Daniele Piomelli

Title(s)Professor, Anatomy and Neurobiology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9179, 7080
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    Collapse Research 
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    The lipid amidase NAAA as a therapeutic target for Alzheimer's disease
    NIH RF1AG065329Sep 15, 2020 - Aug 31, 2024
    Role: Principal Investigator
    Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain.
    NIH R41NS106999Sep 30, 2018 - Sep 29, 2020
    Role: Principal Investigator
    ICAL: Impact of Cannabinoids Across Lifespan
    NIH P50DA044118Jul 1, 2018 - May 31, 2022
    Role: Principal Investigator
    Peripheral FAAH as a target for novel analgesics
    NIH R42DA033683Mar 15, 2017 - Nov 30, 2020
    Role: Principal Investigator
    A Protective role for 2-AG in age-dependent cognitive impairment.
    NIH R21AG052336Aug 15, 2016 - May 31, 2018
    Role: Principal Investigator
    Lipidomics analysis of identified single neurons in the adult rodent brain
    NIH R21DA041776Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    A new treatment for NSAID-associated gastrointestinal damage
    NIH R41DK104489Jul 1, 2015 - Jun 30, 2016
    Role: Principal Investigator
    Optimization and preclinical development of FAAH inhibitors for smoking cessation
    NIH DP1DA031387Sep 30, 2010 - Jul 31, 2016
    Role: Principal Investigator
    Lipid biosignatures of drug addiction
    NIH RC2DA028902Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Role of endocannabinoid signaling in stress-coping behavior
    NIH RL1AA017538Sep 30, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Role of oleoylethanolamide in the control of food intake
    NIH R01DK073955Apr 1, 2007 - Jun 30, 2011
    Role: Principal Investigator
    Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    NIH R21DA022702Sep 30, 2006 - Jul 31, 2010
    Role: Principal Investigator
    Oleylethanolamide derivatives as anti-obesity agents
    NIH R41DK070347Sep 20, 2005 - Aug 31, 2006
    Role: Principal Investigator
    NIH T32DA007318Sep 1, 2001 - Jun 30, 2008
    Role: Principal Investigator
    NIH R01DA012653Aug 1, 1999 - May 31, 2005
    Role: Principal Investigator
    Characterization of Anandamide Transport in Brain
    NIH R01DA012413Aug 14, 1998 - Jun 30, 2017
    Role: Principal Investigator
    Characterization of a novel brain cannabinoid ligand
    NIH R01DA012447Aug 14, 1998 - Jul 31, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine. J Headache Pain. 2022 Jul 07; 23(1):79. Greco R, Demartini C, Zanaboni AM, Francavilla M, Reggiani A, Realini N, Scarpelli R, Piomelli D, Tassorelli C. PMID: 35799128; PMCID: PMC9264488.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism. Pharmacol Res. 2022 08; 182:106338. Palese F, Pontis S, Realini N, Torrens A, Ahmed F, Assogna F, Pellicano C, Bossù P, Spalletta G, Green K, Piomelli D. PMID: 35781057.
      View in: PubMed   Mentions:    Fields:    
    3. Diet-Induced Obesity Disrupts Histamine-Dependent Oleoylethanolamide Signaling in the Mouse Liver. Pharmacology. 2022; 107(7-8):423-432. Lin L, Mabou Tagne A, Squire EN, Lee HL, Fotio Y, Ramirez J, Zheng M, Torrens A, Ahmed F, Ramos R, Plikus MV, Piomelli D. PMID: 35691287.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood. Biol Psychiatry. 2022 Dec 01; 92(11):845-860. Lee HL, Jung KM, Fotio Y, Squire E, Palese F, Lin L, Torrens A, Ahmed F, Mabou Tagne A, Ramirez J, Su S, Wong CR, Jung DH, Scarfone VM, Nguyen PU, Wood M, Green K, Piomelli D. PMID: 35750512.
      View in: PubMed   Mentions:    Fields:    
    5. Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male and Female Rats. Cannabis Cannabinoid Res. 2022 Mar 28. Torrens A, Roy P, Lin L, Vu C, Grimes D, Inshishian VC, Montesinos JS, Ahmed F, Mahler SV, Huestis MA, Das A, Piomelli D. PMID: 35353551.
      View in: PubMed   Mentions:    Fields:    
    6. Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity. Metabolism. 2022 06; 131:155181. Du K, Sun L, Luo Z, Cao Y, Sun Q, Zhang K, Faizy A, Piomelli D, Lu X, Shan J, Yang Q. PMID: 35311662; PMCID: PMC8930181.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Call for Special Issue Papers: Sex and Gender Differences: Focus on Cannabis and Cannabinoids. Cannabis Cannabinoid Res. 2022 02; 7(1):1-2. Piomelli D. PMID: 35100054; PMCID: PMC8864728.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):1411-1423. Ghidini A, Scalvini L, Palese F, Lodola A, Mor M, Piomelli D. PMID: 34256657; PMCID: PMC8279155.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Call for Special Issue Papers: Sex and Gender Differences: Focus on Cannabis and Cannabinoids. Cannabis Cannabinoid Res. 2021 12; 6(6):449-450. Piomelli D. PMID: 34898257; PMCID: PMC8817679.
      View in: PubMed   Mentions:    Fields:    
    10. Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects. J Natl Cancer Inst Monogr. 2021 11 28; 2021(58):78-85. Ward SJ, Lichtman AH, Piomelli D, Parker LA. PMID: 34850893; PMCID: PMC8848502.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents. Neurobiol Dis. 2022 01; 162:105565. Le AA, Quintanilla J, Amani M, Piomelli D, Lynch G, Gall CM. PMID: 34838664.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. NAAA-regulated lipid signaling governs the transition from acute to chronic pain. Sci Adv. 2021 Oct 22; 7(43):eabi8834. Fotio Y, Jung KM, Palese F, Obenaus A, Tagne AM, Lin L, Rashid TI, Pacheco R, Jullienne A, Ramirez J, Mor M, Spadoni G, Jang C, Hohmann AG, Piomelli D. PMID: 34678057; PMCID: PMC8535814.
      View in: PubMed   Mentions: 2     Fields:    
    13. Publisher Correction: Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin. Sci Rep. 2021 Oct 07; 11(1):20330. Lai M, Amato R, La Rocca V, Bilgin M, Freer G, Spezia P, Quaranta P, Piomelli D, Pistello M. PMID: 34621010; PMCID: PMC8497496.
      View in: PubMed   Mentions:    Fields:    
    14. Endocannabinoid-Based Therapies. Annu Rev Pharmacol Toxicol. 2022 01 06; 62:483-507. Piomelli D, Mabou Tagne A. PMID: 34516291.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    15. Pharmacokinetic and pharmacodynamic properties of aerosolized ("vaped") THC in adolescent male and female rats. Psychopharmacology (Berl). 2021 Dec; 238(12):3595-3605. Ruiz CM, Torrens A, Lallai V, Castillo E, Manca L, Martinez MX, Justeson DN, Fowler CD, Piomelli D, Mahler SV. PMID: 34495367; PMCID: PMC8665923.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. Frequent Δ9- tetrahydrocannabinol exposure during adolescence impairs sociability in adult mice exposed to an aversive painful stimulus. Eur Neuropsychopharmacol. 2021 12; 53:19-24. Mabou Tagne A, Fotio Y, Alan Springs Z, Su S, Piomelli D. PMID: 34358818.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Pancreatic Pain-Knowledge Gaps and Research Opportunities in Children and Adults: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2021 08 01; 50(7):906-915. Uc A, Andersen DK, Apkarian AV, Bellin MD, Colloca L, Drewes AM, Dunbar EK, Forsmark CE, Goodman MT, Kapural L, Koob GF, Palermo TM, Pandol SJ, Pasricha P, Phillips AE, Piomelli D, Saloman JL, Schwarzenberg SJ, Singh VK, Sowa G, Strouse T, Treisman GJ, Windsor JA, Yadav D. PMID: 34643606.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Persistent Exposure to Δ9-Tetrahydrocannabinol during Adolescence Does Not Affect Nociceptive Responding in Adult Mice. J Pharmacol Exp Ther. 2021 09; 378(3):215-221. Mabou Tagne A, Fotio Y, Ibne Rashid T, Piomelli D. PMID: 34183435.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin. Sci Rep. 2021 05 27; 11(1):11221. Lai M, Amato R, La Rocca V, Bilgin M, Freer G, Spezia P, Quaranta P, Piomelli D, Pistello M. PMID: 34045496; PMCID: PMC8159975.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 08; 378(2):70-76. Fotio Y, Sasso O, Ciccocioppo R, Piomelli D. PMID: 33986036.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    21. Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells. Int J Mol Sci. 2021 Mar 23; 22(6). Lai M, La Rocca V, Amato R, Freer G, Costa M, Spezia PG, Quaranta P, Lombardo G, Piomelli D, Pistello M. PMID: 33806766; PMCID: PMC8004726.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain. Pharmacol Res. 2021 05; 167:105545. Mabou Tagne A, Fotio Y, Lin L, Squire E, Ahmed F, Rashid TI, Karimian Azari E, Piomelli D. PMID: 33722712.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 02 25; 29(24):3945-3953. Weiss L, Jung KM, Nalbandian A, Llewellyn K, Yu H, Ta L, Chang I, Migliore M, Squire E, Ahmed F, Piomelli D, Kimonis V. PMID: 33410456; PMCID: PMC8485215.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Impact of Circulating N-Acylethanolamine Levels with Clinical and Laboratory End Points in Hemodialysis Patients. Am J Nephrol. 2021; 52(1):59-68. Pai AY, Wenziger C, Streja E, Argueta DA, DiPatrizio NV, Rhee CM, Vaziri ND, Kalantar-Zadeh K, Piomelli D, Moradi H. PMID: 33601382; PMCID: PMC7987690.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis. Mol Metab. 2021 05; 47:101174. Hundahl C, Kotzbeck P, Burm HB, Christiansen SH, Torz L, Helge AW, Madsen MP, Ratner C, Serup AK, Thompson JJ, Eichmann TO, Pers TH, Woldbye DPD, Piomelli D, Kiens B, Zechner R, Skov LJ, Holst B. PMID: 33549847; PMCID: PMC7903013.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. The endocannabinoid system in the adipose organ. Rev Endocr Metab Disord. 2022 02; 23(1):51-60. Jung KM, Lin L, Piomelli D. PMID: 33387286; PMCID: PMC8776163.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    27. Cannabinoids in periodontal disease amid the COVID-19 pandemic. J Periodontal Implant Sci. 2020 Dec; 50(6):355-357. Park JB, Jung KM, Piomelli D. PMID: 33350175; PMCID: PMC7758300.
      View in: PubMed   Mentions: 1  
    28. Retraction Note: Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology. 2020 Dec; 45(13):2302. Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A. PMID: 32901117; PMCID: PMC7785013.
      View in: PubMed   Mentions:    Fields:    
    29. Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine. Neurobiol Dis. 2021 01; 147:105157. Greco R, Demartini C, Zanaboni A, Casini I, De Icco R, Reggiani A, Misto A, Piomelli D, Tassorelli C. PMID: 33129939.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    30. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2021 Jan; 238(1):249-258. Fotio Y, Ciccocioppo R, Piomelli D. PMID: 33037452; PMCID: PMC7796956.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    31. NAPE-specific phospholipase D regulates LRRK2 association with neuronal membranes. Adv Pharmacol. 2021; 90:217-238. Palese F, Pontis S, Realini N, Piomelli D. PMID: 33706934.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    32. Pharmacokinetic, behavioral, and brain activity effects of Δ9-tetrahydrocannabinol in adolescent male and female rats. Neuropsychopharmacology. 2021 04; 46(5):959-969. Ruiz CM, Torrens A, Castillo E, Perrone CR, Cevallos J, Inshishian VC, Harder EV, Justeson DN, Huestis MA, Swarup V, Piomelli D, Mahler SV. PMID: 32927465; PMCID: PMC8115040.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    33. N-Acylethanolamine Acid Amidase contributes to disease progression in a mouse model of multiple sclerosis. Pharmacol Res. 2020 10; 160:105064. Pontis S, Palese F, Summa M, Realini N, Lanfranco M, De Mei C, Piomelli D. PMID: 32634582.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. Cannabinoid CB2 receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear. Neuropsychopharmacology. 2020 07; 45(8):1330-1338. Ivy D, Palese F, Vozella V, Fotio Y, Yalcin A, Ramirez G, Mears D, Wynn G, Piomelli D. PMID: 32375160; PMCID: PMC7298057.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    35. Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice. J Pharmacol Exp Ther. 2020 07; 374(1):151-160. Torrens A, Vozella V, Huff H, McNeil B, Ahmed F, Ghidini A, Mahler SV, Huestis MA, Das A, Piomelli D. PMID: 32345621; PMCID: PMC7318794.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    36. The Synthetic Cannabinoid URB447 Reduces Brain Injury and the Associated White Matter Demyelination after Hypoxia-Ischemia in Neonatal Rats. ACS Chem Neurosci. 2020 05 06; 11(9):1291-1299. Carloni S, Crinelli R, Palma L, Álvarez FJ, Piomelli D, Duranti A, Balduini W, Alonso-Alconada D. PMID: 32271539; PMCID: PMC7997380.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    37. Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice. Br J Pharmacol. 2020 07; 177(13):3024-3035. Fotio Y, Palese F, Guaman Tipan P, Ahmed F, Piomelli D. PMID: 32077093; PMCID: PMC7280000.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    38. N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition. J Med Chem. 2020 07 23; 63(14):7475-7490. Piomelli D, Scalvini L, Fotio Y, Lodola A, Spadoni G, Tarzia G, Mor M. PMID: 32191459.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    39. Next Stop for Fatty Acid Amide Hydrolase Inhibitors, the Clinic? Biol Psychiatry. 2020 03 15; 87(6):485-486. Piomelli D. PMID: 32081250.
      View in: PubMed   Mentions: 1     Fields:    
    40. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiat Res. 2020 05; 193(5):407-424. Dey D, Parihar VK, Szabo GG, Klein PM, Tran J, Moayyad J, Ahmed F, Nguyen QA, Murry A, Merriott D, Nguyen B, Goldman J, Angulo MC, Piomelli D, Soltesz I, Baulch JE, Limoli CL. PMID: 32134362; PMCID: PMC7334540.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    41. Exposure to the cannabinoid agonist WIN 55, 212-2 in adolescent rats causes sleep alterations that persist until adulthood. Eur J Pharmacol. 2020 May 05; 874:172911. Macías-Triana L, Romero-Cordero K, Tatum-Kuri A, Vera-Barrón A, Millán-Aldaco D, Arankowsky-Sandoval G, Piomelli D, Murillo-Rodríguez E. PMID: 32045604.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    42. Circulating Endocannabinoids and Mortality in Hemodialysis Patients. Am J Nephrol. 2020; 51(2):86-95. Moradi H, Park C, Streja E, Argueta DA, DiPatrizio NV, You AS, Rhee CM, Vaziri ND, Kalantar-Zadeh K, Piomelli D. PMID: 31935741; PMCID: PMC7158229.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    43. Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign. Eur J Med Chem. 2020 Mar 01; 189:112047. Linciano P, Cullia G, Borsari C, Santucci M, Ferrari S, Witt G, Gul S, Kuzikov M, Ellinger B, Santarém N, Cordeiro da Silva A, Conti P, Bolognesi ML, Roberti M, Prati F, Bartoccini F, Retini M, Piersanti G, Cavalli A, Goldoni L, Bertozzi SM, Bertozzi F, Brambilla E, Rizzo V, Piomelli D, Pinto A, Bandiera T, Costi MP. PMID: 31982652.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    44. Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines. J Med Chem. 2020 02 13; 63(3):1261-1280. Castelli R, Scalvini L, Vacondio F, Lodola A, Anselmi M, Vezzosi S, Carmi C, Bassi M, Ferlenghi F, Rivara S, Møller IR, Rand KD, Daglian J, Wei D, Dotsey EY, Ahmed F, Jung KM, Stella N, Singh S, Mor M, Piomelli D. PMID: 31714779.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    45. A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration. Sci Rep. 2019 11 04; 9(1):15927. Palese F, Pontis S, Realini N, Piomelli D. PMID: 31685899; PMCID: PMC6828692.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    46. FAAH inhibition as a preventive treatment for migraine: A pre-clinical study. Neurobiol Dis. 2020 02; 134:104624. Greco R, Demartini C, Zanaboni AM, Tumelero E, Reggiani A, Misto A, Piomelli D, Tassorelli C. PMID: 31629892.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    47. Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats. J Pharm Pharmacol. 2019 Dec; 71(12):1762-1773. Vozella V, Ahmed F, Choobchian P, Merrill CB, Zibardi C, Tarzia G, Mor M, Duranti A, Tontini A, Rivara S, Piomelli D. PMID: 31579946; PMCID: PMC6842052.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    48. Waiting for the Entourage. Cannabis Cannabinoid Res. 2019; 4(3):137-138. Piomelli D. PMID: 31579831; PMCID: PMC6760171.
      View in: PubMed   Mentions: 4     Fields:    
    49. Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. Aging (Albany NY). 2019 08 29; 11(16):6336-6357. Granzotto A, Bomba M, Castelli V, Navarra R, Massetti N, d'Aurora M, Onofrj M, Cicalini I, Del Boccio P, Gatta V, Cimini A, Piomelli D, Sensi SL. PMID: 31467258; PMCID: PMC6738398.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    50. Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. Int J Mol Sci. 2019 Aug 17; 20(16). Vozella V, Realini N, Misto A, Piomelli D. PMID: 31426457; PMCID: PMC6720287.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    51. Serum Endocannabinoid Levels in Patients With End-Stage Renal Disease. J Endocr Soc. 2019 Oct 01; 3(10):1869-1880. Moradi H, Park C, Igarashi M, Streja E, Argueta DA, Soohoo M, Daglian J, You AS, Rhee CM, Kashyap ML, DiPatrizio NV, Vaziri ND, Kalantar-Zadeh K, Piomelli D. PMID: 31583368; PMCID: PMC6767629.
      View in: PubMed   Mentions: 6  
    52. Fast and Sensitive Quantification of Δ9-Tetrahydrocannabinol and Its Main Oxidative Metabolites by Liquid Chromatography/Tandem Mass Spectrometry. Cannabis Cannabinoid Res. 2019; 4(2):110-123. Vozella V, Zibardi C, Ahmed F, Piomelli D. PMID: 31236476; PMCID: PMC6590723.
      View in: PubMed   Mentions: 5     Fields:    
    53. Diurnal Profiles of N-Acylethanolamines in Goldfish Brain and Gastrointestinal Tract: Possible Role of Feeding. Front Neurosci. 2019; 13:450. Gómez-Boronat M, Isorna E, Armirotti A, Delgado MJ, Piomelli D, de Pedro N. PMID: 31133788; PMCID: PMC6514144.
      View in: PubMed   Mentions: 1  
    54. Regulatory Barriers to Research on Cannabis and Cannabinoids: A Proposed Path Forward. Cannabis Cannabinoid Res. 2019 Mar; 4(1):21-32. Piomelli D, Solomon R, Abrams D, Balla A, Grant I, Marcotte T, Yoder J. PMID: 35236017; PMCID: PMC8884193.
      View in: PubMed   Mentions: 1     Fields:    
    55. Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. Aging (Albany NY). 2019 01 08; 11(1):73-88. Vozella V, Basit A, Piras F, Realini N, Armirotti A, Bossù P, Assogna F, Sensi SL, Spalletta G, Piomelli D. PMID: 30620722; PMCID: PMC6339790.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    56. Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling. Cell Metab. 2019 01 08; 29(1):91-102.e5. Misto A, Provensi G, Vozella V, Passani MB, Piomelli D. PMID: 30318340.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    57. Molecular mechanism of activation of the immunoregulatory amidase NAAA. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):E10032-E10040. Gorelik A, Gebai A, Illes K, Piomelli D, Nagar B. PMID: 30301806; PMCID: PMC6205464.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    58. Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure. J Clin Endocrinol Metab. 2018 10 01; 103(10):3757-3766. Heinitz S, Basolo A, Piomelli D, Krakoff J, Piaggi P. PMID: 30113648; PMCID: PMC6179180.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    59. Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety. Psychopharmacology (Berl). 2018 Nov; 235(11):3211-3221. Danandeh A, Vozella V, Lim J, Oveisi F, Ramirez GL, Mears D, Wynn G, Piomelli D. PMID: 30251159.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    60. Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit. J Med Chem. 2018 09 13; 61(17):7902-7916. Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, Durante M, Sgambellone S, Masini E, Rivara S. PMID: 30126274.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cereb Cortex. 2018 07 01; 28(7):2253-2266. Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G. PMID: 28520937; PMCID: PMC5998949.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    62. Author Correction: Patch clamp-assisted single neuron lipidomics. Sci Rep. 2018 Apr 25; 8(1):6772. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. PMID: 29691427; PMCID: PMC5915401.
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    63. Cannabis and the Opioid Crisis. Cannabis Cannabinoid Res. 2018; 3(1):108-116. Piomelli D, Weiss S, Boyd G, Pacula RL, Cooper Z. PMID: 29789812; PMCID: PMC5931647.
      View in: PubMed   Mentions: 3     Fields:    
    64. Familial abnormalities of endocannabinoid signaling in schizophrenia. World J Biol Psychiatry. 2019 02; 20(2):117-125. Koethe D, Pahlisch F, Hellmich M, Rohleder C, Mueller JK, Meyer-Lindenberg A, Torrey EF, Piomelli D, Leweke FM. PMID: 29521179.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    65. Endocannabinoid System and Migraine Pain: An Update. Front Neurosci. 2018; 12:172. Greco R, Demartini C, Zanaboni AM, Piomelli D, Tassorelli C. PMID: 29615860; PMCID: PMC5867306.
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    66. Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage. J Clin Endocrinol Metab. 2018 03 01; 103(3):1077-1087. Heinitz S, Basolo A, Piaggi P, Piomelli D, Jumpertz von Schwartzenberg R, Krakoff J. PMID: 29300902; PMCID: PMC6276675.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    67. Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem. 2018 03 02; 293(9):3028-3038. Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ. PMID: 29326169; PMCID: PMC5836124.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    68. Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem Commun (Camb). 2017 Nov 28; 53(95):12814-12817. Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S, Mor M, Piomelli D. PMID: 29143042; PMCID: PMC5730275.
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    69. Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. Mol Psychiatry. 2018 08; 23(8):1798-1806. Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G. PMID: 29133950; PMCID: PMC5951717.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    70. The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of Allergic Dermatitis. J Invest Dermatol. 2018 03; 138(3):562-569. Sasso O, Summa M, Armirotti A, Pontis S, De Mei C, Piomelli D. PMID: 29054595.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    71. Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats. Psychopharmacology (Berl). 2018 01; 235(1):121-134. Schoch H, Huerta MY, Ruiz CM, Farrell MR, Jung KM, Huang JJ, Campbell RR, Piomelli D, Mahler SV. PMID: 29022083; PMCID: PMC5790819.
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    72. Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors. Br J Pharmacol. 2017 Nov; 174(21):3837-3847. Rock EM, Moreno-Sanz G, Limebeer CL, Petrie GN, Angelini R, Piomelli D, Parker LA. PMID: 28805944; PMCID: PMC5647182.
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    73. Expert Panel on Understanding Cannabis: Medicine, Society, Government. Cannabis Cannabinoid Res. 2017; 2(1):247-251. Kazan K, Piomelli D, Rohrabacher D, Ajax L. PMID: 29082321; PMCID: PMC5657088.
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    74. Age-dependent changes in nervonic acid-containing sphingolipids in mouse hippocampus. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec; 1862(12):1502-1511. Vozella V, Basit A, Misto A, Piomelli D. PMID: 28855145.
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    75. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb). 2017 Aug 22; 53(86):11810-11813. Petracca R, Romeo E, Baggelaar MP, Artola M, Pontis S, Ponzano S, Overkleeft HS, van der Stelt M, Piomelli D. PMID: 29035406.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine? Cephalalgia. 2018 05; 38(6):1138-1147. Greco R, Demartini C, Zanaboni AM, Berliocchi L, Piomelli D, Tassorelli C. PMID: 28816506.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    77. Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Sci Rep. 2017 08 07; 7(1):7411. Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, Pistello M, Mazzanti CM, Piomelli D. PMID: 28785021; PMCID: PMC5547127.
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    78. Patch clamp-assisted single neuron lipidomics. Sci Rep. 2017 07 13; 7(1):5318. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. PMID: 28706218; PMCID: PMC5509708.
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    79. Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex. Mol Psychiatry. 2018 04; 23(4):1040-1050. Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F. PMID: 28630452.
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    80. Specific skeletal muscle sphingolipid compounds in energy expenditure regulation and weight gain in Native Americans of Southwestern heritage. Int J Obes (Lond). 2017 10; 41(10):1585-1593. Heinitz S, Piaggi P, Vinales KL, Basolo A, Spranger J, Piomelli D, Krakoff J, Jumpertz von Schwartzenberg R. PMID: 28607453; PMCID: PMC5626585.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    81. Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware. Cannabis Cannabinoid Res. 2017; 2(1):123-132. Angelini R, Argueta DA, Piomelli D, DiPatrizio NV. PMID: 28861512; PMCID: PMC5510777.
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    82. A Guide to the National Academy of Science Report on Cannabis: An Exclusive Discussion with Panel Members. Cannabis Cannabinoid Res. 2017; 2(1):155-159. Piomelli D, Cooper Z, Abrams D, Grant I, Patel S. PMID: 28861515; PMCID: PMC5569624.
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    83. Endocannabinoid Signaling in the Control of Social Behavior. Trends Neurosci. 2017 07; 40(7):385-396. Wei D, Allsop S, Tye K, Piomelli D. PMID: 28554687; PMCID: PMC5699224.
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    84. Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities. Neuropharmacology. 2017 Sep 15; 124:3-12. Khurana L, Mackie K, Piomelli D, Kendall DA. PMID: 28527758; PMCID: PMC5540789.
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    85. TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nat Commun. 2017 05 10; 8:15292. Marrone MC, Morabito A, Giustizieri M, Chiurchiù V, Leuti A, Mattioli M, Marinelli S, Riganti L, Lombardi M, Murana E, Totaro A, Piomelli D, Ragozzino D, Oddi S, Maccarrone M, Verderio C, Marinelli S. PMID: 28489079; PMCID: PMC5436240.
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    86. Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels. J Alzheimers Dis. 2017; 60(3):769-781. den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT. PMID: 28035926.
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    87. Dysfunctional oleoylethanolamide signaling in a mouse model of Prader-Willi syndrome. Pharmacol Res. 2017 03; 117:75-81. Igarashi M, Narayanaswami V, Kimonis V, Galassetti PM, Oveisi F, Jung KM, Piomelli D. PMID: 28007570; PMCID: PMC5922435.
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    88. Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission. Brain Struct Funct. 2017 Jul; 222(5):2345-2357. Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I. PMID: 27905022; PMCID: PMC5504243.
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    89. Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase. J Vis Exp. 2016 11 23; (117). Romeo E, Pontis S, Ponzano S, Bonezzi F, Migliore M, Di Martino S, Summa M, Piomelli D. PMID: 27911411; PMCID: PMC5226263.
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    90. Progress in the development of β-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives. Eur J Med Chem. 2017 Jan 27; 126:561-575. Petracca R, Ponzano S, Bertozzi SM, Sasso O, Piomelli D, Bandiera T, Bertozzi F. PMID: 27915171.
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    91. Bile Acid Recognition by NAPE-PLD. ACS Chem Biol. 2016 10 21; 11(10):2908-2914. Margheritis E, Castellani B, Magotti P, Peruzzi S, Romeo E, Natali F, Mostarda S, Gioiello A, Piomelli D, Garau G. PMID: 27571266; PMCID: PMC5074845.
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    92. Increased Renal 2-Arachidonoylglycerol Level Is Associated with Improved Renal Function in a Mouse Model of Acute Kidney Injury. Cannabis Cannabinoid Res. 2016; 1(1):218-228. Moradi H, Oveisi F, Khanifar E, Moreno-Sanz G, Vaziri ND, Piomelli D. PMID: 28861493; PMCID: PMC5531066.
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    93. A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. eNeuro. 2016 Jul-Aug; 3(4). Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G. PMID: 27517090; PMCID: PMC4976302.
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    94. Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Sci Rep. 2016 08 08; 6:31046. Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, Jung KM, Piomelli D, Mor M. PMID: 27499063; PMCID: PMC4976315.
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    95. Endogenous N-acyl taurines regulate skin wound healing. Proc Natl Acad Sci U S A. 2016 07 26; 113(30):E4397-406. Sasso O, Pontis S, Armirotti A, Cardinali G, Kovacs D, Migliore M, Summa M, Moreno-Sanz G, Picardo M, Piomelli D. PMID: 27412859; PMCID: PMC4968764.
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    96. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 09 05; 55(37):11193-11197. Migliore M, Pontis S, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, Garcia-Guzman M, Heim R, Scarpelli R, Piomelli D. PMID: 27404798; PMCID: PMC5009002.
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    97. Absolute nutrient concentration measurements in cell culture media: (1)H q-NMR spectra and data to compare the efficiency of pH-controlled protein precipitation versus CPMG or post-processing filtering approaches. Data Brief. 2016 Sep; 8:387-93. Goldoni L, Beringhelli T, Rocchia W, Realini N, Piomelli D. PMID: 27331118; PMCID: PMC4909824.
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    98. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 03 24; 59(6):2612-32. Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S. PMID: 26888301.
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    99. A simple and accurate protocol for absolute polar metabolite quantification in cell cultures using quantitative nuclear magnetic resonance. Anal Biochem. 2016 May 15; 501:26-34. Goldoni L, Beringhelli T, Rocchia W, Realini N, Piomelli D. PMID: 26898303.
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    100. Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR:LA-cp rat. J Lipid Res. 2016 Apr; 57(4):638-49. Jacome-Sosa M, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field CJ, Igarashi M, Piomelli D, Banni S, Proctor SD. PMID: 26891736; PMCID: PMC4808772.
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    101. A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. Psychopharmacology (Berl). 2016 05; 233(10):1911-9. Wei D, Lee D, Li D, Daglian J, Jung KM, Piomelli D. PMID: 26873082; PMCID: PMC5118226.
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    102. Ion mobility mass spectrometry enhances low-abundance species detection in untargeted lipidomics. Metabolomics. 2016; 12:50. Basit A, Pontis S, Piomelli D, Armirotti A. PMID: 26900387; PMCID: PMC4744830.
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    103. Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism. 2016 07; 65(7):987-97. Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH. PMID: 27282869.
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    104. Enhancement of Anandamide-Mediated Endocannabinoid Signaling Corrects Autism-Related Social Impairment. Cannabis Cannabinoid Res. 2016; 1(1):81-89. Wei D, Dinh D, Lee D, Li D, Anguren A, Moreno-Sanz G, Gall CM, Piomelli D. PMID: 28861483; PMCID: PMC5549436.
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    105. Medicinal Cannabis in California: An Interview with Igor Grant, MD. Cannabis Cannabinoid Res. 2016; 1(1):78-80. Piomelli D, Grant I. PMID: 28861482; PMCID: PMC5576609.
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    106. Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. Eur J Med Chem. 2016 Mar 23; 111:138-59. Nuzzi A, Fiasella A, Ortega JA, Pagliuca C, Ponzano S, Pizzirani D, Bertozzi SM, Ottonello G, Tarozzo G, Reggiani A, Bandiera T, Bertozzi F, Piomelli D. PMID: 26866968.
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    107. An Important Role for N-Acylethanolamine Acid Amidase in the Complete Freund's Adjuvant Rat Model of Arthritis. J Pharmacol Exp Ther. 2016 Mar; 356(3):656-63. Bonezzi FT, Sasso O, Pontis S, Realini N, Romeo E, Ponzano S, Nuzzi A, Fiasella A, Bertozzi F, Piomelli D. PMID: 26769918.
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    108. Introduction to Cannabis and Cannabinoid Research. Cannabis Cannabinoid Res. 2016; 1(1):1-2. Piomelli D. PMID: 28861473; PMCID: PMC5576637.
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    109. The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD. Cannabis Cannabinoid Res. 2016; 1(1):44-46. Piomelli D, Russo EB. PMID: 28861479; PMCID: PMC5576603.
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    110. Legal or Illegal, Cannabis Is Still Addictive. Cannabis Cannabinoid Res. 2016; 1(1):47-53. Piomelli D, Haney M, Budney AJ, Piazza PV. PMID: 28861480; PMCID: PMC5576604.
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    111. Assay of Monoacylglycerol Lipase Activity. Methods Mol Biol. 2016; 1412:157-68. Jung KM, Piomelli D. PMID: 27245902.
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    112. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. Eur J Med Chem. 2016 Feb 15; 109:216-37. Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R. PMID: 26774927; PMCID: PMC4752335.
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    113. Fluorine nuclear magnetic resonance-based assay in living mammalian cells. Anal Biochem. 2016 Feb 15; 495:52-9. Veronesi M, Giacomina F, Romeo E, Castellani B, Ottonello G, Lambruschini C, Garau G, Scarpelli R, Bandiera T, Piomelli D, Dalvit C. PMID: 26686030.
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    114. P007. Inhibition of monoacylglycerol lipase activity modulates the activation of brain structures relevant for migraine pathogenesis. J Headache Pain. 2015 Dec; 16(Suppl 1):A165. Greco R, Bandiera T, Mangione AS, Demartini C, Nappi G, Sandrini G, Piomelli D, Tassorelli C. PMID: 28132223; PMCID: PMC4759149.
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    115. Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. J Med Chem. 2015 Dec 10; 58(23):9258-72. Bach A, Pizzirani D, Realini N, Vozella V, Russo D, Penna I, Melzig L, Scarpelli R, Piomelli D. PMID: 26560855.
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    116. Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation. Crit Rev Biochem Mol Biol. 2016; 51(1):7-14. Pontis S, Ribeiro A, Sasso O, Piomelli D. PMID: 26585314.
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    117. Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. Psychopharmacology (Berl). 2016 05; 233(10):1879-88. Panlilio LV, Thorndike EB, Nikas SP, Alapafuja SO, Bandiera T, Cravatt BF, Makriyannis A, Piomelli D, Goldberg SR, Justinova Z. PMID: 26558620; PMCID: PMC4846548.
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    118. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016 Jan 29; 291(5):2422-34. Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D. PMID: 26553872; PMCID: PMC4732224.
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    119. Endocannabinoid signaling mediates oxytocin-driven social reward. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14084-9. Wei D, Lee D, Cox CD, Karsten CA, Peñagarikano O, Geschwind DH, Gall CM, Piomelli D. PMID: 26504214; PMCID: PMC4653148.
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    120. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. ChemMedChem. 2016 06 20; 11(12):1242-51. Scarpelli R, Sasso O, Piomelli D. PMID: 26486424; PMCID: PMC4840092.
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    121. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. Neuropsychopharmacology. 2016 Apr; 41(5):1329-39. Lim J, Igarashi M, Jung KM, Butini S, Campiani G, Piomelli D. PMID: 26361059; PMCID: PMC4793117.
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    122. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R805-13. DiPatrizio NV, Igarashi M, Narayanaswami V, Murray C, Gancayco J, Russell A, Jung KM, Piomelli D. PMID: 26290104; PMCID: PMC4666947.
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    123. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015; 10(8):e0135113. Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. PMID: 26263173; PMCID: PMC4532501.
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    124. Monoglyceride lipase: Structure and inhibitors. Chem Phys Lipids. 2016 May; 197:13-24. Scalvini L, Piomelli D, Mor M. PMID: 26216043; PMCID: PMC4728057.
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    125. Activity-Based Probe for N-Acylethanolamine Acid Amidase. ACS Chem Biol. 2015 Sep 18; 10(9):2057-2064. Romeo E, Ponzano S, Armirotti A, Summa M, Bertozzi F, Garau G, Bandiera T, Piomelli D. PMID: 26102511; PMCID: PMC4575644.
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    126. Role of the satiety factor oleoylethanolamide in alcoholism. Addict Biol. 2016 07; 21(4):859-72. Bilbao A, Serrano A, Cippitelli A, Pavón FJ, Giuffrida A, Suárez J, García-Marchena N, Baixeras E, Gómez de Heras R, Orio L, Alén F, Ciccocioppo R, Cravatt BF, Parsons LH, Piomelli D, Rodríguez de Fonseca F. PMID: 26037332; PMCID: PMC4668242.
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    127. Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents. Biochim Biophys Acta. 2015 Sep; 1851(9):1218-26. Igarashi M, DiPatrizio NV, Narayanaswami V, Piomelli D. PMID: 26024927; PMCID: PMC4516666.
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    128. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chem Biol. 2015 May 21; 22(5):619-28. Dotsey EY, Jung KM, Basit A, Wei D, Daglian J, Vacondio F, Armirotti A, Mor M, Piomelli D. PMID: 26000748; PMCID: PMC4459529.
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    129. Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. J Physiol. 2015 Jun 01; 593(11):2527-45. Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y. PMID: 25728242; PMCID: PMC4461413.
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    130. A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. ACS Chem Biol. 2015 Aug 21; 10(8):1838-46. Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. PMID: 25874594; PMCID: PMC4546552.
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    131. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res. 2015 Jul; 97:7-15. Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. PMID: 25882247; PMCID: PMC4464910.
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    132. Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse. Neuropsychopharmacology. 2015 Aug; 40(9):2185-97. Justinova Z, Panlilio LV, Moreno-Sanz G, Redhi GH, Auber A, Secci ME, Mascia P, Bandiera T, Armirotti A, Bertorelli R, Chefer SI, Barnes C, Yasar S, Piomelli D, Goldberg SR. PMID: 25754762; PMCID: PMC4613608.
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    133. Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage. FASEB J. 2015 Jun; 29(6):2616-27. Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D. PMID: 25757568; PMCID: PMC4447230.
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    134. Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS. Anal Bioanal Chem. 2015 Jul; 407(17):5189-98. Basit A, Piomelli D, Armirotti A. PMID: 25749796; PMCID: PMC4471391.
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    135. Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. Structure. 2015 Mar 03; 23(3):598-604. Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G. PMID: 25684574; PMCID: PMC4351732.
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    136. Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis. PLoS One. 2015; 10(2):e0116961. Astarita G, Avanesian A, Grimaldi B, Realini N, Justinova Z, Panlilio LV, Basit A, Goldberg SR, Piomelli D. PMID: 25671639; PMCID: PMC4324822.
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    137. Intestinal lipid-derived signals that sense dietary fat. J Clin Invest. 2015 Mar 02; 125(3):891-8. DiPatrizio NV, Piomelli D. PMID: 25642767; PMCID: PMC4362267.
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    138. Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine. Cephalalgia. 2015 Oct; 35(12):1065-76. Greco R, Bandiera T, Mangione AS, Demartini C, Siani F, Nappi G, Sandrini G, Guijarro A, Armirotti A, Piomelli D, Tassorelli C. PMID: 25608877.
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    139. Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem. 2014 Dec 11; 57(23):10101-11. Ponzano S, Berteotti A, Petracca R, Vitale R, Mengatto L, Bandiera T, Cavalli A, Piomelli D, Bertozzi F, Bottegoni G. PMID: 25380517.
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    140. Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angew Chem Int Ed Engl. 2015 Jan 07; 54(2):485-9. Pizzirani D, Bach A, Realini N, Armirotti A, Mengatto L, Bauer I, Girotto S, Pagliuca C, De Vivo M, Summa M, Ribeiro A, Piomelli D. PMID: 25395373; PMCID: PMC4502975.
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    141. A lipid gate for the peripheral control of pain. J Neurosci. 2014 Nov 12; 34(46):15184-91. Piomelli D, Hohmann AG, Seybold V, Hammock BD. PMID: 25392487; PMCID: PMC4228127.
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    142. O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors. ChemMedChem. 2015 Feb; 10(2):380-95. Colombano G, Albani C, Ottonello G, Ribeiro A, Scarpelli R, Tarozzo G, Daglian J, Jung KM, Piomelli D, Bandiera T. PMID: 25338703; PMCID: PMC4384654.
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    143. Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain. Pharmacol Res. 2014 Sep; 87:87-93. Moreno-Sanz G, Barrera B, Armirotti A, Bertozzi SM, Scarpelli R, Bandiera T, Prieto JG, Duranti A, Tarzia G, Merino G, Piomelli D. PMID: 24993496; PMCID: PMC4134960.
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    144. Role of oleoylethanolamide as a feeding regulator in goldfish. J Exp Biol. 2014 Aug 01; 217(Pt 15):2761-9. Tinoco AB, Armirotti A, Isorna E, Delgado MJ, Piomelli D, de Pedro N. PMID: 24855680.
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    145. Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase. Chem Commun (Camb). 2014 May 18; 50(38):4904-7. De Simone A, Ruda GF, Albani C, Tarozzo G, Bandiera T, Piomelli D, Cavalli A, Bottegoni G. PMID: 24691497; PMCID: PMC4038168.
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    146. 3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration. ChemMedChem. 2014 Jul; 9(7):1602-14. Fiasella A, Nuzzi A, Summa M, Armirotti A, Tarozzo G, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. PMID: 24828120; PMCID: PMC4224963.
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    147. Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology. 2014 Oct; 39(11):2519-28. Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A. PMID: 24820537; PMCID: PMC4207337.
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    148. Advances in the discovery of N-acylethanolamine acid amidase inhibitors. Pharmacol Res. 2014 Aug; 86:11-7. Bandiera T, Ponzano S, Piomelli D. PMID: 24798679; PMCID: PMC4117721.
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    149. A mighty (ochondrial) fight? Mol Metab. 2014 Jul; 3(4):345-6. Piomelli D. PMID: 24944892; PMCID: PMC4060220.
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    150. Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia. Anal Biochem. 2014 Jun 15; 455:48-54. Armirotti A, Basit A, Realini N, Caltagirone C, Bossù P, Spalletta G, Piomelli D. PMID: 24708938.
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    151. Peripheral gating of pain signals by endogenous lipid mediators. Nat Neurosci. 2014 Feb; 17(2):164-74. Piomelli D, Sasso O. PMID: 24473264; PMCID: PMC4020413.
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    152. A discount on cannabinoids. Biol Psychiatry. 2014 Mar 15; 75(6):432-4. Piomelli D. PMID: 24560432.
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    153. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. J Biol Chem. 2014 Feb 28; 289(9):6091-7. Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. PMID: 24425865; PMCID: PMC3937675.
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    154. Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors. ChemMedChem. 2014 Feb; 9(2):323-36. Vitale R, Ottonello G, Petracca R, Bertozzi SM, Ponzano S, Armirotti A, Berteotti A, Dionisi M, Cavalli A, Piomelli D, Bandiera T, Bertozzi F. PMID: 24403170.
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    155. Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats. Psychosom Med. 2014 Jan; 76(1):20-28. Holman EA, Guijarro A, Lim J, Piomelli D. PMID: 24367128; PMCID: PMC3988664.
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    156. Fluorine NMR-based screening on cell membrane extracts. ChemMedChem. 2014 Feb; 9(2):286-9. Veronesi M, Romeo E, Lambruschini C, Piomelli D, Bandiera T, Scarpelli R, Garau G, Dalvit C. PMID: 24339446.
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    157. A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity. ACS Chem Biol. 2014 Feb 21; 9(2):398-404. Iorio M, Sasso O, Maffioli SI, Bertorelli R, Monciardini P, Sosio M, Bonezzi F, Summa M, Brunati C, Bordoni R, Corti G, Tarozzo G, Piomelli D, Reggiani A, Donadio S. PMID: 24191663.
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    158. Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus). Br J Pharmacol. 2013 Nov; 170(5):1130-6. O'Brien LD, Limebeer CL, Rock EM, Bottegoni G, Piomelli D, Parker LA. PMID: 23991698; PMCID: PMC3949659.
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    159. Brown adipose tissue quantification in human neonates using water-fat separated MRI. PLoS One. 2013; 8(10):e77907. Rasmussen JM, Entringer S, Nguyen A, van Erp TG, Burns J, Guijarro A, Oveisi F, Swanson JM, Piomelli D, Wadhwa PD, Buss C, Potkin SG. PMID: 24205024; PMCID: PMC3813555.
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    160. Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease. Hum Mol Genet. 2014 Mar 01; 23(5):1333-44. Llewellyn KJ, Nalbandian A, Jung KM, Nguyen C, Avanesian A, Mozaffar T, Piomelli D, Kimonis VE. PMID: 24158850; PMCID: PMC3919004.
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    161. Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem. 2013 Sep 12; 56(17):6917-34. Ponzano S, Bertozzi F, Mengatto L, Dionisi M, Armirotti A, Romeo E, Berteotti A, Fiorelli C, Tarozzo G, Reggiani A, Duranti A, Tarzia G, Mor M, Cavalli A, Piomelli D, Bandiera T. PMID: 23991897.
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    162. More surprises lying ahead. The endocannabinoids keep us guessing. Neuropharmacology. 2014 Jan; 76 Pt B:228-34. Piomelli D. PMID: 23954677; PMCID: PMC3855347.
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    163. Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem. 2013 Sep 02; 14(13):1611-9. Lambruschini C, Veronesi M, Romeo E, Garau G, Bandiera T, Piomelli D, Scarpelli R, Dalvit C. PMID: 23918626.
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    164. Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. J Med Chem. 2013 Jul 25; 56(14):5917-30. Moreno-Sanz G, Duranti A, Melzig L, Fiorelli C, Ruda GF, Colombano G, Mestichelli P, Sanchini S, Tontini A, Mor M, Bandiera T, Scarpelli R, Tarzia G, Piomelli D. PMID: 23822179; PMCID: PMC4062305.
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    165. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry. 2013 Sep; 18(9):1034-40. Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. PMID: 23670490; PMCID: PMC3752332.
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    166. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem. 2013 May 09; 56(9):3518-30. Pizzirani D, Pagliuca C, Realini N, Branduardi D, Bottegoni G, Mor M, Bertozzi F, Scarpelli R, Piomelli D, Bandiera T. PMID: 23614460.
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    167. A fatty gut feeling. Trends Endocrinol Metab. 2013 Jul; 24(7):332-41. Piomelli D. PMID: 23567058; PMCID: PMC3778443.
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    168. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors. J Med Chem. 2013 Mar 28; 56(6):2500-12. Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M. PMID: 23425199; PMCID: PMC3724458.
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    169. Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. FASEB J. 2013 Jun; 27(6):2513-20. DiPatrizio NV, Joslin A, Jung KM, Piomelli D. PMID: 23463697; PMCID: PMC3659363.
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    170. Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease. PLoS One. 2013; 8(2):e56870. Capurro V, Busquet P, Lopes JP, Bertorelli R, Tarozzo G, Bolognesi ML, Piomelli D, Reggiani A, Cavalli A. PMID: 23441223; PMCID: PMC3575497.
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    171. Wagging the Tail: Essential Role of Substrate Flexibility in FAAH Catalysis. J Chem Theory Comput. 2013 Feb 12; 9(2):1202-13. Palermo G, Campomanes P, Neri M, Piomelli D, Cavalli A, Rothlisberger U, De Vivo M. PMID: 26588763.
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    172. Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity. Brain Behav. 2013 Mar; 3(2):67-74. Lopes JP, Tarozzo G, Reggiani A, Piomelli D, Cavalli A. PMID: 23532860; PMCID: PMC3607148.
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    173. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep. 2013; 3:1035. Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D. PMID: 23301156; PMCID: PMC3539145.
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    174. A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. J Am Chem Soc. 2013 Jan 09; 135(1):22-5. Bertolacci L, Romeo E, Veronesi M, Magotti P, Albani C, Dionisi M, Lambruschini C, Scarpelli R, Cavalli A, De Vivo M, Piomelli D, Garau G. PMID: 23240907; PMCID: PMC3562592.
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    175. Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. Br J Pharmacol. 2012 Dec; 167(8):1620-8. Moreno-Sanz G, Sasso O, Guijarro A, Oluyemi O, Bertorelli R, Reggiani A, Piomelli D. PMID: 22774772; PMCID: PMC3525865.
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    176. Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice. J Pharmacol Sci. 2012; 120(4):305-9. Busquet P, Capurro V, Cavalli A, Piomelli D, Reggiani A, Bertorelli R. PMID: 23149577.
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    177. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar; 154(3):350-360. Sasso O, Moreno-Sanz G, Martucci C, Realini N, Dionisi M, Mengatto L, Duranti A, Tarozzo G, Tarzia G, Mor M, Bertorelli R, Reggiani A, Piomelli D. PMID: 23218523; PMCID: PMC3723234.
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    178. Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. J Med Chem. 2012 Nov 26; 55(22):9708-21. Simoni E, Daniele S, Bottegoni G, Pizzirani D, Trincavelli ML, Goldoni L, Tarozzo G, Reggiani A, Martini C, Piomelli D, Melchiorre C, Rosini M, Cavalli A. PMID: 23033965.
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    179. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25; 55(20):8807-26. Favia AD, Habrant D, Scarpelli R, Migliore M, Albani C, Bertozzi SM, Dionisi M, Tarozzo G, Piomelli D, Cavalli A, De Vivo M. PMID: 23043222; PMCID: PMC3764917.
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    180. Peroxisome proliferator-activated receptor α mediates acute effects of palmitoylethanolamide on sensory neurons. J Neurosci. 2012 Sep 12; 32(37):12735-43. Khasabova IA, Xiong Y, Coicou LG, Piomelli D, Seybold V. PMID: 22972997; PMCID: PMC3462371.
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    181. Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism. PLoS One. 2012; 7(7):e41503. Jumpertz R, Guijarro A, Pratley RE, Mason CC, Piomelli D, Krakoff J. PMID: 22911803; PMCID: PMC3404019.
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    182. Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatr Res. 2012 Oct; 72(4):400-6. Carloni S, Alonso-Alconada D, Girelli S, Duranti A, Tontini A, Piomelli D, Hilario E, Alvarez A, Balduini W. PMID: 22821058.
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    183. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 2012 Jul 11; 32(28):9457-68. Gregg LC, Jung KM, Spradley JM, Nyilas R, Suplita RL, Zimmer A, Watanabe M, Mackie K, Katona I, Piomelli D, Hohmann AG. PMID: 22787031; PMCID: PMC3652685.
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    184. Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates. Am J Physiol Endocrinol Metab. 2012 Sep 01; 303(5):E624-34. Vaidyanathan V, Bastarrachea RA, Higgins PB, Voruganti VS, Kamath S, DiPatrizio NV, Piomelli D, Comuzzie AG, Parks EJ. PMID: 22761159; PMCID: PMC3468508.
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    185. The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends Neurosci. 2012 Jul; 35(7):403-11. DiPatrizio NV, Piomelli D. PMID: 22622030; PMCID: PMC3744874.
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    186. N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. J Med Chem. 2012 May 24; 55(10):4824-36. Duranti A, Tontini A, Antonietti F, Vacondio F, Fioni A, Silva C, Lodola A, Rivara S, Solorzano C, Piomelli D, Tarzia G, Mor M. PMID: 22515328.
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    187. β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine. ACS Med Chem Lett. 2012 May 10; 3(5):422-6. Armirotti A, Romeo E, Ponzano S, Mengatto L, Dionisi M, Karacsonyi C, Bertozzi F, Garau G, Tarozzo G, Reggiani A, Bandiera T, Tarzia G, Mor M, Piomelli D. PMID: 24900487; PMCID: PMC4025845.
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    188. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2012 Mar 20; 2:e94. Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. PMID: 22832859; PMCID: PMC3316151.
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    189. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metab. 2012 Mar 07; 15(3):299-310. Jung KM, Clapper JR, Fu J, D'Agostino G, Guijarro A, Thongkham D, Avanesian A, Astarita G, DiPatrizio NV, Frontini A, Cinti S, Diano S, Piomelli D. PMID: 22405068; PMCID: PMC3729112.
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    190. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacol Res. 2012 May; 65(5):553-63. Sasso O, Bertorelli R, Bandiera T, Scarpelli R, Colombano G, Armirotti A, Moreno-Sanz G, Reggiani A, Piomelli D. PMID: 22420940; PMCID: PMC3738192.
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    191. A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. PLoS One. 2012; 7(2):e32397. Lodola A, Branduardi D, De Vivo M, Capoferri L, Mor M, Piomelli D, Cavalli A. PMID: 22389698; PMCID: PMC3289653.
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    192. Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. J Lipid Res. 2012 Apr; 53(4):744-54. Newberry EP, Kennedy SM, Xie Y, Luo J, Crooke RM, Graham MJ, Fu J, Piomelli D, Davidson NO. PMID: 22327204; PMCID: PMC3307651.
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    193. Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Adv Nutr. 2012 Jan; 3(1):60-8. Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN. PMID: 22332103; PMCID: PMC3262616.
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    194. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun. 2012; 3:1080. Jung KM, Sepers M, Henstridge CM, Lassalle O, Neuhofer D, Martin H, Ginger M, Frick A, DiPatrizio NV, Mackie K, Katona I, Piomelli D, Manzoni OJ. PMID: 23011134; PMCID: PMC3657999.
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    195. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012 Jan 27; 202:326-33. Snigdha S, Astarita G, Piomelli D, Cotman CW. PMID: 22183056; PMCID: PMC3447971.
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    196. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. PLoS One. 2011; 6(11):e28142. Cippitelli A, Astarita G, Duranti A, Caprioli G, Ubaldi M, Stopponi S, Kallupi M, Sagratini G, Rodrìguez de Fonseca F, Piomelli D, Ciccocioppo R. PMID: 22140525; PMCID: PMC3227620.
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    197. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci. 2011 Nov 20; 15(1):64-9. Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. PMID: 22101642; PMCID: PMC3245783.
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    198. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 22046234; PMCID: PMC3202527.
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    199. A thickening network of lipids. Pain. 2012 Jan; 153(1):3-4. Piomelli D. PMID: 22019134.
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    200. Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One. 2011; 6(9):e24652. Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW. PMID: 21931796; PMCID: PMC3172245.
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    201. Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. J Med Chem. 2011 Oct 13; 54(19):6612-23. Palermo G, Branduardi D, Masetti M, Lodola A, Mor M, Piomelli D, Cavalli A, De Vivo M. PMID: 21830831; PMCID: PMC3774108.
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    202. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Br J Pharmacol. 2011 Aug; 163(7):1464-78. Guindon J, Guijarro A, Piomelli D, Hohmann AG. PMID: 21198549; PMCID: PMC3165956.
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    203. Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability. Eur J Med Chem. 2011 Sep; 46(9):4466-73. Vacondio F, Silva C, Lodola A, Carmi C, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Tarzia G, Mor M. PMID: 21820769; PMCID: PMC3714604.
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    204. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011 Sep 09; 286(36):31532-41. Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN. PMID: 21757729; PMCID: PMC3173121.
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    205. The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacol Res. 2011 Oct; 64(4):359-63. Moreno-Sanz G, Barrera B, Guijarro A, d'Elia I, Otero JA, Alvarez AI, Bandiera T, Merino G, Piomelli D. PMID: 21767647; PMCID: PMC3729352.
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    206. Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12904-8. DiPatrizio NV, Astarita G, Schwartz G, Li X, Piomelli D. PMID: 21730161; PMCID: PMC3150876.
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    207. Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. Prostaglandins Leukot Essent Fatty Acids. 2011 Nov; 85(5):197-203. Astarita G, Piomelli D. PMID: 21543199; PMCID: PMC3161165.
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    208. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 21546126; PMCID: PMC3154439.
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    209. Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms. Mol Pharmacol. 2011 Jul; 80(1):60-7. Jung KM, Astarita G, Thongkham D, Piomelli D. PMID: 21493725; PMCID: PMC3127538.
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    210. Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. J Neurosci. 2011 Apr 13; 31(15):5730-6. Fu J, Dipatrizio NV, Guijarro A, Schwartz GJ, Li X, Gaetani S, Astarita G, Piomelli D. PMID: 21490214; PMCID: PMC3084524.
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    211. The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunol. 2011 Sep; 4(5):574-83. Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E, Guerci M, Piomelli D, Pender SL, MacDonald TT, Maccarrone M, Corazza GR. PMID: 21471961.
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    212. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry. 2011 Apr 01; 69(7):633-41. Mascia P, Pistis M, Justinova Z, Panlilio LV, Luchicchi A, Lecca S, Scherma M, Fratta W, Fadda P, Barnes C, Redhi GH, Yasar S, Le Foll B, Tanda G, Piomelli D, Goldberg SR. PMID: 20801430; PMCID: PMC2994947.
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    213. Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients. J Lipid Res. 2011 May; 52(5):1011-22. Ollero M, Astarita G, Guerrera IC, Sermet-Gaudelus I, Trudel S, Piomelli D, Edelman A. PMID: 21335323; PMCID: PMC3073467.
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    214. Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. Chem Commun (Camb). 2011 Mar 07; 47(9):2517-9. Lodola A, Capoferri L, Rivara S, Chudyk E, Sirirak J, Dyguda-Kazimierowicz E, Andrzej Sokalski W, Mileni M, Tarzia G, Piomelli D, Mor M, Mulholland AJ. PMID: 21240393.
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    215. Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Mol Pharmacol. 2011 Apr; 79(4):786-92. Zhu C, Solorzano C, Sahar S, Realini N, Fung E, Sassone-Corsi P, Piomelli D. PMID: 21233218; PMCID: PMC3063731.
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    216. Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity. Cell Metab. 2011 Jan 05; 13(1):105-13. Wang H, Astarita G, Taussig MD, Bharadwaj KG, DiPatrizio NV, Nave KA, Piomelli D, Goldberg IJ, Eckel RH. PMID: 21195353; PMCID: PMC3034302.
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    217. New lipidomic approaches in cystic fibrosis. Methods Mol Biol. 2011; 742:265-78. Ollero M, Guerrera IC, Astarita G, Piomelli D, Edelman A. PMID: 21547738.
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    218. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. J Clin Endocrinol Metab. 2011 Mar; 96(3):787-91. Jumpertz R, Guijarro A, Pratley RE, Piomelli D, Krakoff J. PMID: 21177788; PMCID: PMC3047230.
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    219. PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab. 2010 Nov 03; 12(5):509-20. Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P. PMID: 21035761; PMCID: PMC4103168.
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    220. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology (Berl). 2011 Mar; 214(2):465-76. Cassano T, Gaetani S, Macheda T, Laconca L, Romano A, Morgese MG, Cimmino CS, Chiarotti F, Bambico FR, Gobbi G, Cuomo V, Piomelli D. PMID: 21042794; PMCID: PMC3045513.
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    221. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience. 2011 Feb 03; 174:50-63. Ludányi A, Hu SS, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, Katona I. PMID: 21035522; PMCID: PMC3678284.
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    222. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nat Rev Neurosci. 2010 10; 11(10):718-26. Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, Block ML, Zecca L, Hong JS, Dantzer R, Kelley KW, Craig AD. PMID: 20852655; PMCID: PMC3395239.
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    223. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 2010 Oct; 13(10):1265-70. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D. PMID: 20852626; PMCID: PMC3260554.
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    224. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. PMID: 20838618; PMCID: PMC2935886.
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    225. Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. J Med Chem. 2010 Aug 12; 53(15):5770-81. Solorzano C, Antonietti F, Duranti A, Tontini A, Rivara S, Lodola A, Vacondio F, Tarzia G, Piomelli D, Mor M. PMID: 20604568; PMCID: PMC2932887.
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    226. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology. 2010 Sep; 35(10):2083-100. Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G. PMID: 20571484; PMCID: PMC3055302.
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    227. The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. J Neurosci. 2010 Jun 16; 30(24):8096-101. Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, Piomelli D. PMID: 20554860; PMCID: PMC2900249.
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    228. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. PLoS One. 2010 May 28; 5(5):e10891. Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. PMID: 20531936; PMCID: PMC2878341.
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    229. Pitfalls and solutions in assaying anandamide transport in cells. J Lipid Res. 2010 Aug; 51(8):2435-44. Oddi S, Fezza F, Catanzaro G, De Simone C, Pucci M, Piomelli D, Finazzi-Agrò A, Maccarrone M. PMID: 20447929; PMCID: PMC2903826.
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    230. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience. 2010 Jun 30; 168(2):371-86. Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG, Piomelli D. PMID: 20394803; PMCID: PMC2882942.
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    231. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Pharmacol Res. 2010 May; 61(5):419-29. Eisenstein SA, Clapper JR, Holmes PV, Piomelli D, Hohmann AG. PMID: 20044005; PMCID: PMC2867105.
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    232. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis. 2010; 22(1):135-50. Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. PMID: 20847439.
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    233. FAAH deficiency promotes energy storage and enhances the motivation for food. Int J Obes (Lond). 2010 Mar; 34(3):557-68. Touriño C, Oveisi F, Lockney J, Piomelli D, Maldonado R. PMID: 20029375; PMCID: PMC3709605.
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    234. Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20966-71. Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. PMID: 19926854; PMCID: PMC2791595.
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    235. A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. PLoS One. 2009 Nov 06; 4(11):e7735. Guerrera IC, Astarita G, Jais JP, Sands D, Nowakowska A, Colas J, Sermet-Gaudelus I, Schuerenberg M, Piomelli D, Edelman A, Ollero M. PMID: 19893743; PMCID: PMC2768907.
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    236. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol. 2009 Oct 30; 16(10):1045-52. King AR, Dotsey EY, Lodola A, Jung KM, Ghomian A, Qiu Y, Fu J, Mor M, Piomelli D. PMID: 19875078; PMCID: PMC3034734.
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    237. CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice. Pharmacol Res. 2010 Jan; 61(1):27-33. Guijarro A, Fu J, Astarita G, Piomelli D. PMID: 19778614; PMCID: PMC2846762.
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    238. A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo. ChemMedChem. 2009 Sep; 4(9):1505-13. Clapper JR, Vacondio F, King AR, Duranti A, Tontini A, Silva C, Sanchini S, Tarzia G, Mor M, Piomelli D. PMID: 19637155; PMCID: PMC3016090.
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    239. Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability. ChemMedChem. 2009 Sep; 4(9):1495-504. Vacondio F, Silva C, Lodola A, Fioni A, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Mor M, Tarzia G. PMID: 19554599; PMCID: PMC3517974.
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    240. A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors. Br J Pharmacol. 2009 Jul; 157(6):974-83. King AR, Lodola A, Carmi C, Fu J, Mor M, Piomelli D. PMID: 19486005; PMCID: PMC2737656.
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    241. Fat-induced satiety factor oleoylethanolamide enhances memory consolidation. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):8027-31. Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, Piomelli D. PMID: 19416833; PMCID: PMC2683095.
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    242. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. Eur J Pharmacol. 2009 Jun 24; 613(1-3):54-9. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Loverme J, Piomelli D, Meli R, Calignano A. PMID: 19386271.
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    243. An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. Psychopharmacology (Berl). 2009 Jul; 205(1):63-72. Mangieri RA, Hong KI, Piomelli D, Sinha R. PMID: 19343330; PMCID: PMC2715164.
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    244. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. Br J Psychiatry. 2009 Apr; 194(4):371-2. Koethe D, Giuffrida A, Schreiber D, Hellmich M, Schultze-Lutter F, Ruhrmann S, Klosterkötter J, Piomelli D, Leweke FM. PMID: 19336792.
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    245. The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity. J Mass Spectrom. 2009 Apr; 44(4):561-5. Valitutti G, Duranti A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. PMID: 19034887.
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    246. The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew). Physiol Behav. 2009 Apr 20; 97(1):121-4. Parker LA, Limebeer CL, Rock EM, Litt DL, Kwiatkowska M, Piomelli D. PMID: 19239915; PMCID: PMC3781595.
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    247. Responses to stress: from the periphery to the brain. Curr Opin Pharmacol. 2009 Feb; 9(1):1-2. Piomelli D. PMID: 19162545.
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    248. Lipidomic analysis of endocannabinoid metabolism in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15; 877(26):2755-67. Astarita G, Piomelli D. PMID: 19171504; PMCID: PMC2723187.
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    249. Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. J Neural Transm (Vienna). 2009 Mar; 116(3):301-5. Koethe D, Schreiber D, Giuffrida A, Mauss C, Faulhaber J, Heydenreich B, Hellmich M, Graf R, Klosterkötter J, Piomelli D, Leweke FM. PMID: 19137236; PMCID: PMC2757605.
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    250. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. Int Rev Neurobiol. 2009; 85:57-72. Gaetani S, Dipasquale P, Romano A, Righetti L, Cassano T, Piomelli D, Cuomo V. PMID: 19607961.
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    251. Targeted lipidomics as a tool to investigate endocannabinoid function. Int Rev Neurobiol. 2009; 85:35-55. Astarita G, Geaga J, Ahmed F, Piomelli D. PMID: 19607960.
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    252. Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry. Methods Mol Biol. 2009; 579:201-19. Astarita G, Ahmed F, Piomelli D. PMID: 19763477.
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    253. The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice. Neurogastroenterol Motil. 2009 Apr; 21(4):420-9. Cluny NL, Keenan CM, Lutz B, Piomelli D, Sharkey KA. PMID: 19140957.
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    254. Rapid pain modulation with nuclear receptor ligands. Brain Res Rev. 2009 Apr; 60(1):114-24. Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. PMID: 19162071; PMCID: PMC3695814.
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    255. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):639-43. LoVerme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N, Xu C, Tarzia G, Piomelli D. PMID: 19128970; PMCID: PMC3690177.
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    256. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1255-65. Duncan M, Thomas AD, Cluny NL, Patel A, Patel KD, Lutz B, Piomelli D, Alexander SP, Sharkey KA. PMID: 18948437.
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    257. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab. 2008 Oct; 8(4):281-288. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. PMID: 18840358; PMCID: PMC2572640.
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    258. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biol Psychiatry. 2008 Dec 01; 64(11):930-7. Justinova Z, Mangieri RA, Bortolato M, Chefer SI, Mukhin AG, Clapper JR, King AR, Redhi GH, Yasar S, Piomelli D, Goldberg SR. PMID: 18814866; PMCID: PMC2701259.
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    259. Role of endocannabinoids and their analogues in obesity and eating disorders. Eat Weight Disord. 2008 Sep; 13(3):e42-8. Gaetani S, Kaye WH, Cuomo V, Piomelli D. PMID: 19011363.
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    260. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. J Pharmacol Exp Ther. 2008 Nov; 327(2):482-90. Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinová Z, Mikics E, Haller J, Medalie J, Stroik J, Barnes C, Yasar S, Tanda G, Piomelli D, Fratta W, Goldberg SR. PMID: 18725543; PMCID: PMC2663803.
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    261. The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology. 2009; 56 Suppl 1:235-43. Clapper JR, Mangieri RA, Piomelli D. PMID: 18691603; PMCID: PMC2647947.
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    262. The element of surprise. Nat Med. 2008 Jul; 14(7):720-1. Piomelli D. PMID: 18607371.
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    263. An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology (Berl). 2008 Oct; 200(3):333-46. Moise AM, Eisenstein SA, Astarita G, Piomelli D, Hohmann AG. PMID: 18545985; PMCID: PMC2694060.
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    264. Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. J Med Chem. 2008 Jun 26; 51(12):3487-98. Mor M, Lodola A, Rivara S, Vacondio F, Duranti A, Tontini A, Sanchini S, Piersanti G, Clapper JR, King AR, Tarzia G, Piomelli D. PMID: 18507372; PMCID: PMC3744893.
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    265. Improvement of general symptoms in a chronic psychotic patient treated with finasteride: case report. Pharmacopsychiatry. 2008 May; 41(3):115-6. Koethe D, Bortolato M, Piomelli D, Leweke FM. PMID: 18484553.
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    266. Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. J Psychopharmacol. 2008 May; 22(3):262-9. Potvin S, Kouassi E, Lipp O, Bouchard RH, Roy MA, Demers MF, Gendron A, Astarita G, Piomelli D, Stip E. PMID: 18308802.
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    267. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. Psychopharmacology (Berl). 2008 Jul; 198(4):449-60. Cippitelli A, Cannella N, Braconi S, Duranti A, Tontini A, Bilbao A, Defonseca FR, Piomelli D, Ciccocioppo R. PMID: 18446329.
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    268. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am J Physiol Regul Integr Comp Physiol. 2008 Jul; 295(1):R45-50. Fu J, Kim J, Oveisi F, Astarita G, Piomelli D. PMID: 18434444; PMCID: PMC2494809.
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    269. The endocannabinoid system in brain reward processes. Br J Pharmacol. 2008 May; 154(2):369-83. Solinas M, Goldberg SR, Piomelli D. PMID: 18414385; PMCID: PMC2442437.
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    270. Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. J Pharmacol Exp Ther. 2008 Jul; 326(1):12-23. Genovese T, Esposito E, Mazzon E, Di Paola R, Meli R, Bramanti P, Piomelli D, Calignano A, Cuzzocrea S. PMID: 18367664.
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    271. Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors. J Mass Spectrom. 2007 Dec; 42(12):1624-7. Valitutti G, Duranti A, Lodola A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. PMID: 18085570.
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    273. The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat. Psychopharmacology (Berl). 2008 Feb; 196(3):389-95. Rock EM, Limebeer CL, Mechoulam R, Piomelli D, Parker LA. PMID: 17992520.
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    274. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors. Neuropharmacology. 2008 Mar; 54(3):521-9. La Rana G, Russo R, D'Agostino G, Sasso O, Raso GM, Iacono A, Meli R, Piomelli D, Calignano A. PMID: 18093621.
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    275. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. J Lipid Res. 2008 Jan; 49(1):48-57. Astarita G, Ahmed F, Piomelli D. PMID: 17957091.
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    276. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. Chem Commun (Camb). 2008 Jan 14; (2):214-6. Lodola A, Mor M, Rivara S, Christov C, Tarzia G, Piomelli D, Mulholland AJ. PMID: 18092091.
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    277. A neuroscientist's guide to lipidomics. Nat Rev Neurosci. 2007 Oct; 8(10):743-54. Piomelli D, Astarita G, Rapaka R. PMID: 17882252.
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    278. Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacol Res. 2007 Nov; 56(5):360-6. Mangieri RA, Piomelli D. PMID: 17945507; PMCID: PMC2104793.
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    279. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007 Sep; 97(9):887-94. Tarzia G, Antonietti F, Duranti A, Tontini A, Mor M, Rivara S, Traldi P, Astarita G, King A, Clapper JR, Piomelli D. PMID: 17970304.
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    280. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. 2008 Jan; 54(1):129-40. Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, Mikics E, Haller J, Yasar S, Tanda G, Goldberg SR. PMID: 17904589; PMCID: PMC2213536.
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    281. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry. 2007 Aug 21; 46(33):9578-85. Vila A, Rosengarth A, Piomelli D, Cravatt B, Marnett LJ. PMID: 17649977.
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    282. The anandamide transport inhibitor AM404 reduces ethanol self-administration. Eur J Neurosci. 2007 Jul; 26(2):476-86. Cippitelli A, Bilbao A, Gorriti MA, Navarro M, Massi M, Piomelli D, Ciccocioppo R, Rodríguez de Fonseca F. PMID: 17650118.
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    283. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol Pharmacol. 2007 Sep; 72(3):612-21. Jung KM, Astarita G, Zhu C, Wallace M, Mackie K, Piomelli D. PMID: 17584991.
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    284. Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. Schizophr Res. 2007 Aug; 94(1-3):29-36. Leweke FM, Giuffrida A, Koethe D, Schreiber D, Nolden BM, Kranaster L, Neatby MA, Schneider M, Gerth CW, Hellmich M, Klosterkötter J, Piomelli D. PMID: 17566707.
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    285. Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice. J Pharmacol Exp Ther. 2007 Sep; 322(3):1137-43. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Raso GM, Cuzzocrea S, Lo Verme J, Piomelli D, Meli R, Calignano A. PMID: 17565008.
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    286. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesth Analg. 2007 Jun; 104(6):1563-9, table of contents. Guindon J, LoVerme J, Piomelli D, Beaulieu P. PMID: 17513659.
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    287. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry. 2007 Nov 15; 62(10):1103-10. Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. PMID: 17511970.
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    288. Regulation of brain anandamide by acute administration of ethanol. Biochem J. 2007 May 15; 404(1):97-104. Ferrer B, Bermúdez-Silva FJ, Bilbao A, Alvarez-Jaimes L, Sanchez-Vera I, Giuffrida A, Serrano A, Baixeras E, Khaturia S, Navarro M, Parsons LH, Piomelli D, Rodríguez de Fonseca F. PMID: 17302558; PMCID: PMC1868843.
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    289. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. J Pharmacol Exp Ther. 2007 Jul; 322(1):236-42. Russo R, Loverme J, La Rana G, Compton TR, Parrott J, Duranti A, Tontini A, Mor M, Tarzia G, Calignano A, Piomelli D. PMID: 17412883.
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    290. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. Eur J Pharmacol. 2007 Jul 02; 566(1-3):117-9. Russo R, LoVerme J, La Rana G, D'Agostino G, Sasso O, Calignano A, Piomelli D. PMID: 17434479; PMCID: PMC1997313.
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    291. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. J Pharmacol Exp Ther. 2007 Apr; 321(1):370-80. Solinas M, Tanda G, Justinova Z, Wertheim CE, Yasar S, Piomelli D, Vadivel SK, Makriyannis A, Goldberg SR. PMID: 17210800.
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    292. Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. Anal Biochem. 2007 Feb 15; 361(2):162-8. Schreiber D, Harlfinger S, Nolden BM, Gerth CW, Jaehde U, Schömig E, Klosterkötter J, Giuffrida A, Astarita G, Piomelli D, Markus Leweke F. PMID: 17196922.
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    293. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem. 2007 Jan 12; 282(2):1518-28. Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D. PMID: 17121838; PMCID: PMC1764767.
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    294. Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat. Psychopharmacology (Berl). 2007 Feb; 190(2):135-43. Cross-Mellor SK, Ossenkopp KP, Piomelli D, Parker LA. PMID: 17111174.
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    295. Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase. Biophys J. 2007 Jan 15; 92(2):L20-2. Lodola A, Mor M, Zurek J, Tarzia G, Piomelli D, Harvey JN, Mulholland AJ. PMID: 17098788; PMCID: PMC1751413.
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    296. Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha. J Pharmacol Exp Ther. 2006 Dec; 319(3):1051-61. LoVerme J, Russo R, La Rana G, Fu J, Farthing J, Mattace-Raso G, Meli R, Hohmann A, Calignano A, Piomelli D. PMID: 16997973.
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    297. Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? Eur J Pharmacol. 2006 Nov 21; 550(1-3):68-77. Guindon J, LoVerme J, De Léan A, Piomelli D, Beaulieu P. PMID: 17027744.
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    298. Presence of depolarization-induced suppression of inhibition in a fraction of GABAergic synaptic connections in rat neocortical cultures. Neurosci Behav Physiol. 2006 Sep; 36(7):709-13. Storozhuk MV, Ivanova SY, Piomelli D. PMID: 16841150.
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    299. The cannabinoid receptor agonist WIN 55,212-2 attenuates the effects induced by quinolinic acid in the rat striatum. Neuropharmacology. 2006 Oct; 51(5):1004-12. Pintor A, Tebano MT, Martire A, Grieco R, Galluzzo M, Scattoni ML, Pèzzola A, Coccurello R, Felici F, Cuomo V, Piomelli D, Calamandrei G, Popoli P. PMID: 16895732.
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    300. The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacol Res. 2006 Nov; 54(5):341-4. Clapper JR, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. PMID: 16935521.
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    301. Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. J Biol Chem. 2006 Aug 11; 281(32):22815-8. LoVerme J, Guzmán M, Gaetani S, Piomelli D. PMID: 16785227.
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    302. Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci. 2006 May 24; 26(21):5628-37. Katona I, Urbán GM, Wallace M, Ledent C, Jung KM, Piomelli D, Mackie K, Freund TF. PMID: 16723519; PMCID: PMC1698282.
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    304. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 Dec; 31(12):2652-9. Bortolato M, Campolongo P, Mangieri RA, Scattoni ML, Frau R, Trezza V, La Rana G, Russo R, Calignano A, Gessa GL, Cuomo V, Piomelli D. PMID: 16541083.
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    305. Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]. J Pharmacol Exp Ther. 2006 Jun; 317(3):1365-71. La Rana G, Russo R, Campolongo P, Bortolato M, Mangieri RA, Cuomo V, Iacono A, Raso GM, Meli R, Piomelli D, Calignano A. PMID: 16510698.
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    306. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol. 2006 Feb; 147(3):281-8. Jayamanne A, Greenwood R, Mitchell VA, Aslan S, Piomelli D, Vaughan CW. PMID: 16331291; PMCID: PMC1751298.
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    307. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 2006; 12(1):21-38. Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D. PMID: 16834756; PMCID: PMC6741741.
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    308. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring. ChemMedChem. 2006 Jan; 1(1):130-9. Tarzia G, Duranti A, Gatti G, Piersanti G, Tontini A, Rivara S, Lodola A, Plazzi PV, Mor M, Kathuria S, Piomelli D. PMID: 16892344.
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    309. Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia. Neurosci Lett. 2006 Apr 24; 397(3):180-4. Connell K, Bolton N, Olsen D, Piomelli D, Hohmann AG. PMID: 16378681.
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    310. Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus). Am J Physiol Regul Integr Comp Physiol. 2006 May; 290(5):R1407-12. Astarita G, Rourke BC, Andersen JB, Fu J, Kim JH, Bennett AF, Hicks JW, Piomelli D. PMID: 16373434.
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    311. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18620-5. Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T, Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR, Cuomo V, Piomelli D. PMID: 16352709; PMCID: PMC1317988.
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    312. Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacology. 2006 Mar; 50(3):372-9. Suplita RL, Gutierrez T, Fegley D, Piomelli D, Hohmann AG. PMID: 16316669.
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    313. Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. Endocrinology. 2006 Feb; 147(2):827-34. Su HF, Samsamshariat A, Fu J, Shan YX, Chen YH, Piomelli D, Wang PH. PMID: 16269455.
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    314. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science. 2005 Oct 14; 310(5746):329-32. Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA. PMID: 16224028.
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    315. Presence of depolarization-induced suppression of inhibition in a fraction of gabaergic synaptic connections in rat neocortical cultures. Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 Sep-Oct; 55(5):581-5. Storozhuk MV, Ivanova SY, Piomelli D. PMID: 16316018.
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    316. The challenge of brain lipidomics. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):23-34. Piomelli D. PMID: 16099388.
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    317. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):223-34. Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. PMID: 16099407.
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    318. The search for the palmitoylethanolamide receptor. Life Sci. 2005 Aug 19; 77(14):1685-98. LoVerme J, La Rana G, Russo R, Calignano A, Piomelli D. PMID: 15963531.
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    320. A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. Exp Neurol. 2005 Aug; 194(2):355-62. Solbrig MV, Adrian R, Baratta J, Piomelli D, Giuffrida A. PMID: 16022863.
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    321. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol Pharmacol. 2005 Nov; 68(5):1196-202. Jung KM, Mangieri R, Stapleton C, Kim J, Fegley D, Wallace M, Mackie K, Piomelli D. PMID: 16051747.
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    323. The endocannabinoid system: a drug discovery perspective. Curr Opin Investig Drugs. 2005 Jul; 6(7):672-9. Piomelli D. PMID: 16044662.
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    326. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005 Jun; 48(8):1147-53. Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D. PMID: 15910890.
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    327. Regulation of food intake by oleoylethanolamide. Cell Mol Life Sci. 2005 Mar; 62(6):708-16. Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D. PMID: 15770421.
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    328. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. 2005 Apr; 313(1):352-8. Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. PMID: 15579492.
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    329. Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters. J Mass Spectrom. 2004 Dec; 39(12):1450-5. Basso E, Duranti A, Mor M, Piomelli D, Tontini A, Tarzia G, Traldi P. PMID: 15578755.
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    330. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology. 2004 Nov; 29(11):2108-14. Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, Faulhaber J, Klosterkötter J, Piomelli D. PMID: 15354183.
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    331. Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies. J Med Chem. 2004 Oct 07; 47(21):4998-5008. Mor M, Rivara S, Lodola A, Plazzi PV, Tarzia G, Duranti A, Tontini A, Piersanti G, Kathuria S, Piomelli D. PMID: 15456244.
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    332. The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol. 2005 Jan; 67(1):15-9. Lo Verme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D. PMID: 15465922.
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    333. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Mol Pharmacol. 2004 Nov; 66(5):1260-4. Dinh TP, Kathuria S, Piomelli D. PMID: 15272052.
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    334. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Eur J Neurosci. 2004 Jul; 20(2):441-58. Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F, Freund TF. PMID: 15233753.
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    335. Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: effects of low temperature and the transport inhibitor AM404. Eur J Neurosci. 2004 Jun; 19(11):2991-6. Hájos N, Kathuria S, Dinh T, Piomelli D, Freund TF. PMID: 15182306.
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    336. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8756-61. Fegley D, Kathuria S, Mercier R, Li C, Goutopoulos A, Makriyannis A, Piomelli D. PMID: 15138300; PMCID: PMC423268.
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    337. Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration. Pharmacol Res. 2004 May; 49(5):461-6. Oveisi F, Gaetani S, Eng KT, Piomelli D. PMID: 14998556.
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    339. The endogenous cannabinoid system and the treatment of marijuana dependence. Neuropharmacology. 2004; 47 Suppl 1:359-67. Piomelli D. PMID: 15464150.
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    340. THC: moderation during implantation. Nat Med. 2004 Jan; 10(1):19-20. Piomelli D. PMID: 14702623.
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    341. Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. Sleep. 2003 Dec 15; 26(8):943-7. Murillo-Rodriguez E, Blanco-Centurion C, Sanchez C, Piomelli D, Shiromani PJ. PMID: 14746372.
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    342. Exercise activates the endocannabinoid system. Neuroreport. 2003 Dec 02; 14(17):2209-11. Sparling PB, Giuffrida A, Piomelli D, Rosskopf L, Dietrich A. PMID: 14625449.
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    343. The molecular logic of endocannabinoid signalling. Nat Rev Neurosci. 2003 Nov; 4(11):873-84. Piomelli D. PMID: 14595399.
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    344. Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends Mol Med. 2003 Nov; 9(11):474-8. Gaetani S, Cuomo V, Piomelli D. PMID: 14604824.
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    347. Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. Eur J Neurosci. 2003 Sep; 18(6):1607-14. Ferrer B, Asbrock N, Kathuria S, Piomelli D, Giuffrida A. PMID: 14511339.
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    348. Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron. 2003 Aug 14; 39(4):599-611. Chen K, Ratzliff A, Hilgenberg L, Gulyás A, Freund TF, Smith M, Dinh TP, Piomelli D, Mackie K, Soltesz I. PMID: 12925275.
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    349. Role of endogenous cannabinoids in synaptic signaling. Physiol Rev. 2003 Jul; 83(3):1017-66. Freund TF, Katona I, Piomelli D. PMID: 12843414.
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    351. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology. 2003 Jul; 28(7):1311-6. Gaetani S, Oveisi F, Piomelli D. PMID: 12700681.
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    352. N-Acylethanolamines in human reproductive fluids. Chem Phys Lipids. 2002 Dec 31; 121(1-2):211-27. Schuel H, Burkman LJ, Lippes J, Crickard K, Forester E, Piomelli D, Giuffrida A. PMID: 12505702.
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    353. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids. 2002 Dec 31; 121(1-2):149-58. Dinh TP, Freund TF, Piomelli D. PMID: 12505697.
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    356. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci. 2002 Nov 01; 22(21):9612-7. Gómez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodríguez de Fonseca F. PMID: 12417686; PMCID: PMC6758016.
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    357. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. Stroke. 2002 Aug; 33(8):2112-4. Schäbitz WR, Giuffrida A, Berger C, Aschoff A, Schwaninger M, Schwab S, Piomelli D. PMID: 12154273.
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    360. Cannabinoid activity curtails cocaine craving. Nat Med. 2001 Oct; 7(10):1099-100. Piomelli D. PMID: 11590424.
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    367. Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature. 2000 Nov 02; 408(6808):96-101. Calignano A, Kátona I, Désarnaud F, Giuffrida A, La Rana G, Mackie K, Freund TF, Piomelli D. PMID: 11081515.
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    368. The endocannabinoid system: a physiological perspective on its role in psychomotor control. Chem Phys Lipids. 2000 Nov; 108(1-2):151-8. Giuffrida A, Piomelli D. PMID: 11106788.
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    371. Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. Neuroreport. 2000 Apr 27; 11(6):1231-5. Beltramo M, Piomelli D. PMID: 10817598.
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    373. Endogenous cannabinoid signaling and psychomotor disorders. Prostaglandins Other Lipid Mediat. 2000 Apr; 61(1-2):63-70. Giuffrida A, Désarnaud F, Piomelli D. PMID: 10785542.
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    374. Pot of gold for glioma therapy. Nat Med. 2000 Mar; 6(3):255-6. Piomelli D. PMID: 10700220.
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    377. Elevated endogenous cannabinoids in schizophrenia. Neuroreport. 1999 Jun 03; 10(8):1665-9. Leweke FM, Giuffrida A, Wurster U, Emrich HM, Piomelli D. PMID: 10501554.
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    378. Structural determinants for recognition and translocation by the anandamide transporter. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5802-7. Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ, Makriyannis A. PMID: 10318965; PMCID: PMC21941.
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    380. Anandamide transport inhibition by the vanilloid agonist olvanil. Eur J Pharmacol. 1999 Jan 01; 364(1):75-8. Beltramo M, Piomelli D. PMID: 9920187.
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    384. Inhibition of intestinal motility by anandamide, an endogenous cannabinoid. Eur J Pharmacol. 1997 Dec 11; 340(2-3):R7-8. Calignano A, La Rana G, Makriyannis A, Lin SY, Beltramo M, Piomelli D. PMID: 9537804.
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    387. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997 Aug 21; 388(6644):773-8. Stella N, Schweitzer P, Piomelli D. PMID: 9285589.
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    388. Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes. J Neurosci. 1997 May 01; 17(9):2939-46. Stella N, Estellés A, Siciliano J, Tencé M, Desagher S, Piomelli D, Glowinski J, Prémont J. PMID: 9096130; PMCID: PMC6573655.
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    396. Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. J Neurochem. 1996 Jan; 66(1):147-52. Lammers CH, Schweitzer P, Facchinetti P, Arrang JM, Madamba SG, Siggins GR, Piomelli D. PMID: 8522947.
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    405. Barium evokes glutamate release from rat brain synaptosomes by membrane depolarization: involvement of K+, Na+, and Ca2+ channels. J Neurochem. 1993 Oct; 61(4):1220-30. Sihra TS, Piomelli D, Nichols RA. PMID: 7690845.
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    406. Arachidonic acid in cell signaling. Curr Opin Cell Biol. 1993 Apr; 5(2):274-80. Piomelli D. PMID: 7685181.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    407. Dopamine D2 receptor signaling via the arachidonic acid cascade: modulation by cAMP-dependent protein kinase A and prostaglandin E2. J Lipid Mediat. 1993 Mar-Apr; 6(1-3):433-43. Piomelli D, Di Marzo V. PMID: 8395253.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    408. Participation of prostaglandin E2 in dopamine D2 receptor-dependent potentiation of arachidonic acid release. J Neurochem. 1992 Jul; 59(1):379-82. Di Marzo V, Piomelli D. PMID: 1351931.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    409. Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2649-53. Traiffort E, Ruat M, Arrang JM, Leurs R, Piomelli D, Schwartz JC. PMID: 1313563; PMCID: PMC48719.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    410. Molecular biology and pharmacology of histamine receptor subtypes. Clin Neuropharmacol. 1992; 15 Suppl 1 Pt A:149A-150A. Ruat M, Traiffort E, Leurs R, Arrang JM, Kouyoumdjian G, Tardivel-Lacombe J, Piomelli D, Diaz G, Schwartz JC. PMID: 1498787.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    411. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature. 1991 Sep 12; 353(6340):164-7. Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC. PMID: 1909771.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    412. Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6770-4. Piomelli D, Greengard P. PMID: 1650481; PMCID: PMC52170.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    413. Metabolism of arachidonic acid in nervous system of marine mollusk Aplysia californica. Am J Physiol. 1991 May; 260(5 Pt 2):R844-8. Piomelli D. PMID: 1903603.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    414. A phospholipase A2-stimulating protein regulated by protein kinase C in Aplysia neurons. Brain Res Mol Brain Res. 1991 Mar; 9(4):347-51. Calignano A, Piomelli D, Sacktor TC, Schwartz JH. PMID: 1645437.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    415. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling. Trends Pharmacol Sci. 1990 Sep; 11(9):367-73. Piomelli D, Greengard P. PMID: 2122564.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    416. Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8550-4. Piomelli D, Wang JK, Sihra TS, Nairn AC, Czernik AJ, Greengard P. PMID: 2554319; PMCID: PMC298320.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    417. Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-icosatrienoic acid in Aplysia: a possible second messenger in neurons. Proc Natl Acad Sci U S A. 1989 Mar; 86(5):1721-5. Piomelli D, Shapiro E, Zipkin R, Schwartz JH, Feinmark SJ. PMID: 2493649; PMCID: PMC286773.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    418. 12-keto-eicosatetraenoic acid. A biologically active eicosanoid in the nervous system of Aplysia. Ann N Y Acad Sci. 1989; 559:208-18. Piomelli D, Feinmark SJ, Shapiro E, Schwartz JH. PMID: 2774398.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    419. Biologically active metabolites of the 12-lipoxygenase pathway are formed by Aplysia nervous tissue. Ann N Y Acad Sci. 1989; 559:121-30. Feinmark SJ, Piomelli D, Shapiro E, Schwartz JH. PMID: 2505651.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    420. Formation and biological activity of 12-ketoeicosatetraenoic acid in the nervous system of Aplysia. J Biol Chem. 1988 Nov 15; 263(32):16591-6. Piomelli D, Feinmark SJ, Shapiro E, Schwartz JH. PMID: 3182804.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    421. The role of arachidonic acid metabolites in signal transduction in an identified neural network mediating presynaptic inhibition in Aplysia. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:425-33. Shapiro E, Piomelli D, Feinmark S, Vogel S, Chin G, Schwartz JH. PMID: 3151176.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    422. Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation. J Neurosci. 1987 Nov; 7(11):3675-86. Piomelli D, Shapiro E, Feinmark SJ, Schwartz JH. PMID: 3119791; PMCID: PMC6569051.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    423. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature. 1987 Jul 2-8; 328(6125):38-43. Piomelli D, Volterra A, Dale N, Siegelbaum SA, Kandel ER, Schwartz JH, Belardetti F. PMID: 2439918.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    424. Leukotriene biosynthesis by canine and human coronary arteries. J Pharmacol Exp Ther. 1987 Jun; 241(3):763-70. Piomelli D, Feinmark SJ, Cannon PJ. PMID: 3598901.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    425. Antagonistic actions of prostaglandins E2 and F2 alpha on the isolated lungs of the frog, Rana esculenta L. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987; 87(1):21-2. Piomelli D, Pinto A, Sannino C, Tota B. PMID: 2885133.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    426. Leukotrienes in teleost fish gills. Naturwissenschaften. 1985 May; 72(5):276-7. Piomelli D. PMID: 18443728.
      View in: PubMed   Mentions: 1     Fields:    
    427. The cyclo-oxygenase pathway in the avascular heart of the frog, Rana esculenta L. Gen Pharmacol. 1984; 15(4):309-13. Ghiara P, Parente L, Piomelli D. PMID: 6436138.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    428. Vasoconstrictory effects of adrenalin on the perfused head of the eel (Anguilla anguilla L.). Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983; 76(1):209-13. Pinto A, Piomelli D. PMID: 6139251.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    429. Different distribution of serotonin in an elasmobranch (Scyliorhinus stellaris) and in a teleost (Conger conger) fish. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983; 74(1):139-42. Piomelli D, Tota B. PMID: 6132758.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
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