Andre J Ouellette

Title(s)Professor Emeritus, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    Host defense-stimulating macrocyclic peptides for treatment of MDR bacterial infections
    NIH R01AI125141May 1, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Innate enteric immunity during induced Paneth cell deficiency
    NIH R21AI105057Aug 15, 2013 - Jul 31, 2016
    Role: Principal Investigator
    STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY
    NIH R01AI059346Jul 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    2005 Antimicrobial Peptides Gordon Conference
    NIH R13AI065005Feb 1, 2005 - Jan 31, 2006
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH R01DK044632May 1, 1993 - Apr 30, 2012
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH R55DK044632Sep 30, 1992 - Apr 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota. Sci Rep. 2023 03 09; 13(1):3953. Nakamura S, Nakamura K, Yokoi Y, Shimizu Y, Ohira S, Hagiwara M, Song Z, Gan L, Aizawa T, Hashimoto D, Teshima T, Ouellette AJ, Ayabe T. PMID: 36894646; PMCID: PMC9998432.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic Pseudomonas aeruginosa Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis. Antibiotics (Basel). 2021 Aug 26; 10(9). Dughbaj MA, Jayne JG, Park AYJ, Bensman TJ, Algorri M, Ouellette AJ, Selsted ME, Beringer PM. PMID: 34572625; PMCID: PMC8466744.
      View in: PubMed   Mentions: 2  
    3. p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 2021 Mar 14; 13(6). Lai KKY, Hu X, Chosa K, Nguyen C, Lin DP, Lai KK, Kato N, Higuchi Y, Highlander SK, Melendez E, Eriguchi Y, Fueger PT, Ouellette AJ, Chimge NO, Ono M, Kahn M. PMID: 33799418; PMCID: PMC7999107.
      View in: PubMed   Mentions: 5  
    4. Rapamycin rejuvenates oral health in aging mice. Elife. 2020 04 28; 9. An JY, Kerns KA, Ouellette A, Robinson L, Morris HD, Kaczorowski C, Park SI, Mekvanich T, Kang A, McLean JS, Cox TC, Kaeberlein M. PMID: 32342860; PMCID: PMC7220376.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    5. Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. Patil AA, Ouellette AJ, Lu W, Zhang G. PMID: 23380721; PMCID: PMC3623328.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012 Nov 13; 1:e00003. Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP. PMID: 23150794; PMCID: PMC3491588.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    7. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 06; 50(48):10508-19. Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA. PMID: 22040603; PMCID: PMC3236816.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008 Nov 25; 47(47):12626-34. Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E. PMID: 18973303; PMCID: PMC2645939.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    9. Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. J Pept Sci. 2008 Apr; 14(4):503-9. Miszta A, Machán R, Benda A, Ouellette AJ, Hermens WT, Hof M. PMID: 17994618.
      View in: PubMed   Mentions: 8     Fields:    
    10. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. PMID: 18160518; PMCID: PMC2258523.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    11. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53. Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. PMID: 17617617.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    12. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78. Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. PMID: 16857681.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    13. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ. PMID: 16822871.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    14. Paneth cell alpha-defensin synthesis and function. Curr Top Microbiol Immunol. 2006; 306:1-25. Ouellette AJ. PMID: 16909916.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    15. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. Ouellette AJ. PMID: 15931529.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    16. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. Selsted ME, Ouellette AJ. PMID: 15908936.
      View in: PubMed   Mentions: 446     Fields:    Translation:HumansAnimalsCells
    17. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99. Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC. PMID: 15819632.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    18. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20. Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. PMID: 15784576; PMCID: PMC1087394.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    19. Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66. Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. PMID: 15595831.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE. PMID: 15479803; PMCID: PMC523300.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    21. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96. Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ. PMID: 15297466.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    22. Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. Ouellette AJ. PMID: 15123078.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    23. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. PMID: 14977952; PMCID: PMC356057.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7. Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. PMID: 14990585.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    25. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM. PMID: 14715526.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    26. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ. PMID: 14702345.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    27. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ. PMID: 15019212.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    28. Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette AJ, Jelinek R. PMID: 12574157.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    29. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 07; 278(10):7910-9. Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette AJ. PMID: 12482850.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    30. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. PMID: 11733520.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    31. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Paneth cell defensins and innate immunity of the small bowel. Inflamm Bowel Dis. 2001 Feb; 7(1):43-50. Ouellette AJ, Bevins CL. PMID: 11233660.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    33. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. Infect Immun. 1999 Dec; 67(12):6643-51. Ouellette AJ, Darmoul D, Tran D, Huttner KM, Yuan J, Selsted ME. PMID: 10569786; PMCID: PMC97078.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    34. IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol. 1999 08; 277(2):G257-61. Ouellette AJ. PMID: 10444437.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    35. Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology. 1997 Nov; 113(5):1779-84. Ouellette AJ. PMID: 9352884.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
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