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Tenner, Andrea J.

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMolecular Biology & Biochem
Address2228 McGaugh Hall
Zot 3900
CA 92697
Phone(949) 824-3268, 3266
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    Collapse Research 
    Collapse Research Activities and Funding
    UC Irvine AD Translational Center for Disease Model Resources
    NIH/NIA U54AG054349Sep 15, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Inflammation in Innate and Adaptive Immune Mechanisms
    NIH/NIAID R13AI102527Sep 1, 2012 - Aug 31, 2013
    Role: Principal Investigator
    Infection, Inflammation, Immunity
    NIH/NIAID R13AI096809Jun 15, 2011 - May 31, 2012
    Role: Principal Investigator
    Complement and Inflammatory Factors in AD Pathogenesis
    NIH/NINDS R01NS035144Feb 1, 1997 - Apr 30, 2015
    Role: Principal Investigator
    Interaction of Clq on Phagocytic Cells
    NIH/NIAID R01AI041090Jul 1, 1996 - Mar 31, 2012
    Role: Principal Investigator
    INTERACTIONS OF C1Q WITH PHAGOCYTIC CELLS
    NIH/NIAID R01AI027168Feb 1, 1989 - Jan 31, 1993
    Role: Co-Principal Investigator
    Training in the Neurobiology of Aging
    NIH/NIA T32AG000096Sep 29, 1982 - Apr 30, 2019
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Johansson JU, Brubaker WD, Javitz H, Bergen AW, Nishita D, Trigunaite A, Crane A, Ceballos J, Mastroeni D, Tenner A, Sabbagh M, Rogers J. Peripheral complement interactions with amyloid ß peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement. 2018 May 21. PMID: 29792870.
      View in: PubMed
    2. Kim YK, Chu SH, Hsieh JY, Kamoku CM, Tenner A, Liu WF, Wang SW. Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses. Adv Healthc Mater. 2017 Dec; 6(24). PMID: 29083540.
      View in: PubMed
    3. Hernandez MX, Jiang S, Cole TA, Chu SH, Fonseca MI, Fang MJ, Hohsfield LA, Torres MD, Green KN, Wetsel RA, Mortazavi A, Tenner A. Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss. Mol Neurodegener. 2017 09 18; 12(1):66. PMID: 28923083.
      View in: PubMed
    4. Crane A, Brubaker WD, Johansson JU, Trigunaite A, Ceballos J, Bradt B, Glavis-Bloom C, Wallace TL, Tenner A, Rogers J. Peripheral complement interactions with amyloid ß peptide in Alzheimer's disease: 2. Relationship to amyloid ß immunotherapy. Alzheimers Dement. 2018 Feb; 14(2):243-252. PMID: 28755839.
      View in: PubMed
    5. Fonseca MI, Chu SH, Hernandez MX, Fang MJ, Modarresi L, Selvan P, MacGregor GR, Tenner A. Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. J Neuroinflammation. 2017 Mar 06; 14(1):48. PMID: 28264694.
      View in: PubMed
    6. Hernandez MX, Namiranian P, Nguyen E, Fonseca MI, Tenner A. C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta. ASN Neuro. 2017 Feb; 9(1):1759091416687871. PMID: 28078911.
      View in: PubMed
    7. Fujita T, Wakamiya N, Tenner A. Preface to the Special Issue for the XXVI International Complement Workshop. Immunobiology. 2016 10; 221(10):1035-6. PMID: 27402136.
      View in: PubMed
    8. Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, Clarke EV, Rogers J, Atkinson JP, Tenner A. Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function. PLoS One. 2016; 11(2):e0149792. PMID: 26914463; PMCID: PMC4767815.
    9. Linnartz-Gerlach B, Schuy C, Shahraz A, Tenner A, Neumann H. Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron Co-Culture System. Glia. 2016 Jan; 64(1):35-47. PMID: 26257016; PMCID: PMC4715670 [Available on 01/01/17].
    10. Rice RA, Spangenberg EE, Yamate-Morgan H, Lee RJ, Arora RP, Hernandez MX, Tenner A, West BL, Green KN. Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus. J Neurosci. 2015 Jul 08; 35(27):9977-89. PMID: 26156998; PMCID: PMC4495246.
    11. Woodruff TM, Tenner A. A Commentary On: "NF?B-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR. Front Immunol. 2015; 6:220. PMID: 25999955; PMCID: PMC4423305.
    12. Clarke EV, Weist BM, Walsh CM, Tenner A. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 2015 Jan; 97(1):147-60. PMID: 25381385; PMCID: PMC4377823.
    13. Clarke EV, Tenner A. Complement modulation of T cell immune responses during homeostasis and disease. J Leukoc Biol. 2014 Nov; 96(5):745-56. PMID: 25210145; PMCID: PMC4197570.
    14. Clarke EV, Benoit ME, Tenner A. Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation- A Short Protocol. Bio Protoc. 2013 Dec 05; 3(23). PMID: 27081666.
      View in: PubMed
    15. Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner A, Lodoen MB. Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. 2014 Apr; 16(4):580-95. PMID: 24245749; PMCID: PMC4141879.
    16. Benoit ME, Clarke EV, Tenner A. C1q Binding to and Uptake of Apoptotic Lymphocytes by Human Monocyte-derived Macrophages. Bio Protoc. 2013 Sep 05; 3(17). PMID: 27064237.
      View in: PubMed
    17. Fonseca MI, McGuire SO, Counts SE, Tenner A. Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. J Neuroinflammation. 2013 Feb 08; 10:25. PMID: 23394121; PMCID: PMC3605123.
    18. Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner A. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-ß neurotoxicity. J Biol Chem. 2013 Jan 04; 288(1):654-65. PMID: 23150673; PMCID: PMC3537064.
    19. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner A, Cotman CW. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012 Jul 23; 9:179. PMID: 22824372; PMCID: PMC3419089.
    20. Benoit ME, Clarke EV, Morgado P, Fraser DA, Tenner A. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol. 2012 Jun 01; 188(11):5682-93. PMID: 22523386; PMCID: PMC3358549.
    21. Linnartz B, Kopatz J, Tenner A, Neumann H. Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia. J Neurosci. 2012 Jan 18; 32(3):946-52. PMID: 22262892; PMCID: PMC4037907.
    22. Benoit ME, Tenner A. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci. 2011 Mar 02; 31(9):3459-69. PMID: 21368058; PMCID: PMC3080046.
    23. Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner A. Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease. J Neuroinflammation. 2011 Jan 15; 8(1):4. PMID: 21235806; PMCID: PMC3033336.
    24. Fraser DA, Tenner A. Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages. J Immunol. 2010 Oct 01; 185(7):3932-9. PMID: 20833838; PMCID: PMC3334294.
    25. Zekavat G, Mozaffari R, Arias VJ, Rostami SY, Badkerhanian A, Tenner A, Nichols KE, Naji A, Noorchashm H. A novel CD93 polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+ iNKT cell deficient state. Immunogenetics. 2010 Jun; 62(6):397-407. PMID: 20387063; PMCID: PMC2875467.
    26. Ager RR, Fonseca MI, Chu SH, Sanderson SD, Taylor SM, Woodruff TM, Tenner A. Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease. J Neurochem. 2010 Apr; 113(2):389-401. PMID: 20132482; PMCID: PMC2921960.
    27. Fraser DA, Pisalyaput K, Tenner A. C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production. J Neurochem. 2010 Feb; 112(3):733-43. PMID: 19919576; PMCID: PMC2809134.
    28. Fraser DA, Laust AK, Nelson EL, Tenner A. C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol. 2009 Nov 15; 183(10):6175-85. PMID: 19864605; PMCID: PMC2843563.
    29. Woodruff TM, Ager RR, Tenner A, Noakes PG, Taylor SM. The role of the complement system and the activation fragment C5a in the central nervous system. Neuromolecular Med. 2010 Jun; 12(2):179-92. PMID: 19763906.
      View in: PubMed
    30. Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM, Taylor SM, Woodruff TM, Tenner A. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15; 183(2):1375-83. PMID: 19561098; PMCID: PMC4067320.
    31. Zhou J, Fonseca MI, Pisalyaput K, Tenner A. Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease. J Neurochem. 2008 Sep; 106(5):2080-92. PMID: 18624920; PMCID: PMC2574638.
    32. Lillis AP, Greenlee MC, Mikhailenko I, Pizzo SV, Tenner A, Strickland DK, Bohlson SS. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol. 2008 Jul 01; 181(1):364-73. PMID: 18566402; PMCID: PMC2663906.
    33. Li M, Ager RR, Fraser DA, Tjokro NO, Tenner A. Development of a humanized C1q A chain knock-in mouse: assessment of antibody independent beta-amyloid induced complement activation. Mol Immunol. 2008 Jun; 45(11):3244-52. PMID: 18400300; PMCID: PMC2453780.
    34. Pisalyaput K, Tenner A. Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms. J Neurochem. 2008 Feb; 104(3):696-707. PMID: 17986223.
      View in: PubMed
    35. Fraser DA, Arora M, Bohlson SS, Lozano E, Tenner A. Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes. J Biol Chem. 2007 Mar 09; 282(10):7360-7. PMID: 17209050.
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    36. Bohlson SS, Fraser DA, Tenner A. Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Mol Immunol. 2007 Jan; 44(1-3):33-43. PMID: 16908067.
      View in: PubMed
    37. Fraser DA, Bohlson SS, Jasinskiene N, Rawal N, Palmarini G, Ruiz S, Rochford R, Tenner A. C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J Leukoc Biol. 2006 Jul; 80(1):107-16. PMID: 16617157.
      View in: PubMed
    38. Tenner A, Fonseca MI. The double-edged flower: roles of complement protein C1q in neurodegenerative diseases. Adv Exp Med Biol. 2006; 586:153-76. PMID: 16893071.
      View in: PubMed
    39. Zhou J, Fonseca MI, Kayed R, Hernandez I, Webster SD, Yazan O, Cribbs DH, Glabe CG, Tenner A. Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation. 2005 Dec 07; 2:28. PMID: 16332263; PMCID: PMC1326209.
    40. Bohlson SS, Silva R, Fonseca MI, Tenner A. CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol. 2005 Jul 15; 175(2):1239-47. PMID: 16002728.
      View in: PubMed
    41. Zhang M, Bohlson SS, Dy M, Tenner A. Modulated interaction of the ERM protein, moesin, with CD93. Immunology. 2005 May; 115(1):63-73. PMID: 15819698; PMCID: PMC1782122.
    42. Fan R, Tenner A. Differential regulation of Abeta42-induced neuronal C1q synthesis and microglial activation. J Neuroinflammation. 2005 Jan 10; 2(1):1. PMID: 15642121.
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    43. Bohlson SS, Zhang M, Ortiz CE, Tenner A. CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. J Leukoc Biol. 2005 Jan; 77(1):80-9. PMID: 15459234.
      View in: PubMed
    44. Fonseca MI, Zhou J, Botto M, Tenner A. Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease. J Neurosci. 2004 Jul 21; 24(29):6457-65. PMID: 15269255.
      View in: PubMed
    45. Tenner A. Influence of innate immune responses on autoimmunity. Autoimmunity. 2004 Mar; 37(2):83-4. PMID: 15293877.
      View in: PubMed
    46. Fan R, Tenner A. Complement C1q expression induced by Abeta in rat hippocampal organotypic slice cultures. Exp Neurol. 2004 Feb; 185(2):241-53. PMID: 14736505.
      View in: PubMed
    47. Fonseca MI, Kawas CH, Troncoso JC, Tenner A. Neuronal localization of C1q in preclinical Alzheimer's disease. Neurobiol Dis. 2004 Feb; 15(1):40-6. PMID: 14751769.
      View in: PubMed
    48. Park M, Tenner A. Cell surface expression of C1qRP/CD93 is stabilized by O-glycosylation. J Cell Physiol. 2003 Sep; 196(3):512-22. PMID: 12891708.
      View in: PubMed
    49. Maruyama H, Galvan M, Waffarn F, Tenner A. Human cord blood leukocyte innate immune responses to defense collagens. Pediatr Res. 2003 Nov; 54(5):724-31. PMID: 12904598.
      View in: PubMed
    50. Danet GH, Luongo JL, Butler G, Lu MM, Tenner A, Simon MC, Bonnet DA. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10441-5. PMID: 12140365; PMCID: PMC124933.
    51. Tenner A. Complement in Alzheimer's disease: opportunities for modulating protective and pathogenic events. Neurobiol Aging. 2001 Nov-Dec; 22(6):849-61. PMID: 11754992.
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    52. Fonseca MI, Carpenter PM, Park M, Palmarini G, Nelson EL, Tenner A. C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue. J Leukoc Biol. 2001 Nov; 70(5):793-800. PMID: 11698500.
      View in: PubMed
    53. Tenner A. Membrane receptors for soluble defense collagens. Curr Opin Immunol. 1999 Feb; 11(1):34-41. PMID: 10047541.
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