene Ther. 1996 Oct 20; 7(16):2015-24. PMID: 8930662.
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    205. Liu Y, Rabinovitch A, Suarez-Pinzon W, Muhkerjee B, Brownlee M, Edelstein D, Federoff H. Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum Gene Ther. 1996 Sep 10; 7(14):1719-26. PMID: 8886842.
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    206. Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff H, Geller AI, Hefti F. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Mol Cell Neurosci. 1996 Mar; 7(3):222-38. PMID: 8726105.
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    207. Geschwind MD, Hartnick CJ, Liu W, Amat J, Van De Water TR, Federoff H. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. Hum Gene Ther. 1996 Jan 20; 7(2):173-82. PMID: 8788168.
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    208. Fong Y, Federoff H, Brownlee M, Blumberg D, Blumgart LH, Brennan MF. Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors. Hepatology. 1995 Sep; 22(3):723-9. PMID: 7657275.
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    209. Linnik MD, Zahos P, Geschwind MD, Federoff H. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke. 1995 Sep; 26(9):1670-4; discussion 1675. PMID: 7544927.
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    210. Hammes HP, Federoff H, Brownlee M. Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med. 1995 Jul; 1(5):527-34. PMID: 8529118; PMCID: PMC2229962.
    211. Andrade-Rozental AF, Rozental R, Hassankhani A, Spray DC, Federoff H. Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice. Dev Biol. 1995 Jun; 169(2):533-46. PMID: 7781897.
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    212. Casaccia-Bonnefil P, Stelzer A, Federoff H, Bergold PJ. A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit. Neurosci Lett. 1995 May 19; 191(1-2):67-70. PMID: 7659294.
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    213. Hassankhani A, Steinhelper ME, Soonpaa MH, Katz EB, Taylor DA, Andrade-Rozental A, Factor SM, Steinberg JJ, Field LJ, Federoff H. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev Biol. 1995 May; 169(1):309-21. PMID: 7750647.
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    214. Lu B, Federoff H. Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. Hum Gene Ther. 1995 Apr; 6(4):419-28. PMID: 7612699.
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    215. Volpe BT, Wessel TC, Mukherjee B, Federoff H. Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia. Neurosci Lett. 1995 Feb 17; 186(2-3):157-60. PMID: 7777186.
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    216. Mesri EA, Federoff H, Brownlee M. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circ Res. 1995 Feb; 76(2):161-7. PMID: 7530606.
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    217. Geschwind MD, Kessler JA, Geller AI, Federoff H. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Brain Res Mol Brain Res. 1994 Jul; 24(1-4):327-35. PMID: 7968372.
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    218. Starr RG, Lu B, Federoff H. Functional characterization of the rat GAP-43 promoter. Brain Res. 1994 Feb 28; 638(1-2):211-20. PMID: 8199862.
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    219. De Leon JR, Federoff H, Dickson DW, Vikstrom KL, Fishman GI. Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):519-23. PMID: 8290557; PMCID: PMC42980.
    220. Bohn MC, Lin Q, Federoff H. Stimulation of neurite growth rat adrenal chromaffin cells infected with a defective herpes simplex virus carrying an NGF minigene. Gene Ther. 1994; 1 Suppl 1:S70. PMID: 8542416.
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    221. Casaccia-Bonnefil P, Benedikz E, Shen H, Stelzer A, Edelstein D, Geschwind M, Brownlee M, Federoff H, Bergold PJ. Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices. J Neurosci Methods. 1993 Dec; 50(3):341-51. PMID: 8152244.
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    222. Lustig RH, Hua P, Wilson MC, Federoff H. Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain. Brain Res Mol Brain Res. 1993 Oct; 20(1-2):101-10. PMID: 8255171.
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    223. Bergold PJ, Casaccia-Bonnefil P, Zeng XL, Federoff H. Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6165-9. PMID: 8392189; PMCID: PMC46888.
    224. Federoff H, Lawrence D, Brownlee M. Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth. Diabetes. 1993 Apr; 42(4):509-13. PMID: 8454100.
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    225. Federoff H, Geschwind MD, Geller AI, Kessler JA. Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia. Proc Natl Acad Sci U S A. 1992 Mar 01; 89(5):1636-40. PMID: 1311846; PMCID: PMC48507.
    226. Lustig RH, Sudol M, Pfaff DW, Federoff H. Estrogenic regulation and sex dimorphism of growth-associated protein 43 kDa (GAP-43) messenger RNA in the rat. Brain Res Mol Brain Res. 1991 Sep; 11(2):125-32. PMID: 1661809.
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    227. Grabczyk E, Zuber MX, Federoff H, Ng SC, Pack A, Fishman MC. Cloning and Characterization of the Rat Gene Encoding GAP-43. Eur J Neurosci. 1990; 2(10):822-827. PMID: 12106089.
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    228. De la Monte SM, Federoff H, Ng SC, Grabczyk E, Fishman MC. GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system. Brain Res Dev Brain Res. 1989 Apr 01; 46(2):161-8. PMID: 2720952.
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    229. Federoff H, Grabczyk E, Fishman MC. Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids. J Biol Chem. 1988 Dec 25; 263(36):19290-5. PMID: 2461937.
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