Robert Spitale

Title(s)Professor, Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-7655, 1972
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    Assessing cell specific proteomes in the presence and absence of C5a complement signaling in Alzheimer?s disease models
    NIH/NIA R21AG068573Aug 1, 2020 - Apr 30, 2022
    Role: Principal Investigator
    A novel platform for the investigation of human microglia
    NIH/NIDA RF1DA048813Aug 15, 2019 - Aug 14, 2022
    Role: Co-Principal Investigator
    Uncovering the context-dependent complexity of neural RNA modifications
    NIH/NIMH R21MH116415Mar 1, 2018 - Feb 29, 2020
    Role: Co-Principal Investigator
    Determining the factors that control dose-dependent splicing regulation by a master regulator
    NIH/NIGMS R01GM121862Aug 4, 2017 - Apr 30, 2021
    Role: Co-Principal Investigator
    Multicellular simultaneous chemotranscriptomic profiling of nascent transcription during learning
    NIH/NIMH R21MH113062Aug 2, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Epitranscriptomic mechanisms of fear-related learning and memory
    NIH/NIMH R01MH109588Apr 15, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Cracking the RNA Localization Code
    NIH/NIGMS DP2GM119164Sep 30, 2015 - May 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Chemical Approaches to Analyzing RNA Structure Transcriptome-Wide. Chembiochem. 2020 Jul 31. England W, Garfio C, Spitale R. PMID: 32737940.
      View in: PubMed   Mentions:    Fields:    
    2. Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing. Nucleic Acids Res. 2020 Jun 19; 48(11):6294-6309. Saha K, England W, Fernandez MM, Biswas T, Spitale RC, Ghosh G. PMID: 32402057.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Assaying RNA solvent accessibility in living cells with LASER. Methods Enzymol. 2020; 641:401-411. Feng C, Spitale RC. PMID: 32713532.
      View in: PubMed   Mentions:    Fields:    
    4. Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. Oncogenesis. 2020 Feb 18; 9(2):25. Zocchi L, Mehta A, Wu SC, Wu J, Gu Y, Wang J, Suh S, Spitale RC, Benavente CA. PMID: 32071286.
      View in: PubMed   Mentions:
    5. An optimized chemical-genetic method for cell-specific metabolic labeling of RNA. Nat Methods. 2020 03; 17(3):311-318. Nainar S, Cuthbert BJ, Lim NM, England WE, Ke K, Sophal K, Quechol R, Mobley DL, Goulding CW, Spitale RC. PMID: 32015544.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents. Org Lett. 2019 10 04; 21(19):7948-7951. Li Y, Göhl M, Ke K, Vanderwal CD, Spitale RC. PMID: 31516001.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. Functional Conservation of LncRNA JPX Despite Sequence and Structural Divergence. J Mol Biol. 2020 01 17; 432(2):283-300. Karner H, Webb CH, Carmona S, Liu Y, Lin B, Erhard M, Chan D, Baldi P, Spitale RC, Sun S. PMID: 31518612.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. Neuron. 2019 09 25; 103(6):1016-1033.e10. Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. PMID: 31375314.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. Expanding the Scope of RNA Metabolic Labeling with Vinyl Nucleosides and Inverse Electron-Demand Diels-Alder Chemistry. ACS Chem Biol. 2019 08 16; 14(8):1698-1707. Kubota M, Nainar S, Parker SM, England W, Furche F, Spitale RC. PMID: 31310712.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nat Neurosci. 2019 04; 22(4):534-544. Li X, Zhao Q, Wei W, Lin Q, Magnan C, Emami MR, Wearick-Silva LE, Viola TW, Marshall PR, Yin J, Madugalle SU, Wang Z, Nainar S, Vågbø CB, Leighton LJ, Zajaczkowski EL, Ke K, Grassi-Oliveira R, Bjørås M, Baldi PF, Spitale RC, Bredy TW. PMID: 30778148.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Assaying RNA structure with LASER-Seq. Nucleic Acids Res. 2019 01 10; 47(1):43-55. Zinshteyn B, Chan D, England W, Feng C, Green R, Spitale RC. PMID: 30476193.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    12. Biochemical Methods To Image and Analyze RNA Localization: From One to Many. Biochemistry. 2019 02 05; 58(5):379-386. Li Y, Ke K, Spitale RC. PMID: 30444114.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Protected pyrimidine nucleosides for cell-specific metabolic labeling of RNA. Tetrahedron Lett. 2018 Oct 31; 59(44):3912-3915. Beasley S, Nguyen K, Fazio M, Spitale RC. PMID: 31031425.
      View in: PubMed   Mentions:    Fields:    
    14. Bioorthogonal Metabolic Labeling of Nascent RNA in Neurons Improves the Sensitivity of Transcriptome-Wide Profiling. ACS Chem Neurosci. 2018 07 18; 9(7):1858-1865. Zajaczkowski EL, Zhao QY, Zhang ZH, Li X, Wei W, Marshall PR, Leighton LJ, Nainar S, Feng C, Spitale RC, Bredy TW. PMID: 29874042.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Spatially Restricting Bioorthogonal Nucleoside Biosynthesis Enables Selective Metabolic Labeling of the Mitochondrial Transcriptome. ACS Chem Biol. 2018 06 15; 13(6):1474-1479. Nguyen K, Aggarwal MB, Feng C, Balderrama G, Fazio M, Mortazavi A, Spitale RC. PMID: 29756767.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. Improved Analysis of RNA Localization by Spatially Restricted Oxidation of RNA-Protein Complexes. Biochemistry. 2018 03 13; 57(10):1577-1581. Li Y, Aggarwal MB, Ke K, Nguyen K, Spitale RC. PMID: 29474061.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. Light-activated chemical probing of nucleobase solvent accessibility inside cells. Nat Chem Biol. 2018 02 14; 14(3):325. Feng C, Chan D, Joseph J, Muuronen M, Coldren WH, Dai N, Corrêa IR, Furche F, Hadad CM, Spitale RC. PMID: 29443971.
      View in: PubMed   Mentions: 1     Fields:    
    18. Facile synthesis and evaluation of a dual-functioning furoyl probe for in-cell SHAPE. Bioorg Med Chem Lett. 2018 02 15; 28(4):601-605. Chan D, Beasley S, Zhen Y, Spitale RC. PMID: 29398542.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    19. Light-activated chemical probing of nucleobase solvent accessibility inside cells. Nat Chem Biol. 2018 03; 14(3):276-283. Feng C, Chan D, Joseph J, Muuronen M, Coldren WH, Dai N, Corrêa IR, Furche F, Hadad CM, Spitale RC. PMID: 29334380.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Defining Functional Structured RNA inside Living Cells. Biochemistry. 2017 11 07; 56(44):5847-5848. Chan D, Spitale RC. PMID: 29064690.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    21. Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics. Genes Brain Behav. 2018 03; 17(3):e12426. Leighton LJ, Ke K, Zajaczkowski EL, Edmunds J, Spitale RC, Bredy TW. PMID: 28926184.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation. ACS Chem Biol. 2017 11 17; 12(11):2709-2714. Li Y, Aggarwal MB, Nguyen K, Ke K, Spitale RC. PMID: 28952711.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Initial in vitro functional characterization of serum exosomal microRNAs from patients with metastatic basal cell carcinoma. Br J Dermatol. 2017 11; 177(5):e187-e190. Chang J, Tran DC, Zhu GA, Li R, Whitson R, Kim YH, Gupta A, Afshari A, Antes T, Spitale RC, Chang ALS. PMID: 28369780.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. EC-tagging allows cell type-specific RNA analysis. Nucleic Acids Res. 2017 Sep 06; 45(15):e138. Hida N, Aboukilila MY, Burow DA, Paul R, Greenberg MM, Fazio M, Beasley S, Spitale RC, Cleary MD. PMID: 28641402.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Multiplex Aptamer Discovery through Apta-Seq and Its Application to ATP Aptamers Derived from Human-Genomic SELEX. ACS Chem Biol. 2017 08 18; 12(8):2149-2156. Abdelsayed MM, Ho BT, Vu MMK, Polanco J, Spitale RC, Lupták A. PMID: 28661647.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. MotifMap-RNA: a genome-wide map of RBP binding sites. Bioinformatics. 2017 Jul 01; 33(13):2029-2031. Liu Y, Sun S, Bredy T, Wood M, Spitale RC, Baldi P. PMID: 28334276.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Photo-controlled cell-specific metabolic labeling of RNA. Org Biomol Chem. 2017 Jun 21; 15(24):5117-5120. Feng C, Li Y, Spitale RC. PMID: 28569333.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. Temporal Labeling of Nascent RNA Using Photoclick Chemistry in Live Cells. J Am Chem Soc. 2017 06 21; 139(24):8090-8093. Nainar S, Kubota M, McNitt C, Tran C, Popik VV, Spitale RC. PMID: 28562039.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Comparative Analysis Reveals Furoyl in Vivo Selective Hydroxyl Acylation Analyzed by Primer Extension Reagents Form Stable Ribosyl Ester Adducts. Biochemistry. 2017 Apr 04; 56(13):1811-1814. Chan D, Feng C, Zhen Y, Flynn RA, Spitale RC. PMID: 28319368.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Measuring RNA structure transcriptome-wide with icSHAPE. Methods. 2017 05 01; 120:85-90. Chan D, Feng C, Spitale RC. PMID: 28336307.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    31. Cell-Selective Bioorthogonal Metabolic Labeling of RNA. J Am Chem Soc. 2017 02 15; 139(6):2148-2151. Nguyen K, Fazio M, Kubota M, Nainar S, Feng C, Li X, Atwood SX, Bredy TW, Spitale RC. PMID: 28139910.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Assaying RNA Structure Inside Living Cells with SHAPE. Methods Mol Biol. 2017; 1648:247-256. Feng C, Chan D, Spitale RC. PMID: 28766302.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    33. Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLoS One. 2016; 11(11):e0165913. Xu J, Spitale RC, Guan L, Flynn RA, Torre EA, Li R, Raber I, Qu K, Kern D, Knaggs HE, Chang HY, Chang AL. PMID: 27829007.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    34. Metabolic Incorporation of Azide Functionality into Cellular RNA. Chembiochem. 2016 Nov 17; 17(22):2149-2152. Nainar S, Beasley S, Fazio M, Kubota M, Dai N, Corrêa IR, Spitale RC. PMID: 27595557.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    35. Evolving insights into RNA modifications and their functional diversity in the brain. Nat Neurosci. 2016 09 27; 19(10):1292-8. Nainar S, Marshall PR, Tyler CR, Spitale RC, Bredy TW. PMID: 27669990.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    36. Chemical Tools for Dissecting the Role of lncRNAs in Epigenetic Regulation. ACS Chem Biol. 2016 08 19; 11(8):2091-100. Nainar S, Feng C, Spitale RC. PMID: 27267401.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    37. Defining the identity of mouse embryonic dermal fibroblasts. Genesis. 2016 08; 54(8):415-30. Budnick I, Hamburg-Shields E, Chen D, Torre E, Jarrell A, Akhtar-Zaidi B, Cordovan O, Spitale RC, Scacheri P, Atit RP. PMID: 27265328.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human ß Cell Function. Cell Metab. 2016 05 10; 23(5):909-20. Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. PMID: 27133132.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    39. Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE. Nat Protoc. 2016 Feb; 11(2):273-90. Flynn RA, Zhang QC, Spitale RC, Lee B, Mumbach MR, Chang HY. PMID: 26766114.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    40. The CDKN2A/p16(INK) (4a) 5'UTR sequence and translational regulation: impact of novel variants predisposing to melanoma. Pigment Cell Melanoma Res. 2016 Mar; 29(2):210-21. Andreotti V, Bisio A, Bressac-de Paillerets B, Harland M, Cabaret O, Newton-Bishop J, Pastorino L, Bruno W, Bertorelli R, De Sanctis V, Provenzani A, Menin C, Fronza G, Queirolo P, Spitale RC, Bianchi-Scarrà G, Inga A, Ghiorzo P. PMID: 26581427.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    41. The 5'-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding. Oncotarget. 2015 Nov 24; 6(37):39980-94. Bisio A, Latorre E, Andreotti V, Bressac-de Paillerets B, Harland M, Scarra GB, Ghiorzo P, Spitale RC, Provenzani A, Inga A. PMID: 26498684.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    42. Progress and challenges for chemical probing of RNA structure inside living cells. Nat Chem Biol. 2015 Dec; 11(12):933-41. Kubota M, Tran C, Spitale RC. PMID: 26575240.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    43. The emerging functions of regulatory RNA species in skin biology. Exp Dermatol. 2015 Nov; 24(11):827-8. Beasley SM, Plikus MV, Spitale RC, Pedersen IM. PMID: 26309056.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    44. Erratum: Structural imprints in vivo decode RNA regulatory mechanisms. Nature. 2015 Nov 12; 527(7577):264. Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung JW, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, Chang HY. PMID: 26416736.
      View in: PubMed   Mentions: 2     Fields:    
    45. RNA structure: merging chemistry and genomics for a holistic perspective. Bioessays. 2015 Oct; 37(10):1129-38. Kubota M, Chan D, Spitale RC. PMID: 26288173.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    46. Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):E3485-94. Liberman JA, Suddala KC, Aytenfisu A, Chan D, Belashov IA, Salim M, Mathews DH, Spitale RC, Walter NG, Wedekind JE. PMID: 26106162.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    47. Structural imprints in vivo decode RNA regulatory mechanisms. Nature. 2015 Mar 26; 519(7544):486-90. Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung JW, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, Chang HY. PMID: 25799993.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    48. Assessment of the genetic basis of rosacea by genome-wide association study. J Invest Dermatol. 2015 Jun; 135(6):1548-1555. Chang ALS, Raber I, Xu J, Li R, Spitale R, Chen J, Kiefer AK, Tian C, Eriksson NK, Hinds DA, Tung JY. PMID: 25695682.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    49. Technologies to probe functions and mechanisms of long noncoding RNAs. Nat Struct Mol Biol. 2015 Jan; 22(1):29-35. Chu C, Spitale RC, Chang HY. PMID: 25565030.
      View in: PubMed   Mentions: 36     Fields:    
    50. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature. 2015 Feb 12; 518(7538):249-53. Calo E, Flynn RA, Martin L, Spitale RC, Chang HY, Wysocka J. PMID: 25470060.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    51. Dissecting noncoding and pathogen RNA-protein interactomes. RNA. 2015 Jan; 21(1):135-43. Flynn RA, Martin L, Spitale RC, Do BT, Sagan SM, Zarnegar B, Qu K, Khavari PA, Quake SR, Sarnow P, Chang HY. PMID: 25411354.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    52. RNA structural analysis by evolving SHAPE chemistry. Wiley Interdiscip Rev RNA. 2014 Nov-Dec; 5(6):867-81. Spitale RC, Flynn RA, Torre EA, Kool ET, Chang HY. PMID: 25132067.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    53. Molecular targets of aspirin and cancer prevention. Br J Cancer. 2014 Jul 08; 111(1):61-7. Alfonso L, Ai G, Spitale RC, Bhat GJ. PMID: 24874482.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    54. Landscape and variation of RNA secondary structure across the human transcriptome. Nature. 2014 Jan 30; 505(7485):706-9. Wan Y, Qu K, Zhang QC, Flynn RA, Manor O, Ouyang Z, Zhang J, Spitale RC, Snyder MP, Segal E, Chang HY. PMID: 24476892.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    55. Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila. Mol Cell. 2013 Jul 25; 51(2):156-73. Ilik IA, Quinn JJ, Georgiev P, Tavares-Cadete F, Maticzka D, Toscano S, Wan Y, Spitale RC, Luscombe N, Backofen R, Chang HY, Akhtar A. PMID: 23870142.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    56. Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature. 2013 Jan 10; 493(7431):231-5. Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, Johnston D, Kim GE, Spitale RC, Flynn RA, Zheng GX, Aiyer S, Raj A, Rinn JL, Chang HY, Khavari PA. PMID: 23201690.
      View in: PubMed   Mentions: 283     Fields:    Translation:HumansCells
    57. RNA SHAPE analysis in living cells. Nat Chem Biol. 2013 Jan; 9(1):18-20. Spitale RC, Crisalli P, Flynn RA, Torre EA, Kool ET, Chang HY. PMID: 23178934.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    58. Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers. Genome Med. 2012 Feb 23; 4(2):14. Spitale RC, Cheng MY, Chun KA, Gorell ES, Munoz CA, Kern DG, Wood SM, Knaggs HE, Wulff J, Beebe KD, Chang AL. PMID: 22360970.
      View in: PubMed   Mentions: 4     Fields:    
    59. Understanding the transcriptome through RNA structure. Nat Rev Genet. 2011 Aug 18; 12(9):641-55. Wan Y, Kertesz M, Spitale RC, Segal E, Chang HY. PMID: 21850044.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    60. RNA templating the epigenome: long noncoding RNAs as molecular scaffolds. Epigenetics. 2011 May; 6(5):539-43. Spitale RC, Tsai MC, Chang HY. PMID: 21393997.
      View in: PubMed   Mentions: 62     Fields:    Translation:Cells
    61. Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res. 2011 Jan 01; 71(1):3-7. Tsai MC, Spitale RC, Chang HY. PMID: 21199792.
      View in: PubMed   Mentions: 249     Fields:    Translation:Humans
    62. Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation. J Am Chem Soc. 2009 Sep 16; 131(36):12908-9. Guo M, Spitale RC, Volpini R, Krucinska J, Cristalli G, Carey PR, Wedekind JE. PMID: 19702306.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    63. Single-atom imino substitutions at A9 and A10 reveal distinct effects on the fold and function of the hairpin ribozyme catalytic core. Biochemistry. 2009 Aug 25; 48(33):7777-9. Spitale RC, Volpini R, Mungillo MV, Krucinska J, Cristalli G, Wedekind JE. PMID: 19634899.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    64. Exploring ribozyme conformational changes with X-ray crystallography. Methods. 2009 Oct; 49(2):87-100. Spitale RC, Wedekind JE. PMID: 19559088.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    65. Identification of an imino group indispensable for cleavage by a small ribozyme. J Am Chem Soc. 2009 May 06; 131(17):6093-5. Spitale RC, Volpini R, Heller MG, Krucinska J, Cristalli G, Wedekind JE. PMID: 19354216.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    66. The structural basis for recognition of the PreQ0 metabolite by an unusually small riboswitch aptamer domain. J Biol Chem. 2009 Apr 24; 284(17):11012-6. Spitale RC, Torelli AT, Krucinska J, Bandarian V, Wedekind JE. PMID: 19261617.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    67. Shared traits on the reaction coordinates of ribonuclease and an RNA enzyme. Biochem Biophys Res Commun. 2008 Jun 20; 371(1):154-8. Torelli AT, Spitale RC, Krucinska J, Wedekind JE. PMID: 18423397.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    68. Efficient syntheses of 5'-deoxy-5'-fluoroguanosine and -inosine. J Org Chem. 2007 Oct 26; 72(22):8551-4. Spitale RC, Heller MG, Pelly AJ, Wedekind JE. PMID: 17902696.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    69. A posteriori design of crystal contacts to improve the X-ray diffraction properties of a small RNA enzyme. Acta Crystallogr D Biol Crystallogr. 2007 Jul; 63(Pt 7):812-25. MacElrevey C, Spitale RC, Krucinska J, Wedekind JE. PMID: 17582172.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    70. [Study of visual-perceptive ability in patients with parkinsonism]. Acta Neurol (Napoli). 1981 Feb; 3(1):197-203. Villardita C, Smirni P, Le Pira F, Spitale R, Zappala G. PMID: 7246292.
      View in: PubMed   Mentions:
    71. [Visual perceptive ability in Parkinson patients]. Acta Neurol Quad (Napoli). 1981; 42:197-203. Villardita C, Smirni P, Le Pira F, Spitale R, Zappala G. PMID: 7270050.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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