Palczewski, Krzysztof

Title(s)Professor, Ophthalmology
Phone(949) 824-6527
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    Collapse Research 
    Collapse Research Activities and Funding
    Use of systems pharmacology to prevent rod and cone photoreceptor degeneration
    NIH/NEI R24EY027283Mar 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    A two-photon ophthalmoscope for human retinal imaging and functional testing
    NIH/NEI U01EY025451May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Carotenoids in Vision
    NIH/NEI R01EY020551Nov 1, 2009 - Mar 31, 2020
    Role: Co-Principal Investigator
    Visual Sciences Training Program
    NIH/NEI T32EY007157Sep 30, 2000 - May 31, 2022
    Role: Principal Investigator
    Retinoids in Vision
    NIH/NEI R01EY009339Jan 1, 1992 - Aug 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 Feb; 5(2):eaav4322. PMID: 30820458.
      View in: PubMed
    2. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 Feb 15. PMID: 30770468.
      View in: PubMed
    3. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 Jan 15; fj201802493R. PMID: 30645148.
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    4. Sakami S, Palczewski K. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019; 1834:311-332. PMID: 30324452.
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    5. Palczewska G, Kern TS, Palczewski K. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019; 1834:333-343. PMID: 30324453.
      View in: PubMed
    6. Sakami S, Imanishi Y, Palczewski K. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2018 Nov 21; fj201801662R. PMID: 30462532.
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    7. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 Jan 09; 39(2):212-223. PMID: 30459230.
      View in: PubMed
    8. Daruwalla A, Choi EH, Palczewski K, Kiser PD. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 Oct 22; 475(20):3171-3188. PMID: 30352831.
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    9. Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 Sep 06; 3(17). PMID: 30185665.
      View in: PubMed
    10. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 Oct; 94(4):1132-1144. PMID: 30018116.
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    11. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Aug 21; 9(31):6480-6489. PMID: 30310578.
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    12. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. PMID: 29659842.
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    13. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. PMID: 29777099.
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    14. Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 05 17; 9(1):1976. PMID: 29773803.
      View in: PubMed
    15. Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29; 4:1-19. PMID: 30240733.
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    16. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 Apr 02; 150(4):571-590. PMID: 29500274.
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    17. Luu J, Palczewski K. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):2866-2872. PMID: 29483257.
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    18. Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 05; 93(5):438-452. PMID: 29453250.
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    19. Owen TS, Salom D, Sun W, Palczewski K. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 02 13; 57(6):1022-1030. PMID: 29320632.
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    20. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 06; 32(6):3289-3300. PMID: 29401616.
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    21. Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018; 14(7):688-694. PMID: 29651942.
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    22. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 Feb; 364(2):207-220. PMID: 29162627.
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    23. Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 07; 7(1):14623. PMID: 29116131.
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    24. Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Nov 01; 8(11):5228-5242. PMID: 29188116.
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    25. Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9675-E9684. PMID: 29078372.
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    26. Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 12 01; 292(48):19826-19839. PMID: 28978645.
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    27. Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. Designing Safer Analgesics via µ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 11; 38(11):1016-1037. PMID: 28935293.
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    28. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 09; 6(5):6. PMID: 28920007.
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    29. Alexander NS, Palczewski K. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov; 26(11):2118-2125. PMID: 28762619.
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    30. Tonade D, Liu H, Palczewski K, Kern TS. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 10; 60(10):2111-2120. PMID: 28755268.
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    31. Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 05 24; 7(1):2390. PMID: 28539612.
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    32. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. PMID: 28493664.
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    33. Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 06 30; 292(26):10983-10997. PMID: 28487362.
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    34. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 Jul; 362(1):131-145. PMID: 28476927.
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    35. Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 05 02; 56(17):2338-2348. PMID: 28402104.
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    36. Palczewski K. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct; 124:167-168. PMID: 28363722.
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    37. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. PMID: 28289214.
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    38. Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar; 10069. PMID: 28989217.
      View in: PubMed
    39. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16; 7:42-52. PMID: 28624218.
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    40. Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 02 24; 292(8):3366-3378. PMID: 28104803.
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    41. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 01 15; 26(2):305-319. PMID: 28065882.
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    42. Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):604-613. PMID: 28129424.
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    43. Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10; 56(1):61-72. PMID: 28045251.
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    44. Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29; 55(47):6545-6557. PMID: 27809489.
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    45. Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Dec 01; 7(12):5148-5169. PMID: 28018732.
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    46. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23; 291(52):26937-26949. PMID: 27875314.
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    47. Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 01; 115:1-13. PMID: 27838510.
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    48. Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 10 15; 25(20):4376-4388. PMID: 28172828.
      View in: PubMed
    49. Chen Y, Kern TS, Kiser PD, Palczewski K. Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. PMID: 27720767.
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    50. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 01; 44(21):10467-10479. PMID: 27655633.
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    51. Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4272-81. PMID: 27548901; PMCID: PMC5015983.
    52. Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 08 22; 55(35):10331-5. PMID: 27460867.
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    53. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. PMID: 27460988.
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    54. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 09 09; 291(37):19401-12. PMID: 27453555; PMCID: PMC5016679 [Available on 09/09/17].
    55. Kiser PD, Palczewski K. Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 10; 2:197-234. PMID: 27917399.
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    56. Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jul 01; 7(7):2671-91. PMID: 27446697; PMCID: PMC4948621.
    57. Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 07 18; 55(30):8661-5. PMID: 27244650.
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    58. Sears AE, Palczewski K. Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 07; 55(22):3082-91. PMID: 27183166.
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    59. Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. Dominant and recessive mutations in rhodopsin activate different cell death pathways. Hum Mol Genet. 2016 07 01; 25(13):2801-2812. PMID: 27149983.
      View in: PubMed
    60. Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 06; 12(6):444-51. PMID: 27110679; PMCID: PMC4871731 [Available on 10/25/16].
    61. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17; 291(25):12951-9. PMID: 27129240; PMCID: PMC4933214 [Available on 06/17/17].
    62. Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15; 499:63-65. PMID: 26851339; PMCID: PMC4788517 [Available on 04/15/17].
    63. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15; 11(4):1049-57. PMID: 26811964; PMCID: PMC4841470 [Available on 04/15/17].
    64. Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):632-46. PMID: 26903224; PMCID: PMC4771181.
    65. Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):647-57. PMID: 26903225; PMCID: PMC4771186.
    66. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18; 290(51):30212-23. PMID: 26499794; PMCID: PMC4683246 [Available on 12/18/16].
    67. Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15; 593(22):4923-41. PMID: 26350353; PMCID: PMC4650407 [Available on 11/15/16].
    68. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27; 290(48):29035-44. PMID: 26468292.
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    69. Sundermeier TR, Palczewski K. The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016 Jan; 30(1):23-33. PMID: 26399786; PMCID: PMC4684546 [Available on 01/01/17].
    70. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 06; 290(45):27239-47. PMID: 26391396; PMCID: PMC4646373 [Available on 11/06/16].
    71. Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16; 290(42):25728-44. PMID: 26330551; PMCID: PMC4646215 [Available on 10/16/16].
    72. Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomed Opt Express. 2015 Sep 01; 6(9):3352-61. PMID: 26417507; PMCID: PMC4574663.
    73. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. Macromol Biosci. 2015 Dec; 15(12):1663-72. PMID: 26271011; PMCID: PMC4770799 [Available on 12/01/16].
    74. Alexander NS, Palczewska G, Palczewski K. Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Aug 01; 6(8):3032-52. PMID: 26309765; PMCID: PMC4541529.
    75. Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. Serum levels of lipid metabolites in age-related macular degeneration. FASEB J. 2015 Nov; 29(11):4579-88. PMID: 26187344; PMCID: PMC4608905 [Available on 11/01/16].
    76. Hofmann L, Palczewski K. Advances in understanding the molecular basis of the first steps in color vision. Prog Retin Eye Res. 2015 Nov; 49:46-66. PMID: 26187035; PMCID: PMC4651776.
    77. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28; 290(35):21568-79. PMID: 26139608; PMCID: PMC4571881.
    78. Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4936-42. PMID: 26225634; PMCID: PMC4525634.
    79. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 01; 125(7):2781-94. PMID: 26075817; PMCID: PMC4563688.
    80. Yuan S, Palczewski K, Peng Q, Kolinski M, Vogel H, Filipek S. The mechanism of ligand-induced activation or inhibition of µ- and ?-opioid receptors. Angew Chem Int Ed Engl. 2015 Jun 22; 54(26):7560-3. PMID: 25968837.
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    81. Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opin Orphan Drugs. 2015 May 04; 3(5):563-575. PMID: 26246977.
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    82. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun; 11(6):409-15. PMID: 25894083; PMCID: PMC4433804.
    83. Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2553-67. PMID: 25783607; PMCID: PMC4554260.
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    183. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29; 286(17):15543-55. PMID: 21383019; PMCID: PMC3083179.
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    188. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem. 2011 Feb 18; 286(7):5607-13. PMID: 21159775; PMCID: PMC3037674.
    189. Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar; 25(3):948-59. PMID: 21106934; PMCID: PMC3042841.
    190. Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med. 2010 Dec; 16(12):1444-9. PMID: 21076393; PMCID: PMC3057900.
    191. Palczewski K. Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov; 128(11):1483-5. PMID: 21060052; PMCID: PMC4495581.
    192. Lodowski DT, Palczewski K, Miyagi M. Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 2010 Nov 09; 49(44):9425-7. PMID: 20939497; PMCID: PMC3075965.
    193. Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb; 84(2):336-41. PMID: 20881313; PMCID: PMC3071267.
    194. Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec; 20(12):1643-53. PMID: 20826825.
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    197. Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20; 401(3):363-73. PMID: 20600113; PMCID: PMC2917047.
    198. Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 03; 285(36):27891-9. PMID: 20573961.
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    200. Palczewski K. Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun; 31(6):284-95. PMID: 20435355; PMCID: PMC2882531.
    201. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15; 26(14):1804-5. PMID: 20501551; PMCID: PMC2894509.
    202. Jastrzebska B, Tsybovsky Y, Palczewski K. Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28; 428(1):1-10. PMID: 20423327; PMCID: PMC2875673.
    203. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8428-33. PMID: 20404157; PMCID: PMC2889565.
    204. Kiser PD, Palczewski K. Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep; 29(5):428-42. PMID: 20304090; PMCID: PMC2903629.
    205. von Lintig J, Kiser PD, Golczak M, Palczewski K. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul; 35(7):400-10. PMID: 20188572; PMCID: PMC2891588.
    206. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One. 2010 Feb 19; 5(2):e9312. PMID: 20174477; PMCID: PMC2824852.
    207. Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 09; 49(5):827-34. PMID: 20047303; PMCID: PMC2819031.
    208. Kevany BM, Palczewski K. Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb; 25(1):8-15. PMID: 20134024; PMCID: PMC2839896.
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    211. Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun; 24(6):1656-66. PMID: 20061533.
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    214. Tsybovsky Y, Molday RS, Palczewski K. The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010; 703:105-25. PMID: 20711710; PMCID: PMC2930353.
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    222. Maeda A, Shiose S, Okano K, Matosky M, Maeda T, Palczewski K. WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration. Invest Ophthalmol Vis Sci. 2009 Aug 13. PMID: 19458342.
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    234. Lodowski DT, Palczewski K. Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS. 2009 Mar; 4(2):88-95. PMID: 19339946; PMCID: PMC2771364.
    235. Lodowski DT, Angel TE, Palczewski K. Comparative analysis of GPCR crystal structures. Photochem Photobiol. 2009 Mar-Apr; 85(2):425-30. PMID: 19192200; PMCID: PMC2681091.
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    237. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 Dec 16; 47(50):13296-307. PMID: 19053287.
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    240. Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem. 2009 Jan 23; 284(4):2472-81. PMID: 19008222.
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    249. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16; 283(20):13510-9. PMID: 18348983; PMCID: PMC2376245.
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    261. Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007 Nov; 15(11):1392-402. PMID: 17997965; PMCID: PMC2556213.
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