Loading...

Ulrike Luderer

Title(s)Professor, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8081
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Interactions of glutathione, reactive oxygen species, and lipids on oocyte mitochondrial function
    NIH/NICHD R21HD097541Sep 1, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Developmental Gene-Environment Interactions and Premature Ovarian Failure
    NIH/NIEHS R01ES020454Jan 10, 2012 - Oct 31, 2016
    Role: Principal Investigator
    Modulation of PAH ovarian toxicity by biotransformation enzyme polymorphisms
    NIH/NIEHS R21ES016846Aug 15, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Oxidative stress drives ovarian aging: modification by genetics and environment
    NIH/NIA R21AG032087Sep 30, 2008 - Aug 31, 2011
    Role: Principal Investigator
    GSH: Protecting Ovarian Follicles from Oxidant Injury
    NIH/NIEHS K08ES010963Mar 14, 2002 - Nov 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†. Biol Reprod. 2020 04 24; 102(5):1065-1079. Lim J, Ali S, Liao LS, Nguyen ES, Ortiz L, Reshel S, Luderer U. PMID: 31950131.
      View in: PubMed   Mentions: 1     Fields:    
    2. Author Correction: Reproductive hazards of space travel in women and men. Nat Rev Endocrinol. 2019 Dec; 15(12):744. Mishra B, Luderer U. PMID: 31666672.
      View in: PubMed   Mentions:    Fields:    
    3. Reproductive hazards of space travel in women and men. Nat Rev Endocrinol. 2019 12; 15(12):713-730. Mishra B, Luderer U. PMID: 31611649.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    4. Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment. Environ Health Perspect. 2019 07; 127(7):75001. Luderer U, Eskenazi B, Hauser R, Korach KS, McHale CM, Moran F, Rieswijk L, Solomon G, Udagawa O, Zhang L, Zlatnik M, Zeise L, Smith MT. PMID: 31322437.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses That Deplete Ovarian Follicles in Mice. Environ Mol Mutagen. 2019 06; 60(5):410-420. Luderer U, Meier MJ, Lawson GW, Beal MA, Yauk CL, Marchetti F. PMID: 30353947.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    6. Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis. Toxicol Appl Pharmacol. 2018 08 01; 352:38-45. Lim J, Luderer U. PMID: 29800640.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors. Radiat Res. 2018 08; 190(2):142-150. Mishra B, Lawson GW, Ripperdan R, Ortiz L, Luderer U. PMID: 29781764.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Transitions in pregnancy planning in women recruited for a large prospective cohort study. Hum Reprod. 2017 06 01; 32(6):1325-1333. Luderer U, Li T, Fine JP, Hamman RF, Stanford JB, Baker D. PMID: 28398523.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Very low doses of heavy oxygen ion radiation induce premature ovarian failure. Reproduction. 2017 Aug; 154(2):123-133. Mishra B, Ripperdan R, Ortiz L, Luderer U. PMID: 28528322.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    10. Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. Reprod Toxicol. 2017 04; 69:187-195. Luderer U, Myers MB, Banda M, McKim KL, Ortiz L, Parsons BL. PMID: 28279692.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    11. Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women. Environ Int. 2017 Mar; 100:110-120. Luderer U, Christensen F, Johnson WO, She J, Ip HS, Zhou J, Alvaran J, Krieg EF, Kesner JS. PMID: 28065424.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    12. Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary. Biol Reprod. 2016 12; 95(6):129. Cinco R, Digman MA, Gratton E, Luderer U. PMID: 27683265.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Charged iron particles, components of space radiation, destroy ovarian follicles. Hum Reprod. 2016 08; 31(8):1816-26. Mishra B, Ortiz L, Luderer U. PMID: 27251203.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. The Mouse Fetal Ovary Has Greater Sensitivity Than the Fetal Testis to Benzo[a]pyrene-Induced Germ Cell Death. Toxicol Sci. 2016 08; 152(2):372-81. Lim J, Kong W, Lu M, Luderer U. PMID: 27208085.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. Reprod Toxicol. 2015 Dec; 58:24-32. Lim J, Ortiz L, Nakamura BN, Hoang YD, Banuelos J, Flores VN, Chan JY, Luderer U. PMID: 26247513.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sci Space Res (Amst). 2015 Jul; 6:92-103. Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM. PMID: 26256633.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsPHPublic Health
    17. Glutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian Failure. Endocrinology. 2015 Sep; 156(9):3329-43. Lim J, Nakamura BN, Mohar I, Kavanagh TJ, Luderer U. PMID: 26083875.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    18. Ovarian toxicity from reactive oxygen species. Vitam Horm. 2014; 94:99-127. Luderer U. PMID: 24388188.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsPHPublic Health
    19. Reprint of "In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective". Toxicol Lett. 2014 Oct 15; 230(2):314-21. Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U. PMID: 24291350.
      View in: PubMed   Mentions: 4     Fields:    
    20. In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective. Toxicol Lett. 2013 Nov 25; 223(2):260-7. Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U. PMID: 24107266.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women. Environ Res. 2013 Feb; 121:84-94. Luderer U, Kesner JS, Fuller JM, Krieg EF, Meadows JW, Tramma SL, Yang H, Baker D. PMID: 23194642.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    22. Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis. Cancer Res. 2013 Jan 15; 73(2):908-17. Lim J, Lawson GW, Nakamura BN, Ortiz L, Hur JA, Kavanagh TJ, Luderer U. PMID: 23135907.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    23. Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biol Reprod. 2012 Feb; 86(2):27. Devine PJ, Perreault SD, Luderer U. PMID: 22034525.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    24. Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice. Toxicol Sci. 2012 Mar; 126(1):227-41. Nakamura BN, Mohar I, Lawson GW, Cortés MM, Hoang YD, Ortiz L, Patel R, Rau BA, McConnachie LA, Kavanagh TJ, Luderer U. PMID: 22253057.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Reproductive and developmental hazard management guidance: ACOEM Task Force on Reproductive Toxicology. J Occup Environ Med. 2011 Aug; 53(8):941-9. Luderer U, Hieb M, Diaz J, Baker B. PMID: 21775895.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    26. Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice. Endocrinology. 2011 Jul; 152(7):2806-15. Nakamura BN, Fielder TJ, Hoang YD, Lim J, McConnachie LA, Kavanagh TJ, Luderer U. PMID: 21558310.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary. Biol Reprod. 2011 Apr; 84(4):775-82. Lim J, Luderer U. PMID: 21148108.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    28. Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. Free Radic Biol Med. 2010 Nov 15; 49(9):1368-79. Nakamura BN, Lawson G, Chan JY, Banuelos J, Cortés MM, Hoang YD, Ortiz L, Rau BA, Luderer U. PMID: 20692336.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    29. Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells. Biol Reprod. 2009 Oct; 81(4):636-46. Hoang YD, Nakamura BN, Luderer U. PMID: 19516019.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    30. Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death. Mutagenesis. 2009 May; 24(3):211-24. Cortes-Wanstreet MM, Giedzinski E, Limoli CL, Luderer U. PMID: 19153097.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem. 2009 Feb 06; 284(6):3488-95. Pedram A, Razandi M, Kim JK, O'Mahony F, Lee EY, Luderer U, Levin ER. PMID: 19054762.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    32. Induction of apoptosis by 9,10-dimethyl-1,2-benzanthracene in cultured preovulatory rat follicles is preceded by a rise in reactive oxygen species and is prevented by glutathione. Biol Reprod. 2007 Sep; 77(3):442-51. Tsai-Turton M, Nakamura BN, Luderer U. PMID: 17554082.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    33. Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. Toxicol Sci. 2007 Jul; 98(1):216-30. Tsai-Turton M, Luong BT, Tan Y, Luderer U. PMID: 17434952.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    34. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene. Birth Defects Res B Dev Reprod Toxicol. 2006 Apr; 77(2):110-93. Luderer U, Collins TF, Daston GP, Fischer LJ, Gray RH, Mirer FE, Olshan AF, Setzer RW, Treinen KA, Vermeulen R. PMID: 16345075.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    35. Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles. Endocrinology. 2006 Mar; 147(3):1224-36. Tsai-Turton M, Luderer U. PMID: 16339198.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    36. Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine. Reprod Toxicol. 2006 Feb; 21(2):186-96. Hoang YD, Avakian AP, Luderer U. PMID: 16183247.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific. Am J Physiol Endocrinol Metab. 2005 Sep; 289(3):E391-402. Tsai-Turton M, Luderer U. PMID: 15811874.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    38. Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men. Am J Ind Med. 2004 Dec; 46(6):614-26. Luderer U, Bushley A, Stover BD, Bremner WJ, Faustman EM, Takaro TK, Checkoway H, Brodkin CA. PMID: 15551391.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    39. Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats. Vet Hum Toxicol. 2004 Jun; 46(3):113-8. Lawson G, Luderer U. PMID: 15171484.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis. Free Radic Biol Med. 2004 Jun 01; 36(11):1366-77. Lopez SG, Luderer U. PMID: 15135172.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    41. Temporal association between serum prolactin concentration and exposure to styrene. Occup Environ Med. 2004 Apr; 61(4):325-33. Luderer U, Tornero-Velez R, Shay T, Rappaport S, Heyer N, Echeverria D. PMID: 15031390.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    42. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane. Reprod Toxicol. 2004 Mar-Apr; 18(2):189-217. Boekelheide K, Darney SP, Daston GP, David RM, Luderer U, Olshan AF, Sanderson WT, Willhite CC, Woskie S. PMID: 15019719.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    43. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Mol Reprod Dev. 2003 Jul; 65(3):254-61. Luderer U, Diaz D, Faustman EM, Kavanagh TJ. PMID: 12784246.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod Toxicol. 2001 Sep-Oct; 15(5):495-504. Luderer U, Kavanagh TJ, White CC, Faustman EM. PMID: 11780957.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    45. Reproductive endocrine effects of acute exposure to toluene in men and women. Occup Environ Med. 1999 Oct; 56(10):657-66. Luderer U, Morgan MS, Brodkin CA, Kalman DA, Faustman EM. PMID: 10658543.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    46. Calls on reproductive and developmental toxicants to a regional poison center. Vet Hum Toxicol. 1999 Feb; 41(1):42-6. Luderer U, Burgess JL, Polifka JE, Robertson WO. PMID: 9949487.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Acute changes in pulsatile LH and FSH secretion after ovariectomy in rats: treatment with oestradiol for 24 h suppresses LH, but not FSH, for at least 48 h. J Reprod Fertil. 1994 Mar; 100(2):613-21. Luderer U, Schwartz NB. PMID: 8021884.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    48. Differential gonadotropin responses to N-methyl-D,L-aspartate in metestrous, proestrous, and ovariectomized rats. Biol Reprod. 1993 Apr; 48(4):857-66. Luderer U, Strobl FJ, Levine JE, Schwartz NB. PMID: 8485252.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    49. Differential gonadotropin responses to N-methyl-D,L-aspartate in intact and castrated male rats. Biol Reprod. 1993 Apr; 48(4):867-73. Strobl FJ, Luderer U, Besecke L, Wolfe A, Schwartz NB, Levine JE. PMID: 8485253.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    50. Sex differences in acute luteinizing hormone responses to gonadectomy remain after progesterone antagonist and dopamine agonist treatment. Biol Reprod. 1991 Dec; 45(6):918-26. Luderer U, Schwartz NB. PMID: 1687201.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    Ulrike's Networks
    Concepts (299)
    Derived automatically from this person's publications.
    _
    Co-Authors (10)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _