Loading...

Stephen Hanessian

Title(s)Professor, Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-5449
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Identification of the anti-neoplastic target of bioactive FTY720 analogs
    NIH/NCI R21CA178230Aug 1, 2013 - Jul 31, 2015
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Total Synthesis and Stereochemical Confirmation of (-)-Olivil, (+)-Cycloolivil, (-)-Alashinols F and G, (+)-Cephafortin A, and Their Congeners: Filling in Biosynthetic Gaps. Org Lett. 2020 May 01; 22(9):3345-3350. Reddy Vakiti J, Hanessian S. PMID: 32293189.
      View in: PubMed   Mentions:    Fields:    
    2. Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras. J Org Chem. 2020 Mar 20; 85(6):4237-4247. Hocine S, Berger G, Hanessian S. PMID: 32134267.
      View in: PubMed   Mentions:    Fields:    
    3. Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines. ACS Med Chem Lett. 2020 May 14; 11(5):686-690. Bachollet SPJT, Vece V, McCracken AN, Finicle BT, Selwan E, Ben Romdhane N, Dahal A, Ramirez C, Edinger AL, Hanessian S. PMID: 32435371.
      View in: PubMed   Mentions:
    4. Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs. Nucleosides Nucleotides Nucleic Acids. 2020; 39(1-3):384-406. Salinas JC, Seth PP, Hanessian S. PMID: 31380707.
      View in: PubMed   Mentions:    Fields:    
    5. Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A. Bioorg Med Chem Lett. 2019 09 15; 29(18):2681-2685. Garsi JB, Vece V, Sernissi L, Auger-Morin C, Hanessian S, McCracken AN, Selwan E, Ramirez C, Dahal A, Romdhane NB, Finicle BT, Edinger AL. PMID: 31383588.
      View in: PubMed   Mentions: 1     Fields:    
    6. Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines. Org Lett. 2019 09 06; 21(17):6593-6596. Duchamp E, Simard BD, Hanessian S. PMID: 31240939.
      View in: PubMed   Mentions:    Fields:    
    7. Synthesis of 1',2'-methano-2',3'-dideoxynucleosides as potential antivirals. Bioorg Med Chem Lett. 2019 02 15; 29(4):597-600. Rico L, Hanessian S. PMID: 30612845.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs. Mol Cell Proteomics. 2019 03; 18(3):408-422. Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault P. PMID: 30482847.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways. Eur J Med Chem. 2018 Nov 05; 159:217-242. Garsi JB, Sernissi L, Vece V, Hanessian S, McCracken AN, Simitian G, Edinger AL. PMID: 30292898.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs. Org Lett. 2018 09 07; 20(17):5296-5299. Salinas JC, Yu J, Østergaard M, Seth PP, Hanessian S. PMID: 30146887.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    11. Total Synthesis and Absolute Stereochemical Assignment of the Insecticidal Metabolites Yaequinolones J1 and J2. Org Lett. 2018 07 20; 20(14):4277-4280. Vece V, Jakkepally S, Hanessian S. PMID: 29975546.
      View in: PubMed   Mentions: 1     Fields:    
    12. Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. ChemMedChem. 2018 08 10; 13(15):1541-1548. Kanazawa H, Saavedra OM, Maianti JP, Young SA, Izquierdo L, Smith TK, Hanessian S, Kondo J. PMID: 29766661.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Design and synthesis of bridged piperidine and piperazine isosteres. Bioorg Med Chem Lett. 2018 08 15; 28(15):2627-2630. Maertens G, Saavedra OM, Vece V, Reyes MAV, Hocine S, Öney E, Goument B, Mirguet O, Le Tiran A, Gloanec P, Hanessian S. PMID: 29937060.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma. Bioorg Med Chem Lett. 2018 08 15; 28(15):2652-2654. Rico L, Østergaard ME, Bell M, Seth PP, Hanessian S. PMID: 30042045.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Recent Progress in the Chemistry of Daphniphyllum Alkaloids †. Chem Rev. 2017 Mar 08; 117(5):4104-4146. Chattopadhyay AK, Hanessian S. PMID: 28205435.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    16. Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors. Bioorg Med Chem. 2017 01 01; 25(1):38-52. Saavedra OM, Karila D, Brossard D, Rojas A, Dupuis D, Gohier A, Mannoury la Cour C, Millan MJ, Ortuno JC, Hanessian S. PMID: 28029458.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. 2016 11 01; 126(11):4088-4102. Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL. PMID: 27669461.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    18. Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia. 2017 03; 31(3):669-677. McCracken AN, McMonigle RJ, Tessier J, Fransson R, Perryman MS, Chen B, Keebaugh A, Selwan E, Barr SA, Kim SM, Roy SG, Liu G, Fallegger D, Sernissi L, Brandt C, Moitessier N, Snider AJ, Clare S, Müschen M, Huwiler A, Kleinman MT, Hanessian S, Edinger AL. PMID: 27573555.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death. Bioorg Med Chem. 2016 09 15; 24(18):4390-4397. Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S. PMID: 27475534.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Solution and Solid-Phase Stereocontrolled Synthesis of 1,2-cis-Glycopyranosides with Minimally Protected Glycopyranosyl Donors Catalyzed by BF3-N,N-Dimethylformamide Complex. Org Lett. 2016 07 01; 18(13):3106-9. St-Pierre G, Hanessian S. PMID: 27301355.
      View in: PubMed   Mentions: 1     Fields:    
    21. Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis. J Org Chem. 2016 06 17; 81(12):5074-86. Chattopadhyay AK, Berger G, Hanessian S. PMID: 27251014.
      View in: PubMed   Mentions: 1     Fields:    
    22. Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs. Bioorg Med Chem. 2016 06 01; 24(11):2397-409. St-Pierre G, Pal S, Østergaard ME, Zhou T, Yu J, Tanowitz M, Seth PP, Hanessian S. PMID: 27117693.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Synthesis of a Model Tetracyclic Core Structure of Calyciphylline B-Type Alkaloids. J Org Chem. 2016 Mar 04; 81(5):2182-8. Chattopadhyay AK, Menz H, Ly VL, Dorich S, Hanessian S. PMID: 26878089.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA. Org Biomol Chem. 2016 Feb 14; 14(6):2034-40. Giacometti RD, Salinas JC, Østergaard ME, Swayze EE, Seth PP, Hanessian S. PMID: 26765794.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms. Angew Chem Int Ed Engl. 2016 Mar 18; 55(13):4156-86. Büschleb M, Dorich S, Hanessian S, Tao D, Schenthal KB, Overman LE. PMID: 26836448.
      View in: PubMed   Mentions: 17     Fields:    
    26. Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum. Angew Chem Int Ed Engl. 2016 Feb 12; 55(7):2577-81. Chattopadhyay AK, Ly VL, Jakkepally S, Berger G, Hanessian S. PMID: 26765928.
      View in: PubMed   Mentions: 3     Fields:    
    27. Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes. ACS Med Chem Lett. 2016 Jan 14; 7(1):6-9. Hanessian S. PMID: 26819656.
      View in: PubMed   Mentions:
    28. Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo. ACS Chem Biol. 2016 Feb 19; 11(2):409-14. Chen B, Roy SG, McMonigle RJ, Keebaugh A, McCracken AN, Selwan E, Fransson R, Fallegger D, Huwiler A, Kleinman MT, Edinger AL, Hanessian S. PMID: 26653336.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    29. Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods. Chem Commun (Camb). 2015 Nov 28; 51(92):16437-49. Chattopadhyay AK, Hanessian S. PMID: 26490402.
      View in: PubMed   Mentions: 1     Fields:    
    30. Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis. Chem Commun (Camb). 2015 Nov 28; 51(92):16450-67. Chattopadhyay AK, Hanessian S. PMID: 26490499.
      View in: PubMed   Mentions: 1     Fields:    
    31. Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer. Angew Chem Int Ed Engl. 2015 Nov 02; 54(45):13268-72. Berger G, Vilchis-Reyes M, Hanessian S. PMID: 26346999.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    32. Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences. J Org Chem. 2014 Dec 05; 79(23):11651-60. Salinas JC, Migawa MT, Merner BL, Hanessian S. PMID: 25401196.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    33. Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren. J Org Chem. 2014 Oct 17; 79(20):9531-45. Hanessian S, Chénard E, Guesné S, Cusson JP. PMID: 25285791.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    34. Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules. Beilstein J Org Chem. 2014; 10:1848-77. Focken T, Hanessian S. PMID: 25246946.
      View in: PubMed   Mentions:
    35. Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs. ACS Chem Biol. 2014 Sep 19; 9(9):2067-73. Maianti JP, Kanazawa H, Dozzo P, Matias RD, Feeney LA, Armstrong ES, Hildebrandt DJ, Kane TR, Gliedt MJ, Goldblum AA, Linsell MS, Aggen JB, Kondo J, Hanessian S. PMID: 25019242.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes. Org Lett. 2014 May 16; 16(10):2668-71. Chénard E, Hanessian S. PMID: 24805004.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    37. Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists. ACS Med Chem Lett. 2014 May 08; 5(5):550-5. Hanessian S, Jennequin T, Boyer N, Babonneau V, Soma U, Mannoury la Cour C, Millan MJ, De Nanteuil G. PMID: 24900878.
      View in: PubMed   Mentions:
    38. Iminium ion-enamine cascade cyclizations: facile access to structurally diverse azacyclic compounds and natural products. Org Lett. 2014 Jan 03; 16(1):232-5. Hanessian S, Chattopadhyay AK. PMID: 24341416.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    39. Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists. Bioorg Med Chem Lett. 2014 Jan 15; 24(2):510-4. Hanessian S, Babonneau V, Boyer N, Mannoury la Cour C, Millan MJ, De Nanteuil G. PMID: 24374277.
      View in: PubMed   Mentions: 1     Fields:    
    40. Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). ACS Med Chem Lett. 2013 Oct 10; 4(10). Fransson R, McCracken AN, Chen B, McMonigle RJ, Edinger AL, Hanessian S. PMID: 24273632.
      View in: PubMed   Mentions:
    41. A constrained tricyclic nucleic acid analogue of a-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability. J Org Chem. 2013 Sep 20; 78(18):9064-75. Hanessian S, Wagger J, Merner BL, Giacometti RD, Ostergaard ME, Swayze EE, Seth PP. PMID: 23937256.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    42. Synthesis of cis- and trans-a-l-[4.3.0]bicyclo-DNA monomers for antisense technology: methods for the diastereoselective formation of bicyclic nucleosides. J Org Chem. 2013 Sep 20; 78(18):9051-63. Hanessian S, Schroeder BR, Merner BL, Chen B, Swayze EE, Seth PP. PMID: 23937280.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    43. Studies toward the generation of functionalized quaternary carbon centers relying on Wittig and Wittig-Still allylic ether anionic transpositions. J Org Chem. 2013 Sep 06; 78(17):8915-21. Hanessian S, Dorich S, Chattopadhyay AK, Büschleb M. PMID: 23915281.
      View in: PubMed   Mentions:    Fields:    
    44. Concise and stereocontrolled synthesis of the tetracyclic core of daphniglaucin C. Org Lett. 2013 Aug 16; 15(16):4134-7. Hanessian S, Dorich S, Menz H. PMID: 23889206.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    45. Crystal structure of a bioactive pactamycin analog bound to the 30S ribosomal subunit. J Mol Biol. 2013 Oct 23; 425(20):3907-10. Tourigny DS, Fernández IS, Kelley AC, Vakiti RR, Chattopadhyay AK, Dorich S, Hanessian S, Ramakrishnan V. PMID: 23702293.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    46. Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites. ChemMedChem. 2013 May; 8(5):733-9. Kondo J, Koganei M, Maianti JP, Ly VL, Hanessian S. PMID: 23436717.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    47. Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity. Bioorg Med Chem. 2013 Apr 01; 21(7):1775-86. Hanessian S, Vakiti RR, Chattopadhyay AK, Dorich S, Lavallée C. PMID: 23434136.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Total synthesis of pactamycin and pactamycate: a detailed account. J Org Chem. 2012 Nov 02; 77(21):9458-72. Hanessian S, Vakiti RR, Dorich S, Banerjee S, Deschênes-Simard B. PMID: 23083207.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    49. Structure-based design of a highly constrained nucleic acid analogue: improved duplex stabilization by restricting sugar pucker and torsion angle ?. Angew Chem Int Ed Engl. 2012 Nov 05; 51(45):11242-5. Hanessian S, Schroeder BR, Giacometti RD, Merner BL, Ostergaard M, Swayze EE, Seth PP. PMID: 22915274.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    50. The enterprise of synthesis: from concept to practice. J Org Chem. 2012 Aug 17; 77(16):6657-88. Hanessian S. PMID: 22784216.
      View in: PubMed   Mentions: 5     Fields:    
    51. A new approach to the synthesis of peptidomimetic renin inhibitors: palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones. Org Lett. 2012 Jun 15; 14(12):3222-5. Hanessian S, Chénard E. PMID: 22668074.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    52. Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation. Org Lett. 2011 Dec 16; 13(24):6476-9. Hanessian S, Maianti JP, Matias RD, Feeney LA, Armstrong ES. PMID: 22085292.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    53. Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue. ACS Med Chem Lett. 2011 Dec 08; 2(12):924-8. Hanessian S, Giguère A, Grzyb J, Maianti JP, Saavedra OM, Aggen JB, Linsell MS, Goldblum AA, Hildebrandt DJ, Kane TR, Dozzo P, Gliedt MJ, Matias RD, Feeney LA, Armstrong ES. PMID: 24900282.
      View in: PubMed   Mentions:
    54. Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues. ChemMedChem. 2011 Nov 04; 6(11):1961-6. Szychowski J, Kondo J, Zahr O, Auclair K, Westhof E, Hanessian S, Keillor JW. PMID: 21905229.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    55. Total synthesis of pactamycin. Angew Chem Int Ed Engl. 2011 Apr 04; 50(15):3497-500. Hanessian S, Vakiti RR, Dorich S, Banerjee S, Lecomte F, DelValle JR, Zhang J, Deschênes-Simard B. PMID: 21370372.
      View in: PubMed   Mentions: 13     Fields:    
    56. Total synthesis of (+)-ent-cyclizidine: absolute configurational confirmation of antibiotic M146791. Org Lett. 2011 Mar 04; 13(5):1048-51. Hanessian S, Soma U, Dorich S, Deschênes-Simard B. PMID: 21271743.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    57. Applications of organocatalytic asymmetric synthesis to drug prototypes--dual action and selective inhibitors of n-nitric oxide synthase with activity against the 5-HT1D/1B subreceptors. Org Lett. 2011 Mar 04; 13(5):840-3. Hanessian S, Stoffman E, Mi X, Renton P. PMID: 21271688.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    58. Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. J Med Chem. 2010 Dec 09; 53(23):8387-99. Auzzas L, Larsson A, Matera R, Baraldi A, Deschênes-Simard B, Giannini G, Cabri W, Battistuzzi G, Gallo G, Ciacci A, Vesci L, Pisano C, Hanessian S. PMID: 21073160.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    59. Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. Bioorg Med Chem Lett. 2010 Dec 01; 20(23):6925-8. Hanessian S, Larsson A, Fex T, Knecht W, Blomberg N. PMID: 21035339.
      View in: PubMed   Mentions: 7     Fields:    
    60. Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria. Bioorg Med Chem Lett. 2010 Dec 01; 20(23):7097-101. Hanessian S, Pachamuthu K, Szychowski J, Giguère A, Swayze EE, Migawa MT, François B, Kondo J, Westhof E. PMID: 20970332.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    61. Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit. J Org Chem. 2010 Aug 20; 75(16):5601-18. Hanessian S, Focken T, Mi X, Oza R, Chen B, Ritson D, Beaudegnies R. PMID: 20704433.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    62. Total synthesis of jerangolid A. Org Lett. 2010 Jul 16; 12(14):3172-5. Hanessian S, Focken T, Oza R. PMID: 20565089.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    63. Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics. J Org Chem. 2010 May 07; 75(9):2861-76. Hanessian S, Maji DK, Govindan S, Matera R, Tintelnot-Blomley M. PMID: 20392053.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    64. Total synthesis of "aliskiren": the first Renin inhibitor in clinical practice for hypertension. Org Lett. 2010 Apr 16; 12(8):1816-9. Hanessian S, Guesné S, Chénard E. PMID: 20235519.
      View in: PubMed   Mentions: 1     Fields:    
    65. Vorinostat-like molecules as structural, stereochemical, and pharmacological tools. ACS Med Chem Lett. 2010 May 13; 1(2):70-4. Hanessian S, Auzzas L, Larsson A, Zhang J, Giannini G, Gallo G, Ciacci A, Cabri W. PMID: 24900179.
      View in: PubMed   Mentions:
    66. Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin. Chem Commun (Camb). 2010 Mar 28; 46(12):2013-5. Hanessian S, Maianti JP. PMID: 20221476.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    67. Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):1924-7. Hanessian S, Shao Z, Betschart C, Rondeau JM, Neumann U, Tintelnot-Blomley M. PMID: 20172717.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    68. Total synthesis of oidiodendrolides and related norditerpene dilactones from a common precursor: metabolites CJ-14,445, LL-Z1271gamma, oidiolactones A, B, C, and D, and nagilactone F. Org Lett. 2009 Oct 15; 11(20):4640-3. Hanessian S, Boyer N, Reddy GJ, Deschênes-Simard B. PMID: 19778011.
      View in: PubMed   Mentions: 1     Fields:    
    69. Total synthesis and structural revision of the presumed aeruginosins 205A and B. Org Lett. 2009 Sep 17; 11(18):4232-5. Hanessian S, Wang X, Ersmark K, Del Valle JR, Klegraf E. PMID: 19691354.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    70. From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett. 2009 Sep 15; 19(18):5429-32. Hanessian S, Therrien E, Zhang J, Otterlo Wv, Xue Y, Gustafsson D, Nilsson I, Fjellström O. PMID: 19674897.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    71. Surface-functionalized ultrasmall superparamagnetic nanoparticles as magnetic delivery vectors for camptothecin. ChemMedChem. 2009 Jun; 4(6):988-97. Cengelli F, Grzyb JA, Montoro A, Hofmann H, Hanessian S, Juillerat-Jeanneret L. PMID: 19347834.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    72. Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans. Org Lett. 2009 Jan 15; 11(2):429-32. Hanessian S, Szychowski J, Maianti JP. PMID: 19072132.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    73. The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids. Acc Chem Res. 2008 Oct; 41(10):1241-51. Hanessian S, Auzzas L. PMID: 18646869.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    74. Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles. Org Lett. 2008 Apr 03; 10(7):1381-4. Hanessian S, Simard D, Deschênes-Simard B, Chenel C, Haak E. PMID: 18314995.
      View in: PubMed   Mentions: 1     Fields:    
    75. Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):1972-6. Hanessian S, Simard D, Bayrakdarian M, Therrien E, Nilsson I, Fjellström O. PMID: 18289852.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Chemistry and biology of the aeruginosin family of serine protease inhibitors. Angew Chem Int Ed Engl. 2008; 47(7):1202-23. Ersmark K, Del Valle JR, Hanessian S. PMID: 18076006.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    77. Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs. Bioorg Med Chem. 2008 Mar 15; 16(6):2921-31. Hanessian S, Grzyb JA, Cengelli F, Juillerat-Jeanneret L. PMID: 18226908.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    78. Alternative and expedient asymmetric syntheses of L-(+)-noviose. Org Lett. 2008 Jan 17; 10(2):261-4. Hanessian S, Auzzas L. PMID: 18081305.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    79. Targeting ACE and ECE with dual acting inhibitors. Bioorg Med Chem Lett. 2008 Feb 01; 18(3):1058-62. Hanessian S, Guesné S, Riber L, Marin J, Benoist A, Mennecier P, Rupin A, Verbeuren TJ, De Nanteuil G. PMID: 18160283.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    80. Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure. J Org Chem. 2008 Feb 15; 73(4):1181-91. Hanessian S, Vinci V, Fettis K, Maris T, Viet MT. PMID: 18062697.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    81. Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity. ChemMedChem. 2007 Nov; 2(11):1631-8. Kondo J, Pachamuthu K, François B, Szychowski J, Hanessian S, Westhof E. PMID: 17722211.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    82. Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15; 17(22):6261-5. Hanessian S, Auzzas L, Giannini G, Marzi M, Cabri W, Barbarino M, Vesci L, Pisano C. PMID: 17892933.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    83. Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants. J Org Chem. 2007 Aug 17; 72(17):6353-63. Loiseleur O, Ritson D, Nina M, Crowley P, Wagner T, Hanessian S. PMID: 17658846.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    84. Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin. J Med Chem. 2007 May 17; 50(10):2352-69. Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. PMID: 17458946.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    85. Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin. Bioorg Med Chem Lett. 2007 Jun 15; 17(12):3480-5. Hanessian S, Ersmark K, Wang X, Del Valle JR, Blomberg N, Xue Y, Fjellström O. PMID: 17428662.
      View in: PubMed   Mentions: 4     Fields:    
    86. 6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase. Bioorg Med Chem Lett. 2007 Jun 01; 17(11):3221-5. Hanessian S, Szychowski J, Campos-Reales Pineda NB, Furtos A, Keillor JW. PMID: 17400454.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    87. Structure-based organic synthesis of a tricyclic N-malayamycin analogue. J Org Chem. 2006 Dec 22; 71(26):9807-17. Hanessian S, Ritson DJ. PMID: 17168600.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    88. Structure-based organic synthesis of drug prototypes: a personal odyssey. ChemMedChem. 2006 Dec; 1(12):1301-30. Hanessian S. PMID: 17091524.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    89. Total synthesis and stereochemical confirmation of manassantin A, B, and B1. Org Lett. 2006 Nov 23; 8(24):5477-80. Hanessian S, Reddy GJ, Chahal N. PMID: 17107051.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    90. Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst. Org Lett. 2006 Nov 23; 8(24):5481-4. Hanessian S, Giroux S, Larsson A. PMID: 17107052.
      View in: PubMed   Mentions: 6     Fields:    
    91. Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline. Org Lett. 2006 Oct 12; 8(21):4787-90. Hanessian S, Shao Z, Warrier JS. PMID: 17020303.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    92. Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):491-4. Hanessian S, Charron G, Billich A, Guerini D. PMID: 17070046.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    93. A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors. J Med Chem. 2006 Oct 05; 49(20):5885-94. Moitessier N, Therrien E, Hanessian S. PMID: 17004704.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    94. Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design. J Org Chem. 2006 Sep 15; 71(19):7403-11. Hanessian S, Chahal N, Giroux S. PMID: 16958535.
      View in: PubMed   Mentions: 2     Fields:    
    95. Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia. 2006 Sep; 54(4):272-84. Ogier C, Bernard A, Chollet AM, LE Diguardher T, Hanessian S, Charton G, Khrestchatisky M, Rivera S. PMID: 16845676.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    96. Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A. Org Lett. 2006 Aug 31; 8(18):4047-9. Hanessian S, Mainetti E, Lecomte F. PMID: 16928070.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    97. Total synthesis and structural confirmation of chlorodysinosin A. J Am Chem Soc. 2006 Aug 16; 128(32):10491-5. Hanessian S, Del Valle JR, Xue Y, Blomberg N. PMID: 16895415.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    98. Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). J Med Chem. 2006 Jul 27; 49(15):4544-67. Hanessian S, Yang G, Rondeau JM, Neumann U, Betschart C, Tintelnot-Blomley M. PMID: 16854060.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    99. Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA. Bioorg Med Chem Lett. 2006 Sep 15; 16(18):4784-7. Hanessian S, Vinci V, Auzzas L, Marzi M, Giannini G. PMID: 16870438.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    100. Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme. J Org Chem. 2006 Mar 31; 71(7):2760-78. Hanessian S, Gauchet C, Charron G, Marin J, Nakache P. PMID: 16555831.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    101. Docking of aminoglycosides to hydrated and flexible RNA. J Med Chem. 2006 Feb 09; 49(3):1023-33. Moitessier N, Westhof E, Hanessian S. PMID: 16451068.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    102. Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):1032-6. Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellström O, Xue Y. PMID: 16290930.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    103. Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues. J Comb Chem. 2005 Nov-Dec; 7(6):837-42. Hanessian S, Kothakonda KK. PMID: 16283793.
      View in: PubMed   Mentions: 2     Fields:    
    104. Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones. Chirality. 2005 Nov; 17(9):540-3. Hanessian S, Govindan S, Warrier JS. PMID: 16189834.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    105. Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates. Curr Opin Drug Discov Devel. 2005 Nov; 8(6):798-819. Hanessian S. PMID: 16312154.
      View in: PubMed   Mentions: 2     Fields:    
    106. 3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin. Bioorg Med Chem. 2005 Sep 01; 13(17):5283-8. Hanessian S, Kothakonda KK. PMID: 15994084.
      View in: PubMed   Mentions: 1     Fields:    
    107. Total synthesis and structural confirmation of (+)-longicin. Org Lett. 2005 Sep 01; 7(18):3989-92. Hanessian S, Giroux S, Buffat M. PMID: 16119949.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    108. Total synthesis of N-malayamycin A and related bicyclic purine and pyrimidine nucleosides. J Org Chem. 2005 Aug 19; 70(17):6721-34. Hanessian S, Huang G, Chenel C, Machaalani R, Loiseleur O. PMID: 16095292.
      View in: PubMed   Mentions: 1     Fields:    
    109. Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids. J Org Chem. 2005 Aug 19; 70(17):6735-45. Hanessian S, Hou Y, Bayrakdarian M, Tintelnot-Blomley M. PMID: 16095293.
      View in: PubMed   Mentions:    Fields:    
    110. Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids. J Org Chem. 2005 Aug 19; 70(17):6746-56. Hanessian S, Yun H, Hou Y, Tintelnot-Blomley M. PMID: 16095294.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    111. Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem. 2005 Aug 11; 48(16):5175-90. Hanessian S, Yun H, Hou Y, Yang G, Bayrakdarian M, Therrien E, Moitessier N, Roggo S, Veenstra S, Tintelnot-Blomley M, Rondeau JM, Ostermeier C, Strauss A, Ramage P, Paganetti P, Neumann U, Betschart C. PMID: 16078837.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    112. Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric implications of nucleophilic alkene, alkyne, and allene tethers. J Org Chem. 2005 Jun 24; 70(13):5070-85. Hanessian S, Tremblay M, Marzi M, Del Valle JR. PMID: 15960507.
      View in: PubMed   Mentions: 5     Fields:    
    113. Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site. Angew Chem Int Ed Engl. 2004 Dec 10; 43(48):6735-8. François B, Szychowski J, Adhikari SS, Pachamuthu K, Swayze EE, Griffey RH, Migawa MT, Westhof E, Hanessian S. PMID: 15593140.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    114. Tandem functionalization of nonactivated alkenes and alkynes in intramolecular N-acyloxyiminium ion carbocyclization. Synthesis of 6-substituted hydroindole 2-carboxylic acids. Org Lett. 2004 Dec 09; 6(25):4683-6. Hanessian S, Tremblay M. PMID: 15575660.
      View in: PubMed   Mentions: 2     Fields:    
    115. Synthesis of 3 10-helix-inducing constrained analogues of L-proline. J Org Chem. 2004 Jul 23; 69(15):4891-9. Hanessian S, Papeo G, Fettis K, Therrien E, Viet MT. PMID: 15255713.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    116. Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):11996-2001. Hanessian S, Mascitti V, Giroux S. PMID: 15210988.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    117. The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin. J Am Chem Soc. 2004 May 19; 126(19):6064-71. Hanessian S, Tremblay M, Petersen JF. PMID: 15137772.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    118. Sulfonamide-based acyclic and conformationally constrained MMP inhibitors: from computer-assisted design to nanomolar compounds. Curr Top Med Chem. 2004; 4(12):1269-87. Hanessian S, Moitessier N. PMID: 15320726.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    119. Total synthesis and structural confirmation of malayamycin A: a novel bicyclic C-nucleoside from Streptomyces malaysiensis. Org Lett. 2003 Nov 13; 5(23):4277-80. Hanessian S, Marcotte S, Machaalani R, Huang G. PMID: 14601979.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    120. Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate. J Am Chem Soc. 2003 Nov 12; 125(45):13784-92. Hanessian S, Yang Y, Giroux S, Mascitti V, Ma J, Raeppel F. PMID: 14599218.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    121. Synthesis of functionally diverse and conformationally constrained polycyclic analogues of proline and prolinol. J Org Chem. 2003 Sep 19; 68(19):7204-18. Hanessian S, Papeo G, Angiolini M, Fettis K, Beretta M, Munro A. PMID: 12968869.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    122. Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation. J Org Chem. 2003 Sep 19; 68(19):7219-33. Hanessian S, Sailes H, Munro A, Therrien E. PMID: 12968870.
      View in: PubMed   Mentions: 1     Fields:    
    123. Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate. Eur J Neurosci. 2003 Sep; 18(6):1507-17. Jourquin J, Tremblay E, Décanis N, Charton G, Hanessian S, Chollet AM, Le Diguardher T, Khrestchatisky M, Rivera S. PMID: 14511330.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    124. Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells. J Med Chem. 2003 Aug 14; 46(17):3600-11. Hanessian S, Zhan L, Bovey R, Saavedra OM, Juillerat-Jeanneret L. PMID: 12904064.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    125. The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. J Med Chem. 2003 Jan 02; 46(1):34-48. Hanessian S, Parthasarathy S, Mauduit M, Payza K. PMID: 12502358.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    126. Design, synthesis, and neuraminidase inhibitory activity of GS-4071 analogues that utilize a novel hydrophobic paradigm. Bioorg Med Chem Lett. 2002 Dec 02; 12(23):3425-9. Hanessian S, Wang J, Montgomery D, Stoll V, Stewart KD, Kati W, Maring C, Kempf D, Hutchins C, Laver WG. PMID: 12419376.
      View in: PubMed   Mentions: 2     Fields:    
    127. Total synthesis and structural confirmation of the marine natural product Dysinosin A: a novel inhibitor of thrombin and Factor VIIa. J Am Chem Soc. 2002 Nov 13; 124(45):13342-3. Hanessian S, Margarita R, Hall A, Johnstone S, Tremblay M, Parlanti L. PMID: 12418860.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    128. Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones. Bioorg Med Chem Lett. 2002 Oct 21; 12(20):2907-11. Hanessian S, Therrien E, Granberg K, Nilsson I. PMID: 12270173.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    129. The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor. J Org Chem. 2002 Jun 14; 67(12):4261-74. Hanessian S, Claridge S, Johnstone S. PMID: 12054962.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    130. Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics. J Org Chem. 2002 May 17; 67(10):3387-97. Hanessian S, Buckle R, Bayrakdarian M. PMID: 12003550.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    131. Synthesis of a potent antagonist of E-selectin. J Org Chem. 2002 May 17; 67(10):3346-54. Hanessian S, Mascitti V, Rogel O. PMID: 12003545.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    132. Total synthesis of A-315675: a potent inhibitor of influenza neuraminidase. J Am Chem Soc. 2002 May 01; 124(17):4716-21. Hanessian S, Bayrakdarian M, Luo X. PMID: 11971721.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    133. Conformationally stable and constrained macrocarbocyclic pseudopeptide mimics of beta-hairpin structures. Chemistry. 2002 Jan 04; 8(1):111-7. Hanessian S, Angiolini M. PMID: 11822444.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    134. Total synthesis of bafilomycin A(1) relying on iterative 1,2-induction in acyclic precursors. J Am Chem Soc. 2001 Oct 24; 123(42):10200-6. Hanessian S, Ma J, Wang W, Gai Y. PMID: 11603969.
      View in: PubMed   Mentions: 3     Fields:    
    135. Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3810-3813. Hanessian S, Mauduit M. PMID: 29712134.
      View in: PubMed   Mentions:    Fields:    
    136. Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics We thank the NSERC of Canada for financial support through the Medicinal Chemistry Chair program. We thank Dr. Michel Simard for the X-ray crystal structure determinations. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3810-3813. Hanessian S, Mauduit M. PMID: 11668540.
      View in: PubMed   Mentions: 2     Fields:    
    137. A comparative docking study and the design of potentially selective MMP inhibitors. J Comput Aided Mol Des. 2001 Oct; 15(10):873-81. Hanessian S, Moitessier N, Therrien E. PMID: 11918074.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    138. N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets. J Med Chem. 2001 Sep 13; 44(19):3066-73. Hanessian S, Moitessier N, Gauchet C, Viau M. PMID: 11543675.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    139. Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S(1) pocket using conformationally constrained inhibitors. J Med Chem. 2001 Sep 13; 44(19):3074-82. Hanessian S, MacKay DB, Moitessier N. PMID: 11543676.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    140. Stereocontrolled glycosyl transfer reactions with unprotected glycosyl donors. Chem Rev. 2000 Dec 13; 100(12):4443-64. Hanessian S, Lou B. PMID: 11749354.
      View in: PubMed   Mentions: 17     Fields:    
    141. Catalytic asymmetric conjugate addition of nitroalkanes to cycloalkenones. Org Lett. 2000 Sep 21; 2(19):2975-8. Hanessian S, Pham V. PMID: 10986086.
      View in: PubMed   Mentions: 1     Fields:    
    142. Asymmetric synthesis of functionalized carbocycles and heterocycles. Chirality. 2000 Jun; 12(5-6):342-5. Hanessian S, Griffin AM, Cantin LD. PMID: 10824149.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    143. Pyrrolidine as a cogwheel-like scaffold for the deployment of diverse functionality through cycloaddition reactions of metallo-1,3-dipoles in aqueous media. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):427-31. Hanessian S, Bayrakdarian M. PMID: 10743941.
      View in: PubMed   Mentions:    Fields:    
    144. Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):439-42. Hanessian S, Saavedra OM, Xie F, Amboldi N, Battistini C. PMID: 10743943.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    145. Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):433-7. Hanessian S, Sgarbi PW. PMID: 10743942.
      View in: PubMed   Mentions: 3     Fields:    
    146. Exploring the chiral space within the active site of alpha-thrombin with a constrained mimic of D-Phe-Pro-Arg--design, synthesis, inhibitory activity, and X-ray structure of an enzyme-inhibitor complex. Bioorg Med Chem Lett. 2000 Feb 07; 10(3):243-7. Hanessian S, Balaux E, Musil D, Olsson LL, Nilsson I. PMID: 10698445.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    147. Synthesis of a phostone glycomimetic of the endothelin converting enzyme inhibitor phosphoramidon. Bioorg Med Chem Lett. 1999 Aug 16; 9(16):2441-6. Hanessian S, Rogel O. PMID: 10476884.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    148. Total Synthesis and Absolute Configuration of (-)-Anthoplalone. J Org Chem. 1999 Jun 25; 64(13):4893-4900. Hanessian S, Cantin LD, Andreotti D. PMID: 11674567.
      View in: PubMed   Mentions: 1     Fields:    
    149. Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. Bioorg Med Chem Lett. 1999 Jun 21; 9(12):1691-6. Hanessian S, Bouzbouz S, Boudon A, Tucker GC, Peyroulan D. PMID: 10397503.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    150. Asymmetric synthesis of L-azetidine-2-carboxylic acid and 3-substituted congeners--conformationally constrained analogs of phenylalanine, naphthylalanine, and leucine. Bioorg Med Chem Lett. 1999 May 17; 9(10):1437-42. Hanessian S, Bernstein N, Yang RY, Maguire R. PMID: 10360752.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    151. Synthesis of a versatile peptidomimetic scaffold. Methods Mol Med. 1999; 23:161-74. Hanessian S, McNaughton-Smith G. PMID: 21380897.
      View in: PubMed   Mentions: 1     Fields:    
    152. Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin. Bioorg Med Chem Lett. 1998 Oct 06; 8(19):2803-8. Hanessian S, Huynh HK, Reddy GV, McNaughton-Smith G, Ernst B, Kolb HC, Magnani J, Sweeley C. PMID: 9873626.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    153. Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity. Bioorg Med Chem Lett. 1998 Aug 18; 8(16):2123-8. Hanessian S, Reinhold U, Saulnier M, Claridge S. PMID: 9873498.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    154. trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular Recognition. Chem Rev. 1997 Dec 18; 97(8):3161-3196. Bennani YL, Hanessian S. PMID: 11851488.
      View in: PubMed   Mentions: 13     Fields:    
    155. Total Synthesis of (-)-Reserpine Using the Chiron Approach. J Org Chem. 1997 Feb 07; 62(3):465-473. Hanessian S, Pan J, Carnell A, Bouchard H, Lesage L. PMID: 11671435.
      View in: PubMed   Mentions: 2     Fields:    
    156. Synthesis of 4-amino-4(S)-dihydrospectinomycin. J Antibiot (Tokyo). 1981 Mar; 34(3):350-2. Hanessian S, Roy R, Therien M, Delorme D. PMID: 6456250.
      View in: PubMed   Mentions:    Fields:    
    157. Aminoglycoside antibiotics 4'-deoxyneomycin and 4'-deoxyparomamine. J Antibiot (Tokyo). 1980 Jun; 33(6):675-8. Hanessian S, Vatele JM. PMID: 7419479.
      View in: PubMed   Mentions:    Fields:    
    158. Studies directed toward the total synthesis of antibiotics: (+)-spectinomycin. Jpn J Antibiot. 1979 Dec; 32 Suppl:S73-90. Hanessian S, Roy R. PMID: 162067.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    159. Aminoglycoside antibiotics: synthesis of 5''-amino-5''-deoxyneomycin and 5''-amino-5''-deoxyparomomycin. J Antibiot (Tokyo). 1977 Oct; 30(10):893-6. Hanessian S, Massé R, Capmeau ML. PMID: 591451.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    160. Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin. J Med Chem. 1976 Dec; 19(12):1424-5. Arcamone F, Penco S, Redaelli S, Hanessian S. PMID: 1003430.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    161. Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines. J Med Chem. 1976 May; 19(5):733-4. Arcamone F, Bargiotii A, Cassinelli G, Redaelli S, Hanessian S, Di Marco A, Casazza AM, Dasdia T, Necco A, Reggiani P, Supino R. PMID: 1271420.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    162. Synthesis of a configurational analog of daunorubicin. Carbohydr Res. 1976 Feb; 46(2):C3-5. Arcamone F, Bargiotti A, Cassinelli G, Penco S, Hanessian S. PMID: 1260787.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    163. Synthesis of naturally occurring C-nucleosides, their analogs, and functionalized C-glycosyl precursors. Adv Carbohydr Chem Biochem. 1976; 33:111-88. Hanessian S, Pernet AG. PMID: 793324.
      View in: PubMed   Mentions: 3     Fields:    
    164. Aminoglycoside antibiotics: oxidative degradations leading to novel biochemical probes and synthetic intermediates. J Antibiot (Tokyo). 1975 Oct; 28(10):835-7. Hanessian S, Takamoto T, Masse R. PMID: 1184474.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    165. Synthetic approaches to kasugamine. Carbohydr Res. 1974 Jul; 35(1):175-85. Hanessian S, Masse R. PMID: 4854593.
      View in: PubMed   Mentions:    Fields:    
    166. The N6-(dimethylamino)methylene derivative of 9-beta-D-arabinofuranosyladenine as an antiviral agent. J Med Chem. 1973 Mar; 16(3):290-2. Hanessian S. PMID: 4354694.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    167. Aminoglycoside antibiotics: chemical transformation of paromamine into 3'-epiparomamine. Carbohydr Res. 1973 Jan; 26(1):261-3. Hanessian S, Butterworth RF, Nakagawa T. PMID: 4696789.
      View in: PubMed   Mentions:    Fields:    
    168. Synthesis of 6-amino-6-deoxy- , -trehalose: a positional isomer of trehalosamine. J Antibiot (Tokyo). 1972 Nov; 25(11):683-4. Hanessian S, Lavallee P. PMID: 4647840.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    169. Isolation and characterization of antigenic components of a new heptavalent Pseudomonas vaccine. Nat New Biol. 1971 Feb 17; 229(7):209-10. Hanessian S, Regan W, Watson D, Haskell TH. PMID: 5281014.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    170. Mass spectrometry in the detemination of structure of certain natural products containing sugars. Methods Biochem Anal. 1971; 19:105-228. Hanessian S. PMID: 4935450.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    171. Synthetic penicillins derived from cycloheptatrienecarboxylic acids. J Med Chem. 1969 May; 12(3):527-9. Hanessian S, Schütze G. PMID: 5788175.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    172. Synthetic penicillins derived from benznorcaradienecarboxylic acids. J Med Chem. 1969 May; 12(3):529-31. Hanessian S, Schütze G. PMID: 4892245.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    173. Synthesis of DL-2-(2,4,6-cycloheptatrien-1-yl)glycine. J Med Chem. 1969 Mar; 12(2):347. Hanessian S, Schütze G. PMID: 5783621.
      View in: PubMed   Mentions:    Fields:    
    174. Mass spectrometric studies on aminocyclitol antibiotics. J Am Chem Soc. 1967 Jun 21; 89(13):3364-5. DeJongh DC, Hribar JD, Hanessian S, Woo PW. PMID: 6042775.
      View in: PubMed   Mentions: 1     Fields:    
    175. Selective hydrolysis of amide bonds in acetamido deoxy sugars. O-ethyl acetamidium fluoroborates. Tetrahedron Lett. 1967 Apr; 16:1549-52. Hanessian S. PMID: 6042551.
      View in: PubMed   Mentions: 1     Fields:    
    176. Further evidence on the structure of cordycepin. Biochim Biophys Acta. 1966 Apr 25; 117(2):480-2. Hanessian S, DeJongh DC, McCloskey JA. PMID: 5961310.
      View in: PubMed   Mentions: 2     Fields:    
    177. Deoxy sugars. Adv Carbohydr Chem Biochem. 1966; 21:143-207. Hanessian S. PMID: 4890108.
      View in: PubMed   Mentions: 5     Fields:    
    178. CHARACTERIZATION OF AMINO SUGARS BY MASS SPECTROMETRY. J Am Chem Soc. 1965 Aug 20; 87:3744-51. DEJONGH DC, HANESSIAN S. PMID: 14338113.
      View in: PubMed   Mentions: 1     Fields:    
    179. Reductive rearrangement of 5-azido-5-deoxy-pentoses. A new synthesis of sugars containing nitrogen in the ring. Chem Ind. 1965 Jul 17; 29:1296-7. Hanessian S. PMID: 5841771.
      View in: PubMed   Mentions:    Fields:    
    180. STRUCTURAL STUDIES ON STAPHYLOCOCCAL POLYSACCHARIDE ANTIGEN. J Biol Chem. 1964 Sep; 239:2758-64. HANESSIAN S, HASKELL TH. PMID: 14217874.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    181. THE PURIFICATION AND CHARACTERIZATION OF A NEW ACTIVE IMMUNIZING POLYSACCHARIDE PREPARED FROM STAPHYLOCOCCUS AUREUS. Biochim Biophys Acta. 1964 Mar 02; 83:35-41. HASKELL TH, HANESSIAN S. PMID: 14152196.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    182. 2-AMINO-2-ISOXY-D-GLUCURONIC ACID, THE MAIN CONSTITUENT OF SPA (STAPHYLOCOCCAL POLYSACCHARIDE ANTIGEN). Nature. 1963 Sep 14; 199:1075-6. HASKELL TH, HANESSIAN S. PMID: 14066943.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    Stephen's Networks
    Concepts (530)
    Derived automatically from this person's publications.
    _
    Co-Authors (1)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _