James E Hall

Title(s)Professor Emeritus, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5835
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    Collapse Research 
    Collapse Research Activities and Funding
    NIH R01GM057998Aug 1, 1998 - Mar 31, 2004
    Role: Principal Investigator
    NIH R41AI040518Sep 30, 1996 - Sep 29, 1997
    Role: Principal Investigator
    NIH R13EY009132May 1, 1991 - Apr 30, 1992
    Role: Principal Investigator
    Structure and Function of Lens Channels
    NIH R01EY005661Mar 1, 1985 - Aug 31, 2019
    Role: Principal Investigator
    NIH R01GM030657May 1, 1978 - Aug 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders. Sci Adv. 2024 Feb 09; 10(6):eadj5661. Lawrence ES, Gu W, Bohlender RJ, Anza-Ramirez C, Cole AM, Yu JJ, Hu H, Heinrich EC, O'Brien KA, Vasquez CA, Cowan QT, Bruck PT, Mercader K, Alotaibi M, Long T, Hall JE, Moya EA, Bauk MA, Reeves JJ, Kong MC, Salem RM, Vizcardo-Galindo G, Macarlupu JL, Figueroa-Mujíca R, Bermudez D, Corante N, Gaio E, Fox KP, Salomaa V, Havulinna AS, Murray AJ, Malhotra A, Powel FL, Jain M, Komor AC, Cavalleri GL, Huff CD, Villafuerte FC, Simonson TS. PMID: 38335297; PMCID: PMC10857371.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. In vivo macromolecular crowding is differentially modulated by aquaporin 0 in zebrafish lens: Insights from a nanoenvironment sensor and spectral imaging. Sci Adv. 2022 02 18; 8(7):eabj4833. Vorontsova I, Vallmitjana A, Torrado B, Schilling TF, Hall JE, Gratton E, Malacrida L. PMID: 35171678; PMCID: PMC8849302.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    3. Differences in a Single Extracellular Residue Underlie Adhesive Functions of Two Zebrafish Aqp0s. Cells. 2021 08 06; 10(8). Vorontsova I, Hall JE, Schilling TF, Nagai N, Nakazawa Y. PMID: 34440774; PMCID: PMC8392583.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Optical development in the zebrafish eye lens. FASEB J. 2020 04; 34(4):5552-5562. Wang K, Vorontsova I, Hoshino M, Uesugi K, Yagi N, Hall JE, Schilling TF, Pierscionek BK. PMID: 32103543; PMCID: PMC10666921.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    5. Assessment of Zebrafish Lens Nucleus Localization and Sutural Integrity. J Vis Exp. 2019 05 06; (147). Vorontsova I, Hall JE, Schilling TF. PMID: 31107462.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Experimental and Simulation Studies of Aquaporin 0 Water Permeability and Regulation. Chem Rev. 2019 05 08; 119(9):6015-6039. Hall JE, Freites JA, Tobias DJ. PMID: 31026155.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    7. Cooperativity and allostery in aquaporin 0 regulation by Ca2. Biochim Biophys Acta Biomembr. 2019 05 01; 1861(5):988-996. Freites JA, Németh-Cahalan KL, Hall JE, Tobias DJ. PMID: 30802427; PMCID: PMC6437002.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. BFSP1 C-terminal domains released by post-translational processing events can alter significantly the calcium regulation of AQP0 water permeability. Exp Eye Res. 2019 08; 185:107585. Tapodi A, Clemens DM, Uwineza A, Jarrin M, Goldberg MW, Thinon E, Heal WP, Tate EW, Nemeth-Cahalan K, Vorontsova I, Hall JE, Quinlan RA. PMID: 30790544; PMCID: PMC6713518.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    9. Aqp0a Regulates Suture Stability in the Zebrafish Lens. Invest Ophthalmol Vis Sci. 2018 06 01; 59(7):2869-2879. Vorontsova I, Gehring I, Hall JE, Schilling TF. PMID: 30025131; PMCID: PMC5987579.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    10. Calmodulin Gates Aquaporin 0 Permeability through a Positively Charged Cytoplasmic Loop. J Biol Chem. 2017 Jan 06; 292(1):185-195. Fields JB, Németh-Cahalan KL, Freites JA, Vorontsova I, Hall JE, Tobias DJ. PMID: 27660387; PMCID: PMC5217678.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    11. The aquaporin zero puzzle. Biophys J. 2014 Jul 01; 107(1):10-5. Hall JE, Mathias RT. PMID: 24988336; PMCID: PMC4119264.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    12. A junction of transparency. Focus on "Functional effects of Cx50 mutations associated with congenital cataracts". Am J Physiol Cell Physiol. 2014 Feb 01; 306(3):C200-1. Hall JE. PMID: 24133066; PMCID: PMC3919995.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    13. Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci. 2013 Oct 09; 33(41):16310-22. Lioudyno MI, Birch AM, Tanaka BS, Sokolov Y, Goldin AL, Chandy KG, Hall JE, Alkire MT. PMID: 24107962; PMCID: PMC3792466.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    14. In vivo analysis of aquaporin 0 function in zebrafish: permeability regulation is required for lens transparency. Invest Ophthalmol Vis Sci. 2013 Jul 30; 54(7):5136-43. Clemens DM, Németh-Cahalan KL, Trinh L, Zhang T, Schilling TF, Hall JE. PMID: 23800763; PMCID: PMC3729242.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    15. Allosteric mechanism of water-channel gating by Ca2+-calmodulin. Nat Struct Mol Biol. 2013 Sep; 20(9):1085-92. Reichow SL, Clemens DM, Freites JA, Németh-Cahalan KL, Heyden M, Tobias DJ, Hall JE, Gonen T. PMID: 23893133; PMCID: PMC3766450.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    16. Regulation of AQP0 water permeability is enhanced by cooperativity. J Gen Physiol. 2013 Mar; 141(3):287-95. Németh-Cahalan KL, Clemens DM, Hall JE. PMID: 23440275; PMCID: PMC3581697.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    17. Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One. 2012; 7(4):e35090. Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire MT, Liu V, Kozak JA, Dennison PR, Glabe CG, Lösche M, Hall JE. PMID: 22563377; PMCID: PMC3338507.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    18. Through a glass darkly. EMBO Mol Med. 2012 Jan; 4(1):1-2. Hall JE. PMID: 22180285; PMCID: PMC3376833.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    19. Two distinct aquaporin 0s required for development and transparency of the zebrafish lens. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6582-92. Froger A, Clemens D, Kalman K, Németh-Cahalan KL, Schilling TF, Hall JE. PMID: 20671274; PMCID: PMC3055770.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    20. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 2009 Feb 13; 284(7):4230-7. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. PMID: 19098006; PMCID: PMC2640961.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    21. Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity. Biophys J. 2008 Nov 15; 95(10):4845-61. Valincius G, Heinrich F, Budvytyte R, Vanderah DJ, McGillivray DJ, Sokolov Y, Hall JE, Lösche M. PMID: 18515395; PMCID: PMC2576380.
      View in: PubMed   Mentions: 62     Fields:    Translation:Cells
    22. Phosphorylation determines the calmodulin-mediated Ca2+ response and water permeability of AQP0. J Biol Chem. 2008 Jul 25; 283(30):21278-83. Kalman K, Németh-Cahalan KL, Froger A, Hall JE. PMID: 18508773; PMCID: PMC2475685.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    23. Zinc modulation of water permeability reveals that aquaporin 0 functions as a cooperative tetramer. J Gen Physiol. 2007 Nov; 130(5):457-64. Németh-Cahalan KL, Kalman K, Froger A, Hall JE. PMID: 17938229; PMCID: PMC2151666.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. Transformation of plasmid DNA into E. coli using the heat shock method. J Vis Exp. 2007; (6):253. Froger A, Hall JE. PMID: 18997900; PMCID: PMC2557105.
      View in: PubMed   Mentions: 144     Fields:    Translation:Cells
    25. Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J Gen Physiol. 2006 Dec; 128(6):637-47. Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE. PMID: 17101816; PMCID: PMC2151594.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    26. AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0. Biochim Biophys Acta. 2006 Aug; 1758(8):1094-9. Kalman K, Németh-Cahalan KL, Froger A, Hall JE. PMID: 16515771.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    27. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem. 2004 Nov 05; 279(45):46363-6. Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG. PMID: 15385542.
      View in: PubMed   Mentions: 325     Fields:    Translation:HumansCells
    28. Molecular basis of pH and Ca2+ regulation of aquaporin water permeability. J Gen Physiol. 2004 May; 123(5):573-80. Németh-Cahalan KL, Kalman K, Hall JE. PMID: 15078916; PMCID: PMC2234493.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    29. Opening hemichannels in nonjunctional membrane stimulates gap junction formation. Biophys J. 2004 Feb; 86(2):781-96. Beahm DL, Hall JE. PMID: 14747314; PMCID: PMC1303926.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    30. Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. J Biol Chem. 2002 Oct 11; 277(41):38272-83. Nielsen PA, Beahm DL, Giepmans BN, Baruch A, Hall JE, Kumar NM. PMID: 12154091.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    31. Hemichannel and junctional properties of connexin 50. Biophys J. 2002 Apr; 82(4):2016-31. Beahm DL, Hall JE. PMID: 11916859; PMCID: PMC1301997.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
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