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Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons. Cell Rep. 2022 May 10; 39(6):110787.
Morioka E, Kasuga Y, Kanda Y, Moritama S, Koizumi H, Yoshikawa T, Miura N, Ikeda M, Higashida H, Holmes TC, Ikeda M. PMID: 35545046.
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Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain? Neurosci Insights. 2022; 17:26331055211071124.
Liu YJ, Green KN, Holmes TC, Xu X. PMID: 35098130; PMCID: PMC8796061.
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Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway. PLoS Biol. 2021 12; 19(12):e3001127.
Lin X, Amalraj M, Blanton C, Avila B, Holmes TC, Nitz DA, Xu X. PMID: 34928938; PMCID: PMC8741299.
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Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model. Neurobiol Dis. 2022 01; 162:105562.
Lin X, Chen L, Baglietto-Vargas D, Kamalipour P, Ye Q, LaFerla FM, Nitz DA, Holmes TC, Xu X. PMID: 34838667.
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Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research. Neuron. 2022 01 05; 110(1):21-35.
Yu Z, Guindani M, Grieco SF, Chen L, Holmes TC, Xu X. PMID: 34784504; PMCID: PMC8763600.
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PubMed Mentions:
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Weekend Light Shifts Evoke Persistent Drosophila Circadian Neural Network Desynchrony. J Neurosci. 2021 06 16; 41(24):5173-5189.
Nave C, Roberts L, Hwu P, Estrella JD, Vo TC, Nguyen TH, Bui TT, Rindner DJ, Pervolarakis N, Shaw PJ, Leise TL, Holmes TC. PMID: 33931552; PMCID: PMC8211545.
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PubMed Mentions: Fields:
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Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine. Transl Psychiatry. 2021 02 24; 11(1):144.
Grieco SF, Qiao X, Johnston KG, Chen L, Nelson RR, Lai C, Holmes TC, Xu X. PMID: 33627623; PMCID: PMC7904825.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Microglia Elimination Increases Neural Circuit Connectivity and Activity in Adult Mouse Cortex. J Neurosci. 2021 02 10; 41(6):1274-1287.
Liu YJ, Spangenberg EE, Tang B, Holmes TC, Green KN, Xu X. PMID: 33380470; PMCID: PMC7888230.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains. J Neurosci. 2020 10 14; 40(42):7999-8024.
Ravenscroft TA, Janssens J, Lee PT, Tepe B, Marcogliese PC, Makhzami S, Holmes TC, Aerts S, Bellen HJ. PMID: 32928889; PMCID: PMC7574647.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia. Curr Biol. 2020 09 21; 30(18):3591-3603.e8.
Grieco SF, Qiao X, Zheng X, Liu Y, Chen L, Zhang H, Yu Z, Gavornik JP, Lai C, Gandhi SP, Holmes TC, Xu X. PMID: 32822611; PMCID: PMC7925140.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers. Neuron. 2020 09 23; 107(6):1029-1047.
Xu X, Holmes TC, Luo MH, Beier KT, Horwitz GD, Zhao F, Zeng W, Hui M, Semler BL, Sandri-Goldin RM. PMID: 32755550; PMCID: PMC7530073.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Circadian Regulation of Light-Evoked Attraction and Avoidance Behaviors in Daytime- versus Nighttime-Biting Mosquitoes. Curr Biol. 2020 08 17; 30(16):3252-3259.e3.
Baik LS, Nave C, Au DD, Guda T, Chevez JA, Ray A, Holmes TC. PMID: 32619483; PMCID: PMC7438308.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Fos-CreER-based genetic mapping of forebrain regions activated by acupuncture. J Comp Neurol. 2020 04; 528(6):953-971.
Guo Z, Lin X, Samaniego T, Isreb A, Cao S, Malik S, Holmes TC, Xu X. PMID: 31600836; PMCID: PMC7774513.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23339-23344.
Baik LS, Au DD, Nave C, Foden AJ, Enrriquez-Villalva WK, Holmes TC. PMID: 31659046; PMCID: PMC6859314.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro. 2019 Sep/Oct; 6(5).
Gong N, Hagopian G, Holmes TC, Luo ZD, Xu X. PMID: 31533959; PMCID: PMC6787342.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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CA1-projecting subiculum neurons facilitate object-place learning. Nat Neurosci. 2019 11; 22(11):1857-1870.
Sun Y, Jin S, Lin X, Chen L, Qiao X, Jiang L, Zhou P, Johnston KG, Golshani P, Nie Q, Holmes TC, Nitz DA, Xu X. PMID: 31548723; PMCID: PMC6819262.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. J Comp Neurol. 2020 02 15; 528(3):419-432.
Grieco SF, Wang G, Mahapatra A, Lai C, Holmes TC, Xu X. PMID: 31454079; PMCID: PMC6901715.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Multiple Phototransduction Inputs Integrate to Mediate UV Light-evoked Avoidance/Attraction Behavior in Drosophila. J Biol Rhythms. 2019 08; 34(4):391-400.
Baik LS, Recinos Y, Chevez JA, Au DD, Holmes TC. PMID: 31140349; PMCID: PMC7118705.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Development of Local Circuit Connections to Hilar Mossy Cells in the Mouse Dentate Gyrus. eNeuro. 2019 Mar-Apr; 6(2).
Shi Y, Grieco SF, Holmes TC, Xu X. PMID: 30937358; PMCID: PMC6439204.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Circadian modulation of light-evoked avoidance/attraction behavior in Drosophila. PLoS One. 2018; 13(8):e0201927.
Baik LS, Recinos Y, Chevez JA, Holmes TC. PMID: 30106957; PMCID: PMC6091921.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Neuregulin directed molecular mechanisms of visual cortical plasticity. J Comp Neurol. 2019 02 15; 527(3):668-678.
Grieco SF, Holmes TC, Xu X. PMID: 29464684; PMCID: PMC6103898.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Opposing and Complementary Topographic Connectivity Gradients Revealed by Quantitative Analysis of Canonical and Noncanonical Hippocampal CA1 Inputs. eNeuro. 2018 Jan-Feb; 5(1).
Sun Y, Nitz DA, Holmes TC, Xu X. PMID: 29387780; PMCID: PMC5790753.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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A rhodopsin in the brain functions in circadian photoentrainment in Drosophila. Nature. 2017 05 18; 545(7654):340-344.
Ni JD, Baik LS, Holmes TC, Montell C. PMID: 28489826; PMCID: PMC5476302.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus. eNeuro. 2017 Mar-Apr; 4(2).
Sun Y, Grieco SF, Holmes TC, Xu X. PMID: 28451637; PMCID: PMC5396130.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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CRYPTOCHROME mediates behavioral executive choice in response to UV light. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):776-781.
Baik LS, Fogle KJ, Roberts L, Galschiodt AM, Chevez JA, Recinos Y, Nguy V, Holmes TC. PMID: 28062690; PMCID: PMC5278478.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells. Genes Dev. 2016 12 01; 30(23):2596-2606.
Barber AF, Erion R, Holmes TC, Sehgal A. PMID: 27979876; PMCID: PMC5204352.
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PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron. 2016 Oct 05; 92(1):160-173.
Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X. PMID: 27641496; PMCID: PMC5310354.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics. J Biol Rhythms. 2016 08; 31(4):337-51.
Roberts L, Leise TL, Welsh DK, Holmes TC. PMID: 27221103.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Noncanonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016 12 01; 524(17):3666-3673.
Xu X, Sun Y, Holmes TC, López AJ. PMID: 27150503; PMCID: PMC5050062.
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PubMed Mentions:
15 Fields:
Translation:
Animals
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High-resolution and cell-type-specific photostimulation mapping shows weak excitatory vs. strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016 06 01; 115(6):3204-16.
Xu X, Ikrar T, Sun Y, Santos R, Holmes TC, Francesconi W, Berton F. PMID: 27052587; PMCID: PMC4946595.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 01; 594(7):1891-910.
Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. PMID: 26844927; PMCID: PMC4818606.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster. J Biol Rhythms. 2016 06; 31(3):272-88.
Das A, Holmes TC, Sheeba V. PMID: 26868037.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2016 08 15; 524(12):2379-99.
Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. PMID: 26718312; PMCID: PMC5359980.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster. PLoS One. 2015; 10(7):e0134213.
Das A, Holmes TC, Sheeba V. PMID: 26226013; PMCID: PMC4520709.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony. Curr Biol. 2015 Mar 30; 25(7):858-67.
Roberts L, Leise TL, Noguchi T, Galschiodt AM, Houl JH, Welsh DK, Holmes TC. PMID: 25754644; PMCID: PMC4399721.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2245-50.
Fogle KJ, Baik LS, Houl JH, Tran TT, Roberts L, Dahm NA, Cao Y, Zhou M, Holmes TC. PMID: 25646452; PMCID: PMC4343116.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Insect circadian clock outputs. Essays Biochem. 2011 Jun 30; 49(1):87-101.
Helfrich-Förster C, Nitabach MN, Holmes TC. PMID: 21819386.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science. 2011 Mar 18; 331(6023):1409-13.
Fogle KJ, Parson KG, Dahm NA, Holmes TC. PMID: 21385718; PMCID: PMC4418525.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS One. 2010 Jul 16; 5(7):e11628.
Sheeba V, Fogle KJ, Holmes TC. PMID: 20661292; PMCID: PMC2905440.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol. 2008 Oct 28; 18(20):1537-45.
Sheeba V, Fogle KJ, Kaneko M, Rashid S, Chou YT, Sharma VK, Holmes TC. PMID: 18771923; PMCID: PMC2597195.
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PubMed Mentions:
134 Fields:
Translation:
AnimalsCells
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Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci. 2008 Jun 04; 28(23):6010-21.
Ayaz D, Leyssen M, Koch M, Yan J, Srahna M, Sheeba V, Fogle KJ, Holmes TC, Hassan BA. PMID: 18524906; PMCID: PMC2693324.
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PubMed Mentions:
50 Fields:
Translation:
AnimalsCells
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Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 2008 Jan 02; 28(1):217-27.
Sheeba V, Sharma VK, Gu H, Chou YT, O'Dowd DK, Holmes TC. PMID: 18171939; PMCID: PMC2692917.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella? Crit Rev Biochem Mol Biol. 2008 Jan-Feb; 43(1):37-61.
Sheeba V, Kaneko M, Sharma VK, Holmes TC. PMID: 18307108; PMCID: PMC2597196.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol. 2008 Feb; 99(2):976-88.
Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC. PMID: 18077664; PMCID: PMC2692874.
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PubMed Mentions:
103 Fields:
Translation:
AnimalsCells
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Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci. 2006 Jan 11; 26(2):479-89.
Nitabach MN, Wu Y, Sheeba V, Lemon WC, Strumbos J, Zelensky PK, White BH, Holmes TC. PMID: 16407545; PMCID: PMC2597197.
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PubMed Mentions:
142 Fields:
Translation:
AnimalsCells
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Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J Neurosci. 2006 Jan 11; 26(2):573-84.
Luan H, Lemon WC, Peabody NC, Pohl JB, Zelensky PK, Wang D, Nitabach MN, Holmes TC, White BH. PMID: 16407556; PMCID: PMC1857274.
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PubMed Mentions:
88 Fields:
Translation:
AnimalsCells
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Circadian pathway: the other shoe drops. Curr Biol. 2005 Dec 20; 15(24):R987-9.
Holmes TC, Sheeba V. PMID: 16360675.
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AnimalsCells
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Membrane electrical excitability is necessary for the free-running larval Drosophila circadian clock. J Neurobiol. 2005 Jan; 62(1):1-13.
Nitabach MN, Sheeba V, Vera DA, Blau J, Holmes TC. PMID: 15389695.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator. Methods Enzymol. 2005; 393:682-93.
Nitabach MN, Holmes TC, Blau J. PMID: 15817319.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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The end of single-molecule envy. Chem Biol. 2005 Jan; 12(1):8-10.
Holmes TC. PMID: 15664509.
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PubMed Mentions: Fields:
Translation:
Cells
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Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases. J Neurosci. 2002 Sep 15; 22(18):7913-22.
Nitabach MN, Llamas DA, Thompson IJ, Collins KA, Holmes TC. PMID: 12223544; PMCID: PMC6758110.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana. Mol Biol Evol. 2002 Jul; 19(7):1066-82.
Chiu JC, Brenner ED, DeSalle R, Nitabach MN, Holmes TC, Coruzzi GM. PMID: 12082126.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell. 2002 May 17; 109(4):485-95.
Nitabach MN, Blau J, Holmes TC. PMID: 12086605.
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PubMed Mentions:
174 Fields:
Translation:
AnimalsCells
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Ion channel-directed therapies in autonomic neurons: a view from the bench. Clin Auton Res. 2002 Apr; 12(2):59-65.
Holmes TC. PMID: 12102451.
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HumansAnimalsCells
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Novel peptide-based biomaterial scaffolds for tissue engineering. Trends Biotechnol. 2002 Jan; 20(1):16-21.
Holmes TC. PMID: 11742673.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Is the molecular composition of K(ATP) channels more complex than originally thought? J Mol Cell Cardiol. 2001 Aug; 33(8):1541-6.
Pountney DJ, Sun ZQ, Porter LM, Nitabach MN, Nakamura TY, Holmes D, Rosner E, Kaneko M, Manaris T, Holmes TC, Coetzee WA. PMID: 11448141.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):705-10.
Nitabach MN, Llamas DA, Araneda RC, Intile JL, Thompson IJ, Zhou YI, Holmes TC. PMID: 11149959; PMCID: PMC14652.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6728-33.
Holmes TC, de Lacalle S, Su X, Liu G, Rich A, Zhang S. PMID: 10841570; PMCID: PMC18719.
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PubMed Mentions:
189 Fields:
Translation:
AnimalsCells
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Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation. J Neurosci. 1997 Dec 01; 17(23):8964-74.
Holmes TC, Berman K, Swartz JE, Dagan D, Levitan IB. PMID: 9364044; PMCID: PMC6573616.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J Gen Physiol. 1997 Nov; 110(5):601-10.
Bowlby MR, Fadool DA, Holmes TC, Levitan IB. PMID: 9348331; PMCID: PMC2229388.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol. 1997 Sep; 78(3):1563-73.
Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB. PMID: 9310443.
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PubMed Mentions:
38 Fields:
Translation:
HumansCells
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Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science. 1996 Dec 20; 274(5295):2089-91.
Holmes TC, Fadool DA, Ren R, Levitan IB. PMID: 8953041.
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PubMed Mentions:
74 Fields:
Translation:
HumansCells
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Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci. 1996 Mar 01; 16(5):1581-90.
Holmes TC, Fadool DA, Levitan IB. PMID: 8774427; PMCID: PMC6578669.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
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Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials. 1995 Dec; 16(18):1385-93.
Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A. PMID: 8590765.
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PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells