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Bardwell, Lee

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentDevelopmental & Cell Biology
Address2208 Natural Sciences 1
Zot 2300
CA 92697
Phone(949) 824-6902, 6908
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    Collapse Research 
    Collapse Research Activities and Funding
    MAP kinase cascade signal transmission and specificity
    NIH/NIGMS R01GM060366Feb 1, 2000 - Jan 31, 2010
    Role: Principal Investigator
    PURIFICATION/CHARACTERIZATION OF MAP KINASE FROM YEAST
    NIH/NIGMS F32GM015871Feb 28, 1994
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bardwell AJ, Lagunes L, Zebarjedi R, Bardwell L. The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2. J Biol Chem. 2017 05 26; 292(21):8750-8761. PMID: 28396345.
      View in: PubMed
    2. Bardwell AJ, Bardwell L. Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions. J Biol Chem. 2015 Oct 30; 290(44):26661-74. PMID: 26370088; PMCID: PMC4646321 [Available on 10/30/16].
    3. Mattson-Hoss MK, Niitani Y, Gordon EA, Jun Y, Bardwell L, Tomishige M, Gross SP. CK2 activates kinesin via induction of a conformational change. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7000-5. PMID: 24782540; PMCID: PMC4024924.
    4. Gordon EA, Whisenant TC, Zeller M, Kaake RM, Gordon WM, Krotee P, Patel V, Huang L, Baldi P, Bardwell L. Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. Cell Signal. 2013 Dec; 25(12):2518-29. PMID: 23981301; PMCID: PMC4132694.
    5. Chan C, Liu X, Wang L, Bardwell L, Nie Q, Enciso G. Protein scaffolds can enhance the bistability of multisite phosphorylation systems. PLoS Comput Biol. 2012; 8(6):e1002551. PMID: 22737061; PMCID: PMC3380838.
    6. Xu J, Reddy BJ, Anand P, Shu Z, Cermelli S, Mattson MK, Tripathy SK, Hoss MT, James NS, King SJ, Huang L, Bardwell L, Gross SP. Casein kinase 2 reverses tail-independent inactivation of kinesin-1. Nat Commun. 2012 Mar 27; 3:754. PMID: 22453827; PMCID: PMC3574636.
    7. Chou CS, Bardwell L, Nie Q, Yi TM. Noise filtering tradeoffs in spatial gradient sensing and cell polarization response. BMC Syst Biol. 2011 Dec 13; 5:196. PMID: 22166067; PMCID: PMC3268761.
    8. Bernardo AS, Faial T, Gardner L, Niakan KK, Ortmann D, Senner CE, Callery EM, Trotter MW, Hemberger M, Smith JC, Bardwell L, Moffett A, Pedersen RA. BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell. 2011 Aug 05; 9(2):144-55. PMID: 21816365; PMCID: PMC3567433.
    9. Hetherington AM, Bardwell L. Plant signalling pathways: a comparative evolutionary overview. Curr Biol. 2011 May 10; 21(9):R317-9. PMID: 21549953.
      View in: PubMed
    10. Bardwell L. Synthetic biology: modulating the MAP kinase module. Curr Biol. 2011 Apr 12; 21(7):R249-51. PMID: 21481758.
      View in: PubMed
    11. Whisenant TC, Ho DT, Benz RW, Rogers JS, Kaake RM, Gordon EA, Huang L, Baldi P, Bardwell L. Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol. 2010 Aug 26; 6(8). PMID: 20865152; PMCID: PMC2928751.
    12. Haney S, Bardwell L, Nie Q. Ultrasensitive responses and specificity in cell signaling. BMC Syst Biol. 2010 Aug 25; 4:119. PMID: 20735856; PMCID: PMC2940771.
    13. Liu X, Bardwell L, Nie Q. A combination of multisite phosphorylation and substrate sequestration produces switchlike responses. Biophys J. 2010 Apr 21; 98(8):1396-407. PMID: 20409458; PMCID: PMC2856190.
    14. Compani B, Su T, Chang I, Cheng J, Shah KH, Whisenant T, Dou Y, Bergmann A, Cheong R, Wold B, Bardwell L, Levchenko A, Baldi P, Mjolsness E. A scalable and integrative system for pathway bioinformatics and systems biology. Adv Exp Med Biol. 2010; 680:523-34. PMID: 20865537; PMCID: PMC3021415.
    15. Bardwell AJ, Frankson E, Bardwell L. Selectivity of docking sites in MAPK kinases. J Biol Chem. 2009 May 08; 284(19):13165-73. PMID: 19196711; PMCID: PMC2676048.
    16. Hilioti Z, Sabbagh W, Paliwal S, Bergmann A, Goncalves MD, Bardwell L, Levchenko A. Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol. 2008 Nov 11; 18(21):1700-6. PMID: 18976914; PMCID: PMC2602854.
    17. Bardwell L. Signal transduction: turning a switch into a rheostat. Curr Biol. 2008 Oct 14; 18(19):R910-2. PMID: 18957235; PMCID: PMC3017499.
    18. Bardwell L, Zou X, Nie Q, Komarova NL. Mathematical models of specificity in cell signaling. Biophys J. 2007 May 15; 92(10):3425-41. PMID: 17325015; PMCID: PMC1853162.
    19. Bardwell L. Mechanisms of MAPK signalling specificity. Biochem Soc Trans. 2006 Nov; 34(Pt 5):837-41. PMID: 17052210; PMCID: PMC3017501.
    20. Bardwell L, Shah K. Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates. Methods. 2006 Nov; 40(3):213-23. PMID: 16884917; PMCID: PMC3017500.
    21. Bardwell L. G-protein signaling: a new branch in an old pathway. Curr Biol. 2006 Oct 10; 16(19):R853-5. PMID: 17027484; PMCID: PMC3017505.
    22. Ho DT, Bardwell AJ, Grewal S, Iverson C, Bardwell L. Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. J Biol Chem. 2006 May 12; 281(19):13169-79. PMID: 16533805; PMCID: PMC3017509.
    23. Molina DM, Grewal S, Bardwell L. Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation. J Biol Chem. 2005 Dec 23; 280(51):42051-60. PMID: 16246839; PMCID: PMC3017498.
    24. Komarova NL, Zou X, Nie Q, Bardwell L. A theoretical framework for specificity in cell signaling. Mol Syst Biol. 2005; 1:2005.0023. PMID: 16729058; PMCID: PMC1681467.
    25. Flatauer LJ, Zadeh SF, Bardwell L. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol Cell Biol. 2005 Mar; 25(5):1793-803. PMID: 15713635; PMCID: PMC549360.
    26. Bardwell L. A walk-through of the yeast mating pheromone response pathway. Peptides. 2005 Feb; 26(2):339-50. PMID: 15690603.
      View in: PubMed
    27. Bardwell L. A walk-through of the yeast mating pheromone response pathway. Peptides. 2004 Sep; 25(9):1465-76. PMID: 15374648.
      View in: PubMed
    28. Cullen PJ, Sabbagh W, Graham E, Irick MM, van Olden EK, Neal C, Delrow J, Bardwell L, Sprague GF. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev. 2004 Jul 15; 18(14):1695-708. PMID: 15256499; PMCID: PMC478191.
    29. Bardwell AJ, Abdollahi M, Bardwell L. Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs. Biochem J. 2004 Mar 01; 378(Pt 2):569-77. PMID: 14616089; PMCID: PMC1223970.
    30. Kusari AB, Molina DM, Sabbagh W, Lau CS, Bardwell L. A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1. J Cell Biol. 2004 Jan 19; 164(2):267-77. PMID: 14734536; PMCID: PMC2172336.
    31. Ho DT, Bardwell AJ, Abdollahi M, Bardwell L. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003 Aug 29; 278(35):32662-72. PMID: 12788955; PMCID: PMC3017503.
    32. Bardwell AJ, Abdollahi M, Bardwell L. Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J. 2003 Mar 15; 370(Pt 3):1077-85. PMID: 12529172; PMCID: PMC1223246.
    33. Bardwell AJ, Flatauer LJ, Matsukuma K, Thorner J, Bardwell L. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem. 2001 Mar 30; 276(13):10374-86. PMID: 11134045; PMCID: PMC3021106.