Masashi Kitazawa

Title(s)Professor, Ctr For Occup & Environ Health
SchoolUC Irvine Joe C. Wen School of Population & Public Health
Address856 Health Sciences Quad
University of California, Irvine
Irvine CA 92697-3957
Phone(949) 824-1255
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of particulate matter-induced neurotoxicity and cognitive decline in mice
    NIH R21ES028496Sep 30, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Environmental copper exposure and its impact on microglial Abeta clearance
    NIH R01ES024331Sep 19, 2014 - Jun 30, 2020
    Role: Principal Investigator
    Pathogenic role of valosin-containing protein (VCP) in IBMPFD
    NIH R00AR054695Apr 9, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Pathogenic Role of Abeta, tau and Inflammation in Inclusion Body Myositis
    NIH K99AR054695Aug 17, 2007 - Jul 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells. J Nutr Biochem. 2023 10; 120:109413. Teafatiller T, Perez O, Kitazawa M, Agrawal A, Subramanian VS. PMID: 37423323.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model. Toxicol Sci. 2023 05 31; 193(2):175-191. Kilian JG, Mejias-Ortega M, Hsu HW, Herman DA, Vidal J, Arechavala RJ, Renusch S, Dalal H, Hasen I, Ting A, Rodriguez-Ortiz CJ, Lim SL, Lin X, Vu J, Saito T, Saido TC, Kleinman MT, Kitazawa M. PMID: 37074955; PMCID: PMC10230292.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    3. Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats. Clin Exp Pharmacol Physiol. 2023 03; 50(3):228-237. Rodriguez-Ortiz CJ, Thorwald MA, Rodriguez R, Mejias-Ortega M, Kieu Z, Maitra N, Hawkins C, Valenzuela J, Peng M, Nishiyama A, Ortiz RM, Kitazawa M. PMID: 36398458; PMCID: PMC9898104.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    4. Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells. Life Sci. 2022 Nov 01; 308:120944. Teafatiller T, Subramanian S, Marquez FE, Kitazawa M, Subramanian VS. PMID: 36096242.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    5. Calsyntenin-3 interacts with the sodium-dependent vitamin C transporter-2 to regulate vitamin C uptake. Int J Biol Macromol. 2021 Dec 01; 192:1178-1184. Subramanian VS, Teafatiller T, Vidal J, Gunaratne GS, Rodriguez-Ortiz CJ, Kitazawa M, Marchant JS. PMID: 34673103; PMCID: PMC9842108.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Effect of Lipopolysaccharide and TNFα on Neuronal Ascorbic Acid Uptake. Mediators Inflamm. 2021; 2021:4157132. Subramanian VS, Teafatiller T, Agrawal A, Kitazawa M, Marchant JS. PMID: 34285658; PMCID: PMC8275400.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. Assessing the activation/inhibition of tyrosine kinase-related pathways with a newly developed platform. Proteomics. 2021 08; 21(16):e2000251. Kagiwada H, Kiboku T, Matsuo H, Kitazawa M, Fukui K, Horimoto K. PMID: 34151541.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    8. Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology. Nat Commun. 2021 04 23; 12(1):2421. Baglietto-Vargas D, Forner S, Cai L, Martini AC, Trujillo-Estrada L, Swarup V, Nguyen MMT, Do Huynh K, Javonillo DI, Tran KM, Phan J, Jiang S, Kramár EA, Nuñez-Diaz C, Balderrama-Gutierrez G, Garcia F, Childs J, Rodriguez-Ortiz CJ, Garcia-Leon JA, Kitazawa M, Shahnawaz M, Matheos DP, Ma X, Da Cunha C, Walls KC, Ager RR, Soto C, Gutierrez A, Moreno-Gonzalez I, Mortazavi A, Tenner AJ, MacGregor GR, Wood M, Green KN, LaFerla FM. PMID: 33893290; PMCID: PMC8065162.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    9. Inflammatory Cytokine IL-1β Downregulates Endothelial LRP1 via MicroRNA-mediated Gene Silencing. Neuroscience. 2021 01 15; 453:69-80. Hsu HW, Rodriguez-Ortiz CJ, Zumkehr J, Kitazawa M. PMID: 33246059; PMCID: PMC7796931.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Potential use of lenvatinib for patients with unresectable hepatocellular carcinoma including after treatment with sorafenib: Real-world evidence and in vitro assessment via protein phosphorylation array. Oncotarget. 2020 Jun 30; 11(26):2531-2542. Tomonari T, Sato Y, Tanaka H, Tanaka T, Fujino Y, Mitsui Y, Hirao A, Taniguchi T, Okamoto K, Sogabe M, Miyamoto H, Muguruma N, Kagiwada H, Kitazawa M, Fukui K, Horimoto K, Takayama T. PMID: 32655838; PMCID: PMC7335665.
      View in: PubMed   Mentions: 15     Fields:    
    11. Chronic copper exposure directs microglia towards degenerative expression signatures in wild-type and J20 mouse model of Alzheimer's disease. J Trace Elem Med Biol. 2020 Dec; 62:126578. Lim SL, Rodriguez-Ortiz CJ, Hsu HW, Wu J, Zumkehr J, Kilian J, Vidal J, Ayata P, Kitazawa M. PMID: 32599538; PMCID: PMC7655674.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer's Disease-Like Neuropathology in Tg2576 Mice. Mol Neurobiol. 2020 May; 57(5):2447-2460. Lim SL, Tran DN, Kieu Z, Chen C, Villanueva E, Ghiaar S, Gallup V, Zumkehr J, Cribbs DH, Rodriguez-Ortiz CJ, Kitazawa M. PMID: 32146679; PMCID: PMC7187907.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13118. Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. PMID: 32087004; PMCID: PMC7059142.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    14. Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer. Cancer Sci. 2020 Feb; 111(2):658-666. Kitazawa M, Hatta T, Sasaki Y, Fukui K, Ogawa K, Fukuda E, Goshima N, Okita N, Yamada Y, Nakagama H, Natsume T, Horimoto K. PMID: 31823471; PMCID: PMC7004516.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy. Cancer Immunol Res. 2020 03; 8(3):334-344. Kagamu H, Kitano S, Yamaguchi O, Yoshimura K, Horimoto K, Kitazawa M, Fukui K, Shiono A, Mouri A, Nishihara F, Miura Y, Hashimoto K, Murayama Y, Kaira K, Kobayashi K. PMID: 31871122.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    16. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 11 04; 9(1):15936. Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. PMID: 31685865; PMCID: PMC6828807.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21198-21206. Martini AC, Gomez-Arboledas A, Forner S, Rodriguez-Ortiz CJ, McQuade A, Danhash E, Phan J, Javonillo D, Ha JV, Tram M, Trujillo-Estrada L, da Cunha C, Ager RR, Davila JC, Kitazawa M, Blurton-Jones M, Gutierrez A, Baglietto-Vargas D, Medeiros R, LaFerla FM. PMID: 31570577; PMCID: PMC6800331.
      View in: PubMed   Mentions: 10     Fields:    
    18. Copper-Induced Upregulation of MicroRNAs Directs the Suppression of Endothelial LRP1 in Alzheimer's Disease Model. Toxicol Sci. 2019 07 01; 170(1):144-156. Hsu HW, Rodriguez-Ortiz CJ, Lim SL, Zumkehr J, Kilian JG, Vidal J, Kitazawa M. PMID: 30923833; PMCID: PMC6592190.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation. J Mol Biol. 2019 04 19; 431(9):1843-1868. Huat TJ, Camats-Perna J, Newcombe EA, Valmas N, Kitazawa M, Medeiros R. PMID: 30664867; PMCID: PMC6475603.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsPHPublic Health
    20. Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease-like neuropathology. Glia. 2018 12; 66(12):2700-2718. Lim SL, Tran DN, Zumkehr J, Chen C, Ghiaar S, Kieu Z, Villanueva E, Gallup V, Rodriguez-Ortiz CJ, Kitazawa M. PMID: 30277607; PMCID: PMC6645690.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression. Dev Cell. 2018 09 24; 46(6):794-806.e6. Mochizuki Y, Chiba T, Kataoka K, Yamashita S, Sato T, Kato T, Takahashi K, Miyamoto T, Kitazawa M, Hatta T, Natsume T, Takai S, Asahara H. PMID: 30146478; PMCID: PMC6324936.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    22. The emerging risk of exposure to air pollution on cognitive decline and Alzheimer's disease - Evidence from epidemiological and animal studies. Biomed J. 2018 06; 41(3):141-162. Kilian J, Kitazawa M. PMID: 30080655; PMCID: PMC6138768.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsPHPublic Health
    23. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 08; 17(4):e12791. Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. PMID: 29877034; PMCID: PMC6052400.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    24. Environmental and Dietary Exposure to Copper and Its Cellular Mechanisms Linking to Alzheimer's Disease. Toxicol Sci. 2018 06 01; 163(2):338-345. Hsu HW, Bondy SC, Kitazawa M. PMID: 29409005; PMCID: PMC5974786.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansPHPublic Health
    25. Inflammatory Cytokine, IL-1β, Regulates Glial Glutamate Transporter via microRNA-181a in vitro. J Alzheimers Dis. 2018; 63(3):965-975. Zumkehr J, Rodriguez-Ortiz CJ, Medeiros R, Kitazawa M. PMID: 29710703; PMCID: PMC7325598.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    26. Determination of Rate-Limiting Factor for Formation of Beta-Catenin Destruction Complexes Using Absolute Protein Quantification. J Proteome Res. 2017 10 06; 16(10):3576-3584. Kitazawa M, Hatta T, Ogawa K, Fukuda E, Goshima N, Natsume T. PMID: 28810742.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model. Front Syst Neurosci. 2017; 11:48. Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM. PMID: 28713250; PMCID: PMC5491963.
      View in: PubMed   Mentions: 39  
    28. Transfer free graphene growth on SiO2 substrate at 250 °C. Sci Rep. 2017 03 02; 7:43756. Vishwakarma R, Rosmi MS, Takahashi K, Wakamatsu Y, Yaakob Y, Araby MI, Kalita G, Kitazawa M, Tanemura M. PMID: 28251997; PMCID: PMC5333118.
      View in: PubMed   Mentions: 8     Fields:    
    29. Astrocyte transport of glutamate and neuronal activity reciprocally modulate tau pathology in Drosophila. Neuroscience. 2017 04 21; 348:191-200. Kilian JG, Hsu HW, Mata K, Wolf FW, Kitazawa M. PMID: 28215745.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta. Toxicol Sci. 2016 07; 152(1):194-204. Kitazawa M, Hsu HW, Medeiros R. PMID: 27122238; PMCID: PMC4922545.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    31. The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. Am J Pathol. 2016 06; 186(6):1623-34. Rodriguez-Ortiz CJ, Flores JC, Valenzuela JA, Rodriguez GJ, Zumkehr J, Tran DN, Kimonis VE, Kitazawa M. PMID: 27106764; PMCID: PMC4901142.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    32. Infection, systemic inflammation, and Alzheimer's disease. Microbes Infect. 2015 Aug; 17(8):549-56. Lim SL, Rodriguez-Ortiz CJ, Kitazawa M. PMID: 25912134.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    33. Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease. Neurobiol Aging. 2015 Jul; 36(7):2260-2271. Zumkehr J, Rodriguez-Ortiz CJ, Cheng D, Kieu Z, Wai T, Hawkins C, Kilian J, Lim SL, Medeiros R, Kitazawa M. PMID: 25964214.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    34. Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis. 2015; 43(3):893-903. Dunn HC, Ager RR, Baglietto-Vargas D, Cheng D, Kitazawa M, Cribbs DH, Medeiros R. PMID: 25125468; PMCID: PMC4319708.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    35. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014 Apr 16; 82(2):380-97. Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN. PMID: 24742461; PMCID: PMC4161285.
      View in: PubMed   Mentions: 899     Fields:    Translation:AnimalsCells
    36. Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J Alzheimers Dis. 2014; 42(4):1229-38. Rodriguez-Ortiz CJ, Baglietto-Vargas D, Martinez-Coria H, LaFerla FM, Kitazawa M. PMID: 25024332; PMCID: PMC7294908.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    37. α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. Am J Pathol. 2014 Feb; 184(2):520-9. Medeiros R, Castello NA, Cheng D, Kitazawa M, Baglietto-Vargas D, Green KN, Esbenshade TA, Bitner RS, Decker MW, LaFerla FM. PMID: 24269557.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    38. Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition. Neurobiol Dis. 2014 Feb; 62:407-15. Baglietto-Vargas D, Kitazawa M, Le EJ, Estrada-Hernandez T, Rodriguez-Ortiz CJ, Medeiros R, Green KN, LaFerla FM. PMID: 24176788.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    39. Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. Am J Pathol. 2013 Aug; 183(2):504-15. Rodriguez-Ortiz CJ, Hoshino H, Cheng D, Liu-Yescevitz L, Blurton-Jones M, Wolozin B, LaFerla FM, Kitazawa M. PMID: 23747512; PMCID: PMC3730785.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    40. Circadian rhythms, metabolism, and insulin sensitivity: transcriptional networks in animal models. Curr Diab Rep. 2013 Apr; 13(2):223-8. Kitazawa M. PMID: 23266563.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    41. Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May; 182(5):1780-9. Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM. PMID: 23506847; PMCID: PMC3644736.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    42. The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One. 2012; 7(9):e46308. Nalbandian A, Llewellyn KJ, Kitazawa M, Yin HZ, Badadani M, Khanlou N, Edwards R, Nguyen C, Mukherjee J, Mozaffar T, Watts G, Weiss J, Kimonis VE. PMID: 23029473; PMCID: PMC3460820.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    43. Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. Am J Pathol. 2012 Aug; 181(2):616-25. Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM. PMID: 22688056.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    44. Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. Curr Pharm Des. 2012; 18(8):1131-47. Kitazawa M, Medeiros R, Laferla FM. PMID: 22288400; PMCID: PMC4437619.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimals
    45. Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model. J Immunol. 2011 Dec 15; 187(12):6539-49. Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 22095718; PMCID: PMC4072218.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimalsCells
    46. Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol. 2011 Aug; 179(2):980-91. Medeiros R, Kitazawa M, Caccamo A, Baglietto-Vargas D, Estrada-Hernandez T, Cribbs DH, Fisher A, LaFerla FM. PMID: 21704011; PMCID: PMC3157199.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    47. Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator. FEBS Lett. 2011 Jul 21; 585(14):2217-22. Yamajuku D, Shibata Y, Kitazawa M, Katakura T, Urata H, Kojima T, Takayasu S, Nakata O, Hashimoto S. PMID: 21635892.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    48. Angiopoietin-like 2, a circadian gene, improves type 2 diabetes through potentiation of insulin sensitivity in mice adipocytes. Endocrinology. 2011 Jul; 152(7):2558-67. Kitazawa M, Nagano M, Masumoto KH, Shigeyoshi Y, Natsume T, Hashimoto S. PMID: 21586562.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    49. Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol. 2011 Jun; 178(6):2811-22. Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM. PMID: 21531375; PMCID: PMC3124234.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    50. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neurosci Lett. 2011 May 09; 495(1):55-9. Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM. PMID: 21419194; PMCID: PMC3099741.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    51. VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One. 2010 Oct 05; 5(10). Badadani M, Nalbandian A, Watts GD, Vesa J, Kitazawa M, Su H, Tanaja J, Dec E, Wallace DC, Mukherjee J, Caiozzo V, Warman M, Kimonis VE. PMID: 20957154; PMCID: PMC2950155.
      View in: PubMed   Mentions: 67     Fields:    Translation:Animals
    52. Identification of functional clock-controlled elements involved in differential timing of Per1 and Per2 transcription. Nucleic Acids Res. 2010 Dec; 38(22):7964-73. Yamajuku D, Shibata Y, Kitazawa M, Katakura T, Urata H, Kojima T, Nakata O, Hashimoto S. PMID: 20693532; PMCID: PMC3001056.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    53. Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition. PLoS Biol. 2010 Jul 06; 8(7):e1000416. Takeda S, Minakata S, Koike R, Kawahata I, Narita A, Kitazawa M, Ota M, Yamakuni T, Maéda Y, Nitanai Y. PMID: 20625546; PMCID: PMC2897767.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    54. Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One. 2010 Jan 20; 5(1):e8593. Hasegawa T, Mikoda N, Kitazawa M, LaFerla FM. PMID: 20098691; PMCID: PMC2808336.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    55. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2010 Feb; 176(2):870-80. Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM. PMID: 20042680; PMCID: PMC2808092.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    56. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13594-9. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. PMID: 19633196; PMCID: PMC2715325.
      View in: PubMed   Mentions: 347     Fields:    Translation:AnimalsCells
    57. Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J Neurosci. 2009 May 13; 29(19):6132-41. Kitazawa M, Vasilevko V, Cribbs DH, LaFerla FM. PMID: 19439591; PMCID: PMC3049190.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    58. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem. 2009 Mar; 108(6):1550-60. Kitazawa M, Cheng D, Laferla FM. PMID: 19183260; PMCID: PMC4096128.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    59. Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle. Neurobiol Aging. 2010 Dec; 31(12):2080-90. Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW. PMID: 19108934; PMCID: PMC2901770.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    60. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Mol Brain. 2008 Oct 22; 1:12. Kanthasamy AG, Kitazawa M, Yang Y, Anantharam V, Kanthasamy A. PMID: 18945348; PMCID: PMC2584097.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    61. Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase-3beta. Ann Neurol. 2008 Jul; 64(1):15-24. Kitazawa M, Trinh DN, LaFerla FM. PMID: 18318434.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    62. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci. 2007 Oct 31; 27(44):11925-33. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S, LaFerla FM. PMID: 17978032; PMCID: PMC6673368.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    63. Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes. J Pharmacol Exp Ther. 2007 Dec; 323(3):787-93. Kitazawa M, Ohizumi Y, Oike Y, Hishinuma T, Hashimoto S. PMID: 17804676.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    64. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006 Dec 22; 281(51):39413-23. Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM. PMID: 17056594.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    65. Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol. 2006 Jun; 168(6):1986-97. Kitazawa M, Green KN, Caccamo A, LaFerla FM. PMID: 16723713; PMCID: PMC1606633.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    66. Proinsulin C-peptide stimulates a PKC/IkappaB/NF-kappaB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts. J Biochem. 2006 Jun; 139(6):1083-8. Kitazawa M, Shibata Y, Hashimoto S, Ohizumi Y, Yamakuni T. PMID: 16788059.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    67. Antipodal effects of p25 on synaptic plasticity, learning, and memory--too much of a good thing is bad. Neuron. 2005 Dec 08; 48(5):711-2. LaFerla FM, Kitazawa M. PMID: 16337907.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    68. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Sep 28; 25(39):8843-53. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. PMID: 16192374; PMCID: PMC6725603.
      View in: PubMed   Mentions: 344     Fields:    Translation:AnimalsCells
    69. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology. 2005 Aug; 26(4):701-19. Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. PMID: 16112328.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    70. Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model. Neurobiol Aging. 2006 Mar; 27(3):423-32. Sugarman MC, Kitazawa M, Baker M, Caiozzo VJ, Querfurth HW, LaFerla FM. PMID: 15950323.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    71. Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells. Biochem Biophys Res Commun. 2005 May 27; 331(1):181-6. Kitazawa M, Yamakuni T, Song SY, Kato C, Tsuchiya R, Ishida M, Suzuki N, Adachi E, Iwashita S, Ueno S, Yanagihara N, Taoka M, Isobe T, Ohizumi Y. PMID: 15845376.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    72. Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochem Pharmacol. 2005 Jan 01; 69(1):133-46. Kitazawa M, Anantharam V, Yang Y, Hirata Y, Kanthasamy A, Kanthasamy AG. PMID: 15588722.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    73. Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. J Pharmacol Exp Ther. 2005 Apr; 313(1):46-55. Latchoumycandane C, Anantharam V, Kitazawa M, Yang Y, Kanthasamy A, Kanthasamy AG. PMID: 15608081.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    74. Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death. Ann N Y Acad Sci. 2004 Dec; 1035:271-89. Anantharam V, Kitazawa M, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. PMID: 15681813.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    75. Microglia as a potential bridge between the amyloid beta-peptide and tau. Ann N Y Acad Sci. 2004 Dec; 1035:85-103. Kitazawa M, Yamasaki TR, LaFerla FM. PMID: 15681802.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    76. Amyloid beta-peptide: the inside story. Curr Alzheimer Res. 2004 Nov; 1(4):231-9. Tseng BP, Kitazawa M, LaFerla FM. PMID: 15975052.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    77. Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology. 2004 Jun; 25(4):589-98. Kitazawa M, Anantharam V, Kanthasamy A, Kanthasamy AG. PMID: 15183012.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    78. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol Aging. 2003 Dec; 24(8):1063-70. Oddo S, Caccamo A, Kitazawa M, Tseng BP, LaFerla FM. PMID: 14643377.
      View in: PubMed   Mentions: 413     Fields:    Translation:HumansAnimalsCells
    79. Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease. Ann N Y Acad Sci. 2003 Dec; 1010:683-6. Kanthasamy AG, Kitazawa M, Kaul S, Yang Y, Lahiri DK, Anantharam V, Kanthasamy A. PMID: 15033812.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    80. Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxid Redox Signal. 2003 Oct; 5(5):609-20. Kanthasamy AG, Kitazawa M, Kanthasamy A, Anantharam V. PMID: 14580317.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    81. Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration. Eur J Neurosci. 2003 Sep; 18(6):1387-401. Kaul S, Kanthasamy A, Kitazawa M, Anantharam V, Kanthasamy AG. PMID: 14511319.
      View in: PubMed   Mentions: 79  Translation:AnimalsCells
    82. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience. 2003; 119(4):945-64. Kitazawa M, Anantharam V, Kanthasamy AG. PMID: 12831855.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    83. Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. J Pharmacol Exp Ther. 2002 Jul; 302(1):26-35. Kitazawa M, Wagner JR, Kirby ML, Anantharam V, Kanthasamy AG. PMID: 12065696.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    84. Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci. 2002 Mar 01; 22(5):1738-51. Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG. PMID: 11880503; PMCID: PMC6758879.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    85. Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radic Biol Med. 2001 Dec 01; 31(11):1473-85. Kitazawa M, Anantharam V, Kanthasamy AG. PMID: 11728820.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    86. KMD-3213, a uroselective and long-acting alpha(1a)-adrenoceptor antagonist, tested in a novel rat model. J Pharmacol Exp Ther. 1999 Oct; 291(1):81-91. Akiyama K, Hora M, Tatemichi S, Masuda N, Nakamura S, Yamagishi R, Kitazawa M. PMID: 10490890.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    87. Antioxidants modulate acute solar ultraviolet radiation-induced NF-kappa-B activation in a human keratinocyte cell line. Free Radic Biol Med. 1999 Jan; 26(1-2):174-83. Saliou C, Kitazawa M, McLaughlin L, Yang JP, Lodge JK, Tetsuka T, Iwasaki K, Cillard J, Okamoto T, Packer L. PMID: 9890652.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    88. Interactions between vitamin E homologues and ascorbate free radicals in murine skin homogenates irradiated with ultraviolet light. Photochem Photobiol. 1997 Feb; 65(2):355-65. Kitazawa M, Podda M, Thiele J, Traber MG, Iwasaki K, Sakamoto K, Packer L. PMID: 9066312.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    89. Suppression of iron catalyzed free radical generation by iron tyrosinate protein models. Biochem Biophys Res Commun. 1996 Mar 07; 220(1):36-41. Kitazawa M, Iwasaki K. PMID: 8602853.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    90. Effect of aging on spontaneous micronucleus frequencies in peripheral blood of nine mouse strains: the results of the 7th collaborative study organized by CSGMT/JEMS.MMS. Collaborative Study Group for the Micronucleus Test. Environmental Mutagen Society of Japan. Mammalian Mutagenesis Study Group. Mutat Res. 1995 Oct; 338(1-6):51-7. Sato S, Taketomi M, Nakajima M, Kitazawa M, Shimada H, Itoh S, Igarashi M, Higashikuni N, Sutou S, Sasaki YF. PMID: 7565882.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    91. Effects of long-term cilazapril treatment on glucose and lipid metabolism in hypertensive patients with non-insulin-dependent diabetes mellitus. Clin Ther. 1995 Jul-Aug; 17(4):729-34. Uchida K, Kigoshi T, Ishii T, Kitazawa M, Nakano S, Morimoto S. PMID: 8565036.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    92. [Angles among main cranial sutures in Japanese]. Nihon Ika Daigaku Zasshi. 1995 Feb; 62(1):13-8. Akimoto K, Kitazawa M, Tanuma K. PMID: 7721972.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    93. [The cephalic arterial system in dogs, especially on the anastomoses between the intracranial and extracranial circulations]. Kaibogaku Zasshi. 1990 Dec; 65(6):407-19. Kawaguchi T, Tanuma K, Kitazawa M. PMID: 2097880.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    94. Plasma-free eicosapentaenoic acid/arachidonic acid ratio: a possible new coronary risk factor. Clin Cardiol. 1986 Sep; 9(9):413-6. Kondo T, Ogawa K, Satake T, Kitazawa M, Taki K, Sugiyama S, Ozawa T. PMID: 3019597.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    95. [Studies on the synthesis of antiulcer agents. I. Synthesis and antiulcer activity of imide derivatives]. Yakugaku Zasshi. 1984 Jun; 104(6):652-8. Kobayashi M, Kitazawa M, Saito T, Yamamoto R, Harada H. PMID: 6502458.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    96. [Studies on the synthesis of antiulcer agents. III. Synthesis and antiulcer activity of 2,4-oxazolidinedione derivatives]. Yakugaku Zasshi. 1984 Jun; 104(6):680-90. Kobayashi M, Kitazawa M, Saito T. PMID: 6502460.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    97. [Studies on the synthesis of antiulcer agents. II. Synthesis and antiulcer activity of cyclic carbamate derivatives]. Yakugaku Zasshi. 1984 Jun; 104(6):659-79. Kobayashi M, Kitazawa M, Saito T, Yamamoto R, Harada H. PMID: 6502459.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    98. [Synthesis of 2,4-oxazolidinedione and its derivatives]. Yakugaku Zasshi. 1983 Nov; 103(11):1195-9. Kobayashi M, Kitazawa M, Saito T. PMID: 6689559.
      View in: PubMed   Mentions:    Fields:    
    99. [LH and FSH secretion and cell growth on the monolayer culture using adenohypophysis of female rats]. Horumon To Rinsho. 1982 Oct; 30(10):1065-70. Kato K, Kitazawa M, Niibe T, Kojima T, Mori T. PMID: 6819906.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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