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Krzysztof Palczewski

Title(s)Professor, Ophthalmology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6527
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    Collapse Research 
    Collapse Research Activities and Funding
    Opsin signaling in mammalian rod photoreceptors
    NIH/NEI R01EY030912Jun 1, 2020 - Apr 30, 2024
    Role: Co-Principal Investigator
    Use of systems pharmacology to prevent rod and cone photoreceptor degeneration
    NIH/NEI R24EY027283Jul 1, 2017 - Mar 31, 2022
    Role: Principal Investigator
    Visual Sciences Training Program
    NIH/NEI T32EY007157Jun 1, 2017 - Sep 30, 2005
    Role: Principal Investigator
    A two-photon ophthalmoscope for human retinal imaging and functional testing
    NIH/NEI U01EY025451May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Carotenoids in Vision
    NIH/NEI R01EY020551Aug 1, 2011 - Mar 31, 2020
    Role: Co-Principal Investigator
    Retinoids in Vision
    NIH/NEI R01EY009339Aug 1, 1992 - Jul 31, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 Aug 28. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. PMID: 32860273.
      View in: PubMed   Mentions:    Fields:    
    2. Noninvasive two-photon optical biopsy of retinal fluorophores. Proc Natl Acad Sci U S A. 2020 Aug 26. Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K. PMID: 32848058.
      View in: PubMed   Mentions:    Fields:    
    3. Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020 Aug 05. Palczewski K, Kiser PD. PMID: 32759209.
      View in: PubMed   Mentions:    Fields:    
    4. Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Hum Mol Genet. 2020 Jul 21. Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K. PMID: 32691052.
      View in: PubMed   Mentions:    Fields:    
    5. Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorg Med Chem Lett. 2020 Jul 18; 30(18):127421. Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. PMID: 32717613.
      View in: PubMed   Mentions:    Fields:    
    6. Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity. Transl Vis Sci Technol. 2020 Jul; 9(8):7. Labuz G, Rayamajhi A, Usinger J, Komar K, Merz P, Khoramnia R, Palczewska G, Palczewski K, Auffarth GU. PMID: 32855854.
      View in: PubMed   Mentions:
    7. PAR4 activation involves extracellular loop-3 and transmembrane residue Thr153. Blood. 2020 Jun 23. Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K, Invent Consortium I, Nieman MT. PMID: 32575122.
      View in: PubMed   Mentions: 2     Fields:    
    8. Retinoids in the visual cycle: Role of the retinal G protein-coupled receptor. J Lipid Res. 2020 Jun 03. Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. PMID: 32493732.
      View in: PubMed   Mentions: 1     Fields:    
    9. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9922-9931. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, Liu Q, Boldt K, Wolfrum U, Ueffing M, Garanto A, Roepman R, Collin RWJ. PMID: 32312818.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PLoS One. 2020; 15(4):e0228121. Valdez-Lopez JC, Gulati S, Ortiz EA, Palczewski K, Robinson PR. PMID: 32236094.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules. 2019 11 13; 9(11). Sarang Z, Sághy T, Budai Z, Ujlaky-Nagy L, Bedekovics J, Beke L, Méhes G, Nagy G, Rühl R, Moise AR, Palczewski K, Szondy Z. PMID: 31766264.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 12 13; 294(50):19137-19154. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. PMID: 31694912.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Sci Rep. 2019 10 15; 9(1):14821. Kallestad L, Blackshaw S, Khalil AM, Palczewski K. PMID: 31616038.
      View in: PubMed   Mentions: 1     Fields:    
    14. Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 01 08; 28(1):293-303. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. PMID: 31611143.
      View in: PubMed   Mentions:    Fields:    
    15. Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Org Biomol Chem. 2019 09 21; 17(35):8125-8139. Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. PMID: 31455964.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 2019 Sep 01; 10(9):4551-4567. Ruminski D, Palczewska G, Nowakowski M, Zielinska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. PMID: 31565509.
      View in: PubMed   Mentions:
    17. Cryo-EM structure of the native rhodopsin dimer in nanodiscs. J Biol Chem. 2019 09 27; 294(39):14215-14230. Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. PMID: 31399513.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 09 15; 416:100-108. Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. PMID: 31400484.
      View in: PubMed   Mentions: 1     Fields:    
    19. Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jul 16; 48(28):10581-10595. Kahremany S, Kubas A, Tochtrop GP, Palczewski K. PMID: 31218312.
      View in: PubMed   Mentions:    Fields:    
    20. Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 08; 33(8):9526-9539. Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. PMID: 31121099.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17; 12(2). Mustafi D, Arbabi A, Ameri H, Palczewski K. PMID: 31108889.
      View in: PubMed   Mentions:
    22. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 06 14; 294(24):9461-9475. Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. PMID: 31073029.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 05 17; 294(20):8123-8133. Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. PMID: 30948514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    24. A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1442-1453. Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. PMID: 30947334.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    25. Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1538-1546. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. PMID: 30994864.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    26. Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 02; 5(2):eaav4322. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. PMID: 30820458.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 04 12; 294(15):6082-6093. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. PMID: 30770468.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 04; 33(4):5782-5792. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. PMID: 30645148.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019; 1834:311-332. Sakami S, Palczewski K. PMID: 30324452.
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    30. Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019; 1834:333-343. Palczewska G, Kern TS, Palczewski K. PMID: 30324453.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 03; 33(3):3680-3692. Sakami S, Imanishi Y, Palczewski K. PMID: 30462532.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 01 09; 39(2):212-223. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. PMID: 30459230.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 10 22; 475(20):3171-3188. Daruwalla A, Choi EH, Palczewski K, Kiser PD. PMID: 30352831.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    34. Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 09 06; 3(17). Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. PMID: 30185665.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    35. Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 10; 94(4):1132-1144. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. PMID: 30018116.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    36. Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Aug 21; 9(31):6480-6489. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. PMID: 30310578.
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    37. Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. PMID: 29659842.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. PMID: 29777099.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 05 17; 9(1):1976. Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. PMID: 29773803.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    40. A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29; 4:1-19. Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. PMID: 30240733.
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    41. Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 04 02; 150(4):571-590. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. PMID: 29500274.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):2866-2872. Luu J, Palczewski K. PMID: 29483257.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 05; 93(5):438-452. Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. PMID: 29453250.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 02 13; 57(6):1022-1030. Owen TS, Salom D, Sun W, Palczewski K. PMID: 29320632.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    45. New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 06; 32(6):3289-3300. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. PMID: 29401616.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018; 14(7):688-694. Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. PMID: 29651942.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    47. A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 02; 364(2):207-220. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. PMID: 29162627.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    48. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 11 07; 7(1):14623. Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. PMID: 29116131.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    49. Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Nov 01; 8(11):5228-5242. Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. PMID: 29188116.
      View in: PubMed   Mentions:
    50. Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9675-E9684. Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. PMID: 29078372.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    51. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 12 01; 292(48):19826-19839. Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. PMID: 28978645.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    52. Designing Safer Analgesics via µ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 11; 38(11):1016-1037. Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. PMID: 28935293.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    53. Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 09; 6(5):6. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. PMID: 28920007.
      View in: PubMed   Mentions:
    54. Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov; 26(11):2118-2125. Alexander NS, Palczewski K. PMID: 28762619.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    55. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 10; 60(10):2111-2120. Tonade D, Liu H, Palczewski K, Kern TS. PMID: 28755268.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 05 24; 7(1):2390. Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. PMID: 28539612.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    57. Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. PMID: 28493664.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    58. Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 06 30; 292(26):10983-10997. Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. PMID: 28487362.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    59. Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 07; 362(1):131-145. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. PMID: 28476927.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    60. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 05 02; 56(17):2338-2348. Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. PMID: 28402104.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    61. Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct; 124:167-168. Palczewski K. PMID: 28363722.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    62. Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. PMID: 28289214.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    63. Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar; 10069. Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. PMID: 28989217.
      View in: PubMed   Mentions:
    64. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16; 7:42-52. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. PMID: 28624218.
      View in: PubMed   Mentions:
    65. MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 02 24; 292(8):3366-3378. Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. PMID: 28104803.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    66. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 01 15; 26(2):305-319. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. PMID: 28065882.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    67. Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):604-613. Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. PMID: 28129424.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    68. A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10; 56(1):61-72. Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. PMID: 28045251.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
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    380. Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochim Biophys Acta. 2002 Oct 11; 1565(2):168-82. Stenkamp RE, Filipek S, Driessen CA, Teller DC, Palczewski K. PMID: 12409193.
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    381. Crystal structure of rhodopsin: a G-protein-coupled receptor. Chembiochem. 2002 Oct 04; 3(10):963-7. Stenkamp RE, Teller DC, Palczewski K. PMID: 12362360.
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    382. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J Biol Chem. 2002 Nov 22; 277(47):45537-45546. Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K. PMID: 12226107.
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    383. Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. J Biol Chem. 2002 Nov 01; 277(44):42315-42324. Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Preston Van Hooser J, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K. PMID: 12176994.
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    384. Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol. 2002 Aug; 32(8):2300-7. Maeda A, Maeda T, Ohguro H, Palczewski K, Sato N. PMID: 12209643.
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    385. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7711-6. Yang J, McBride S, Mak DO, Vardi N, Palczewski K, Haeseleer F, Foskett JK. PMID: 12032348.
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    386. G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol. 2003; 65:851-79. Filipek S, Stenkamp RE, Teller DC, Palczewski K. PMID: 12471166.
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    387. GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J. 2002 Apr 02; 21(7):1545-54. Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. PMID: 11927539.
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    388. Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem. 2002 May 24; 277(21):19173-82. Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. PMID: 11897783.
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    389. Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci. 2002 Mar; 5(3):210-7. Lee A, Westenbroek RE, Haeseleer F, Palczewski K, Scheuer T, Catterall WA. PMID: 11865310.
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    390. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun. 2002 Jan 18; 290(2):615-23. Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. PMID: 11785943.
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    391. Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry. 2002 Jan 08; 41(1):251-7. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K. PMID: 11772023.
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    392. Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti. ScientificWorldJournal. 2002; 2:106-107. Palczewski K. PMID: 29973825.
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    393. Rhodopsin and its kinase. Methods Enzymol. 2002; 343:578-600. Sokal I, Pulvermüller A, Buczylko J, Hofmann KP, Palczewski K. PMID: 11665593.
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    394. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002; 514:303-17. Haeseleer F, Palczewski K. PMID: 12596929.
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    395. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. PMID: 11860507.
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    396. Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3294-300. Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. PMID: 11726636.
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    397. Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem. 2001 Dec 21; 276(51):48483-93. McBee JK, Van Hooser JP, Jang GF, Palczewski K. PMID: 11604395.
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    398. G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel. 2001 Sep; 4(5):561-74. Ballesteros J, Palczewski K. PMID: 12825452.
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    399. Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem. 2001 Nov 16; 276(46):43361-73. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K. PMID: 11524415.
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    400. Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9948-53. Mendez A, Burns ME, Sokal I, Dizhoor AM, Baehr W, Palczewski K, Baylor DA, Chen J. PMID: 11493703.
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    401. Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol. 2001 Aug; 11(4):420-6. Okada T, Palczewski K. PMID: 11495733.
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    402. Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem. 2001 Aug; 382(8):1179-88. Li N, Sokal I, Bronson JD, Palczewski K, Baehr W. PMID: 11592399.
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    403. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 03; 40(26):7761-72. Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. PMID: 11425302.
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    404. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res. 2001 Jul; 20(4):469-529. McBee JK, Palczewski K, Baehr W, Pepperberg DR. PMID: 11390257.
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    405. Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001 Aug 31; 276(35):32456-65. Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. PMID: 11418621.
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    406. Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci. 2001 May; 26(5):318-24. Okada T, Ernst OP, Palczewski K, Hofmann KP. PMID: 11343925.
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    407. Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem. 2001 Jul 13; 276(28):26148-53. Jang GF, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K. PMID: 11316815.
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    408. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22; 276(25):22287-95. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. PMID: 11292825.
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    409. Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 01; 72(2):193-202. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. PMID: 11401432.
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    410. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22; 171(1-2):111-7. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. PMID: 11165019.
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    411. Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta. 2000 Dec 20; 1498(2-3):233-51. Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. PMID: 11108966.
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    412. Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 2000 Dec 12; 39(49):15225-33. Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. PMID: 11106502.
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    413. Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 2000 Sep 19; 39(37):11370-80. McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. PMID: 10985782.
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    414. Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J Biol Chem. 2000 Sep 08; 275(36):28128-38. Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. PMID: 10871622.
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    415. Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci. 2000 Sep-Oct; 17(5):667-678. Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K. PMID: 11153648.
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    416. Crystal structure of rhodopsin: A G protein-coupled receptor. Science. 2000 Aug 04; 289(5480):739-45. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. PMID: 10926528.
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    417. Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8623-8. Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. PMID: 10869443.
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    418. Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 2000 Jun; 20(12):4275-87. Driessen CA, Winkens HJ, Hoffmann K, Kuhlmann LD, Janssen BP, Van Vugt AH, Van Hooser JP, Wieringa BE, Deutman AF, Palczewski K, Ruether K, Janssen JJ. PMID: 10825191.
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    419. The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5901-6. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M. PMID: 10811902.
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    420. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol. 2000 May; 130(1):73-80. Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. PMID: 10806093.
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    421. Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays. 2000 Apr; 22(4):337-50. Palczewski K, Polans AS, Baehr W, Ames JB. PMID: 10723031.
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    422. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14; 275(2):1247-60. Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. PMID: 10625670.
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    423. Multienzyme analysis of visual cycle. Methods Enzymol. 2000; 316:330-44. Stecher H, Palczewski K. PMID: 10800685.
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    424. Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol. 2000; 316:359-71. Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. PMID: 10800687.
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    425. Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000; 316:372-83. Haeseleer F, Palczewski K. PMID: 10800688.
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    426. Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods Enzymol. 2000; 316:436-51. Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR, Palczewski K, Gelb MH. PMID: 10800693.
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    427. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. PMID: 10564809.
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    428. Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12; 38(41):13542-50. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. PMID: 10521261.
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    429. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999 Sep 14; 38(37):12012-9. Palczewski K, Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC. PMID: 10508404.
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    430. Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem. 1999 Jul 09; 274(28):19829-37. Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K. PMID: 10391927.
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    431. A novel form of rhodopsin kinase from chicken retina and pineal gland. FEBS Lett. 1999 Jul 02; 454(1-2):115-21. Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. PMID: 10413107.
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    432. Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem. 1999 Jul 02; 274(27):19329-37. Ames JB, Dizhoor AM, Ikura M, Palczewski K, Stryer L. PMID: 10383444.
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    433. beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem. 1999 May 07; 274(19):12984-9. Mukherjee S, Palczewski K, Gurevich VV, Hunzicker-Dunn M. PMID: 10224047.
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    434. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. J Biol Chem. 1999 Mar 26; 274(13):8577-85. Stecher H, Gelb MH, Saari JC, Palczewski K. PMID: 10085092.
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    435. Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem. 1999 Mar 05; 274(10):6526-35. Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K. PMID: 10037746.
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    436. Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry. 1999 Mar 02; 38(9):2611-6. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP. PMID: 10052930.
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    437. Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1. Biochemistry. 1999 Feb 02; 38(5):1387-93. Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K. PMID: 9931003.
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    438. A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):493-8. Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. PMID: 9892661.
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    439. Molecular mechanism of visual transduction. Novartis Found Symp. 1999; 224:191-204; discussion 204-7. Palczewski K, Verlinde CL, Haeseleer F. PMID: 10614052.
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    440. Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by alpha-toxin. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15014-9. Otto-Bruc AE, Fariss RN, Van Hooser JP, Palczewski K. PMID: 9844007.
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    441. Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol. 1998 Dec; 68(6):824-8. Ohguro H, Yoshida N, Shindou H, Crabb JW, Palczewski K, Tsuda M. PMID: 9867032.
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    442. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21; 273(34):21790-9. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. PMID: 9705317.
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    443. GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell. 1998 Jul; 2(1):129-33. Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K. PMID: 9702199.
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    445. Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci. 1998 May 01; 18(9):3195-205. Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV. PMID: 9547228.
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    446. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5351-6. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. PMID: 9560279.
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    447. Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem. 1998 Mar 15; 252(3):591-9. Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K, Baehr W. PMID: 9546678.
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    448. Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem. 1998 Feb 27; 273(9):5124-31. Zhao X, Huang J, Khani SC, Palczewski K. PMID: 9478965.
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    449. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1271-6. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. PMID: 9448321.
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    451. Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A. 1998 Jan 06; 95(1):328-33. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. PMID: 9419375.
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    452. Calcium binding to recoverin: implications for secondary structure and membrane association. Biochim Biophys Acta. 1997 Oct 17; 1342(2):164-74. Johnson WC, Palczewski K, Gorczyca WA, Riazance-Lawrence JH, Witkowska D, Polans AS. PMID: 9392525.
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