Goldin, Alan L

TitleInterim Vice Chancellor
InstitutionUniversity of California, Irvine
DepartmentMicrobiology and Molecular Biology & Biochemistryar Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-5334, 8508
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    Collapse Research 
    Collapse Research Activities and Funding
    A novel target for the treatment of temporal lobe epilepsy
    NIH/NINDS R01NS090319Jul 1, 2015 - Jun 30, 2019
    Role: Co-Principal Investigator
    Scn8a and Seizure Resistance
    NIH/NINDS R01NS065187Apr 1, 2009 - Mar 31, 2014
    Role: Co-Principal Investigator
    Sodium Channel Mutations that cause epilepsy
    NIH/NINDS R01NS048336Mar 1, 2004 - Apr 30, 2014
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM008620Jul 1, 1999 - Jun 30, 2019
    Role: Principal Investigator
    NIH/NINDS R01NS026729Dec 1, 1988 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dutton SBB, Dutt K, Papale LA, Helmers S, Goldin AL, Escayg A. Early-life febrile seizures worsen adult phenotypes in Scn1a mutants. Exp Neurol. 2017 07; 293:159-171. PMID: 28373025.
      View in: PubMed
    2. Makinson CD, Tanaka BS, Sorokin JM, Wong JC, Christian CA, Goldin AL, Escayg A, Huguenard JR. Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. 2017 Mar 08; 93(5):1165-1179.e6. PMID: 28238546.
      View in: PubMed
    3. Meisler MH, Helman G, Hammer MF, Fureman BE, Gaillard WD, Goldin AL, Hirose S, Ishii A, Kroner BL, Lossin C, Mefford HC, Parent JM, Patel M, Schreiber J, Stewart R, Whittemore V, Wilcox K, Wagnon JL, Pearl PL, Vanderver A, Scheffer IE. SCN8A encephalopathy: Research progress and prospects. Epilepsia. 2016 07; 57(7):1027-35. PMID: 27270488.
      View in: PubMed
    4. Makinson CD, Dutt K, Lin F, Papale LA, Shankar A, Barela AJ, Liu R, Goldin AL, Escayg A. An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior. Exp Neurol. 2016 Jan; 275 Pt 1:46-58. PMID: 26410685; PMCID: PMC4688066 [Available on 01/01/17].
    5. Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics. 2015 Jan; 12(1):234-49. PMID: 25256961; PMCID: PMC4322077.
    6. Goldin AL, Escayg A. Complex genetic interactions in a mouse model of absence epilepsy. Epilepsy Curr. 2015 Jan-Feb; 15(1):50-1. PMID: 25678893; PMCID: PMC4320963.
    7. Makinson CD, Tanaka BS, Lamar T, Goldin AL, Escayg A. Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance. Neurobiol Dis. 2014 Aug; 68:16-25. PMID: 24704313; PMCID: PMC4077284.
    8. Lioudyno MI, Birch AM, Tanaka BS, Sokolov Y, Goldin AL, Chandy KG, Hall JE, Alkire MT. Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics. J Neurosci. 2013 Oct 09; 33(41):16310-22. PMID: 24107962; PMCID: PMC3792466.
    9. Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. Modulation of voltage-gated K+ channels by the sodium channel ß1 subunit. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18577-82. PMID: 23090990; PMCID: PMC3494885.
    10. Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, Gurevitz M, Goldin AL, Dong K. Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. J Biol Chem. 2011 May 06; 286(18):15781-8. PMID: 21454658; PMCID: PMC3091187.
    11. Escayg A, Goldin AL. Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia. 2010 Sep; 51(9):1650-8. PMID: 20831750; PMCID: PMC2937162.
    12. Martin MS, Dutt K, Papale LA, Dubé CM, Dutton SB, de Haan G, Shankar A, Tufik S, Meisler MH, Baram TZ, Goldin AL, Escayg A. Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem. 2010 Mar 26; 285(13):9823-34. PMID: 20100831; PMCID: PMC2843231.
    13. Nguyen HM, Goldin AL. Sodium channel carboxyl-terminal residue regulates fast inactivation. J Biol Chem. 2010 Mar 19; 285(12):9077-89. PMID: 20089854; PMCID: PMC2838328.
    14. Lee A, Goldin AL. Role of the terminal domains in sodium channel localization. Channels (Austin). 2009 May-Jun; 3(3):171-80. PMID: 19535906; PMCID: PMC2785851.
    15. Tang B, Dutt K, Papale L, Rusconi R, Shankar A, Hunter J, Tufik S, Yu FH, Catterall WA, Mantegazza M, Goldin AL, Escayg A. A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis. 2009 Jul; 35(1):91-102. PMID: 19409490; PMCID: PMC2735447.
    16. Lee A, Goldin AL. Role of the amino and carboxy termini in isoform-specific sodium channel variation. J Physiol. 2008 Aug 15; 586(16):3917-26. PMID: 18565993; PMCID: PMC2538936.
    17. Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL. Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 2008 Jan 31; 408(1-2):133-45. PMID: 18077107; PMCID: PMC2744407.
    18. Ehrengruber MU, Goldin AL. Semliki Forest virus vectors with mutations in the nonstructural protein 2 gene permit extended superinfection of neuronal and non-neuronal cells. J Neurovirol. 2007 Aug; 13(4):353-63. PMID: 17849319.
      View in: PubMed
    19. Barela AJ, Waddy SP, Lickfett JG, Hunter J, Anido A, Helmers SL, Goldin AL, Escayg A. An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability. J Neurosci. 2006 Mar 08; 26(10):2714-23. PMID: 16525050.
      View in: PubMed
    20. Catterall WA, Goldin AL, Waxman SG. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev. 2005 Dec; 57(4):397-409. PMID: 16382098.
      View in: PubMed
    21. Zhou W, Chung I, Liu Z, Goldin AL, Dong K. A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron. 2004 Apr 08; 42(1):101-12. PMID: 15066268; PMCID: PMC3065994.
    22. Spampanato J, Aradi I, Soltesz I, Goldin AL. Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. J Neurophysiol. 2004 May; 91(5):2040-50. PMID: 14702334.
      View in: PubMed
    23. Catterall WA, Goldin AL, Waxman SG. International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels. Pharmacol Rev. 2003 Dec; 55(4):575-8. PMID: 14657413.
      View in: PubMed
    24. Goldin AL. Mechanisms of sodium channel inactivation. Curr Opin Neurobiol. 2003 Jun; 13(3):284-90. PMID: 12850212.
      View in: PubMed
    25. Li RA, Ennis IL, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E. Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. J Biol Chem. 2003 Mar 07; 278(10):8717-24. PMID: 12471026.
      View in: PubMed
    26. Tan J, Liu Z, Nomura Y, Goldin AL, Dong K. Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J Neurosci. 2002 Jul 01; 22(13):5300-9. PMID: 12097481; PMCID: PMC3062512.
    27. Hayes ES, Pugsley MK, Goldin AL, Walker MJ. Sodium channel blocking and antiarrhythmic actions of the novel arylpiperazine rsd992. Pharmacol Res. 2002 Jul; 46(1):19-27. PMID: 12208117.
      View in: PubMed
    28. Goldin AL. Evolution of voltage-gated Na(+) channels. J Exp Biol. 2002 Mar; 205(Pt 5):575-84. PMID: 11907047.
      View in: PubMed
    29. Goldin AL. Resurgence of sodium channel research. Annu Rev Physiol. 2001; 63:871-94. PMID: 11181979.
      View in: PubMed
    30. Goldin AL. Diversity of mammalian voltage-gated sodium channels. Ann N Y Acad Sci. 1999 Apr 30; 868:38-50. PMID: 10414280.
      View in: PubMed