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Luderer, Ulrike

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8081
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    Collapse Research 
    Collapse Research Activities and Funding
    Developmental Gene-Environment Interactions and Premature Ovarian Failure
    NIH/NIEHS R01ES020454Jan 10, 2012 - Jul 31, 2022
    Role: Principal Investigator
    Modulation of PAH ovarian toxicity by biotransformation enzyme polymorphisms
    NIH/NIEHS R21ES016846Aug 15, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Oxidative stress drives ovarian aging: modification by genetics and environment
    NIH/NIA R21AG032087Sep 30, 2008 - Aug 31, 2011
    Role: Principal Investigator
    GSH: Protecting Ovarian Follicles from Oxidant Injury
    NIH/NIEHS K08ES010963Mar 14, 2002 - Nov 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lim J, Luderer U. Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis. Toxicol Appl Pharmacol. 2018 May 22; 352:38-45. PMID: 29800640.
      View in: PubMed
    2. Mishra B, Lawson GW, Ripperdan R, Ortiz L, Luderer U. Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors. Radiat Res. 2018 May 21. PMID: 29781764.
      View in: PubMed
    3. Luderer U, Li T, Fine JP, Hamman RF, Stanford JB, Baker D. Transitions in pregnancy planning in women recruited for a large prospective cohort study. Hum Reprod. 2017 06 01; 32(6):1325-1333. PMID: 28398523.
      View in: PubMed
    4. Mishra B, Ripperdan R, Ortiz L, Luderer U. Very low doses of heavy oxygen ion radiation induce premature ovarian failure. Reproduction. 2017 08; 154(2):123-133. PMID: 28528322.
      View in: PubMed
    5. Luderer U, Myers MB, Banda M, McKim KL, Ortiz L, Parsons BL. Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. Reprod Toxicol. 2017 04; 69:187-195. PMID: 28279692.
      View in: PubMed
    6. Luderer U, Christensen F, Johnson WO, She J, Ip HS, Zhou J, Alvaran J, Krieg EF, Kesner JS. Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women. Environ Int. 2017 03; 100:110-120. PMID: 28065424.
      View in: PubMed
    7. Cinco R, Digman MA, Gratton E, Luderer U. Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary. Biol Reprod. 2016 12; 95(6):129. PMID: 27683265.
      View in: PubMed
    8. Mishra B, Ortiz L, Luderer U. Charged iron particles, components of space radiation, destroy ovarian follicles. Hum Reprod. 2016 08; 31(8):1816-26. PMID: 27251203.
      View in: PubMed
    9. Lim J, Kong W, Lu M, Luderer U. The Mouse Fetal Ovary Has Greater Sensitivity Than the Fetal Testis to Benzo[a]pyrene-Induced Germ Cell Death. Toxicol Sci. 2016 08; 152(2):372-81. PMID: 27208085.
      View in: PubMed
    10. Lim J, Ortiz L, Nakamura BN, Hoang YD, Banuelos J, Flores VN, Chan JY, Luderer U. Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. Reprod Toxicol. 2015 Dec; 58:24-32. PMID: 26247513; PMCID: PMC4690751 [Available on 12/01/16].
    11. Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sci Space Res (Amst). 2015 Jul; 6:92-103. PMID: 26256633.
      View in: PubMed
    12. Lim J, Nakamura BN, Mohar I, Kavanagh TJ, Luderer U. Glutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian Failure. Endocrinology. 2015 Sep; 156(9):3329-43. PMID: 26083875; PMCID: PMC4541624.
    13. Luderer U. Ovarian toxicity from reactive oxygen species. Vitam Horm. 2014; 94:99-127. PMID: 24388188.
      View in: PubMed
    14. Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U. Reprint of "In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective". Toxicol Lett. 2014 Oct 15; 230(2):314-21. PMID: 24291350.
      View in: PubMed
    15. Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U. In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective. Toxicol Lett. 2013 Nov 25; 223(2):260-7. PMID: 24107266; PMCID: PMC3856224.
    16. Luderer U, Kesner JS, Fuller JM, Krieg EF, Meadows JW, Tramma SL, Yang H, Baker D. Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women. Environ Res. 2013 Feb; 121:84-94. PMID: 23194642.
      View in: PubMed
    17. Lim J, Lawson GW, Nakamura BN, Ortiz L, Hur JA, Kavanagh TJ, Luderer U. Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis. Cancer Res. 2013 Jan 15; 73(2):908-17. PMID: 23135907; PMCID: PMC3548973.
    18. Devine PJ, Perreault SD, Luderer U. Roles of reactive oxygen species and antioxidants in ovarian toxicity. Biol Reprod. 2012 Feb; 86(2):27. PMID: 22034525; PMCID: PMC3290661.
    19. Nakamura BN, Mohar I, Lawson GW, Cortés MM, Hoang YD, Ortiz L, Patel R, Rau BA, McConnachie LA, Kavanagh TJ, Luderer U. Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice. Toxicol Sci. 2012 Mar; 126(1):227-41. PMID: 22253057; PMCID: PMC3289497.
    20. Luderer U, Hieb M, Diaz J, Baker B. Reproductive and developmental hazard management guidance: ACOEM Task Force on Reproductive Toxicology. J Occup Environ Med. 2011 Aug; 53(8):941-9. PMID: 21775895.
      View in: PubMed
    21. Nakamura BN, Fielder TJ, Hoang YD, Lim J, McConnachie LA, Kavanagh TJ, Luderer U. Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice. Endocrinology. 2011 Jul; 152(7):2806-15. PMID: 21558310; PMCID: PMC3115613.
    22. Lim J, Luderer U. Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary. Biol Reprod. 2011 Apr; 84(4):775-82. PMID: 21148108; PMCID: PMC3062040.
    23. Nakamura BN, Lawson G, Chan JY, Banuelos J, Cortés MM, Hoang YD, Ortiz L, Rau BA, Luderer U. Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner. Free Radic Biol Med. 2010 Nov 15; 49(9):1368-79. PMID: 20692336; PMCID: PMC2948056.
    24. Hoang YD, Nakamura BN, Luderer U. Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells. Biol Reprod. 2009 Oct; 81(4):636-46. PMID: 19516019; PMCID: PMC2754881.
    25. Cortes-Wanstreet MM, Giedzinski E, Limoli CL, Luderer U. Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death. Mutagenesis. 2009 May; 24(3):211-24. PMID: 19153097; PMCID: PMC2674984.
    26. Pedram A, Razandi M, Kim JK, O'Mahony F, Lee EY, Luderer U, Levin ER. Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem. 2009 Feb 06; 284(6):3488-95. PMID: 19054762; PMCID: PMC2635032.
    27. Tsai-Turton M, Nakamura BN, Luderer U. Induction of apoptosis by 9,10-dimethyl-1,2-benzanthracene in cultured preovulatory rat follicles is preceded by a rise in reactive oxygen species and is prevented by glutathione. Biol Reprod. 2007 Sep; 77(3):442-51. PMID: 17554082.
      View in: PubMed
    28. Tsai-Turton M, Luong BT, Tan Y, Luderer U. Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. Toxicol Sci. 2007 Jul; 98(1):216-30. PMID: 17434952.
      View in: PubMed
    29. Luderer U, Collins TF, Daston GP, Fischer LJ, Gray RH, Mirer FE, Olshan AF, Setzer RW, Treinen KA, Vermeulen R. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene. Birth Defects Res B Dev Reprod Toxicol. 2006 Apr; 77(2):110-93. PMID: 16345075.
      View in: PubMed
    30. Tsai-Turton M, Luderer U. Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles. Endocrinology. 2006 Mar; 147(3):1224-36. PMID: 16339198.
      View in: PubMed
    31. Hoang YD, Avakian AP, Luderer U. Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine. Reprod Toxicol. 2006 Feb; 21(2):186-96. PMID: 16183247.
      View in: PubMed
    32. Tsai-Turton M, Luderer U. Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific. Am J Physiol Endocrinol Metab. 2005 Sep; 289(3):E391-402. PMID: 15811874.
      View in: PubMed
    33. Luderer U, Bushley A, Stover BD, Bremner WJ, Faustman EM, Takaro TK, Checkoway H, Brodkin CA. Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men. Am J Ind Med. 2004 Dec; 46(6):614-26. PMID: 15551391.
      View in: PubMed
    34. Lawson G, Luderer U. Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats. Vet Hum Toxicol. 2004 Jun; 46(3):113-8. PMID: 15171484.
      View in: PubMed
    35. Lopez SG, Luderer U. Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis. Free Radic Biol Med. 2004 Jun 01; 36(11):1366-77. PMID: 15135172.
      View in: PubMed
    36. Luderer U, Tornero-Velez R, Shay T, Rappaport S, Heyer N, Echeverria D. Temporal association between serum prolactin concentration and exposure to styrene. Occup Environ Med. 2004 Apr; 61(4):325-33. PMID: 15031390; PMCID: PMC1740755.
    37. Boekelheide K, Darney SP, Daston GP, David RM, Luderer U, Olshan AF, Sanderson WT, Willhite CC, Woskie S. NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane. Reprod Toxicol. 2004 Mar-Apr; 18(2):189-217. PMID: 15019719.
      View in: PubMed
    38. Luderer U, Diaz D, Faustman EM, Kavanagh TJ. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Mol Reprod Dev. 2003 Jul; 65(3):254-61. PMID: 12784246.
      View in: PubMed
    39. Luderer U, Kavanagh TJ, White CC, Faustman EM. Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod Toxicol. 2001 Sep-Oct; 15(5):495-504. PMID: 11780957.
      View in: PubMed
    40. Luderer U, Morgan MS, Brodkin CA, Kalman DA, Faustman EM. Reproductive endocrine effects of acute exposure to toluene in men and women. Occup Environ Med. 1999 Oct; 56(10):657-66. PMID: 10658543; PMCID: PMC1757663.
    41. Luderer U, Burgess JL, Polifka JE, Robertson WO. Calls on reproductive and developmental toxicants to a regional poison center. Vet Hum Toxicol. 1999 Feb; 41(1):42-6. PMID: 9949487.
      View in: PubMed
    42. Luderer U, Strobl FJ, Levine JE, Schwartz NB. Differential gonadotropin responses to N-methyl-D,L-aspartate in metestrous, proestrous, and ovariectomized rats. Biol Reprod. 1993 Apr; 48(4):857-66. PMID: 8485252.
      View in: PubMed
    43. Strobl FJ, Luderer U, Besecke L, Wolfe A, Schwartz NB, Levine JE. Differential gonadotropin responses to N-methyl-D,L-aspartate in intact and castrated male rats. Biol Reprod. 1993 Apr; 48(4):867-73. PMID: 8485253.
      View in: PubMed
    44. Luderer U, Schwartz NB. Sex differences in acute luteinizing hormone responses to gonadectomy remain after progesterone antagonist and dopamine agonist treatment. Biol Reprod. 1991 Dec; 45(6):918-26. PMID: 1687201.
      View in: PubMed