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Baram, Tallie Z.

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentPediatrics
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-6478, 1063
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    Collapse Research 
    Collapse Research Activities and Funding
    Cognitive Deficits After Experimental Febrile Seizures: Neurobiology & Biomarkers
    NIH/NINDS R01NS108296Jul 15, 2018 - Apr 30, 2023
    Role: Co-Principal Investigator
    Fragmented early life environmental and emotional / cognitive vulnerabilities
    NIH/NIMH P50MH096889Jun 17, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Cognitive Deficits After Experimental Febrile Seizures: Neurobiology &Biomarkers
    NIH/NINDS R01NS078279Sep 30, 2011 - Jun 30, 2016
    Role: Co-Principal Investigator
    MRI predicts epileptogenesis and cognitive deficits
    NIH/NINDS R21NS049618Aug 2, 2004 - Apr 30, 2007
    Role: Principal Investigator
    Epilepsy Research Training Program
    NIH/NINDS T32NS045540Jul 1, 2003 - Jun 30, 2019
    Role: Principal Investigator
    EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    NIH/NINDS R01NS039307Sep 1, 2000 - Aug 31, 2005
    Role: Principal Investigator
    Effects of Early-Life Experience: Role of CRH
    NIH/NIMH R01MH073136Dec 1, 1999 - May 31, 2021
    Role: Principal Investigator
    SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHO
    NIH/NIGMS T35GM008630Aug 1, 1997 - Apr 30, 2002
    Role: Co-Principal Investigator
    Epileptogenesis following FSE: mechanisms, biomarkers, prevention
    NIH/NINDS R01NS035439Apr 1, 1997 - Jul 31, 2019
    Role: Principal Investigator
    Febrile Seizure Model - Neuronal Injury and Mechanisms
    NIH/NINDS R37NS035439Apr 1, 1997 - Jun 30, 2014
    Role: Principal Investigator
    SPECIFIC RECEPTOR MEDIATION OF CRH-INDUCED SEIZURES
    NIH/NICHD R41HD034975Apr 1, 1997 - Mar 31, 1998
    Role: Principal Investigator
    CRH in stress-induced hippocampal neuroplasticity
    NIH/NINDS R01NS028912Mar 1, 1992 - Jun 30, 2015
    Role: Principal Investigator
    MOLECULAR MECHANISM OF CRH EXPRESSION
    NIH/NINDS K08NS001307Aug 1, 1988 - Jul 31, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Risbrough VB, Glynn LM, Davis EP, Sandman CA, Obenaus A, Stern HS, Keator DB, Yassa MA, Baram T, Baker DG. Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? : Adolescent Anhedonia and Posttraumatic Disorders. Curr Top Behav Neurosci. 2018 May 24. PMID: 29796839.
      View in: PubMed
    2. Vogel Ciernia A, Laufer BI, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram T, LaSalle JM, Yasui DH. Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics. 2018 May 10; 1-13. PMID: 29613827.
      View in: PubMed
    3. Riley JD, Chen EE, Winsell J, Davis EP, Glynn LM, Baram T, Sandman CA, Small SL, Solodkin A. Network specialization during adolescence: Hippocampal effective connectivity in boys and girls. Neuroimage. 2018 Apr 09; 175:402-412. PMID: 29649560.
      View in: PubMed
    4. Sandman CA, Curran MM, Davis EP, Glynn LM, Head K, Baram T. Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH? Am J Psychiatry. 2018 May 01; 175(5):471-479. PMID: 29495899.
      View in: PubMed
    5. Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram T, Mahler SV. Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. Neurobiol Stress. 2018 Feb; 8:57-67. PMID: 29888304.
      View in: PubMed
    6. Glynn LM, Howland MA, Sandman CA, Davis EP, Phelan M, Baram T, Stern HS. Prenatal maternal mood patterns predict child temperament and adolescent mental health. J Affect Disord. 2018 03 01; 228:83-90. PMID: 29241049.
      View in: PubMed
    7. Davis EP, Stout SA, Molet J, Vegetabile B, Glynn LM, Sandman CA, Heins K, Stern H, Baram T. Exposure to unpredictable maternal sensory signals influences cognitive development across species. Proc Natl Acad Sci U S A. 2017 Sep 26; 114(39):10390-10395. PMID: 28893979.
      View in: PubMed
    8. Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram T. Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene. Biol Psychiatry. 2018 Jan 15; 83(2):137-147. PMID: 29033027.
      View in: PubMed
    9. Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram T. Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress. 2017 Sep; 20(5):421-448. PMID: 28617197.
      View in: PubMed
    10. Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH, Baram T. Neuroinflammation imaging markers for epileptogenesis. Epilepsia. 2017 07; 58 Suppl 3:11-19. PMID: 28675560.
      View in: PubMed
    11. Curran MM, Sandman CA, Poggi Davis E, Glynn LM, Baram T. Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity? PLoS One. 2017; 12(6):e0180311. PMID: 28658297.
      View in: PubMed
    12. Bolton JL, Molet J, Ivy A, Baram T. New insights into early-life stress and behavioral outcomes. Curr Opin Behav Sci. 2017 Apr; 14:133-139. PMID: 28413813.
      View in: PubMed
    13. Patterson KP, Barry JM, Curran MM, Singh-Taylor A, Brennan G, Rismanchi N, Page M, Noam Y, Holmes GL, Baram T. Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor. J Neurosci. 2017 Apr 05; 37(14):3799-3812. PMID: 28275159.
      View in: PubMed
    14. Hall AM, Brennan GP, Nguyen TM, Singh-Taylor A, Mun HS, Sargious MJ, Baram T. The Role of Sirt1 in Epileptogenesis. eNeuro. 2017 Jan-Feb; 4(1). PMID: 28197553.
      View in: PubMed
    15. Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram T. Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. J Neurosci. 2016 Nov 02; 36(44):11295-11307. PMID: 27807170.
      View in: PubMed
    16. Molet J, Maras PM, Kinney-Lang E, Harris NG, Rashid F, Ivy AS, Solodkin A, Obenaus A, Baram T. MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity. Hippocampus. 2016 12; 26(12):1618-1632. PMID: 27657911.
      View in: PubMed
    17. Barry JM, Sakkaki S, Barriere SJ, Patterson KP, Lenck-Santini PP, Scott RC, Baram T, Holmes GL. Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus. EBioMedicine. 2016 May; 7:175-90. PMID: 27322471; PMCID: PMC4909381.
    18. Brennan GP, Dey D, Chen Y, Patterson KP, Magnetta EJ, Hall AM, Dube CM, Mei YT, Baram T. Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks. Cell Rep. 2016 Mar 15; 14(10):2402-12. PMID: 26947066; PMCID: PMC4794429.
    19. Brennan GP, Baram T, Poolos NP. Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy. Cold Spring Harb Perspect Med. 2016 Mar 01; 6(3):a022384. PMID: 26931806.
      View in: PubMed
    20. Patterson KP, Brennan GP, Curran M, Kinney-Lang E, Dubé C, Rashid F, Ly C, Obenaus A, Baram T. Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis. eNeuro. 2015 Sep-Oct; 2(5). PMID: 26730400; PMCID: PMC4699830.
    21. Chen Y, Molet J, Gunn BG, Ressler K, Baram T. Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons. Endocrinology. 2015 Dec; 156(12):4769-80. PMID: 26402844; PMCID: PMC4655217 [Available on 12/01/16].
    22. Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram T, LaFerla FM. Short-term modern life-like stress exacerbates Aß-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015 Sep; 134(5):915-26. PMID: 26077803; PMCID: PMC4792118.
    23. Chen Y, Baram T. Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks. Neuropsychopharmacology. 2016 Jan; 41(1):197-206. PMID: 26105143; PMCID: PMC4677123 [Available on 01/01/17].
    24. Barry JM, Choy M, Dube C, Robbins A, Obenaus A, Lenck-Santini PP, Scott RC, Baram T, Holmes GL. T2 relaxation time post febrile status epilepticus predicts cognitive outcome. Exp Neurol. 2015 Jul; 269:242-52. PMID: 25939697; PMCID: PMC4446141.
    25. Singh-Taylor A, Korosi A, Molet J, Gunn BG, Baram T. Synaptic rewiring of stress-sensitive neurons by early-life experience: a mechanism for resilience? Neurobiol Stress. 2015 Jan 01; 1:109-115. PMID: 25530985.
      View in: PubMed
    26. Dubé CM, Molet J, Singh-Taylor A, Ivy A, Maras PM, Baram T. Hyper-excitability and epilepsy generated by chronic early-life stress. Neurobiol Stress. 2015; 2:10-19. PMID: 25884016.
      View in: PubMed
    27. McClelland S, Brennan GP, Dubé C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram T. The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife. 2014 Aug 12; 3:e01267. PMID: 25117540; PMCID: PMC4129437.
    28. Choy M, Dubé CM, Patterson K, Barnes SR, Maras P, Blood AB, Hasso AN, Obenaus A, Baram T. A novel, noninvasive, predictive epilepsy biomarker with clinical potential. J Neurosci. 2014 Jun 25; 34(26):8672-84. PMID: 24966369; PMCID: PMC4069350.
    29. Molet J, Maras PM, Avishai-Eliner S, Baram T. Naturalistic rodent models of chronic early-life stress. Dev Psychobiol. 2014 Dec; 56(8):1675-88. PMID: 24910169; PMCID: PMC4777289.
    30. Patterson KP, Baram T, Shinnar S. Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus. Neurotherapeutics. 2014 Apr; 11(2):242-50. PMID: 24604424; PMCID: PMC3996115.
    31. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram T. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28; 289(9):5889-903. PMID: 24403084; PMCID: PMC3937658.
    32. Choy M, Dubé CM, Ehrengruber M, Baram T. Inflammatory processes, febrile seizures, and subsequent epileptogenesis. Epilepsy Curr. 2014 Jan; 14(1 Suppl):15-22. PMID: 24955071; PMCID: PMC3966647.
    33. Nakamura Y, Shi X, Numata T, Mori Y, Inoue R, Lossin C, Baram T, Hirose S. Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PLoS One. 2013; 8(12):e80376. PMID: 24324597; PMCID: PMC3851455.
    34. Andres AL, Regev L, Phi L, Seese RR, Chen Y, Gall CM, Baram T. NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci. 2013 Oct 23; 33(43):16945-60. PMID: 24155300; PMCID: PMC3807024.
    35. Regev L, Baram T. Corticotropin releasing factor in neuroplasticity. Front Neuroendocrinol. 2014 Apr; 35(2):171-9. PMID: 24145148; PMCID: PMC3965598.
    36. Karsten CA, Baram T. How Does a Neuron "know" to Modulate Its Epigenetic Machinery in Response to Early-Life Environment/Experience? Front Psychiatry. 2013; 4:89. PMID: 23966959; PMCID: PMC3744051.
    37. Cope JL, Regev L, Chen Y, Korosi A, Rice CJ, Ji S, Rogge GA, Wood MA, Baram T. Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress. 2014 Jan; 17(1):39-50. PMID: 23768074; PMCID: PMC3869921.
    38. Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram T, Lynch G, Wood MA. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013 May; 16(5):552-61. PMID: 23525042; PMCID: PMC3777648.
    39. Baram T, Davis EP, Obenaus A, Sandman CA, Small SL, Solodkin A, Stern H. Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry. 2012 Sep; 169(9):907-15. PMID: 22885631; PMCID: PMC3483144.
    40. Noam Y, Phan L, McClelland S, Manders EM, Ehrengruber MU, Wadman WJ, Baram T, Chen Y. Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain. J Comp Neurol. 2012 Sep 01; 520(13):3013-34. PMID: 22434607; PMCID: PMC3393847.
    41. Baram T. The brain, seizures and epilepsy throughout life: understanding a moving target. Epilepsy Curr. 2012 Jul; 12(Suppl 3):7-12. PMID: 23476117; PMCID: PMC3588148.
    42. Dedeurwaerdere S, Friedman A, Fabene PF, Mazarati A, Murashima YL, Vezzani A, Baram T. Finding a better drug for epilepsy: antiinflammatory targets. Epilepsia. 2012 Jul; 53(7):1113-8. PMID: 22691043; PMCID: PMC3389561.
    43. Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram T, Anderson AE, Becker A, Esclapez M, Bernard C. Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. J Biol Chem. 2012 May 18; 287(21):17656-61. PMID: 22511771; PMCID: PMC3366832.
    44. Chen Y, Andres AL, Frotscher M, Baram T. Tuning synaptic transmission in the hippocampus by stress: the CRH system. Front Cell Neurosci. 2012; 6:13. PMID: 22514519; PMCID: PMC3322336.
    45. Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram T, Esclapez M, Bernard C. Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. J Neurosci. 2012 Mar 14; 32(11):3736-47. PMID: 22423094; PMCID: PMC3321843.
    46. Surges R, Kukley M, Brewster A, Rüschenschmidt C, Schramm J, Baram T, Beck H, Dietrich D. Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem Biophys Res Commun. 2012 Mar 30; 420(1):156-60. PMID: 22405820; PMCID: PMC3383809.
    47. Maras PM, Baram T. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012 May; 35(5):315-24. PMID: 22386641; PMCID: PMC3423222.
    48. Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram T, Stewart MG, Müller MB, Schmidt MV. Forebrain CRF1 modulates early-life stress-programmed cognitive deficits. J Neurosci. 2011 Sep 21; 31(38):13625-34. PMID: 21940453; PMCID: PMC3380621.
    49. McClelland S, Flynn C, Dubé C, Richichi C, Zha Q, Ghestem A, Esclapez M, Bernard C, Baram T. Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol. 2011 Sep; 70(3):454-64. PMID: 21905079; PMCID: PMC3177145.
    50. Noam Y, Bernard C, Baram T. Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol. 2011 Dec; 21(6):873-9. PMID: 21782415; PMCID: PMC3235400.
    51. Stafstrom CE, Arnason BG, Baram T, Catania A, Cortez MA, Glauser TA, Pranzatelli MR, Riikonen R, Rogawski MA, Shinnar S, Swann JW. Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol. 2011 Nov; 26(11):1411-21. PMID: 21719797.
      View in: PubMed
    52. Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram T, Chetkovich DM. Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. J Biol Chem. 2011 Jun 10; 286(23):20823-34. PMID: 21504900; PMCID: PMC3121500.
    53. McClelland S, Dubé CM, Yang J, Baram T. Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. Neurosci Lett. 2011 Jun 27; 497(3):155-62. PMID: 21356275; PMCID: PMC3109205.
    54. McClelland S, Korosi A, Cope J, Ivy A, Baram T. Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem. 2011 Jul; 96(1):79-88. PMID: 21338703; PMCID: PMC3111759.
    55. Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram T, Müller MB, Schmidt MV. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol Dis. 2011 Jun; 42(3):300-10. PMID: 21296667; PMCID: PMC3200197.
    56. Baram T, Jensen FE, Brooks-Kayal A. Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr. 2011 Jan; 11(1):21-6. PMID: 21461261; PMCID: PMC3063568.
    57. Hill EL, Hosie S, Mulligan RS, Richards KL, Davies PJ, Dubé CM, Baram T, Reid CA, Jones MV, Petrou S. Temperature elevation increases GABA(A) -mediated cortical inhibition in a mouse model of genetic epilepsy. Epilepsia. 2011 Jan; 52(1):179-84. PMID: 21219304; PMCID: PMC3354703.
    58. Vezzani A, French J, Bartfai T, Baram T. The role of inflammation in epilepsy. Nat Rev Neurol. 2011 Jan; 7(1):31-40. PMID: 21135885; PMCID: PMC3378051.
    59. Korosi A, Baram T. Plasticity of the stress response early in life: mechanisms and significance. Dev Psychobiol. 2010 Nov; 52(7):661-70. PMID: 20862706; PMCID: PMC3203734.
    60. Pellock JM, Hrachovy R, Shinnar S, Baram T, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. Infantile spasms: a U.S. consensus report. Epilepsia. 2010 Oct; 51(10):2175-89. PMID: 20608959.
      View in: PubMed
    61. Ivy AS, Rex CS, Chen Y, Dubé C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram T. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci. 2010 Sep 29; 30(39):13005-15. PMID: 20881118; PMCID: PMC2991143.
    62. Bale TL, Baram T, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 Aug 15; 68(4):314-9. PMID: 20674602; PMCID: PMC3168778.
    63. Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, Baram T. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13123-8. PMID: 20615973; PMCID: PMC2919915.
    64. Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, Baram T. Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci. 2010 Jun 02; 30(22):7484-94. PMID: 20519523; PMCID: PMC2906240.
    65. Dibbens LM, Reid CA, Hodgson B, Thomas EA, Phillips AM, Gazina E, Cromer BA, Clarke AL, Baram T, Scheffer IE, Berkovic SF, Petrou S. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann Neurol. 2010 Apr; 67(4):542-6. PMID: 20437590; PMCID: PMC3383007.
    66. Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram T. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem. 2010 May 07; 285(19):14724-36. PMID: 20215108; PMCID: PMC2863223.
    67. Martin MS, Dutt K, Papale LA, Dubé CM, Dutton SB, de Haan G, Shankar A, Tufik S, Meisler MH, Baram T, Goldin AL, Escayg A. Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem. 2010 Mar 26; 285(13):9823-34. PMID: 20100831; PMCID: PMC2843231.
    68. Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL, Baram T. Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci. 2010 Jan 13; 30(2):703-13. PMID: 20071535; PMCID: PMC2822406.
    69. Noam Y, Baram T. Hyperpolarized views on the roles of the hyperpolarization-activated channels in neuronal excitability. Epilepsy Curr. 2010 Jan; 10(1):28-30. PMID: 20126337; PMCID: PMC2812721.
    70. Korosi A, Baram T. The pathways from mother's love to baby's future. Front Behav Neurosci. 2009; 3:27. PMID: 19826614; PMCID: PMC2759360.
    71. Kanyshkova T, Pawlowski M, Meuth P, Dubé C, Bender RA, Brewster AL, Baumann A, Baram T, Pape HC, Budde T. Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J Neurosci. 2009 Jul 08; 29(27):8847-57. PMID: 19587292; PMCID: PMC2768285.
    72. Joëls M, Baram T. The neuro-symphony of stress. Nat Rev Neurosci. 2009 06; 10(6):459-66. PMID: 19339973; PMCID: PMC2844123.
    73. Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram T, Macdonald RL, Chetkovich DM. Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci. 2009 May 13; 29(19):6250-65. PMID: 19439603; PMCID: PMC2730639.
    74. Kerjan G, Koizumi H, Han EB, Dubé CM, Djakovic SN, Patrick GN, Baram T, Heinemann SF, Gleeson JG. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6766-71. PMID: 19342486; PMCID: PMC2672532.
    75. Dubé CM, Brewster AL, Baram T. Febrile seizures: mechanisms and relationship to epilepsy. Brain Dev. 2009 May; 31(5):366-71. PMID: 19232478; PMCID: PMC2698702.
    76. Dubé CM, Zhou JL, Hamamura M, Zhao Q, Ring A, Abrahams J, McIntyre K, Nalcioglu O, Shatskih T, Baram T, Holmes GL. Cognitive dysfunction after experimental febrile seizures. Exp Neurol. 2009 Jan; 215(1):167-77. PMID: 19000675; PMCID: PMC2649663.
    77. Bender RA, Baram T. Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks. Prog Neurobiol. 2008 Nov; 86(3):129-40. PMID: 18834920; PMCID: PMC2606691.
    78. Rice CJ, Sandman CA, Lenjavi MR, Baram T. A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology. 2008 Oct; 149(10):4892-900. PMID: 18566122; PMCID: PMC2582918.
    79. Chen Y, Dubé CM, Rice CJ, Baram T. Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci. 2008 Mar 12; 28(11):2903-11. PMID: 18337421; PMCID: PMC2409370.
    80. Korosi A, Baram T. The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol. 2008 Apr 07; 583(2-3):204-14. PMID: 18275957; PMCID: PMC2329668.
    81. Zha Q, Brewster AL, Richichi C, Bender RA, Baram T. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. J Neurochem. 2008 Apr; 105(1):68-77. PMID: 17988239; PMCID: PMC2747799.
    82. Baram T. Go "West," young man...The quest for animal models of infantile spasms (West syndrome). Epilepsy Curr. 2007 Nov-Dec; 7(6):165-7. PMID: 18049727; PMCID: PMC2096721.
    83. Dubé CM, Brewster AL, Richichi C, Zha Q, Baram T. Fever, febrile seizures and epilepsy. Trends Neurosci. 2007 Oct; 30(10):490-6. PMID: 17897728; PMCID: PMC2766556.
    84. Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram T. Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis. 2008 Feb; 29(2):297-305. PMID: 17964174; PMCID: PMC2292123.
    85. Noam Y, Baram T. Ps in the (channel) pod are not alike... Epilepsy Curr. 2007 Sep-Oct; 7(5):136-7. PMID: 17998975; PMCID: PMC2043134.
    86. Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram T. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 2007 Apr 25; 27(17):4697-706. PMID: 17460082; PMCID: PMC3086816.
    87. Vezzani A, Baram T. New roles for interleukin-1 Beta in the mechanisms of epilepsy. Epilepsy Curr. 2007 Mar-Apr; 7(2):45-50. PMID: 17505552; PMCID: PMC1867084.
    88. Baram T. Models for infantile spasms: an arduous journey to the Holy Grail... Ann Neurol. 2007 Feb; 61(2):89-91. PMID: 17315207; PMCID: PMC2917175.
    89. Bender RA, Baram T. Epileptogenesis in the developing brain: what can we learn from animal models? Epilepsia. 2007; 48 Suppl 5:2-6. PMID: 17910574; PMCID: PMC2735872.
    90. Surges R, Brewster AL, Bender RA, Beck H, Feuerstein TJ, Baram T. Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur J Neurosci. 2006 Jul; 24(1):94-104. PMID: 16882011; PMCID: PMC2919221.
    91. Kuisle M, Wanaverbecq N, Brewster AL, Frère SG, Pinault D, Baram T, Lüthi A. Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy. J Physiol. 2006 Aug 15; 575(Pt 1):83-100. PMID: 16728450; PMCID: PMC1819420.
    92. Brewster AL, Chen Y, Bender RA, Yeh A, Shigemoto R, Baram T. Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cereb Cortex. 2007 Mar; 17(3):702-12. PMID: 16648453; PMCID: PMC3100721.
    93. Fenoglio KA, Brunson KL, Baram T. Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects. Front Neuroendocrinol. 2006 Jul; 27(2):180-92. PMID: 16603235; PMCID: PMC2937188.
    94. Fenoglio KA, Chen Y, Baram T. Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions. J Neurosci. 2006 Mar 01; 26(9):2434-42. PMID: 16510721; PMCID: PMC2408688.
    95. Dubé C, Richichi C, Bender RA, Chung G, Litt B, Baram T. Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain. 2006 Apr; 129(Pt 4):911-22. PMID: 16446281; PMCID: PMC3100674.
    96. Bender RA, Galindo R, Mameli M, Gonzalez-Vega R, Valenzuela CF, Baram T. Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. Eur J Neurosci. 2005 Nov; 22(10):2669-74. PMID: 16307610; PMCID: PMC2927207.
    97. Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram T. Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci. 2005 Oct 12; 25(41):9328-38. PMID: 16221841; PMCID: PMC3100717.
    98. Fenoglio KA, Brunson KL, Avishai-Eliner S, Stone BA, Kapadia BJ, Baram T. Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology. 2005 Sep; 146(9):4090-6. PMID: 15932935; PMCID: PMC3100718.
    99. Brewster AL, Bernard JA, Gall CM, Baram T. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):200-7. PMID: 15837575; PMCID: PMC2930785.
    100. Baram T. When a rat runs cold and hot... Epilepsy Curr. 2005 Mar-Apr; 5(2):81-2. PMID: 16059444; PMCID: PMC1176316.
    101. Dubé C, Brunson KL, Eghbal-Ahmadi M, Gonzalez-Vega R, Baram T. Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. J Mol Neurosci. 2005; 25(3):275-84. PMID: 15800380; PMCID: PMC2930787.
    102. Dubé C, Vezzani A, Behrens M, Bartfai T, Baram T. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol. 2005 Jan; 57(1):152-5. PMID: 15622539; PMCID: PMC2909879.
    103. Brunson KL, Baram T, Bender RA. Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels. Hippocampus. 2005; 15(4):491-501. PMID: 15744738; PMCID: PMC2921196.
    104. Dubé C, Yu H, Nalcioglu O, Baram T. Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death. Ann Neurol. 2004 Nov; 56(5):709-14. PMID: 15389889; PMCID: PMC3084032.
    105. Chen Y, Bender RA, Brunson KL, Pomper JK, Grigoriadis DE, Wurst W, Baram T. Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15782-7. PMID: 15496472; PMCID: PMC524840.
    106. Fenoglio KA, Brunson KL, Avishai-Eliner S, Chen Y, Baram T. Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression. Endocrinology. 2004 Jun; 145(6):2702-6. PMID: 15044366; PMCID: PMC3088480.
    107. Bender RA, Dubé C, Baram T. Febrile seizures and mechanisms of epileptogenesis: insights from an animal model. Adv Exp Med Biol. 2004; 548:213-25. PMID: 15250596; PMCID: PMC3086822.
    108. Baram T. Long-term neuroplasticity and functional consequences of single versus recurrent early-life seizures. Ann Neurol. 2003 Dec; 54(6):701-5. PMID: 14681879; PMCID: PMC2981791.
    109. Santoro B, Baram T. The multiple personalities of h-channels. Trends Neurosci. 2003 Oct; 26(10):550-4. PMID: 14522148; PMCID: PMC2924161.
    110. Baram T. Treatment of infantile spasms: the ideal and the mundane. Epilepsia. 2003 Aug; 44(8):993-4. PMID: 12887429; PMCID: PMC3100716.
    111. Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram T. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci. 2003 Jul 30; 23(17):6826-36. PMID: 12890777; PMCID: PMC3100807.
    112. Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram T. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol. 2003 Jun; 53(6):711-7. PMID: 12783416; PMCID: PMC2930774.
    113. Brunson KL, Chen Y, Avishai-Eliner S, Baram T. Stress and the developing hippocampus: a double-edged sword? Mol Neurobiol. 2003 Apr; 27(2):121-36. PMID: 12777683; PMCID: PMC3084035.
    114. Bender RA, Dubé C, Gonzalez-Vega R, Mina EW, Baram T. Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus. 2003; 13(3):399-412. PMID: 12722980; PMCID: PMC2927853.
    115. Roozendaal B, Brunson KL, Holloway BL, McGaugh JL, Baram T. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13908-13. PMID: 12361983; PMCID: PMC129796.
    116. Avishai-Eliner S, Brunson KL, Sandman CA, Baram T. Stressed-out, or in (utero)? Trends Neurosci. 2002 Oct; 25(10):518-24. PMID: 12220880.
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    117. Brunson KL, Grigoriadis DE, Lorang MT, Baram T. Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. Exp Neurol. 2002 Jul; 176(1):75-86. PMID: 12093084; PMCID: PMC2930769.
    118. Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M, Baram T. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci. 2002 Jun 01; 22(11):4591-9. PMID: 12040066; PMCID: PMC3372984.
    119. Eling P, Renier WO, Pomper J, Baram T. The mystery of the Doctor's son, or the riddle of West syndrome. Neurology. 2002 Mar 26; 58(6):953-5. PMID: 11914414; PMCID: PMC3093242.
    120. Baram T, Eghbal-Ahmadi M, Bender RA. Is neuronal death required for seizure-induced epileptogenesis in the immature brain? Prog Brain Res. 2002; 135:365-75. PMID: 12143355; PMCID: PMC3084550.
    121. Baram T. What are the reasons for the strikingly different approaches to the use of ACTH in infants with West syndrome? Brain Dev. 2001 Nov; 23(7):647-8. PMID: 11701270; PMCID: PMC3100719.
    122. Baram T, Mitchell WG, Brunson K, Haden E. Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. Dev Neurosci. 1999 Nov; 21(3-5):281-9. PMID: 10575251; PMCID: PMC3139473.
    123. Baram T, Chalmers DT, Chen C, Koutsoukos Y, De Souza EB. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997 Oct 03; 770(1-2):89-95. PMID: 9372207; PMCID: PMC3387933.