Raju Metherate

Title(s)Professor and Associate Dean of Undergraduate Education, Neurobiology & Behavior
SchoolSchool of Biological Sciences
Address1332 Biological Sciences III
Zot 4550
Irvine CA 92697
Phone(949) 824-6141
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    Collapse Research 
    Collapse Research Activities and Funding
    Using nicotine to reverse age-related auditory processing deficits
    NIH R01AG067073Jan 1, 2021 - Dec 31, 2025
    Role: Principal Investigator
    Nicotinic enhancement of auditory-cognitive processing
    NIH R01DC017687Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Functions of Nicotine Receptors in Sensory Neocortex
    NIH R01DC013200Jul 1, 2013 - Dec 31, 2018
    Role: Principal Investigator
    NIDCD T32 Interdisciplinary Training Program in Hearing Research
    NIH T32DC010775Jul 1, 2010 - Jun 30, 2025
    Role: Principal Investigator
    UC Irvine Core Center for Hearing and Communication Research
    NIH P30DC008369Jul 1, 2006 - Mar 31, 2017
    Role: Principal Investigator
    Functions of Nicotine Receptors in Sensory Neocortex
    NIH R01DA012929Jul 1, 2000 - Jul 30, 2013
    Role: Principal Investigator
    Cellular Mechanisms of Aditory Cortex Function
    NIH R01DC002967Sep 30, 1996 - Feb 28, 2009
    Role: Principal Investigator
    CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    NIH R29DC002967Sep 30, 1996 - Feb 28, 2003
    Role: Principal Investigator
    CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    NIH R55DC002967Sep 30, 1996 - Jun 30, 1997
    Role: Principal Investigator
    FUNCTION OF ACH IN AUDITORY CORTEX RESPONSE PLASTICITY
    NIH F32DC000002Mar 20, 1989
    Role: Principal Investigator
    FUNCTION OF ACH IN AUDITORY CORTEX RESPONSE PLASTICITY
    NIH F32NS008001Oct 21, 1986
    Role: Principal Investigator
    THE ROLE OF ACETYLCHOLINE IN THE SOMATOSENSORY CORTEX
    NIH F31MH008996Jun 1, 1983
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alpha-2 nicotinic acetylcholine receptors regulate spectral integration in auditory cortex. Front Neural Circuits. 2024; 18:1492452. Intskirveli I, Gil S, Lazar R, Metherate R. PMID: 39553292; PMCID: PMC11563825.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers. Sci Rep. 2021 06 23; 11(1):13187. Sun S, Kapolowicz MR, Richardson M, Metherate R, Zeng FG. PMID: 34162968; PMCID: PMC8222263.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Nicotine Enhances Amplitude and Consistency of Timing of Responses to Acoustic Trains in A1. Front Neural Circuits. 2021; 15:597401. Intskirveli I, Metherate R. PMID: 33679335; PMCID: PMC7935554.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Nicotine enhances auditory processing in healthy and normal-hearing young adult nonsmokers. Psychopharmacology (Berl). 2020 Mar; 237(3):833-840. Pham CQ, Kapolowicz MR, Metherate R, Zeng FG. PMID: 31832719; PMCID: PMC7039769.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    5. Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex. Synapse. 2019 09; 73(9):e22116. Askew CE, Lopez AJ, Wood MA, Metherate R. PMID: 31081950; PMCID: PMC6767604.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    6. Enhanced Sensory-Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors. Nicotine Tob Res. 2019 02 18; 21(3):377-382. Gil SM, Metherate R. PMID: 30137439; PMCID: PMC6379024.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    7. Development of fluorescence imaging probes for nicotinic acetylcholine α4β2∗ receptors. Bioorg Med Chem Lett. 2018 02 01; 28(3):371-377. Samra GK, Intskirveli I, Govind AP, Liang C, Lazar R, Green WN, Metherate R, Mukherjee J. PMID: 29277457; PMCID: PMC6004331.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways. J Comp Neurol. 2018 Jan 01; 526(1):80-95. Mukherjee J, Lao PJ, Betthauser TJ, Samra GK, Pan ML, Patel IH, Liang C, Metherate R, Christian BT. PMID: 28875553; PMCID: PMC5788574.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. Systemic Nicotine Increases Gain and Narrows Receptive Fields in A1 via Integrated Cortical and Subcortical Actions. eNeuro. 2017 May-Jun; 4(3). Askew C, Intskirveli I, Metherate R. PMID: 28660244; PMCID: PMC5480142.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    10. Spectral breadth and laminar distribution of thalamocortical inputs to A1. J Neurophysiol. 2016 Apr; 115(4):2083-94. Intskirveli I, Joshi A, Vizcarra-Chacón BJ, Metherate R. PMID: 26888102; PMCID: PMC4869500.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    11. Synaptic interactions and inhibitory regulation in auditory cortex. Biol Psychol. 2016 Apr; 116:4-9. Askew CE, Metherate R. PMID: 26555718; PMCID: PMC4808603.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Convergence of nicotine-induced and auditory-evoked neural activity activates ERK in auditory cortex. Synapse. 2013 Aug; 67(8):455-68. Kawai HD, La M, Kang HA, Hashimoto Y, Liang K, Lazar R, Metherate R. PMID: 23401204; PMCID: PMC3775467.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex. Neurobiol Learn Mem. 2013 Mar; 101:75-84. Guo F, Intskirveli I, Blake DT, Metherate R. PMID: 23357284; PMCID: PMC3602403.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    14. Nicotinic filtering of sensory processing in auditory cortex. Front Behav Neurosci. 2012; 6:44. Metherate R, Intskirveli I, Kawai HD. PMID: 22833720; PMCID: PMC3400128.
      View in: PubMed   Mentions: 19  
    15. Nicotinic neuromodulation in auditory cortex requires MAPK activation in thalamocortical and intracortical circuits. J Neurophysiol. 2012 May; 107(10):2782-93. Intskirveli I, Metherate R. PMID: 22357798; PMCID: PMC3362282.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior. Synapse. 2012 May; 66(5):418-34. Bieszczad KM, Kant R, Constantinescu CC, Pandey SK, Kawai HD, Metherate R, Weinberger NM, Mukherjee J. PMID: 22213342; PMCID: PMC3292694.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    17. Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex. PLoS One. 2011; 6(10):e26192. Intskirveli I, Metherate R, Cramer KS. PMID: 22022561; PMCID: PMC3192161.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    18. Heightened nicotinic regulation of auditory cortex during adolescence. J Neurosci. 2011 Oct 05; 31(40):14367-77. Kawai HD, Kang HA, Metherate R. PMID: 21976522; PMCID: PMC3210642.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    19. Functional connectivity and cholinergic modulation in auditory cortex. Neurosci Biobehav Rev. 2011 Nov; 35(10):2058-63. Metherate R. PMID: 21144860; PMCID: PMC3139107.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    20. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. PMID: 19339596; PMCID: PMC6665357.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    21. Nicotinic modulation of tone-evoked responses in auditory cortex reflects the strength of prior auditory learning. Neurobiol Learn Mem. 2008 Jul; 90(1):138-46. Liang K, Poytress BS, Weinberger NM, Metherate R. PMID: 18378471; PMCID: PMC2464281.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    22. Nicotinic control of axon excitability regulates thalamocortical transmission. Nat Neurosci. 2007 Sep; 10(9):1168-75. Kawai H, Lazar R, Metherate R. PMID: 17704774.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    23. Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats. Eur J Neurosci. 2006 Aug; 24(3):857-66. Liang K, Poytress BS, Chen Y, Leslie FM, Weinberger NM, Metherate R. PMID: 16848798.
      View in: PubMed   Mentions: 43  Translation:Animals
    24. Spectral integration in auditory cortex: mechanisms and modulation. Hear Res. 2005 Aug; 206(1-2):146-58. Metherate R, Kaur S, Kawai H, Lazar R, Liang K, Rose HJ. PMID: 16081005.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    25. Auditory thalamocortical transmission is reliable and temporally precise. J Neurophysiol. 2005 Sep; 94(3):2019-30. Rose HJ, Metherate R. PMID: 15928054.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    26. Spectral integration in primary auditory cortex: laminar processing of afferent input, in vivo and in vitro. Neuroscience. 2005; 134(3):1033-45. Kaur S, Rose HJ, Lazar R, Liang K, Metherate R. PMID: 15979241.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    27. Intracortical pathways determine breadth of subthreshold frequency receptive fields in primary auditory cortex. J Neurophysiol. 2004 Jun; 91(6):2551-67. Kaur S, Lazar R, Metherate R. PMID: 14749307.
      View in: PubMed   Mentions: 89     Fields:    Translation:Animals
    28. Synaptic mechanisms and cholinergic regulation in auditory cortex. Prog Brain Res. 2004; 145:143-56. Metherate R, Hsieh CY. PMID: 14650913.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    29. Nicotinic acetylcholine receptors in sensory cortex. Learn Mem. 2004 Jan-Feb; 11(1):50-9. Metherate R. PMID: 14747517.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    30. Regulation of glutamate synapses by nicotinic acetylcholine receptors in auditory cortex. Neurobiol Learn Mem. 2003 Nov; 80(3):285-90. Metherate R, Hsieh CY. PMID: 14521870.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    31. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PMID: 12895417.
      View in: PubMed   Mentions: 1903     Fields:    Translation:HumansAnimalsCells
    32. Spectral interactions, but no mismatch negativity, in auditory cortex of anesthetized rat. Hear Res. 2003 Jul; 181(1-2):51-6. Lazar R, Metherate R. PMID: 12855362.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    33. Postnatal development of NR2A and NR2B mRNA expression in rat auditory cortex and thalamus. J Assoc Res Otolaryngol. 2002 Dec; 3(4):479-87. Hsieh CY, Chen Y, Leslie FM, Metherate R. PMID: 12486601; PMCID: PMC3202444.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    34. Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. Brain Res Dev Brain Res. 2002 Jan 31; 133(1):19-25. Hsieh CY, Leslie FM, Metherate R. PMID: 11850060.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    35. Auditory thalamocortical synaptic transmission in vitro. J Neurophysiol. 2002 Jan; 87(1):361-84. Cruikshank SJ, Rose HJ, Metherate R. PMID: 11784756.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    36. Parvalbumin and calbindin are differentially distributed within primary and secondary subregions of the mouse auditory forebrain. Neuroscience. 2001; 105(3):553-69. Cruikshank SJ, Killackey HP, Metherate R. PMID: 11516823.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    37. Thalamic stimulation largely elicits orthodromic, rather than antidromic, cortical activation in an auditory thalamocortical slice. Neuroscience. 2001; 106(2):331-40. Rose HJ, Metherate R. PMID: 11566504.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    38. Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist. Brain Res. 2000 Oct 13; 880(1-2):51-64. Hsieh CY, Cruikshank SJ, Metherate R. PMID: 11032989.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    39. A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex. J Neurosci. 2000 Aug 15; 20(16):6106-16. Aramakis VB, Hsieh CY, Leslie FM, Metherate R. PMID: 10934260; PMCID: PMC6772566.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    40. Intrinsic electrophysiology of neurons in thalamorecipient layers of developing rat auditory cortex. Brain Res Dev Brain Res. 1999 Jun 02; 115(2):131-44. Metherate R, Aramakis VB. PMID: 10407131.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    41. Thalamocortical inputs trigger a propagating envelope of gamma-band activity in auditory cortex in vitro. Exp Brain Res. 1999 May; 126(2):160-74. Metherate R, Cruikshank SJ. PMID: 10369139.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    42. Nicotine selectively enhances NMDA receptor-mediated synaptic transmission during postnatal development in sensory neocortex. J Neurosci. 1998 Oct 15; 18(20):8485-95. Aramakis VB, Metherate R. PMID: 9763491; PMCID: PMC6792829.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    43. Synaptic mechanisms in auditory cortex function. Front Biosci. 1998 May 06; 3:d494-501. Metherate R. PMID: 9569228.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    44. Acetylcholine modifies neuronal acoustic rate-level functions in guinea pig auditory cortex by an action at muscarinic receptors. Synapse. 1990; 6(4):364-8. Metherate R, Ashe JH, Weinberger NM. PMID: 2287993.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    45. Cholinergic modulation of responses to single tones produces tone-specific receptive field alterations in cat auditory cortex. Synapse. 1990; 6(2):133-45. Metherate R, Weinberger NM. PMID: 2237776.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    46. Acetylcholine produces stimulus-specific receptive field alterations in cat auditory cortex. Brain Res. 1989 Feb 20; 480(1-2):372-7. Metherate R, Weinberger NM. PMID: 2713663.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    47. A thalamic terminus of the lateral cervical nucleus: the lateral division of the posterior nuclear group. J Neurophysiol. 1986 Dec; 56(6):1498-520. Metherate RS, da Costa DC, Herron P, Dykes RW. PMID: 3027272.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    48. Gel route preparation of low fusing dental porcelain frit. J Biomed Mater Res. 1983 Jul; 17(4):691-713. Mabie CP, Menis DL, Whitenton EP, Trout RL, Metherate RS, Ferry CH. PMID: 6309855.
      View in: PubMed   Mentions:    Fields:    
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