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Todd C Holmes

Title(s)Professor, Physiology and Biophysics
Phone(949) 824-0006
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    Collapse Research Activities and Funding
    UV to blue neuronal phototransduction mechanisms
    NIH/NIGMS R35GM127102Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mechanism of cryptochrome-mediated photo transduction
    NIH/NIGMS R01GM102965Aug 1, 2013 - May 31, 2017
    Role: Principal Investigator
    Ultraviolet light sensing by cryptochrome
    NIH/NIGMS R01GM107405Aug 1, 2013 - May 31, 2017
    Role: Principal Investigator
    Electrical Signaling in a Circadian Pacemaker Circuit
    NIH/NINDS R01NS046750Jul 1, 2003 - Dec 31, 2014
    Role: Principal Investigator
    Transgenic Electrical Silencing of a Neural Circuit
    NIH/NIDA R21DA016352Sep 27, 2002 - Aug 31, 2005
    Role: Principal Investigator
    TYROSINE PHOSPHORYLATION OF ION CHANNELS
    NIH/NINDS F32NS009990Apr 1, 1996
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baik LS, Au DD, Nave C, Foden AJ, Enrriquez-Villalva WK, Holmes TC. Distinct mechanisms of Drosophila CRYPTOCHROME-mediated light-evoked membrane depolarization and in vivo clock resetting. Proc Natl Acad Sci U S A. 2019 Nov 12; 116(46):23339-23344. PMID: 31659046.
      View in: PubMed
    2. Gong N, Hagopian G, Holmes TC, Luo ZD, Xu X. Functional Reorganization of Local Circuit Connectivity in Superficial Spinal Dorsal Horn with Neuropathic Pain States. eNeuro. 2019 Sep/Oct; 6(5). PMID: 31533959.
      View in: PubMed
    3. Guo Z, Lin X, Samaniego T, Isreb A, Cao S, Malik S, Holmes TC, Xu X. Fos-CreER-based genetic mapping of forebrain regions activated by acupuncture. J Comp Neurol. 2019 Oct 10. PMID: 31600836.
      View in: PubMed
    4. Sun Y, Jin S, Lin X, Chen L, Qiao X, Jiang L, Zhou P, Johnston KG, Golshani P, Nie Q, Holmes TC, Nitz DA, Xu X. CA1-projecting subiculum neurons facilitate object-place learning. Nat Neurosci. 2019 Nov; 22(11):1857-1870. PMID: 31548723.
      View in: PubMed
    5. Grieco SF, Wang G, Mahapatra A, Lai C, Holmes TC, Xu X. Neuregulin and ErbB expression is regulated by development and sensory experience in mouse visual cortex. J Comp Neurol. 2020 Feb 15; 528(3):419-432. PMID: 31454079.
      View in: PubMed
    6. Baik LS, Recinos Y, Chevez JA, Au DD, Holmes TC. Multiple Phototransduction Inputs Integrate to Mediate UV Light-evoked Avoidance/Attraction Behavior in Drosophila. J Biol Rhythms. 2019 Aug; 34(4):391-400. PMID: 31140349.
      View in: PubMed
    7. Shi Y, Grieco SF, Holmes TC, Xu X. Development of Local Circuit Connections to Hilar Mossy Cells in the Mouse Dentate Gyrus. eNeuro. 2019 Mar-Apr; 6(2). PMID: 30937358.
      View in: PubMed
    8. Baik LS, Recinos Y, Chevez JA, Holmes TC. Circadian modulation of light-evoked avoidance/attraction behavior in Drosophila. PLoS One. 2018; 13(8):e0201927. PMID: 30106957.
      View in: PubMed
    9. Grieco SF, Holmes TC, Xu X. Neuregulin directed molecular mechanisms of visual cortical plasticity. J Comp Neurol. 2019 Feb 15; 527(3):668-678. PMID: 29464684.
      View in: PubMed
    10. Sun Y, Nitz DA, Holmes TC, Xu X. Opposing and Complementary Topographic Connectivity Gradients Revealed by Quantitative Analysis of Canonical and Noncanonical Hippocampal CA1 Inputs. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29387780.
      View in: PubMed
    11. Ni JD, Baik LS, Holmes TC, Montell C. A rhodopsin in the brain functions in circadian photoentrainment in Drosophila. Nature. 2017 05 18; 545(7654):340-344. PMID: 28489826.
      View in: PubMed
    12. Sun Y, Grieco SF, Holmes TC, Xu X. Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus. eNeuro. 2017 Mar-Apr; 4(2). PMID: 28451637.
      View in: PubMed
    13. Baik LS, Fogle KJ, Roberts L, Galschiodt AM, Chevez JA, Recinos Y, Nguy V, Holmes TC. CRYPTOCHROME mediates behavioral executive choice in response to UV light. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):776-781. PMID: 28062690.
      View in: PubMed
    14. Barber AF, Erion R, Holmes TC, Sehgal A. Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells. Genes Dev. 2016 12 01; 30(23):2596-2606. PMID: 27979876.
      View in: PubMed
    15. Sun Y, Ikrar T, Davis MF, Gong N, Zheng X, Luo ZD, Lai C, Mei L, Holmes TC, Gandhi SP, Xu X. Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity. Neuron. 2016 Oct 05; 92(1):160-173. PMID: 27641496.
      View in: PubMed
    16. Roberts L, Leise TL, Welsh DK, Holmes TC. Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics. J Biol Rhythms. 2016 08; 31(4):337-51. PMID: 27221103.
      View in: PubMed
    17. Xu X, Sun Y, Holmes TC, López AJ. Noncanonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016 12 01; 524(17):3666-3673. PMID: 27150503.
      View in: PubMed
    18. Xu X, Ikrar T, Sun Y, Santos R, Holmes TC, Francesconi W, Berton F. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory vs. strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016 06 01; 115(6):3204-16. PMID: 27052587.
      View in: PubMed
    19. Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 01; 594(7):1891-910. PMID: 26844927.
      View in: PubMed
    20. Das A, Holmes TC, Sheeba V. dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster. J Biol Rhythms. 2016 06; 31(3):272-88. PMID: 26868037.
      View in: PubMed
    21. Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2016 08 15; 524(12):2379-99. PMID: 26718312.
      View in: PubMed
    22. Das A, Holmes TC, Sheeba V. dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster. PLoS One. 2015; 10(7):e0134213. PMID: 26226013.
      View in: PubMed
    23. Roberts L, Leise TL, Noguchi T, Galschiodt AM, Houl JH, Welsh DK, Holmes TC. Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony. Curr Biol. 2015 Mar 30; 25(7):858-67. PMID: 25754644.
      View in: PubMed
    24. Fogle KJ, Baik LS, Houl JH, Tran TT, Roberts L, Dahm NA, Cao Y, Zhou M, Holmes TC. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel ß-subunit redox sensor. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2245-50. PMID: 25646452.
      View in: PubMed
    25. Helfrich-Förster C, Nitabach MN, Holmes TC. Insect circadian clock outputs. Essays Biochem. 2011 Jun 30; 49(1):87-101. PMID: 21819386.
      View in: PubMed
    26. Fogle KJ, Parson KG, Dahm NA, Holmes TC. CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate. Science. 2011 Mar 18; 331(6023):1409-13. PMID: 21385718.
      View in: PubMed
    27. Sheeba V, Fogle KJ, Holmes TC. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. PLoS One. 2010 Jul 16; 5(7):e11628. PMID: 20661292.
      View in: PubMed
    28. Sheeba V, Fogle KJ, Kaneko M, Rashid S, Chou YT, Sharma VK, Holmes TC. Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol. 2008 Oct 28; 18(20):1537-45. PMID: 18771923.
      View in: PubMed
    29. Ayaz D, Leyssen M, Koch M, Yan J, Srahna M, Sheeba V, Fogle KJ, Holmes TC, Hassan BA. Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci. 2008 Jun 04; 28(23):6010-21. PMID: 18524906.
      View in: PubMed
    30. Sheeba V, Sharma VK, Gu H, Chou YT, O'Dowd DK, Holmes TC. Pigment dispersing factor-dependent and -independent circadian locomotor behavioral rhythms. J Neurosci. 2008 Jan 02; 28(1):217-27. PMID: 18171939.
      View in: PubMed
    31. Sheeba V, Kaneko M, Sharma VK, Holmes TC. The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella? Crit Rev Biochem Mol Biol. 2008 Jan-Feb; 43(1):37-61. PMID: 18307108.
      View in: PubMed
    32. Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC. Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. J Neurophysiol. 2008 Feb; 99(2):976-88. PMID: 18077664.
      View in: PubMed
    33. Nitabach MN, Wu Y, Sheeba V, Lemon WC, Strumbos J, Zelensky PK, White BH, Holmes TC. Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci. 2006 Jan 11; 26(2):479-89. PMID: 16407545.
      View in: PubMed
    34. Luan H, Lemon WC, Peabody NC, Pohl JB, Zelensky PK, Wang D, Nitabach MN, Holmes TC, White BH. Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J Neurosci. 2006 Jan 11; 26(2):573-84. PMID: 16407556.
      View in: PubMed
    35. Holmes TC, Sheeba V. Circadian pathway: the other shoe drops. Curr Biol. 2005 Dec 20; 15(24):R987-9. PMID: 16360675.
      View in: PubMed
    36. Nitabach MN, Sheeba V, Vera DA, Blau J, Holmes TC. Membrane electrical excitability is necessary for the free-running larval Drosophila circadian clock. J Neurobiol. 2005 Jan; 62(1):1-13. PMID: 15389695.
      View in: PubMed
    37. Nitabach MN, Holmes TC, Blau J. Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator. Methods Enzymol. 2005; 393:682-93. PMID: 15817319.
      View in: PubMed
    38. Holmes TC. The end of single-molecule envy. Chem Biol. 2005 Jan; 12(1):8-10. PMID: 15664509.
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    39. Nitabach MN, Llamas DA, Thompson IJ, Collins KA, Holmes TC. Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases. J Neurosci. 2002 Sep 15; 22(18):7913-22. PMID: 12223544.
      View in: PubMed
    40. Chiu JC, Brenner ED, DeSalle R, Nitabach MN, Holmes TC, Coruzzi GM. Phylogenetic and expression analysis of the glutamate-receptor-like gene family in Arabidopsis thaliana. Mol Biol Evol. 2002 Jul; 19(7):1066-82. PMID: 12082126.
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    41. Nitabach MN, Blau J, Holmes TC. Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell. 2002 May 17; 109(4):485-95. PMID: 12086605.
      View in: PubMed
    42. Holmes TC. Ion channel-directed therapies in autonomic neurons: a view from the bench. Clin Auton Res. 2002 Apr; 12(2):59-65. PMID: 12102451.
      View in: PubMed
    43. Holmes TC. Novel peptide-based biomaterial scaffolds for tissue engineering. Trends Biotechnol. 2002 Jan; 20(1):16-21. PMID: 11742673.
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    44. Pountney DJ, Sun ZQ, Porter LM, Nitabach MN, Nakamura TY, Holmes D, Rosner E, Kaneko M, Manaris T, Holmes TC, Coetzee WA. Is the molecular composition of K(ATP) channels more complex than originally thought? J Mol Cell Cardiol. 2001 Aug; 33(8):1541-6. PMID: 11448141.
      View in: PubMed
    45. Nitabach MN, Llamas DA, Araneda RC, Intile JL, Thompson IJ, Zhou YI, Holmes TC. A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):705-10. PMID: 11149959.
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    46. Holmes TC, Berman K, Swartz JE, Dagan D, Levitan IB. Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation. J Neurosci. 1997 Dec 01; 17(23):8964-74. PMID: 9364044.
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    47. Bowlby MR, Fadool DA, Holmes TC, Levitan IB. Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J Gen Physiol. 1997 Nov; 110(5):601-10. PMID: 9348331.
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    48. Fadool DA, Holmes TC, Berman K, Dagan D, Levitan IB. Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. J Neurophysiol. 1997 Sep; 78(3):1563-73. PMID: 9310443.
      View in: PubMed
    49. Holmes TC, Fadool DA, Ren R, Levitan IB. Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science. 1996 Dec 20; 274(5295):2089-91. PMID: 8953041.
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    50. Holmes TC, Fadool DA, Levitan IB. Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci. 1996 Mar 01; 16(5):1581-90. PMID: 8774427.
      View in: PubMed
    51. Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials. 1995 Dec; 16(18):1385-93. PMID: 8590765.
      View in: PubMed
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