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Holmes, Todd C

Title(s)Professor, Physiology and Biophysics
Phone(949) 824-0006
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    Collapse Research Activities and Funding
    UV to blue neuronal phototransduction mechanisms
    NIH/NIGMS R35GM127102Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mechanism of cryptochrome-mediated photo transduction
    NIH/NIGMS R01GM102965Aug 1, 2013 - May 31, 2017
    Role: Principal Investigator
    Ultraviolet light sensing by cryptochrome
    NIH/NIGMS R01GM107405Aug 1, 2013 - May 31, 2017
    Role: Principal Investigator
    Electrical Signaling in a Circadian Pacemaker Circuit
    NIH/NINDS R01NS046750Jul 1, 2003 - Dec 31, 2014
    Role: Principal Investigator
    Transgenic Electrical Silencing of a Neural Circuit
    NIH/NIDA R21DA016352Sep 27, 2002 - Aug 31, 2005
    Role: Principal Investigator
    TYROSINE PHOSPHORYLATION OF ION CHANNELS
    NIH/NINDS F32NS009990Apr 1, 1996
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baik LS, Recinos Y, Chevez JA, Holmes TC. Circadian modulation of light-evoked avoidance/attraction behavior in Drosophila. PLoS One. 2018; 13(8):e0201927. PMID: 30106957.
      View in: PubMed
    2. Grieco SF, Holmes TC, Xu X. Neuregulin directed molecular mechanisms of visual cortical plasticity. J Comp Neurol. 2019 Feb 15; 527(3):668-678. PMID: 29464684.
      View in: PubMed
    3. Sun Y, Nitz DA, Holmes TC, Xu X. Opposing and Complementary Topographic Connectivity Gradients Revealed by Quantitative Analysis of Canonical and Noncanonical Hippocampal CA1 Inputs. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29387780.
      View in: PubMed
    4. Ni JD, Baik LS, Holmes TC, Montell C. A rhodopsin in the brain functions in circadian photoentrainment in Drosophila. Nature. 2017 05 18; 545(7654):340-344. PMID: 28489826.
      View in: PubMed
    5. Sun Y, Grieco SF, Holmes TC, Xu X. Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus. eNeuro. 2017 Mar-Apr; 4(2). PMID: 28451637.
      View in: PubMed
    6. Baik LS, Fogle KJ, Roberts L, Galschiodt AM, Chevez JA, Recinos Y, Nguy V, Holmes TC. CRYPTOCHROME mediates behavioral executive choice in response to UV light. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):776-781. PMID: 28062690.
      View in: PubMed
    7. Barber AF, Erion R, Holmes TC, Sehgal A. Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells. Genes Dev. 2016 12 01; 30(23):2596-2606. PMID: 27979876.
      View in: PubMed
    8. Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X. Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron. 2016 Oct 05; 92(1):160-173. PMID: 27641496.
      View in: PubMed
    9. Roberts L, Leise TL, Welsh DK, Holmes TC. Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics. J Biol Rhythms. 2016 08; 31(4):337-51. PMID: 27221103.
      View in: PubMed
    10. Xu X, Sun Y, Holmes TC, López AJ. Noncanonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016 12 01; 524(17):3666-3673. PMID: 27150503.
      View in: PubMed
    11. Xu X, Ikrar T, Sun Y, Santos R, Holmes TC, Francesconi W, Berton F. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory vs. strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016 06 01; 115(6):3204-16. PMID: 27052587.
      View in: PubMed
    12. Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 01; 594(7):1891-910. PMID: 26844927; PMCID: PMC4818606 [Available on 04/01/17].
      View in: PubMed, PubMed Central
    13. Das A, Holmes TC, Sheeba V. dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster. J Biol Rhythms. 2016 06; 31(3):272-88. PMID: 26868037.
      View in: PubMed
    14. Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2016 08 15; 524(12):2379-99. PMID: 26718312.
      View in: PubMed
    15. Das A, Holmes TC, Sheeba V. dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster. PLoS One. 2015; 10(7):e0134213. PMID: 26226013; PMCID: PMC4520709.
      View in: PubMed, PubMed Central
    16. Roberts L, Leise TL, Noguchi T, Galschiodt AM, Houl JH, Welsh DK, Holmes TC. Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony. Curr Biol. 2015 Mar 30; 25(7):858-67. PMID: 25754644; PMCID: PMC4399721.
      View in: PubMed, PubMed Central
    17. Fogle KJ, Baik LS, Houl JH, Tran TT, Roberts L, Dahm NA, Cao Y, Zhou M, Holmes TC. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel ß-subunit redox sensor. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2245-50. PMID: 25646452; PMCID: PMC4343116.
      View in: PubMed, PubMed Central
    18. Helfrich-Förster C, Nitabach MN, Holmes TC. Insect circadian clock outputs. Essays Biochem. 2011 Jun 30; 49(1):87-101. PMID: 21819386.
      View in: PubMed
    19. Fogle KJ, Parson KG, Dahm NA, Holmes TC. CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science. 2011 Mar 18; 331(6023):1409-13. PMID: 21385718; PMCID: PMC4418525.
      View in: PubMed, PubMed Central
    20. Sheeba V, Fogle KJ, Holmes TC. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS One. 2010 Jul 16; 5(7):e11628. PMID: 20661292; PMCID: PMC2905440.
      View in: PubMed, PubMed Central
    21. Sheeba V, Fogle KJ, Kaneko M, Rashid S, Chou YT, Sharma VK, Holmes TC. Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol. 2008 Oct 28; 18(20):1537-45. PMID: 18771923; PMCID: PMC2597195.
      View in: PubMed, PubMed Central
    22. Ayaz D, Leyssen M, Koch M, Yan J, Srahna M, Sheeba V, Fogle KJ, Holmes TC, Hassan BA. Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci. 2008 Jun 04; 28(23):6010-21. PMID: 18524906; PMCID: PMC2693324.
      View in: PubMed, PubMed Central
    23. Sheeba V, Sharma VK, Gu H, Chou YT, O'Dowd DK, Holmes TC. Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 2008 Jan 02; 28(1):217-27. PMID: 18171939; PMCID: PMC2692917.
      View in: PubMed, PubMed Central
    24. Sheeba V, Kaneko M, Sharma VK, Holmes TC. The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella? Crit Rev Biochem Mol Biol. 2008 Jan-Feb; 43(1):37-61. PMID: 18307108; PMCID: PMC2597196.
      View in: PubMed, PubMed Central
    25. Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC. Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol. 2008 Feb; 99(2):976-88. PMID: 18077664; PMCID: PMC2692874.
      View in: PubMed, PubMed Central
    26. Nitabach MN, Wu Y, Sheeba V, Lemon WC, Strumbos J, Zelensky PK, White BH, Holmes TC. Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci. 2006 Jan 11; 26(2):479-89. PMID: 16407545; PMCID: PMC2597197.
      View in: PubMed, PubMed Central
    27. Luan H, Lemon WC, Peabody NC, Pohl JB, Zelensky PK, Wang D, Nitabach MN, Holmes TC, White BH. Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J Neurosci. 2006 Jan 11; 26(2):573-84. PMID: 16407556; PMCID: PMC1857274.
      View in: PubMed, PubMed Central
    28. Holmes TC, Sheeba V. Circadian pathway: the other shoe drops. Curr Biol. 2005 Dec 20; 15(24):R987-9. PMID: 16360675.
      View in: PubMed
    29. Holmes TC. The end of single-molecule envy. Chem Biol. 2005 Jan; 12(1):8-10. PMID: 15664509.
      View in: PubMed
    30. Nitabach MN, Holmes TC, Blau J. Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator. Methods Enzymol. 2005; 393:682-93. PMID: 15817319.
      View in: PubMed
    31. Nitabach MN, Sheeba V, Vera DA, Blau J, Holmes TC. Membrane electrical excitability is necessary for the free-running larval Drosophila circadian clock. J Neurobiol. 2005 Jan; 62(1):1-13. PMID: 15389695.
      View in: PubMed
    32. Nitabach MN, Llamas DA, Thompson IJ, Collins KA, Holmes TC. Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases. J Neurosci. 2002 Sep 15; 22(18):7913-22. PMID: 12223544.
      View in: PubMed
    33. Chiu JC, Brenner ED, DeSalle R, Nitabach MN, Holmes TC, Coruzzi GM. Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana. Mol Biol Evol. 2002 Jul; 19(7):1066-82. PMID: 12082126.
      View in: PubMed
    34. Nitabach MN, Blau J, Holmes TC. Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell. 2002 May 17; 109(4):485-95. PMID: 12086605.
      View in: PubMed
    35. Holmes TC. Ion channel-directed therapies in autonomic neurons: a view from the bench. Clin Auton Res. 2002 Apr; 12(2):59-65. PMID: 12102451.
      View in: PubMed
    36. Holmes TC. Novel peptide-based biomaterial scaffolds for tissue engineering. Trends Biotechnol. 2002 Jan; 20(1):16-21. PMID: 11742673.
      View in: PubMed
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