Yama Akbari

Title(s)	Associate Professor, Neurology
School	School of Medicine
Address	1001 Health Sciences Road Irvine CA 92697-3950
Phone	(949) 824-1888
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Research

Research Activities and Funding

Multimodal Optical Imaging of Hyperdynamic Cerebral Responses to Cardiac Arrest and Resuscitation
NIH R21EB024793Aug 15, 2017 - May 31, 2021
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Point-of-Care Brain MRI: Preliminary Results from a Single-Center Retrospective Study. Radiology. 2022 12; 305(3):666-671. Kuoy E, Glavis-Bloom J, Hovis G, Yep B, Biswas A, Masudathaya LA, Norrick LA, Limfueco J, Soun JE, Chang PD, Chu E, Akbari Y, Yaghmai V, Fox JC, Yu W, Chow DS. PMID: 35916678; PMCID: PMC9713449.

View in: PubMed Mentions: 6 Fields:
Rad Radiology
Translation:Humans
Blocking Mitochondrial Zn2+ Accumulation after Ischemia Reduces Mitochondrial Dysfunction and Neuronal Injury. J Neurosci. 2022 Jun 29; 42(26):5281-5292. Medvedeva YV, Yin HZ, Bazrafkan A, Yeromin A, Ji SG, Weiss-Hung EJ, Sharman E, Avilez AP, Maki N, Rafi MA, Tian G, Akbari Y, Weiss JH. PMID: 35623885; PMCID: PMC9236293.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome. Neurocrit Care. 2022 06; 37(Suppl 1):139-154. Han S, Contreras MI, Bazrafkan A, Rafi M, Dara SM, Orujyan A, Panossian A, Crouzet C, Lopour B, Choi B, Wilson RH, Akbari Y. PMID: 35729464; PMCID: PMC9259534.

View in: PubMed Mentions: 3 Fields:
Cri Critical Care Neu Neurology
Translation:Animals
Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative. J Stroke Cerebrovasc Dis. 2021 Dec; 30(12):106121. Sasanejad P, Afshar Hezarkhani L, Arsang-Jang S, Tsivgoulis G, Ghoreishi A, Barlinn K, Rahmig J, Farhoudi M, Sadeghi Hokmabadi E, Borhani-Haghighi A, Sariaslani P, Sharifi-Razavi A, Ghandehari K, Khosravi A, Smith C, Nilanont Y, Akbari Y, Nguyen TN, Bersano A, Yassi N, Yoshimoto T, Lattanzi S, Gupta A, Zand R, Rafie S, Pourandokht Mousavian S, Reza Shahsavaripour M, Amini S, Kamenova SU, Kondybayeva A, Zhanuzakov M, Macri EM, Nobleza COS, Ruland S, Cervantes-Arslanian AM, Desai MJ, Ranta A, Moghadam Ahmadi A, Rostamihosseinkhani M, Foroughi R, Hooshmandi E, Akhoundi FH, Shuaib A, Liebeskind DS, Siegler J, Romano JG, Mayer SA, Bavarsad Shahripour R, Zamani B, Woolsey A, Fazli Y, Mojtaba K, Isaac CF, Biller J, Di Napoli M, Azarpazhooh MR. PMID: 34601242; PMCID: PMC8450304.

View in: PubMed Mentions: 9 Fields:
Bra Brain Vas Vascular Diseases
Translation:Humans
Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocrit Care. 2021 07; 35(Suppl 1):4-23. Claassen J, Akbari Y, Alexander S, Bader MK, Bell K, Bleck TP, Boly M, Brown J, Chou SH, Diringer MN, Edlow BL, Foreman B, Giacino JT, Gosseries O, Green T, Greer DM, Hanley DF, Hartings JA, Helbok R, Hemphill JC, Hinson HE, Hirsch K, Human T, James ML, Ko N, Kondziella D, Livesay S, Madden LK, Mainali S, Mayer SA, McCredie V, McNett MM, Meyfroidt G, Monti MM, Muehlschlegel S, Murthy S, Nyquist P, Olson DM, Provencio JJ, Rosenthal E, Sampaio Silva G, Sarasso S, Schiff ND, Sharshar T, Shutter L, Stevens RD, Vespa P, Videtta W, Wagner A, Ziai W, Whyte J, Zink E, Suarez JI, Curing Coma Campaign. PMID: 34236619; PMCID: PMC8264966.

View in: PubMed Mentions: 23 Fields:
Cri Critical Care Neu Neurology
Translation:Humans
High-speed quantitative optical imaging of absolute metabolism in the rat cortex. Neurophotonics. 2021 Apr; 8(2):025001. Wilson RH, Crouzet C, Torabzadeh M, Bazrafkan A, Maki N, Tromberg BJ, Akbari Y, Choi B. PMID: 33842666; PMCID: PMC8027868.

View in: PubMed Mentions: 5
Overnight Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model. Front Neurosci. 2020; 14:609670. Azadian M, Tian G, Bazrafkan A, Maki N, Rafi M, Chetty N, Desai M, Otarola I, Aguirre F, Zaher SM, Khan A, Suri Y, Wang M, Lopour BA, Steward O, Akbari Y. PMID: 33510613; PMCID: PMC7835645.

View in: PubMed Mentions: 4
Intracerebral hemorrhage: who gets tested for methamphetamine use and why might it matter? BMC Neurol. 2020 Oct 27; 20(1):392. Osman S, Zhu Z, Farag M, Groysman L, Dastur C, Akbari Y, Stern-Nezer S, Stradling D, Yu W. PMID: 33109106; PMCID: PMC7592363.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Humans
Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results. J Stroke Cerebrovasc Dis. 2020 Dec; 29(12):105321. Ghoreishi A, Arsang-Jang S, Sabaa-Ayoun Z, Yassi N, Sylaja PN, Akbari Y, Divani AA, Biller J, Phan T, Steinwender S, Silver B, Zand R, Basri HB, Iqbal OM, Ranta A, Ruland S, Macri E, Ma H, Nguyen TN, Abootalebi S, Gupta A, Alet M, Lattanzi S, Desai M, Gagliardi RJ, Girotra T, Inoue M, Yoshimoto T, Isaac CF, Mayer SA, Morovatdar N, Nilanont Y, Nobleza COS, Saber H, Kamenova S, Kondybayeva A, Krupinski J, Siegler JE, Stranges S, Torbey MT, Yorio D, Zurrú MC, Rubinos CA, Shahripour RB, Borhani-Haghighi A, Napoli MD, Azarpazhooh MR. PMID: 33069086; PMCID: PMC7494258.

View in: PubMed Mentions: 12 Fields:
Bra Brain Vas Vascular Diseases
Translation:Humans
The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting. Neurocrit Care. 2020 08; 33(1):1-12. Provencio JJ, Hemphill JC, Claassen J, Edlow BL, Helbok R, Vespa PM, Diringer MN, Polizzotto L, Shutter L, Suarez JI, Stevens RD, Hanley DF, Akbari Y, Bleck TP, Boly M, Foreman B, Giacino JT, Hartings JA, Human T, Kondziella D, Ling GSF, Mayer SA, McNett M, Menon DK, Meyfroidt G, Monti MM, Park S, Pouratian N, Puybasset L, Rohaut B, Rosenthal ES, Schiff ND, Sharshar T, Wagner A, Whyte J, Olson DM, Neurocritical Care Society Curing Coma Campaign. PMID: 32578124; PMCID: PMC7392933.

View in: PubMed Mentions: 49 Fields:
Cri Critical Care Neu Neurology
Translation:Humans
Early Initiation of Oral Antihypertensives Reduces Intensive Care Unit Stay and Hospital Cost for Patients with Hypertensive Intracerebral Hemorrhage. Neurocrit Care. 2020 06; 32(3):707-714. Zhu Z, Bower M, Stern-Nezer S, Atallah S, Stradling D, Groysman L, Dastur CK, Akbari Y, Yu W. PMID: 32253732.

View in: PubMed Mentions: 5 Fields:
Cri Critical Care Neu Neurology
Translation:Humans
Resuscitating the Globally Ischemic Brain: TTM and Beyond. Neurotherapeutics. 2020 04; 17(2):539-562. Hosseini M, Wilson RH, Crouzet C, Amirhekmat A, Wei KS, Akbari Y. PMID: 32367476; PMCID: PMC7283450.

View in: PubMed Mentions: 11 Fields:
Neu Neurology
Translation:Humans Animals
Which Spreading Depolarizations Are Deleterious To Brain Tissue? Neurocrit Care. 2020 02; 32(1):317-322. Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM, Rosenthal ES, Watanabe T, Hartings JA. PMID: 31388871; PMCID: PMC7002178.

View in: PubMed Mentions: 22 Fields:
Cri Critical Care Neu Neurology
Translation:Humans Animals
Dissociation of Cerebral Blood Flow and Femoral Artery Blood Pressure Pulsatility After Cardiac Arrest and Resuscitation in a Rodent Model: Implications for Neurological Recovery. J Am Heart Assoc. 2020 01 07; 9(1):e012691. Crouzet C, Wilson RH, Lee D, Bazrafkan A, Tromberg BJ, Akbari Y, Choi B. PMID: 31902319; PMCID: PMC6988151.

View in: PubMed Mentions: 6 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals
Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death. J Neuropathol Exp Neurol. 2019 07 01; 78(7):655-664. Yin HZ, Wang HL, Ji SG, Medvedeva YV, Tian G, Bazrafkan AK, Maki NZ, Akbari Y, Weiss JH. PMID: 31150090; PMCID: PMC6581555.

View in: PubMed Mentions: 9 Fields:
Neu Neurology Pat Pathology
Translation:Animals Cells
High-speed spatial frequency domain imaging of rat cortex detects dynamic optical and physiological properties following cardiac arrest and resuscitation. Neurophotonics. 2017 Oct; 4(4):045008. Wilson RH, Crouzet C, Torabzadeh M, Bazrafkan A, Farahabadi MH, Jamasian B, Donga D, Alcocer J, Zaher SM, Choi B, Akbari Y, Tromberg BJ. PMID: 29296630; PMCID: PMC5742642.

View in: PubMed Mentions: 19
Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway. J Neurotrauma. 2017 10 01; 34(19):2823-2832. Kang YJ, Tian G, Bazrafkan A, Farahabadi MH, Azadian M, Abbasi H, Shamaoun BE, Steward O, Akbari Y. PMID: 28447885; PMCID: PMC5647501.

View in: PubMed Mentions: 10 Fields:
Neu Neurology Tra Traumatology
Translation:Animals
Resistant Hypertension after Hypertensive Intracerebral Hemorrhage Is Associated with More Medical Interventions and Longer Hospital Stays without Affecting Outcome. Front Neurol. 2017; 8:184. Hong D, Stradling D, Dastur CK, Akbari Y, Groysman L, Al-Khoury L, Chen J, Small SL, Yu W. PMID: 28515710; PMCID: PMC5413489.

View in: PubMed Mentions: 4
Neural Correlates of Consciousness at Near-Electrocerebral Silence in an Asphyxial Cardiac Arrest Model. Brain Connect. 2017 04; 7(3):172-181. Lee DE, Lee LG, Siu D, Bazrafkan AK, Farahabadi MH, Dinh TJ, Orellana J, Xiong W, Lopour BA, Akbari Y. PMID: 28398813; PMCID: PMC5399737.

View in: PubMed Mentions: 8 Fields:
Bra Brain Neu Neurology
Translation:Animals Cells
Cerebral blood flow is decoupled from blood pressure and linked to EEG bursting after resuscitation from cardiac arrest. Biomed Opt Express. 2016 Nov 01; 7(11):4660-4673. Crouzet C, Wilson RH, Bazrafkan A, Farahabadi MH, Lee D, Alcocer J, Tromberg BJ, Choi B, Akbari Y. PMID: 27896005; PMCID: PMC5119605.

View in: PubMed Mentions: 17
Band specific changes in thalamocortical synchrony in field potentials after cardiac arrest induced global hypoxia. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:7112-5. Maybhate A, Chen C, Akbari Y, Sherman DL, Shen K, Jia X, Thakor NV. PMID: 24111384.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering
Translation:Animals
A new generation of therapeutic hypothermia: using a warm syringe to cool. Crit Care Med. 2011 Nov; 39(11):2558-9. Akbari Y, Geocadin RG. PMID: 22005225.

View in: PubMed Mentions: Fields:
Cri Critical Care
Translation:Animals
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Gen Physiol. 2008 Aug; 132(2):i1. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18663130.

View in: PubMed Mentions: 12 Fields:
Phy Physiology
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30; 181(7):1107-16. Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM. PMID: 18591429; PMCID: PMC2442205.

View in: PubMed Mentions: 134 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May; 26(5):645-54. Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. PMID: 15708439.

View in: PubMed Mentions: 119 Fields:
Ger Geriatrics Neu Neurology Phy Physiology
Translation:Humans Animals
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1145-52. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. PMID: 15336962.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals Cells
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003 Jul 31; 39(3):409-21. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. PMID: 12895417.

View in: PubMed Mentions: 1845 Fields:
Neu Neurology
Translation:Humans Animals Cells
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4697-702. Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. PMID: 11917117; PMCID: PMC123710.

View in: PubMed Mentions: 95 Fields:
Sci Science
Translation:Animals Cells
Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol. 2000 May 15; 149(4):793-8. Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. PMID: 10811821; PMCID: PMC2174559.

View in: PubMed Mentions: 115 Fields:
Cel Cell Biology
Translation:Animals Cells