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Andrea J. Tenner

Title(s)Professor, Molecular Biology & Biochemistry
Phone(949) 824-3268, 3266
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    Collapse Research 
    Collapse Research Activities and Funding
    Modulating Polarization of Glial Cells in AD mouse models by a Complement Receptor Antagonist
    NIH/NIA R21AG061746Feb 1, 2019 - Nov 30, 2020
    Role: Principal Investigator
    Defining the Mechanistic Link between C5aR1 signaling and cognitive loss in Alzheimer's diseases
    NIH/NIA R01AG060148Sep 15, 2018 - May 31, 2022
    Role: Principal Investigator
    UC Irvine AD Translational Center for Disease Model Resources
    NIH/NIA U54AG054349Sep 15, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Inflammation in Innate and Adaptive Immune Mechanisms
    NIH/NIAID R13AI102527Sep 1, 2012 - Aug 31, 2013
    Role: Principal Investigator
    Infection, Inflammation, Immunity
    NIH/NIAID R13AI096809Jun 15, 2011 - May 31, 2012
    Role: Principal Investigator
    Complement and Inflammatory Factors in AD Pathogenesis
    NIH/NINDS R01NS035144Feb 1, 1997 - Apr 30, 2015
    Role: Principal Investigator
    Interaction of Clq on Phagocytic Cells
    NIH/NIAID R01AI041090Jul 1, 1996 - Mar 31, 2012
    Role: Principal Investigator
    INTERACTIONS OF C1Q WITH PHAGOCYTIC CELLS
    NIH/NIAID R01AI027168Feb 1, 1989 - Jan 31, 1993
    Role: Co-Principal Investigator
    Training in the Neurobiology of Aging and Alzheimer's Disease
    NIH/NIA T32AG000096Sep 29, 1982 - Apr 30, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tenner AJ, Atkinson JP, Holers VM. Preface to the Special issue for the 27th International complement workshop. Mol Immunol. 2018 10; 102:1-2. PMID: 30060927.
      View in: PubMed
    2. Tenner AJ, Stevens B, Woodruff TM. New tricks for an ancient system: Physiological and pathological roles of complement in the CNS. Mol Immunol. 2018 10; 102:3-13. PMID: 29958698.
      View in: PubMed
    3. Johansson JU, Brubaker WD, Javitz H, Bergen AW, Nishita D, Trigunaite A, Crane A, Ceballos J, Mastroeni D, Tenner AJ, Sabbagh M, Rogers J. Peripheral complement interactions with amyloid ß peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement. 2018 11; 14(11):1438-1449. PMID: 29792870.
      View in: PubMed
    4. Kim YK, Chu SH, Hsieh JY, Kamoku CM, Tenner AJ, Liu WF, Wang SW. Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses. Adv Healthc Mater. 2017 Dec; 6(24). PMID: 29083540.
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    5. Hernandez MX, Jiang S, Cole TA, Chu SH, Fonseca MI, Fang MJ, Hohsfield LA, Torres MD, Green KN, Wetsel RA, Mortazavi A, Tenner AJ. Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss. Mol Neurodegener. 2017 09 18; 12(1):66. PMID: 28923083.
      View in: PubMed
    6. Crane A, Brubaker WD, Johansson JU, Trigunaite A, Ceballos J, Bradt B, Glavis-Bloom C, Wallace TL, Tenner AJ, Rogers J. Peripheral complement interactions with amyloid ß peptide in Alzheimer's disease: 2. Relationship to amyloid ß immunotherapy. Alzheimers Dement. 2018 02; 14(2):243-252. PMID: 28755839.
      View in: PubMed
    7. Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ. C1q: A fresh look upon an old molecule. Mol Immunol. 2017 09; 89:73-83. PMID: 28601358.
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    8. Fonseca MI, Chu SH, Hernandez MX, Fang MJ, Modarresi L, Selvan P, MacGregor GR, Tenner AJ. Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. J Neuroinflammation. 2017 03 06; 14(1):48. PMID: 28264694.
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    9. Hernandez MX, Namiranian P, Nguyen E, Fonseca MI, Tenner AJ. C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta. ASN Neuro. 2017 Feb; 9(1):1759091416687871. PMID: 28078911.
      View in: PubMed
    10. Fujita T, Wakamiya N, Tenner AJ. Preface to the Special Issue for the XXVI International Complement Workshop. Immunobiology. 2016 10; 221(10):1035-6. PMID: 27402136.
      View in: PubMed
    11. Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, Clarke EV, Rogers J, Atkinson JP, Tenner AJ. Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function. PLoS One. 2016; 11(2):e0149792. PMID: 26914463.
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    12. Linnartz-Gerlach B, Schuy C, Shahraz A, Tenner AJ, Neumann H. Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron Co-Culture System. Glia. 2016 Jan; 64(1):35-47. PMID: 26257016.
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    13. Rice RA, Spangenberg EE, Yamate-Morgan H, Lee RJ, Arora RP, Hernandez MX, Tenner AJ, West BL, Green KN. Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus. J Neurosci. 2015 Jul 08; 35(27):9977-89. PMID: 26156998.
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    14. Woodruff TM, Tenner AJ. A Commentary On: "NF?B-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR. Front Immunol. 2015; 6:220. PMID: 25999955.
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    15. Clarke EV, Weist BM, Walsh CM, Tenner AJ. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 2015 Jan; 97(1):147-60. PMID: 25381385.
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    16. Clarke EV, Tenner AJ. Complement modulation of T cell immune responses during homeostasis and disease. J Leukoc Biol. 2014 Nov; 96(5):745-56. PMID: 25210145.
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    17. Clarke EV, Benoit ME, Tenner AJ. Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation- A Short Protocol. Bio Protoc. 2013 Dec 05; 3(23). PMID: 27081666.
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    18. Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB. Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. 2014 Apr; 16(4):580-95. PMID: 24245749.
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    19. Benoit ME, Clarke EV, Tenner AJ. C1q Binding to and Uptake of Apoptotic Lymphocytes by Human Monocyte-derived Macrophages. Bio Protoc. 2013 Sep 05; 3(17). PMID: 27064237.
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    20. Fonseca MI, McGuire SO, Counts SE, Tenner AJ. Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. J Neuroinflammation. 2013 Feb 08; 10:25. PMID: 23394121.
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    21. Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-ß neurotoxicity. J Biol Chem. 2013 Jan 04; 288(1):654-65. PMID: 23150673.
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    22. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012 Jul 23; 9:179. PMID: 22824372.
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    23. Benoit ME, Clarke EV, Morgado P, Fraser DA, Tenner AJ. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol. 2012 Jun 01; 188(11):5682-93. PMID: 22523386.
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    24. Linnartz B, Kopatz J, Tenner AJ, Neumann H. Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia. J Neurosci. 2012 Jan 18; 32(3):946-52. PMID: 22262892.
      View in: PubMed
    25. Veerhuis R, Nielsen HM, Tenner AJ. Complement in the brain. Mol Immunol. 2011 Aug; 48(14):1592-603. PMID: 21546088.
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    26. Benoit ME, Tenner AJ. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci. 2011 Mar 02; 31(9):3459-69. PMID: 21368058.
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    27. Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner AJ. Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation. 2011 Jan 15; 8(1):4. PMID: 21235806.
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    28. Fraser DA, Tenner AJ. Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages. J Immunol. 2010 Oct 01; 185(7):3932-9. PMID: 20833838.
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    29. Zekavat G, Mozaffari R, Arias VJ, Rostami SY, Badkerhanian A, Tenner AJ, Nichols KE, Naji A, Noorchashm H. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics. 2010 Jun; 62(6):397-407. PMID: 20387063.
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    30. Ager RR, Fonseca MI, Chu SH, Sanderson SD, Taylor SM, Woodruff TM, Tenner AJ. Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J Neurochem. 2010 Apr; 113(2):389-401. PMID: 20132482.
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    31. Fraser DA, Pisalyaput K, Tenner AJ. C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production. J Neurochem. 2010 Feb; 112(3):733-43. PMID: 19919576.
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    32. Fraser DA, Laust AK, Nelson EL, Tenner AJ. C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol. 2009 Nov 15; 183(10):6175-85. PMID: 19864605.
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    33. Woodruff TM, Ager RR, Tenner AJ, Noakes PG, Taylor SM. The role of the complement system and the activation fragment C5a in the central nervous system. Neuromolecular Med. 2010 Jun; 12(2):179-92. PMID: 19763906.
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    34. Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM, Taylor SM, Woodruff TM, Tenner AJ. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15; 183(2):1375-83. PMID: 19561098.
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    35. Klos A, Tenner AJ, Johswich KO, Ager RR, Reis ES, Köhl J. The role of the anaphylatoxins in health and disease. Mol Immunol. 2009 Sep; 46(14):2753-66. PMID: 19477527.
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    36. Alexander JJ, Anderson AJ, Barnum SR, Stevens B, Tenner AJ. The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration. J Neurochem. 2008 Dec; 107(5):1169-87. PMID: 18786171.
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    37. Zhou J, Fonseca MI, Pisalyaput K, Tenner AJ. Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease. J Neurochem. 2008 Sep; 106(5):2080-92. PMID: 18624920.
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    38. Lillis AP, Greenlee MC, Mikhailenko I, Pizzo SV, Tenner AJ, Strickland DK, Bohlson SS. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol. 2008 Jul 01; 181(1):364-73. PMID: 18566402.
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    39. Li M, Ager RR, Fraser DA, Tjokro NO, Tenner AJ. Development of a humanized C1q A chain knock-in mouse: assessment of antibody independent beta-amyloid induced complement activation. Mol Immunol. 2008 Jun; 45(11):3244-52. PMID: 18400300.
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    40. Fraser DA, Tenner AJ. Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules. Curr Drug Targets. 2008 Feb; 9(2):113-22. PMID: 18288962.
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    41. Pisalyaput K, Tenner AJ. Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms. J Neurochem. 2008 Feb; 104(3):696-707. PMID: 17986223.
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    42. Fraser DA, Arora M, Bohlson SS, Lozano E, Tenner AJ. Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes. J Biol Chem. 2007 Mar 09; 282(10):7360-7. PMID: 17209050.
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    43. Bohlson SS, Fraser DA, Tenner AJ. Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol Immunol. 2007 Jan; 44(1-3):33-43. PMID: 16908067.
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    44. Fraser DA, Bohlson SS, Jasinskiene N, Rawal N, Palmarini G, Ruiz S, Rochford R, Tenner AJ. C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J Leukoc Biol. 2006 Jul; 80(1):107-16. PMID: 16617157.
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    45. Tenner AJ, Fonseca MI. The double-edged flower: roles of complement protein C1q in neurodegenerative diseases. Adv Exp Med Biol. 2006; 586:153-76. PMID: 16893071.
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    46. Zhou J, Fonseca MI, Kayed R, Hernandez I, Webster SD, Yazan O, Cribbs DH, Glabe CG, Tenner AJ. Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation. 2005 Dec 07; 2:28. PMID: 16332263.
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    47. Osmers I, Szalai AJ, Tenner AJ, Barnum SR. Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated. Mol Immunol. 2006 Apr; 43(10):1722-5. PMID: 16310250.
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    48. Bohlson SS, Silva R, Fonseca MI, Tenner AJ. CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 2005 Jul 15; 175(2):1239-47. PMID: 16002728.
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    49. Zhang M, Bohlson SS, Dy M, Tenner AJ. Modulated interaction of the ERM protein, moesin, with CD93. Immunology. 2005 May; 115(1):63-73. PMID: 15819698.
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    50. Fan R, Tenner AJ. Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation. J Neuroinflammation. 2005 Jan 10; 2(1):1. PMID: 15642121.
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    51. Li M, Pisalyaput K, Galvan M, Tenner AJ. Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microglia-mediated neurotoxicity. J Neurochem. 2004 Nov; 91(3):623-33. PMID: 15485493.
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    52. Bohlson SS, Zhang M, Ortiz CE, Tenner AJ. CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. J Leukoc Biol. 2005 Jan; 77(1):80-9. PMID: 15459234.
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    53. Fonseca MI, Zhou J, Botto M, Tenner AJ. Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci. 2004 Jul 21; 24(29):6457-65. PMID: 15269255.
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    54. Tenner AJ. Influence of innate immune responses on autoimmunity. Autoimmunity. 2004 Mar; 37(2):83-4. PMID: 15293877.
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    55. Fan R, Tenner AJ. Complement C1q expression induced by Abeta in rat hippocampal organotypic slice cultures. Exp Neurol. 2004 Feb; 185(2):241-53. PMID: 14736505.
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    56. Fonseca MI, Kawas CH, Troncoso JC, Tenner AJ. Neuronal localization of C1q in preclinical Alzheimer's disease. Neurobiol Dis. 2004 Feb; 15(1):40-6. PMID: 14751769.
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    57. Park M, Tenner AJ. Cell surface expression of C1qRP/CD93 is stabilized by O-glycosylation. J Cell Physiol. 2003 Sep; 196(3):512-22. PMID: 12891708.
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    58. Maruyama H, Galvan M, Waffarn F, Tenner AJ. Human cord blood leukocyte innate immune responses to defense collagens. Pediatr Res. 2003 Nov; 54(5):724-31. PMID: 12904598.
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    59. Danet GH, Luongo JL, Butler G, Lu MM, Tenner AJ, Simon MC, Bonnet DA. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10441-5. PMID: 12140365.
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    60. Tenner AJ. Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events. Neurobiol Aging. 2001 Nov-Dec; 22(6):849-61. PMID: 11754992.
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    61. Fonseca MI, Carpenter PM, Park M, Palmarini G, Nelson EL, Tenner AJ. C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue. J Leukoc Biol. 2001 Nov; 70(5):793-800. PMID: 11698500.
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    62. Jack DL, Read RC, Tenner AJ, Frosch M, Turner MW, Klein NJ. Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. J Infect Dis. 2001 Nov 01; 184(9):1152-62. PMID: 11598838.
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    63. Arora M, Munoz E, Tenner AJ. Identification of a site on mannan-binding lectin critical for enhancement of phagocytosis. J Biol Chem. 2001 Nov 16; 276(46):43087-94. PMID: 11533031.
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    64. Webster SD, Galvan MD, Ferran E, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J Immunol. 2001 Jun 15; 166(12):7496-503. PMID: 11390503.
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    65. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001 Apr; 8(2):252-65. PMID: 11300721.
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    66. Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001 Apr; 158(4):1345-54. PMID: 11290552.
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    67. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner AJ, Tomiyama Y, Matsuzawa Y. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000 Sep 01; 96(5):1723-32. PMID: 10961870.
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    68. Eggleton P, Tenner AJ, Reid KB. C1q receptors. Clin Exp Immunol. 2000 Jun; 120(3):406-12. PMID: 10844516.
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    69. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Exp Neurol. 2000 May; 163(1):111-22. PMID: 10785449.
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    70. Kim TS, Park M, Nepomuceno RR, Palmarini G, Winokur S, Cotman CA, Bengtsson U, Tenner AJ. Characterization of the murine homolog of C1qR(P): identical cellular expression pattern, chromosomal location and functional activity of the human and murine C1qR(P). Mol Immunol. 2000 May; 37(7):377-89. PMID: 11074255.
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    71. Webster SD, Park M, Fonseca MI, Tenner AJ. Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis. J Leukoc Biol. 2000 Jan; 67(1):109-16. PMID: 10648005.
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    72. Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol. 2000 Jan; 161(1):127-38. PMID: 10683279.
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    73. Ruiz S, Henschen-Edman AH, Nagase H, Tenner AJ. Digestion of C1q collagen-like domain with MMPs-1,-2,-3, and -9 further defines the sequence involved in the stimulation of neutrophil superoxide production. J Leukoc Biol. 1999 Sep; 66(3):416-22. PMID: 10496311.
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    74. Huang J, Kim LJ, Mealey R, Marsh HC, Zhang Y, Tenner AJ, Connolly ES, Pinsky DJ. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science. 1999 Jul 23; 285(5427):595-9. PMID: 10417391.
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    75. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Exp Neurol. 1999 Jun; 157(2):277-88. PMID: 10364440.
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    76. Webster SD, Tenner AJ, Poulos TL, Cribbs DH. The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation. Neurobiol Aging. 1999 May-Jun; 20(3):297-304. PMID: 10588577.
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    77. Nepomuceno RR, Ruiz S, Park M, Tenner AJ. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. J Immunol. 1999 Mar 15; 162(6):3583-9. PMID: 10092817.
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    78. Tenner AJ. Membrane receptors for soluble defense collagens. Curr Opin Immunol. 1999 Feb; 11(1):34-41. PMID: 10047541.
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    79. Eggleton P, Reid KB, Tenner AJ. C1q--how many functions? How many receptors? Trends Cell Biol. 1998 Nov; 8(11):428-31. PMID: 9854308.
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    80. Tenner AJ. C1q receptors: regulating specific functions of phagocytic cells. Immunobiology. 1998 Aug; 199(2):250-64. PMID: 9777410.
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    81. Nepomuceno RR, Tenner AJ. C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J Immunol. 1998 Feb 15; 160(4):1929-35. PMID: 9469455.
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    82. Cribbs DH, Velazquez P, Soreghan B, Glabe CG, Tenner AJ. Complement activation by cross-linked truncated and chimeric full-length beta-amyloid. Neuroreport. 1997 Nov 10; 8(16):3457-62. PMID: 9427307.
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    83. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 07; 774(1-2):35-43. PMID: 9452189.
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    84. Webster S, Lue LF, Brachova L, Tenner AJ, McGeer PL, Terai K, Walker DG, Bradt B, Cooper NR, Rogers J. Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease. Neurobiol Aging. 1997 Jul-Aug; 18(4):415-21. PMID: 9330973.
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    85. Nepomuceno RR, Henschen-Edman AH, Burgess WH, Tenner AJ. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity. 1997 Feb; 6(2):119-29. PMID: 9047234.
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    86. Velazquez P, Cribbs DH, Poulos TL, Tenner AJ. Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis. Nat Med. 1997 Jan; 3(1):77-9. PMID: 8986745.
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    87. Cotman CW, Tenner AJ, Cummings BJ. beta-Amyloid converts an acute phase injury response to chronic injury responses. Neurobiol Aging. 1996 Sep-Oct; 17(5):723-31. PMID: 8892345.
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    88. Afagh A, Cummings BJ, Cribbs DH, Cotman CW, Tenner AJ. Localization and cell association of C1q in Alzheimer's disease brain. Exp Neurol. 1996 Mar; 138(1):22-32. PMID: 8593893.
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    89. Ruiz S, Henschen-Edman AH, Tenner AJ. Localization of the site on the complement component C1q required for the stimulation of neutrophil superoxide production. J Biol Chem. 1995 Dec 22; 270(51):30627-34. PMID: 8530499.
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    90. Tenner AJ, Robinson SL, Ezekowitz RA. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor. Immunity. 1995 Oct; 3(4):485-93. PMID: 7584139.
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    91. Goodman EB, Anderson DC, Tenner AJ. C1q triggers neutrophil superoxide production by a unique CD18-dependent mechanism. J Leukoc Biol. 1995 Aug; 58(2):168-76. PMID: 7643012.
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    92. Korotzer AR, Watt J, Cribbs D, Tenner AJ, Burdick D, Glabe C, Cotman CW. Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia. Exp Neurol. 1995 Aug; 134(2):214-21. PMID: 7556541.
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    93. Smyth MD, Cribbs DH, Tenner AJ, Shankle WR, Dick M, Kesslak JP, Cotman CW. Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state. Neurobiol Aging. 1994 Sep-Oct; 15(5):609-14. PMID: 7824052.
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    94. Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol. 1994 May 15; 152(10):5050-9. PMID: 8176223.
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    95. Guan E, Robinson SL, Goodman EB, Tenner AJ. Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J Immunol. 1994 Apr 15; 152(8):4005-16. PMID: 8144968.
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    96. Tenner AJ. Functional aspects of the C1q receptors. Behring Inst Mitt. 1993 Dec; (93):241-53. PMID: 8172573.
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    97. Goodman EB, Tenner AJ. Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways. J Immunol. 1992 Jun 15; 148(12):3920-8. PMID: 1318335.
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    98. Schweinle JE, Ezekowitz RA, Tenner AJ, Kuhlman M, Joiner KA. Human mannose-binding protein activates the alternative complement pathway and enhances serum bactericidal activity on a mannose-rich isolate of Salmonella. J Clin Invest. 1989 Dec; 84(6):1821-9. PMID: 2592561.
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    99. Rimoldi MT, Tenner AJ, Bobak DA, Joiner KA. Complement component C1q enhances invasion of human mononuclear phagocytes and fibroblasts by Trypanosoma cruzi trypomastigotes. J Clin Invest. 1989 Dec; 84(6):1982-9. PMID: 2687332.
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    100. Tenner AJ, Robinson SL, Borchelt J, Wright JR. Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis. J Biol Chem. 1989 Aug 15; 264(23):13923-8. PMID: 2788165.
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    101. Tenner AJ. C1q interactions with cell surface receptors. Behring Inst Mitt. 1989 Jul; (84):220-9. PMID: 2679535.
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    102. Bobak DA, Frank MM, Tenner AJ. C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes. Eur J Immunol. 1988 Dec; 18(12):2001-7. PMID: 2975599.
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    103. Rimoldi MT, Tenner AJ, Bobak DA, Joiner KA. Enhanced invasion of mononuclear phagocytes by serum-treated Trypanosoma cruzi is due to Clq. Mem Inst Oswaldo Cruz. 1988 Nov; 83 Suppl 1:456-8. PMID: 3075688.
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    104. Bobak DA, Gaither TA, Frank MM, Tenner AJ. Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages. J Immunol. 1987 Feb 15; 138(4):1150-6. PMID: 3492544.
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    105. Bobak DA, Frank MM, Tenner AJ. Characterization of C1q receptor expression on human phagocytic cells: effects of PDBu and fMLP. J Immunol. 1986 Jun 15; 136(12):4604-10. PMID: 3486907.
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    106. Tenner AJ, Ziccardi RJ, Cooper NR. Antibody-independent C1 activation by E. coli. J Immunol. 1984 Aug; 133(2):886-91. PMID: 6376630.
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    107. Tenner AJ, Cooper NR. Stimulation of a human polymorphonuclear leukocyte oxidative response by the C1q subunit of the first complement component. J Immunol. 1982 Jun; 128(6):2547-52. PMID: 6281333.
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