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Kitazawa, Masashi

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-1255
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    Collapse Research 
    Collapse Research Activities and Funding
    Environmental copper exposure and its impact on microglial Abeta clearance
    NIH/NIEHS R01ES024331Sep 19, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Pathogenic role of valosin-containing protein (VCP) in IBMPFD
    NIH/NIAMS R00AR054695Apr 9, 2012 - Mar 31, 2015
    Role: Principal Investigator
    Pathogenic Role of Abeta, tau and Inflammation in Inclusion Body Myositis
    NIH/NIAMS K99AR054695Aug 17, 2007 - Jul 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 Jun 06; e12791. PMID: 29877034.
      View in: PubMed
    2. Hsu HW, Bondy SC, Kitazawa M. Environmental and dietary exposure to copper and its cellular mechanisms linking to Alzheimer disease. Toxicol Sci. 2018 Feb 02. PMID: 29409005.
      View in: PubMed
    3. Zumkehr J, Rodriguez-Ortiz CJ, Medeiros R, Kitazawa M. Inflammatory Cytokine, IL-1ß, Regulates Glial Glutamate Transporter via microRNA-181a in vitro. J Alzheimers Dis. 2018; 63(3):965-975. PMID: 29710703.
      View in: PubMed
    4. Kitazawa M, Hatta T, Ogawa K, Fukuda E, Goshima N, Natsume T. Determination of Rate-Limiting Factor for Formation of Beta-Catenin Destruction Complexes Using Absolute Protein Quantification. J Proteome Res. 2017 Oct 06; 16(10):3576-3584. PMID: 28810742.
      View in: PubMed
    5. Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM. Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model. Front Syst Neurosci. 2017; 11:48. PMID: 28713250.
      View in: PubMed
    6. Vishwakarma R, Rosmi MS, Takahashi K, Wakamatsu Y, Yaakob Y, Araby MI, Kalita G, Kitazawa M, Tanemura M. Transfer free graphene growth on SiO2 substrate at 250?°C. Sci Rep. 2017 Mar 02; 7:43756. PMID: 28251997.
      View in: PubMed
    7. Kilian JG, Hsu HW, Mata K, Wolf FW, Kitazawa M. Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila. Neuroscience. 2017 Apr 21; 348:191-200. PMID: 28215745.
      View in: PubMed
    8. Kitazawa M, Hsu HW, Medeiros R. Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta. Toxicol Sci. 2016 07; 152(1):194-204. PMID: 27122238; PMCID: PMC4922545 [Available on 07/01/17].
    9. Rodriguez-Ortiz CJ, Flores JC, Valenzuela JA, Rodriguez GJ, Zumkehr J, Tran DN, Kimonis VE, Kitazawa M. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016 Jun; 186(6):1623-34. PMID: 27106764; PMCID: PMC4901142 [Available on 06/01/17].
    10. Lim SL, Rodriguez-Ortiz CJ, Kitazawa M. Infection, systemic inflammation, and Alzheimer's disease. Microbes Infect. 2015 Aug; 17(8):549-56. PMID: 25912134.
      View in: PubMed
    11. Zumkehr J, Rodriguez-Ortiz CJ, Cheng D, Kieu Z, Wai T, Hawkins C, Kilian J, Lim SL, Medeiros R, Kitazawa M. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiol Aging. 2015 Jul; 36(7):2260-2271. PMID: 25964214.
      View in: PubMed
    12. Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015; 43(3):893-903. PMID: 25125468; PMCID: PMC4319708.
    13. Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014 Apr 16; 82(2):380-97. PMID: 24742461; PMCID: PMC4161285.
    14. Rodriguez-Ortiz CJ, Baglietto-Vargas D, Martinez-Coria H, LaFerla FM, Kitazawa M. Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J Alzheimers Dis. 2014; 42(4):1229-38. PMID: 25024332.
      View in: PubMed
    15. Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. a7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014 Feb; 184(2):520-9. PMID: 24269557.
      View in: PubMed
    16. Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014 Feb; 62:407-15. PMID: 24176788.
      View in: PubMed
    17. Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15. PMID: 23747512; PMCID: PMC3730785.
    18. Kitazawa M. Circadian rhythms, metabolism, and insulin sensitivity: transcriptional networks in animal models. Curr Diab Rep. 2013 Apr; 13(2):223-8. PMID: 23266563.
      View in: PubMed
    19. Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM. Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May; 182(5):1780-9. PMID: 23506847; PMCID: PMC3644736.
    20. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. The homozygote VCP(R¹55H/R¹55H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One. 2012; 7(9):e46308. PMID: 23029473; PMCID: PMC3460820.
    21. Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012 Aug; 181(2):616-25. PMID: 22688056.
      View in: PubMed
    22. Kitazawa M, Medeiros R, Laferla FM. Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr Pharm Des. 2012; 18(8):1131-47. PMID: 22288400; PMCID: PMC4437619.
    23. Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal ß-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011 Dec 15; 187(12):6539-49. PMID: 22095718; PMCID: PMC4072218.
    24. Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011 Aug; 179(2):980-91. PMID: 21704011; PMCID: PMC3157199.
    25. Yamajuku D, Shibata Y, Kitazawa M, Katakura T, Urata H, Kojima T, Takayasu S, Nakata O, Hashimoto S. Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator. FEBS Lett. 2011 Jul 21; 585(14):2217-22. PMID: 21635892.
      View in: PubMed
    26. Kitazawa M, Nagano M, Masumoto KH, Shigeyoshi Y, Natsume T, Hashimoto S. Angiopoietin-like 2, a circadian gene, improves type 2 diabetes through potentiation of insulin sensitivity in mice adipocytes. Endocrinology. 2011 Jul; 152(7):2558-67. PMID: 21586562.
      View in: PubMed
    27. Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM. Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol. 2011 Jun; 178(6):2811-22. PMID: 21531375; PMCID: PMC3124234.
    28. Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace DC, Mukherjee J, Caiozzo V, Warman M, Kimonis VE. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One. 2010 Oct 05; 5(10). PMID: 20957154.
      View in: PubMed
    29. Yamajuku D, Shibata Y, Kitazawa M, Katakura T, Urata H, Kojima T, Nakata O, Hashimoto S. Identification of functional clock-controlled elements involved in differential timing of Per1 and Per2 transcription. Nucleic Acids Res. 2010 Dec; 38(22):7964-73. PMID: 20693532; PMCID: PMC3001056.
    30. Takeda S, Minakata S, Koike R, Kawahata I, Narita A, Kitazawa M, Ota M, Yamakuni T, Maéda Y, Nitanai Y. Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition. PLoS Biol. 2010 Jul 06; 8(7):e1000416. PMID: 20625546; PMCID: PMC2897767.
    31. Hasegawa T, Mikoda N, Kitazawa M, LaFerla FM. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One. 2010 Jan 20; 5(1):e8593. PMID: 20098691; PMCID: PMC2808336.
    32. Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010 Feb; 176(2):870-80. PMID: 20042680; PMCID: PMC2808092.
    33. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9. PMID: 19633196.
      View in: PubMed
    34. Kitazawa M, Vasilevko V, Cribbs DH, LaFerla FM. Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J Neurosci. 2009 May 13; 29(19):6132-41. PMID: 19439591; PMCID: PMC3049190.
    35. Kitazawa M, Cheng D, Laferla FM. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 2009 Mar; 108(6):1550-60. PMID: 19183260; PMCID: PMC4096128.
    36. Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW. Amyloid-ß protein impairs Ca2+ release and contractility in skeletal muscle. Neurobiol Aging. 2010 Dec; 31(12):2080-90. PMID: 19108934; PMCID: PMC2901770.
    37. Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Mol Brain. 2008 Oct 22; 1:12. PMID: 18945348; PMCID: PMC2584097.
    38. Kitazawa M, Trinh DN, LaFerla FM. Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta. Ann Neurol. 2008 Jul; 64(1):15-24. PMID: 18318434.
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    39. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33. PMID: 17978032.
      View in: PubMed
    40. Kitazawa M, Ohizumi Y, Oike Y, Hishinuma T, Hashimoto S. Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes. J Pharmacol Exp Ther. 2007 Dec; 323(3):787-93. PMID: 17804676.
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    41. Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006 Dec 22; 281(51):39413-23. PMID: 17056594.
      View in: PubMed
    42. Kitazawa M, Shibata Y, Hashimoto S, Ohizumi Y, Yamakuni T. Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts. J Biochem. 2006 Jun; 139(6):1083-8. PMID: 16788059.
      View in: PubMed
    43. Kitazawa M, Green KN, Caccamo A, LaFerla FM. Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol. 2006 Jun; 168(6):1986-97. PMID: 16723713; PMCID: PMC1606633.
    44. LaFerla FM, Kitazawa M. Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad. Neuron. 2005 Dec 08; 48(5):711-2. PMID: 16337907.
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    45. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Sep 28; 25(39):8843-53. PMID: 16192374.
      View in: PubMed
    46. Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology. 2005 Aug; 26(4):701-19. PMID: 16112328.
      View in: PubMed
    47. Sugarman MC, Kitazawa M, Baker M, Caiozzo VJ, Querfurth HW, LaFerla FM. Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model. Neurobiol Aging. 2006 Mar; 27(3):423-32. PMID: 15950323.
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    48. Kitazawa M, Yamakuni T, Song SY, Kato C, Tsuchiya R, Ishida M, Suzuki N, Adachi E, Iwashita S, Ueno S, Yanagihara N, Taoka M, Isobe T, Ohizumi Y. Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells. Biochem Biophys Res Commun. 2005 May 27; 331(1):181-6. PMID: 15845376.
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    49. Kitazawa M, Anantharam V, Yang Y, Hirata Y, Kanthasamy A, Kanthasamy AG. Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochem Pharmacol. 2005 Jan 01; 69(1):133-46. PMID: 15588722.
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    50. Latchoumycandane C, Anantharam V, Kitazawa M, Yang Y, Kanthasamy A, Kanthasamy AG. Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. J Pharmacol Exp Ther. 2005 Apr; 313(1):46-55. PMID: 15608081.
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    51. Kitazawa M, Yamasaki TR, LaFerla FM. Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann N Y Acad Sci. 2004 Dec; 1035:85-103. PMID: 15681802.
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    52. Tseng BP, Kitazawa M, LaFerla FM. Amyloid beta-peptide: the inside story. Curr Alzheimer Res. 2004 Nov; 1(4):231-9. PMID: 15975052.
      View in: PubMed
    53. Kitazawa M, Anantharam V, Kanthasamy A, Kanthasamy AG. Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology. 2004 Jun; 25(4):589-98. PMID: 15183012.
      View in: PubMed
    54. Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003 Dec; 24(8):1063-70. PMID: 14643377.
      View in: PubMed
    55. Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxid Redox Signal. 2003 Oct; 5(5):609-20. PMID: 14580317.
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    56. Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, Kanthasamy AG. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. Eur J Neurosci. 2003 Sep; 18(6):1387-401. PMID: 14511319.
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    57. Kitazawa M, Wagner JR, Kirby ML, Anantharam V, Kanthasamy AG. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. J Pharmacol Exp Ther. 2002 Jul; 302(1):26-35. PMID: 12065696.
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    58. Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG. Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci. 2002 Mar 01; 22(5):1738-51. PMID: 11880503.
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