Michael Cahalan

Title(s)Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7776
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    Collapse Research Activities and Funding
    Cellular and Molecular Mechanisms of Regulatory T Cells in EAE
    NIH R01AI121945Jun 20, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Cellular and Molecular Mechanisms of Regulatory T Cells in EAE
    NIH R56AI121945Feb 5, 2016 - Jun 19, 2016
    Role: Principal Investigator
    A Transgenic Mouse Line to Map Cell-Type Specific Calcium Signals In Vivo
    NIH R21AI117555Feb 1, 2015 - Jan 31, 2018
    Role: Principal Investigator
    Immunology Research Training Grant
    NIH T32AI060573Jul 1, 2004 - Jul 31, 2021
    Role: Co-Principal Investigator
    SMALL INSTRUMENTATION GRANT
    NIH S15CA055990Aug 1, 1991 - Jul 31, 1992
    Role: Principal Investigator
    BIOMEDICAL RESEARCH SUPPORT GRANT
    NIH S10RR005912Jun 1, 1990 - Dec 31, 1991
    Role: Principal Investigator
    THE ROLE OF ION CHANNELS IN T LYMPHOCYTE ACTIVATION
    NIH R01AI021808Dec 1, 1984 - Nov 30, 1987
    Role: Principal Investigator
    Functional immuno-imaging of lymphocyte motility and cell interactions in lymph n
    NIH R01GM041514May 1, 1984 - Mar 31, 2015
    Role: Principal Investigator
    MOLECULAR MECHANISMS IN EXCITABLE MEMBRANES
    NIH K04NS000662Jul 1, 1981 - Jun 30, 1986
    Role: Principal Investigator
    Molecular Mechanisms of lon Channels in T Lymphocytes
    NIH R01NS014609Sep 15, 1978 - May 31, 2023
    Role: Principal Investigator
    Molecular Mechanisms of lon Channels in T Lymphocytes
    NIH R56NS014609Sep 15, 1978 - Jul 31, 2019
    Role: Principal Investigator
    Molecular Mechanisms of Ion Channels in T Lymphocytes
    NIH R37NS014609Sep 15, 1978 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Photoswitching alters fluorescence readout of jGCaMP8 Ca2+ indicators tethered to Orai1 channels. Proc Natl Acad Sci U S A. 2023 09 26; 120(39):e2309328120. Dynes JL, Yeromin AV, Cahalan MD. PMID: 37729200; PMCID: PMC10523504.
      View in: PubMed   Mentions:    Fields:    
    2. Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2023 Mar 02; 14(1):1194. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 36864071; PMCID: PMC9981556.
      View in: PubMed   Mentions:    Fields:    
    3. Voltage-gated Ca2+ channel proteins do not function as ion channels in T cells. Sci Signal. 2022 06 14; 15(738):eabq5594. Cahalan MD. PMID: 35700266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses. Cell Rep. 2022 03 29; 38(13):110600. Bolton JL, Short AK, Othy S, Kooiker CL, Shao M, Gunn BG, Beck J, Bai X, Law SM, Savage JC, Lambert JJ, Belelli D, Tremblay MÈ, Cahalan MD, Baram TZ. PMID: 35354026; PMCID: PMC9014810.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    5. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife. 2022 02 22; 11. Jairaman A, McQuade A, Granzotto A, Kang YJ, Chadarevian JP, Gandhi S, Parker I, Smith I, Cho H, Sensi SL, Othy S, Blurton-Jones M, Cahalan MD. PMID: 35191835; PMCID: PMC8906810.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    6. The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model. Alzheimers Dement. 2022 10; 18(10):1765-1778. Claes C, England WE, Danhash EP, Kiani Shabestari S, Jairaman A, Chadarevian JP, Hasselmann J, Tsai AP, Coburn MA, Sanchez J, Lim TE, Hidalgo JLS, Tu C, Cahalan MD, Lamb BT, Landreth GE, Spitale RC, Blurton-Jones M, Davtyan H. PMID: 35142046; PMCID: PMC9360195.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    7. Calcium Imaging in T Lymphocytes: a Protocol for Use with Genetically Encoded or Chemical Ca2+ Indicators. Bio Protoc. 2021 Oct 05; 11(19):e4170. Jairaman A, Cahalan MD. PMID: 34722817; PMCID: PMC8517641.
      View in: PubMed   Mentions: 1  
    8. Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4+ T cell responses. Sci Adv. 2021 07; 7(28). Jairaman A, Othy S, Dynes JL, Yeromin AV, Zavala A, Greenberg ML, Nourse JL, Holt JR, Cahalan SM, Marangoni F, Parker I, Pathak MM, Cahalan MD. PMID: 34233878; PMCID: PMC8262815.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021 05 31; 12(1):3256. Atcha H, Jairaman A, Holt JR, Meli VS, Nagalla RR, Veerasubramanian PK, Brumm KT, Lim HE, Othy S, Cahalan MD, Pathak MM, Liu WF. PMID: 34059671; PMCID: PMC8167181.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    10. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2020 10 23; 11(1):5370. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 33097708; PMCID: PMC7584603.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    11. Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta. J Gen Physiol. 2020 09 07; 152(9). Dynes JL, Yeromin AV, Cahalan MD. PMID: 32589186; PMCID: PMC7478869.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Calcium Dynamics in Astrocytes During Cell Injury. Front Bioeng Biotechnol. 2020; 8:912. Wakida NM, Gomez-Godinez V, Li H, Nguyen J, Kim EK, Dynes JL, Othy S, Lau AL, Ding P, Shi L, Carmona C, Thompson LM, Cahalan MD, Berns MW. PMID: 32984268; PMCID: PMC7481337.
      View in: PubMed   Mentions: 10  
    13. Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):20088-20099. Othy S, Jairaman A, Dynes JL, Dong TX, Tune C, Yeromin AV, Zavala A, Akunwafo C, Chen F, Parker I, Cahalan MD. PMID: 32732436; PMCID: PMC7443932.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant. Neurobiol Dis. 2020 07; 140:104868. McIntyre LL, Greilach SA, Othy S, Sears-Kraxberger I, Wi B, Ayala-Angulo J, Vu E, Pham Q, Silva J, Dang K, Rezk F, Steward O, Cahalan MD, Lane TE, Walsh CM. PMID: 32276110; PMCID: PMC7253332.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(4):557-567. Skupsky J, Sabui S, Hwang M, Nakasaki M, Cahalan MD, Said HM. PMID: 31786364; PMCID: PMC7078531.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. Cxcl17-/- mice develop exacerbated disease in a T cell-dependent autoimmune model. J Leukoc Biol. 2019 05; 105(5):1027-1039. Hernández-Ruiz M, Othy S, Herrera C, Nguyen HT, Arrevillaga-Boni G, Catalan-Dibene J, Cahalan MD, Zlotnik A. PMID: 30860634; PMCID: PMC8279723.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse. Elife. 2017 12 14; 6. Dong TX, Othy S, Jairaman A, Skupsky J, Zavala A, Parker I, Dynes JL, Cahalan MD. PMID: 29239725; PMCID: PMC5747524.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    18. Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility. Elife. 2017 12 14; 6. Dong TX, Othy S, Greenberg ML, Jairaman A, Akunwafo C, Leverrier S, Yu Y, Parker I, Dynes JL, Cahalan MD. PMID: 29239723; PMCID: PMC5747518.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    19. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017 Apr 19; 94(2):278-293.e9. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. PMID: 28426964; PMCID: PMC5482419.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansAnimalsCells
    20. Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):440-5. Dynes JL, Amcheslavsky A, Cahalan MD. PMID: 26712003; PMCID: PMC4720334.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    21. Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5533-42. Perni S, Dynes JL, Yeromin AV, Cahalan MD, Franzini-Armstrong C. PMID: 26351694; PMCID: PMC4603497.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    22. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp. 2015 Feb 22; (96). Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD. PMID: 25742043; PMCID: PMC4354666.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun. 2015 Feb 05; 6:6219. Matheu MP, Othy S, Greenberg ML, Dong TX, Schuijs M, Deswarte K, Hammad H, Lambrecht BN, Parker I, Cahalan MD. PMID: 25653051; PMCID: PMC4347855.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    24. Molecular biophysics of Orai store-operated Ca2+ channels. Biophys J. 2015 Jan 20; 108(2):237-46. Amcheslavsky A, Wood ML, Yeromin AV, Parker I, Freites JA, Tobias DJ, Cahalan MD. PMID: 25606672; PMCID: PMC4302196.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    25. Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Expert Rev Neurother. 2014 Oct; 14(10):1169-79. Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE. PMID: 25245576; PMCID: PMC4232205.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. PMID: 24843159; PMCID: PMC4050611.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    27. State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation. J Gen Physiol. 2014 May; 143(5):621-31. Amcheslavsky A, Safrina O, Cahalan MD. PMID: 24733836; PMCID: PMC4003185.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101. J Gen Physiol. 2013 Oct; 142(4):405-12. Amcheslavsky A, Safrina O, Cahalan MD. PMID: 24081982; PMCID: PMC3787773.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    29. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. PLoS One. 2013; 8(3):e58033. Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD. PMID: 23533579; PMCID: PMC3606384.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    30. Orai1 function is essential for T cell homing to lymph nodes. J Immunol. 2013 Apr 01; 190(7):3197-206. Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD. PMID: 23455504; PMCID: PMC3608704.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    31. A decade of imaging cellular motility and interaction dynamics in the immune system. Science. 2012 Jun 29; 336(6089):1676-81. Germain RN, Robey EA, Cahalan MD. PMID: 22745423; PMCID: PMC3405774.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCells
    32. Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1258-66. Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, Cahalan MD. PMID: 22511718; PMCID: PMC3356607.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation. Proc Natl Acad Sci U S A. 2011 11 22; 108(47):19072-7. Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P. PMID: 22065776; PMCID: PMC3223456.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    34. Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17832-7. Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I. PMID: 21987805; PMCID: PMC3203769.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    35. Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17838-43. Zhang SL, Yeromin AV, Hu J, Amcheslavsky A, Zheng H, Cahalan MD. PMID: 21987804; PMCID: PMC3203763.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    36. Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro. Integr Biol (Camb). 2011 Jul; 3(7):770-8. Khorshidi MA, Vanherberghen B, Kowalewski JM, Garrod KR, Lindström S, Andersson-Svahn H, Brismar H, Cahalan MD, Önfelt B. PMID: 21687858.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    37. Imaging transplant rejection: a new view. Nat Med. 2011 Jun; 17(6):662-3. Cahalan MD. PMID: 21647143.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Immunoimaging: studying immune system dynamics using two-photon microscopy. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.top99. Matheu MP, Cahalan MD, Parker I. PMID: 21285279.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    39. Induction of an immune response for imaging antigen-presenting cell/T-cell interactions. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5566. Matheu MP, Cahalan MD, Parker I. PMID: 21285266.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    40. In vivo lymph node imaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5568. Matheu MP, Cahalan MD, Parker I. PMID: 21285268.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    41. In situ lymph node imaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5567. Matheu MP, Cahalan MD, Parker I. PMID: 21285267.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    42. General approach to adoptive transfer and cell labeling for immunoimaging. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5565. Matheu MP, Cahalan MD, Parker I. PMID: 21285265.
      View in: PubMed   Mentions: 3     Fields:    
    43. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. PMID: 21148796; PMCID: PMC3133617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity. 2010 Nov 24; 33(5):723-35. Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R. PMID: 21093319; PMCID: PMC3125521.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    45. Cell biology. How to STIMulate calcium channels. Science. 2010 Oct 01; 330(6000):43-4. Cahalan MD. PMID: 20929798; PMCID: PMC3133971.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. The immunological synapse: a dynamic platform for local signaling. J Clin Immunol. 2010 May; 30(3):364-72. Krummel MF, Cahalan MD. PMID: 20390326; PMCID: PMC2874029.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    47. Selective and site-specific mobilization of dermal dendritic cells and Langerhans cells by Th1- and Th2-polarizing adjuvants. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8334-9. Sen D, Forrest L, Kepler TB, Parker I, Cahalan MD. PMID: 20404167; PMCID: PMC2889549.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    48. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J Immunol. 2010 Mar 01; 184(5):2329-36. Garrod KR, Liu FC, Forrest LE, Parker I, Kang SM, Cahalan MD. PMID: 20139277; PMCID: PMC3125519.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    49. The functional network of ion channels in T lymphocytes. Immunol Rev. 2009 Sep; 231(1):59-87. Cahalan MD, Chandy KG. PMID: 19754890; PMCID: PMC3133616.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansAnimalsCells
    50. STIMulating store-operated Ca(2+) entry. Nat Cell Biol. 2009 Jun; 11(6):669-77. Cahalan MD. PMID: 19488056; PMCID: PMC2721799.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    51. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009 May 05; 119(17):2313-22. Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX. PMID: 19380626; PMCID: PMC2749566.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    52. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. PMID: 18835197; PMCID: PMC2732399.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    53. Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo. PLoS One. 2008 Sep 29; 3(9):e3290. Sen D, Deerinck TJ, Ellisman MH, Parker I, Cahalan MD. PMID: 18820727; PMCID: PMC2538605.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    54. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature. 2008 Nov 06; 456(7218):116-20. Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD. PMID: 18820677; PMCID: PMC2597643.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    55. Generation of bone marrow derived murine dendritic cells for use in 2-photon imaging. J Vis Exp. 2008 Jul 09; (17). Matheu MP, Sen D, Cahalan MD, Parker I. PMID: 19066518; PMCID: PMC3278326.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    56. Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem. 2008 Jun 20; 283(25):17662-71. Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD. PMID: 18420579; PMCID: PMC2427323.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    57. Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2011-6. Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD. PMID: 18250319; PMCID: PMC2538873.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    58. Murine skin transplantation. J Vis Exp. 2008 Jan 16; (11). Garrod KR, Cahalan MD. PMID: 19066559; PMCID: PMC2582837.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    59. Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol. 2008; 26:585-626. Cahalan MD, Parker I. PMID: 18173372; PMCID: PMC2732400.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimals
    60. Isolation of CD4+ T cells from mouse lymph nodes using Miltenyi MACS purification. J Vis Exp. 2007; (9):409. Matheu MP, Cahalan MD. PMID: 18989449; PMCID: PMC2566326.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    61. Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1109-13. Oak JS, Matheu MP, Parker I, Cahalan MD, Fruman DA. PMID: 17956290; PMCID: PMC2953540.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Dissection and 2-photon imaging of peripheral lymph nodes in mice. J Vis Exp. 2007; (7):265. Matheu MP, Parker I, Cahalan MD. PMID: 18989436; PMCID: PMC2565854.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    63. Western Blotting using the Invitrogen NuPage Novex Bis Tris minigels. J Vis Exp. 2007; (7):264. Penna A, Cahalan M. PMID: 18989435; PMCID: PMC2565856.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    64. Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol. 2007 Aug 15; 179(4):2261-9. Matheu MP, Deane JA, Parker I, Fruman DA, Cahalan MD. PMID: 17675487.
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    65. Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node. J Immunol. 2007 Aug 01; 179(3):1586-94. Wei SH, Safrina O, Yu Y, Garrod KR, Cahalan MD, Parker I. PMID: 17641025.
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    66. Purifying plasmid DNA from bacterial colonies using the QIAGEN Miniprep Kit. J Vis Exp. 2007; (6):247. Zhang S, Cahalan MD. PMID: 18997895; PMCID: PMC2557117.
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    67. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12081-6. Garrod KR, Wei SH, Parker I, Cahalan MD. PMID: 17609379; PMCID: PMC1924574.
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    68. Molecular basis of the CRAC channel. Cell Calcium. 2007 Aug; 42(2):133-44. Cahalan MD, Zhang SL, Yeromin AV, Ohlsen K, Roos J, Stauderman KA. PMID: 17482674; PMCID: PMC2735391.
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    69. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature. 2006 Sep 14; 443(7108):226-9. Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD. PMID: 16921385; PMCID: PMC2756048.
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    70. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug; 2(8):434-41. Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. PMID: 16829954.
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    71. Imaging the choreography of lymphocyte trafficking and the immune response. Curr Opin Immunol. 2006 Aug; 18(4):476-82. Cahalan MD, Parker I. PMID: 16765574; PMCID: PMC2749663.
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    72. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9357-62. Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD. PMID: 16751269; PMCID: PMC1482614.
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    73. The sense of place in the immune system. Nat Immunol. 2006 Apr; 7(4):329-32. Cahalan MD, Gutman GA. PMID: 16550194; PMCID: PMC2752360.
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    74. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol. 2005 Dec; 6(12):1228-35. Wei SH, Rosen H, Matheu MP, Sanna MG, Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. PMID: 16273098.
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    75. Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Semin Immunol. 2005 Dec; 17(6):442-51. Cahalan MD, Parker I. PMID: 16263308; PMCID: PMC2953541.
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    76. Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. J Gen Physiol. 2005 Nov; 126(5):499-514. Kozak JA, Matsushita M, Nairn AC, Cahalan MD. PMID: 16260839; PMCID: PMC2266608.
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    77. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 2005 Oct 06; 437(7060):902-5. Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD. PMID: 16208375; PMCID: PMC1618826.
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    78. In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. J Exp Med. 2005 Jun 06; 201(11):1815-23. Zinselmeyer BH, Dempster J, Gurney AM, Wokosin D, Miller M, Ho H, Millington OR, Smith KM, Rush CM, Parker I, Cahalan M, Brewer JM, Garside P. PMID: 15928201; PMCID: PMC2213276.
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    79. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005 Jun; 3(6):e150. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG. PMID: 15857154; PMCID: PMC1088276.
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    80. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005 May 09; 169(3):435-45. Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA. PMID: 15866891; PMCID: PMC2171946.
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    81. Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J Biol Chem. 2005 May 27; 280(21):20793-803. Matsushita M, Kozak JA, Shimizu Y, McLachlin DT, Yamaguchi H, Wei FY, Tomizawa K, Matsui H, Chait BT, Cahalan MD, Nairn AC. PMID: 15781465.
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    82. STOP! In the name of positive selection. Nat Immunol. 2005 Feb; 6(2):126-8. Cahalan MD. PMID: 15662438.
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    83. Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med. 2004 Oct 04; 200(7):847-56. Miller MJ, Safrina O, Parker I, Cahalan MD. PMID: 15466619; PMCID: PMC2213293.
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    84. K+ channels as targets for specific immunomodulation. Trends Pharmacol Sci. 2004 May; 25(5):280-9. Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. PMID: 15120495; PMCID: PMC2749963.
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    85. A store-operated calcium channel in Drosophila S2 cells. J Gen Physiol. 2004 Feb; 123(2):167-82. Yeromin AV, Roos J, Stauderman KA, Cahalan MD. PMID: 14744989; PMCID: PMC2217434.
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    86. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):998-1003. Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I. PMID: 14722354; PMCID: PMC327133.
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    87. SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. J Biol Chem. 2004 Feb 20; 279(8):6893-904. Kolski-Andreaco A, Tomita H, Shakkottai VG, Gutman GA, Cahalan MD, Gargus JJ, Chandy KG. PMID: 14638680.
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    88. Regulation of membrane trafficking and subcellular organization of endocytic compartments revealed with FM1-43 in resting and activated human T cells. Exp Cell Res. 2003 Nov 15; 291(1):150-66. Fomina AF, Deerinck TJ, Ellisman MH, Cahalan MD. PMID: 14597416; PMCID: PMC2749753.
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    89. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev. 2003 Oct; 195:136-59. Wei SH, Parker I, Miller MJ, Cahalan MD. PMID: 12969316.
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    90. Real-time imaging of lymphocytes in vivo. Curr Opin Immunol. 2003 Aug; 15(4):372-7. Cahalan MD, Parker I, Wei SH, Miller MJ. PMID: 12900266; PMCID: PMC2953535.
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    91. Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. Mol Psychiatry. 2003 May; 8(5):524-35, 460. Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. PMID: 12808432.
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    92. Polyvalent cations as permeant probes of MIC and TRPM7 pores. Biophys J. 2003 Apr; 84(4):2293-305. Kerschbaum HH, Kozak JA, Cahalan MD. PMID: 12668438; PMCID: PMC1302796.
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    93. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2604-9. Miller MJ, Wei SH, Cahalan MD, Parker I. PMID: 12601158; PMCID: PMC151387.
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    94. MIC channels are inhibited by internal divalent cations but not ATP. Biophys J. 2003 Feb; 84(2 Pt 1):922-7. Kozak JA, Cahalan MD. PMID: 12547774; PMCID: PMC1302670.
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    95. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. J Biol Chem. 2003 Mar 14; 278(11):9928-37. Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. PMID: 12511563.
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    96. Distinct properties of CRAC and MIC channels in RBL cells. J Gen Physiol. 2002 Aug; 120(2):221-35. Kozak JA, Kerschbaum HH, Cahalan MD. PMID: 12149283; PMCID: PMC2234455.
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    97. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 2002 Jun 07; 296(5574):1869-73. Miller MJ, Wei SH, Parker I, Cahalan MD. PMID: 12016203.
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    98. The ins and outs of polycystin-2 as a calcium release channel. Nat Cell Biol. 2002 Mar; 4(3):E56-7. Cahalan MD. PMID: 11875447.
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    99. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
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    100. Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13942-7. Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan MD, Chandy KG, Béraud E. PMID: 11717451; PMCID: PMC61146.
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    101. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon. 2001 Sep; 39(9):1269-76. Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. PMID: 11384714.
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    102. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16; 276(46):43145-51. Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. PMID: 11527975.
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    103. Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol. 2001 Jul; 21(4):235-52. Cahalan MD, Wulff H, Chandy KG. PMID: 11506193.
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    104. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. J Biol Chem. 2001 Aug 24; 276(34):32040-5. Wulff H, Gutman GA, Cahalan MD, Chandy KG. PMID: 11425865.
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    105. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13; 276(15):12249-56. Fanger CM, Rauer H, Neben AL, Miller MJ, Rauer H, Wulff H, Rosa JC, Ganellin CR, Chandy KG, Cahalan MD. PMID: 11278890.
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    106. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. J Biol Chem. 2000 Nov 24; 275(47):37137-49. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. PMID: 10961988.
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    107. Single channel properties and regulated expression of Ca(2+) release-activated Ca(2+) (CRAC) channels in human T cells. J Cell Biol. 2000 Sep 18; 150(6):1435-44. Fomina AF, Fanger CM, Kozak JA, Cahalan MD. PMID: 10995447; PMCID: PMC2150694.
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    108. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 07 05; 97(14):8151-6. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. PMID: 10884437; PMCID: PMC16685.
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    109. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol. 2000 May 15; 149(4):793-8. Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. PMID: 10811821; PMCID: PMC2174559.
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    110. Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. Cell Immunol. 2000 Apr 10; 201(1):6-13. Wei X, Si MS, Imagawa DK, Ji P, Tromberg BJ, Cahalan MD. PMID: 10805968.
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    111. Differential Ca2+ influx, KCa channel activity, and Ca2+ clearance distinguish Th1 and Th2 lymphocytes. J Immunol. 2000 Feb 01; 164(3):1153-60. Fanger CM, Neben AL, Cahalan MD. PMID: 10640725.
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    112. Vanadate induces calcium signaling, Ca2+ release-activated Ca2+ channel activation, and gene expression in T lymphocytes and RBL-2H3 mast cells via thiol oxidation. J Immunol. 2000 Jan 15; 164(2):679-87. Ehring GR, Kerschbaum HH, Fanger CM, Eder C, Rauer H, Cahalan MD. PMID: 10623810.
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    113. Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels. J Biol Chem. 2000 Jan 14; 275(2):1201-8. Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG. PMID: 10625664.
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    114. Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J Biol Chem. 1999 Jul 30; 274(31):21885-92. Rauer H, Pennington M, Cahalan M, Chandy KG. PMID: 10419508.
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    115. Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca(2+) signaling. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8471-6. Wei X, Tromberg BJ, Cahalan MD. PMID: 10411899; PMCID: PMC17540.
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    116. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr; 126(8):1707-16. Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG. PMID: 10372812; PMCID: PMC1565958.
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    117. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem. 1999 Feb 26; 274(9):5746-54. Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J. PMID: 10026195.
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    118. Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytes. Science. 1999 Feb 05; 283(5403):836-9. Kerschbaum HH, Cahalan MD. PMID: 9933165.
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    119. The 52nd annual meeting and symposium of the Society of General Physiologists. Local calcium signaling in cell physiology. J Gen Physiol. 1999 Feb; 113(2):153-9. Andersen OS, Cahalan MD. PMID: 9925813; PMCID: PMC2223365.
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    120. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. 1998 Dec 04; 273(49):32697-707. Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. PMID: 9830012.
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    121. A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes. J Exp Med. 1998 Nov 02; 188(9):1593-602. Ehring GR, Kerschbaum HH, Eder C, Neben AL, Fanger CM, Khoury RM, Negulescu PA, Cahalan MD. PMID: 9802971; PMCID: PMC2212508.
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    122. Monovalent permeability, rectification, and ionic block of store-operated calcium channels in Jurkat T lymphocytes. J Gen Physiol. 1998 Apr; 111(4):521-37. Kerschbaum HH, Cahalan MD. PMID: 9524136; PMCID: PMC2217122.
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    123. Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem. 1998 Mar 06; 273(10):5851-7. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. PMID: 9488722.
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    124. Ion channels in the immune system as targets for immunosuppression. Curr Opin Biotechnol. 1997 Dec; 8(6):749-56. Cahalan MD, Chandy KG. PMID: 9425667.
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    125. Dynamics of ATP-induced calcium signaling in single mouse thymocytes. J Cell Biol. 1997 Sep 08; 138(5):987-98. Ross PE, Ehring GR, Cahalan MD. PMID: 9281578; PMCID: PMC2136769.
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    126. Ion channels, Ca2+ signaling, and reporter gene expression in antigen-specific mouse T cells. J Immunol. 1997 Aug 15; 159(4):1628-38. Kerschbaum HH, Negulescu PA, Cahalan MD. PMID: 9257822.
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    127. Ion channel phenotype of melanoma cell lines. J Membr Biol. 1997 Jan 01; 155(1):27-34. Allen DH, Lepple-Wienhues A, Cahalan MD. PMID: 9002422.
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    128. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec; 50(6):1672-9. Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG. PMID: 8967992.
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    129. Conductance and permeation of monovalent cations through depletion-activated Ca2+ channels (ICRAC) in Jurkat T cells. Biophys J. 1996 Aug; 71(2):787-94. Lepple-Wienhues A, Cahalan MD. PMID: 8842217; PMCID: PMC1233535.
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    130. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity. 1996 May; 4(5):421-30. Negulescu PA, Krasieva TB, Khan A, Kerschbaum HH, Cahalan MD. PMID: 8630728.
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    131. Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes. J Gen Physiol. 1995 Sep; 106(3):415-44. Ross PE, Cahalan MD. PMID: 8786341; PMCID: PMC2229265.
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    132. Voltage-gated and Ca(2+)-activated K+ channels in intact human T lymphocytes. Noninvasive measurements of membrane currents, membrane potential, and intracellular calcium. J Gen Physiol. 1995 Jun; 105(6):765-94. Verheugen JA, Vijverberg HP, Oortgiesen M, Cahalan MD. PMID: 7561743; PMCID: PMC2216960.
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    133. Potassium and calcium channels in lymphocytes. Annu Rev Immunol. 1995; 13:623-53. Lewis RS, Cahalan MD. PMID: 7612237.
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    134. Swelling-activated chloride channels in multidrug-sensitive and -resistant cells. J Gen Physiol. 1994 Dec; 104(6):1129-61. Ehring GR, Osipchuk YV, Cahalan MD. PMID: 7699367; PMCID: PMC2229248.
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    135. Intracellular calcium dependence of gene expression in single T lymphocytes. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2873-7. Negulescu PA, Shastri N, Cahalan MD. PMID: 8146203; PMCID: PMC43473.
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    136. Volume-sensitive Cl- channels in lymphocytes and multidrug-resistant cell lines. Jpn J Physiol. 1994; 44 Suppl 2:S25-30. Cahalan MD, Ehring GR, Osipchuk YV, Ross PE. PMID: 7752536.
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    137. Membrane chloride conductance and capacitance in Jurkat T lymphocytes during osmotic swelling. Biophys J. 1994 Jan; 66(1):169-78. Ross PE, Garber SS, Cahalan MD. PMID: 8130336; PMCID: PMC1275677.
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    138. Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology. J Gen Physiol. 1993 Oct; 102(4):601-30. Grissmer S, Nguyen AN, Cahalan MD. PMID: 7505804; PMCID: PMC2229173.
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    139. Chloride channels activated by osmotic stress in T lymphocytes. J Gen Physiol. 1993 Jun; 101(6):801-26. Lewis RS, Ross PE, Cahalan MD. PMID: 7687269; PMCID: PMC2216748.
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    140. Calcium oscillations in human T and natural killer cells depend upon membrane potential and calcium influx. J Immunol. 1993 Apr 01; 150(7):2620-33. Hess SD, Oortgiesen M, Cahalan MD. PMID: 7681076.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    141. The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells. J Biol Chem. 1992 Oct 15; 267(29):20971-9. Grissmer S, Ghanshani S, Dethlefs B, McPherson JD, Wasmuth JJ, Gutman GA, Cahalan MD, Chandy KG. PMID: 1400413.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    142. Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells. Nature. 1992 Sep 17; 359(6392):241-4. Osipchuk Y, Cahalan M. PMID: 1388246.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    143. Ca(2+)-activated K+ channels in human leukemic T cells. J Gen Physiol. 1992 Jan; 99(1):63-84. Grissmer S, Lewis RS, Cahalan MD. PMID: 1371308; PMCID: PMC2216598.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    144. Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9411-5. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG. PMID: 2251283; PMCID: PMC55175.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    145. CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels. J Immunol. 1990 Oct 01; 145(7):2105-9. Grissmer S, Hanson DC, Natoli EJ, Cahalan MD, Chandy KG. PMID: 1975826.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    146. Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells. Eur J Immunol. 1990 Apr; 20(4):747-51. Chandy KG, Cahalan MD, Grissmer S. PMID: 1971790.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    147. Functional roles of ion channels in lymphocytes. Semin Immunol. 1990 Mar; 2(2):107-17. Cahalan MD, Lewis RS. PMID: 1717052.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    148. G protein control of potassium channel activity in a mast cell line. J Gen Physiol. 1990 Feb; 95(2):205-27. McCloskey MA, Cahalan MD. PMID: 2106571; PMCID: PMC2216315.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    149. Ion channels and signal transduction in lymphocytes. Annu Rev Physiol. 1990; 52:415-30. Lewis RS, Cahalan MD. PMID: 1691906.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    150. Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells. Cell Regul. 1989 Nov; 1(1):99-112. Lewis RS, Cahalan MD. PMID: 2519622; PMCID: PMC361429.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    151. Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes. J Gen Physiol. 1989 Jun; 93(6):1061-74. Sands SB, Lewis RS, Cahalan MD. PMID: 2475579; PMCID: PMC2216250.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    152. Divalent ion trapping inside potassium channels of human T lymphocytes. J Gen Physiol. 1989 Apr; 93(4):609-30. Grissmer S, Cahalan MD. PMID: 2786551; PMCID: PMC2216226.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    153. Voltage-sensitive ion channels in human B lymphocytes. Adv Exp Med Biol. 1989; 254:113-22. Sutro JB, Vayuvegula BS, Gupta S, Cahalan MD. PMID: 2816543.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    154. TEA prevents inactivation while blocking open K+ channels in human T lymphocytes. Biophys J. 1989 Jan; 55(1):203-6. Grissmer S, Cahalan M. PMID: 2784693; PMCID: PMC1330456.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    155. Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases? J Immunol. 1988 Aug 15; 141(4):1137-42. Grissmer S, Cahalan MD, Chandy KG. PMID: 2456342.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    156. The plasticity of ion channels: parallels between the nervous and immune systems. Trends Neurosci. 1988 May; 11(5):214-8. Lewis RS, Cahalan MD. PMID: 2471326.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    157. Subset-specific expression of potassium channels in developing murine T lymphocytes. Science. 1988 Feb 12; 239(4841 Pt 1):771-5. Lewis RS, Cahalan MD. PMID: 2448877.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    158. Role of potassium and chloride channels in volume regulation by T lymphocytes. Soc Gen Physiol Ser. 1988; 43:281-301. Cahalan MD, Lewis RS. PMID: 2479106.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    159. Pandinus imperator scorpion venom blocks voltage-gated potassium channels in nerve fibers. J Neurosci. 1987 Oct; 7(10):3300-5. Pappone PA, Cahalan MD. PMID: 2444679; PMCID: PMC6569190.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    160. Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):405-20. Decoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2435845; PMCID: PMC2215901.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    161. Two types of potassium channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):379-404. Decoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2435844; PMCID: PMC2215902.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    162. Ion channels in T lymphocytes. Adv Exp Med Biol. 1987; 213:85-101. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S, Lewis RS, Sutro JB. PMID: 2442978.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    163. Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation. Science. 1986 Sep 12; 233(4769):1197-200. Chandy KG, DeCoursey TE, Fischbach M, Talal N, Cahalan MD, Gupta S. PMID: 2426784.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    164. Voltage-dependent ion channels in T-lymphocytes. J Neuroimmunol. 1985 Nov; 10(1):71-95. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 2414315.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    165. Electroimmunology: the physiologic role of ion channels in the immune system. J Immunol. 1985 Aug; 135(2 Suppl):787s-791s. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2409167.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    166. Demyelination as a test for a mobile Na channel modulator in frog node of Ranvier. Biophys J. 1985 Feb; 47(2 Pt 1):217-23. Pappone PA, Cahalan MD. PMID: 2579686; PMCID: PMC1435148.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    167. A voltage-gated potassium channel in human T lymphocytes. J Physiol. 1985 Jan; 358:197-237. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S. PMID: 2580081; PMCID: PMC1193339.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansCells
    168. Ion channels in lymphocytes. J Clin Immunol. 1985 Jan; 5(1):1-6. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. PMID: 2579969.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    169. Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med. 1984 Aug 01; 160(2):369-85. Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S. PMID: 6088661; PMCID: PMC2187449.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    170. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984 Feb 2-8; 307(5950):465-8. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. PMID: 6320007.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansCells
    171. Chemical Modification of Potassium Channels in Myelinated Nerve Fibers: Treatment With TNBS or High pH Causes Resistance to Block by 4-Aminopyridine. Biophys J. 1984 Jan; 45(1):62-4. Pappone PA, Cahalan MD. PMID: 19431567; PMCID: PMC1435290.
      View in: PubMed   Mentions: 4     Fields:    
    172. Chemical modification of potassium channel gating in frog myelinated nerve by trinitrobenzene sulphonic acid. J Physiol. 1983 Sep; 342:119-43. Cahalan MD, Pappone PA. PMID: 6313907; PMCID: PMC1193951.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    173. Alamethicin channels incorporated into frog node of ranvier: calcium-induced inactivation and membrane surface charges. J Gen Physiol. 1982 Mar; 79(3):411-36. Cahalan MD, Hall J. PMID: 6281358; PMCID: PMC2215761.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    174. Calcium-induced inactivation of alamethicin in asymmetric lipid bilayers. J Gen Physiol. 1982 Mar; 79(3):387-409. Hall JE, Cahalan MD. PMID: 7077290; PMCID: PMC2215758.
      View in: PubMed   Mentions: 5     Fields:    
    175. Chemical modification of sodium channel surface charges in frog skeletal muscle by trinitrobenzene sulphonic acid. J Physiol. 1981 Dec; 321:127-39. Cahalan MD, Pappone PA. PMID: 6279821; PMCID: PMC1249617.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    176. Sodium channel permeation in squid axons. I: Reversal potential experiments. J Physiol. 1980 Oct; 307:217-42. Begenisich TB, Cahalan MD. PMID: 6259334; PMCID: PMC1283042.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    177. Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations. J Physiol. 1980 Oct; 307:243-57. Begenisich TB, Cahalan MD. PMID: 6259335; PMCID: PMC1283043.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    178. Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin. Biophys J. 1979 Jul; 27(1):39-55. Cahalan MD, Almers W. PMID: 233568; PMCID: PMC1328546.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    179. Block of sodium conductance and gating current in squid giant axons poisoned with quaternary strychnine. Biophys J. 1979 Jul; 27(1):57-73. Cahalan MD, Almers W. PMID: 233569; PMCID: PMC1328547.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    180. Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons. Biophys J. 1978 Aug; 23(2):285-311. Cahalan MD. PMID: 687766; PMCID: PMC1473517.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    181. Sodium channel selectivity. Dependence on internal permeant ion concentration. J Gen Physiol. 1976 Aug; 68(2):111-25. Cahalan M, Begenisich T. PMID: 956766; PMCID: PMC2228421.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    182. Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom. J Physiol. 1975 Jan; 244(2):511-34. Cahalan MD. PMID: 1079869; PMCID: PMC1330774.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
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