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Klemens J Hertel

Title(s)Professor, Microbiology and Molecular Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2127, 42128, 4
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    Collapse Research 
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    Tracking Gene Expression Dynamics from Transcription to Degradation
    NIH/NIGMS R01GM110244Mar 1, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH/NCI R01CA177651May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    The role of alternative pre-mRNA splicing in breast cancer progression
    NIH/NCI R21CA149548Jun 1, 2010 - May 31, 2013
    Role: Principal Investigator
    Mechanisms of Enhancer Dependent SpliceSite Activation
    NIH/NIGMS R01GM062287Aug 13, 2009 - Jun 30, 2020
    Role: Principal Investigator
    Genomic Analysis of Alternative Splice-Site Selection
    NIH/NIGMS R21GM079413Mar 12, 2007 - Feb 28, 2009
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Publisher Correction: Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. Commun Biol. 2020 Sep 03; 3(1):495. Habowski AN, Flesher JL, Bates JM, Tsai CF, Martin K, Zhao R, Ganesan AK, Edwards RA, Shi T, Wiley HS, Shi Y, Hertel KJ, Waterman ML. PMID: 32884070.
      View in: PubMed   Mentions:
    2. Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. Commun Biol. 2020 Aug 19; 3(1):453. Habowski AN, Flesher JL, Bates JM, Tsai CF, Martin K, Zhao R, Ganesan AK, Edwards RA, Shi T, Wiley HS, Shi Y, Hertel KJ, Waterman ML. PMID: 32814826.
      View in: PubMed   Mentions:
    3. Allosteric Regulation of U1 snRNP by Splicing Regulatory Proteins Controls Spliceosomal Assembly. RNA. 2020 Jun 10. Shenasa H, Movassat M, Forouzmand EJ, Hertel KJ. PMID: 32522889.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process. PLoS One. 2019; 14(10):e0223132. Reynolds DJ, Hertel KJ. PMID: 31581208.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Exon size and sequence conservation improves identification of splice-altering nucleotides. RNA. 2019 12; 25(12):1793-1805. Movassat M, Forouzmand E, Reese F, Hertel KJ. PMID: 31554659.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Combinatorial regulation of alternative splicing. Biochim Biophys Acta Gene Regul Mech. 2019 Nov - Dec; 1862(11-12):194392. Shenasa H, Hertel KJ. PMID: 31276857.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Pancreatic pericytes originate from the embryonic pancreatic mesenchyme. Dev Biol. 2019 05 01; 449(1):14-20. Harari N, Sakhneny L, Khalifa-Malka L, Busch A, Hertel KJ, Hebrok M, Landsman L. PMID: 30771302.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Mol Cell. 2018 01 04; 69(1):62-74.e4. Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi Y. PMID: 29276085.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    9. Preparation of Splicing Competent Nuclear Extract from Mammalian Cells and In Vitro Pre-mRNA Splicing Assay. Methods Mol Biol. 2017; 1648:11-26. Movassat M, Shenasa H, Hertel KJ. PMID: 28766286.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Isolation of Newly Transcribed RNA Using the Metabolic Label 4-Thiouridine. Methods Mol Biol. 2017; 1648:169-176. Garibaldi A, Carranza F, Hertel KJ. PMID: 28766297.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 07 21; 63(2):218-228. Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. PMID: 27397683.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns. RNA Biol. 2016 07 02; 13(7):646-55. Movassat M, Crabb TL, Busch A, Yao C, Reynolds DJ, Shi Y, Hertel KJ. PMID: 27245359.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. The Silent Sway of Splicing by Synonymous Substitutions. J Biol Chem. 2015 Nov 13; 290(46):27700-11. Mueller WF, Larsen LS, Garibaldi A, Hatfield GW, Hertel KJ. PMID: 26424794.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    14. Splicing predictions reliably classify different types of alternative splicing. RNA. 2015 May; 21(5):813-23. Busch A, Hertel KJ. PMID: 25805853.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition. Nucleic Acids Res. 2014 Dec 16; 42(22):13615-32. Hoverter NP, Zeller MD, McQuade MM, Garibaldi A, Busch A, Selwan EM, Hertel KJ, Baldi P, Waterman ML. PMID: 25414359.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Dicer regulates differentiation and viability during mouse pancreatic cancer initiation. PLoS One. 2014; 9(5):e95486. Morris JP, Greer R, Russ HA, von Figura G, Kim GE, Busch A, Lee J, Hertel KJ, Kim S, McManus M, Hebrok M. PMID: 24788257.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014 Mar; 16(3):255-67. von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. PMID: 24561622.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    18. Preparation of splicing competent nuclear extracts. Methods Mol Biol. 2014; 1126:117-21. Webb CH, Hertel KJ. PMID: 24549659.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. In vitro assay of pre-mRNA splicing in mammalian nuclear extract. Methods Mol Biol. 2014; 1126:151-60. Movassat M, Mueller WF, Hertel KJ. PMID: 24549662.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Kinetic analysis of in vitro pre-mRNA splicing in HeLa nuclear extract. Methods Mol Biol. 2014; 1126:161-8. Mueller WF, Hertel KJ. PMID: 24549663.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms. RNA. 2013 Jan; 19(1):96-102. Erkelenz S, Mueller WF, Evans MS, Busch A, Schöneweis K, Hertel KJ, Schaal H. PMID: 23175589.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    22. HEXEvent: a database of Human EXon splicing Events. Nucleic Acids Res. 2013 Jan; 41(Database issue):D118-24. Busch A, Hertel KJ. PMID: 23118488.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    23. Extensive regulation of NAGNAG alternative splicing: new tricks for the spliceosome? Genome Biol. 2012 Feb 22; 13(2):143. Busch A, Hertel KJ. PMID: 22356731.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Evolution of SR protein and hnRNP splicing regulatory factors. Wiley Interdiscip Rev RNA. 2012 Jan-Feb; 3(1):1-12. Busch A, Hertel KJ. PMID: 21898828.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    25. Efficient internal exon recognition depends on near equal contributions from the 3' and 5' splice sites. Nucleic Acids Res. 2011 Nov 01; 39(20):8928-37. Shepard PJ, Choi EA, Busch A, Hertel KJ. PMID: 21795381.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq. RNA. 2011 Apr; 17(4):761-72. Shepard PJ, Choi EA, Lu J, Flanagan LA, Hertel KJ, Shi Y. PMID: 21343387.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    27. SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons. Mol Cell Biol. 2011 Feb; 31(4):793-802. Han J, Ding JH, Byeon CW, Kim JH, Hertel KJ, Jeong S, Fu XD. PMID: 21135118.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    28. G Run-mediated recognition of proteolipid protein and DM20 5' splice sites by U1 small nuclear RNA is regulated by context and proximity to the splice site. J Biol Chem. 2011 Feb 11; 286(6):4059-71. Wang E, Mueller WF, Hertel KJ, Cambi F. PMID: 21127064.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns. RNA. 2010 Sep; 16(9):1786-96. Crabb TL, Lam BJ, Hertel KJ. PMID: 20610656.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Embracing the complexity of pre-mRNA splicing. Cell Res. 2010 Aug; 20(8):866-8. Shepard PJ, Hertel KJ. PMID: 20603640.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    31. Competing upstream 5' splice sites enhance the rate of proximal splicing. Mol Cell Biol. 2010 Apr; 30(8):1878-86. Hicks MJ, Mueller WF, Shepard PJ, Hertel KJ. PMID: 20123971.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    32. Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs. PLoS One. 2009 Dec 08; 4(12):e8204. Geib T, Hertel KJ. PMID: 19997596.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    33. Spliceosomes walk the line: splicing errors and their impact on cellular function. RNA Biol. 2009 Nov-Dec; 6(5):526-30. Hsu SN, Hertel KJ. PMID: 19829058.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. The SR protein family. Genome Biol. 2009; 10(10):242. Shepard PJ, Hertel KJ. PMID: 19857271.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    35. Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):1044-50. Tannukit S, Crabb TL, Hertel KJ, Wen X, Jans DA, Paine ML. PMID: 19857462.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. Dangerous play--splitting the message may leave you empty handed. Nat Struct Mol Biol. 2009 Sep; 16(9):907-8. Klaue Y, Hertel KJ. PMID: 19739289.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. Splice-site pairing is an intrinsically high fidelity process. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1766-71. Fox-Walsh KL, Hertel KJ. PMID: 19179398.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    38. Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex. Mol Cell Biol. 2009 Feb; 29(4):1072-82. Kotlajich MV, Crabb TL, Hertel KJ. PMID: 19064642.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    39. Death by splicing: tumor suppressor RBM5 freezes splice-site pairing. Mol Cell. 2008 Oct 24; 32(2):162-4. Kotlajich MV, Hertel KJ. PMID: 18951082.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Conserved RNA secondary structures promote alternative splicing. RNA. 2008 Aug; 14(8):1463-9. Shepard PJ, Hertel KJ. PMID: 18579871.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    41. Combinatorial control of exon recognition. J Biol Chem. 2008 Jan 18; 283(3):1211-5. Hertel KJ. PMID: 18024426.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    42. The splicing regulators Tra and Tra2 are unusually potent activators of pre-mRNA splicing. Nucleic Acids Res. 2006; 34(22):6612-20. Sciabica KS, Hertel KJ. PMID: 17135210.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    43. Genomic splice-site analysis reveals frequent alternative splicing close to the dominant splice site. RNA. 2006 Dec; 12(12):2047-56. Dou Y, Fox-Walsh KL, Baldi PF, Hertel KJ. PMID: 17053087.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    44. Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns. PLoS Biol. 2006 Jun; 4(6):e147. Hicks MJ, Yang CR, Kotlajich MV, Hertel KJ. PMID: 16640457.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    45. Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays. Methods. 2005 Dec; 37(4):306-13. Hicks MJ, Lam BJ, Hertel KJ. PMID: 16314259.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    46. The architecture of pre-mRNAs affects mechanisms of splice-site pairing. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16176-81. Fox-Walsh KL, Dou Y, Lam BJ, Hung SP, Baldi PF, Hertel KJ. PMID: 16260721.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    47. Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs. Mol Ther. 2005 Dec; 12(6):1013-22. Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ. PMID: 16226920.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    48. Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognition. Nucleic Acids Res. 2005; 33(16):5112-9. Freund M, Hicks MJ, Konermann C, Otte M, Hertel KJ, Schaal H. PMID: 16155183.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    49. Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5002-7. Ibrahim EC, Schaal TD, Hertel KJ, Reed R, Maniatis T. PMID: 15753297.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    50. RS domains contact the pre-mRNA throughout spliceosome assembly. Trends Biochem Sci. 2005 Mar; 30(3):115-8. Hertel KJ, Graveley BR. PMID: 15752982.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    51. Commitment to splice site pairing coincides with A complex formation. Mol Cell. 2004 Aug 13; 15(3):477-83. Lim SR, Hertel KJ. PMID: 15304226.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    52. Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing. J Biol Chem. 2003 Jun 20; 278(25):22740-7. Lam BJ, Bakshi A, Ekinci FY, Webb J, Graveley BR, Hertel KJ. PMID: 12646561.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    53. A general role for splicing enhancers in exon definition. RNA. 2002 Oct; 8(10):1233-41. Lam BJ, Hertel KJ. PMID: 12403462.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    54. Modulation of survival motor neuron pre-mRNA splicing by inhibition of alternative 3' splice site pairing. J Biol Chem. 2001 Nov 30; 276(48):45476-83. Lim SR, Hertel KJ. PMID: 11584013.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    55. The role of U2AF35 and U2AF65 in enhancer-dependent splicing. RNA. 2001 Jun; 7(6):806-18. Graveley BR, Hertel KJ, Maniatis T. PMID: 11421359.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    56. Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2651-5. Hertel KJ, Maniatis T. PMID: 10077565.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    57. SR proteins are 'locators' of the RNA splicing machinery. Curr Biol. 1999 Jan 14; 9(1):R6-7. Graveley BR, Hertel KJ, Maniatis T. PMID: 9889128.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    58. A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. EMBO J. 1998 Nov 16; 17(22):6747-56. Graveley BR, Hertel KJ, Maniatis T. PMID: 9822617.
      View in: PubMed   Mentions: 77     Fields:    Translation:Cells
    59. The function of multisite splicing enhancers. Mol Cell. 1998 Feb; 1(3):449-55. Hertel KJ, Maniatis T. PMID: 9660929.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    60. Common themes in the function of transcription and splicing enhancers. Curr Opin Cell Biol. 1997 Jun; 9(3):350-7. Hertel KJ, Lynch KW, Maniatis T. PMID: 9159075.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    61. Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. RNA. 1996 Oct; 2(10):969-81. Hertel KJ, Lynch KW, Hsiao EC, Liu EH, Maniatis T. PMID: 8849774.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    62. Specificity of hammerhead ribozyme cleavage. EMBO J. 1996 Jul 15; 15(14):3751-7. Hertel KJ, Herschlag D, Uhlenbeck OC. PMID: 8670879.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    63. Inhibition of the hammerhead ribozyme by neomycin. RNA. 1995 Mar; 1(1):95-101. Stage TK, Hertel KJ, Uhlenbeck OC. PMID: 7489494.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    64. A kinetic and thermodynamic framework for the hammerhead ribozyme reaction. Biochemistry. 1994 Mar 22; 33(11):3374-85. Hertel KJ, Herschlag D, Uhlenbeck OC. PMID: 8136375.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    65. Numbering system for the hammerhead. Nucleic Acids Res. 1992 Jun 25; 20(12):3252. Hertel KJ, Pardi A, Uhlenbeck OC, Koizumi M, Ohtsuka E, Uesugi S, Cedergren R, Eckstein F, Gerlach WL, Hodgson R. PMID: 1620624.
      View in: PubMed   Mentions: 90     Fields:    Translation:Cells
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