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Pseudodiproline (Pro-Cyp) Oligomers Fold into Helical Polyproline Type secondary structures. J Org Chem. 2024 Mar 15.
Garsi JB, Aguiar PM, Berger G, Maris T, Hanessian S. PMID: 38489026.
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PubMed Mentions: Fields:
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Synthesis of Aza-Bridged Perhydroazulene Chimeras of Tropanes and Hederacine A. J Org Chem. 2023 Apr 07; 88(7):4675-4686.
Hocine S, Duchamp E, Mishra A, Fourquez JM, Hanessian S. PMID: 36940388.
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PubMed Mentions:
1 Fields:
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Systematic Investigation of Tether Length and Phosphorus Configuration in Backbone Constrained Macrocyclic Nucleic Acids to Modulate Binding Kinetics for RNA. J Org Chem. 2023 03 17; 88(6):3599-3614.
Rajasekaran T, Freestone GC, Galindo-Murillo R, Lugato B, Gaus H, Migawa MT, Swayze EE, Cheatham TE, Seth PP, Hanessian S. PMID: 36857642.
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PubMed Mentions: Fields:
Translation:
Cells
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Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics. Nucleic Acids Res. 2023 02 28; 51(4):1583-1599.
Finicle BT, Eckenstein KH, Revenko AS, Anderson BA, Wan WB, McCracken AN, Gil D, Fruman DA, Hanessian S, Seth PP, Edinger AL. PMID: 36727438; PMCID: PMC9976930.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Polygonapholine: A Total Synthesis Questions the Identity for the Purported Structure of the Natural Product. J Org Chem. 2022 Nov 18; 87(22):15713-15718.
Duchamp E, Devin R, Aguiar PM, Gaucherand A, Hanessian S. PMID: 36349937.
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PubMed Mentions: Fields:
Translation:
Cells
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Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25. Bioorg Med Chem Lett. 2022 11 01; 75:128950.
Kiyeleko S, Hocine S, Mautino G, Kuenemann M, Nawrotek A, Miallau L, Vuillard LM, Mirguet O, Kotschy A, Hanessian S. PMID: 36030002.
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Translation:
Humans
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2-Oxa-5-azabicyclo[2.2.1]heptane as a Platform for Functional Diversity: Synthesis of Backbone-Constrained γ-Amino Acid Analogues. J Org Chem. 2022 08 19; 87(16):11261-11273.
Garsi JB, Guggari S, Deis T, Ma M, Hocine S, Hanessian S. PMID: 35900070.
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PubMed Mentions: Fields:
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Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics. ACS Med Chem Lett. 2022 Jun 09; 13(6):949-954.
Garsi JB, Komjáti B, Cullia G, Fejes I, Sipos M, Sipos Z, Fördos E, Markacz P, Balázs B, Lancelot N, Berger S, Raimbaud E, Brown D, Vuillard LM, Haberkorn L, Cukier C, Szlávik Z, Hanessian S. PMID: 35707140; PMCID: PMC9190036.
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PubMed Mentions:
2
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Surprising Chemistry of 6-Azidotetrazolo[5,1-a]phthalazine: What a Purported Natural Product Reveals about the Polymorphism of Explosives. J Org Chem. 2022 05 20; 87(10):6680-6694.
Nunez Avila AG, Deschênes-Simard B, Arnold JE, Morency M, Chartrand D, Maris T, Berger G, Day GM, Hanessian S, Wuest JD. PMID: 35504046.
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PubMed Mentions: Fields:
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Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA. J Am Chem Soc. 2022 02 02; 144(4):1941-1950.
Rajasekaran T, Freestone GC, Galindo-Murillo R, Lugato B, Rico L, Salinas JC, Gaus H, Migawa MT, Swayze EE, Cheatham TE, Hanessian S, Seth PP. PMID: 35041415; PMCID: PMC9527079.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Computational and Further Experimental Explorations of the Competing Cascades Following Claisen Rearrangements of Aryl Propargyl Ethers: Substituent Effects on Reactivity and Regioselectivity. J Org Chem. 2021 Dec 17; 86(24):17955-17964.
Ramirez M, Vece V, Hanessian S, Houk KN. PMID: 34846894.
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PubMed Mentions: Fields:
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Design of Pseudodiproline Dimers as Mimetics of Pro-Pro Units: Stereocontrolled Synthesis, Configurational Relevance, and Structural Properties. J Org Chem. 2021 12 03; 86(23):16834-16847.
Garsi JB, Aguiar PM, Hanessian S. PMID: 34749500.
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PubMed Mentions:
1 Fields:
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Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. EMBO Mol Med. 2021 08 09; 13(8):e13086.
Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. PMID: 34231322; PMCID: PMC8350895.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Cyanide-Free Synthesis of Air Stable N-Substituted Li and K Cyanamide Salts from Tetrazoles. Applications toward the Synthesis of Primary and Secondary Cyanamides as Precursors to Amidines. Org Lett. 2020 Nov 06; 22(21):8487-8491.
Duchamp E, Hanessian S. PMID: 33090802.
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PubMed Mentions: Fields:
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Ni-Catalyzed Reductive and Merged Photocatalytic Cross-Coupling Reactions toward sp3/sp2-Functionalized Isoquinolones: Creating Diversity at C-6 and C-7 to Address Bioactive Analogues. ACS Omega. 2020 Oct 27; 5(42):27591-27606.
Dumas A, Garsi JB, Poissonnet G, Hanessian S. PMID: 33134723; PMCID: PMC7594327.
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PubMed Mentions:
2
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Total Synthesis and Stereochemical Confirmation of (-)-Olivil, (+)-Cycloolivil, (-)-Alashinols F and G, (+)-Cephafortin A, and Their Congeners: Filling in Biosynthetic Gaps. Org Lett. 2020 05 01; 22(9):3345-3350.
Reddy Vakiti J, Hanessian S. PMID: 32293189.
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PubMed Mentions:
3 Fields:
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Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras. J Org Chem. 2020 03 20; 85(6):4237-4247.
Hocine S, Berger G, Hanessian S. PMID: 32134267.
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PubMed Mentions:
3 Fields:
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Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines. ACS Med Chem Lett. 2020 May 14; 11(5):686-690.
Bachollet SPJT, Vece V, McCracken AN, Finicle BT, Selwan E, Ben Romdhane N, Dahal A, Ramirez C, Edinger AL, Hanessian S. PMID: 32435371; PMCID: PMC7236038.
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PubMed Mentions:
2
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Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs. Nucleosides Nucleotides Nucleic Acids. 2020; 39(1-3):384-406.
Salinas JC, Seth PP, Hanessian S. PMID: 31380707.
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PubMed Mentions: Fields:
Translation:
Cells
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Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A. Bioorg Med Chem Lett. 2019 09 15; 29(18):2681-2685.
Garsi JB, Vece V, Sernissi L, Auger-Morin C, Hanessian S, McCracken AN, Selwan E, Ramirez C, Dahal A, Romdhane NB, Finicle BT, Edinger AL. PMID: 31383588; PMCID: PMC7784717.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines. Org Lett. 2019 09 06; 21(17):6593-6596.
Duchamp E, Simard BD, Hanessian S. PMID: 31240939.
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PubMed Mentions:
1 Fields:
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Synthesis of 1',2'-methano-2',3'-dideoxynucleosides as potential antivirals. Bioorg Med Chem Lett. 2019 02 15; 29(4):597-600.
Rico L, Hanessian S. PMID: 30612845.
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Translation:
HumansCells
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Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs. Mol Cell Proteomics. 2019 03; 18(3):408-422.
Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault P. PMID: 30482847; PMCID: PMC6398214.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways. Eur J Med Chem. 2018 Nov 05; 159:217-242.
Garsi JB, Sernissi L, Vece V, Hanessian S, McCracken AN, Simitian G, Edinger AL. PMID: 30292898; PMCID: PMC6217821.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Conception and Synthesis of Oxabicyclic Nucleoside Phosphonates as Internucleotidic Phosphate Surrogates in Antisense Oligonucleotide Constructs. Org Lett. 2018 09 07; 20(17):5296-5299.
Salinas JC, Yu J, Østergaard M, Seth PP, Hanessian S. PMID: 30146887.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Total Synthesis and Absolute Stereochemical Assignment of the Insecticidal Metabolites Yaequinolones J1 and J2. Org Lett. 2018 07 20; 20(14):4277-4280.
Vece V, Jakkepally S, Hanessian S. PMID: 29975546.
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PubMed Mentions:
5 Fields:
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Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside. ChemMedChem. 2018 08 10; 13(15):1541-1548.
Kanazawa H, Saavedra OM, Maianti JP, Young SA, Izquierdo L, Smith TK, Hanessian S, Kondo J. PMID: 29766661.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Design and synthesis of bridged piperidine and piperazine isosteres. Bioorg Med Chem Lett. 2018 08 15; 28(15):2627-2630.
Maertens G, Saavedra OM, Vece V, Reyes MAV, Hocine S, Öney E, Goument B, Mirguet O, Le Tiran A, Gloanec P, Hanessian S. PMID: 29937060.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma. Bioorg Med Chem Lett. 2018 08 15; 28(15):2652-2654.
Rico L, Østergaard ME, Bell M, Seth PP, Hanessian S. PMID: 30042045.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Recent Progress in the Chemistry of Daphniphyllum Alkaloids †. Chem Rev. 2017 Mar 08; 117(5):4104-4146.
Chattopadhyay AK, Hanessian S. PMID: 28205435.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors. Bioorg Med Chem. 2017 01 01; 25(1):38-52.
Saavedra OM, Karila D, Brossard D, Rojas A, Dupuis D, Gohier A, Mannoury la Cour C, Millan MJ, Ortuno JC, Hanessian S. PMID: 28029458.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. 2016 11 01; 126(11):4088-4102.
Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL. PMID: 27669461; PMCID: PMC5096903.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia. 2017 03; 31(3):669-677.
McCracken AN, McMonigle RJ, Tessier J, Fransson R, Perryman MS, Chen B, Keebaugh A, Selwan E, Barr SA, Kim SM, Roy SG, Liu G, Fallegger D, Sernissi L, Brandt C, Moitessier N, Snider AJ, Clare S, Müschen M, Huwiler A, Kleinman MT, Hanessian S, Edinger AL. PMID: 27573555; PMCID: PMC5332311.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death. Bioorg Med Chem. 2016 09 15; 24(18):4390-4397.
Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S. PMID: 27475534.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Solution and Solid-Phase Stereocontrolled Synthesis of 1,2-cis-Glycopyranosides with Minimally Protected Glycopyranosyl Donors Catalyzed by BF3-N,N-Dimethylformamide Complex. Org Lett. 2016 07 01; 18(13):3106-9.
St-Pierre G, Hanessian S. PMID: 27301355.
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PubMed Mentions:
1 Fields:
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Strategies toward the Total Synthesis of Calyciphylline B-type Alkaloids: A Computational Perspective Aided by DFT Analysis. J Org Chem. 2016 06 17; 81(12):5074-86.
Chattopadhyay AK, Berger G, Hanessian S. PMID: 27251014.
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PubMed Mentions:
1 Fields:
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Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs. Bioorg Med Chem. 2016 06 01; 24(11):2397-2409.
St-Pierre G, Pal S, Østergaard ME, Zhou T, Yu J, Tanowitz M, Seth PP, Hanessian S. PMID: 27117693.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Synthesis of a Model Tetracyclic Core Structure of Calyciphylline B-Type Alkaloids. J Org Chem. 2016 Mar 04; 81(5):2182-8.
Chattopadhyay AK, Menz H, Ly VL, Dorich S, Hanessian S. PMID: 26878089.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Design, synthesis, and duplex-stabilizing properties of conformationally constrained tricyclic analogues of LNA. Org Biomol Chem. 2016 Feb 14; 14(6):2034-40.
Giacometti RD, Salinas JC, Østergaard ME, Swayze EE, Seth PP, Hanessian S. PMID: 26765794.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms. Angew Chem Int Ed Engl. 2016 Mar 18; 55(13):4156-86.
Büschleb M, Dorich S, Hanessian S, Tao D, Schenthal KB, Overman LE. PMID: 26836448; PMCID: PMC4865016.
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PubMed Mentions:
51 Fields:
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Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum. Angew Chem Int Ed Engl. 2016 Feb 12; 55(7):2577-81.
Chattopadhyay AK, Ly VL, Jakkepally S, Berger G, Hanessian S. PMID: 26765928.
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PubMed Mentions:
4 Fields:
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Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes. ACS Med Chem Lett. 2016 Jan 14; 7(1):6-9.
Hanessian S. PMID: 26819656; PMCID: PMC4716587.
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Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo. ACS Chem Biol. 2016 Feb 19; 11(2):409-14.
Chen B, Roy SG, McMonigle RJ, Keebaugh A, McCracken AN, Selwan E, Fransson R, Fallegger D, Huwiler A, Kleinman MT, Edinger AL, Hanessian S. PMID: 26653336; PMCID: PMC4862402.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Cyclic enaminones. Part I: stereocontrolled synthesis using diastereoselective and catalytic asymmetric methods. Chem Commun (Camb). 2015 Nov 28; 51(92):16437-49.
Chattopadhyay AK, Hanessian S. PMID: 26490402.
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PubMed Mentions:
5 Fields:
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Cyclic enaminones. Part II: applications as versatile intermediates in alkaloid synthesis. Chem Commun (Camb). 2015 Nov 28; 51(92):16450-67.
Chattopadhyay AK, Hanessian S. PMID: 26490499.
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PubMed Mentions:
7 Fields:
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Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano-L-Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer. Angew Chem Int Ed Engl. 2015 Nov 02; 54(45):13268-72.
Berger G, Vilchis-Reyes M, Hanessian S. PMID: 26346999.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences. J Org Chem. 2014 Dec 05; 79(23):11651-60.
Salinas JC, Migawa MT, Merner BL, Hanessian S. PMID: 25401196.
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PubMed Mentions: Fields:
Translation:
Cells
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Conception and evolution of stereocontrolled strategies toward functionalized 8-aryloctanoic acids related to the total synthesis of aliskiren. J Org Chem. 2014 Oct 17; 79(20):9531-45.
Hanessian S, Chénard E, Guesné S, Cusson JP. PMID: 25285791.
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PubMed Mentions: Fields:
Translation:
Cells
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Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules. Beilstein J Org Chem. 2014; 10:1848-77.
Focken T, Hanessian S. PMID: 25246946; PMCID: PMC4168934.
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Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs. ACS Chem Biol. 2014 Sep 19; 9(9):2067-73.
Maianti JP, Kanazawa H, Dozzo P, Matias RD, Feeney LA, Armstrong ES, Hildebrandt DJ, Kane TR, Gliedt MJ, Goldblum AA, Linsell MS, Aggen JB, Kondo J, Hanessian S. PMID: 25019242.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Kinetic diastereomer differentiation in Au(III)- and Bi(III)-catalyzed benzylic arylation: concise and stereocontrolled synthesis of 2-amino-1,1-diarylalkanes. Org Lett. 2014 May 16; 16(10):2668-71.
Chénard E, Hanessian S. PMID: 24805004.
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PubMed Mentions: Fields:
Translation:
Cells
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Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists. ACS Med Chem Lett. 2014 May 08; 5(5):550-5.
Hanessian S, Jennequin T, Boyer N, Babonneau V, Soma U, Mannoury la Cour C, Millan MJ, De Nanteuil G. PMID: 24900878; PMCID: PMC4027792.
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PubMed Mentions:
3
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Iminium ion-enamine cascade cyclizations: facile access to structurally diverse azacyclic compounds and natural products. Org Lett. 2014 Jan 03; 16(1):232-5.
Hanessian S, Chattopadhyay AK. PMID: 24341416.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Design and synthesis of potential dual NK(1)/NK(3) receptor antagonists. Bioorg Med Chem Lett. 2014 Jan 15; 24(2):510-4.
Hanessian S, Babonneau V, Boyer N, Mannoury la Cour C, Millan MJ, De Nanteuil G. PMID: 24374277.
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PubMed Mentions:
3 Fields:
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Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). ACS Med Chem Lett. 2013 Oct 10; 4(10).
Fransson R, McCracken AN, Chen B, McMonigle RJ, Edinger AL, Hanessian S. PMID: 24273632; PMCID: PMC3834958.
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PubMed Mentions:
7
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A constrained tricyclic nucleic acid analogue of α-L-LNA: investigating the effects of dual conformational restriction on duplex thermal stability. J Org Chem. 2013 Sep 20; 78(18):9064-75.
Hanessian S, Wagger J, Merner BL, Giacometti RD, Ostergaard ME, Swayze EE, Seth PP. PMID: 23937256.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Synthesis of cis- and trans-α-l-[4.3.0]bicyclo-DNA monomers for antisense technology: methods for the diastereoselective formation of bicyclic nucleosides. J Org Chem. 2013 Sep 20; 78(18):9051-63.
Hanessian S, Schroeder BR, Merner BL, Chen B, Swayze EE, Seth PP. PMID: 23937280.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Studies toward the generation of functionalized quaternary carbon centers relying on Wittig and Wittig-Still allylic ether anionic transpositions. J Org Chem. 2013 Sep 06; 78(17):8915-21.
Hanessian S, Dorich S, Chattopadhyay AK, Büschleb M. PMID: 23915281.
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PubMed Mentions: Fields:
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Concise and stereocontrolled synthesis of the tetracyclic core of daphniglaucin C. Org Lett. 2013 Aug 16; 15(16):4134-7.
Hanessian S, Dorich S, Menz H. PMID: 23889206.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Crystal structure of a bioactive pactamycin analog bound to the 30S ribosomal subunit. J Mol Biol. 2013 Oct 23; 425(20):3907-10.
Tourigny DS, Fernández IS, Kelley AC, Vakiti RR, Chattopadhyay AK, Dorich S, Hanessian S, Ramakrishnan V. PMID: 23702293; PMCID: PMC3794158.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites. ChemMedChem. 2013 May; 8(5):733-9.
Kondo J, Koganei M, Maianti JP, Ly VL, Hanessian S. PMID: 23436717.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Probing functional diversity in pactamycin toward antibiotic, antitumor, and antiprotozoal activity. Bioorg Med Chem. 2013 Apr 01; 21(7):1775-86.
Hanessian S, Vakiti RR, Chattopadhyay AK, Dorich S, Lavallée C. PMID: 23434136.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Total synthesis of pactamycin and pactamycate: a detailed account. J Org Chem. 2012 Nov 02; 77(21):9458-72.
Hanessian S, Vakiti RR, Dorich S, Banerjee S, Deschênes-Simard B. PMID: 23083207.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Structure-based design of a highly constrained nucleic acid analogue: improved duplex stabilization by restricting sugar pucker and torsion angle γ. Angew Chem Int Ed Engl. 2012 Nov 05; 51(45):11242-5.
Hanessian S, Schroeder BR, Giacometti RD, Merner BL, Ostergaard M, Swayze EE, Seth PP. PMID: 22915274.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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The enterprise of synthesis: from concept to practice. J Org Chem. 2012 Aug 17; 77(16):6657-88.
Hanessian S. PMID: 22784216.
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PubMed Mentions:
6 Fields:
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A new approach to the synthesis of peptidomimetic renin inhibitors: palladium-catalyzed asymmetric allylation of acyclic alkyl aryl ketones. Org Lett. 2012 Jun 15; 14(12):3222-5.
Hanessian S, Chénard E. PMID: 22668074.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation. Org Lett. 2011 Dec 16; 13(24):6476-9.
Hanessian S, Maianti JP, Matias RD, Feeney LA, Armstrong ES. PMID: 22085292.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue. ACS Med Chem Lett. 2011 Dec 08; 2(12):924-8.
Hanessian S, Giguère A, Grzyb J, Maianti JP, Saavedra OM, Aggen JB, Linsell MS, Goldblum AA, Hildebrandt DJ, Kane TR, Dozzo P, Gliedt MJ, Matias RD, Feeney LA, Armstrong ES. PMID: 24900282; PMCID: PMC4018147.
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PubMed Mentions:
7
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Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues. ChemMedChem. 2011 Nov 04; 6(11):1961-6.
Szychowski J, Kondo J, Zahr O, Auclair K, Westhof E, Hanessian S, Keillor JW. PMID: 21905229; PMCID: PMC5179253.
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PubMed Mentions:
15 Fields:
Translation:
Cells
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Total synthesis of pactamycin. Angew Chem Int Ed Engl. 2011 Apr 04; 50(15):3497-500.
Hanessian S, Vakiti RR, Dorich S, Banerjee S, Lecomte F, DelValle JR, Zhang J, Deschênes-Simard B. PMID: 21370372.
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PubMed Mentions:
19 Fields:
-
Total synthesis of (+)-ent-cyclizidine: absolute configurational confirmation of antibiotic M146791. Org Lett. 2011 Mar 04; 13(5):1048-51.
Hanessian S, Soma U, Dorich S, Deschênes-Simard B. PMID: 21271743.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Applications of organocatalytic asymmetric synthesis to drug prototypes--dual action and selective inhibitors of n-nitric oxide synthase with activity against the 5-HT1D/1B subreceptors. Org Lett. 2011 Mar 04; 13(5):840-3.
Hanessian S, Stoffman E, Mi X, Renton P. PMID: 21271688.
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PubMed Mentions:
1 Fields:
Translation:
Cells
-
Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. J Med Chem. 2010 Dec 09; 53(23):8387-99.
Auzzas L, Larsson A, Matera R, Baraldi A, Deschênes-Simard B, Giannini G, Cabri W, Battistuzzi G, Gallo G, Ciacci A, Vesci L, Pisano C, Hanessian S. PMID: 21073160.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. Bioorg Med Chem Lett. 2010 Dec 01; 20(23):6925-8.
Hanessian S, Larsson A, Fex T, Knecht W, Blomberg N. PMID: 21035339.
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PubMed Mentions:
8 Fields:
-
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria. Bioorg Med Chem Lett. 2010 Dec 01; 20(23):7097-101.
Hanessian S, Pachamuthu K, Szychowski J, Giguère A, Swayze EE, Migawa MT, François B, Kondo J, Westhof E. PMID: 20970332.
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PubMed Mentions:
11 Fields:
Translation:
Cells
-
Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit. J Org Chem. 2010 Aug 20; 75(16):5601-18.
Hanessian S, Focken T, Mi X, Oza R, Chen B, Ritson D, Beaudegnies R. PMID: 20704433.
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PubMed Mentions:
6 Fields:
Translation:
Cells
-
Total synthesis of jerangolid A. Org Lett. 2010 Jul 16; 12(14):3172-5.
Hanessian S, Focken T, Oza R. PMID: 20565089.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics. J Org Chem. 2010 May 07; 75(9):2861-76.
Hanessian S, Maji DK, Govindan S, Matera R, Tintelnot-Blomley M. PMID: 20392053.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Total synthesis of "aliskiren": the first Renin inhibitor in clinical practice for hypertension. Org Lett. 2010 Apr 16; 12(8):1816-9.
Hanessian S, Guesné S, Chénard E. PMID: 20235519.
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PubMed Mentions:
2 Fields:
-
Vorinostat-like molecules as structural, stereochemical, and pharmacological tools. ACS Med Chem Lett. 2010 May 13; 1(2):70-4.
Hanessian S, Auzzas L, Larsson A, Zhang J, Giannini G, Gallo G, Ciacci A, Cabri W. PMID: 24900179; PMCID: PMC4007911.
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PubMed Mentions:
2
-
Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin. Chem Commun (Camb). 2010 Mar 28; 46(12):2013-5.
Hanessian S, Maianti JP. PMID: 20221476.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):1924-7.
Hanessian S, Shao Z, Betschart C, Rondeau JM, Neumann U, Tintelnot-Blomley M. PMID: 20172717.
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PubMed Mentions:
4 Fields:
Translation:
Cells
-
Total synthesis of oidiodendrolides and related norditerpene dilactones from a common precursor: metabolites CJ-14,445, LL-Z1271gamma, oidiolactones A, B, C, and D, and nagilactone F. Org Lett. 2009 Oct 15; 11(20):4640-3.
Hanessian S, Boyer N, Reddy GJ, Deschênes-Simard B. PMID: 19778011.
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PubMed Mentions:
5 Fields:
-
Total synthesis and structural revision of the presumed aeruginosins 205A and B. Org Lett. 2009 Sep 17; 11(18):4232-5.
Hanessian S, Wang X, Ersmark K, Del Valle JR, Klegraf E. PMID: 19691354.
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PubMed Mentions:
3 Fields:
Translation:
Cells
-
From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett. 2009 Sep 15; 19(18):5429-32.
Hanessian S, Therrien E, Zhang J, Otterlo Wv, Xue Y, Gustafsson D, Nilsson I, Fjellström O. PMID: 19674897.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Surface-functionalized ultrasmall superparamagnetic nanoparticles as magnetic delivery vectors for camptothecin. ChemMedChem. 2009 Jun; 4(6):988-97.
Cengelli F, Grzyb JA, Montoro A, Hofmann H, Hanessian S, Juillerat-Jeanneret L. PMID: 19347834.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans. Org Lett. 2009 Jan 15; 11(2):429-32.
Hanessian S, Szychowski J, Maianti JP. PMID: 19072132.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids. Acc Chem Res. 2008 Oct; 41(10):1241-51.
Hanessian S, Auzzas L. PMID: 18646869.
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PubMed Mentions:
11 Fields:
Translation:
Cells
-
Proximity-assisted cycloaddition reactions--facile Lewis acid-mediated synthesis of diversely functionalized bicyclic tetrazoles. Org Lett. 2008 Apr 03; 10(7):1381-4.
Hanessian S, Simard D, Deschênes-Simard B, Chenel C, Haak E. PMID: 18314995.
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PubMed Mentions:
1 Fields:
-
Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):1972-6.
Hanessian S, Simard D, Bayrakdarian M, Therrien E, Nilsson I, Fjellström O. PMID: 18289852.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Chemistry and biology of the aeruginosin family of serine protease inhibitors. Angew Chem Int Ed Engl. 2008; 47(7):1202-23.
Ersmark K, Del Valle JR, Hanessian S. PMID: 18076006.
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PubMed Mentions:
47 Fields:
Translation:
Cells
-
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs. Bioorg Med Chem. 2008 Mar 15; 16(6):2921-31.
Hanessian S, Grzyb JA, Cengelli F, Juillerat-Jeanneret L. PMID: 18226908.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Alternative and expedient asymmetric syntheses of L-(+)-noviose. Org Lett. 2008 Jan 17; 10(2):261-4.
Hanessian S, Auzzas L. PMID: 18081305.
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PubMed Mentions: Fields:
Translation:
Cells
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Targeting ACE and ECE with dual acting inhibitors. Bioorg Med Chem Lett. 2008 Feb 01; 18(3):1058-62.
Hanessian S, Guesné S, Riber L, Marin J, Benoist A, Mennecier P, Rupin A, Verbeuren TJ, De Nanteuil G. PMID: 18160283.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Self-assembly of noncyclic bis-D- and L-tripeptides into higher order tubular constructs: design, synthesis, and X-ray crystal superstructure. J Org Chem. 2008 Feb 15; 73(4):1181-91.
Hanessian S, Vinci V, Fettis K, Maris T, Viet MT. PMID: 18062697.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity. ChemMedChem. 2007 Nov; 2(11):1631-8.
Kondo J, Pachamuthu K, François B, Szychowski J, Hanessian S, Westhof E. PMID: 17722211.
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PubMed Mentions:
12 Fields:
Translation:
Cells
-
Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15; 17(22):6261-5.
Hanessian S, Auzzas L, Giannini G, Marzi M, Cabri W, Barbarino M, Vesci L, Pisano C. PMID: 17892933.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants. J Org Chem. 2007 Aug 17; 72(17):6353-63.
Loiseleur O, Ritson D, Nina M, Crowley P, Wagner T, Hanessian S. PMID: 17658846.
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PubMed Mentions:
2 Fields:
Translation:
Cells
-
Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin. J Med Chem. 2007 May 17; 50(10):2352-69.
Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. PMID: 17458946.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin. Bioorg Med Chem Lett. 2007 Jun 15; 17(12):3480-5.
Hanessian S, Ersmark K, Wang X, Del Valle JR, Blomberg N, Xue Y, Fjellström O. PMID: 17428662.
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PubMed Mentions:
6 Fields:
-
6-hydroxy to 6'''-amino tethered ring-to-ring macrocyclic aminoglycosides as probes for APH(3')-IIIa kinase. Bioorg Med Chem Lett. 2007 Jun 01; 17(11):3221-5.
Hanessian S, Szychowski J, Campos-Reales Pineda NB, Furtos A, Keillor JW. PMID: 17400454.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Structure-based organic synthesis of a tricyclic N-malayamycin analogue. J Org Chem. 2006 Dec 22; 71(26):9807-17.
Hanessian S, Ritson DJ. PMID: 17168600.
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PubMed Mentions: Fields:
Translation:
Cells
-
Structure-based organic synthesis of drug prototypes: a personal odyssey. ChemMedChem. 2006 Dec; 1(12):1301-30.
Hanessian S. PMID: 17091524.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Total synthesis and stereochemical confirmation of manassantin A, B, and B1. Org Lett. 2006 Nov 23; 8(24):5477-80.
Hanessian S, Reddy GJ, Chahal N. PMID: 17107051.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Efficient allyl to propenyl isomerization in functionally diverse compounds with a thermally modified Grubbs second-generation catalyst. Org Lett. 2006 Nov 23; 8(24):5481-4.
Hanessian S, Giroux S, Larsson A. PMID: 17107052.
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PubMed Mentions:
10 Fields:
-
Optimization of the catalytic asymmetric addition of nitroalkanes to cyclic enones with trans-4,5-methano-L-proline. Org Lett. 2006 Oct 12; 8(21):4787-90.
Hanessian S, Shao Z, Warrier JS. PMID: 17020303.
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PubMed Mentions: Fields:
Translation:
Cells
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Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):491-4.
Hanessian S, Charron G, Billich A, Guerini D. PMID: 17070046.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic beta-secretase (BACE 1) inhibitors. J Med Chem. 2006 Oct 05; 49(20):5885-94.
Moitessier N, Therrien E, Hanessian S. PMID: 17004704.
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PubMed Mentions:
12 Fields:
Translation:
Cells
-
Iterative synthesis of deoxypropionate units: the inductor effect in acyclic conformation design. J Org Chem. 2006 Sep 15; 71(19):7403-11.
Hanessian S, Chahal N, Giroux S. PMID: 16958535.
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PubMed Mentions:
3 Fields:
-
Matrix metalloproteinase-2 (MMP-2) regulates astrocyte motility in connection with the actin cytoskeleton and integrins. Glia. 2006 Sep; 54(4):272-84.
Ogier C, Bernard A, Chollet AM, LE Diguardher T, Hanessian S, Charton G, Khrestchatisky M, Rivera S. PMID: 16845676.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A. Org Lett. 2006 Aug 31; 8(18):4047-9.
Hanessian S, Mainetti E, Lecomte F. PMID: 16928070.
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PubMed Mentions:
2 Fields:
Translation:
Cells
-
Total synthesis and structural confirmation of chlorodysinosin A. J Am Chem Soc. 2006 Aug 16; 128(32):10491-5.
Hanessian S, Del Valle JR, Xue Y, Blomberg N. PMID: 16895415.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). J Med Chem. 2006 Jul 27; 49(15):4544-67.
Hanessian S, Yang G, Rondeau JM, Neumann U, Betschart C, Tintelnot-Blomley M. PMID: 16854060.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA. Bioorg Med Chem Lett. 2006 Sep 15; 16(18):4784-7.
Hanessian S, Vinci V, Auzzas L, Marzi M, Giannini G. PMID: 16870438.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme. J Org Chem. 2006 Mar 31; 71(7):2760-78.
Hanessian S, Gauchet C, Charron G, Marin J, Nakache P. PMID: 16555831.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Docking of aminoglycosides to hydrated and flexible RNA. J Med Chem. 2006 Feb 09; 49(3):1023-33.
Moitessier N, Westhof E, Hanessian S. PMID: 16451068.
View in:
PubMed Mentions:
30 Fields:
Translation:
Cells
-
Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):1032-6.
Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellström O, Xue Y. PMID: 16290930.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Natural products as scaffolds for chemical diversification: solution-phase parallel synthesis of a series of naringin analogues. J Comb Chem. 2005 Nov-Dec; 7(6):837-42.
Hanessian S, Kothakonda KK. PMID: 16283793.
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PubMed Mentions:
2 Fields:
-
Probing the "additive effect" in the proline and proline hydroxamic acid catalyzed asymmetric addition of nitroalkanes to cyclic enones. Chirality. 2005 Nov; 17(9):540-3.
Hanessian S, Govindan S, Warrier JS. PMID: 16189834.
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PubMed Mentions: Fields:
Translation:
Cells
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Man, machine and visual imagery in strategic synthesis planning: computer-perceived precursors for drug candidates. Curr Opin Drug Discov Devel. 2005 Nov; 8(6):798-819.
Hanessian S. PMID: 16312154.
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PubMed Mentions:
2 Fields:
-
3-N,N-Dimethylamino-3-deoxy lincomycin: a structure-based hybrid between lincomycin and the desosamine unit of erythromycin. Bioorg Med Chem. 2005 Sep 01; 13(17):5283-8.
Hanessian S, Kothakonda KK. PMID: 15994084.
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PubMed Mentions:
1 Fields:
-
Total synthesis and structural confirmation of (+)-longicin. Org Lett. 2005 Sep 01; 7(18):3989-92.
Hanessian S, Giroux S, Buffat M. PMID: 16119949.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Total synthesis of N-malayamycin A and related bicyclic purine and pyrimidine nucleosides. J Org Chem. 2005 Aug 19; 70(17):6721-34.
Hanessian S, Huang G, Chenel C, Machaalani R, Loiseleur O. PMID: 16095292.
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PubMed Mentions:
2 Fields:
-
Stereoselective synthesis of constrained oxacyclic hydroxyethylene isosteres of aspartic protease inhibitors: aldol and Mukaiyama aldol methodologies for branched tetrahydrofuran 2-carboxylic acids. J Org Chem. 2005 Aug 19; 70(17):6735-45.
Hanessian S, Hou Y, Bayrakdarian M, Tintelnot-Blomley M. PMID: 16095293.
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PubMed Mentions: Fields:
-
Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids. J Org Chem. 2005 Aug 19; 70(17):6746-56.
Hanessian S, Yun H, Hou Y, Tintelnot-Blomley M. PMID: 16095294.
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PubMed Mentions:
5 Fields:
Translation:
Cells
-
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem. 2005 Aug 11; 48(16):5175-90.
Hanessian S, Yun H, Hou Y, Yang G, Bayrakdarian M, Therrien E, Moitessier N, Roggo S, Veenstra S, Tintelnot-Blomley M, Rondeau JM, Ostermeier C, Strauss A, Ramage P, Paganetti P, Neumann U, Betschart C. PMID: 16078837.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Synthetic studies in the intramolecular carbocyclization of N-acyloxyiminium ions. Stereoelectronic and steric implications of nucleophilic alkene, alkyne, and allene tethers. J Org Chem. 2005 Jun 24; 70(13):5070-85.
Hanessian S, Tremblay M, Marzi M, Del Valle JR. PMID: 15960507.
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PubMed Mentions:
6 Fields:
-
Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site. Angew Chem Int Ed Engl. 2004 Dec 10; 43(48):6735-8.
François B, Szychowski J, Adhikari SS, Pachamuthu K, Swayze EE, Griffey RH, Migawa MT, Westhof E, Hanessian S. PMID: 15593140.
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PubMed Mentions:
24 Fields:
Translation:
Cells
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Tandem functionalization of nonactivated alkenes and alkynes in intramolecular N-acyloxyiminium ion carbocyclization. Synthesis of 6-substituted hydroindole 2-carboxylic acids. Org Lett. 2004 Dec 09; 6(25):4683-6.
Hanessian S, Tremblay M. PMID: 15575660.
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PubMed Mentions:
4 Fields:
-
Synthesis of 3 10-helix-inducing constrained analogues of L-proline. J Org Chem. 2004 Jul 23; 69(15):4891-9.
Hanessian S, Papeo G, Fettis K, Therrien E, Viet MT. PMID: 15255713.
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PubMed Mentions: Fields:
Translation:
Cells
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Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):11996-2001.
Hanessian S, Mascitti V, Giroux S. PMID: 15210988; PMCID: PMC514423.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin. J Am Chem Soc. 2004 May 19; 126(19):6064-71.
Hanessian S, Tremblay M, Petersen JF. PMID: 15137772.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Sulfonamide-based acyclic and conformationally constrained MMP inhibitors: from computer-assisted design to nanomolar compounds. Curr Top Med Chem. 2004; 4(12):1269-87.
Hanessian S, Moitessier N. PMID: 15320726.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Total synthesis and structural confirmation of malayamycin A: a novel bicyclic C-nucleoside from Streptomyces malaysiensis. Org Lett. 2003 Nov 13; 5(23):4277-80.
Hanessian S, Marcotte S, Machaalani R, Huang G. PMID: 14601979.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate. J Am Chem Soc. 2003 Nov 12; 125(45):13784-92.
Hanessian S, Yang Y, Giroux S, Mascitti V, Ma J, Raeppel F. PMID: 14599218.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Synthesis of functionally diverse and conformationally constrained polycyclic analogues of proline and prolinol. J Org Chem. 2003 Sep 19; 68(19):7204-18.
Hanessian S, Papeo G, Angiolini M, Fettis K, Beretta M, Munro A. PMID: 12968869.
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PubMed Mentions: Fields:
Translation:
Cells
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Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation. J Org Chem. 2003 Sep 19; 68(19):7219-33.
Hanessian S, Sailes H, Munro A, Therrien E. PMID: 12968870.
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PubMed Mentions:
3 Fields:
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Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate. Eur J Neurosci. 2003 Sep; 18(6):1507-17.
Jourquin J, Tremblay E, Décanis N, Charton G, Hanessian S, Chollet AM, Le Diguardher T, Khrestchatisky M, Rivera S. PMID: 14511330.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells. J Med Chem. 2003 Aug 14; 46(17):3600-11.
Hanessian S, Zhan L, Bovey R, Saavedra OM, Juillerat-Jeanneret L. PMID: 12904064.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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The power of visual imagery in drug design. Isopavines as a new class of morphinomimetics and their human opioid receptor binding activity. J Med Chem. 2003 Jan 02; 46(1):34-48.
Hanessian S, Parthasarathy S, Mauduit M, Payza K. PMID: 12502358.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Synthesis of a potent antagonist of E-selectin. J Org Chem. 2002 May 17; 67(10):3346-54.
Hanessian S, Mascitti V, Rogel O. PMID: 12003545.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Design and synthesis of a novel class of constrained tricyclic pyrrolizidinone carboxylic acids as carbapenem mimics. J Org Chem. 2002 May 17; 67(10):3387-97.
Hanessian S, Buckle R, Bayrakdarian M. PMID: 12003550.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Total synthesis of bafilomycin A(1) relying on iterative 1,2-induction in acyclic precursors. J Am Chem Soc. 2001 Oct 24; 123(42):10200-6.
Hanessian S, Ma J, Wang W, Gai Y. PMID: 11603969.
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PubMed Mentions:
4 Fields:
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Highly Diastereoselective Intramolecular [1,2]-Stevens Rearrangements-Asymmetric Syntheses of Functionalized Isopavines as Morphinomimetics. Angew Chem Int Ed Engl. 2001 Oct 15; 40(20):3810-3813.
Hanessian S, Mauduit M. PMID: 29712134.
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PubMed Mentions:
4 Fields:
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A comparative docking study and the design of potentially selective MMP inhibitors. J Comput Aided Mol Des. 2001 Oct; 15(10):873-81.
Hanessian S, Moitessier N, Therrien E. PMID: 11918074.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets. J Med Chem. 2001 Sep 13; 44(19):3066-73.
Hanessian S, Moitessier N, Gauchet C, Viau M. PMID: 11543675.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S(1) pocket using conformationally constrained inhibitors. J Med Chem. 2001 Sep 13; 44(19):3074-82.
Hanessian S, MacKay DB, Moitessier N. PMID: 11543676.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Stereocontrolled glycosyl transfer reactions with unprotected glycosyl donors. Chem Rev. 2000 Dec 13; 100(12):4443-64.
Hanessian S, Lou B. PMID: 11749354.
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PubMed Mentions:
22 Fields:
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Catalytic asymmetric conjugate addition of nitroalkanes to cycloalkenones. Org Lett. 2000 Sep 21; 2(19):2975-8.
Hanessian S, Pham V. PMID: 10986086.
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PubMed Mentions:
3 Fields:
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Asymmetric synthesis of functionalized carbocycles and heterocycles. Chirality. 2000 Jun; 12(5-6):342-5.
Hanessian S, Griffin AM, Cantin LD. PMID: 10824149.
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1 Fields:
Translation:
Cells
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Pyrrolidine as a cogwheel-like scaffold for the deployment of diverse functionality through cycloaddition reactions of metallo-1,3-dipoles in aqueous media. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):427-31.
Hanessian S, Bayrakdarian M. PMID: 10743941.
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PubMed Mentions:
1 Fields:
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Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):439-42.
Hanessian S, Saavedra OM, Xie F, Amboldi N, Battistini C. PMID: 10743943.
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Translation:
HumansCells
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Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases. Bioorg Med Chem Lett. 2000 Mar 06; 10(5):433-7.
Hanessian S, Sgarbi PW. PMID: 10743942.
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PubMed Mentions:
2 Fields:
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Exploring the chiral space within the active site of alpha-thrombin with a constrained mimic of D-Phe-Pro-Arg--design, synthesis, inhibitory activity, and X-ray structure of an enzyme-inhibitor complex. Bioorg Med Chem Lett. 2000 Feb 07; 10(3):243-7.
Hanessian S, Balaux E, Musil D, Olsson LL, Nilsson I. PMID: 10698445.
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1 Fields:
Translation:
Cells
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Synthesis of a phostone glycomimetic of the endothelin converting enzyme inhibitor phosphoramidon. Bioorg Med Chem Lett. 1999 Aug 16; 9(16):2441-6.
Hanessian S, Rogel O. PMID: 10476884.
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1 Fields:
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Cells
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Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. Bioorg Med Chem Lett. 1999 Jun 21; 9(12):1691-6.
Hanessian S, Bouzbouz S, Boudon A, Tucker GC, Peyroulan D. PMID: 10397503.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Asymmetric synthesis of L-azetidine-2-carboxylic acid and 3-substituted congeners--conformationally constrained analogs of phenylalanine, naphthylalanine, and leucine. Bioorg Med Chem Lett. 1999 May 17; 9(10):1437-42.
Hanessian S, Bernstein N, Yang RY, Maguire R. PMID: 10360752.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Synthesis of a versatile peptidomimetic scaffold. Methods Mol Med. 1999; 23:161-74.
Hanessian S, McNaughton-Smith G. PMID: 21380897.
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1 Fields:
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Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin. Bioorg Med Chem Lett. 1998 Oct 06; 8(19):2803-8.
Hanessian S, Huynh HK, Reddy GV, McNaughton-Smith G, Ernst B, Kolb HC, Magnani J, Sweeley C. PMID: 9873626.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity. Bioorg Med Chem Lett. 1998 Aug 18; 8(16):2123-8.
Hanessian S, Reinhold U, Saulnier M, Claridge S. PMID: 9873498.
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AnimalsCells
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Synthesis of 4-amino-4(S)-dihydrospectinomycin. J Antibiot (Tokyo). 1981 Mar; 34(3):350-2.
Hanessian S, Roy R, Therien M, Delorme D. PMID: 6456250.
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Aminoglycoside antibiotics 4'-deoxyneomycin and 4'-deoxyparomamine. J Antibiot (Tokyo). 1980 Jun; 33(6):675-8.
Hanessian S, Vatele JM. PMID: 7419479.
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Studies directed toward the total synthesis of antibiotics: (+)-spectinomycin. Jpn J Antibiot. 1979 Dec; 32 Suppl:S73-90.
Hanessian S, Roy R. PMID: 162067.
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Cells
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Aminoglycoside antibiotics: synthesis of 5''-amino-5''-deoxyneomycin and 5''-amino-5''-deoxyparomomycin. J Antibiot (Tokyo). 1977 Oct; 30(10):893-6.
Hanessian S, Massé R, Capmeau ML. PMID: 591451.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin. J Med Chem. 1976 Dec; 19(12):1424-5.
Arcamone F, Penco S, Redaelli S, Hanessian S. PMID: 1003430.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines. J Med Chem. 1976 May; 19(5):733-4.
Arcamone F, Bargiotii A, Cassinelli G, Redaelli S, Hanessian S, Di Marco A, Casazza AM, Dasdia T, Necco A, Reggiani P, Supino R. PMID: 1271420.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Synthesis of a configurational analog of daunorubicin. Carbohydr Res. 1976 Feb; 46(2):C3-5.
Arcamone F, Bargiotti A, Cassinelli G, Penco S, Hanessian S. PMID: 1260787.
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Cells
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Synthesis of naturally occurring C-nucleosides, their analogs, and functionalized C-glycosyl precursors. Adv Carbohydr Chem Biochem. 1976; 33:111-88.
Hanessian S, Pernet AG. PMID: 793324.
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PubMed Mentions:
3 Fields:
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Aminoglycoside antibiotics: oxidative degradations leading to novel biochemical probes and synthetic intermediates. J Antibiot (Tokyo). 1975 Oct; 28(10):835-7.
Hanessian S, Takamoto T, Masse R. PMID: 1184474.
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PubMed Mentions:
3 Fields:
Translation:
Cells
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Synthetic approaches to kasugamine. Carbohydr Res. 1974 Jul; 35(1):175-85.
Hanessian S, Masse R. PMID: 4854593.
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1 Fields:
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The N6-(dimethylamino)methylene derivative of 9-beta-D-arabinofuranosyladenine as an antiviral agent. J Med Chem. 1973 Mar; 16(3):290-2.
Hanessian S. PMID: 4354694.
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Translation:
HumansAnimalsCells
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Aminoglycoside antibiotics: chemical transformation of paromamine into 3'-epiparomamine. Carbohydr Res. 1973 Jan; 26(1):261-3.
Hanessian S, Butterworth RF, Nakagawa T. PMID: 4696789.
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Synthesis of 6-amino-6-deoxy- , -trehalose: a positional isomer of trehalosamine. J Antibiot (Tokyo). 1972 Nov; 25(11):683-4.
Hanessian S, Lavallee P. PMID: 4647840.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Isolation and characterization of antigenic components of a new heptavalent Pseudomonas vaccine. Nat New Biol. 1971 Feb 17; 229(7):209-10.
Hanessian S, Regan W, Watson D, Haskell TH. PMID: 5281014.
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PubMed Mentions:
32 Fields:
Translation:
Cells
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Mass spectrometry in the detemination of structure of certain natural products containing sugars. Methods Biochem Anal. 1971; 19:105-228.
Hanessian S. PMID: 4935450.
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1 Fields:
Translation:
Cells
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Synthetic penicillins derived from benznorcaradienecarboxylic acids. J Med Chem. 1969 May; 12(3):529-31.
Hanessian S, Schütze G. PMID: 4892245.
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1 Fields:
Translation:
AnimalsCells
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Synthetic penicillins derived from cycloheptatrienecarboxylic acids. J Med Chem. 1969 May; 12(3):527-9.
Hanessian S, Schütze G. PMID: 5788175.
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AnimalsCells
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Synthesis of DL-2-(2,4,6-cycloheptatrien-1-yl)glycine. J Med Chem. 1969 Mar; 12(2):347.
Hanessian S, Schütze G. PMID: 5783621.
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Mass spectrometric studies on aminocyclitol antibiotics. J Am Chem Soc. 1967 Jun 21; 89(13):3364-5.
DeJongh DC, Hribar JD, Hanessian S, Woo PW. PMID: 6042775.
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1 Fields:
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Selective hydrolysis of amide bonds in acetamido deoxy sugars. O-ethyl acetamidium fluoroborates. Tetrahedron Lett. 1967 Apr; 16:1549-52.
Hanessian S. PMID: 6042551.
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2 Fields:
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Further evidence on the structure of cordycepin. Biochim Biophys Acta. 1966 Apr 25; 117(2):480-2.
Hanessian S, DeJongh DC, McCloskey JA. PMID: 5961310.
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3 Fields:
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Deoxy sugars. Adv Carbohydr Chem Biochem. 1966; 21:143-207.
Hanessian S. PMID: 4890108.
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PubMed Mentions:
6 Fields:
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CHARACTERIZATION OF AMINO SUGARS BY MASS SPECTROMETRY. J Am Chem Soc. 1965 Aug 20; 87:3744-51.
DEJONGH DC, HANESSIAN S. PMID: 14338113.
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1 Fields:
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Reductive rearrangement of 5-azido-5-deoxy-pentoses. A new synthesis of sugars containing nitrogen in the ring. Chem Ind. 1965 Jul 17; 29:1296-7.
Hanessian S. PMID: 5841771.
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STRUCTURAL STUDIES ON STAPHYLOCOCCAL POLYSACCHARIDE ANTIGEN. J Biol Chem. 1964 Sep; 239:2758-64.
HANESSIAN S, HASKELL TH. PMID: 14217874.
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PubMed Mentions:
14 Fields:
Translation:
Cells
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THE PURIFICATION AND CHARACTERIZATION OF A NEW ACTIVE IMMUNIZING POLYSACCHARIDE PREPARED FROM STAPHYLOCOCCUS AUREUS. Biochim Biophys Acta. 1964 Mar 02; 83:35-41.
HASKELL TH, HANESSIAN S. PMID: 14152196.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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2-AMINO-2-ISOXY-D-GLUCURONIC ACID, THE MAIN CONSTITUENT OF SPA (STAPHYLOCOCCAL POLYSACCHARIDE ANTIGEN). Nature. 1963 Sep 14; 199:1075-6.
HASKELL TH, HANESSIAN S. PMID: 14066943.
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PubMed Mentions:
3 Fields:
Translation:
Cells