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Metherate, Raju

Title(s)Professor and Associate Dean of Undergraduate Education, Neurobiology & Behavior
Phone(949) 824-6141
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    Collapse Research 
    Collapse Research Activities and Funding
    Nicotinic enhancement of auditory-cognitive processing
    NIH/NIDCD R01DC017687Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Functions of Nicotine Receptors in Sensory Neocortex
    NIH/NIDCD R01DC013200Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Interdisciplinary Training Program in Hearing Research
    NIH/NIDCD T32DC010775Jul 1, 2010 - Jun 30, 2020
    Role: Principal Investigator
    UC Irvine Core Center for Hearing and Communication Research
    NIH/NIDCD P30DC008369Jul 1, 2006 - Mar 31, 2017
    Role: Principal Investigator
    Functions of Nicotine Receptors in Sensory Neocortex
    NIH/NIDA R01DA012929Jul 1, 2000 - Jul 30, 2013
    Role: Principal Investigator
    Cellular Mechanisms of Aditory Cortex Function
    NIH/NIDCD R01DC002967Sep 30, 1996 - Feb 28, 2009
    Role: Principal Investigator
    CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    NIH/NIDCD R29DC002967Sep 30, 1996 - Feb 28, 2003
    Role: Principal Investigator
    CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    NIH/NIDCD R55DC002967Sep 30, 1996 - Jun 30, 1997
    Role: Principal Investigator
    FUNCTION OF ACH IN AUDITORY CORTEX RESPONSE PLASTICITY
    NIH/NIDCD F32DC000002Mar 20, 1989
    Role: Principal Investigator
    FUNCTION OF ACH IN AUDITORY CORTEX RESPONSE PLASTICITY
    NIH/NINDS F32NS008001Oct 21, 1986
    Role: Principal Investigator
    THE ROLE OF ACETYLCHOLINE IN THE SOMATOSENSORY CORTEX
    NIH/NIMH F31MH008996Jun 1, 1983
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Askew CE, Lopez AJ, Wood MA, Metherate R. Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex. Synapse. 2019 May 13; e22116. PMID: 31081950.
      View in: PubMed
    2. Gil SM, Metherate R. Enhanced Sensory-Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors. Nicotine Tob Res. 2019 Feb 18; 21(3):377-382. PMID: 30137439.
      View in: PubMed
    3. Samra GK, Intskirveli I, Govind AP, Liang C, Lazar R, Green WN, Metherate R, Mukherjee J. Development of fluorescence imaging probes for nicotinic acetylcholine a4ß2* receptors. Bioorg Med Chem Lett. 2017 Dec 17. PMID: 29277457.
      View in: PubMed
    4. Mukherjee J, Lao PJ, Betthauser TJ, Samra GK, Pan ML, Patel IH, Liang C, Metherate R, Christian BT. Human brain imaging of nicotinic acetylcholine a4ß2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways. J Comp Neurol. 2018 Jan 01; 526(1):80-95. PMID: 28875553.
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    5. Askew C, Intskirveli I, Metherate R. Systemic Nicotine Increases Gain and Narrows Receptive Fields in A1 via Integrated Cortical and Subcortical Actions. eNeuro. 2017 May-Jun; 4(3). PMID: 28660244.
      View in: PubMed
    6. Intskirveli I, Joshi A, Vizcarra-Chacón BJ, Metherate R. Spectral breadth and laminar distribution of thalamocortical inputs to A1. J Neurophysiol. 2016 Apr; 115(4):2083-94. PMID: 26888102.
      View in: PubMed
    7. Askew CE, Metherate R. Synaptic interactions and inhibitory regulation in auditory cortex. Biol Psychol. 2016 Apr; 116:4-9. PMID: 26555718.
      View in: PubMed
    8. Kawai HD, La M, Kang HA, Hashimoto Y, Liang K, Lazar R, Metherate R. Convergence of nicotine-induced and auditory-evoked neural activity activates ERK in auditory cortex. Synapse. 2013 Aug; 67(8):455-68. PMID: 23401204.
      View in: PubMed
    9. Guo F, Intskirveli I, Blake DT, Metherate R. Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex. Neurobiol Learn Mem. 2013 Mar; 101:75-84. PMID: 23357284.
      View in: PubMed
    10. Metherate R, Intskirveli I, Kawai HD. Nicotinic filtering of sensory processing in auditory cortex. Front Behav Neurosci. 2012; 6:44. PMID: 22833720.
      View in: PubMed
    11. Intskirveli I, Metherate R. Nicotinic neuromodulation in auditory cortex requires MAPK activation in thalamocortical and intracortical circuits. J Neurophysiol. 2012 May; 107(10):2782-93. PMID: 22357798.
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    12. Bieszczad KM, Kant R, Constantinescu CC, Pandey SK, Kawai HD, Metherate R, Weinberger NM, Mukherjee J. Nicotinic acetylcholine receptors in rat forebrain that bind ¹8F-nifene: relating PET imaging, autoradiography, and behavior. Synapse. 2012 May; 66(5):418-34. PMID: 22213342.
      View in: PubMed
    13. Intskirveli I, Metherate R, Cramer KS. Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex. PLoS One. 2011; 6(10):e26192. PMID: 22022561.
      View in: PubMed
    14. Kawai HD, Kang HA, Metherate R. Heightened nicotinic regulation of auditory cortex during adolescence. J Neurosci. 2011 Oct 05; 31(40):14367-77. PMID: 21976522.
      View in: PubMed
    15. Metherate R. Functional connectivity and cholinergic modulation in auditory cortex. Neurosci Biobehav Rev. 2011 Nov; 35(10):2058-63. PMID: 21144860.
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    16. Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. PMID: 19339596.
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    17. Liang K, Poytress BS, Weinberger NM, Metherate R. Nicotinic modulation of tone-evoked responses in auditory cortex reflects the strength of prior auditory learning. Neurobiol Learn Mem. 2008 Jul; 90(1):138-46. PMID: 18378471.
      View in: PubMed
    18. Kawai H, Lazar R, Metherate R. Nicotinic control of axon excitability regulates thalamocortical transmission. Nat Neurosci. 2007 Sep; 10(9):1168-75. PMID: 17704774.
      View in: PubMed
    19. Liang K, Poytress BS, Chen Y, Leslie FM, Weinberger NM, Metherate R. Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats. Eur J Neurosci. 2006 Aug; 24(3):857-66. PMID: 16848798.
      View in: PubMed
    20. Metherate R, Kaur S, Kawai H, Lazar R, Liang K, Rose HJ. Spectral integration in auditory cortex: mechanisms and modulation. Hear Res. 2005 Aug; 206(1-2):146-58. PMID: 16081005.
      View in: PubMed
    21. Rose HJ, Metherate R. Auditory thalamocortical transmission is reliable and temporally precise. J Neurophysiol. 2005 Sep; 94(3):2019-30. PMID: 15928054.
      View in: PubMed
    22. Kaur S, Rose HJ, Lazar R, Liang K, Metherate R. Spectral integration in primary auditory cortex: laminar processing of afferent input, in vivo and in vitro. Neuroscience. 2005; 134(3):1033-45. PMID: 15979241.
      View in: PubMed
    23. Kaur S, Lazar R, Metherate R. Intracortical pathways determine breadth of subthreshold frequency receptive fields in primary auditory cortex. J Neurophysiol. 2004 Jun; 91(6):2551-67. PMID: 14749307.
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    24. Metherate R, Hsieh CY. Synaptic mechanisms and cholinergic regulation in auditory cortex. Prog Brain Res. 2004; 145:143-56. PMID: 14650913.
      View in: PubMed
    25. Metherate R. Nicotinic acetylcholine receptors in sensory cortex. Learn Mem. 2004 Jan-Feb; 11(1):50-9. PMID: 14747517.
      View in: PubMed
    26. Metherate R, Hsieh CY. Regulation of glutamate synapses by nicotinic acetylcholine receptors in auditory cortex. Neurobiol Learn Mem. 2003 Nov; 80(3):285-90. PMID: 14521870.
      View in: PubMed
    27. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21. PMID: 12895417.
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    28. Lazar R, Metherate R. Spectral interactions, but no mismatch negativity, in auditory cortex of anesthetized rat. Hear Res. 2003 Jul; 181(1-2):51-6. PMID: 12855362.
      View in: PubMed
    29. Hsieh CY, Chen Y, Leslie FM, Metherate R. Postnatal development of NR2A and NR2B mRNA expression in rat auditory cortex and thalamus. J Assoc Res Otolaryngol. 2002 Dec; 3(4):479-87. PMID: 12486601; PMCID: PMC3202444.
    30. Hsieh CY, Leslie FM, Metherate R. Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. Brain Res Dev Brain Res. 2002 Jan 31; 133(1):19-25. PMID: 11850060.
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    31. Cruikshank SJ, Rose HJ, Metherate R. Auditory thalamocortical synaptic transmission in vitro. J Neurophysiol. 2002 Jan; 87(1):361-84. PMID: 11784756.
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    32. Cruikshank SJ, Killackey HP, Metherate R. Parvalbumin and calbindin are differentially distributed within primary and secondary subregions of the mouse auditory forebrain. Neuroscience. 2001; 105(3):553-69. PMID: 11516823.
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    33. Rose HJ, Metherate R. Thalamic stimulation largely elicits orthodromic, rather than antidromic, cortical activation in an auditory thalamocortical slice. Neuroscience. 2001; 106(2):331-40. PMID: 11566504.
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    34. Hsieh CY, Cruikshank SJ, Metherate R. Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist. Brain Res. 2000 Oct 13; 880(1-2):51-64. PMID: 11032989.
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    35. Aramakis VB, Hsieh CY, Leslie FM, Metherate R. A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex. J Neurosci. 2000 Aug 15; 20(16):6106-16. PMID: 10934260.
      View in: PubMed
    36. Metherate R, Aramakis VB. Intrinsic electrophysiology of neurons in thalamorecipient layers of developing rat auditory cortex. Brain Res Dev Brain Res. 1999 Jun 02; 115(2):131-44. PMID: 10407131.
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    37. Metherate R, Cruikshank SJ. Thalamocortical inputs trigger a propagating envelope of gamma-band activity in auditory cortex in vitro. Exp Brain Res. 1999 May; 126(2):160-74. PMID: 10369139.
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    38. Aramakis VB, Metherate R. Nicotine selectively enhances NMDA receptor-mediated synaptic transmission during postnatal development in sensory neocortex. J Neurosci. 1998 Oct 15; 18(20):8485-95. PMID: 9763491.
      View in: PubMed
    39. Metherate R. Synaptic mechanisms in auditory cortex function. Front Biosci. 1998 May 06; 3:d494-501. PMID: 9569228.
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    40. Metherate R, Ashe JH, Weinberger NM. Acetylcholine modifies neuronal acoustic rate-level functions in guinea pig auditory cortex by an action at muscarinic receptors. Synapse. 1990; 6(4):364-8. PMID: 2287993.
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    41. Metherate R, Weinberger NM. Cholinergic modulation of responses to single tones produces tone-specific receptive field alterations in cat auditory cortex. Synapse. 1990; 6(2):133-45. PMID: 2237776.
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    42. Metherate R, Weinberger NM. Acetylcholine produces stimulus-specific receptive field alterations in cat auditory cortex. Brain Res. 1989 Feb 20; 480(1-2):372-7. PMID: 2713663.
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    43. Metherate RS, da Costa DC, Herron P, Dykes RW. A thalamic terminus of the lateral cervical nucleus: the lateral division of the posterior nuclear group. J Neurophysiol. 1986 Dec; 56(6):1498-520. PMID: 3027272.
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    44. Mabie CP, Menis DL, Whitenton EP, Trout RL, Metherate RS, Ferry CH. Gel route preparation of low fusing dental porcelain frit. J Biomed Mater Res. 1983 Jul; 17(4):691-713. PMID: 6309855.
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