Krzysztof Palczewski

Title(s)Professor, Ophthalmology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6527
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    Collapse Research 
    Collapse Research Activities and Funding
    The complex role of phosphodiesterase 6 in rod photoreceptor health and function
    NIH R01EY030873Sep 1, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Opsin signaling in mammalian rod photoreceptors
    NIH R01EY030912Jun 1, 2020 - May 31, 2024
    Role: Co-Principal Investigator
    Use of systems pharmacology to prevent rod and cone photoreceptor degeneration
    NIH R24EY027283Jul 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    A two-photon ophthalmoscope for human retinal imaging and functional testing
    NIH U01EY025451May 1, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Regulation of Retinal Physiology by micro-RNAs
    NIH R01EY022326Mar 1, 2013 - Feb 28, 2018
    Role: Principal Investigator
    Carotenoids in Vision
    NIH R01EY020551Nov 1, 2009 - Apr 30, 2025
    Role: Co-Principal Investigator
    Visual Sciences Training Program
    NIH T32EY007157Sep 30, 2000 - May 31, 2022
    Role: Principal Investigator
    Retinoids in Vision
    NIH R01EY009339Jan 1, 1992 - Aug 31, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope. J Clin Invest. 2022 Jan 18; 132(2). Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Gluszek A, Laszczych Z, Karnowski K, Sobon G, Palczewski K, Wojtkowski M. PMID: 34847075; PMCID: PMC8759795.
      View in: PubMed   Mentions:
    2. Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 Jan 11. Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu JC, Lee JY, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. PMID: 35015730.
      View in: PubMed   Mentions:
    3. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 Jan 08; 20(1):21. Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. PMID: 34998409; PMCID: PMC8742393.
      View in: PubMed   Mentions:
    4. Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022 Jan 07. Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. PMID: 35021064.
      View in: PubMed   Mentions:
    5. Determinants shaping the nanoscale architecture of the mouse rod outer segment. Elife. 2021 12 21; 10. Pöge M, Mahamid J, Imanishi SS, Plitzko JM, Palczewski K, Baumeister W. PMID: 34931611; PMCID: PMC8758146.
      View in: PubMed   Mentions:
    6. Identification of small molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 Nov 11; 101401. Getter T, Kemp A, Vinberg F, Palczewski K. PMID: 34774799.
      View in: PubMed   Mentions:
    7. MicroRNA regulation of critical retinal pigment epithelial functions. Trends Neurosci. 2021 Nov 06. Du SW, Palczewski K. PMID: 34753606.
      View in: PubMed   Mentions:
    8. A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2021 Nov 02. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. PMID: 34726233.
      View in: PubMed   Mentions:
    9. Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2021 Oct 21. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. PMID: 34678158.
      View in: PubMed   Mentions:    Fields:    
    10. Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. J Phys Chem A. 2021 Sep 30; 125(38):8358-8372. Kochman MA, Palczewski K, Kubas A. PMID: 34546761; PMCID: PMC8488936.
      View in: PubMed   Mentions:    Fields:    
    11. Regulation of adrenergic, serotonin and dopamine receptors to inhibit diabetic retinopathy: monotherapies versus combination therapies. Mol Pharmacol. 2021 Aug 15. Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. PMID: 34393108.
      View in: PubMed   Mentions:    Fields:    
    12. Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 08 02; 220(8). Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. PMID: 34132745; PMCID: PMC8240855.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 06 24; 64(12):8287-8302. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. PMID: 34081480; PMCID: PMC8381290.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY: A Pilot Study. Retina. 2021 Jun 01; 41(6):1302-1308. Labuz G, Rayamajhi A, Khoramnia R, Palczewska G, Palczewski K, Holschbach A, Auffarth GU. PMID: 33323904; PMCID: PMC8137510.
      View in: PubMed   Mentions:    Fields:    
    15. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 May 10; 6(9). Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. PMID: 33784255; PMCID: PMC8262343.
      View in: PubMed   Mentions:    Fields:    
    16. New focus on regulation of the rod photoreceptor phosphodiesterase. Curr Opin Struct Biol. 2021 08; 69:99-107. Gulati S, Palczewski K. PMID: 33945959; PMCID: PMC8405451.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    17. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 Jul; 378(1):31-41. Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. PMID: 33931547; PMCID: PMC8456514.
      View in: PubMed   Mentions: 1     Fields:    
    18. Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjug Chem. 2021 03 17; 32(3):572-583. Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. PMID: 33677964; PMCID: PMC8087159.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    19. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor. J Lipid Res. 2021 Feb 06; 62:100040. Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. PMID: 32493732; PMCID: PMC7910522.
      View in: PubMed   Mentions: 3     Fields:    
    20. Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 01 04; 153(1). Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. PMID: 33216847; PMCID: PMC7685772.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 02 10; 330:329-340. Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. PMID: 33358976.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Two-photon microperimetry with picosecond pulses. Biomed Opt Express. 2021 Jan 01; 12(1):462-479. Marzejon MJ, Kornaszewski L, Boguslawski J, Ciacka P, Martynow M, Palczewska G, Mackowski S, Palczewski K, Wojtkowski M, Komar K. PMID: 33659083; PMCID: PMC7899501.
      View in: PubMed   Mentions:
    23. Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun; 296:100072. Kiser PD, Palczewski K. PMID: 33187985; PMCID: PMC7948990.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    24. PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153. Blood. 2020 11 05; 136(19):2217-2228. Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K, INVENT Consortium, Nieman MT. PMID: 32575122; PMCID: PMC7645988.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    25. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2020 Nov; 4(11):1119. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33122854.
      View in: PubMed   Mentions: 2     Fields:    
    26. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 02; 5(2):169-178. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33077938; PMCID: PMC7885272.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 09 22; 9. Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. PMID: 32960171; PMCID: PMC7529457.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    28. Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Hum Mol Genet. 2020 08 29; 29(15):2611-2624. Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K. PMID: 32691052; PMCID: PMC7471509.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    29. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 10; 34(10):13918-13934. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. PMID: 32860273; PMCID: PMC7589273.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    30. Noninvasive two-photon optical biopsy of retinal fluorophores. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22532-22543. Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K. PMID: 32848058; PMCID: PMC7486747.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19629-19638. Palczewski K, Kiser PD. PMID: 32759209; PMCID: PMC7443880.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    32. Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorg Med Chem Lett. 2020 09 15; 30(18):127421. Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. PMID: 32717613; PMCID: PMC7494577.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    33. Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity. Transl Vis Sci Technol. 2020 07; 9(8):7. Labuz G, Rayamajhi A, Usinger J, Komar K, Merz P, Khoramnia R, Palczewska G, Palczewski K, Auffarth GU. PMID: 32855854; PMCID: PMC7422764.
      View in: PubMed   Mentions: 1  Translation:HumansCells
    34. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9922-9931. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, Liu Q, Boldt K, Wolfrum U, Ueffing M, Garanto A, Roepman R, Collin RWJ. PMID: 32312818; PMCID: PMC7211956.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. ACS Appl Bio Mater. 2020 May 18; 3(5):3078-3086. Sun D, Schur RM, Sears AE, Gao SQ, Sun W, Naderi A, Kern T, Palczewski K, Lu ZR. PMID: 34327311; PMCID: PMC8317636.
      View in: PubMed   Mentions:
    36. Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PLoS One. 2020; 15(4):e0228121. Valdez-Lopez JC, Gulati S, Ortiz EA, Palczewski K, Robinson PR. PMID: 32236094; PMCID: PMC7112210.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules. 2019 11 13; 9(11). Sarang Z, Sághy T, Budai Z, Ujlaky-Nagy L, Bedekovics J, Beke L, Méhes G, Nagy G, Rühl R, Moise AR, Palczewski K, Szondy Z. PMID: 31766264; PMCID: PMC6920856.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 12 13; 294(50):19137-19154. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. PMID: 31694912; PMCID: PMC6916499.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Sci Rep. 2019 10 15; 9(1):14821. Kallestad L, Blackshaw S, Khalil AM, Palczewski K. PMID: 31616038; PMCID: PMC6794289.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    40. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 01 08; 28(1):293-303. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. PMID: 31611143; PMCID: PMC6952167.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    41. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Org Biomol Chem. 2019 09 21; 17(35):8125-8139. Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. PMID: 31455964; PMCID: PMC6739180.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    42. Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 2019 Sep 01; 10(9):4551-4567. Ruminski D, Palczewska G, Nowakowski M, Zielinska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. PMID: 31565509; PMCID: PMC6757456.
      View in: PubMed   Mentions: 6  
    43. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. J Biol Chem. 2019 09 27; 294(39):14215-14230. Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. PMID: 31399513; PMCID: PMC6768649.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    44. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 09 15; 416:100-108. Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. PMID: 31400484; PMCID: PMC6815255.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jul 16; 48(28):10581-10595. Kahremany S, Kubas A, Tochtrop GP, Palczewski K. PMID: 31218312; PMCID: PMC7004310.
      View in: PubMed   Mentions: 3     Fields:    
    46. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 08; 33(8):9526-9539. Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. PMID: 31121099; PMCID: PMC6662988.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    47. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17; 12(2). Mustafi D, Arbabi A, Ameri H, Palczewski K. PMID: 31108889; PMCID: PMC6631933.
      View in: PubMed   Mentions:
    48. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 06 14; 294(24):9461-9475. Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. PMID: 31073029; PMCID: PMC6579480.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 05 17; 294(20):8123-8133. Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. PMID: 30948514; PMCID: PMC6527158.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    50. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1442-1453. Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. PMID: 30947334; PMCID: PMC6736410.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    51. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1538-1546. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. PMID: 30994864; PMCID: PMC6736377.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    52. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 02; 5(2):eaav4322. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. PMID: 30820458; PMCID: PMC6392808.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    53. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 04 12; 294(15):6082-6093. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. PMID: 30770468; PMCID: PMC6463688.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    54. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 04; 33(4):5782-5792. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. PMID: 30645148; PMCID: PMC6436658.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    55. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019; 1834:311-332. Sakami S, Palczewski K. PMID: 30324452; PMCID: PMC6991117.
      View in: PubMed   Mentions:    Fields:    
    56. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019; 1834:333-343. Palczewska G, Kern TS, Palczewski K. PMID: 30324453; PMCID: PMC6991118.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    57. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 03; 33(3):3680-3692. Sakami S, Imanishi Y, Palczewski K. PMID: 30462532; PMCID: PMC6404573.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 01 09; 39(2):212-223. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. PMID: 30459230; PMCID: PMC6325258.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    59. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 10 22; 475(20):3171-3188. Daruwalla A, Choi EH, Palczewski K, Kiser PD. PMID: 30352831; PMCID: PMC6440480.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    60. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 09 06; 3(17). Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. PMID: 30185665; PMCID: PMC6171813.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    61. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 10; 94(4):1132-1144. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. PMID: 30018116; PMCID: PMC6108575.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    62. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Aug 21; 9(31):6480-6489. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. PMID: 30310578; PMCID: PMC6115637.
      View in: PubMed   Mentions: 13  
    63. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. PMID: 29659842; PMCID: PMC6005012.
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    417. Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry. 2002 Jan 08; 41(1):251-7. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K. PMID: 11772023; PMCID: PMC1363675.
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    418. Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti. ScientificWorldJournal. 2002; 2:106-107. Palczewski K. PMID: 29973825; PMCID: PMC6009445.
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    420. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002; 514:303-17. Haeseleer F, Palczewski K. PMID: 12596929.
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    421. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. PMID: 11860507; PMCID: PMC1363676.
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    422. Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3294-300. Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. PMID: 11726636; PMCID: PMC1436034.
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    423. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem. 2001 Dec 21; 276(51):48483-93. McBee JK, Van Hooser JP, Jang GF, Palczewski K. PMID: 11604395; PMCID: PMC1409735.
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    424. G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel. 2001 Sep; 4(5):561-74. Ballesteros J, Palczewski K. PMID: 12825452; PMCID: PMC1383658.
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    425. Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem. 2001 Nov 16; 276(46):43361-73. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K. PMID: 11524415; PMCID: PMC1363678.
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    426. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9948-53. Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. PMID: 11493703; PMCID: PMC55558.
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    427. Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol. 2001 Aug; 11(4):420-6. Okada T, Palczewski K. PMID: 11495733.
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    428. Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem. 2001 Aug; 382(8):1179-88. Li N, Sokal I, Bronson JD, Palczewski K, Baehr W. PMID: 11592399.
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    429. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 03; 40(26):7761-72. Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. PMID: 11425302; PMCID: PMC1698954.
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    430. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res. 2001 Jul; 20(4):469-529. McBee JK, Palczewski K, Baehr W, Pepperberg DR. PMID: 11390257.
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    431. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001 Aug 31; 276(35):32456-65. Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. PMID: 11418621; PMCID: PMC1361690.
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    432. Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci. 2001 May; 26(5):318-24. Okada T, Ernst OP, Palczewski K, Hofmann KP. PMID: 11343925.
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    433. Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem. 2001 Jul 13; 276(28):26148-53. Jang GF, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K. PMID: 11316815; PMCID: PMC1361691.
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    434. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22; 276(25):22287-95. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. PMID: 11292825; PMCID: PMC1364467.
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    435. Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 01; 72(2):193-202. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. PMID: 11401432.
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    436. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22; 171(1-2):111-7. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. PMID: 11165019.
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    437. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta. 2000 Dec 20; 1498(2-3):233-51. Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. PMID: 11108966.
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    438. Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 2000 Dec 12; 39(49):15225-33. Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. PMID: 11106502; PMCID: PMC1382172.
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    439. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 2000 Sep 19; 39(37):11370-80. McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. PMID: 10985782; PMCID: PMC1408314.
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    440. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J Biol Chem. 2000 Sep 08; 275(36):28128-38. Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. PMID: 10871622; PMCID: PMC1435698.
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    441. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci. 2000 Sep-Oct; 17(5):667-678. Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K. PMID: 11153648; PMCID: PMC1410813.
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    442. Crystal structure of rhodopsin: A G protein-coupled receptor. Science. 2000 Aug 04; 289(5480):739-45. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. PMID: 10926528.
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    443. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8623-8. Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. PMID: 10869443; PMCID: PMC26998.
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    444. Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 2000 Jun; 20(12):4275-87. Driessen CA, Winkens HJ, Hoffmann K, Kuhlmann LD, Janssen BP, Van Vugt AH, Van Hooser JP, Wieringa BE, Deutman AF, Palczewski K, Ruether K, Janssen JJ. PMID: 10825191; PMCID: PMC85795.
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    445. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5901-6. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M. PMID: 10811902; PMCID: PMC18531.
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    446. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol. 2000 May; 130(1):73-80. Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. PMID: 10806093.
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    447. Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays. 2000 Apr; 22(4):337-50. Palczewski K, Polans AS, Baehr W, Ames JB. PMID: 10723031.
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    448. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14; 275(2):1247-60. Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. PMID: 10625670; PMCID: PMC1364469.
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    449. Multienzyme analysis of visual cycle. Methods Enzymol. 2000; 316:330-44. Stecher H, Palczewski K. PMID: 10800685; PMCID: PMC1560099.
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    450. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol. 2000; 316:359-71. Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. PMID: 10800687; PMCID: PMC1552099.
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    451. Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000; 316:372-83. Haeseleer F, Palczewski K. PMID: 10800688.
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    452. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods Enzymol. 2000; 316:436-51. Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR, Palczewski K, Gelb MH. PMID: 10800693; PMCID: PMC1435690.
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    453. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. PMID: 10564809.
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    454. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12; 38(41):13542-50. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. PMID: 10521261.
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    455. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999 Sep 14; 38(37):12012-9. Palczewski K, Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC. PMID: 10508404.
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    456. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem. 1999 Jul 09; 274(28):19829-37. Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W,