Alan L Goldin

Title(s)Interim Vice Chancellor, Microbiology and Molecular Genetics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5334
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    Collapse Research 
    Collapse Research Activities and Funding
    A novel target for the treatment of temporal lobe epilepsy
    NIH R01NS090319Jul 1, 2015 - Jun 30, 2020
    Role: Co-Principal Investigator
    Scn8a and Seizure Resistance
    NIH R01NS065187Apr 1, 2009 - Mar 31, 2014
    Role: Co-Principal Investigator
    Sodium Channel Mutations that cause epilepsy
    NIH R01NS048336Mar 1, 2004 - Apr 30, 2015
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH T32GM008620Jul 1, 1999 - Jun 30, 2024
    Role: Principal Investigator
    NIH R01NS026729Dec 1, 1988 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model. Neuropsychopharmacology. 2021 10; 46(11):2011-2020. Wong JC, Grieco SF, Dutt K, Chen L, Thelin JT, Inglis GAS, Parvin S, Garraway SM, Xu X, Goldin AL, Escayg A. PMID: 33658654; PMCID: PMC8429750.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Molecular charge associated with antiarrhythmic actions in a series of amino-2-cyclohexyl ester derivatives. Eur J Pharmacol. 2019 Feb 05; 844:241-252. Pugsley MK, Yong SL, Goldin AL, Hayes ES, Walker MJA. PMID: 30571955.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker. Biomed Pharmacother. 2018 Oct; 106:510-522. Walker MJA, Hayes ES, Saint DA, Adaikan G, Abraham S, Goldin AL, Beatch GN, MacLeod BA, Wall RA, Pugsley MK. PMID: 29990839; PMCID: PMC6492542.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Early-life febrile seizures worsen adult phenotypes in Scn1a mutants. Exp Neurol. 2017 07; 293:159-171. Dutton SBB, Dutt K, Papale LA, Helmers S, Goldin AL, Escayg A. PMID: 28373025; PMCID: PMC5538963.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    5. Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. 2017 Mar 08; 93(5):1165-1179.e6. Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR. PMID: 28238546; PMCID: PMC5393918.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    6. SCN8A encephalopathy: Research progress and prospects. Epilepsia. 2016 07; 57(7):1027-35. Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, Whittemore V, Wilcox K, Wagnon JL, Pearl PL, Vanderver A, Scheffer IE. PMID: 27270488; PMCID: PMC5495462.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    7. An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior. Exp Neurol. 2016 Jan; 275 Pt 1:46-58. Makinson CD, Dutt K, Lin F, Papale LA, Shankar A, Barela AJ, Liu R, Goldin AL, Escayg A. PMID: 26410685; PMCID: PMC4688066.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    8. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. PMID: 25256961; PMCID: PMC4322077.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    9. Complex genetic interactions in a mouse model of absence epilepsy. Epilepsy Curr. 2015 Jan-Feb; 15(1):50-1. Goldin AL, Escayg A. PMID: 25678893; PMCID: PMC4320963.
      View in: PubMed   Mentions:
    10. Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance. Neurobiol Dis. 2014 Aug; 68:16-25. Makinson CD, Tanaka BS, Lamar T, Goldin AL, Escayg A. PMID: 24704313; PMCID: PMC4077284.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    11. Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. Neuroscience. 2014 May 30; 268:297-308. Gao R, Du Y, Wang L, Nomura Y, Satar G, Gordon D, Gurevitz M, Goldin AL, Dong K. PMID: 24662849; PMCID: PMC4482340.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    12. The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol. 2013 Dec; 170(8):1449-58. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M. PMID: 24528237; PMCID: PMC3892286.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    13. Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci. 2013 Oct 09; 33(41):16310-22. Lioudyno MI, Birch AM, Tanaka BS, Sokolov Y, Goldin AL, Chandy KG, Hall JE, Alkire MT. PMID: 24107962; PMCID: PMC3792466.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    14. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82. Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. PMID: 23090990; PMCID: PMC3494885.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    15. Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. J Biol Chem. 2011 May 06; 286(18):15781-8. Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, Gurevitz M, Goldin AL, Dong K. PMID: 21454658; PMCID: PMC3091187.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia. 2010 Sep; 51(9):1650-8. Escayg A, Goldin AL. PMID: 20831750; PMCID: PMC2937162.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimals
    17. Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem. 2010 Mar 26; 285(13):9823-9834. Martin MS, Dutt K, Papale LA, Dubé CM, Dutton SB, de Haan G, Shankar A, Tufik S, Meisler MH, Baram TZ, Goldin AL, Escayg A. PMID: 20100831; PMCID: PMC2843231.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    18. Sodium channel carboxyl-terminal residue regulates fast inactivation. J Biol Chem. 2010 Mar 19; 285(12):9077-89. Nguyen HM, Goldin AL. PMID: 20089854; PMCID: PMC2838328.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Role of the terminal domains in sodium channel localization. Channels (Austin). 2009 May-Jun; 3(3):171-80. Lee A, Goldin AL. PMID: 19535906; PMCID: PMC2785851.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis. 2009 Jul; 35(1):91-102. Tang B, Dutt K, Papale L, Rusconi R, Shankar A, Hunter J, Tufik S, Yu FH, Catterall WA, Mantegazza M, Goldin AL, Escayg A. PMID: 19409490; PMCID: PMC2735447.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    21. Role of the amino and carboxy termini in isoform-specific sodium channel variation. J Physiol. 2008 Aug 15; 586(16):3917-26. Lee A, Goldin AL. PMID: 18565993; PMCID: PMC2538936.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 2008 Jan 31; 408(1-2):133-45. Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL. PMID: 18077107; PMCID: PMC2744407.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    23. Semliki Forest virus vectors with mutations in the nonstructural protein 2 gene permit extended superinfection of neuronal and non-neuronal cells. J Neurovirol. 2007 Aug; 13(4):353-63. Ehrengruber MU, Goldin AL. PMID: 17849319.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability. J Neurosci. 2006 Mar 08; 26(10):2714-23. Barela AJ, Waddy SP, Lickfett JG, Hunter J, Anido A, Helmers SL, Goldin AL, Escayg A. PMID: 16525050; PMCID: PMC6675156.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    25. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev. 2005 Dec; 57(4):397-409. Catterall WA, Goldin AL, Waxman SG. PMID: 16382098.
      View in: PubMed   Mentions: 565     Fields:    Translation:HumansAnimalsCells
    26. A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci. 2004 Nov 03; 24(44):10022-34. Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL, Meisler MH. PMID: 15525788; PMCID: PMC6730248.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    27. Use-dependent potentiation of the Nav1.6 sodium channel. Biophys J. 2004 Dec; 87(6):3862-72. Zhou W, Goldin AL. PMID: 15465873; PMCID: PMC1304897.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    28. A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron. 2004 Apr 08; 42(1):101-12. Zhou W, Chung I, Liu Z, Goldin AL, Dong K. PMID: 15066268; PMCID: PMC3065994.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    29. Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. J Neurophysiol. 2004 May; 91(5):2040-50. Spampanato J, Aradi I, Soltesz I, Goldin AL. PMID: 14702334.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    30. International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels. Pharmacol Rev. 2003 Dec; 55(4):575-8. Catterall WA, Goldin AL, Waxman SG, International Union of Pharmacology. PMID: 14657413.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    31. Mechanisms of sodium channel inactivation. Curr Opin Neurobiol. 2003 Jun; 13(3):284-90. Goldin AL. PMID: 12850212.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimals
    32. Generalized epilepsy with febrile seizures plus type 2 mutation W1204R alters voltage-dependent gating of Na(v)1.1 sodium channels. Neuroscience. 2003; 116(1):37-48. Spampanato J, Escayg A, Meisler MH, Goldin AL. PMID: 12535936.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    33. Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. J Biol Chem. 2003 Mar 07; 278(10):8717-24. Li RA, Ennis IL, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E. PMID: 12471026.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    34. Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J Neurosci. 2002 Jul 01; 22(13):5300-9. Tan J, Liu Z, Nomura Y, Goldin AL, Dong K. PMID: 12097481; PMCID: PMC3062512.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    35. Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. Insect Biochem Mol Biol. 2002 Apr; 32(4):445-54. Tan J, Liu Z, Tsai TD, Valles SM, Goldin AL, Dong K. PMID: 11886779; PMCID: PMC3057061.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    36. Evolution of voltage-gated Na(+) channels. J Exp Biol. 2002 Mar; 205(Pt 5):575-84. Goldin AL. PMID: 11907047.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    37. Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. J Neurosci. 2001 Oct 01; 21(19):7481-90. Spampanato J, Escayg A, Meisler MH, Goldin AL. PMID: 11567038; PMCID: PMC6762922.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    38. A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neuroscience. 2001; 102(2):307-17. Kearney JA, Plummer NW, Smith MR, Kapur J, Cummins TR, Waxman SG, Goldin AL, Meisler MH. PMID: 11166117.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    39. Resurgence of sodium channel research. Annu Rev Physiol. 2001; 63:871-94. Goldin AL. PMID: 11181979.
      View in: PubMed   Mentions: 248     Fields:    Translation:HumansAnimalsCells
    40. Potent and use-dependent block of cardiac sodium channels by U-50,488H, a benzeneacetamide kappa opioid receptor agonist. Exp Clin Cardiol. 2001; 6(2):61-71. Pugsley MK, Yu EJ, Goldin AL. PMID: 20428265; PMCID: PMC2859007.
      View in: PubMed   Mentions: 1  
    41. Nomenclature of voltage-gated sodium channels. Neuron. 2000 Nov; 28(2):365-8. Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, Hunter JC, Kallen RG, Mandel G, Meisler MH, Netter YB, Noda M, Tamkun MM, Waxman SG, Wood JN, Catterall WA. PMID: 11144347.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimals
    42. Potentiation of rat brain sodium channel currents by PKA in Xenopus oocytes involves the I-II linker. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C638-45. Smith RD, Goldin AL. PMID: 10751312.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    43. U-50,488H, a kappa opioid receptor agonist, is a more potent blocker of cardiac sodium channels than lidocaine. Proc West Pharmacol Soc. 2000; 43:47-50. Pugsley MK, Yu EJ, Goldin AL. PMID: 11056955.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    44. A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel. Neuroreport. 1999 Sep 29; 10(14):3027-31. Smith MR, Goldin AL. PMID: 10549817.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. Molecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921. Br J Pharmacol. 1999 May; 127(1):9-18. Pugsley MK, Goldin AL. PMID: 10369450; PMCID: PMC1565975.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    46. Diversity of mammalian voltage-gated sodium channels. Ann N Y Acad Sci. 1999 Apr 30; 868:38-50. Goldin AL. PMID: 10414280.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    47. Blockade of neuronal sodium channels by the antiepileptic drugs phenytoin, carbamazepine and sodium valproate. Proc West Pharmacol Soc. 1999; 42:105-8. Pugsley MK, Yu EJ, Mclean TH, Goldin AL. PMID: 10697707.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    48. Functional analysis of the mouse Scn8a sodium channel. J Neurosci. 1998 Aug 15; 18(16):6093-102. Smith MR, Smith RD, Plummer NW, Meisler MH, Goldin AL. PMID: 9698304; PMCID: PMC6793187.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    49. Functional analysis of the rat I sodium channel in xenopus oocytes. J Neurosci. 1998 Feb 01; 18(3):811-20. Smith RD, Goldin AL. PMID: 9437003; PMCID: PMC6792772.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    50. Effects of bisaramil, a novel class I antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channels. Eur J Pharmacol. 1998 Jan 19; 342(1):93-104. Pugsley MK, Goldin AL. PMID: 9544797.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    51. High-level expression and detection of ion channels in Xenopus oocytes. Methods Enzymol. 1998; 293:529-56. Shih TM, Smith RD, Toro L, Goldin AL. PMID: 9711627.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    52. Time- and voltage-dependent block of sodium channels expressed in Xenopus oocytes by RSD 921, a novel class I antiarrhythmic drug. Proc West Pharmacol Soc. 1998; 41:75-6. Pugsley MK, Goldin AL. PMID: 9836249.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    53. Interaction between the sodium channel inactivation linker and domain III S4-S5. Biophys J. 1997 Oct; 73(4):1885-95. Smith MR, Goldin AL. PMID: 9336184; PMCID: PMC1181089.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    54. Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit. J Neurosci. 1997 Oct 01; 17(19):7330-8. Cantrell AR, Smith RD, Goldin AL, Scheuer T, Catterall WA. PMID: 9295379; PMCID: PMC6573464.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    55. Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains. J Gen Physiol. 1997 Oct; 110(4):391-401. Kontis KJ, Rounaghi A, Goldin AL. PMID: 9379171; PMCID: PMC2229375.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    56. Sodium channel inactivation is altered by substitution of voltage sensor positive charges. J Gen Physiol. 1997 Oct; 110(4):403-13. Kontis KJ, Goldin AL. PMID: 9379172; PMCID: PMC2229380.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    57. Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. J Neurosci. 1997 Aug 15; 17(16):6086-93. Smith RD, Goldin AL. PMID: 9236220; PMCID: PMC6568332.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    58. Topology of the Shaker potassium channel probed with hydrophilic epitope insertions. J Cell Biol. 1997 Mar 10; 136(5):1037-45. Shih TM, Goldin AL. PMID: 9060468; PMCID: PMC2132486.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    59. Naloxone blockade of sodium currents expressed in Xenopus oocytes. Proc West Pharmacol Soc. 1997; 40:65-7. Pugsley MK, Goldin AL. PMID: 9436215.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    60. A missense mutation in the sodium channel Scn8a is responsible for cerebellar ataxia in the mouse mutant jolting. J Neurosci. 1996 Oct 01; 16(19):5993-9. Kohrman DC, Smith MR, Goldin AL, Harris J, Meisler MH. PMID: 8815882; PMCID: PMC6579185.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    61. Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes. J Neurosci. 1996 Mar 15; 16(6):1965-74. Smith RD, Goldin AL. PMID: 8604040; PMCID: PMC6578500.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    62. The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. J Biol Chem. 1994 Jul 01; 269(26):17649-55. Patton DE, Isom LL, Catterall WA, Goldin AL. PMID: 8021275.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    63. Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches. Pflugers Arch. 1994 Jul; 427(5-6):406-13. Fleig A, Fitch JM, Goldin AL, Rayner MD, Starkus JG, Ruben PC. PMID: 7971139.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    64. A peptide segment critical for sodium channel inactivation functions as an inactivation gate in a potassium channel. Neuron. 1993 Nov; 11(5):967-74. Patton DE, West JW, Catterall WA, Goldin AL. PMID: 8240817.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    65. Accessory subunits and sodium channel inactivation. Curr Opin Neurobiol. 1993 Jun; 3(3):272-7. Goldin AL. PMID: 8396472.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    66. Site-directed mutagenesis of the putative pore region of the rat IIA sodium channel. Mol Pharmacol. 1993 Apr; 43(4):635-44. Kontis KJ, Goldin AL. PMID: 8386312.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    67. Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10905-9. Patton DE, West JW, Catterall WA, Goldin AL. PMID: 1332059; PMCID: PMC50451.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    68. A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10910-4. West JW, Patton DE, Scheuer T, Wang Y, Goldin AL, Catterall WA. PMID: 1332060; PMCID: PMC50452.
      View in: PubMed   Mentions: 320     Fields:    Translation:AnimalsCells
    69. Protein kinase A phosphorylation enhances sodium channel currents in Xenopus oocytes. Am J Physiol. 1992 Sep; 263(3 Pt 1):C660-6. Smith RD, Goldin AL. PMID: 1329522.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    70. Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science. 1992 May 08; 256(5058):839-42. Isom LL, De Jongh KS, Patton DE, Reber BF, Offord J, Charbonneau H, Walsh K, Goldin AL, Catterall WA. PMID: 1375395.
      View in: PubMed   Mentions: 250     Fields:    Translation:AnimalsCells
    71. Preparation of RNA for injection into Xenopus oocytes. Methods Enzymol. 1992; 207:279-97. Goldin AL, Sumikawa K. PMID: 1382184.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    72. Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol. 1992; 207:266-79. Goldin AL. PMID: 1528120.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    73. A voltage-dependent gating transition induces use-dependent block by tetrodotoxin of rat IIA sodium channels expressed in Xenopus oocytes. Neuron. 1991 Oct; 7(4):637-47. Patton DE, Goldin AL. PMID: 1657057.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    74. Expression of ion channels by injection of mRNA into Xenopus oocytes. Methods Cell Biol. 1991; 36:487-509. Goldin AL. PMID: 1725803.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    75. Expression and chromosomal localization of a lymphocyte K+ channel gene. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9411-5. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG. PMID: 2251283; PMCID: PMC55175.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    76. Inactivation of cloned Na channels expressed in Xenopus oocytes. J Gen Physiol. 1990 Oct; 96(4):689-706. Krafte DS, Goldin AL, Auld VJ, Dunn RJ, Davidson N, Lester HA. PMID: 1701828; PMCID: PMC2229013.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    77. A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):323-7. Auld VJ, Goldin AL, Krafte DS, Catterall WA, Lester HA, Davidson N, Dunn RJ. PMID: 1688658; PMCID: PMC53255.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    78. Developmental regulation of sodium channel expression in the rat forebrain. J Biol Chem. 1989 Jun 25; 264(18):10660-6. Scheinman RI, Auld VJ, Goldin AL, Davidson N, Dunn RJ, Catterall WA. PMID: 2543677.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    79. A rat brain Na+ channel alpha subunit with novel gating properties. Neuron. 1988 Aug; 1(6):449-61. Auld VJ, Goldin AL, Krafte DS, Marshall J, Dunn JM, Catterall WA, Lester HA, Davidson N, Dunn RJ. PMID: 2856097.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    80. Tissue-specific expression of the RI and RII sodium channel subtypes. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8682-6. Gordon D, Merrick D, Auld V, Dunn R, Goldin AL, Davidson N, Catterall WA. PMID: 2446328; PMCID: PMC299610.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    81. Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7503-7. Goldin AL, Snutch T, Lübbert H, Dowsett A, Marshall J, Auld V, Downey W, Fritz LC, Lester HA, Dunn R, et al. PMID: 2429308; PMCID: PMC386747.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    82. Stable induction of a 51K cellular protein in neuronal cells surviving herpes simplex virus type 1 infection. Virology. 1985 Apr 30; 142(2):398-405. Goldin AL, Sandri-Goldin RM, Glorioso JC, Levine M. PMID: 2997992.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    83. Transcriptional and genetic analyses of the herpes simplex virus type 1 genome: coordinates 0.29 to 0.45. J Virol. 1984 Mar; 49(3):947-59. Holland LE, Sandri-Goldin RM, Goldin AL, Glorioso JC, Levine M. PMID: 6199514; PMCID: PMC255557.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
    84. High-efficiency transfer of DNA into eukaryotic cells by protoplast fusion. Methods Enzymol. 1983; 101:402-11. Sandri-Goldin RM, Goldin AL, Levine M, Glorioso J. PMID: 6350818.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    85. High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion. Mol Cell Biol. 1981 Aug; 1(8):743-52. Sandri-Goldin RM, Goldin AL, Levine M, Glorioso JC. PMID: 9279387; PMCID: PMC369354.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    86. Persistence of herpes simplex virus genes in cells of neuronal origin. J Virol. 1980 Jul; 35(1):203-10. Levine M, Goldin AL, Glorioso JC. PMID: 6251268; PMCID: PMC288796.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    87. Influence of immune modulators on the oncogenic process: an introduction. Ann N Y Acad Sci. 1976; 276:493-5. Goldin A. PMID: 1071973.
      View in: PubMed   Mentions:    Fields:    
    88. Combination chemotherapy with folate antagonists. Ann N Y Acad Sci. 1971 Nov 30; 186:423-37. Goldin A. PMID: 4944292.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    89. Factors influencing antitumor synergism; relation to screening methodology. Ann N Y Acad Sci. 1958 Dec 05; 76(3):932-8. GOLDIN A, HUMPHREYS SR, VENDITTI JM, MANTEL N. PMID: 13627919.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    90. Studies on the toxicity and antileukemic action of 6-mercaptopurine in mice. Ann N Y Acad Sci. 1954 Dec 06; 60(2):251-66. GOLDIN A, VENDITTI JM, HUMPHREYS SR, DENNIS D, MANTEL N, GREENHOUSE SW. PMID: 14350531.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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