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Busciglio, Jorge A

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address3216 Biological Sciences III
Zot 4545
CA 92697
Phone(949) 824-9075
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    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Inflammation and NGF Dysfunction in the Evolution of AlzheimerDisease Pathology in Down syndrome
    NIH/NIA R01AG056850Apr 1, 2018 - Dec 31, 2022
    Role: Principal Investigator
    2nd International Conference of the Trisomy 21 Research Society
    NIH/NINDS R13NS100380Sep 1, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Combinational pharmacotherapies for neuronal abnormalities in Down syndrome
    NIH/NICHD R21HD076456Jan 1, 2015 - Dec 31, 2016
    Role: Co-Principal Investigator
    iPSC from British and Danish dementias: new discovery tools for brain amyloidoses
    NIH/NIA R21AG044817Sep 30, 2013 - Jul 31, 2015
    Role: Co-Principal Investigator
    Mitochondrial Dysfunction in Down's Syndrome
    NIH/NICHD R01HD038466Mar 1, 2000 - Jun 30, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zamponi E, Zamponi N, Coskun P, Quassollo G, Lorenzo A, Cannas SA, Pigino G, Chialvo D, Gardiner K, Busciglio J, Helguera P. Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells. Aging Cell. 2018 Jul 20; e12812. PMID: 30028071.
      View in: PubMed
    2. Vogler EC, Flynn DT, Busciglio F, Bohannan RC, Tran A, Mahavongtrakul M, Busciglio J. Low Cost Electrode Assembly for EEG Recordings in Mice. Front Neurosci. 2017; 11:629. PMID: 29184480.
      View in: PubMed
    3. Torres MD, Garcia O, Tang C, Busciglio J. Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome. Free Radic Biol Med. 2018 Jan; 114:10-14. PMID: 28965914.
      View in: PubMed
    4. Coskun P, Helguera P, Nemati Z, Bohannan RC, Thomas J, Samuel SE, Argueta J, Doran E, Wallace DC, Lott IT, Busciglio J. Metabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease. J Alzheimers Dis. 2017; 55(2):737-748. PMID: 27802222.
      View in: PubMed
    5. Delabar JM, Allinquant B, Bianchi D, Blumenthal T, Dekker A, Edgin J, O'Bryan J, Dierssen M, Potier MC, Wiseman F, Guedj F, Créau N, Reeves R, Gardiner K, Busciglio J. Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society. Mol Syndromol. 2016 Oct; 7(5):251-261. PMID: 27867340.
      View in: PubMed
    6. Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ß-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016 May; 12(5):e1006033. PMID: 27195491; PMCID: PMC4873152.
    7. Iulita MF, Do Carmo S, Ower AK, Fortress AM, Flores Aguilar L, Hanna M, Wisniewski T, Granholm AC, Buhusi M, Busciglio J, Cuello AC. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain. 2014 Mar; 137(Pt 3):860-72. PMID: 24519975; PMCID: PMC3927704.
    8. Vogler EC, Busciglio J. Disruption of zinc neuromodulation by Aß oligomers: therapeutic implications. Curr Pharm Des. 2014; 20(15):2520-4. PMID: 23859544.
      View in: PubMed
    9. Sosa LJ, Postma NL, Estrada-Bernal A, Hanna M, Guo R, Busciglio J, Pfenninger KH. Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome. FASEB J. 2014 Jan; 28(1):195-205. PMID: 24036883; PMCID: PMC3868833.
    10. Yeo M, Berglund K, Hanna M, Guo JU, Kittur J, Torres MD, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke WB. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4315-20. PMID: 23440186; PMCID: PMC3600491.
    11. Helguera P, Seiglie J, Rodriguez J, Hanna M, Helguera G, Busciglio J. Adaptive downregulation of mitochondrial function in down syndrome. Cell Metab. 2013 Jan 08; 17(1):132-40. PMID: 23312288; PMCID: PMC3580189.
    12. Coskun PE, Busciglio J. Oxidative Stress and Mitochondrial Dysfunction in Down's Syndrome: Relevance to Aging and Dementia. Curr Gerontol Geriatr Res. 2012; 2012:383170. PMID: 22611387; PMCID: PMC3350950.
    13. Tiano L, Busciglio J. Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ? Biofactors. 2011 Sep-Oct; 37(5):386-92. PMID: 22009852.
      View in: PubMed
    14. Garcia O, Torres M, Helguera P, Coskun P, Busciglio J. A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome. PLoS One. 2010 Dec 02; 5(12):e14200. PMID: 21152035; PMCID: PMC2996288.
    15. Rahman AS, Parvinjah S, Hanna MA, Helguera PR, Busciglio J. Cryopreservation of cortical tissue blocks for the generation of highly enriched neuronal cultures. J Vis Exp. 2010 Nov 11; (45). PMID: 21113113; PMCID: PMC3159608.
    16. Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. PMID: 19339596.
      View in: PubMed
    17. Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med. 2008 Jun 15; 44(12):2051-7. PMID: 18423383.
      View in: PubMed
    18. Deshpande A, Win KM, Busciglio J. Tau isoform expression and regulation in human cortical neurons. FASEB J. 2008 Jul; 22(7):2357-67. PMID: 18263702.
      View in: PubMed
    19. Busciglio J, Pelsman A, Helguera P, Ashur-Fabian O, Pinhasov A, Brenneman DE, Gozes I. NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis. Curr Pharm Des. 2007; 13(11):1091-8. PMID: 17430172.
      View in: PubMed
    20. Lott IT, Head E, Doran E, Busciglio J. Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res. 2006 Dec; 3(5):521-8. PMID: 17168651.
      View in: PubMed
    21. Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A. Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease. J Neurosci. 2006 Jun 14; 26(24):6533-42. PMID: 16775141.
      View in: PubMed
    22. Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci. 2006 May 31; 26(22):6011-8. PMID: 16738244.
      View in: PubMed
    23. Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. J Neurosci. 2005 Mar 02; 25(9):2295-303. PMID: 15745955.
      View in: PubMed
    24. Heredia L, Lin R, Vigo FS, Kedikian G, Busciglio J, Lorenzo A. Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein. Neurobiol Dis. 2004 Aug; 16(3):617-29. PMID: 15262274.
      View in: PubMed
    25. Goldstein L, Ashford JW, Busciglio J, Crutcher K, Gouras G, Kinoshita J, Mandelkow E, Sudol M. Live discussion. From here to there: AbetaPP as an axonal transport receptor--how could this explain neurodegeneration in AD. 15 July 2002. J Alzheimers Dis. 2003 Dec; 5(6):483-9. PMID: 14765517.
      View in: PubMed
    26. Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci. 2003 Jun 01; 23(11):4499-508. PMID: 12805290.
      View in: PubMed
    27. Pelsman A, Hoyo-Vadillo C, Gudasheva TA, Seredenin SB, Ostrovskaya RU, Busciglio J. GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. Int J Dev Neurosci. 2003 May; 21(3):117-24. PMID: 12711349.
      View in: PubMed
    28. Grace EA, Busciglio J. Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy. J Neurosci. 2003 Jan 15; 23(2):493-502. PMID: 12533609.
      View in: PubMed
    29. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 2002 Feb 28; 33(5):677-88. PMID: 11879646.
      View in: PubMed
    30. Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST. Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Med. 2002; 2(2):89-99. PMID: 12428805.
      View in: PubMed
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