Krzysztof Palczewski

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6527
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    Collapse Research 
    Collapse Research Activities and Funding
    The complex role of phosphodiesterase 6 in rod photoreceptor health and function
    NIH R01EY030873Sep 1, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Opsin signaling in mammalian rod photoreceptors
    NIH R01EY030912Jun 1, 2020 - May 31, 2024
    Role: Co-Principal Investigator
    Use of systems pharmacology to prevent rod and cone photoreceptor degeneration
    NIH R24EY027283Jul 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    A two-photon ophthalmoscope for human retinal imaging and functional testing
    NIH U01EY025451May 1, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Regulation of Retinal Physiology by micro-RNAs
    NIH R01EY022326Mar 1, 2013 - Feb 28, 2018
    Role: Principal Investigator
    Carotenoids in Vision
    NIH R01EY020551Nov 1, 2009 - Apr 30, 2025
    Role: Co-Principal Investigator
    Visual Sciences Training Program
    NIH T32EY007157Sep 30, 2000 - May 31, 2022
    Role: Principal Investigator
    Retinoids in Vision
    NIH R01EY009339Jan 1, 1992 - Aug 31, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Retinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa. Mol Cell Proteomics. 2024 Nov; 23(11):100855. Montaser AB, Gao F, Peters D, Vainionpää K, Zhibin N, Skowronska-Krawczyk D, Figeys D, Palczewski K, Leinonen H. PMID: 39389360; PMCID: PMC11602984.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2024 Oct 08; 121(41):e2414037121. Krishnamoorthi A, Salom D, Wu A, Palczewski K, Rentzepis PM. PMID: 39356673; PMCID: PMC11474067.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. The Impact of Nanobodies on G Protein-Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents. Mol Pharmacol. 2024 Sep 17; 106(4):155-163. Salom D, Wu A, Liu CC, Palczewski K. PMID: 39107078; PMCID: PMC11413913.
      View in: PubMed   Mentions:    Fields:    
    4. A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nat Commun. 2024 Jul 15; 15(1):5943. Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. PMID: 39009597; PMCID: PMC11251169.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration. J Biol Chem. 2024 Jun; 300(6):107344. Du SW, Komirisetty R, Lewandowski D, Choi EH, Panas D, Suh S, Tabaka M, Radu RA, Palczewski K. PMID: 38705389; PMCID: PMC11140208.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 05 28; 43(5):114143. Bassetto M, Kolesnikov AV, Lewandowski D, Kiser JZ, Halabi M, Einstein DE, Choi EH, Palczewski K, Kefalov VJ, Kiser PD. PMID: 38676924; PMCID: PMC11211020.
      View in: PubMed   Mentions: 1     Fields:    
    7. Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice. J Biol Chem. 2024 May; 300(5):107291. Lewandowski D, Gao F, Imanishi S, Tworak A, Bassetto M, Dong Z, Pinto AFM, Tabaka M, Kiser PD, Imanishi Y, Skowronska-Krawczyk D, Palczewski K. PMID: 38636661; PMCID: PMC11107370.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. In Memoriam: M. Cristina Kenney, MD, PhD (1949-2023). Exp Eye Res. 2024 Jan 31; 109805. Kuppermann BD, Palczewski K. PMID: 38302293.
      View in: PubMed   Mentions:    Fields:    
    9. Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins. J Biol Chem. 2024 Mar; 300(3):105678. Hong JD, Salom D, Choi EH, Du SW, Tworak A, Smidak R, Gao F, Solano YJ, Zhang J, Kiser PD, Palczewski K. PMID: 38272218; PMCID: PMC10877631.
      View in: PubMed   Mentions: 2     Fields:    
    10. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nat Biotechnol. 2024 Oct; 42(10):1526-1537. An M, Raguram A, Du SW, Banskota S, Davis JR, Newby GA, Chen PZ, Palczewski K, Liu DR. PMID: 38191664; PMCID: PMC11228131.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    11. Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice. J Alzheimers Dis. 2024; 97(2):927-937. Gao J, Leinonen H, Wang EJ, Ding M, Perry G, Palczewski K, Wang X. PMID: 38143367; PMCID: PMC11174142.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses. Proc Natl Acad Sci U S A. 2023 Dec 12; 120(50):e2314698120. Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Placzkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K. PMID: 38064509; PMCID: PMC10723050.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 2023 08 25; 14(1):5209. Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K. PMID: 37626045; PMCID: PMC10457330.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    14. Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. Cell Rep. 2023 08 29; 42(8):112982. Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. PMID: 37585292; PMCID: PMC10530494.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Genome editing in the treatment of ocular diseases. Exp Mol Med. 2023 08; 55(8):1678-1690. Choi EH, Suh S, Sears AE, Holubowicz R, Kedhar SR, Browne AW, Palczewski K. PMID: 37524870; PMCID: PMC10474087.
      View in: PubMed   Mentions: 7     Fields:    
    16. A short story on how chromophore is hydrolyzed from rhodopsin for recycling. Bioessays. 2023 09; 45(9):e2300068. Hong JD, Palczewski K. PMID: 37454357; PMCID: PMC10614701.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Saving eyesight, one gene at a time. Trends Mol Med. 2023 Jul; 29(7):484-486. Holubowicz R, Palczewski K. PMID: 37169661; PMCID: PMC10521062.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    18. Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2221045120. Luu JC, Saadane A, Leinonen H, Choi EH, Gao F, Lewandowski D, Halabi M, Sander CL, Wu A, Wang JM, Singh R, Gao S, Lessieur EM, Dong Z, Palczewska G, Mullins RF, Peachey NS, Kiser PD, Tabaka M, Kern TS, Palczewski K. PMID: 37126699; PMCID: PMC10175720.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. In vivo imaging of the human retina using a two-photon excited fluorescence ophthalmoscope. STAR Protoc. 2023 Apr 13; 4(2):102225. Boguslawski J, Tomczewski S, Dabrowski M, Komar K, Milkiewicz J, Palczewska G, Palczewski K, Wojtkowski M. PMID: 37058404; PMCID: PMC10140148.
      View in: PubMed   Mentions: 3     Fields:    
    20. Eye on genome editing. J Exp Med. 2023 05 01; 220(5). Du SW, Palczewski K. PMID: 36930175; PMCID: PMC10035435.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Investigating the Role of Rhodopsin F45L Mutation in Mouse Rod Photoreceptor Signaling and Survival. eNeuro. 2023 03; 10(3). Poria D, Kolesnikov AV, Lee TJ, Salom D, Palczewski K, Kefalov VJ. PMID: 36823167; PMCID: PMC9997694.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Genome editing, a superior therapy for inherited retinal diseases. Vision Res. 2023 05; 206:108192. Yan AL, Du SW, Palczewski K. PMID: 36804635; PMCID: PMC10460145.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    23. From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation. Prog Retin Eye Res. 2023 03; 93:101170. Palczewska G, Wojtkowski M, Palczewski K. PMID: 36787681; PMCID: PMC10463242.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2214276120. Dhankhar D, Salom D, Palczewski K, Rentzepis PM. PMID: 36577071; PMCID: PMC9910472.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2213911119. Hong JD, Salom D, Kochman MA, Kubas A, Kiser PD, Palczewski K. PMID: 36322748; PMCID: PMC9659404.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    26. Structural view of G protein-coupled receptor signaling in the retinal rod outer segment. Trends Biochem Sci. 2023 02; 48(2):172-186. Gulati S, Palczewski K. PMID: 36163145; PMCID: PMC9868064.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    27. Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration. Curr Biol. 2022 10 24; 32(20):4538-4546.e5. Huh CYL, Leinonen H, Nakayama T, Tomasello JR, Zhang J, Zeitoun J, Peach JP, Halabi M, Kiser JZ, Palczewski K, Kiser PD, Gandhi SP. PMID: 36152631; PMCID: PMC10083103.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    28. Precision genome editing in the eye. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2210104119. Suh S, Choi EH, Raguram A, Liu DR, Palczewski K. PMID: 36122230; PMCID: PMC9522375.
      View in: PubMed   Mentions: 16     Fields:    
    29. Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles. Mol Ther Nucleic Acids. 2022 Sep 13; 29:823-835. Sun D, Sun W, Gao SQ, Lehrer J, Naderi A, Wei C, Lee S, Schilb AL, Scheidt J, Hall RC, Traboulsi EI, Palczewski K, Lu ZR. PMID: 36159595; PMCID: PMC9463552.
      View in: PubMed   Mentions: 14  
    30. Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice. Invest Ophthalmol Vis Sci. 2022 07 08; 63(8):18. Kolesnikov AV, Luu J, Jin H, Palczewski K, Kefalov VJ. PMID: 35861670; PMCID: PMC9315073.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 May-Jun; 9(3). Leinonen H, Lyon DC, Palczewski K, Foik AT. PMID: 35701168; PMCID: PMC9239850.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    32. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2022 04 22; 31(8):1263-1277. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, 99 Lives Consortium, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. PMID: 34726233; PMCID: PMC9029234.
      View in: PubMed   Mentions: 4     Fields:    
    33. Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Cells. 2022 04 13; 11(8). Tarban N, Halász H, Gogolák P, Garabuczi É, Moise AR, Palczewski K, Sarang Z, Szondy Z. PMID: 35456012; PMCID: PMC9028072.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    34. Capturing a rhodopsin receptor signalling cascade across a native membrane. Nature. 2022 04; 604(7905):384-390. Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV. PMID: 35388214; PMCID: PMC9007743.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    35. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 04 05; 13(1):1830. Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. PMID: 35383196; PMCID: PMC8983734.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 02 22; 7(4). Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. PMID: 35015730; PMCID: PMC8876453.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope. J Clin Invest. 2022 01 18; 132(2). Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Gluszek A, Laszczych Z, Karnowski K, Sobon G, Palczewski K, Wojtkowski M. PMID: 34847075; PMCID: PMC8759795.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    38. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022 01 20; 185(2):250-265.e16. Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. PMID: 35021064; PMCID: PMC8809250.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    39. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 01 08; 20(1):21. Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. PMID: 34998409; PMCID: PMC8742393.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Determinants shaping the nanoscale architecture of the mouse rod outer segment. Elife. 2021 12 21; 10. Pöge M, Mahamid J, Imanishi SS, Plitzko JM, Palczewski K, Baumeister W. PMID: 34931611; PMCID: PMC8758146.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    41. Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 12; 297(6):101401. Getter T, Kemp A, Vinberg F, Palczewski K. PMID: 34774799; PMCID: PMC8665362.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. MicroRNA regulation of critical retinal pigment epithelial functions. Trends Neurosci. 2022 01; 45(1):78-90. Du SW, Palczewski K. PMID: 34753606; PMCID: PMC9066699.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    43. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022 02 03; 30(2):263-277.e5. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. PMID: 34678158; PMCID: PMC8818024.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    44. Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. J Phys Chem A. 2021 Sep 30; 125(38):8358-8372. Kochman MA, Palczewski K, Kubas A. PMID: 34546761; PMCID: PMC8488936.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    45. Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies. Mol Pharmacol. 2021 11; 100(5):470-479. Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. PMID: 34393108; PMCID: PMC9175131.
      View in: PubMed   Mentions: 8     Fields:    
    46. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 08 02; 220(8). Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. PMID: 34132745; PMCID: PMC8240855.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    47. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 06 24; 64(12):8287-8302. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. PMID: 34081480; PMCID: PMC8381290.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    48. THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY: A Pilot Study. Retina. 2021 Jun 01; 41(6):1302-1308. Labuz G, Rayamajhi A, Khoramnia R, Palczewska G, Palczewski K, Holschbach A, Auffarth GU. PMID: 33323904; PMCID: PMC8137510.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    49. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 05 10; 6(9). Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. PMID: 33784255; PMCID: PMC8262343.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    50. New focus on regulation of the rod photoreceptor phosphodiesterase. Curr Opin Struct Biol. 2021 08; 69:99-107. Gulati S, Palczewski K. PMID: 33945959; PMCID: PMC8405451.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    51. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 07; 378(1):31-41. Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. PMID: 33931547; PMCID: PMC8456514.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    52. Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjug Chem. 2021 03 17; 32(3):572-583. Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. PMID: 33677964; PMCID: PMC8087159.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    53. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor. J Lipid Res. 2021; 62:100040. Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. PMID: 32493732; PMCID: PMC7910522.
      View in: PubMed   Mentions: 21     Fields:    
    54. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 01 04; 153(1). Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. PMID: 33216847; PMCID: PMC7685772.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 02 10; 330:329-340. Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. PMID: 33358976; PMCID: PMC9066847.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    56. Two-photon microperimetry with picosecond pulses. Biomed Opt Express. 2021 Jan 01; 12(1):462-479. Marzejon MJ, Kornaszewski L, Boguslawski J, Ciacka P, Martynow M, Palczewska G, Mackowski S, Palczewski K, Wojtkowski M, Komar K. PMID: 33659083; PMCID: PMC7899501.
      View in: PubMed   Mentions: 8  
    57. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun; 296:100072. Kiser PD, Palczewski K. PMID: 33187985; PMCID: PMC7948990.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    58. PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153. Blood. 2020 11 05; 136(19):2217-2228. Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K, INVENT Consortium, Nieman MT. PMID: 32575122; PMCID: PMC7645988.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    59. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2020 Nov; 4(11):1119. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33122854.
      View in: PubMed   Mentions: 1     Fields:    
    60. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 02; 5(2):169-178. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33077938; PMCID: PMC7885272.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
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    375. Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 2006 Jun; 3(6):e201. Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. PMID: 16700630; PMCID: PMC1463903.
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    416. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004 Aug; 59(2):204-217. Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. PMID: 15486694; PMCID: PMC1351297.
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    426. Phototransduction: crystal clear. Trends Biochem Sci. 2003 Sep; 28(9):479-87. Ridge KD, Abdulaev NG, Sousa M, Palczewski K. PMID: 13678959.
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    427. Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina. 2003 Aug; 23(4):543-6. Marmor MF, Haeseleer F, Palczewski K. PMID: 12972770.
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    428. Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res. 2003 Jul; 22(4):417-34. Maeda T, Imanishi Y, Palczewski K. PMID: 12742390.
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    429. Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem. 2003 May; 85(4):944-56. Maeda T, Van Hooser JP, Driessen CA, Filipek S, Janssen JJ, Palczewski K. PMID: 12716426; PMCID: PMC1435694.
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    430. Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. J Biol Chem. 2003 Jul 04; 278(27):24896-24903. Schädel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP. PMID: 12707280; PMCID: PMC1360283.
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    432. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003 Mar 18; 42(10):2759-67. Mirzadegan T, Benkö G, Filipek S, Palczewski K. PMID: 12627940; PMCID: PMC1435692.
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    433. Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2290-5. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. PMID: 12601165; PMCID: PMC151333.
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    438. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem. 2003 Mar 07; 278(10):8316-25. Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. PMID: 12499365.
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    440. Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochim Biophys Acta. 2002 Oct 11; 1565(2):168-82. Stenkamp RE, Filipek S, Driessen CA, Teller DC, Palczewski K. PMID: 12409193.
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    444. Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol. 2002 Aug; 32(8):2300-7. Maeda A, Maeda T, Ohguro H, Palczewski K, Sato N. PMID: 12209643.
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    447. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J. 2002 Apr 02; 21(7):1545-54. Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. PMID: 11927539; PMCID: PMC125366.
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    450. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun. 2002 Jan 18; 290(2):615-23. Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. PMID: 11785943.
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    451. Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry. 2002 Jan 08; 41(1):251-7. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K. PMID: 11772023; PMCID: PMC1363675.
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    454. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002; 514:303-17. Haeseleer F, Palczewski K. PMID: 12596929.
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    460. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9948-53. Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. PMID: 11493703; PMCID: PMC55558.
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    470. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22; 171(1-2):111-7. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. PMID: 11165019.
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    484. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol. 2000; 316:359-71. Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. PMID: 10800687; PMCID: PMC1552099.
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    485. Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000; 316:372-83. Haeseleer F, Palczewski K. PMID: 10800688.
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    486. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods Enzymol. 2000; 316:436-51. Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR, Palczewski K, Gelb MH. PMID: 10800693; PMCID: PMC1435690.
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    487. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. PMID: 10564809.
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    488. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12; 38(41):13542-50. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. PMID: 10521261.
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    493. beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem. 1999 May 07; 274(19):12984-9. Mukherjee S, Palczewski K, Gurevich VV, Hunzicker-Dunn M. PMID: 10224047.
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    496. Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry. 1999 Mar 02; 38(9):2611-6. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP. PMID: 10052930.
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    498. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):493-8. Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. PMID: 9892661; PMCID: PMC15164.
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    501. Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol. 1998 Dec; 68(6):824-8. Ohguro H, Yoshida N, Shindou H, Crabb JW, Palczewski K, Tsuda M. PMID: 9867032.
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    506. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5351-6. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. PMID: 9560279; PMCID: PMC20264.
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    528. Alligator rhodopsin: sequence and biochemical properties. Exp Eye Res. 1995 Nov; 61(5):569-78. Smith WC, Adamus G, Van Der Wel H, Timmers A, Palczewski K, Ulshafer RJ, Hargrave PA, McDowell JH. PMID: 8654500.
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    556. Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. J Biol Chem. 1993 Mar 15; 268(8):6004-13. Palczewski K, Buczylko J, Lebioda L, Crabb JW, Polans AS. PMID: 8383684.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    557. The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron. 1993 Mar; 10(3):523-31. Gray-Keller MP, Polans AS, Palczewski K, Detwiler PB. PMID: 8461139.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    558. Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1993 Jan; 34(1):81-90. Polans AS, Burton MD, Haley TL, Crabb JW, Palczewski K. PMID: 8425844.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    559. Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem. 1992 Sep 15; 267(26):18991-8. Palczewski K, Buczylko J, Van Hooser P, Carr SA, Huddleston MJ, Crabb JW. PMID: 1527025.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    560. The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem. 1992 Aug 05; 267(22):15701-6. Hofmann KP, Pulvermüller A, Buczylko J, Van Hooser P, Palczewski K. PMID: 1386362.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    561. Structural properties of arrestin studied by chemical modification and circular dichroism. Biochemistry. 1992 Apr 28; 31(16):3902-6. Palczewski K, Riazance-Lawrence JH, Johnson WC. PMID: 1567843.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    562. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 1992 Jan; 8(1):117-26. Palczewski K, Rispoli G, Detwiler PB. PMID: 1309646.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    563. Binding of inositol phosphates to arrestin. FEBS Lett. 1991 Dec 16; 295(1-3):195-9. Palczewski K, Pulvermüller A, Buczylko J, Gutmann C, Hofmann KP. PMID: 1765153.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    564. Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem. 1991 Oct 05; 266(28):18649-54. Palczewski K, Pulvermüller A, Buczylko J, Hofmann KP. PMID: 1917988.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    565. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8715-9. Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ. PMID: 1656454; PMCID: PMC52580.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    566. G-protein-coupled receptor kinases. Trends Biochem Sci. 1991 Oct; 16(10):387-91. Palczewski K, Benovic JL. PMID: 1664548.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    567. Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin. J Biol Chem. 1991 Aug 15; 266(23):15334-9. Palczewski K, Buczylko J, Imami NR, McDowell JH, Hargrave PA. PMID: 1651326.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    568. Mechanism of rhodopsin kinase activation. J Biol Chem. 1991 Jul 15; 266(20):12949-55. Palczewski K, Buczylko J, Kaplan MW, Polans AS, Crabb JW. PMID: 2071581.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    569. Elevated level of protein phosphatase 2A activity in retinas of rd mice. Exp Eye Res. 1991 Jul; 53(1):101-5. Palczewski K, Farber DB, Hargrave PA. PMID: 1652453.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    570. Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. Pharmacol Res. 1991 Jul; 24(1):15-23. Ragazzi E, Shryock J, Palczewski K. PMID: 1946140.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    571. Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry. 1991 May 28; 30(21):5118-25. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. PMID: 1645191.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    572. Regulation of rhodopsin kinase by autophosphorylation. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2568-72. Buczylko J, Gutmann C, Palczewski K. PMID: 2006192; PMCID: PMC51274.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    573. Studies of ligand binding to arrestin. J Biol Chem. 1991 Mar 05; 266(7):4201-6. Palczewski K, Hargrave PA. PMID: 1999413.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    574. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. J Cell Biol. 1991 Mar; 112(5):981-9. Polans AS, Buczylko J, Crabb J, Palczewski K. PMID: 1999465; PMCID: PMC2288874.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    575. Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res. 1991; 31(1):17-31. Adamus G, Zam ZS, Arendt A, Palczewski K, McDowell JH, Hargrave PA. PMID: 2006550.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    576. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 1990 Oct 30; 29(43):10102-6. Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. PMID: 2271641.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    577. Nucleoside inhibitors of rhodopsin kinase. Biochemistry. 1990 Jul 03; 29(26):6276-82. Palczewski K, Kahn N, Hargrave PA. PMID: 2207073.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    578. X-ray crystal structure of sangivamycin, a potent inhibitor of protein kinases. FEBS Lett. 1990 Jun 18; 266(1-2):102-4. Lebioda L, Hargrave PA, Palczewski K. PMID: 2365059.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    579. Synthetic phosphopeptides are substrates for casein kinase II. FEBS Lett. 1990 Feb 12; 261(1):117-20. Litchfield DW, Arendt A, Lozeman FJ, Krebs EG, Hargrave PA, Palczewski K. PMID: 2307228.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    580. Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 1990; 30(8):1129-37. Palczewski K, Carruth ME, Adamus G, McDowell JH, Hargrave PA. PMID: 2402884.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    581. Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry. 1989 Oct 31; 28(22):8764-70. Palczewski K, Arendt A, McDowell JH, Hargrave PA. PMID: 2605220.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    582. Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem. 1989 Sep 25; 264(27):15770-3. Palczewski K, McDowell JH, Jakes S, Ingebritsen TS, Hargrave PA. PMID: 2550422.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    583. Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. Int J Pept Protein Res. 1989 Jun; 33(6):468-76. Arendt A, Palczewski K, Moore WT, Caprioli RM, McDowell JH, Hargrave PA. PMID: 2506143.
      View in: PubMed   Mentions: 2     Fields:    
    584. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry. 1989 Jan 24; 28(2):415-9. Palczewski K, Hargrave PA, McDowell JH, Ingebritsen TS. PMID: 2540796.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    585. Purification and characterization of rhodopsin kinase. J Biol Chem. 1988 Oct 05; 263(28):14067-73. Palczewski K, McDowell JH, Hargrave PA. PMID: 2844754.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    586. Rhodopsin kinase: substrate specificity and factors that influence activity. Biochemistry. 1988 Apr 05; 27(7):2306-13. Palczewski K, McDowell JH, Hargrave PA. PMID: 3382623.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    587. Photoaffinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 8-azido-1,N6-ethenoadenosine 5'-triphosphate. Biochemistry. 1987 Jun 16; 26(12):3466-71. Palczewski K, Kochman M. PMID: 3651392.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    588. Affinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. Eur J Biochem. 1985 Jan 15; 146(2):309-14. Palczewski K, Hargrave PA, Folta EJ, Kochman M. PMID: 3967660.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    589. o-Phthalaldehyde, a fluorescence probe of aldolase active site. Eur J Biochem. 1983 Dec 15; 137(3):429-35. Palczewski K, Hargrave PA, Kochman M. PMID: 6662105.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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