David Kevin Imagawa

Title(s)Clinical Professor, Surgery
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(714) 456-3884
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    1. Novel combination approaches to locoregional and systemic therapy in the management of primary and metastatic liver tumors. Clin Adv Hematol Oncol. 2023 Dec; 21(12):633-643. Dai M, Tiu BY, Chen M, Sing C, Sharma V, Hoyos JP, Scherr R, Lin WJ, Breuer JA, Dayyani F, Imagawa D, Abi-Jaoudeh N. PMID: 38039057.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Drug-Eluting Embolic Loaded with Tyrosine Kinase Inhibitor Targeted Therapies for Transarterial Chemoembolization in a VX2 Model. Cancers (Basel). 2023 Jun 18; 15(12). Abi-Jaoudeh N, Sadeghi B, Javan H, Na J, Beaton G, Tucci F, Ravula S, Imagawa DK. PMID: 37370846; PMCID: PMC10296897.
      View in: PubMed   Mentions:
    3. Targeting Hypoxia-Inducible Factor-1α for the Management of Hepatocellular Carcinoma. Cancers (Basel). 2023 May 12; 15(10). Huynh KN, Rao S, Roth B, Bryan T, Fernando DM, Dayyani F, Imagawa D, Abi-Jaoudeh N. PMID: 37345074; PMCID: PMC10216171.
      View in: PubMed   Mentions: 5  
    4. Delayed gastric emptying is associated with increased risk of mortality in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma. Updates Surg. 2023 Apr; 75(3):523-530. Dominguez OH, Grigorian A, Wolf RF, Imagawa DK, Nahmias JT, Jutric Z. PMID: 36309940; PMCID: PMC10042927.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Intra-Operative Abdominal Drain Placement for Gallbladder Cancer Surgery and Risk of Infectious Complications. Surg Infect (Larchmt). 2022 Feb; 23(1):22-28. Hasjim BJ, Grigorian A, Jutric Z, Wolf RF, Yamamoto M, Imagawa DK, Nahmias J. PMID: 34494909.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Phase I Trial on Arterial Embolization with Hypoxia Activated Tirapazamine for Unresectable Hepatocellular Carcinoma. J Hepatocell Carcinoma. 2021; 8:421-434. Abi-Jaoudeh N, Dayyani F, Chen PJ, Fernando D, Fidelman N, Javan H, Liang PC, Hwang JI, Imagawa DK. PMID: 34041204; PMCID: PMC8139681.
      View in: PubMed   Mentions: 10  Translation:CTClinical Trials
    7. Spontaneous choledochoduodenal fistula in a patient with a bile duct injury following laparoscopic cholecystectomy. J Surg Case Rep. 2019 May; 2019(5):rjz141. Gallagher SP, Imagawa DK. PMID: 31086653; PMCID: PMC6507672.
      View in: PubMed   Mentions: 2  
    8. Perioperative blood transfusion is associated with an increased risk for post-surgical infection following pancreaticoduodenectomy. HPB (Oxford). 2019 11; 21(11):1577-1584. Dosch AR, Grigorian A, Delaplain PT, Bartholomew TS, Won EJ, Gabriel V, Wolf RF, Jutric Z, Imagawa DK. PMID: 31040065.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    9. Bile Metabolism and Lithogenesis: An Update. Surg Clin North Am. 2019 Apr; 99(2):215-229. Dosch AR, Imagawa DK, Jutric Z. PMID: 30846031.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    10. Significance and Prevalence of Haziness Surrounding the Hepatic Artery and Celiac Axis on Computed Tomographic Imaging After Pancreaticoduodenectomy. J Comput Assist Tomogr. 2018 Jul/Aug; 42(4):637-641. Liu H, Imagawa D, Ward G, Dullet N, Lall C. PMID: 29489592.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Systematic review of islet cryopreservation. Islets. 2018 01 02; 10(1):40-49. Kojayan GG, Alexander M, Imagawa DK, Lakey JRT. PMID: 29315020; PMCID: PMC5800373.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    12. Development of Postoperative Diabetes Mellitus in Patients Undergoing Distal Pancreatectomy versus Whipple Procedure. Am Surg. 2017 Oct 01; 83(10):1050-1053. Nguyen A, Demirjian A, Yamamoto M, Hollenbach K, Imagawa DK. PMID: 29391093.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Efficacy of Negative Pressure Wound Treatment in Preventing Surgical Site Infections after Whipple Procedures. Am Surg. 2017 Oct 01; 83(10):1166-1169. Gupta R, Darby GC, Imagawa DK. PMID: 29391117.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    14. A case report on a rare anatomic variant of cystic duct insertion. J Surg Case Rep. 2017 Jul; 2017(7):rjx131. Yu JJ, Morell M, Lee JG, Imagawa DK. PMID: 28721192; PMCID: PMC5508545.
      View in: PubMed   Mentions:
    15. Management of an Accessory Bile Duct Leak Following Pancreaticoduodenectomy: A Novel Approach Utilizing a Percutaneous and Endoscopic Rendezvous. ACG Case Rep J. 2017; 4:e2. Rapp GA, Nelson KJ, Imagawa DK, Huang JY, Lee JG. PMID: 28138446; PMCID: PMC5244888.
      View in: PubMed   Mentions:
    16. Global Estimation of Surgical Procedures Needed for Forcibly Displaced Persons. World J Surg. 2016 Nov; 40(11):2628-2634. Zha Y, Stewart B, Lee E, Remick KN, Rothstein DH, Groen RS, Burnham G, Imagawa DK, Kushner AL. PMID: 27225996.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Total pancreatectomy and islet autotransplantation: A decade nationwide analysis. World J Transplant. 2016 Mar 24; 6(1):233-8. Fazlalizadeh R, Moghadamyeghaneh Z, Demirjian AN, Imagawa DK, Foster CE, Lakey JR, Stamos MJ, Ichii H. PMID: 27011922; PMCID: PMC4801800.
      View in: PubMed   Mentions: 7  
    18. Evolution in the Treatment of Delayed Postpancreatectomy Hemorrhage: Surgery to Interventional Radiology. Pancreas. 2015 Aug; 44(6):953-8. Khalsa BS, Imagawa DK, Chen JI, Dermirjian AN, Yim DB, Findeiss LK. PMID: 25906453.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    19. Perioperative goal-directed therapy and postoperative outcomes in patients undergoing high-risk abdominal surgery: a historical-prospective, comparative effectiveness study. Crit Care. 2015 Jun 19; 19:261. Cannesson M, Ramsingh D, Rinehart J, Demirjian A, Vu T, Vakharia S, Imagawa D, Yu Z, Greenfield S, Kain Z. PMID: 26088649; PMCID: PMC4512146.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    20. Closed-loop assisted versus manual goal-directed fluid therapy during high-risk abdominal surgery: a case-control study with propensity matching. Crit Care. 2015 Mar 19; 19:94. Rinehart J, Lilot M, Lee C, Joosten A, Huynh T, Canales C, Imagawa D, Demirjian A, Cannesson M. PMID: 25888403; PMCID: PMC4372998.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    21. Composite liver tumors: a radiologic-pathologic correlation. Clin Mol Hepatol. 2014 Dec; 20(4):406-10. Nayyar M, Imagawa DK, Tirkes T, Demirjian AN, Houshyar R, Sandrasegaran K, Nangia CS, Seery T, Bhargava P, Choi JI, Lall C. PMID: 25548749; PMCID: PMC4278074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Vascular reconstruction plays an important role in the treatment of pancreatic adenocarcinoma. J Vasc Surg. 2015 Feb; 61(2):475-80. Sgroi MD, Narayan RR, Lane JS, Demirjian A, Kabutey NK, Fujitani RM, Imagawa DK. PMID: 25441672.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    23. Magnetic resonance imaging following treatment of advanced hepatocellular carcinoma with sorafenib. Clin Mol Hepatol. 2014 Jun; 20(2):218-22. Choi JI, Imagawa DK, Bhosale P, Bhargava P, Tirkes T, Seery TE, Lall C. PMID: 25032190; PMCID: PMC4099339.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    24. Advances in managing hepatocellular carcinoma. Front Med. 2014 Jun; 8(2):175-89. Reataza M, Imagawa DK. PMID: 24810646.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Surgery for gallstone ileus: a nationwide comparison of trends and outcomes. Ann Surg. 2014 Feb; 259(2):329-35. Halabi WJ, Kang CY, Ketana N, Lafaro KJ, Nguyen VQ, Stamos MJ, Imagawa DK, Demirjian AN. PMID: 23295322.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    26. Massive congenital choledocal cyst. Liver Int. 2014 Jul; 34(6):e161. Tracy LE, Imagawa DK. PMID: 24330383.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Metastatic lesions to the liver. Int J Hepatol. 2013; 2013:104365. Ortiz J, Imagawa DK, Verzaro R, Serafini F, Kayler LK. PMID: 24349791; PMCID: PMC3855981.
      View in: PubMed   Mentions:
    28. Giant choledochal cyst mimicking massive gallbladder hydrops in an adult patient: multi detector computed tomography and magnetic resonance imaging findings correlated to gross and histopathological findings. J Clin Imaging Sci. 2013; 3:45. Choi JI, Lall C, Bhargava P, Imagawa DK. PMID: 24228213; PMCID: PMC3823391.
      View in: PubMed   Mentions: 2  
    29. Validation of revised American Joint Committee on Cancer staging for gallbladder cancer based on a single institution experience. Am Surg. 2013 Oct; 79(10):1045-9. Koh CY, Demirjian AN, Chen WP, McLaren CE, Imagawa DK. PMID: 24160796; PMCID: PMC4017658.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Gd-EOB-DTPA-Enhanced MRI for Detection of Liver Metastases from Colorectal Cancer: A Surgeon's Perspective! Int J Hepatol. 2013; 2013:572307. Lafaro KJ, Roumanis P, Demirjian AN, Lall C, Imagawa DK. PMID: 23653860; PMCID: PMC3638698.
      View in: PubMed   Mentions: 8  
    31. Limited utility of plain abdominal radiographs in evaluating intussusceptions secondary to long indwelling feeding tubes. J Clin Imaging Sci. 2013; 3:9. Yang A, Lall C, Bhargava P, Imagawa D. PMID: 23607078; PMCID: PMC3625884.
      View in: PubMed   Mentions:
    32. Pneumatosis in post-Whipple patients. Am Surg. 2012 Oct; 78(10):1105-8. Wikholm LI, Imagawa DK. PMID: 23025951.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Safety and efficacy of trans arterial chemoembolization with drug-eluting beads in hepatocellular cancer: a systematic review. Hepatogastroenterology. 2012 Jan-Feb; 59(113):255-60. Martin R, Geller D, Espat J, Kooby D, Sellars M, Goldstein R, Imagawa D, Scoggins C. PMID: 22251546.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    34. Endoscopic versus surgical treatment of downstream pancreatic duct stones in chronic pancreatitis. Am Surg. 2011 Nov; 77(11):1531-8. Hong J, Wang J, Keleman AM, Imagawa DK, Xu K, Wang W, Liu E, Niu W, Wang J, Sun Q, Wang J, Peng C, Zhao W, Niu J. PMID: 22196670.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Clinical presentation of hepatocellular carcinoma (HCC) in Asian-Americans versus non-Asian-Americans. J Immigr Minor Health. 2011 Oct; 13(5):842-8. Wong PY, Xia V, Imagawa DK, Hoefs J, Hu KQ. PMID: 20890660; PMCID: PMC3155747.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    36. Associated vascular injury in patients with bile duct injury during cholecystectomy. Am Surg. 2011 Oct; 77(10):1330-3. Keleman AM, Imagawa DK, Findeiss L, Hanna MH, Tan VH, Katz MH, Goodwin SC, Lane JS, Vajgrt D, Nguyen T, Smith CW. PMID: 22127081.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. Phase IIA trial testing erlotinib as an intervention against intraductal pancreatic mucinous neoplasms. Cancer Prev Res (Phila). 2011 Apr; 4(4):512-3. Lipkin S, Lee J, Imagawa D, Hewitt SM, Tucker C, Zell JA, Wong V, Garcia A, Gonzalez R, Della Zanna G, Richmond E, Rodriguez LM, Bigg M, Schnoll-Sussmans F, Meyskens F. PMID: 21464031; PMCID: PMC4492452.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    38. Adenosquamous versus adenocarcinoma of the pancreas: a population-based outcomes analysis. J Gastrointest Surg. 2011 Jan; 15(1):165-74. Katz MH, Taylor TH, Al-Refaie WB, Hanna MH, Imagawa DK, Anton-Culver H, Zell JA. PMID: 21082275; PMCID: PMC3023036.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansPHPublic Health
    39. Surgical management of recurrent ovarian cancer: the advantage of collaborative surgical management and a multidisciplinary approach. Gynecol Oncol. 2011 Jan; 120(1):29-32. Burton E, Chase D, Yamamoto M, de Guzman J, Imagawa D, Berman ML. PMID: 21055797.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    40. Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther. 2010 Jul; 9(7):2068-78. Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM, Katz MH. PMID: 20606044; PMCID: PMC4383085.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    41. The clinical presentation of chronic hepatitis B virus infection in Asian Americans: a single center retrospective study. J Clin Gastroenterol. 2010 May-Jun; 44(5):364-70. Mellen JS, Xia VW, Hashemzadeh M, Imagawa D, Jamal M, Hoefs J, Hu KQ. PMID: 19770675.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    42. Use of Seamguard to prevent pancreatic leak following distal pancreatectomy. Arch Surg. 2009 Oct; 144(10):894-9. Yamamoto M, Hayashi MS, Nguyen NT, Nguyen TD, McCloud S, Imagawa DK. PMID: 19841355.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    43. Hepatitis B immunoglobulin in preventing reinfection following liver transplantation. Expert Rev Anti Infect Ther. 2009 Apr; 7(3):321-8. Yamamoto M, Little G, Imagawa DK. PMID: 19344245.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Multidisciplinary management of resectable adenocarcinoma of the pancreatic head. Expert Rev Anticancer Ther. 2008 Oct; 8(10):1611-21. Yamamoto M, Imagawa DK, Katz MH. PMID: 18925853.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Use of Vascular Clamping in Hepatic Surgery: Lessons Learned From 1260 Liver Resections-Invited Critique. Arch Surg. 2008 Apr 01; 143(4):388. Imagawa DK. PMID: 28715573.
      View in: PubMed   Mentions:    Fields:    
    46. The influence of organ acceptance criteria on long-term graft survival: outcomes of a kidney transplant program. Am J Surg. 2008 Feb; 195(2):149-52. Foster CE, Weng RR, Smith CV, Imagawa DK. PMID: 18096123.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Cystic pancreatic neoplasm in pregnancy: a case report and review of the literature. Arch Surg. 2008 Jan; 143(1):84-6. Wiseman JE, Yamamoto M, Nguyen TD, Bonadio J, Imagawa DK. PMID: 18209157.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    48. Endoscopic ultrasound-guided fine-needle aspiration of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a report of 2 cases with literature review. Diagn Cytopathol. 2007 Sep; 35(9):601-6. Chopra S, Wu ML, Imagawa DK, Lee J, Gu M. PMID: 17703445.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    49. Argon beam coagulator for treatment of hepatic rupture with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. Obstet Gynecol. 2006 Feb; 107(2 Pt 2):525-6. Shrivastava VK, Imagawa D, Wing DA. PMID: 16449174.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    50. Laparoscopic distal pancreatic resection. Am Surg. 2005 Sep; 71(9):744-9. Root J, Nguyen N, Jones B, McCloud S, Lee J, Nguyen P, Chang K, Lin P, Imagawa D. PMID: 16468510.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    51. Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep; 24(9):1403-9. Si MS, Ji P, Lee M, Kwok J, Kusumoto J, Naasz E, Ng SC, Imagawa DK. PMID: 16143263.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    52. Hepatic artery pseudoaneurysm: a report of seven cases and a review of the literature. Surg Today. 2005; 35(7):543-7. Finley DS, Hinojosa MW, Paya M, Imagawa DK. PMID: 15976950.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    53. Fatal variceal rupture after sildenafil use: report of a case. Curr Surg. 2005 Jan-Feb; 62(1):55-6. Finley DS, Lugo B, Ridgway J, Teng W, Imagawa DK. PMID: 15708146.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    54. Use of Yttrium-90 TheraSphere for the treatment of unresectable hepatocellular carcinoma. Am Surg. 2004 Nov; 70(11):947-53. Liu MD, Uaje MB, Al-Ghazi MS, Fields D, Herman J, Kuo JV, Milne N, Nguyen TH, Ramsinghani NS, Tokita KM, Tsai FY, Vajgrt DJ, Imagawa DK. PMID: 15586503.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. Prevalence of metastases in hepatocellular carcinoma: risk factors and impact on survival. Am Surg. 2003 Oct; 69(10):879-85. Si MS, Amersi F, Golish SR, Ortiz JA, Zaky J, Finklestein D, Busuttil RW, Imagawa DK. PMID: 14570367.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    56. Expression of Kit and platelet-derived growth factor receptors alpha and beta in cholangiocarcinoma, and case report of therapy with imatinib mesylate (STI571). Anticancer Drugs. 2003 Sep; 14(8):651-7. Holcombe RF, Gu M, Imagawa D, Milovanovic T. PMID: 14501388.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    57. Immunomodulatory effects of docetaxel on human lymphocytes. Invest New Drugs. 2003 Aug; 21(3):281-90. Si MS, Imagawa DK, Ji P, Wei X, Holm B, Kwok J, Lee M, Reitz BA, Borie DC. PMID: 14578678.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    58. Farnesyltransferase inhibition: a novel method of immunomodulation. Int Immunopharmacol. 2003 Apr; 3(4):475-83. Si MS, Ji P, Tromberg BJ, Lee M, Kwok J, Ng SC, Imagawa DK. PMID: 12689653.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    59. Carcinoid tumors of the common bile duct: report of two cases. Surg Today. 2003; 33(7):553-5. Podnos YD, Jimenez JC, Zainabadi K, Ji P, Cooke J, Busuttil RW, Imagawa DK. PMID: 14507005.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
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