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Todd C Holmes

Title(s)Professor, Physiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-0006
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    Collapse Research 
    Collapse Research Activities and Funding
    UV to blue neuronal phototransduction mechanisms
    NIH R35GM127102Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mechanism of cryptochrome-mediated photo transduction
    NIH R01GM102965Aug 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Ultraviolet light sensing by cryptochrome
    NIH R01GM107405Aug 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Electrical Signaling in a Circadian Pacemaker Circuit
    NIH R01NS046750Jul 1, 2003 - Dec 31, 2014
    Role: Principal Investigator
    Transgenic Electrical Silencing of a Neural Circuit
    NIH R21DA016352Sep 27, 2002 - Aug 31, 2005
    Role: Principal Investigator
    TYROSINE PHOSPHORYLATION OF ION CHANNELS
    NIH F32NS009990Apr 1, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Weekend light shifts evoke persistent Drosophila circadian neural network desynchrony. J Neurosci. 2021 Apr 30. Nave C, Roberts L, Hwu P, Estrella JD, Vo TC, Nguyen TH, Bui TT, Rindner DJ, Pervolarakis N, Shaw PJ, Leise TL, Holmes TC. PMID: 33931552.
      View in: PubMed   Mentions:    Fields:    
    2. Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine. Transl Psychiatry. 2021 Feb 24; 11(1):144. Grieco SF, Qiao X, Johnston KG, Chen L, Nelson RR, Lai C, Holmes TC, Xu X. PMID: 33627623.
      View in: PubMed   Mentions: 1     Fields:    
    3. Microglia elimination increases neural circuit connectivity and activity in adult mouse cortex. J Neurosci. 2020 Dec 23. Liu YJ, Spangenberg E, Tang B, Holmes TC, Green KN, Xu X. PMID: 33380470.
      View in: PubMed   Mentions:    Fields:    
    4. Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains. J Neurosci. 2020 10 14; 40(42):7999-8024. Ravenscroft TA, Janssens J, Lee PT, Tepe B, Marcogliese PC, Makhzami S, Holmes TC, Aerts S, Bellen HJ. PMID: 32928889.
      View in: PubMed   Mentions:    Fields:    
    5. Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia. Curr Biol. 2020 Sep 21; 30(18):3591-3603.e8. Grieco SF, Qiao X, Zheng X, Liu Y, Chen L, Zhang H, Yu Z, Gavornik JP, Lai C, Gandhi SP, Holmes TC, Xu X. PMID: 32822611.
      View in: PubMed   Mentions:    Fields:    
    6. Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers. Neuron. 2020 09 23; 107(6):1029-1047. Xu X, Holmes TC, Luo MH, Beier KT, Horwitz GD, Zhao F, Zeng W, Hui M, Semler BL, Sandri-Goldin RM. PMID: 32755550.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Circadian Regulation of Light-Evoked Attraction and Avoidance Behaviors in Daytime- versus Nighttime-Biting Mosquitoes. Curr Biol. 2020 Aug 17; 30(16):3252-3259.e3. Baik LS, Nave C, Au DD, Guda T, Chevez JA, Ray A, Holmes TC. PMID: 32619483.
      View in: PubMed   Mentions:    Fields:    
    8. Fos-CreER-based genetic mapping of forebrain regions activated by acupuncture. J Comp Neurol. 2020 Apr; 528(6):953-971. Guo Z, Lin X, Samaniego T, Isreb A, Cao S, Malik S, Holmes TC, Xu X. PMID: 31600836.
      View in: PubMed   Mentions: 1     Fields:    
    9. Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23339-23344. Baik LS, Au DD, Nave C, Foden AJ, Enrriquez-Villalva WK, Holmes TC. PMID: 31659046.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro. 2019 Sep/Oct; 6(5). Gong N, Hagopian G, Holmes TC, Luo ZD, Xu X. PMID: 31533959.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    11. CA1-projecting subiculum neurons facilitate object-place learning. Nat Neurosci. 2019 11; 22(11):1857-1870. Sun Y, Jin S, Lin X, Chen L, Qiao X, Jiang L, Zhou P, Johnston KG, Golshani P, Nie Q, Holmes TC, Nitz DA, Xu X. PMID: 31548723.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. J Comp Neurol. 2020 02 15; 528(3):419-432. Grieco SF, Wang G, Mahapatra A, Lai C, Holmes TC, Xu X. PMID: 31454079.
      View in: PubMed   Mentions:    Fields:    
    13. Multiple Phototransduction Inputs Integrate to Mediate UV Light-evoked Avoidance/Attraction Behavior in Drosophila. J Biol Rhythms. 2019 08; 34(4):391-400. Baik LS, Recinos Y, Chevez JA, Au DD, Holmes TC. PMID: 31140349.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Development of Local Circuit Connections to Hilar Mossy Cells in the Mouse Dentate Gyrus. eNeuro. 2019 Mar-Apr; 6(2). Shi Y, Grieco SF, Holmes TC, Xu X. PMID: 30937358.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Circadian modulation of light-evoked avoidance/attraction behavior in Drosophila. PLoS One. 2018; 13(8):e0201927. Baik LS, Recinos Y, Chevez JA, Holmes TC. PMID: 30106957.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Neuregulin directed molecular mechanisms of visual cortical plasticity. J Comp Neurol. 2019 02 15; 527(3):668-678. Grieco SF, Holmes TC, Xu X. PMID: 29464684.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. Opposing and Complementary Topographic Connectivity Gradients Revealed by Quantitative Analysis of Canonical and Noncanonical Hippocampal CA1 Inputs. eNeuro. 2018 Jan-Feb; 5(1). Sun Y, Nitz DA, Holmes TC, Xu X. PMID: 29387780.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    18. A rhodopsin in the brain functions in circadian photoentrainment in Drosophila. Nature. 2017 05 18; 545(7654):340-344. Ni JD, Baik LS, Holmes TC, Montell C. PMID: 28489826.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    19. Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus. eNeuro. 2017 Mar-Apr; 4(2). Sun Y, Grieco SF, Holmes TC, Xu X. PMID: 28451637.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. CRYPTOCHROME mediates behavioral executive choice in response to UV light. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):776-781. Baik LS, Fogle KJ, Roberts L, Galschiodt AM, Chevez JA, Recinos Y, Nguy V, Holmes TC. PMID: 28062690.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    21. Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells. Genes Dev. 2016 12 01; 30(23):2596-2606. Barber AF, Erion R, Holmes TC, Sehgal A. PMID: 27979876.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron. 2016 Oct 05; 92(1):160-173. Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X. PMID: 27641496.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    23. Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics. J Biol Rhythms. 2016 08; 31(4):337-51. Roberts L, Leise TL, Welsh DK, Holmes TC. PMID: 27221103.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Noncanonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016 12 01; 524(17):3666-3673. Xu X, Sun Y, Holmes TC, López AJ. PMID: 27150503.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    25. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory vs. strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016 06 01; 115(6):3204-16. Xu X, Ikrar T, Sun Y, Santos R, Holmes TC, Francesconi W, Berton F. PMID: 27052587.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 01; 594(7):1891-910. Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. PMID: 26844927.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster. J Biol Rhythms. 2016 06; 31(3):272-88. Das A, Holmes TC, Sheeba V. PMID: 26868037.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    28. Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2016 08 15; 524(12):2379-99. Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. PMID: 26718312.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    29. dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster. PLoS One. 2015; 10(7):e0134213. Das A, Holmes TC, Sheeba V. PMID: 26226013.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    30. Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony. Curr Biol. 2015 Mar 30; 25(7):858-67. Roberts L, Leise TL, Noguchi T, Galschiodt AM, Houl JH, Welsh DK, Holmes TC. PMID: 25754644.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel ß-subunit redox sensor. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2245-50. Fogle KJ, Baik LS, Houl JH, Tran TT, Roberts L, Dahm NA, Cao Y, Zhou M, Holmes TC. PMID: 25646452.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    32. Insect circadian clock outputs. Essays Biochem. 2011 Jun 30; 49(1):87-101. Helfrich-Förster C, Nitabach MN, Holmes TC. PMID: 21819386.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    33. CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science. 2011 Mar 18; 331(6023):1409-13. Fogle KJ, Parson KG, Dahm NA, Holmes TC. PMID: 21385718.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    34. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS One. 2010 Jul 16; 5(7):e11628. Sheeba V, Fogle KJ, Holmes TC. PMID: 20661292.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    35. Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol. 2008 Oct 28; 18(20):1537-45. Sheeba V, Fogle KJ, Kaneko M, Rashid S, Chou YT, Sharma VK, Holmes TC. PMID: 18771923.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    36. Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci. 2008 Jun 04; 28(23):6010-21. Ayaz D, Leyssen M, Koch M, Yan J, Srahna M, Sheeba V, Fogle KJ, Holmes TC, Hassan BA. PMID: 18524906.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    37. Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 2008 Jan 02; 28(1):217-27. Sheeba V, Sharma VK, Gu H, Chou YT, O'Dowd DK, Holmes TC. PMID: 18171939.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    38. The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella? Crit Rev Biochem Mol Biol. 2008 Jan-Feb; 43(1):37-61. Sheeba V, Kaneko M, Sharma VK, Holmes TC. PMID: 18307108.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    39. Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol. 2008 Feb; 99(2):976-88. Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC. PMID: 18077664.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    40. Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci. 2006 Jan 11; 26(2):479-89. Nitabach MN, Wu Y, Sheeba V, Lemon WC, Strumbos J, Zelensky PK, White BH, Holmes TC. PMID: 16407545.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    41. Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J Neurosci. 2006 Jan 11; 26(2):573-84. Luan H, Lemon WC, Peabody NC, Pohl JB, Zelensky PK, Wang D, Nitabach MN, Holmes TC, White BH. PMID: 16407556.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    42. Circadian pathway: the other shoe drops. Curr Biol. 2005 Dec 20; 15(24):R987-9. Holmes TC, Sheeba V. PMID: 16360675.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    43. Membrane electrical excitability is necessary for the free-running larval Drosophila circadian clock. J Neurobiol. 2005 Jan; 62(1):1-13. Nitabach MN, Sheeba V, Vera DA, Blau J, Holmes TC. PMID: 15389695.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    44. Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator. Methods Enzymol. 2005; 393:682-93. Nitabach MN, Holmes TC, Blau J. PMID: 15817319.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    45. The end of single-molecule envy. Chem Biol. 2005 Jan; 12(1):8-10. Holmes TC. PMID: 15664509.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    46. Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases. J Neurosci. 2002 Sep 15; 22(18):7913-22. Nitabach MN, Llamas DA, Thompson IJ, Collins KA, Holmes TC. PMID: 12223544.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    47. Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana. Mol Biol Evol. 2002 Jul; 19(7):1066-82. Chiu JC, Brenner ED, DeSalle R, Nitabach MN, Holmes TC, Coruzzi GM. PMID: 12082126.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    48. Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell. 2002 May 17; 109(4):485-95. Nitabach MN, Blau J, Holmes TC. PMID: 12086605.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    49. Ion channel-directed therapies in autonomic neurons: a view from the bench. Clin Auton Res. 2002 Apr; 12(2):59-65. Holmes TC. PMID: 12102451.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    50. Novel peptide-based biomaterial scaffolds for tissue engineering. Trends Biotechnol. 2002 Jan; 20(1):16-21. Holmes TC. PMID: 11742673.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    51. Is the molecular composition of K(ATP) channels more complex than originally thought? J Mol Cell Cardiol. 2001 Aug; 33(8):1541-6. Pountney DJ, Sun ZQ, Porter LM, Nitabach MN, Nakamura TY, Holmes D, Rosner E, Kaneko M, Manaris T, Holmes TC, Coetzee WA. PMID: 11448141.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    52. A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):705-10. Nitabach MN, Llamas DA, Araneda RC, Intile JL, Thompson IJ, Zhou YI, Holmes TC. PMID: 11149959.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    53. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6728-33. Holmes TC, de Lacalle S, Su X, Liu G, Rich A, Zhang S. PMID: 10841570.
      View in: PubMed   Mentions: 182     Fields:    Translation:AnimalsCells
    54. Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation. J Neurosci. 1997 Dec 01; 17(23):8964-74. Holmes TC, Berman K, Swartz JE, Dagan D, Levitan IB. PMID: 9364044.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    55. Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J Gen Physiol. 1997 Nov; 110(5):601-10. Bowlby MR, Fadool DA, Holmes TC, Levitan IB. PMID: 9348331.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    56. Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol. 1997 Sep; 78(3):1563-73. Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB. PMID: 9310443.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    57. Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science. 1996 Dec 20; 274(5295):2089-91. Holmes TC, Fadool DA, Ren R, Levitan IB. PMID: 8953041.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    58. Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci. 1996 Mar 01; 16(5):1581-90. Holmes TC, Fadool DA, Levitan IB. PMID: 8774427.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    59. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials. 1995 Dec; 16(18):1385-93. Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A. PMID: 8590765.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
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