Lee Bardwell

Title(s)Professor and Vice Chair, Developmental & Cell Biology
SchoolSchool of Biological Sciences
Address2208 Natural Sciences 1
Zot 2300
Irvine CA 92697
Phone(949) 824-6902, 6908
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    Collapse Research 
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    MAP kinase cascade signal transmission and specificity
    NIH R01GM060366Feb 1, 2000 - Jan 31, 2010
    Role: Principal Investigator
    NIH F32GM015871Feb 28, 1994
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitogen-activated protein kinase (MAPK) cascades-A yeast perspective. Enzymes. 2023; 54:137-170. Bardwell L, Thorner J. PMID: 37945169.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase. Biochem J. 2023 May 05. Bardwell AJ, Paul M, Yoneda KC, Andrade-Ludeña MD, Nguyen OT, Fruman D, Bardwell L. PMID: 37145016; PMCID: PMC10625650.
      View in: PubMed   Mentions:    Fields:    
    3. ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1. Life Sci Alliance. 2022 11; 5(11). Bardwell AJ, Wu B, Sarin KY, Waterman ML, Atwood SX, Bardwell L. PMID: 35831023; PMCID: PMC9279676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nat Cell Biol. 2022 01; 24(1):74-87. Han H, Nakaoka HJ, Hofmann L, Zhou JJ, Yu C, Zeng L, Nan J, Seo G, Vargas RE, Yang B, Qi R, Bardwell L, Fishman DA, Cho KWY, Huang L, Luo R, Warrior R, Wang W. PMID: 35027733; PMCID: PMC9022944.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Effect of magnitude and variability of energy of activation in multisite ultrasensitive biochemical processes. PLoS Comput Biol. 2020 08; 16(8):e1007966. Lagunes L, Bardwell L, Enciso GA. PMID: 32760072; PMCID: PMC7444825.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Cancer Mutations: Molecular MEKanisms. Curr Biol. 2020 03 09; 30(5):R222-R224. Bardwell L. PMID: 32155425.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Pseudokinases: Flipping the ATP for AMPylation. Curr Biol. 2019 01 07; 29(1):R23-R25. Bardwell L. PMID: 30620911.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila. Dev Biol. 2019 01 01; 445(1):37-53. Syed A, Lukacsovich T, Pomeroy M, Bardwell AJ, Decker GT, Waymire KG, Purcell J, Huang W, Gui J, Padilla EM, Park C, Paul A, Pham TBT, Rodriguez Y, Wei S, Worthge S, Zebarjedi R, Zhang B, Bardwell L, Marsh JL, MacGregor GR. PMID: 30539716; PMCID: PMC6294335.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2. J Biol Chem. 2017 05 26; 292(21):8750-8761. Bardwell AJ, Lagunes L, Zebarjedi R, Bardwell L. PMID: 28396345; PMCID: PMC5448102.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions. J Biol Chem. 2015 Oct 30; 290(44):26661-74. Bardwell AJ, Bardwell L. PMID: 26370088; PMCID: PMC4646321.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. CK2 activates kinesin via induction of a conformational change. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7000-5. Mattson-Hoss MK, Niitani Y, Gordon EA, Jun Y, Bardwell L, Tomishige M, Gross SP. PMID: 24782540; PMCID: PMC4024924.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. Cell Signal. 2013 Dec; 25(12):2518-29. Gordon EA, Whisenant TC, Zeller M, Kaake RM, Gordon WM, Krotee P, Patel V, Huang L, Baldi P, Bardwell L. PMID: 23981301; PMCID: PMC4132694.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Protein scaffolds can enhance the bistability of multisite phosphorylation systems. PLoS Comput Biol. 2012; 8(6):e1002551. Chan C, Liu X, Wang L, Bardwell L, Nie Q, Enciso G. PMID: 22737061; PMCID: PMC3380838.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    14. Casein kinase 2 reverses tail-independent inactivation of kinesin-1. Nat Commun. 2012 Mar 27; 3:754. Xu J, Reddy BJ, Anand P, Shu Z, Cermelli S, Mattson MK, Tripathy SK, Hoss MT, James NS, King SJ, Huang L, Bardwell L, Gross SP. PMID: 22453827; PMCID: PMC3574636.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Noise filtering tradeoffs in spatial gradient sensing and cell polarization response. BMC Syst Biol. 2011 Dec 13; 5:196. Chou CS, Bardwell L, Nie Q, Yi TM. PMID: 22166067; PMCID: PMC3268761.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages. Cell Stem Cell. 2011 Aug 05; 9(2):144-55. Bernardo AS, Faial T, Gardner L, Niakan KK, Ortmann D, Senner CE, Callery EM, Trotter MW, Hemberger M, Smith JC, Bardwell L, Moffett A, Pedersen RA. PMID: 21816365; PMCID: PMC3567433.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    17. Plant signalling pathways: a comparative evolutionary overview. Curr Biol. 2011 May 10; 21(9):R317-9. Hetherington AM, Bardwell L. PMID: 21549953.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Synthetic biology: modulating the MAP kinase module. Curr Biol. 2011 Apr 12; 21(7):R249-51. Bardwell L. PMID: 21481758.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors. PLoS Comput Biol. 2010 Aug 26; 6(8). Whisenant TC, Ho DT, Benz RW, Rogers JS, Kaake RM, Gordon EA, Huang L, Baldi P, Bardwell L. PMID: 20865152; PMCID: PMC2928751.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    20. Ultrasensitive responses and specificity in cell signaling. BMC Syst Biol. 2010 Aug 25; 4:119. Haney S, Bardwell L, Nie Q. PMID: 20735856; PMCID: PMC2940771.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    21. A combination of multisite phosphorylation and substrate sequestration produces switchlike responses. Biophys J. 2010 Apr 21; 98(8):1396-407. Liu X, Bardwell L, Nie Q. PMID: 20409458; PMCID: PMC2856190.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    22. A scalable and integrative system for pathway bioinformatics and systems biology. Adv Exp Med Biol. 2010; 680:523-34. Compani B, Su T, Chang I, Cheng J, Shah KH, Whisenant T, Dou Y, Bergmann A, Cheong R, Wold B, Bardwell L, Levchenko A, Baldi P, Mjolsness E. PMID: 20865537; PMCID: PMC3021415.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    23. Selectivity of docking sites in MAPK kinases. J Biol Chem. 2009 May 08; 284(19):13165-73. Bardwell AJ, Frankson E, Bardwell L. PMID: 19196711; PMCID: PMC2676048.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    24. Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol. 2008 Nov 11; 18(21):1700-6. Hilioti Z, Sabbagh W, Paliwal S, Bergmann A, Goncalves MD, Bardwell L, Levchenko A. PMID: 18976914; PMCID: PMC2602854.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    25. Signal transduction: turning a switch into a rheostat. Curr Biol. 2008 Oct 14; 18(19):R910-2. Bardwell L. PMID: 18957235; PMCID: PMC3017499.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. Mathematical models of specificity in cell signaling. Biophys J. 2007 May 15; 92(10):3425-41. Bardwell L, Zou X, Nie Q, Komarova NL. PMID: 17325015; PMCID: PMC1853162.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    27. Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates. Methods. 2006 Nov; 40(3):213-23. Bardwell L, Shah K. PMID: 16884917; PMCID: PMC3017500.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    28. Mechanisms of MAPK signalling specificity. Biochem Soc Trans. 2006 Nov; 34(Pt 5):837-41. Bardwell L. PMID: 17052210; PMCID: PMC3017501.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    29. G-protein signaling: a new branch in an old pathway. Curr Biol. 2006 Oct 10; 16(19):R853-5. Bardwell L. PMID: 17027484; PMCID: PMC3017505.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    30. Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. J Biol Chem. 2006 May 12; 281(19):13169-13179. Ho DT, Bardwell AJ, Grewal S, Iverson C, Bardwell L. PMID: 16533805; PMCID: PMC3017509.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    31. Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation. J Biol Chem. 2005 Dec 23; 280(51):42051-60. Molina DM, Grewal S, Bardwell L. PMID: 16246839; PMCID: PMC3017498.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    32. A theoretical framework for specificity in cell signaling. Mol Syst Biol. 2005; 1:2005.0023. Komarova NL, Zou X, Nie Q, Bardwell L. PMID: 16729058; PMCID: PMC1681467.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    33. Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo. Cell Signal. 2006 Jan; 18(1):123-34. Grewal S, Molina DM, Bardwell L. PMID: 15979847; PMCID: PMC3017502.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    34. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol Cell Biol. 2005 Mar; 25(5):1793-803. Flatauer LJ, Zadeh SF, Bardwell L. PMID: 15713635; PMCID: PMC549360.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    35. A walk-through of the yeast mating pheromone response pathway. Peptides. 2005 Feb; 26(2):339-50. Bardwell L. PMID: 15690603; PMCID: PMC3017506.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    36. A walk-through of the yeast mating pheromone response pathway. Peptides. 2004 Sep; 25(9):1465-76. Bardwell L. PMID: 15374648.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    37. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev. 2004 Jul 15; 18(14):1695-708. Cullen PJ, Sabbagh W, Graham E, Irick MM, van Olden EK, Neal C, Delrow J, Bardwell L, Sprague GF. PMID: 15256499; PMCID: PMC478191.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    38. Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs. Biochem J. 2004 Mar 01; 378(Pt 2):569-77. Bardwell AJ, Abdollahi M, Bardwell L. PMID: 14616089; PMCID: PMC1223970.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    39. A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1. J Cell Biol. 2004 Jan 19; 164(2):267-77. Kusari AB, Molina DM, Sabbagh W, Lau CS, Bardwell L. PMID: 14734536; PMCID: PMC2172336.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    40. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. J Biol Chem. 2003 Aug 29; 278(35):32662-72. Ho DT, Bardwell AJ, Abdollahi M, Bardwell L. PMID: 12788955; PMCID: PMC3017503.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    41. Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J. 2003 Mar 15; 370(Pt 3):1077-85. Bardwell AJ, Abdollahi M, Bardwell L. PMID: 12529172; PMCID: PMC1223246.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    42. A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem. 2001 Mar 30; 276(13):10374-86. Bardwell AJ, Flatauer LJ, Matsukuma K, Thorner J, Bardwell L. PMID: 11134045; PMCID: PMC3021106.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells