Brian David Hitt

Title(s)Assistant Health Sciences Professor, Neurology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-6808
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tau seeding without tauopathy. J Biol Chem. 2024 Jan; 300(1):105545. LaCroix MS, Artikis E, Hitt BD, Beaver JD, Estill-Terpack SJ, Gleason K, Tamminga CA, Evers BM, White CL, Caughey B, Diamond MI. PMID: 38072056; PMCID: PMC10797195.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds. J Biol Chem. 2023 11; 299(11):105252. Hitt BD, Gupta A, Singh R, Yang T, Beaver JD, Shang P, White CL, Joachimiak LA, Diamond MI. PMID: 37714465; PMCID: PMC10582770.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. The influence of perceived stress on the human microbiome. BMC Res Notes. 2022 Jun 03; 15(1):193. Almand AT, Anderson AP, Hitt BD, Sitko JC, Joy RM, Easter BD, Almand EA. PMID: 35659718; PMCID: PMC9164568.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    4. CSF-Derived CD4+ T-Cell Diversity Is Reduced in Patients With Alzheimer Clinical Syndrome. Neurol Neuroimmunol Neuroinflamm. 2022 01; 9(1). Joshi C, Sivaprakasam K, Christley S, Ireland S, Rivas J, Zhang W, Sader D, Logan R, Lambracht-Washington D, Rosenberg R, Cullum M, Hitt B, Li QZ, Barber R, Greenberg B, Cowell L, Zhang R, Stowe A, Huebinger R, Kelley B, Monson N. PMID: 34848502; PMCID: PMC8631792.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    5. Ultrasensitive tau biosensor cells detect no seeding in Alzheimer's disease CSF. Acta Neuropathol Commun. 2021 05 26; 9(1):99. Hitt BD, Vaquer-Alicea J, Manon VA, Beaver JD, Kashmer OM, Garcia JN, Diamond MI. PMID: 34039426; PMCID: PMC8152020.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    6. Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism‡. Biol Reprod. 2021 01 04; 104(1):197-210. Bidne KL, Rister AL, McCain AR, Hitt BD, Dodds ED, Wood JR. PMID: 33048132; PMCID: PMC7946805.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    7. The objective function controversy for group testing: Much ado about nothing? Stat Med. 2019 10 30; 38(24):4912-4923. Hitt BD, Bilder CR, Tebbs JM, McMahan CS. PMID: 31469188; PMCID: PMC6800791.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    8. Spatial variation in western corn rootworm (Coleoptera: Chrysomelidae) susceptibility to Cry3 toxins in Nebraska. PLoS One. 2018; 13(11):e0208266. Reinders JD, Hitt BD, Stroup WW, French BW, Meinke LJ. PMID: 30496268; PMCID: PMC6264490.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsPHPublic Health
    9. β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. J Biol Chem. 2012 Nov 09; 287(46):38408-25. Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R. PMID: 22988240; PMCID: PMC3493884.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    10. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener. 2010 Aug 23; 5:31. Hitt BD, Jaramillo TC, Chetkovich DM, Vassar R. PMID: 20731874; PMCID: PMC2933677.
      View in: PubMed   Mentions: 61     Fields:    
    11. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009. O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R. PMID: 19109907; PMCID: PMC2667382.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    12. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Gen Physiol. 2008 Aug; 132(2):i1. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18663130.
      View in: PubMed   Mentions: 11     Fields:    
    13. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18591429; PMCID: PMC2442205.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    14. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci. 2007 Apr 04; 27(14):3639-49. Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R. PMID: 17409228; PMCID: PMC6672403.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansAnimalsCells
    15. Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease. J Neurochem. 2005 Sep; 94(6):1711-8. Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM. PMID: 16156741.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    16. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1145-52. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PMID: 15336962.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
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