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Palczewski, Krzysztof

Title(s)Professor, Ophthalmology
Phone(949) 824-6527
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    Collapse Research 
    Collapse Research Activities and Funding
    Use of systems pharmacology to prevent rod and cone photoreceptor degeneration
    NIH/NEI R24EY027283Mar 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    A two-photon ophthalmoscope for human retinal imaging and functional testing
    NIH/NEI U01EY025451May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Carotenoids in Vision
    NIH/NEI R01EY020551Nov 1, 2009 - Mar 31, 2020
    Role: Co-Principal Investigator
    Visual Sciences Training Program
    NIH/NEI T32EY007157Sep 30, 2000 - May 31, 2022
    Role: Principal Investigator
    Retinoids in Vision
    NIH/NEI R01EY009339Jan 1, 1992 - Aug 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kahremany S, Kubas A, Tochtrop GP, Palczewski K. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jun 20. PMID: 31218312.
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    2. Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 May 23; fj201900443RR. PMID: 31121099.
      View in: PubMed
    3. Mustafi D, Arbabi A, Ameri H, Palczewski K. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17; 12(2). PMID: 31108889.
      View in: PubMed
    4. Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 Jun 14; 294(24):9461-9475. PMID: 31073029.
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    5. Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 May 17; 294(20):8123-8133. PMID: 30948514.
      View in: PubMed
    6. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 Apr 01; 60(5):1538-1546. PMID: 30994864.
      View in: PubMed
    7. Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 Apr 01; 60(5):1442-1453. PMID: 30947334.
      View in: PubMed
    8. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 Feb; 5(2):eaav4322. PMID: 30820458.
      View in: PubMed
    9. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 Apr 12; 294(15):6082-6093. PMID: 30770468.
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    10. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Apr; 33(4):5782-5792. PMID: 30645148.
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    11. Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019; 1834:311-332. PMID: 30324452.
      View in: PubMed
    12. Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019; 1834:333-343. PMID: 30324453.
      View in: PubMed
    13. Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 Mar; 33(3):3680-3692. PMID: 30462532.
      View in: PubMed
    14. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 Jan 09; 39(2):212-223. PMID: 30459230.
      View in: PubMed
    15. Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 Oct 22; 475(20):3171-3188. PMID: 30352831.
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    16. Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 Sep 06; 3(17). PMID: 30185665.
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    17. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 10; 94(4):1132-1144. PMID: 30018116.
      View in: PubMed
    18. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Aug 21; 9(31):6480-6489. PMID: 30310578.
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    19. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. PMID: 29659842.
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    20. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. PMID: 29777099.
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    21. Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 05 17; 9(1):1976. PMID: 29773803.
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    22. Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29; 4:1-19. PMID: 30240733.
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    23. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 Apr 02; 150(4):571-590. PMID: 29500274.
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    24. Luu J, Palczewski K. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):2866-2872. PMID: 29483257.
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    25. Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 05; 93(5):438-452. PMID: 29453250.
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    26. Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 02 13; 57(6):1022-1030. PMID: 29320632.
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    27. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 06; 32(6):3289-3300. PMID: 29401616.
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    28. Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018; 14(7):688-694. PMID: 29651942.
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    29. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb; 364(2):207-220. PMID: 29162627.
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    30. Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 07; 7(1):14623. PMID: 29116131.
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    31. Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Nov 01; 8(11):5228-5242. PMID: 29188116.
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    32. Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9675-E9684. PMID: 29078372.
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    33. Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 12 01; 292(48):19826-19839. PMID: 28978645.
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    34. Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via µ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 11; 38(11):1016-1037. PMID: 28935293.
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    35. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 09; 6(5):6. PMID: 28920007.
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    36. Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov; 26(11):2118-2125. PMID: 28762619.
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    37. Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 10; 60(10):2111-2120. PMID: 28755268.
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    38. Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 05 24; 7(1):2390. PMID: 28539612.
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    39. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. PMID: 28493664.
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    40. Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 06 30; 292(26):10983-10997. PMID: 28487362.
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    41. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 07; 362(1):131-145. PMID: 28476927.
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    42. Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 05 02; 56(17):2338-2348. PMID: 28402104.
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    43. Palczewski K. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct; 124:167-168. PMID: 28363722.
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    44. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. PMID: 28289214.
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    45. Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar; 10069. PMID: 28989217.
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    46. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16; 7:42-52. PMID: 28624218.
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    47. Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 02 24; 292(8):3366-3378. PMID: 28104803.
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    48. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 01 15; 26(2):305-319. PMID: 28065882.
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    49. Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):604-613. PMID: 28129424.
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    50. Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10; 56(1):61-72. PMID: 28045251.
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    51. Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29; 55(47):6545-6557. PMID: 27809489.
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    52. Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Dec 01; 7(12):5148-5169. PMID: 28018732.
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    53. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23; 291(52):26937-26949. PMID: 27875314.
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    54. Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 01; 115:1-13. PMID: 27838510.
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    55. Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 10 15; 25(20):4376-4388. PMID: 28172828.
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    56. Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. PMID: 27720767.
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    57. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 01; 44(21):10467-10479. PMID: 27655633.
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    58. Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4272-81. PMID: 27548901.
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    59. Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 08 22; 55(35):10331-5. PMID: 27460867.
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    60. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. PMID: 27460988.
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    61. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 09 09; 291(37):19401-12. PMID: 27453555.
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    62. Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 10; 2:197-234. PMID: 27917399.
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    63. Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jul 01; 7(7):2671-91. PMID: 27446697.
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    64. Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 07 18; 55(30):8661-5. PMID: 27244650.
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    65. Sears AE, Palczewski K. Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 07; 55(22):3082-91. PMID: 27183166.
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    66. Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. Dominant and recessive mutations in rhodopsin activate different cell death pathways. Hum Mol Genet. 2016 07 01; 25(13):2801-2812. PMID: 27149983.
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    67. Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 06; 12(6):444-51. PMID: 27110679.
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    68. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17; 291(25):12951-9. PMID: 27129240.
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    69. Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15; 499:63-65. PMID: 26851339.
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    70. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15; 11(4):1049-57. PMID: 26811964.
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    71. Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):632-46. PMID: 26903224.
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    72. Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):647-57. PMID: 26903225.
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    73. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18; 290(51):30212-23. PMID: 26499794.
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    74. Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15; 593(22):4923-41. PMID: 26350353.
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    75. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27; 290(48):29035-44. PMID: 26468292.
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    76. Sundermeier TR, Palczewski K. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016 Jan; 30(1):23-33. PMID: 26399786.
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    77. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 06; 290(45):27239-47. PMID: 26391396.
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    78. Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16; 290(42):25728-44. PMID: 26330551.
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    79. Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomed Opt Express. 2015 Sep 01; 6(9):3352-61. PMID: 26417507.
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    80. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. Macromol Biosci. 2015 Dec; 15(12):1663-72. PMID: 26271011.
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    81. Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Aug 01; 6(8):3032-52. PMID: 26309765.
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    82. Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. Serum levels of lipid metabolites in age-related macular degeneration. FASEB J. 2015 Nov; 29(11):4579-88. PMID: 26187344.
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    83. Hofmann L, Palczewski K. Advances in understanding the molecular basis of the first steps in color vision. Prog Retin Eye Res. 2015 Nov; 49:46-66. PMID: 26187035.
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    84. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28; 290(35):21568-79. PMID: 26139608.
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    85. Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4936-42. PMID: 26225634.
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    165. Sundermeier TR, Palczewski K. The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci. 2012 Aug; 69(16):2739-50. PMID: 22460583.
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    186. Jastrzebska B, Palczewski K, Golczak M. Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem. 2011 May 27; 286(21):18930-7. PMID: 21460218.
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    187. Orban T, Palczewska G, Palczewski K. Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem. 2011 May 13; 286(19):17248-58. PMID: 21454509.
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    188. Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods. 2011 May 15; 198(1):70-6. PMID: 21439323.
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    189. Jastrzebska B, Debinski A, Filipek S, Palczewski K. Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res. 2011 Jul; 50(3):267-77. PMID: 21435354.
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    190. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29; 286(17):15543-55. PMID: 21383019.
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    193. Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K. Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem. 2011 Mar 25; 286(12):10551-67. PMID: 21224384.
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    195. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem. 2011 Feb 18; 286(7):5607-13. PMID: 21159775.
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    196. Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar; 25(3):948-59. PMID: 21106934.
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    198. Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov; 128(11):1483-5. PMID: 21060052.
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    200. Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb; 84(2):336-41. PMID: 20881313.
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    201. Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec; 20(12):1643-53. PMID: 20826825.
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    202. Pulagam LP, Palczewski K. Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem. 2010 Sep 17; 285(38):29446-56. PMID: 20628051.
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    203. Golczak M, Palczewski K. An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem. 2010 Sep 17; 285(38):29217-22. PMID: 20628054.
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    204. Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20; 401(3):363-73. PMID: 20600113.
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    205. Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 03; 285(36):27891-9. PMID: 20573961.
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    206. Palczewski K. Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010 Nov; 35(11):595-600. PMID: 20538466.
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    207. Palczewski K. Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun; 31(6):284-95. PMID: 20435355.
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    208. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15; 26(14):1804-5. PMID: 20501551.
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    209. Jastrzebska B, Tsybovsky Y, Palczewski K. Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28; 428(1):1-10. PMID: 20423327.
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    210. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8428-33. PMID: 20404157.
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    211. Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep; 29(5):428-42. PMID: 20304090.
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    212. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul; 35(7):400-10. PMID: 20188572.
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    213. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One. 2010 Feb 19; 5(2):e9312. PMID: 20174477.
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    214. Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 09; 49(5):827-34. PMID: 20047303; PMCID: PMC2819031.
    215. Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb; 25(1):8-15. PMID: 20134024.
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    216. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26; 285(13):9667-82. PMID: 20100834.
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    217. Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13; 18(1):116-26. PMID: 20152158.
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    218. Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun; 24(6):1656-66. PMID: 20061533.
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    219. Golczak M, Bereta G, Maeda A, Palczewski K. Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol. 2010; 652:229-45. PMID: 20552432.
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    220. Imanishi Y, Palczewski K. Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol. 2010; 652:247-61. PMID: 20552433.
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    221. Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010; 703:105-25. PMID: 20711710.
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    222. O'Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E862-70. PMID: 20040693.
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    223. Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr; 24(4):1261-70. PMID: 19940255.
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    225. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17325-30. PMID: 19805034.
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    226. Moise AR, Alvarez S, Domínguez M, Alvarez R, Golczak M, Lobo GP, von Lintig J, de Lera AR, Palczewski K. Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol. 2009 Dec; 76(6):1228-37. PMID: 19770350.
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    227. Kiser PD, Lorimer GH, Palczewski K. Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 01; 65(Pt 10):967-71. PMID: 19851000.
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    228. Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR. Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14367-72. PMID: 19706523; PMCID: PMC2732891.
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    230. Maeda A, Golczak M, Maeda T, Palczewski K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5435-43. PMID: 19553623.
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    231. Jastrzebska B, Goc A, Golczak M, Palczewski K. Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry. 2009 Jun 16; 48(23):5159-70. PMID: 19413332.
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    232. Mustafi D, Engel AH, Palczewski K. Structure of cone photoreceptors. Prog Retin Eye Res. 2009 Jul; 28(4):289-302. PMID: 19501669.
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    236. Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. J Biol Chem. 2009 Jul 10; 284(28):18980-93. PMID: 19423712.
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    237. Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 01; 18(15):2748-60. PMID: 19414487.
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    239. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet. 2009 Jun 15; 18(12):2277-87. PMID: 19339306.
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    243. Baehr W, Palczewski K. Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res. 2009 Jun 15; 89(1):2-3. PMID: 19162008.
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    244. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 Dec 16; 47(50):13296-307. PMID: 19053287.
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    245. Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 01; 18(5):931-41. PMID: 19074458.
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    246. Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 2008 Nov 25; 47(47):12409-19. PMID: 18975915.
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    247. Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem. 2009 Jan 23; 284(4):2472-81. PMID: 19008222.
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    249. Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K. Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J. 2009 Feb; 23(2):371-81. PMID: 18827025.
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    250. Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008 Oct; 48(23-24):2425-32. PMID: 18706439.
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    251. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16; 47(37):9856-65. PMID: 18722466.
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    252. Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K. Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):322-33. PMID: 18708622.
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    254. Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008 Sep 05; 283(36):25091-102. PMID: 18606814.
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    255. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 09; 28(15):4008-14. PMID: 18400900.
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    256. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16; 283(20):13510-9. PMID: 18348983.
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    257. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem. 2008 May 16; 283(20):14053-62. PMID: 18339619.
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    258. Stephen R, Filipek S, Palczewski K, Sousa MC. Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug; 84(4):903-10. PMID: 18346093.
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    259. Müller DJ, Wu N, Palczewski K. Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev. 2008 Mar; 60(1):43-78. PMID: 18321962.
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    260. Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab. 2008 Mar; 7(3):258-68. PMID: 18316031.
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    263. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30; 130(4):1154-5. PMID: 18179220.
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    265. Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L. Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008 Feb 29; 283(9):5611-21. PMID: 18093970.
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    270. Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15123-8. PMID: 17848510.
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    273. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30; 8:177. PMID: 17537266.
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    275. Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K. Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Res. 2007 Jul; 47(15):2055-66. PMID: 17512964.
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    324. Kim TS, Maeda A, Maeda T, Heinlein C, Kedishvili N, Palczewski K, Nelson PS. Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem. 2005 Mar 11; 280(10):8694-704. PMID: 15634683; PMCID: PMC1351245.
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    330. Tu DC, Batten ML, Palczewski K, Van Gelder RN. Nonvisual photoreception in the chick iris. Science. 2004 Oct 01; 306(5693):129-31. PMID: 15459395.
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    377. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78. PMID: 11860507; PMCID: PMC1363676.
    378. Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3294-300. PMID: 11726636.
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    379. McBee JK, Van Hooser JP, Jang GF, Palczewski K. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem. 2001 Dec 21; 276(51):48483-93. PMID: 11604395.
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    391. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 01; 72(2):193-202. PMID: 11401432.
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    392. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22; 171(1-2):111-7. PMID: 11165019.
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    395. McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 2000 Sep 19; 39(37):11370-80. PMID: 10985782.
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    397. Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci. 2000 Sep-Oct; 17(5):667-678. PMID: 11153648; PMCID: PMC1410813.
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    401. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5901-6. PMID: 10811902.
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    409. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. PMID: 10564809.
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    418. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP. Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry. 1999 Mar 02; 38(9):2611-6. PMID: 10052930.
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    428. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5351-6. PMID: 9560279.
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    431. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1271-6. PMID: 9448321.
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    441. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W. The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics. 1997 Feb 01; 39(3):312-22. PMID: 9119368.
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    445. Duda T, Goraczniak R, Surgucheva I, Rudnicka-Nawrot M, Gorczyca WA, Palczewski K, Sitaramayya A, Baehr W, Sharma RK. Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry. 1996 Jul 02; 35(26):8478-82. PMID: 8679607.
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    458. Ohguro H, Palczewski K, Walsh KA, Johnson RS. Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange. Protein Sci. 1994 Dec; 3(12):2428-34. PMID: 7756996.
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    459. Palczewski K, Jäger S, Buczylko J, Crouch RK, Bredberg DL, Hofmann KP, Asson-Batres MA, Saari JC. Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry. 1994 Nov 22; 33(46):13741-50. PMID: 7947785.
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    460. Morrison RS, Shi E, Kan M, Yamaguchi F, McKeehan W, Rudnicka-Nawrot M, Palczewski K. Inositolhexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim. 1994 Nov; 30A(11):783-9. PMID: 7881632.
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    461. Palczewski K. Structure and functions of arrestins. Protein Sci. 1994 Sep; 3(9):1355-61. PMID: 7833798.
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    462. Palczewski K. Is vertebrate phototransduction solved? New insights into the molecular mechanism of phototransduction. Invest Ophthalmol Vis Sci. 1994 Sep; 35(10):3577-81. PMID: 7522225.
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    463. Johnson RS, Ohguro H, Palczewski K, Hurley JB, Walsh KA, Neubert TA. Heterogeneous N-acylation is a tissue- and species-specific posttranslational modification. J Biol Chem. 1994 Aug 19; 269(33):21067-71. PMID: 8063726.
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    464. Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS. Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein. Neuron. 1994 Aug; 13(2):395-404. PMID: 7520254.
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    465. Robinson PR, Buczylko J, Ohguro H, Palczewski K. Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5411-5. PMID: 8202499.
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    466. Smith WC, Milam AH, Dugger D, Arendt A, Hargrave PA, Palczewski K. A splice variant of arrestin. Molecular cloning and localization in bovine retina. J Biol Chem. 1994 Jun 03; 269(22):15407-10. PMID: 7515057.
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    467. Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K. Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):4014-8. PMID: 7909609.
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    468. Gorczyca WA, Van Hooser JP, Palczewski K. Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry. 1994 Mar 22; 33(11):3217-22. PMID: 7511001.
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    469. Polans AS, Palczewski K, Asson-Batres MA, Ohguro H, Witkowska D, Haley TL, Baizer L, Crabb JW. Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina. J Biol Chem. 1994 Feb 25; 269(8):6233-40. PMID: 8119967.
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    470. Ohguro H, Johnson RS, Ericsson LH, Walsh KA, Palczewski K. Control of rhodopsin multiple phosphorylation. Biochemistry. 1994 Feb 01; 33(4):1023-8. PMID: 8305429.
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    471. Palczewski K, Buczylko J, Ohguro H, Annan RS, Carr SA, Crabb JW, Kaplan MW, Johnson RS, Walsh KA. Characterization of a truncated form of arrestin isolated from bovine rod outer segments. Protein Sci. 1994 Feb; 3(2):314-24. PMID: 8003967.
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    472. Pulvermüller A, Palczewski K, Hofmann KP. Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry. 1993 Dec 28; 32(51):14082-8. PMID: 8260489.
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    473. Saari JC, Bredberg DL, Garwin GG, Buczylko J, Wheeler T, Palczewski K. Assays of retinoid dehydrogenases by phase partition. Anal Biochem. 1993 Aug 15; 213(1):128-32. PMID: 8238865.
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    474. Adamus G, Arendt A, Hargrave PA, Heyduk T, Palczewski K. The kinetics of multiphosphorylation of rhodopsin. Arch Biochem Biophys. 1993 Aug 01; 304(2):443-7. PMID: 8346919.
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    475. Ohguro H, Palczewski K, Ericsson LH, Walsh KA, Johnson RS. Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry. 1993 Jun 01; 32(21):5718-24. PMID: 8504090.
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    476. Ohguro H, Chiba S, Igarashi Y, Matsumoto H, Akino T, Palczewski K. Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3241-5. PMID: 8475065.
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    477. Morrison RS, Giordano S, Yamaguchi F, Hendrickson S, Berger MS, Palczewski K. Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells. J Neurosci Res. 1993 Apr 01; 34(5):502-9. PMID: 8478985.
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    478. Palczewski K, Buczylko J, Lebioda L, Crabb JW, Polans AS. Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. J Biol Chem. 1993 Mar 15; 268(8):6004-13. PMID: 8383684.
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    479. Gray-Keller MP, Polans AS, Palczewski K, Detwiler PB. The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron. 1993 Mar; 10(3):523-31. PMID: 8461139.
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    480. Polans AS, Burton MD, Haley TL, Crabb JW, Palczewski K. Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1993 Jan; 34(1):81-90. PMID: 8425844.
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    481. Palczewski K, Buczylko J, Van Hooser P, Carr SA, Huddleston MJ, Crabb JW. Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem. 1992 Sep 15; 267(26):18991-8. PMID: 1527025.
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    482. Hofmann KP, Pulvermüller A, Buczylko J, Van Hooser P, Palczewski K. The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem. 1992 Aug 05; 267(22):15701-6. PMID: 1386362.
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    483. Palczewski K, Riazance-Lawrence JH, Johnson WC. Structural properties of arrestin studied by chemical modification and circular dichroism. Biochemistry. 1992 Apr 28; 31(16):3902-6. PMID: 1567843.
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    484. Palczewski K, Rispoli G, Detwiler PB. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 1992 Jan; 8(1):117-26. PMID: 1309646.
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    485. Palczewski K, Pulvermüller A, Buczylko J, Gutmann C, Hofmann KP. Binding of inositol phosphates to arrestin. FEBS Lett. 1991 Dec 16; 295(1-3):195-9. PMID: 1765153.
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    486. Palczewski K, Pulvermüller A, Buczylko J, Hofmann KP. Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem. 1991 Oct 05; 266(28):18649-54. PMID: 1917988.
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    487. Palczewski K, Benovic JL. G-protein-coupled receptor kinases. Trends Biochem Sci. 1991 Oct; 16(10):387-91. PMID: 1664548.
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    488. Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8715-9. PMID: 1656454.
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    489. Palczewski K, Buczylko J, Imami NR, McDowell JH, Hargrave PA. Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin. J Biol Chem. 1991 Aug 15; 266(23):15334-9. PMID: 1651326.
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    490. Palczewski K, Buczylko J, Kaplan MW, Polans AS, Crabb JW. Mechanism of rhodopsin kinase activation. J Biol Chem. 1991 Jul 15; 266(20):12949-55. PMID: 2071581.
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    491. Ragazzi E, Shryock J, Palczewski K. Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. Pharmacol Res. 1991 Jul; 24(1):15-23. PMID: 1946140.
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    492. Palczewski K, Farber DB, Hargrave PA. Elevated level of protein phosphatase 2A activity in retinas of rd mice. Exp Eye Res. 1991 Jul; 53(1):101-5. PMID: 1652453.
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    493. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry. 1991 May 28; 30(21):5118-25. PMID: 1645191.
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    494. Buczylko J, Gutmann C, Palczewski K. Regulation of rhodopsin kinase by autophosphorylation. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2568-72. PMID: 2006192.
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    495. Palczewski K, Hargrave PA. Studies of ligand binding to arrestin. J Biol Chem. 1991 Mar 05; 266(7):4201-6. PMID: 1999413.
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    496. Polans AS, Buczylko J, Crabb J, Palczewski K. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. J Cell Biol. 1991 Mar; 112(5):981-9. PMID: 1999465.
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    497. Adamus G, Zam ZS, Arendt A, Palczewski K, McDowell JH, Hargrave PA. Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res. 1991; 31(1):17-31. PMID: 2006550.
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    498. Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 1990 Oct 30; 29(43):10102-6. PMID: 2271641.
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    499. Palczewski K, Kahn N, Hargrave PA. Nucleoside inhibitors of rhodopsin kinase. Biochemistry. 1990 Jul 03; 29(26):6276-82. PMID: 2207073.
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    500. Lebioda L, Hargrave PA, Palczewski K. X-ray crystal structure of sangivamycin, a potent inhibitor of protein kinases. FEBS Lett. 1990 Jun 18; 266(1-2):102-4. PMID: 2365059.
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    501. Litchfield DW, Arendt A, Lozeman FJ, Krebs EG, Hargrave PA, Palczewski K. Synthetic phosphopeptides are substrates for casein kinase II. FEBS Lett. 1990 Feb 12; 261(1):117-20. PMID: 2307228.
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    502. Palczewski K, Carruth ME, Adamus G, McDowell JH, Hargrave PA. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 1990; 30(8):1129-37. PMID: 2402884.
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    503. Palczewski K, Arendt A, McDowell JH, Hargrave PA. Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry. 1989 Oct 31; 28(22):8764-70. PMID: 2605220.
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    504. Palczewski K, McDowell JH, Jakes S, Ingebritsen TS, Hargrave PA. Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem. 1989 Sep 25; 264(27):15770-3. PMID: 2550422.
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    505. Arendt A, Palczewski K, Moore WT, Caprioli RM, McDowell JH, Hargrave PA. Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. Int J Pept Protein Res. 1989 Jun; 33(6):468-76. PMID: 2506143.
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    506. Palczewski K, Hargrave PA, McDowell JH, Ingebritsen TS. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry. 1989 Jan 24; 28(2):415-9. PMID: 2540796.
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    507. Palczewski K, McDowell JH, Hargrave PA. Purification and characterization of rhodopsin kinase. J Biol Chem. 1988 Oct 05; 263(28):14067-73. PMID: 2844754.
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    508. Palczewski K, McDowell JH, Hargrave PA. Rhodopsin kinase: substrate specificity and factors that influence activity. Biochemistry. 1988 Apr 05; 27(7):2306-13. PMID: 3382623.
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    509. Palczewski K, Kochman M. Photoaffinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 8-azido-1,N6-ethenoadenosine 5'-triphosphate. Biochemistry. 1987 Jun 16; 26(12):3466-71. PMID: 3651392.
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    510. Palczewski K, Hargrave PA, Folta EJ, Kochman M. Affinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. Eur J Biochem. 1985 Jan 15; 146(2):309-14. PMID: 3967660.
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    511. Palczewski K, Hargrave PA, Kochman M. o-Phthalaldehyde, a fluorescence probe of aldolase active site. Eur J Biochem. 1983 Dec 15; 137(3):429-35. PMID: 6662105.
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