Jorge A. Busciglio

Title(s)Professor, Neurobiology & Behavior
SchoolSchool of Biological Sciences
Address3216 Biological Sciences III
Zot 4545
Irvine CA 92697
Phone(949) 824-9075
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Inflammation and NGF Dysfunction in the Evolution of AlzheimerDisease Pathology in Down syndrome
    NIH RF1AG056850Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    The Role of Inflammation and NGF Dysfunction in the Evolution of AlzheimerDisease Pathology in Down syndrome
    NIH/NIA R01AG056850Apr 1, 2018 - Dec 31, 2022
    Role: Principal Investigator
    2nd International Conference of the Trisomy 21 Research Society
    NIH R13NS100380Sep 1, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Combinational pharmacotherapies for neuronal abnormalities in Down syndrome
    NIH R21HD076456Jan 1, 2015 - Dec 31, 2016
    Role: Co-Principal Investigator
    iPSC from British and Danish dementias: new discovery tools for brain amyloidoses
    NIH R21AG044817Sep 30, 2013 - Jul 31, 2017
    Role: Co-Principal Investigator
    Mitochondrial Dysfunction in Down's Syndrome
    NIH R01HD038466Mar 1, 2000 - Jun 30, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome. Alzheimers Dement. 2023 11; 19(11):4817-4827. Rozalem Aranha M, Iulita MF, Montal V, Pegueroles J, Bejanin A, Vaqué-Alcázar L, Grothe MJ, Carmona-Iragui M, Videla L, Benejam B, Arranz J, Padilla C, Valldeneu S, Barroeta I, Altuna M, Fernández S, Ribas L, Valle-Tamayo N, Alcolea D, González-Ortiz S, Bargalló N, Zetterberg H, Blennow K, Blesa R, Wisniewski T, Busciglio J, Cuello AC, Lleó A, Fortea J. PMID: 37021589.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Genetic removal of synaptic Zn2+ impairs cognition, alters neurotrophic signaling and induces neuronal hyperactivity. Front Neurol. 2022; 13:882635. Vogler EC, Mahavongtrakul M, Sarkan K, Bohannan RC, Catuara-Solarz S, Busciglio J. PMID: 36742045; PMCID: PMC9895830.
      View in: PubMed   Mentions: 1  
    3. Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society. Mol Syndromol. 2023 Apr; 14(2):89-100. Hamlett ED, Flores-Aguilar L, Handen B, Potier MC, Granholm AC, Sherman S, Puig V, Santoro JD, Carmona-Iragui M, Rebillat AS, Head E, Strydom A, Busciglio J. PMID: 37064334; PMCID: PMC10090974.
      View in: PubMed   Mentions:
    4. Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission. Nat Commun. 2021 10 27; 12(1):6208. Yeo M, Chen Y, Jiang C, Chen G, Wang K, Chandra S, Bortsov A, Lioudyno M, Zeng Q, Wang P, Wang Z, Busciglio J, Ji RR, Liedtke W. PMID: 34707084; PMCID: PMC8551327.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    5. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218. Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. PMID: 34421499; PMCID: PMC8339505.
      View in: PubMed   Mentions: 2  
    6. Evolution of neuroinflammation across the lifespan of individuals with Down syndrome. Brain. 2020 12 01; 143(12):3653-3671. Flores-Aguilar L, Iulita MF, Kovecses O, Torres MD, Levi SM, Zhang Y, Askenazi M, Wisniewski T, Busciglio J, Cuello AC. PMID: 33206953; PMCID: PMC7805813.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    7. Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells. Cell Rep. 2019 11 19; 29(8):2473-2488.e5. Hwang S, Williams JF, Kneissig M, Lioudyno M, Rivera I, Helguera P, Busciglio J, Storchova Z, King MC, Torres EM. PMID: 31747614; PMCID: PMC6886690.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    8. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2019 Jan; 9(6):279-286. Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. PMID: 30800043; PMCID: PMC6381890.
      View in: PubMed   Mentions: 5  
    9. Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells. Aging Cell. 2018 Oct; 17(5):e12812. Zamponi E, Zamponi N, Coskun P, Quassollo G, Lorenzo A, Cannas SA, Pigino G, Chialvo DR, Gardiner K, Busciglio J, Helguera P. PMID: 30028071; PMCID: PMC6156351.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    10. Low Cost Electrode Assembly for EEG Recordings in Mice. Front Neurosci. 2017; 11:629. Vogler EC, Flynn DT, Busciglio F, Bohannan RC, Tran A, Mahavongtrakul M, Busciglio JA. PMID: 29184480; PMCID: PMC5694541.
      View in: PubMed   Mentions: 2  
    11. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radic Biol Med. 2018 01; 114:10-14. Torres MD, Garcia O, Tang C, Busciglio J. PMID: 28965914; PMCID: PMC7185223.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    12. Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease. J Alzheimers Dis. 2017; 55(2):737-748. Coskun P, Helguera P, Nemati Z, Bohannan RC, Thomas J, Samuel SE, Argueta J, Doran E, Wallace DC, Lott IT, Busciglio J. PMID: 27802222.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2016 Oct; 7(5):251-261. Delabar JM, Allinquant B, Bianchi D, Blumenthal T, Dekker A, Edgin J, O'Bryan J, Dierssen M, Potier MC, Wiseman F, Guedj F, Créau N, Reeves R, Gardiner K, Busciglio J. PMID: 27867340; PMCID: PMC5109983.
      View in: PubMed   Mentions: 12  
    14. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 05; 12(5):e1006033. Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ. PMID: 27195491; PMCID: PMC4873152.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    15. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain. 2014 Mar; 137(Pt 3):860-72. Iulita MF, Do Carmo S, Ower AK, Fortress AM, Flores Aguilar L, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC. PMID: 24519975; PMCID: PMC3927704.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    16. Disruption of zinc neuromodulation by Aß oligomers: therapeutic implications. Curr Pharm Des. 2014; 20(15):2520-4. Vogler EC, Busciglio J. PMID: 23859544.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome. FASEB J. 2014 Jan; 28(1):195-205. Sosa LJ, Postma NL, Estrada-Bernal A, Hanna M, Guo R, Busciglio J, Pfenninger KH. PMID: 24036883; PMCID: PMC3868833.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. Down syndrome: genes, model systems, and progress towards pharmacotherapies and clinical trials for cognitive deficits. Cytogenet Genome Res. 2013; 141(4):260-71. Busciglio J, Capone G, O'Bryan J, O'Byran JP, Gardiner KJ. PMID: 24008277.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    19. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4315-20. Yeo M, Berglund K, Hanna M, Guo JU, Kittur J, Torres MD, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke WB. PMID: 23440186; PMCID: PMC3600491.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    20. Adaptive downregulation of mitochondrial function in down syndrome. Cell Metab. 2013 Jan 08; 17(1):132-40. Helguera P, Seiglie J, Rodriguez J, Hanna M, Helguera G, Busciglio J. PMID: 23312288; PMCID: PMC3580189.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    21. Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia. Curr Gerontol Geriatr Res. 2012; 2012:383170. Coskun PE, Busciglio J. PMID: 22611387; PMCID: PMC3350950.
      View in: PubMed   Mentions: 38  
    22. Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ? Biofactors. 2011 Sep-Oct; 37(5):386-92. Tiano L, Busciglio J. PMID: 22009852.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    23. A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome. PLoS One. 2010 Dec 02; 5(12):e14200. Garcia O, Torres M, Helguera P, Coskun P, Busciglio J. PMID: 21152035; PMCID: PMC2996288.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    24. Cryopreservation of cortical tissue blocks for the generation of highly enriched neuronal cultures. J Vis Exp. 2010 Nov 11; (45). Rahman AS, Parvinjah S, Hanna MA, Helguera PR, Busciglio J. PMID: 21113113; PMCID: PMC3159608.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. PMID: 19339596; PMCID: PMC6665357.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    26. Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5907-12. Pigino G, Morfini G, Atagi Y, Deshpande A, Yu C, Jungbauer L, LaDu M, Busciglio J, Brady S. PMID: 19321417; PMCID: PMC2667037.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    27. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med. 2008 Jun 15; 44(12):2051-7. Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR. PMID: 18423383.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    28. Tau isoform expression and regulation in human cortical neurons. FASEB J. 2008 Jul; 22(7):2357-67. Deshpande A, Win KM, Busciglio J. PMID: 18263702.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    29. NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis. Curr Pharm Des. 2007; 13(11):1091-8. Busciglio J, Pelsman A, Helguera P, Ashur-Fabian O, Pinhasov A, Brenneman DE, Gozes I. PMID: 17430172.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    30. Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res. 2006 Dec; 3(5):521-8. Lott IT, Head E, Doran E, Busciglio J. PMID: 17168651.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    31. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci. 2006 Jun 14; 26(24):6533-42. Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. PMID: 16775141; PMCID: PMC6674046.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    32. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci. 2006 May 31; 26(22):6011-8. Deshpande A, Mina E, Glabe C, Busciglio J. PMID: 16738244; PMCID: PMC6675207.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCells
    33. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. J Neurosci. 2005 Mar 02; 25(9):2295-303. Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. PMID: 15745955; PMCID: PMC6726094.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    34. Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein. Neurobiol Dis. 2004 Aug; 16(3):617-29. Heredia L, Lin R, Vigo FS, Kedikian G, Busciglio J, Lorenzo A. PMID: 15262274.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002. J Alzheimers Dis. 2003 Dec; 5(6):483-9. Goldstein L, Ashford JW, Busciglio J, Crutcher K, Gouras G, Kinoshita J, Mandelkow E, Sudol M. PMID: 14765517.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiol Dis. 2003 Dec; 14(3):349-56. Wolvetang EJ, Bradfield OM, Hatzistavrou T, Crack PJ, Busciglio J, Kola I, Hertzog PJ. PMID: 14678752.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    37. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci. 2003 Jun 01; 23(11):4499-508. Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. PMID: 12805290; PMCID: PMC6740780.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    38. GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. Int J Dev Neurosci. 2003 May; 21(3):117-24. Pelsman A, Hoyo-Vadillo C, Gudasheva TA, Seredenin SB, Ostrovskaya RU, Busciglio J. PMID: 12711349.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum Mol Genet. 2003 Feb 01; 12(3):247-55. Wolvetang EJ, Wilson TJ, Sanij E, Busciglio J, Hatzistavrou T, Seth A, Hertzog PJ, Kola I. PMID: 12554679.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    40. Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy. J Neurosci. 2003 Jan 15; 23(2):493-502. Grace EA, Busciglio J. PMID: 12533609; PMCID: PMC6741895.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    41. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 2002 Feb 28; 33(5):677-88. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. PMID: 11879646.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    42. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Med. 2002; 2(2):89-99. Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST. PMID: 12428805.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    43. Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease. Neuroscience. 2002; 114(1):265-73. Grace EA, Rabiner CA, Busciglio J. PMID: 12207971.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    44. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci. 2001 Feb 01; 21(3):834-42. Pigino G, Pelsman A, Mori H, Busciglio J. PMID: 11157069; PMCID: PMC6762317.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    45. Fetal human cortical neurons grown in culture: morphological differentiation, biochemical correlates and development of electrical activity. Int J Dev Neurosci. 1999 Jul; 17(4):347-56. Kerkovich DM, Sapp D, Weidenheim K, Brosnan CF, Pfeiffer SE, Yeh HH, Busciglio J. PMID: 10479069.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    46. Stress, aging, and neurodegenerative disorders. Molecular mechanisms. Ann N Y Acad Sci. 1998 Jun 30; 851:429-43. Busciglio J, Andersen JK, Schipper HM, Gilad GM, McCarty R, Marzatico F, Toussaint O. PMID: 9668637.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    47. Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. J Neurovirol. 1998 Jun; 4(3):281-90. Shi B, Raina J, Lorenzo A, Busciglio J, Gabuzda D. PMID: 9639071.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    48. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci. 1997 Jul 01; 17(13):5101-7. Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. PMID: 9185547; PMCID: PMC6573321.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    49. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem. 1997 Jun 06; 272(23):14505-8. Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. PMID: 9169406.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. Astrocyte apoptosis induced by HIV-1 transactivation of the c-kit protooncogene. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3954-9. He J, deCastro CM, Vandenbark GR, Busciglio J, Gabuzda D. PMID: 9108086; PMCID: PMC20549.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    51. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature. 1997 Feb 13; 385(6617):645-9. He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D. PMID: 9024664.
      View in: PubMed   Mentions: 342     Fields:    Translation:HumansCells
    52. Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest. 1996 Nov 01; 98(9):1979-90. Shi B, De Girolami U, He J, Wang S, Lorenzo A, Busciglio J, Gabuzda D. PMID: 8903316; PMCID: PMC507641.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    53. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 1995 Dec 21-28; 378(6559):776-9. Busciglio J, Yankner BA. PMID: 8524410.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansCells
    54. Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem. 1995 Nov 10; 270(45):26727-30. Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA. PMID: 7592902.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    55. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 1995 Apr; 14(4):879-88. Busciglio J, Lorenzo A, Yeh J, Yankner BA. PMID: 7718249.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    56. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem. 1994 May 06; 269(18):13623-8. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. PMID: 8175797.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    57. Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem. 1993 Dec; 61(6):2326-9. Gabuzda D, Busciglio J, Yankner BA. PMID: 8245986.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    58. beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem. 1993 Oct; 61(4):1565-8. Busciglio J, Yeh J, Yankner BA. PMID: 8377009.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    59. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):2092-6. Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA. PMID: 8446635; PMCID: PMC46027.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    60. Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):609-12. Busciglio J, Lorenzo A, Yankner BA. PMID: 1461350.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    61. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7247-51. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. PMID: 1714596; PMCID: PMC52271.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    62. Tyrosinated and detyrosinated microtubules in axonal processes of cerebellar macroneurons grown in culture. J Neurosci Res. 1991 Feb; 28(2):171-81. Arregui C, Busciglio J, Caceres A, Barra HS. PMID: 1674546.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    63. Coexpression of lactosyl and gangliotetraosyl gangliosides in rat cerebellar radial glial cells in culture. J Neurosci Res. 1990 Feb; 25(2):214-22. Gravotta D, Ferreira A, Busciglio J, Caceres A, Landa CA, Maccioni HJ. PMID: 2319630.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    64. Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2. J Neurosci. 1990 Jan; 10(1):293-302. Ferreira A, Busciglio J, Landa C, Caceres A. PMID: 2153774; PMCID: PMC6570343.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    65. Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Brain Res Dev Brain Res. 1989 Oct 01; 49(2):215-28. Ferreira A, Busciglio J, Cáceres A. PMID: 2509111.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    66. An immunocytochemical and biochemical study of the microtubule-associated protein MAP-2 during post-lesion dendritic remodeling in the central nervous system of adult rats. Brain Res. 1988 Jun; 427(3):233-46. Cáceres A, Busciglio J, Ferreira A, Steward O. PMID: 3042088.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    67. An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats. Brain Res. 1987 Sep 01; 419(1-2):244-52. Busciglio J, Ferreira A, Steward O, Cáceres A. PMID: 3119145.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    68. An immunocytochemical analysis of the ontogeny of the microtubule-associated proteins MAP-2 and Tau in the nervous system of the rat. Brain Res. 1987 Jul; 431(1):9-31. Ferreira A, Busciglio J, Cáceres A. PMID: 3113673.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
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