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Piomelli, Daniele

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentAnatomy and Neurobiology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9179, 7080
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    Collapse Research 
    Collapse Research Activities and Funding
    ICAL: Impact of Cannabinoids Across Lifespan
    NIH/NIDA P50DA044118Jul 1, 2018 - May 31, 2022
    Role: Principal Investigator
    Peripheral FAAH as a target for novel analgesics
    NIH/NIDA R42DA033683Mar 15, 2017 - Feb 28, 2019
    Role: Principal Investigator
    A Protective role for 2-AG in age-dependent cognitive impairment.
    NIH/NIA R21AG052336Aug 15, 2016 - May 31, 2018
    Role: Principal Investigator
    Lipidomics analysis of identified single neurons in the adult rodent brain
    NIH/NIDA R21DA041776Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    A new treatment for NSAID-associated gastrointestinal damage
    NIH/NIDDK R41DK104489Jul 1, 2015 - Dec 31, 2015
    Role: Principal Investigator
    Optimization and preclinical development of FAAH inhibitors for smoking cessation
    NIH/NIDA DP1DA031387Sep 30, 2010 - Jul 31, 2015
    Role: Principal Investigator
    Lipid biosignatures of drug addiction
    NIH/NIDA RC2DA028902Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Role of endocannabinoid signaling in stress-coping behavior
    NIH/NIAAA RL1AA017538Sep 30, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Role of oleoylethanolamide in the control of food intake
    NIH/NIDDK R01DK073955Apr 1, 2007 - Jun 30, 2011
    Role: Principal Investigator
    Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    NIH/NIDA R21DA022702Sep 30, 2006 - Jul 31, 2010
    Role: Principal Investigator
    Oleylethanolamide derivatives as anti-obesity agents
    NIH/NIDDK R41DK070347Sep 20, 2005 - Aug 31, 2006
    Role: Principal Investigator
    THE NEUROBIOLOGY OF SUBSTANCE ABUSE
    NIH/NIDA T32DA007318Sep 1, 2001 - Jun 30, 2008
    Role: Principal Investigator
    CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    NIH/NIDA R01DA012653Aug 1, 1999 - May 31, 2005
    Role: Principal Investigator
    Characterization of Anandamide Transport in Brain
    NIH/NIDA R01DA012413Aug 14, 1998 - Jun 30, 2017
    Role: Principal Investigator
    Characterization of a novel brain cannabinoid ligand
    NIH/NIDA R01DA012447Aug 14, 1998 - Jul 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Danandeh A, Vozella V, Lim J, Oveisi F, Ramirez GL, Mears D, Wynn G, Piomelli D. Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety. Psychopharmacology (Berl). 2018 Sep 24. PMID: 30251159.
      View in: PubMed
    2. Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, Durante M, Sgambellone S, Masini E, Rivara S. Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the rabbit. J Med Chem. 2018 Aug 20. PMID: 30126274.
      View in: PubMed
    3. Heinitz S, Basolo A, Piomelli D, Krakoff J, Piaggi P. Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure. J Clin Endocrinol Metab. 2018 Aug 02. PMID: 30113648.
      View in: PubMed
    4. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. Author Correction: Patch clamp-assisted single neuron lipidomics. Sci Rep. 2018 Apr 25; 8(1):6772. PMID: 29691427.
      View in: PubMed
    5. Piomelli D, Weiss S, Boyd G, Pacula RL, Cooper Z. Cannabis and the Opioid Crisis. Cannabis Cannabinoid Res. 2018; 3(1):108-116. PMID: 29789812.
      View in: PubMed
    6. Koethe D, Pahlisch F, Hellmich M, Rohleder C, Mueller JK, Meyer-Lindenberg A, Torrey EF, Piomelli D, Leweke FM. Familial abnormalities of endocannabinoid signaling in schizophrenia. World J Biol Psychiatry. 2018 Mar 22; 1-9. PMID: 29521179.
      View in: PubMed
    7. Greco R, Demartini C, Zanaboni AM, Piomelli D, Tassorelli C. Endocannabinoid System and Migraine Pain: An Update. Front Neurosci. 2018; 12:172. PMID: 29615860.
      View in: PubMed
    8. Heinitz S, Basolo A, Piaggi P, Piomelli D, Jumpertz von Schwartzenberg R, Krakoff J. Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage. J Clin Endocrinol Metab. 2018 Mar 01; 103(3):1077-1087. PMID: 29300902.
      View in: PubMed
    9. Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ. Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem. 2018 Mar 02; 293(9):3028-3038. PMID: 29326169.
      View in: PubMed
    10. Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S, Mor M, Piomelli D. Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem Commun (Camb). 2017 Nov 28; 53(95):12814-12817. PMID: 29143042.
      View in: PubMed
    11. Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G. Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. Mol Psychiatry. 2017 Nov 14. PMID: 29133950.
      View in: PubMed
    12. Sasso O, Summa M, Armirotti A, Pontis S, De Mei C, Piomelli D. The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis. J Invest Dermatol. 2018 Mar; 138(3):562-569. PMID: 29054595.
      View in: PubMed
    13. Schoch H, Huerta MY, Ruiz CM, Farrell MR, Jung KM, Huang JJ, Campbell RR, Piomelli D, Mahler SV. Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats. Psychopharmacology (Berl). 2018 Jan; 235(1):121-134. PMID: 29022083.
      View in: PubMed
    14. Rock EM, Moreno-Sanz G, Limebeer CL, Petrie GN, Angelini R, Piomelli D, Parker LA. Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARa and CB1 receptors. Br J Pharmacol. 2017 Nov; 174(21):3837-3847. PMID: 28805944.
      View in: PubMed
    15. Kazan K, Piomelli D, Rohrabacher D, Ajax L. Expert Panel on Understanding Cannabis: Medicine, Society, Government. Cannabis Cannabinoid Res. 2017; 2(1):247-251. PMID: 29082321.
      View in: PubMed
    16. Vozella V, Basit A, Misto A, Piomelli D. Age-dependent changes in nervonic acid-containing sphingolipids in mouse hippocampus. Biochim Biophys Acta. 2017 12; 1862(12):1502-1511. PMID: 28855145.
      View in: PubMed
    17. Petracca R, Romeo E, Baggelaar MP, Artola M, Pontis S, Ponzano S, Overkleeft HS, van der Stelt M, Piomelli D. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb). 2017 Aug 22; 53(86):11810-11813. PMID: 29035406.
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    18. Greco R, Demartini C, Zanaboni AM, Berliocchi L, Piomelli D, Tassorelli C. Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine? Cephalalgia. 2018 May; 38(6):1138-1147. PMID: 28816506.
      View in: PubMed
    19. Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D. Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Sci Rep. 2017 Aug 07; 7(1):7411. PMID: 28785021.
      View in: PubMed
    20. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. Patch clamp-assisted single neuron lipidomics. Sci Rep. 2017 Jul 13; 7(1):5318. PMID: 28706218.
      View in: PubMed
    21. Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex. Mol Psychiatry. 2018 Apr; 23(4):1040-1050. PMID: 28630452.
      View in: PubMed
    22. Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R. Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage. Int J Obes (Lond). 2017 Oct; 41(10):1585-1593. PMID: 28607453.
      View in: PubMed
    23. Angelini R, Argueta DA, Piomelli D, DiPatrizio NV. Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware. Cannabis Cannabinoid Res. 2017; 2(1):123-132. PMID: 28861512.
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    24. Piomelli D, Cooper Z, Abrams D, Grant I, Patel S. A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members. Cannabis Cannabinoid Res. 2017; 2(1):155-159. PMID: 28861515.
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    25. Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends Neurosci. 2017 07; 40(7):385-396. PMID: 28554687.
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    26. Khurana L, Mackie K, Piomelli D, Kendall DA. Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities. Neuropharmacology. 2017 Sep 15; 124:3-12. PMID: 28527758.
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    27. Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cereb Cortex. 2017 May 17; 1-14. PMID: 28520937.
      View in: PubMed
    28. Marrone MC, Morabito A, Giustizieri M, Chiurchiù V, Leuti A, Mattioli M, Marinelli S, Riganti L, Lombardi M, Murana E, Totaro A, Piomelli D, Ragozzino D, Oddi S, Maccarrone M, Verderio C, Marinelli S. TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nat Commun. 2017 May 10; 8:15292. PMID: 28489079.
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    29. den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT. Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels. J Alzheimers Dis. 2017; 60(3):769-781. PMID: 28035926.
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    30. Igarashi M, Narayanaswami V, Kimonis V, Galassetti PM, Oveisi F, Jung KM, Piomelli D. Dysfunctional oleoylethanolamide signaling in a mouse model of Prader-Willi syndrome. Pharmacol Res. 2017 Mar; 117:75-81. PMID: 28007570.
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    31. Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I. Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission. Brain Struct Funct. 2017 Jul; 222(5):2345-2357. PMID: 27905022.
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    32. Romeo E, Pontis S, Ponzano S, Bonezzi F, Migliore M, Di Martino S, Summa M, Piomelli D. Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase. J Vis Exp. 2016 11 23; (117). PMID: 27911411.
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    33. Petracca R, Ponzano S, Bertozzi SM, Sasso O, Piomelli D, Bandiera T, Bertozzi F. Progress in the development of ß-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives. Eur J Med Chem. 2017 Jan 27; 126:561-575. PMID: 27915171.
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    34. Margheritis E, Castellani B, Magotti P, Peruzzi S, Romeo E, Natali F, Mostarda S, Gioiello A, Piomelli D, Garau G. Bile Acid Recognition by NAPE-PLD. ACS Chem Biol. 2016 10 21; 11(10):2908-2914. PMID: 27571266.
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    35. Moradi H, Oveisi F, Khanifar E, Moreno-Sanz G, Vaziri ND, Piomelli D. Increased Renal 2-Arachidonoylglycerol Level Is Associated with Improved Renal Function in a Mouse Model of Acute Kidney Injury. Cannabis Cannabinoid Res. 2016; 1(1):218-228. PMID: 28861493.
      View in: PubMed
    36. Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G. A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27517090; PMCID: PMC4976302.
    37. Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, Jung KM, Piomelli D, Mor M. Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Sci Rep. 2016 08 08; 6:31046. PMID: 27499063.
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    38. Sasso O, Pontis S, Armirotti A, Cardinali G, Kovacs D, Migliore M, Summa M, Moreno-Sanz G, Picardo M, Piomelli D. Endogenous N-acyl taurines regulate skin wound healing. Proc Natl Acad Sci U S A. 2016 07 26; 113(30):E4397-406. PMID: 27412859; PMCID: PMC4968764 [Available on 01/26/17].
    39. Migliore M, Pontis S, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 Sep 05; 55(37):11193-11197. PMID: 27404798; PMCID: PMC5009002 [Available on 09/05/17].
    40. Goldoni L, Beringhelli T, Rocchia W, Realini N, Piomelli D. Absolute nutrient concentration measurements in cell culture media: (1)H q-NMR spectra and data to compare the efficiency of pH-controlled protein precipitation versus CPMG or post-processing filtering approaches. Data Brief. 2016 Sep; 8:387-93. PMID: 27331118; PMCID: PMC4909824.
    41. Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 03 24; 59(6):2612-32. PMID: 26888301.
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    42. Goldoni L, Beringhelli T, Rocchia W, Realini N, Piomelli D. A simple and accurate protocol for absolute polar metabolite quantification in cell cultures using quantitative nuclear magnetic resonance. Anal Biochem. 2016 May 15; 501:26-34. PMID: 26898303.
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    43. Jacome-Sosa M, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field CJ, Igarashi M, Piomelli D, Banni S, Proctor SD. Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR:LA-cp rat. J Lipid Res. 2016 Apr; 57(4):638-49. PMID: 26891736; PMCID: PMC4808772 [Available on 04/01/17].
    44. Wei D, Lee D, Li D, Daglian J, Jung KM, Piomelli D. A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. Psychopharmacology (Berl). 2016 05; 233(10):1911-9. PMID: 26873082.
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    45. Basit A, Pontis S, Piomelli D, Armirotti A. Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics. Metabolomics. 2016; 12:50. PMID: 26900387.
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    46. Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH. Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism. 2016 07; 65(7):987-97. PMID: 27282869.
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    47. Piomelli D, Grant I. Medicinal Cannabis in California: An Interview with Igor Grant, MD. Cannabis Cannabinoid Res. 2016; 1(1):78-80. PMID: 28861482.
      View in: PubMed
    48. Wei D, Dinh D, Lee D, Li D, Anguren A, Moreno-Sanz G, Gall CM, Piomelli D. Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment. Cannabis Cannabinoid Res. 2016; 1(1):81-89. PMID: 28861483.
      View in: PubMed
    49. Nuzzi A, Fiasella A, Ortega JA, Pagliuca C, Ponzano S, Pizzirani D, Bertozzi SM, Ottonello G, Tarozzo G, Reggiani A, Bandiera T, Bertozzi F, Piomelli D. Potent a-amino-ß-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. Eur J Med Chem. 2016 Mar 23; 111:138-59. PMID: 26866968.
      View in: PubMed
    50. Bonezzi FT, Sasso O, Pontis S, Realini N, Romeo E, Ponzano S, Nuzzi A, Fiasella A, Bertozzi F, Piomelli D. An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis. J Pharmacol Exp Ther. 2016 Mar; 356(3):656-63. PMID: 26769918.
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    51. Piomelli D. Introduction to Cannabis and Cannabinoid Research. Cannabis Cannabinoid Res. 2016; 1(1):1-2. PMID: 28861473.
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    52. Piomelli D, Haney M, Budney AJ, Piazza PV. Legal or Illegal, Cannabis Is Still Addictive. Cannabis Cannabinoid Res. 2016; 1(1):47-53. PMID: 28861480.
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    53. Piomelli D, Russo EB. The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD. Cannabis Cannabinoid Res. 2016; 1(1):44-46. PMID: 28861479.
      View in: PubMed
    54. Jung KM, Piomelli D. Assay of Monoacylglycerol Lipase Activity. Methods Mol Biol. 2016; 1412:157-68. PMID: 27245902.
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    55. Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. Eur J Med Chem. 2016 Feb 15; 109:216-37. PMID: 26774927; PMCID: PMC4752335 [Available on 02/15/17].
    56. Veronesi M, Giacomina F, Romeo E, Castellani B, Ottonello G, Lambruschini C, Garau G, Scarpelli R, Bandiera T, Piomelli D, Dalvit C. Fluorine nuclear magnetic resonance-based assay in living mammalian cells. Anal Biochem. 2016 Feb 15; 495:52-9. PMID: 26686030.
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    57. Greco R, Bandiera T, Mangione AS, Demartini C, Nappi G, Sandrini G, Piomelli D, Tassorelli C. P007. Inhibition of monoacylglycerol lipase activity modulates the activation of brain structures relevant for migraine pathogenesis. J Headache Pain. 2015 Dec; 16(Suppl 1):A165. PMID: 28132223.
      View in: PubMed
    58. Bach A, Pizzirani D, Realini N, Vozella V, Russo D, Penna I, Melzig L, Scarpelli R, Piomelli D. Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. J Med Chem. 2015 Dec 10; 58(23):9258-72. PMID: 26560855.
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    59. Pontis S, Ribeiro A, Sasso O, Piomelli D. Macrophage-derived lipid agonists of PPAR-a as intrinsic controllers of inflammation. Crit Rev Biochem Mol Biol. 2016; 51(1):7-14. PMID: 26585314.
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    60. Panlilio LV, Thorndike EB, Nikas SP, Alapafuja SO, Bandiera T, Cravatt BF, Makriyannis A, Piomelli D, Goldberg SR, Justinova Z. Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. Psychopharmacology (Berl). 2016 05; 233(10):1879-88. PMID: 26558620.
      View in: PubMed
    61. Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016 Jan 29; 291(5):2422-34. PMID: 26553872; PMCID: PMC4732224 [Available on 01/29/17].
    62. Wei D, Lee D, Cox CD, Karsten CA, Peñagarikano O, Geschwind DH, Gall CM, Piomelli D. Endocannabinoid signaling mediates oxytocin-driven social reward. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14084-9. PMID: 26504214; PMCID: PMC4653148.
    63. Scarpelli R, Sasso O, Piomelli D. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. ChemMedChem. 2016 06 20; 11(12):1242-51. PMID: 26486424; PMCID: PMC4840092 [Available on 06/20/17].
    64. Lim J, Igarashi M, Jung KM, Butini S, Campiani G, Piomelli D. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. Neuropsychopharmacology. 2016 Apr; 41(5):1329-39. PMID: 26361059; PMCID: PMC4793117 [Available on 04/01/17].
    65. DiPatrizio NV, Igarashi M, Narayanaswami V, Murray C, Gancayco J, Russell A, Jung KM, Piomelli D. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R805-13. PMID: 26290104; PMCID: PMC4666947 [Available on 10/15/16].
    66. Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015; 10(8):e0135113. PMID: 26263173; PMCID: PMC4532501.
    67. Scalvini L, Piomelli D, Mor M. Monoglyceride lipase: Structure and inhibitors. Chem Phys Lipids. 2016 May; 197:13-24. PMID: 26216043; PMCID: PMC4728057 [Available on 05/01/17].
    68. Romeo E, Ponzano S, Armirotti A, Summa M, Bertozzi F, Garau G, Bandiera T, Piomelli D. Activity-Based Probe for N-Acylethanolamine Acid Amidase. ACS Chem Biol. 2015 Sep 18; 10(9):2057-2064. PMID: 26102511; PMCID: PMC4575644.
    69. Bilbao A, Serrano A, Cippitelli A, Pavón FJ, Giuffrida A, Suárez J, García-Marchena N, Baixeras E, Gómez de Heras R, Orio L, Alén F, Ciccocioppo R, Cravatt BF, Parsons LH, Piomelli D, Rodríguez de Fonseca F. Role of the satiety factor oleoylethanolamide in alcoholism. Addict Biol. 2016 Jul; 21(4):859-72. PMID: 26037332; PMCID: PMC4668242 [Available on 07/01/17].
    70. Igarashi M, DiPatrizio NV, Narayanaswami V, Piomelli D. Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents. Biochim Biophys Acta. 2015 Sep; 1851(9):1218-26. PMID: 26024927; PMCID: PMC4516666.
    71. Dotsey EY, Jung KM, Basit A, Wei D, Daglian J, Vacondio F, Armirotti A, Mor M, Piomelli D. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chem Biol. 2015 May 21; 22(5):619-28. PMID: 26000748; PMCID: PMC4459529.
    72. Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y. Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. J Physiol. 2015 Jun 01; 593(11):2527-45. PMID: 25728242; PMCID: PMC4461413.
    73. Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. ACS Chem Biol. 2015 Aug 21; 10(8):1838-46. PMID: 25874594; PMCID: PMC4546552.
    74. Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res. 2015 Jul; 97:7-15. PMID: 25882247; PMCID: PMC4464910.
    75. Justinova Z, Panlilio LV, Moreno-Sanz G, Redhi GH, Auber A, Secci ME, Mascia P, Bandiera T, Armirotti A, Bertorelli R, Chefer SI, Barnes C, Yasar S, Piomelli D, Goldberg SR. Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse. Neuropsychopharmacology. 2015 Aug; 40(9):2185-97. PMID: 25754762.
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    76. Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D. Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage. FASEB J. 2015 Jun; 29(6):2616-27. PMID: 25757568; PMCID: PMC4447230.
    77. Basit A, Piomelli D, Armirotti A. Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS. Anal Bioanal Chem. 2015 Jul; 407(17):5189-98. PMID: 25749796; PMCID: PMC4471391.
    78. Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G. Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. Structure. 2015 Mar 03; 23(3):598-604. PMID: 25684574.
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    79. Astarita G, Avanesian A, Grimaldi B, Realini N, Justinova Z, Panlilio LV, Basit A, Goldberg SR, Piomelli D. Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis. PLoS One. 2015; 10(2):e0116961. PMID: 25671639; PMCID: PMC4324822.
    80. DiPatrizio NV, Piomelli D. Intestinal lipid-derived signals that sense dietary fat. J Clin Invest. 2015 Mar 02; 125(3):891-8. PMID: 25642767; PMCID: PMC4362267.
    81. Greco R, Bandiera T, Mangione AS, Demartini C, Siani F, Nappi G, Sandrini G, Guijarro A, Armirotti A, Piomelli D, Tassorelli C. Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine. Cephalalgia. 2015 Oct; 35(12):1065-76. PMID: 25608877.
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    82. Ponzano S, Berteotti A, Petracca R, Vitale R, Mengatto L, Bandiera T, Cavalli A, Piomelli D, Bertozzi F, Bottegoni G. Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem. 2014 Dec 11; 57(23):10101-11. PMID: 25380517.
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    83. Pizzirani D, Bach A, Realini N, Armirotti A, Mengatto L, Bauer I, Girotto S, Pagliuca C, De Vivo M, Summa M, Ribeiro A, Piomelli D. Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angew Chem Int Ed Engl. 2015 Jan 07; 54(2):485-9. PMID: 25395373; PMCID: PMC4502975.
    84. Piomelli D, Hohmann AG, Seybold V, Hammock BD. A lipid gate for the peripheral control of pain. J Neurosci. 2014 Nov 12; 34(46):15184-91. PMID: 25392487; PMCID: PMC4228127.
    85. Colombano G, Albani C, Ottonello G, Ribeiro A, Scarpelli R, Tarozzo G, Daglian J, Jung KM, Piomelli D, Bandiera T. O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors. ChemMedChem. 2015 Feb; 10(2):380-95. PMID: 25338703; PMCID: PMC4384654.
    86. Moreno-Sanz G, Barrera B, Armirotti A, Bertozzi SM, Scarpelli R, Bandiera T, Prieto JG, Duranti A, Tarzia G, Merino G, Piomelli D. Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain. Pharmacol Res. 2014 Sep; 87:87-93. PMID: 24993496; PMCID: PMC4134960.
    87. Tinoco AB, Armirotti A, Isorna E, Delgado MJ, Piomelli D, de Pedro N. Role of oleoylethanolamide as a feeding regulator in goldfish. J Exp Biol. 2014 Aug 01; 217(Pt 15):2761-9. PMID: 24855680.
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    88. De Simone A, Ruda GF, Albani C, Tarozzo G, Bandiera T, Piomelli D, Cavalli A, Bottegoni G. Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase. Chem Commun (Camb). 2014 May 18; 50(38):4904-7. PMID: 24691497; PMCID: PMC4038168.
    89. Fiasella A, Nuzzi A, Summa M, Armirotti A, Tarozzo G, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. 3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration. ChemMedChem. 2014 Jul; 9(7):1602-14. PMID: 24828120; PMCID: PMC4224963.
    90. Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A. Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology. 2014 Oct; 39(11):2519-28. PMID: 24820537; PMCID: PMC4207337.
    91. Bandiera T, Ponzano S, Piomelli D. Advances in the discovery of N-acylethanolamine acid amidase inhibitors. Pharmacol Res. 2014 Aug; 86:11-7. PMID: 24798679; PMCID: PMC4117721.
    92. Piomelli D. A mighty (ochondrial) fight? Mol Metab. 2014 Jul; 3(4):345-6. PMID: 24944892; PMCID: PMC4060220.
    93. Armirotti A, Basit A, Realini N, Caltagirone C, Bossù P, Spalletta G, Piomelli D. Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia. Anal Biochem. 2014 Jun 15; 455:48-54. PMID: 24708938.
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    94. Piomelli D, Sasso O. Peripheral gating of pain signals by endogenous lipid mediators. Nat Neurosci. 2014 Feb; 17(2):164-74. PMID: 24473264; PMCID: PMC4020413.
    95. Piomelli D. A discount on cannabinoids. Biol Psychiatry. 2014 Mar 15; 75(6):432-4. PMID: 24560432.
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    96. Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. J Biol Chem. 2014 Feb 28; 289(9):6091-7. PMID: 24425865; PMCID: PMC3937675.
    97. Vitale R, Ottonello G, Petracca R, Bertozzi SM, Ponzano S, Armirotti A, Berteotti A, Dionisi M, Cavalli A, Piomelli D, Bandiera T, Bertozzi F. Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors. ChemMedChem. 2014 Feb; 9(2):323-36. PMID: 24403170.
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    98. Holman EA, Guijarro A, Lim J, Piomelli D. Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats. Psychosom Med. 2014 Jan; 76(1):20-28. PMID: 24367128; PMCID: PMC3988664.
    99. Veronesi M, Romeo E, Lambruschini C, Piomelli D, Bandiera T, Scarpelli R, Garau G, Dalvit C. Fluorine NMR-based screening on cell membrane extracts. ChemMedChem. 2014 Feb; 9(2):286-9. PMID: 24339446.
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    100. Iorio M, Sasso O, Maffioli SI, Bertorelli R, Monciardini P, Sosio M, Bonezzi F, Summa M, Brunati C, Bordoni R, Corti G, Tarozzo G, Piomelli D, Reggiani A, Donadio S. A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity. ACS Chem Biol. 2014 Feb 21; 9(2):398-404. PMID: 24191663.
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    101. O'Brien LD, Limebeer CL, Rock EM, Bottegoni G, Piomelli D, Parker LA. Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus). Br J Pharmacol. 2013 Nov; 170(5):1130-6. PMID: 23991698; PMCID: PMC3949659.
    102. Rasmussen JM, Entringer S, Nguyen A, van Erp TG, Burns J, Guijarro A, Oveisi F, Swanson JM, Piomelli D, Wadhwa PD, Buss C, Potkin SG. Brown adipose tissue quantification in human neonates using water-fat separated MRI. PLoS One. 2013; 8(10):e77907. PMID: 24205024; PMCID: PMC3813555.
    103. Llewellyn KJ, Nalbandian A, Jung KM, Nguyen C, Avanesian A, Mozaffar T, Piomelli D, Kimonis VE. Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease. Hum Mol Genet. 2014 Mar 01; 23(5):1333-44. PMID: 24158850; PMCID: PMC3919004.
    104. Ponzano S, Bertozzi F, Mengatto L, Dionisi M, Armirotti A, Romeo E, Berteotti A, Fiorelli C, Tarozzo G, Reggiani A, Duranti A, Tarzia G, Mor M, Cavalli A, Piomelli D, Bandiera T. Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem. 2013 Sep 12; 56(17):6917-34. PMID: 23991897.
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    105. Piomelli D. More surprises lying ahead. The endocannabinoids keep us guessing. Neuropharmacology. 2014 Jan; 76 Pt B:228-34. PMID: 23954677; PMCID: PMC3855347.
    106. Lambruschini C, Veronesi M, Romeo E, Garau G, Bandiera T, Piomelli D, Scarpelli R, Dalvit C. Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem. 2013 Sep 02; 14(13):1611-9. PMID: 23918626.
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    107. Moreno-Sanz G, Duranti A, Melzig L, Fiorelli C, Ruda GF, Colombano G, Mestichelli P, Sanchini S, Tontini A, Mor M, Bandiera T, Scarpelli R, Tarzia G, Piomelli D. Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. J Med Chem. 2013 Jul 25; 56(14):5917-30. PMID: 23822179; PMCID: PMC4062305.
    108. Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry. 2013 Sep; 18(9):1034-40. PMID: 23670490; PMCID: PMC3752332.
    109. Pizzirani D, Pagliuca C, Realini N, Branduardi D, Bottegoni G, Mor M, Bertozzi F, Scarpelli R, Piomelli D, Bandiera T. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem. 2013 May 09; 56(9):3518-30. PMID: 23614460.
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    110. Piomelli D. A fatty gut feeling. Trends Endocrinol Metab. 2013 Jul; 24(7):332-41. PMID: 23567058; PMCID: PMC3778443.
    111. Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors. J Med Chem. 2013 Mar 28; 56(6):2500-12. PMID: 23425199; PMCID: PMC3724458.
    112. DiPatrizio NV, Joslin A, Jung KM, Piomelli D. Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. FASEB J. 2013 Jun; 27(6):2513-20. PMID: 23463697; PMCID: PMC3659363.
    113. Capurro V, Busquet P, Lopes JP, Bertorelli R, Tarozzo G, Bolognesi ML, Piomelli D, Reggiani A, Cavalli A. Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease. PLoS One. 2013; 8(2):e56870. PMID: 23441223; PMCID: PMC3575497.
    114. Palermo G, Campomanes P, Neri M, Piomelli D, Cavalli A, Rothlisberger U, De Vivo M. Wagging the Tail: Essential Role of Substrate Flexibility in FAAH Catalysis. J Chem Theory Comput. 2013 Feb 12; 9(2):1202-13. PMID: 26588763.
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    115. Lopes JP, Tarozzo G, Reggiani A, Piomelli D, Cavalli A. Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity. Brain Behav. 2013 Mar; 3(2):67-74. PMID: 23532860; PMCID: PMC3607148.
    116. Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep. 2013; 3:1035. PMID: 23301156; PMCID: PMC3539145.
    117. Bertolacci L, Romeo E, Veronesi M, Magotti P, Albani C, Dionisi M, Lambruschini C, Scarpelli R, Cavalli A, De Vivo M, Piomelli D, Garau G. A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. J Am Chem Soc. 2013 Jan 09; 135(1):22-5. PMID: 23240907; PMCID: PMC3562592.
    118. Moreno-Sanz G, Sasso O, Guijarro A, Oluyemi O, Bertorelli R, Reggiani A, Piomelli D. Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. Br J Pharmacol. 2012 Dec; 167(8):1620-8. PMID: 22774772; PMCID: PMC3525865.
    119. Busquet P, Capurro V, Cavalli A, Piomelli D, Reggiani A, Bertorelli R. Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice. J Pharmacol Sci. 2012; 120(4):305-9. PMID: 23149577.
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    120. Sasso O, Moreno-Sanz G, Martucci C, Realini N, Dionisi M, Mengatto L, Duranti A, Tarozzo G, Tarzia G, Mor M, Bertorelli R, Reggiani A, Piomelli D. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar; 154(3):350-60. PMID: 23218523; PMCID: PMC3723234.
    121. Simoni E, Daniele S, Bottegoni G, Pizzirani D, Trincavelli ML, Goldoni L, Tarozzo G, Reggiani A, Martini C, Piomelli D, Melchiorre C, Rosini M, Cavalli A. Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. J Med Chem. 2012 Nov 26; 55(22):9708-21. PMID: 23033965.
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    122. Favia AD, Habrant D, Scarpelli R, Migliore M, Albani C, Bertozzi SM, Dionisi M, Tarozzo G, Piomelli D, Cavalli A, De Vivo M. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25; 55(20):8807-26. PMID: 23043222; PMCID: PMC3764917.
    123. Khasabova IA, Xiong Y, Coicou LG, Piomelli D, Seybold V. Peroxisome proliferator-activated receptor a mediates acute effects of palmitoylethanolamide on sensory neurons. J Neurosci. 2012 Sep 12; 32(37):12735-43. PMID: 22972997; PMCID: PMC3462371.
    124. Jumpertz R, Guijarro A, Pratley RE, Mason CC, Piomelli D, Krakoff J. Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism. PLoS One. 2012; 7(7):e41503. PMID: 22911803; PMCID: PMC3404019.
    125. Carloni S, Alonso-Alconada D, Girelli S, Duranti A, Tontini A, Piomelli D, Hilario E, Alvarez A, Balduini W. Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatr Res. 2012 Oct; 72(4):400-6. PMID: 22821058.
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    126. Gregg LC, Jung KM, Spradley JM, Nyilas R, Suplita RL, Zimmer A, Watanabe M, Mackie K, Katona I, Piomelli D, Hohmann AG. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-a initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 2012 Jul 11; 32(28):9457-68. PMID: 22787031; PMCID: PMC3652685.
    127. Vaidyanathan V, Bastarrachea RA, Higgins PB, Voruganti VS, Kamath S, DiPatrizio NV, Piomelli D, Comuzzie AG, Parks EJ. Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates. Am J Physiol Endocrinol Metab. 2012 Sep 01; 303(5):E624-34. PMID: 22761159; PMCID: PMC3468508.
    128. DiPatrizio NV, Piomelli D. The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends Neurosci. 2012 Jul; 35(7):403-11. PMID: 22622030; PMCID: PMC3744874.
    129. Duranti A, Tontini A, Antonietti F, Vacondio F, Fioni A, Silva C, Lodola A, Rivara S, Solorzano C, Piomelli D, Tarzia G, Mor M. N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. J Med Chem. 2012 May 24; 55(10):4824-36. PMID: 22515328.
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    130. Armirotti A, Romeo E, Ponzano S, Mengatto L, Dionisi M, Karacsonyi C, Bertozzi F, Garau G, Tarozzo G, Reggiani A, Bandiera T, Tarzia G, Mor M, Piomelli D. ß-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine. ACS Med Chem Lett. 2012 May 10; 3(5):422-6. PMID: 24900487; PMCID: PMC4025845.
    131. Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2012 Mar 20; 2:e94. PMID: 22832859; PMCID: PMC3316151.
    132. Jung KM, Clapper JR, Fu J, D'Agostino G, Guijarro A, Thongkham D, Avanesian A, Astarita G, DiPatrizio NV, Frontini A, Cinti S, Diano S, Piomelli D. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metab. 2012 Mar 07; 15(3):299-310. PMID: 22405068; PMCID: PMC3729112.
    133. Sasso O, Bertorelli R, Bandiera T, Scarpelli R, Colombano G, Armirotti A, Moreno-Sanz G, Reggiani A, Piomelli D. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacol Res. 2012 May; 65(5):553-63. PMID: 22420940; PMCID: PMC3738192.
    134. Lodola A, Branduardi D, De Vivo M, Capoferri L, Mor M, Piomelli D, Cavalli A. A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. PLoS One. 2012; 7(2):e32397. PMID: 22389698; PMCID: PMC3289653.
    135. Newberry EP, Kennedy SM, Xie Y, Luo J, Crooke RM, Graham MJ, Fu J, Piomelli D, Davidson NO. Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. J Lipid Res. 2012 Apr; 53(4):744-54. PMID: 22327204; PMCID: PMC3307651.
    136. Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN. Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Adv Nutr. 2012 Jan; 3(1):60-8. PMID: 22332103; PMCID: PMC3262616.
    137. Jung KM, Sepers M, Henstridge CM, Lassalle O, Neuhofer D, Martin H, Ginger M, Frick A, DiPatrizio NV, Mackie K, Katona I, Piomelli D, Manzoni OJ. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun. 2012; 3:1080. PMID: 23011134; PMCID: PMC3657999.
    138. Snigdha S, Astarita G, Piomelli D, Cotman CW. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012 Jan 27; 202:326-33. PMID: 22183056; PMCID: PMC3447971.
    139. Cippitelli A, Astarita G, Duranti A, Caprioli G, Ubaldi M, Stopponi S, Kallupi M, Sagratini G, Rodrìguez de Fonseca F, Piomelli D, Ciccocioppo R. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. PLoS One. 2011; 6(11):e28142. PMID: 22140525; PMCID: PMC3227620.
    140. Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci. 2011 Nov 20; 15(1):64-9. PMID: 22101642; PMCID: PMC3245783.
    141. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. PMID: 22046234; PMCID: PMC3202527.
    142. Piomelli D. A thickening network of lipids. Pain. 2012 Jan; 153(1):3-4. PMID: 22019134.
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    143. Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW. Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One. 2011; 6(9):e24652. PMID: 21931796; PMCID: PMC3172245.
    144. Palermo G, Branduardi D, Masetti M, Lodola A, Mor M, Piomelli D, Cavalli A, De Vivo M. Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. J Med Chem. 2011 Oct 13; 54(19):6612-23. PMID: 21830831; PMCID: PMC3774108.
    145. Guindon J, Guijarro A, Piomelli D, Hohmann AG. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Br J Pharmacol. 2011 Aug; 163(7):1464-78. PMID: 21198549; PMCID: PMC3165956.
    146. Vacondio F, Silva C, Lodola A, Carmi C, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Tarzia G, Mor M. Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability. Eur J Med Chem. 2011 Sep; 46(9):4466-73. PMID: 21820769; PMCID: PMC3714604.
    147. Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011 Sep 09; 286(36):31532-41. PMID: 21757729; PMCID: PMC3173121.
    148. Moreno-Sanz G, Barrera B, Guijarro A, d'Elia I, Otero JA, Alvarez AI, Bandiera T, Merino G, Piomelli D. The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacol Res. 2011 Oct; 64(4):359-63. PMID: 21767647; PMCID: PMC3729352.
    149. DiPatrizio NV, Astarita G, Schwartz G, Li X, Piomelli D. Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12904-8. PMID: 21730161; PMCID: PMC3150876.
    150. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid ß42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. PMID: 21546126.
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    151. Astarita G, Piomelli D. Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. Prostaglandins Leukot Essent Fatty Acids. 2011 Nov; 85(5):197-203. PMID: 21543199.
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    152. Jung KM, Astarita G, Thongkham D, Piomelli D. Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms. Mol Pharmacol. 2011 Jul; 80(1):60-7. PMID: 21493725; PMCID: PMC3127538.
    153. Fu J, Dipatrizio NV, Guijarro A, Schwartz GJ, Li X, Gaetani S, Astarita G, Piomelli D. Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. J Neurosci. 2011 Apr 13; 31(15):5730-6. PMID: 21490214; PMCID: PMC3084524.
    154. Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E, Guerci M, Piomelli D, Pender SL, MacDonald TT, Maccarrone M, Corazza GR. The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunol. 2011 Sep; 4(5):574-83. PMID: 21471961.
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    155. Mascia P, Pistis M, Justinova Z, Panlilio LV, Luchicchi A, Lecca S, Scherma M, Fratta W, Fadda P, Barnes C, Redhi GH, Yasar S, Le Foll B, Tanda G, Piomelli D, Goldberg SR. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry. 2011 Apr 01; 69(7):633-41. PMID: 20801430.
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    156. Ollero M, Astarita G, Guerrera IC, Sermet-Gaudelus I, Trudel S, Piomelli D, Edelman A. Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients. J Lipid Res. 2011 May; 52(5):1011-22. PMID: 21335323; PMCID: PMC3073467.
    157. Lodola A, Capoferri L, Rivara S, Chudyk E, Sirirak J, Dyguda-Kazimierowicz E, Andrzej Sokalski W, Mileni M, Tarzia G, Piomelli D, Mor M, Mulholland AJ. Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. Chem Commun (Camb). 2011 Mar 07; 47(9):2517-9. PMID: 21240393.
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    158. Zhu C, Solorzano C, Sahar S, Realini N, Fung E, Sassone-Corsi P, Piomelli D. Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Mol Pharmacol. 2011 Apr; 79(4):786-92. PMID: 21233218; PMCID: PMC3063731.
    159. Wang H, Astarita G, Taussig MD, Bharadwaj KG, DiPatrizio NV, Nave KA, Piomelli D, Goldberg IJ, Eckel RH. Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity. Cell Metab. 2011 Jan 05; 13(1):105-13. PMID: 21195353; PMCID: PMC3034302.
    160. Ollero M, Guerrera IC, Astarita G, Piomelli D, Edelman A. New lipidomic approaches in cystic fibrosis. Methods Mol Biol. 2011; 742:265-78. PMID: 21547738.
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    161. Jumpertz R, Guijarro A, Pratley RE, Piomelli D, Krakoff J. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. J Clin Endocrinol Metab. 2011 Mar; 96(3):787-91. PMID: 21177788; PMCID: PMC3047230.
    162. Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P. PER2 controls lipid metabolism by direct regulation of PPAR?. Cell Metab. 2010 Nov 03; 12(5):509-20. PMID: 21035761; PMCID: PMC4103168.
    163. Cassano T, Gaetani S, Macheda T, Laconca L, Romano A, Morgese MG, Cimmino CS, Chiarotti F, Bambico FR, Gobbi G, Cuomo V, Piomelli D. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology (Berl). 2011 Mar; 214(2):465-76. PMID: 21042794; PMCID: PMC3045513.
    164. Ludányi A, Hu SS, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, Katona I. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience. 2011 Feb 03; 174:50-63. PMID: 21035522; PMCID: PMC3678284.
    165. Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, Block ML, Zecca L, Hong JS, Dantzer R, Kelley KW, Craig AD. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nat Rev Neurosci. 2010 10; 11(10):718-26. PMID: 20852655.
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    166. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 2010 Oct; 13(10):1265-70. PMID: 20852626; PMCID: PMC3260554.
    167. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. PMID: 20838618; PMCID: PMC2935886.
    168. Solorzano C, Antonietti F, Duranti A, Tontini A, Rivara S, Lodola A, Vacondio F, Tarzia G, Piomelli D, Mor M. Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. J Med Chem. 2010 Aug 12; 53(15):5770-81. PMID: 20604568; PMCID: PMC2932887.
    169. Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology. 2010 Sep; 35(10):2083-100. PMID: 20571484; PMCID: PMC3055302.
    170. Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, Piomelli D. The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. J Neurosci. 2010 Jun 16; 30(24):8096-101. PMID: 20554860; PMCID: PMC2900249.
    171. Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010 May 28; 5(5):e10891. PMID: 20531936; PMCID: PMC2878341.
    172. Oddi S, Fezza F, Catanzaro G, De Simone C, Pucci M, Piomelli D, Finazzi-Agrò A, Maccarrone M. Pitfalls and solutions in assaying anandamide transport in cells. J Lipid Res. 2010 Aug; 51(8):2435-44. PMID: 20447929; PMCID: PMC2903826.
    173. Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG, Piomelli D. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience. 2010 Jun 30; 168(2):371-86. PMID: 20394803; PMCID: PMC2882942.
    174. Eisenstein SA, Clapper JR, Holmes PV, Piomelli D, Hohmann AG. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Pharmacol Res. 2010 May; 61(5):419-29. PMID: 20044005; PMCID: PMC2867105.
    175. Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-ß processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis. 2010; 22(1):135-50. PMID: 20847439.
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    176. Touriño C, Oveisi F, Lockney J, Piomelli D, Maldonado R. FAAH deficiency promotes energy storage and enhances the motivation for food. Int J Obes (Lond). 2010 Mar; 34(3):557-68. PMID: 20029375; PMCID: PMC3709605.
    177. Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20966-71. PMID: 19926854; PMCID: PMC2791595.
    178. Guerrera IC, Astarita G, Jais JP, Sands D, Nowakowska A, Colas J, Sermet-Gaudelus I, Schuerenberg M, Piomelli D, Edelman A, Ollero M. A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. PLoS One. 2009 Nov 06; 4(11):e7735. PMID: 19893743; PMCID: PMC2768907.
    179. King AR, Dotsey EY, Lodola A, Jung KM, Ghomian A, Qiu Y, Fu J, Mor M, Piomelli D. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol. 2009 Oct 30; 16(10):1045-52. PMID: 19875078; PMCID: PMC3034734.
    180. Guijarro A, Fu J, Astarita G, Piomelli D. CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice. Pharmacol Res. 2010 Jan; 61(1):27-33. PMID: 19778614; PMCID: PMC2846762.
    181. Vacondio F, Silva C, Lodola A, Fioni A, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Mor M, Tarzia G. Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability. ChemMedChem. 2009 Sep; 4(9):1495-504. PMID: 19554599; PMCID: PMC3517974.
    182. Clapper JR, Vacondio F, King AR, Duranti A, Tontini A, Silva C, Sanchini S, Tarzia G, Mor M, Piomelli D. A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo. ChemMedChem. 2009 Sep; 4(9):1505-13. PMID: 19637155; PMCID: PMC3016090.
    183. King AR, Lodola A, Carmi C, Fu J, Mor M, Piomelli D. A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors. Br J Pharmacol. 2009 Jul; 157(6):974-83. PMID: 19486005; PMCID: PMC2737656.
    184. Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, Piomelli D. Fat-induced satiety factor oleoylethanolamide enhances memory consolidation. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):8027-31. PMID: 19416833; PMCID: PMC2683095.
    185. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Loverme J, Piomelli D, Meli R, Calignano A. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. Eur J Pharmacol. 2009 Jun 24; 613(1-3):54-9. PMID: 19386271.
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    186. Mangieri RA, Hong KI, Piomelli D, Sinha R. An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. Psychopharmacology (Berl). 2009 Jul; 205(1):63-72. PMID: 19343330; PMCID: PMC2715164.
    187. Koethe D, Giuffrida A, Schreiber D, Hellmich M, Schultze-Lutter F, Ruhrmann S, Klosterkötter J, Piomelli D, Leweke FM. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. Br J Psychiatry. 2009 Apr; 194(4):371-2. PMID: 19336792.
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    188. Valitutti G, Duranti A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity. J Mass Spectrom. 2009 Apr; 44(4):561-5. PMID: 19034887.
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    189. Parker LA, Limebeer CL, Rock EM, Litt DL, Kwiatkowska M, Piomelli D. The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew). Physiol Behav. 2009 Apr 20; 97(1):121-4. PMID: 19239915; PMCID: PMC3781595.
    190. Piomelli D. Responses to stress: from the periphery to the brain. Curr Opin Pharmacol. 2009 Feb; 9(1):1-2. PMID: 19162545.
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    191. Astarita G, Piomelli D. Lipidomic analysis of endocannabinoid metabolism in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15; 877(26):2755-67. PMID: 19171504; PMCID: PMC2723187.
    192. Koethe D, Schreiber D, Giuffrida A, Mauss C, Faulhaber J, Heydenreich B, Hellmich M, Graf R, Klosterkötter J, Piomelli D, Leweke FM. Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. J Neural Transm (Vienna). 2009 Mar; 116(3):301-5. PMID: 19137236; PMCID: PMC2757605.
    193. Gaetani S, Dipasquale P, Romano A, Righetti L, Cassano T, Piomelli D, Cuomo V. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. Int Rev Neurobiol. 2009; 85:57-72. PMID: 19607961.
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    194. Astarita G, Geaga J, Ahmed F, Piomelli D. Targeted lipidomics as a tool to investigate endocannabinoid function. Int Rev Neurobiol. 2009; 85:35-55. PMID: 19607960.
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    195. Astarita G, Ahmed F, Piomelli D. Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry. Methods Mol Biol. 2009; 579:201-19. PMID: 19763477.
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    196. Cluny NL, Keenan CM, Lutz B, Piomelli D, Sharkey KA. The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice. Neurogastroenterol Motil. 2009 Apr; 21(4):420-9. PMID: 19140957.
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    197. Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid pain modulation with nuclear receptor ligands. Brain Res Rev. 2009 Apr; 60(1):114-24. PMID: 19162071; PMCID: PMC3695814.
    198. LoVerme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N, Xu C, Tarzia G, Piomelli D. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):639-43. PMID: 19128970; PMCID: PMC3690177.
    199. Duncan M, Thomas AD, Cluny NL, Patel A, Patel KD, Lutz B, Piomelli D, Alexander SP, Sharkey KA. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1255-65. PMID: 18948437.
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    200. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008 Oct; 8(4):281-288. PMID: 18840358; PMCID: PMC2572640.
    201. Justinova Z, Mangieri RA, Bortolato M, Chefer SI, Mukhin AG, Clapper JR, King AR, Redhi GH, Yasar S, Piomelli D, Goldberg SR. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biol Psychiatry. 2008 Dec 01; 64(11):930-7. PMID: 18814866.
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    202. Gaetani S, Kaye WH, Cuomo V, Piomelli D. Role of endocannabinoids and their analogues in obesity and eating disorders. Eat Weight Disord. 2008 Sep; 13(3):e42-8. PMID: 19011363.
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    203. Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinová Z, Mikics E, Haller J, Medalie J, Stroik J, Barnes C, Yasar S, Tanda G, Piomelli D, Fratta W, Goldberg SR. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. J Pharmacol Exp Ther. 2008 Nov; 327(2):482-90. PMID: 18725543.
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    204. Clapper JR, Mangieri RA, Piomelli D. The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology. 2009; 56 Suppl 1:235-43. PMID: 18691603; PMCID: PMC2647947.
    205. Piomelli D. The element of surprise. Nat Med. 2008 Jul; 14(7):720-1. PMID: 18607371.
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    206. Moise AM, Eisenstein SA, Astarita G, Piomelli D, Hohmann AG. An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology (Berl). 2008 Oct; 200(3):333-46. PMID: 18545985; PMCID: PMC2694060.
    207. Mor M, Lodola A, Rivara S, Vacondio F, Duranti A, Tontini A, Sanchini S, Piersanti G, Clapper JR, King AR, Tarzia G, Piomelli D. Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. J Med Chem. 2008 Jun 26; 51(12):3487-98. PMID: 18507372; PMCID: PMC3744893.
    208. Potvin S, Kouassi E, Lipp O, Bouchard RH, Roy MA, Demers MF, Gendron A, Astarita G, Piomelli D, Stip E. Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. J Psychopharmacol. 2008 May; 22(3):262-9. PMID: 18308802.
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    209. Koethe D, Bortolato M, Piomelli D, Leweke FM. Improvement of general symptoms in a chronic psychotic patient treated with finasteride: case report. Pharmacopsychiatry. 2008 May; 41(3):115-6. PMID: 18484553.
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    210. Cippitelli A, Cannella N, Braconi S, Duranti A, Tontini A, Bilbao A, Defonseca FR, Piomelli D, Ciccocioppo R. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. Psychopharmacology (Berl). 2008 Jul; 198(4):449-60. PMID: 18446329.
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    211. Fu J, Kim J, Oveisi F, Astarita G, Piomelli D. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R45-50. PMID: 18434444; PMCID: PMC2494809.
    212. Solinas M, Goldberg SR, Piomelli D. The endocannabinoid system in brain reward processes. Br J Pharmacol. 2008 May; 154(2):369-83. PMID: 18414385; PMCID: PMC2442437.
    213. Genovese T, Esposito E, Mazzon E, Di Paola R, Meli R, Bramanti P, Piomelli D, Calignano A, Cuzzocrea S. Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. J Pharmacol Exp Ther. 2008 Jul; 326(1):12-23. PMID: 18367664.
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    214. King AR, Duranti A, Tontini A, Rivara S, Rosengarth A, Clapper JR, Astarita G, Geaga JA, Luecke H, Mor M, Tarzia G, Piomelli D. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec; 14(12):1357-65. PMID: 18096504; PMCID: PMC2225625.
    215. Valitutti G, Duranti A, Lodola A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors. J Mass Spectrom. 2007 Dec; 42(12):1624-7. PMID: 18085570.
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    216. Rock EM, Limebeer CL, Mechoulam R, Piomelli D, Parker LA. The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat. Psychopharmacology (Berl). 2008 Feb; 196(3):389-95. PMID: 17992520.
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    217. La Rana G, Russo R, D'Agostino G, Sasso O, Raso GM, Iacono A, Meli R, Piomelli D, Calignano A. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors. Neuropharmacology. 2008 Mar; 54(3):521-9. PMID: 18093621.
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    218. Astarita G, Ahmed F, Piomelli D. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. J Lipid Res. 2008 Jan; 49(1):48-57. PMID: 17957091.
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    219. Lodola A, Mor M, Rivara S, Christov C, Tarzia G, Piomelli D, Mulholland AJ. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. Chem Commun (Camb). 2008 Jan 14; (2):214-6. PMID: 18092091.
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    220. Piomelli D, Astarita G, Rapaka R. A neuroscientist's guide to lipidomics. Nat Rev Neurosci. 2007 Oct; 8(10):743-54. PMID: 17882252.
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    221. Mangieri RA, Piomelli D. Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacol Res. 2007 Nov; 56(5):360-6. PMID: 17945507; PMCID: PMC2104793.
    222. Tarzia G, Antonietti F, Duranti A, Tontini A, Mor M, Rivara S, Traldi P, Astarita G, King A, Clapper JR, Piomelli D. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007 Sep; 97(9):887-94. PMID: 17970304.
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    223. Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, Mikics E, Haller J, Yasar S, Tanda G, Goldberg SR. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. 2008 Jan; 54(1):129-40. PMID: 17904589.
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    224. Vila A, Rosengarth A, Piomelli D, Cravatt B, Marnett LJ. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry. 2007 Aug 21; 46(33):9578-85. PMID: 17649977.
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    225. Cippitelli A, Bilbao A, Gorriti MA, Navarro M, Massi M, Piomelli D, Ciccocioppo R, Rodríguez de Fonseca F. The anandamide transport inhibitor AM404 reduces ethanol self-administration. Eur J Neurosci. 2007 Jul; 26(2):476-86. PMID: 17650118.
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    226. Jung KM, Astarita G, Zhu C, Wallace M, Mackie K, Piomelli D. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol Pharmacol. 2007 Sep; 72(3):612-21. PMID: 17584991.
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    227. Leweke FM, Giuffrida A, Koethe D, Schreiber D, Nolden BM, Kranaster L, Neatby MA, Schneider M, Gerth CW, Hellmich M, Klosterkötter J, Piomelli D. Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. Schizophr Res. 2007 Aug; 94(1-3):29-36. PMID: 17566707.
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    228. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Raso GM, Cuzzocrea S, Lo Verme J, Piomelli D, Meli R, Calignano A. Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice. J Pharmacol Exp Ther. 2007 Sep; 322(3):1137-43. PMID: 17565008.
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    229. Guindon J, LoVerme J, Piomelli D, Beaulieu P. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesth Analg. 2007 Jun; 104(6):1563-9, table of contents. PMID: 17513659.
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    230. Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry. 2007 Nov 15; 62(10):1103-10. PMID: 17511970.
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    231. Ferrer B, Bermúdez-Silva FJ, Bilbao A, Alvarez-Jaimes L, Sanchez-Vera I, Giuffrida A, Serrano A, Baixeras E, Khaturia S, Navarro M, Parsons LH, Piomelli D, Rodríguez de Fonseca F. Regulation of brain anandamide by acute administration of ethanol. Biochem J. 2007 May 15; 404(1):97-104. PMID: 17302558; PMCID: PMC1868843.
    232. Russo R, Loverme J, La Rana G, Compton TR, Parrott J, Duranti A, Tontini A, Mor M, Tarzia G, Calignano A, Piomelli D. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. J Pharmacol Exp Ther. 2007 Jul; 322(1):236-42. PMID: 17412883.
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    233. Russo R, LoVerme J, La Rana G, D'Agostino G, Sasso O, Calignano A, Piomelli D. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. Eur J Pharmacol. 2007 Jul 02; 566(1-3):117-9. PMID: 17434479; PMCID: PMC1997313.
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    235. Schreiber D, Harlfinger S, Nolden BM, Gerth CW, Jaehde U, Schömig E, Klosterkötter J, Giuffrida A, Astarita G, Piomelli D, Markus Leweke F. Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. Anal Biochem. 2007 Feb 15; 361(2):162-8. PMID: 17196922.
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    237. Cross-Mellor SK, Ossenkopp KP, Piomelli D, Parker LA. Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. Psychopharmacology (Berl). 2007 Feb; 190(2):135-43. PMID: 17111174.
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    242. Pintor A, Tebano MT, Martire A, Grieco R, Galluzzo M, Scattoni ML, Pèzzola A, Coccurello R, Felici F, Cuomo V, Piomelli D, Calamandrei G, Popoli P. The cannabinoid receptor agonist WIN 55,212-2 attenuates the effects induced by quinolinic acid in the rat striatum. Neuropharmacology. 2006 Oct; 51(5):1004-12. PMID: 16895732.
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    243. Clapper JR, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacol Res. 2006 Nov; 54(5):341-4. PMID: 16935521.
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    244. LoVerme J, Guzmán M, Gaetani S, Piomelli D. Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. J Biol Chem. 2006 Aug 11; 281(32):22815-8. PMID: 16785227.
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    245. Katona I, Urbán GM, Wallace M, Ledent C, Jung KM, Piomelli D, Mackie K, Freund TF. Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci. 2006 May 24; 26(21):5628-37. PMID: 16723519; PMCID: PMC1698282.
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    247. Bortolato M, Campolongo P, Mangieri RA, Scattoni ML, Frau R, Trezza V, La Rana G, Russo R, Calignano A, Gessa GL, Cuomo V, Piomelli D. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec; 31(12):2652-9. PMID: 16541083.
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    248. La Rana G, Russo R, Campolongo P, Bortolato M, Mangieri RA, Cuomo V, Iacono A, Raso GM, Meli R, Piomelli D, Calignano A. Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]. J Pharmacol Exp Ther. 2006 Jun; 317(3):1365-71. PMID: 16510698.
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    249. Jayamanne A, Greenwood R, Mitchell VA, Aslan S, Piomelli D, Vaughan CW. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol. 2006 Feb; 147(3):281-8. PMID: 16331291; PMCID: PMC1751298.
    250. Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 2006; 12(1):21-38. PMID: 16834756.
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    251. Tarzia G, Duranti A, Gatti G, Piersanti G, Tontini A, Rivara S, Lodola A, Plazzi PV, Mor M, Kathuria S, Piomelli D. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring. ChemMedChem. 2006 Jan; 1(1):130-9. PMID: 16892344.
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    252. Connell K, Bolton N, Olsen D, Piomelli D, Hohmann AG. Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia. Neurosci Lett. 2006 Apr 24; 397(3):180-4. PMID: 16378681.
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    253. Astarita G, Rourke BC, Andersen JB, Fu J, Kim JH, Bennett AF, Hicks JW, Piomelli D. Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus). Am J Physiol Regul Integr Comp Physiol. 2006 May; 290(5):R1407-12. PMID: 16373434.
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    256. Su HF, Samsamshariat A, Fu J, Shan YX, Chen YH, Piomelli D, Wang PH. Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. Endocrinology. 2006 Feb; 147(2):827-34. PMID: 16269455.
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    257. Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science. 2005 Oct 14; 310(5746):329-32. PMID: 16224028.
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    258. Storozhuk MV, Ivanova SY, Piomelli D. Presence of depolarization-induced suppression of inhibition in a fraction of gabaergic synaptic connections in rat neocortical cultures. Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 Sep-Oct; 55(5):581-5. PMID: 16316018.
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    259. Piomelli D. The challenge of brain lipidomics. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):23-34. PMID: 16099388.
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    260. Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):223-34. PMID: 16099407.
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    262. Makara JK, Mor M, Fegley D, Szabó SI, Kathuria S, Astarita G, Duranti A, Tontini A, Tarzia G, Rivara S, Freund TF, Piomelli D. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci. 2005 Sep; 8(9):1139-41. PMID: 16116451.
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    263. Solbrig MV, Adrian R, Baratta J, Piomelli D, Giuffrida A. A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. Exp Neurol. 2005 Aug; 194(2):355-62. PMID: 16022863.
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    264. Jung KM, Mangieri R, Stapleton C, Kim J, Fegley D, Wallace M, Mackie K, Piomelli D. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol Pharmacol. 2005 Nov; 68(5):1196-202. PMID: 16051747.
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    265. Lodola A, Mor M, Hermann JC, Tarzia G, Piomelli D, Mulholland AJ. QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation. Chem Commun (Camb). 2005 Sep 21; (35):4399-401. PMID: 16136230.
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    269. Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005 Jun; 48(8):1147-53. PMID: 15910890.
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    270. Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D. Regulation of food intake by oleoylethanolamide. Cell Mol Life Sci. 2005 Mar; 62(6):708-16. PMID: 15770421.
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    271. Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. 2005 Apr; 313(1):352-8. PMID: 15579492.
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    272. Basso E, Duranti A, Mor M, Piomelli D, Tontini A, Tarzia G, Traldi P. Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters. J Mass Spectrom. 2004 Dec; 39(12):1450-5. PMID: 15578755.
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    273. Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, Faulhaber J, Klosterkötter J, Piomelli D. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology. 2004 Nov; 29(11):2108-14. PMID: 15354183.
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    275. Lo Verme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D. The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol. 2005 Jan; 67(1):15-9. PMID: 15465922.
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    276. Dinh TP, Kathuria S, Piomelli D. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Mol Pharmacol. 2004 Nov; 66(5):1260-4. PMID: 15272052.
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    277. Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F, Freund TF. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur J Neurosci. 2004 Jul; 20(2):441-58. PMID: 15233753.
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    278. Hájos N, Kathuria S, Dinh T, Piomelli D, Freund TF. Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: effects of low temperature and the transport inhibitor AM404. Eur J Neurosci. 2004 Jun; 19(11):2991-6. PMID: 15182306.
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    281. Guzmán M, Lo Verme J, Fu J, Oveisi F, Blázquez C, Piomelli D. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem. 2004 Jul 02; 279(27):27849-54. PMID: 15123613.
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    282. Piomelli D. THC: moderation during implantation. Nat Med. 2004 Jan; 10(1):19-20. PMID: 14702623.
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    284. Murillo-Rodriguez E, Blanco-Centurion C, Sanchez C, Piomelli D, Shiromani PJ. Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. Sleep. 2003 Dec 15; 26(8):943-7. PMID: 14746372.
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    285. Sparling PB, Giuffrida A, Piomelli D, Rosskopf L, Dietrich A. Exercise activates the endocannabinoid system. Neuroreport. 2003 Dec 02; 14(17):2209-11. PMID: 14625449.
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    288. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodríguez De Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G, Piomelli D. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 2003 Sep 04; 425(6953):90-3. PMID: 12955147.
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    289. Ferrer B, Asbrock N, Kathuria S, Piomelli D, Giuffrida A. Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. Eur J Neurosci. 2003 Sep; 18(6):1607-14. PMID: 14511339.
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    291. Chen K, Ratzliff A, Hilgenberg L, Gulyás A, Freund TF, Smith M, Dinh TP, Piomelli D, Mackie K, Soltesz I. Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron. 2003 Aug 14; 39(4):599-611. PMID: 12925275.
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    292. Freund TF, Katona I, Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol Rev. 2003 Jul; 83(3):1017-66. PMID: 12843414.
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    293. Tarzia G, Duranti A, Tontini A, Piersanti G, Mor M, Rivara S, Plazzi PV, Park C, Kathuria S, Piomelli D. Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. J Med Chem. 2003 Jun 05; 46(12):2352-60. PMID: 12773040.
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    294. Gaetani S, Oveisi F, Piomelli D. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology. 2003 Jul; 28(7):1311-6. PMID: 12700681.
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    295. Schuel H, Burkman LJ, Lippes J, Crickard K, Forester E, Piomelli D, Giuffrida A. N-Acylethanolamines in human reproductive fluids. Chem Phys Lipids. 2002 Dec 31; 121(1-2):211-27. PMID: 12505702.
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    296. Dinh TP, Freund TF, Piomelli D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids. 2002 Dec 31; 121(1-2):149-58. PMID: 12505697.
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    298. Del Arco I, Navarro M, Bilbao A, Ferrer B, Piomelli D, Rodríguez De Fonseca F. Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404. Eur J Pharmacol. 2002 Nov 01; 454(1):103-4. PMID: 12409011.
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    299. Gómez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodríguez de Fonseca F. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci. 2002 Nov 01; 22(21):9612-7. PMID: 12417686.
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    300. Schäbitz WR, Giuffrida A, Berger C, Aschoff A, Schwaninger M, Schwab S, Piomelli D. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. Stroke. 2002 Aug; 33(8):2112-4. PMID: 12154273.
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    307. Rodríguez De Fonseca F, Gorriti MA, Bilbao A, Escuredo L, García-Segura LM, Piomelli D, Navarro M. Role of the endogenous cannabinoid system as a modulator of dopamine transmission: implications for Parkinson's disease and schizophrenia. Neurotox Res. 2001 Jan; 3(1):23-35. PMID: 15111259.
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    308. Piomelli D. The ligand that came from within. Trends Pharmacol Sci. 2001 Jan; 22(1):17-9. PMID: 11165666.
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    310. Calignano A, Kátona I, Désarnaud F, Giuffrida A, La Rana G, Mackie K, Freund TF, Piomelli D. Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature. 2000 Nov 02; 408(6808):96-101. PMID: 11081515.
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    313. Beltramo M, de Fonseca FR, Navarro M, Calignano A, Gorriti MA, Grammatikopoulos G, Sadile AG, Giuffrida A, Piomelli D. Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. J Neurosci. 2000 May 01; 20(9):3401-7. PMID: 10777802.
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    316. Giuffrida A, Désarnaud F, Piomelli D. Endogenous cannabinoid signaling and psychomotor disorders. Prostaglandins Other Lipid Mediat. 2000 Apr; 61(1-2):63-70. PMID: 10785542.
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    317. Piomelli D. Pot of gold for glioma therapy. Nat Med. 2000 Mar; 6(3):255-6. PMID: 10700220.
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    326. Giuffrida A, Piomelli D. Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma. FEBS Lett. 1998 Feb 06; 422(3):373-6. PMID: 9498819.
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    327. Calignano A, La Rana G, Makriyannis A, Lin SY, Beltramo M, Piomelli D. Inhibition of intestinal motility by anandamide, an endogenous cannabinoid. Eur J Pharmacol. 1997 Dec 11; 340(2-3):R7-8. PMID: 9537804.
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    328. Calignano A, La Rana G, Beltramo M, Makriyannis A, Piomelli D. Potentiation of anandamide hypotension by the transport inhibitor, AM404. Eur J Pharmacol. 1997 Oct 15; 337(1):R1-2. PMID: 9389389.
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    329. Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science. 1997 Aug 22; 277(5329):1094-7. PMID: 9262477.
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    330. Stella N, Schweitzer P, Piomelli D. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997 Aug 21; 388(6644):773-8. PMID: 9285589.
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    331. Stella N, Estellés A, Siciliano J, Tencé M, Desagher S, Piomelli D, Glowinski J, Prémont J. Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes. J Neurosci. 1997 May 01; 17(9):2939-46. PMID: 9096130.
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    332. Beltramo M, di Tomaso E, Piomelli D. Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one. FEBS Lett. 1997 Feb 24; 403(3):263-7. PMID: 9091314.
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    333. Cadas H, di Tomaso E, Piomelli D. Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J Neurosci. 1997 Feb 15; 17(4):1226-42. PMID: 9006968.
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    334. Di Tomaso E, Cadas H, Gaillet S, Beltramo M, Desarnaud F, Venance L, Piomelli D. Endogenous lipids that activate cannabinoid receptors. Formation and inactivation. Adv Exp Med Biol. 1997; 407:335-40. PMID: 9321973.
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    335. Cadas H, Schinelli S, Piomelli D. Membrane localization of N-acylphosphatidylethanolamine in central neurons: studies with exogenous phospholipases. J Lipid Mediat Cell Signal. 1996 Sep; 14(1-3):63-70. PMID: 8906547.
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    336. di Tomaso E, Beltramo M, Piomelli D. Brain cannabinoids in chocolate. Nature. 1996 Aug 22; 382(6593):677-8. PMID: 8751435.
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    337. Cadas H, Gaillet S, Beltramo M, Venance L, Piomelli D. Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP. J Neurosci. 1996 Jun 15; 16(12):3934-42. PMID: 8656287.
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    338. Fontana A, Di Marzo V, Cadas H, Piomelli D. Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines. Prostaglandins Leukot Essent Fatty Acids. 1995 Oct; 53(4):301-8. PMID: 8577784.
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    339. Venance L, Piomelli D, Glowinski J, Giaume C. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature. 1995 Aug 17; 376(6541):590-4. PMID: 7637807.
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    340. Desarnaud F, Cadas H, Piomelli D. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. J Biol Chem. 1995 Mar 17; 270(11):6030-5. PMID: 7890734.
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    341. Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, Piomelli D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 1994 Dec 15; 372(6507):686-91. PMID: 7990962.
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    342. Di Marzo V, Vial D, Sokoloff P, Schwartz JC, Piomelli D. Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C. J Neurosci. 1993 Nov; 13(11):4846-53. PMID: 7693893.
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    343. Piomelli D, Di Marzo V. Dopamine D2 receptor signaling via the arachidonic acid cascade: modulation by cAMP-dependent protein kinase A and prostaglandin E2. J Lipid Mediat. 1993 Mar-Apr; 6(1-3):433-43. PMID: 8395253.
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    344. Di Marzo V, Piomelli D. Participation of prostaglandin E2 in dopamine D2 receptor-dependent potentiation of arachidonic acid release. J Neurochem. 1992 Jul; 59(1):379-82. PMID: 1351931.
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    345. Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature. 1991 Sep 12; 353(6340):164-7. PMID: 1909771.
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    346. Calignano A, Piomelli D, Sacktor TC, Schwartz JH. A phospholipase A2-stimulating protein regulated by protein kinase C in Aplysia neurons. Brain Res Mol Brain Res. 1991 Mar; 9(4):347-51. PMID: 1645437.
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    347. Piomelli D, Greengard P. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling. Trends Pharmacol Sci. 1990 Sep; 11(9):367-73. PMID: 2122564.
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    348. Piomelli D, Wang JK, Sihra TS, Nairn AC, Czernik AJ, Greengard P. Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8550-4. PMID: 2554319; PMCID: PMC298320.
    349. Piomelli D, Shapiro E, Zipkin R, Schwartz JH, Feinmark SJ. Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-icosatrienoic acid in Aplysia: a possible second messenger in neurons. Proc Natl Acad Sci U S A. 1989 Mar; 86(5):1721-5. PMID: 2493649; PMCID: PMC286773.
    350. Piomelli D, Feinmark SJ, Shapiro E, Schwartz JH. 12-keto-eicosatetraenoic acid. A biologically active eicosanoid in the nervous system of Aplysia. Ann N Y Acad Sci. 1989; 559:208-18. PMID: 2774398.
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    351. Piomelli D, Feinmark SJ, Shapiro E, Schwartz JH. Formation and biological activity of 12-ketoeicosatetraenoic acid in the nervous system of Aplysia. J Biol Chem. 1988 Nov 15; 263(32):16591-6. PMID: 3182804.
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    352. Shapiro E, Piomelli D, Feinmark S, Vogel S, Chin G, Schwartz JH. The role of arachidonic acid metabolites in signal transduction in an identified neural network mediating presynaptic inhibition in Aplysia. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:425-33. PMID: 3151176.
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    353. Piomelli D, Shapiro E, Feinmark SJ, Schwartz JH. Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation. J Neurosci. 1987 Nov; 7(11):3675-86. PMID: 3119791.
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    354. Piomelli D, Volterra A, Dale N, Siegelbaum SA, Kandel ER, Schwartz JH, Belardetti F. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature. 1987 Jul 2-8; 328(6125):38-43. PMID: 2439918.
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