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Wood, Marcelo A

TitleFrancisco J. Ayala Chair in Neurobiology and Behavior
InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address2205 McGaugh Hall
Zot 4550
CA 92697
Phone(949) 824-2259
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    Collapse Research 
    Collapse Research Activities and Funding
    Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognition
    NIH/NIA R01AG051807May 15, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Role of HDAC3 in repressing memory formation in the aging brain
    NIH/NIA R21AG050787May 1, 2016 - Jan 31, 2018
    Role: Principal Investigator
    Role of neuron-specific nucleosome remodeling in intellectual disability
    NIH/NIMH R01MH101491Jul 5, 2013 - May 31, 2018
    Role: Principal Investigator
    Coordinate gene expression via nucleosome remodeling and chromosomal looping
    NIH/NIDA R01DA036984Jul 1, 2013 - Mar 31, 2017
    Role: Principal Investigator
    Histone Deacetylases: Regulators of Cocaine Reward and Targets for Therapeutics
    NIH/NIDA R21DA031989Jul 1, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Behavioral and epigenetic mechanisms in extinction of cocaine-induced memories
    NIH/NIDA R01DA025922Sep 15, 2008 - Feb 28, 2019
    Role: Co-Principal Investigator
    Chromatin Remodeling and Memory Storage
    NIH/NIMH R01MH081004Aug 11, 2008 - Mar 31, 2014
    Role: Principal Investigator
    Synaptic and Nuclear Signaling in Memory Formation
    NIH/NIMH R01MH081151Jul 4, 2007 - Apr 30, 2013
    Role: Principal Investigator
    Multiple Memory Phases of Aplysia
    NIH/NIMH R01MH041083Mar 1, 1986 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shu G, Kramár EA, López AJ, Huynh G, Wood M, Kwapis JL. Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b. Learn Mem. 2018 Mar; 25(3):109-114. PMID: 29449454.
      View in: PubMed
    2. López AJ, Jia Y, White AO, Kwapis JL, Espinoza M, Hwang P, Campbell R, Alaghband Y, Chitnis O, Matheos DP, Lynch G, Wood M. Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior. Addict Biol. 2018 Feb 12. PMID: 29430793.
      View in: PubMed
    3. Malvaez M, Greenfield VY, Matheos DP, Angelillis NA, Murphy MD, Kennedy PJ, Wood M, Wassum KM. Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum. Biol Psychiatry. 2018 Feb 08. PMID: 29571524.
      View in: PubMed
    4. Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood M. Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory. Neurobiol Learn Mem. 2017 Nov; 145:94-104. PMID: 28890149.
      View in: PubMed
    5. Liu Y, Sun S, Bredy T, Wood M, Spitale RC, Baldi P. MotifMap-RNA: a genome-wide map of RBP binding sites. Bioinformatics. 2017 Jul 01; 33(13):2029-2031. PMID: 28334276.
      View in: PubMed
    6. Vogel Ciernia A, Kramár EA, Matheos DP, Havekes R, Hemstedt TJ, Magnan CN, Sakata K, Tran A, Azzawi S, Lopez A, Dang R, Wang W, Trieu B, Tong J, Barrett RM, Post RJ, Baldi P, Abel T, Lynch G, Wood M. Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling. Learn Mem. 2017 05; 24(5):199-209. PMID: 28416631.
      View in: PubMed
    7. Hemstedt TJ, Lattal KM, Wood M. Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom. Neurobiol Learn Mem. 2017 Jul; 142(Pt A):55-65. PMID: 28119018.
      View in: PubMed
    8. Kwapis JL, Alaghband Y, López AJ, White AO, Campbell RR, Dang RT, Rhee D, Tran AV, Carl AE, Matheos DP, Wood M. Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala. Neuropsychopharmacology. 2017 May; 42(6):1284-1294. PMID: 27924874.
      View in: PubMed
    9. Kleeman E, Nakauchi S, Su H, Dang R, Wood M, Sumikawa K. Impaired function of a2-containing nicotinic acetylcholine receptors on oriens-lacunosum moleculare cells causes hippocampus-dependent memory impairments. Neurobiol Learn Mem. 2016 Dec; 136:13-20. PMID: 27660076.
      View in: PubMed
    10. Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood M, Jiang Y, Gaisler-Salomon I, Akbarian S. Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nat Commun. 2016 Sep 06; 7:12743. PMID: 27597321; PMCID: PMC5025847.
    11. White AO, Kramár EA, López AJ, Kwapis JL, Doan J, Saldana D, Davatolhagh MF, Alaghband Y, Blurton-Jones M, Matheos DP, Wood M. BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens. Nat Commun. 2016 May 26; 7:11725. PMID: 27226355; PMCID: PMC4894971.
    12. López AJ, Kramár E, Matheos DP, White AO, Kwapis J, Vogel-Ciernia A, Sakata K, Espinoza M, Wood M. Promoter-Specific Effects of DREADD Modulation on Hippocampal Synaptic Plasticity and Memory Formation. J Neurosci. 2016 Mar 23; 36(12):3588-99. PMID: 27013687; PMCID: PMC4804014.
    13. Alaghband Y, Bredy TW, Wood M. The role of active DNA demethylation and Tet enzyme function in memory formation and cocaine action. Neurosci Lett. 2016 06 20; 625:40-6. PMID: 26806038.
      View in: PubMed
    14. Bieszczad KM, Bechay K, Rusche JR, Jacques V, Kudugunti S, Miao W, Weinberger NM, McGaugh JL, Wood M. Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation. J Neurosci. 2015 Sep 23; 35(38):13124-32. PMID: 26400942; PMCID: PMC4579377.
    15. Peixoto L, Risso D, Poplawski SG, Wimmer ME, Speed TP, Wood M, Abel T. How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets. Nucleic Acids Res. 2015 Sep 18; 43(16):7664-74. PMID: 26202970; PMCID: PMC4652761.
    16. López AJ, Wood M. Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders. Front Behav Neurosci. 2015; 9:100. PMID: 25954173; PMCID: PMC4407585.
    17. Nakauchi S, Malvaez M, Su H, Kleeman E, Dang R, Wood M, Sumikawa K. Early postnatal nicotine exposure causes hippocampus-dependent memory impairments in adolescent mice: Association with altered nicotinic cholinergic modulation of LTP, but not impaired LTP. Neurobiol Learn Mem. 2015 Feb; 118:178-88. PMID: 25545599; PMCID: PMC4331249.
    18. Bharadwaj R, Peter CJ, Jiang Y, Roussos P, Vogel-Ciernia A, Shen EY, Mitchell AC, Mao W, Whittle C, Dincer A, Jakovcevski M, Pothula V, Rasmussen TP, Giakoumaki SG, Bitsios P, Sherif A, Gardner PD, Ernst P, Ghose S, Sklar P, Haroutunian V, Tamminga C, Myers RH, Futai K, Wood M, Akbarian S. Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition. Neuron. 2014 Dec 03; 84(5):997-1008. PMID: 25467983; PMCID: PMC4258154.
    19. Vogel-Ciernia A, Wood M. Examining object location and object recognition memory in mice. Curr Protoc Neurosci. 2014 Oct 08; 69:8.31.1-17. PMID: 25297693; PMCID: PMC4219523.
    20. Kwapis JL, Wood M. Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder. Trends Neurosci. 2014 Dec; 37(12):706-20. PMID: 25220045; PMCID: PMC4258434.
    21. Matheos DP, Wood M. Unlocking the constraints on memory formation. Nat Neurosci. 2014 Jul; 17(7):895-6. PMID: 24964157.
      View in: PubMed
    22. White AO, Wood M. Does stress remove the HDAC brakes for the formation and persistence of long-term memory? Neurobiol Learn Mem. 2014 Jul; 112:61-7. PMID: 24149059; PMCID: PMC3992200.
    23. Vogel-Ciernia A, Wood M. Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders. Neuropharmacology. 2014 May; 80:18-27. PMID: 24140580; PMCID: PMC3984593.
    24. Cope JL, Regev L, Chen Y, Korosi A, Rice CJ, Ji S, Rogge GA, Wood M, Baram TZ. Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress. 2014 Jan; 17(1):39-50. PMID: 23768074; PMCID: PMC3869921.
    25. Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ, Wood M, Cotman CW. Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology. 2013 Sep; 38(10):2027-34. PMID: 23615664; PMCID: PMC3746687.
    26. Rogge GA, Singh H, Dang R, Wood M. HDAC3 is a negative regulator of cocaine-context-associated memory formation. J Neurosci. 2013 Apr 10; 33(15):6623-32. PMID: 23575859; PMCID: PMC3670682.
    27. Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood M. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013 May; 16(5):552-61. PMID: 23525042; PMCID: PMC3777648.
    28. Raybuck JD, McCleery EJ, Cunningham CL, Wood M, Lattal KM. The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference. Pharmacol Biochem Behav. 2013 May; 106:109-16. PMID: 23454534; PMCID: PMC3691316.
    29. Haettig J, Sun Y, Wood M, Xu X. Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learn Mem. 2013 Feb 15; 20(3):139-46. PMID: 23418393; PMCID: PMC3578275.
    30. Lattal KM, Wood M. Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero. Nat Neurosci. 2013 Feb; 16(2):124-9. PMID: 23354385; PMCID: PMC3740093.
    31. Malvaez M, McQuown SC, Rogge GA, Astarabadi M, Jacques V, Carreiro S, Rusche JR, Wood M. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):2647-52. PMID: 23297220; PMCID: PMC3574934.
    32. McNulty SE, Barrett RM, Vogel-Ciernia A, Malvaez M, Hernandez N, Davatolhagh MF, Matheos DP, Schiffman A, Wood M. Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory. Learn Mem. 2012 Nov 16; 19(12):588-92. PMID: 23161447; PMCID: PMC3506974.
    33. Babayan AH, Kramár EA, Barrett RM, Jafari M, Häettig J, Chen LY, Rex CS, Lauterborn JC, Wood M, Gall CM, Lynch G. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012 Sep 12; 32(37):12854-61. PMID: 22973009; PMCID: PMC3752079.
    34. Rogge GA, Wood M. The role of histone acetylation in cocaine-induced neural plasticity and behavior. Neuropsychopharmacology. 2013 Jan; 38(1):94-110. PMID: 22910457; PMCID: PMC3521972.
    35. Vogel-Ciernia A, Wood M. Molecular brake pad hypothesis: pulling off the brakes for emotional memory. Rev Neurosci. 2012; 23(5-6):607-26. PMID: 23096102; PMCID: PMC4605538.
    36. Malvaez M, Mhillaj E, Matheos DP, Palmery M, Wood M. CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors. J Neurosci. 2011 Nov 23; 31(47):16941-8. PMID: 22114264; PMCID: PMC3235434.
    37. Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood M, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012 Feb 15; 3(2):120-128. PMID: 22754608.
      View in: PubMed
    38. Wood M. Introduction to the special issue of Neurobiology of Learning and Memory on epigenetics and memory. Neurobiol Learn Mem. 2011 Jul; 96(1):1. PMID: 21652003.
      View in: PubMed
    39. Lester BM, Tronick E, Nestler E, Abel T, Kosofsky B, Kuzawa CW, Marsit CJ, Maze I, Meaney MJ, Monteggia LM, Reul JM, Skuse DH, Sweatt JD, Wood M. Behavioral epigenetics. Ann N Y Acad Sci. 2011 May; 1226:14-33. PMID: 21615751; PMCID: PMC3783959.
    40. Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood M, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. J Neurosci. 2011 Apr 27; 31(17):6392-7. PMID: 21525279; PMCID: PMC3107562.
    41. Barrett RM, Malvaez M, Kramar E, Matheos DP, Arrizon A, Cabrera SM, Lynch G, Greene RW, Wood M. Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology. 2011 Jul; 36(8):1545-56. PMID: 21508930; PMCID: PMC3138668.
    42. McQuown SC, Wood M. HDAC3 and the molecular brake pad hypothesis. Neurobiol Learn Mem. 2011 Jul; 96(1):27-34. PMID: 21521655; PMCID: PMC3111848.
    43. Reolon GK, Maurmann N, Werenicz A, Garcia VA, Schröder N, Wood M, Roesler R. Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. Behav Brain Res. 2011 Aug 01; 221(1):329-32. PMID: 21421011; PMCID: PMC3093300.
    44. McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA, Wood M. HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci. 2011 Jan 12; 31(2):764-74. PMID: 21228185; PMCID: PMC3160172.
    45. Haettig J, Stefanko DP, Multani ML, Figueroa DX, McQuown SC, Wood M. HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Learn Mem. 2011 Feb; 18(2):71-9. PMID: 21224411; PMCID: PMC3032579.
    46. Roozendaal B, Hernandez A, Cabrera SM, Hagewoud R, Malvaez M, Stefanko DP, Haettig J, Wood M. Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification. J Neurosci. 2010 Apr 07; 30(14):5037-46. PMID: 20371824; PMCID: PMC2861482.
    47. McQuown SC, Wood M. Epigenetic regulation in substance use disorders. Curr Psychiatry Rep. 2010 Apr; 12(2):145-53. PMID: 20425300; PMCID: PMC2847696.
    48. Malvaez M, Sanchis-Segura C, Vo D, Lattal KM, Wood M. Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference. Biol Psychiatry. 2010 Jan 01; 67(1):36-43. PMID: 19765687; PMCID: PMC2795056.
    49. Malvaez M, Barrett RM, Wood M, Sanchis-Segura C. Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. Mamm Genome. 2009 Sep-Oct; 20(9-10):612-23. PMID: 19789849; PMCID: PMC3157916.
    50. Stefanko DP, Barrett RM, Ly AR, Reolon GK, Wood M. Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9447-52. PMID: 19470462; PMCID: PMC2695069.
    51. Pham J, Cabrera SM, Sanchis-Segura C, Wood M. Automated scoring of fear-related behavior using EthoVision software. J Neurosci Methods. 2009 Apr 15; 178(2):323-6. PMID: 19150629; PMCID: PMC2649987.
    52. Jiang Y, Langley B, Lubin FD, Renthal W, Wood M, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC. Epigenetics in the nervous system. J Neurosci. 2008 Nov 12; 28(46):11753-9. PMID: 19005036; PMCID: PMC3844836.
    53. Barrett RM, Wood M. Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem. 2008 Jul; 15(7):460-7. PMID: 18583646; PMCID: PMC3960025.
    54. Lattal KM, Barrett RM, Wood M. Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction. Behav Neurosci. 2007 Oct; 121(5):1125-31. PMID: 17907845.
      View in: PubMed
    55. Oliveira AM, Wood M, McDonough CB, Abel T. Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem. 2007 Sep; 14(9):564-72. PMID: 17761541; PMCID: PMC1994075.
    56. Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood M. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci. 2007 Jun 06; 27(23):6128-40. PMID: 17553985; PMCID: PMC2925045.
    57. Wood M, Attner MA, Oliveira AM, Brindle PK, Abel T. A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem. 2006 Sep-Oct; 13(5):609-17. PMID: 16980541; PMCID: PMC1783615.
    58. Oliveira AM, Abel T, Brindle PK, Wood M. Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behav Neurosci. 2006 Jun; 120(3):724-9. PMID: 16768624.
      View in: PubMed
    59. Wood M, Hawk JD, Abel T. Combinatorial chromatin modifications and memory storage: a code for memory? Learn Mem. 2006 May-Jun; 13(3):241-4. PMID: 16741277; PMCID: PMC2909467.
    60. Keeley MB, Wood M, Isiegas C, Stein J, Hellman K, Hannenhalli S, Abel T. Differential transcriptional response to nonassociative and associative components of classical fear conditioning in the amygdala and hippocampus. Learn Mem. 2006 Mar-Apr; 13(2):135-42. PMID: 16547164; PMCID: PMC1409829.
    61. Zhang B, Veasey SC, Wood M, Leng LZ, Kaminski C, Leight S, Abel T, Lee VM, Trojanowski JQ. Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol. 2005 Nov; 167(5):1361-9. PMID: 16251420; PMCID: PMC1603771.
    62. Wood M, Kaplan MP, Park A, Blanchard EJ, Oliveira AM, Lombardi TL, Abel T. Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learn Mem. 2005 Mar-Apr; 12(2):111-9. PMID: 15805310; PMCID: PMC1074328.
    63. Wood M, Kaplan MP, Brensinger CM, Guo W, Abel T. Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. Hippocampus. 2005; 15(5):610-21. PMID: 15884048.
      View in: PubMed
    64. Dugan KA, Wood M, Cole MD. TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis. Oncogene. 2002 Aug 29; 21(38):5835-43. PMID: 12185582.
      View in: PubMed
    65. Park J, Wood M, Cole MD. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol. 2002 Mar; 22(5):1307-16. PMID: 11839798; PMCID: PMC134713.