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Metherate, Raju

TitleProfessor and Associate Dean of Undergraduate Education
InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address1332 Biological Sciences III
Zot 4550
Irvine CA 92697
Phone(949) 824-6141
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    Collapse Research 
    Collapse Research Activities and Funding
    Functions of Nicotine Receptors in Sensory Neocortex
    NIH/NIDCD R01DC013200Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Interdisciplinary Training Program in Hearing Research
    NIH/NIDCD T32DC010775Jul 1, 2010 - Jun 30, 2020
    Role: Principal Investigator
    UC Irvine Core Center for Hearing and Communication Research
    NIH/NIDCD P30DC008369Jul 1, 2006 - Mar 31, 2017
    Role: Principal Investigator
    Functions of Nicotine Receptors in Sensory Neocortex
    NIH/NIDA R01DA012929Jul 1, 2000 - Jul 30, 2013
    Role: Principal Investigator
    Cellular Mechanisms of Aditory Cortex Function
    NIH/NIDCD R01DC002967Sep 30, 1996 - Feb 28, 2009
    Role: Principal Investigator
    CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    NIH/NIDCD R29DC002967Sep 30, 1996 - Feb 28, 2003
    Role: Principal Investigator
    CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    NIH/NIDCD R55DC002967Sep 30, 1996 - Jun 30, 1997
    Role: Principal Investigator
    FUNCTION OF ACH IN AUDITORY CORTEX RESPONSE PLASTICITY
    NIH/NIDCD F32DC000002Mar 20, 1989
    Role: Principal Investigator
    FUNCTION OF ACH IN AUDITORY CORTEX RESPONSE PLASTICITY
    NIH/NINDS F32NS008001Oct 21, 1986
    Role: Principal Investigator
    THE ROLE OF ACETYLCHOLINE IN THE SOMATOSENSORY CORTEX
    NIH/NIMH F31MH008996Jun 1, 1983
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gil SM, Metherate R. Enhanced Sensory-Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors. Nicotine Tob Res. 2018 Aug 18. PMID: 30137439.
      View in: PubMed
    2. Samra GK, Intskirveli I, Govind AP, Liang C, Lazar R, Green WN, Metherate R, Mukherjee J. Development of fluorescence imaging probes for nicotinic acetylcholine a4ß2* receptors. Bioorg Med Chem Lett. 2017 Dec 17. PMID: 29277457.
      View in: PubMed
    3. Mukherjee J, Lao PJ, Betthauser TJ, Samra GK, Pan ML, Patel IH, Liang C, Metherate R, Christian BT. Human brain imaging of nicotinic acetylcholine a4ß2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways. J Comp Neurol. 2018 Jan 01; 526(1):80-95. PMID: 28875553.
      View in: PubMed
    4. Askew C, Intskirveli I, Metherate R. Systemic Nicotine Increases Gain and Narrows Receptive Fields in A1 via Integrated Cortical and Subcortical Actions. eNeuro. 2017 May-Jun; 4(3). PMID: 28660244.
      View in: PubMed
    5. Intskirveli I, Joshi A, Vizcarra-Chacón BJ, Metherate R. Spectral breadth and laminar distribution of thalamocortical inputs to A1. J Neurophysiol. 2016 Apr; 115(4):2083-94. PMID: 26888102; PMCID: PMC4869500 [Available on 04/01/17].
    6. Askew CE, Metherate R. Synaptic interactions and inhibitory regulation in auditory cortex. Biol Psychol. 2016 Apr; 116:4-9. PMID: 26555718; PMCID: PMC4808603 [Available on 04/01/17].
    7. Kawai HD, La M, Kang HA, Hashimoto Y, Liang K, Lazar R, Metherate R. Convergence of nicotine-induced and auditory-evoked neural activity activates ERK in auditory cortex. Synapse. 2013 Aug; 67(8):455-68. PMID: 23401204; PMCID: PMC3775467.
    8. Guo F, Intskirveli I, Blake DT, Metherate R. Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex. Neurobiol Learn Mem. 2013 Mar; 101:75-84. PMID: 23357284; PMCID: PMC3602403.
    9. Metherate R, Intskirveli I, Kawai HD. Nicotinic filtering of sensory processing in auditory cortex. Front Behav Neurosci. 2012; 6:44. PMID: 22833720; PMCID: PMC3400128.
    10. Intskirveli I, Metherate R. Nicotinic neuromodulation in auditory cortex requires MAPK activation in thalamocortical and intracortical circuits. J Neurophysiol. 2012 May; 107(10):2782-93. PMID: 22357798; PMCID: PMC3362282.
    11. Bieszczad KM, Kant R, Constantinescu CC, Pandey SK, Kawai HD, Metherate R, Weinberger NM, Mukherjee J. Nicotinic acetylcholine receptors in rat forebrain that bind ¹8F-nifene: relating PET imaging, autoradiography, and behavior. Synapse. 2012 May; 66(5):418-34. PMID: 22213342; PMCID: PMC3292694.
    12. Intskirveli I, Metherate R, Cramer KS. Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex. PLoS One. 2011; 6(10):e26192. PMID: 22022561; PMCID: PMC3192161.
    13. Kawai HD, Kang HA, Metherate R. Heightened nicotinic regulation of auditory cortex during adolescence. J Neurosci. 2011 Oct 05; 31(40):14367-77. PMID: 21976522; PMCID: PMC3210642.
    14. Metherate R. Functional connectivity and cholinergic modulation in auditory cortex. Neurosci Biobehav Rev. 2011 Nov; 35(10):2058-63. PMID: 21144860; PMCID: PMC3139107.
    15. Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. PMID: 19339596.
      View in: PubMed
    16. Liang K, Poytress BS, Weinberger NM, Metherate R. Nicotinic modulation of tone-evoked responses in auditory cortex reflects the strength of prior auditory learning. Neurobiol Learn Mem. 2008 Jul; 90(1):138-46. PMID: 18378471; PMCID: PMC2464281.
    17. Kawai H, Lazar R, Metherate R. Nicotinic control of axon excitability regulates thalamocortical transmission. Nat Neurosci. 2007 Sep; 10(9):1168-75. PMID: 17704774.
      View in: PubMed
    18. Liang K, Poytress BS, Chen Y, Leslie FM, Weinberger NM, Metherate R. Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats. Eur J Neurosci. 2006 Aug; 24(3):857-66. PMID: 16848798.
      View in: PubMed
    19. Metherate R, Kaur S, Kawai H, Lazar R, Liang K, Rose HJ. Spectral integration in auditory cortex: mechanisms and modulation. Hear Res. 2005 Aug; 206(1-2):146-58. PMID: 16081005.
      View in: PubMed
    20. Rose HJ, Metherate R. Auditory thalamocortical transmission is reliable and temporally precise. J Neurophysiol. 2005 Sep; 94(3):2019-30. PMID: 15928054.
      View in: PubMed
    21. Kaur S, Lazar R, Metherate R. Intracortical pathways determine breadth of subthreshold frequency receptive fields in primary auditory cortex. J Neurophysiol. 2004 Jun; 91(6):2551-67. PMID: 14749307.
      View in: PubMed
    22. Metherate R, Hsieh CY. Synaptic mechanisms and cholinergic regulation in auditory cortex. Prog Brain Res. 2004; 145:143-56. PMID: 14650913.
      View in: PubMed
    23. Metherate R. Nicotinic acetylcholine receptors in sensory cortex. Learn Mem. 2004 Jan-Feb; 11(1):50-9. PMID: 14747517.
      View in: PubMed
    24. Metherate R, Hsieh CY. Regulation of glutamate synapses by nicotinic acetylcholine receptors in auditory cortex. Neurobiol Learn Mem. 2003 Nov; 80(3):285-90. PMID: 14521870.
      View in: PubMed
    25. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21. PMID: 12895417.
      View in: PubMed
    26. Lazar R, Metherate R. Spectral interactions, but no mismatch negativity, in auditory cortex of anesthetized rat. Hear Res. 2003 Jul; 181(1-2):51-6. PMID: 12855362.
      View in: PubMed
    27. Hsieh CY, Chen Y, Leslie FM, Metherate R. Postnatal development of NR2A and NR2B mRNA expression in rat auditory cortex and thalamus. J Assoc Res Otolaryngol. 2002 Dec; 3(4):479-87. PMID: 12486601; PMCID: PMC3202444.
    28. Hsieh CY, Leslie FM, Metherate R. Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. Brain Res Dev Brain Res. 2002 Jan 31; 133(1):19-25. PMID: 11850060.
      View in: PubMed
    29. Cruikshank SJ, Rose HJ, Metherate R. Auditory thalamocortical synaptic transmission in vitro. J Neurophysiol. 2002 Jan; 87(1):361-84. PMID: 11784756.
      View in: PubMed
    30. Metherate R, Cruikshank SJ. Thalamocortical inputs trigger a propagating envelope of gamma-band activity in auditory cortex in vitro. Exp Brain Res. 1999 May; 126(2):160-74. PMID: 10369139.
      View in: PubMed
    31. Metherate R. Synaptic mechanisms in auditory cortex function. Front Biosci. 1998 May 06; 3:d494-501. PMID: 9569228.
      View in: PubMed