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Zlotnik, Albert

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentPhysiology and Biophysics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-0876
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    Collapse Research 
    Collapse Research Activities and Funding
    Role of meteorin-like in the immune system
    NIH/NIAID R21AI128465Dec 13, 2016 - Nov 30, 2018
    Role: Principal Investigator
    The new chemokine CCL28 and its role during Salmonella infection
    NIH/NIAID R21AI121928Jan 1, 2016 - Dec 31, 2017
    Role: Co-Principal Investigator
    Functional characterization of IL-40, a novel cytokine
    NIH/NIAID R21AI117556Feb 1, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Characterization of CCL28,CXCL14, and CXCL17, three mucosal chemokines
    NIH/NIAID R01AI093548Dec 5, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Characterization of IL36, a novel cytokine
    NIH/NIAID R21AI096278May 15, 2011 - Oct 30, 2013
    Role: Principal Investigator
    Functional Characterization of CXCL14, CXCL17, and CCL28;three mucosal chemokine
    NIH/NIAID R21AI083540Jul 15, 2009 - Dec 30, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Srivastava R, Hernández-Ruiz M, Khan AA, Fouladi MA, Kim GJ, Ly VT, Yamada T, Lam C, Sarain SAB, Boldbaatar U, Zlotnik A, Bahraoui E, BenMohamed L. CXCL17 Chemokine-Dependent Mobilization of CXCR8+CD8+ Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes. J Immunol. 2018 Apr 15; 200(8):2915-2926. PMID: 29549178.
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    2. Bünemann E, Hoff NP, Buhren BA, Wiesner U, Meller S, Bölke E, Müller-Homey A, Kubitza R, Ruzicka T, Zlotnik A, Homey B, Gerber PA. Chemokine ligand-receptor interactions critically regulate cutaneous wound healing. Eur J Med Res. 2018 Jan 16; 23(1):4. PMID: 29338773.
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    3. Catalan-Dibene J, Vazquez MI, Luu VP, Nuccio SP, Karimzadeh A, Kastenschmidt JM, Villalta SA, Ushach I, Pone EJ, Casali P, Raffatellu M, Burkhardt AM, Hernandez-Ruiz M, Heller G, Hevezi PA, Zlotnik A. Identification of IL-40, a Novel B Cell-Associated Cytokine. J Immunol. 2017 11 01; 199(9):3326-3335. PMID: 28978694.
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    4. Aguirre-Guillén WA, Angeles-Floriano T, López-Martínez B, Reyes-Morales H, Zlotnik A, Valle-Rios R. Omics techniques and biobanks to find new biomarkers for the early detection of acute lymphoblastic leukemia in middle-income countries: a perspective from Mexico. Bol Med Hosp Infant Mex. 2017 May - Jun; 74(3):227-232. PMID: 29382491.
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    5. Hernández-Ruiz M, Zlotnik A, Llorente L, Hernandez-Molina G. Markedly high salivary and lacrimal CXCL17 levels in primary Sjögren's syndrome. Joint Bone Spine. 2018 May; 85(3):379-380. PMID: 28532820.
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    6. Dotsey E, Ushach I, Pone E, Nakajima R, Jasinskas A, Argueta DA, Dillon A, DiPatrizio N, Davies H, Zlotnik A, Crompton PD, Felgner PL. Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice. Sci Rep. 2017 Feb 17; 7:42584. PMID: 28209996.
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    7. Hernández-Ruiz M, Zlotnik A. Mucosal Chemokines. J Interferon Cytokine Res. 2017 Feb; 37(2):62-70. PMID: 28207301.
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    8. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A. Pillars Article: IL-10 Acts on the Antigen-presenting Cell to Inhibit Cytokine Production by Thl Cells. J. Immunol. 1991. 146: 3444-3451. J Immunol. 2016 09 01; 197(5):1531-8. PMID: 27543666.
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    9. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. Pillars Article: IL-10 Inhibits Cytokine Production by Activated Macrophages. J. Immunol. 1991. 147: 3815-3822. J Immunol. 2016 09 01; 197(5):1539-46. PMID: 27543667.
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    10. Ushach I, Zlotnik A. Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage. J Leukoc Biol. 2016 09; 100(3):481-9. PMID: 27354413; PMCID: PMC4982611 [Available on 09/01/17].
    11. Morán J, Ramírez-Martínez G, Jiménez-Alvarez L, Cruz A, Pérez-Patrigeon S, Hidalgo A, Orozco L, Martínez A, Padilla-Noriega L, Avila-Moreno F, Cabello C, Granados J, Ortíz-Quintero B, Ramírez-Venegas A, Ruíz-Palacios GM, Zlotnik A, Merino E, Zúñiga J. Circulating levels of miR-150 are associated with poorer outcomes of A/H1N1 infection. Exp Mol Pathol. 2015 Oct; 99(2):253-61. PMID: 26148929.
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    12. Vazquez MI, Catalan-Dibene J, Zlotnik A. B cells responses and cytokine production are regulated by their immune microenvironment. Cytokine. 2015 Aug; 74(2):318-26. PMID: 25742773; PMCID: PMC4475485.
    13. Hernandez-Molina G, Burkhardt AM, Lima G, Zlotnik A, Betanzos JL, Bahena S, Llorente L. Absence of salivary CCL28 in primary Sjögren's syndrome. Rheumatol Int. 2015 Aug; 35(8):1431-4. PMID: 25567740.
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    14. Ushach I, Burkhardt AM, Martinez C, Hevezi PA, Gerber PA, Buhren BA, Schrumpf H, Valle-Rios R, Vazquez MI, Homey B, Zlotnik A. METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages. Clin Immunol. 2015 Feb; 156(2):119-27. PMID: 25486603; PMCID: PMC4336607.
    15. Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A. Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17. J Immunol. 2015 Jan 01; 194(1):29-33. PMID: 25411203; PMCID: PMC4355404.
    16. Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. PLoS One. 2014; 9(8):e105926. PMID: 25165868; PMCID: PMC4148356.
    17. Burkhardt AM, Maravillas-Montero JL, Carnevale CD, Vilches-Cisneros N, Flores JP, Hevezi PA, Zlotnik A. CXCL17 is a major chemotactic factor for lung macrophages. J Immunol. 2014 Aug 01; 193(3):1468-74. PMID: 24973458; PMCID: PMC4142799.
    18. Valle-Rios R, Maravillas-Montero JL, Burkhardt AM, Martinez C, Buhren BA, Homey B, Gerber PA, Robinson O, Hevezi P, Zlotnik A. Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells. J Interferon Cytokine Res. 2014 Oct; 34(10):795-801. PMID: 24956034; PMCID: PMC4186767.
    19. Gerber PA, Buhren BA, Schrumpf H, Homey B, Zlotnik A, Hevezi P. The top skin-associated genes: a comparative analysis of human and mouse skin transcriptomes. Biol Chem. 2014 Jun; 395(6):577-91. PMID: 24497224.
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    20. Luu VP, Vazquez MI, Zlotnik A. B cells participate in tolerance and autoimmunity through cytokine production. Autoimmunity. 2014 Feb; 47(1):1-12. PMID: 24245950.
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    21. Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2014; 66(1):1-79. PMID: 24218476.
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    22. Luu VP, Hevezi P, Vences-Catalan F, Maravillas-Montero JL, White CA, Casali P, Llorente L, Jakez-Ocampo J, Lima G, Vilches-Cisneros N, Flores-Gutiérrez JP, Santos-Argumedo L, Zlotnik A. TSPAN33 is a novel marker of activated and malignant B cells. Clin Immunol. 2013 Dec; 149(3):388-99. PMID: 24211713; PMCID: PMC3956131.
    23. Burkhardt AM, Zlotnik A. Translating translational research: mouse models of human disease. Cell Mol Immunol. 2013 Sep; 10(5):373-4. PMID: 23934028; PMCID: PMC4003194.
    24. Gerber PA, Hevezi P, Buhren BA, Martinez C, Schrumpf H, Gasis M, Grether-Beck S, Krutmann J, Homey B, Zlotnik A. Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins. PLoS One. 2013; 8(6):e63949. PMID: 23840300; PMCID: PMC3688712.
    25. Gaspar K, Kukova G, Bunemann E, Buhren BA, Sonkoly E, Szollosi AG, Muller A, Savinko T, Lauerma AI, Alenius H, Kemeny L, Dieu-Nosjean MC, Stander S, Fischer JW, Ruzicka T, Zlotnik A, Szegedi A, Homey B. The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation. J Dermatol Sci. 2013 Jul; 71(1):12-21. PMID: 23702389.
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    26. Laquer VT, Hevezi PA, Albrecht H, Chen TS, Zlotnik A, Kelly KM. Microarray analysis of port wine stains before and after pulsed dye laser treatment. Lasers Surg Med. 2013 Feb; 45(2):67-75. PMID: 23440713; PMCID: PMC3930171.
    27. Godfrey DI, Kennedy J, Suda T, Zlotnik A. Pillars article: a developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 1993. 150: 4244-4252. J Immunol. 2012 Nov 01; 189(9):4203-11. PMID: 23087425.
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    28. Zlotnik A, Yoshie O. The chemokine superfamily revisited. Immunity. 2012 May 25; 36(5):705-16. PMID: 22633458; PMCID: PMC3396424.
    29. Burkhardt AM, Tai KP, Flores-Guiterrez JP, Vilches-Cisneros N, Kamdar K, Barbosa-Quintana O, Valle-Rios R, Hevezi PA, Zuñiga J, Selman M, Ouellette AJ, Zlotnik A. CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity. J Immunol. 2012 Jun 15; 188(12):6399-406. PMID: 22611239; PMCID: PMC3370106.
    30. Zlotnik A, Burkhardt AM, Homey B. Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol. 2011 Aug 25; 11(9):597-606. PMID: 21866172.
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    31. Hevezi PA, Tom E, Wilson K, Lambert P, Gutierrez-Reyes G, Kershenobich D, Zlotnik A. Gene expression patterns in livers of Hispanic patients infected with hepatitis C virus. Autoimmunity. 2011 Nov; 44(7):532-42. PMID: 21864061.
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    32. Zúñiga J, Torres M, Romo J, Torres D, Jiménez L, Ramírez G, Cruz A, Espinosa E, Herrera T, Buendía I, Ramírez-Venegas A, González Y, Bobadilla K, Hernández F, García J, Quiñones-Falconi F, Sada E, Manjarrez ME, Cabello C, Kawa S, Zlotnik A, Pardo A, Selman M. Inflammatory profiles in severe pneumonia associated with the pandemic influenza A/H1N1 virus isolated in Mexico City. Autoimmunity. 2011 Nov; 44(7):562-70. PMID: 21838592.
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    33. Zlotnik A. Autoimmunity in Hispanic patients. Preface. Autoimmunity. 2011 Nov; 44(7):531. PMID: 21689028.
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    34. Wang X, Chow R, Deng L, Anderson D, Weidner N, Godwin AK, Bewtra C, Zlotnik A, Bui J, Varki A, Varki N. Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. Glycobiology. 2011 Aug; 21(8):1038-48. PMID: 21467073; PMCID: PMC3130538.
    35. Gutierrez-Reyes G, del Carmen Garcia de Leon M, Varela-Fascinetto G, Valencia P, Pérez Tamayo R, Rosado CG, Labonne BF, Rochilin NM, Garcia RM, Valadez JA, Latour GT, Corona DL, Diaz GR, Zlotnik A, Kershenobich D. Cellular senescence in livers from children with end stage liver disease. PLoS One. 2010 Apr 21; 5(4):e10231. PMID: 20422055; PMCID: PMC2858078.
    36. Moyer BD, Hevezi P, Gao N, Lu M, Kalabat D, Soto H, Echeverri F, Laita B, Yeh SA, Zoller M, Zlotnik A. Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations. PLoS One. 2009 Dec 04; 4(12):e7682. PMID: 19997627; PMCID: PMC2780358.
    37. Valle-Rios R, Patiño-Lopez G, Medina-Contreras O, Canche-Pool E, Recillas-Targa F, Lopez-Bayghen E, Zlotnik A, Ortiz-Navarrete V. Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. Mol Immunol. 2009 Oct; 46(16):3379-87. PMID: 19695707.
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    38. Hevezi P, Moyer BD, Lu M, Gao N, White E, Echeverri F, Kalabat D, Soto H, Laita B, Li C, Yeh SA, Zoller M, Zlotnik A. Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes. PLoS One. 2009 Jul 28; 4(7):e6395. PMID: 19636377; PMCID: PMC2712080.
    39. Gao N, Lu M, Echeverri F, Laita B, Kalabat D, Williams ME, Hevezi P, Zlotnik A, Moyer BD. Voltage-gated sodium channels in taste bud cells. BMC Neurosci. 2009 Mar 12; 10:20. PMID: 19284629; PMCID: PMC2660338.
    40. Pivarcsi A, Müller A, Hippe A, Rieker J, van Lierop A, Steinhoff M, Seeliger S, Kubitza R, Pippirs U, Meller S, Gerber PA, Liersch R, Buenemann E, Sonkoly E, Wiesner U, Hoffmann TK, Schneider L, Piekorz R, Enderlein E, Reifenberger J, Rohr UP, Haas R, Boukamp P, Haase I, Nürnberg B, Ruzicka T, Zlotnik A, Homey B. Tumor immune escape by the loss of homeostatic chemokine expression. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19055-60. PMID: 18025475; PMCID: PMC2141907.
    41. Hever A, Roth RB, Hevezi P, Marin ME, Acosta JA, Acosta H, Rojas J, Herrera R, Grigoriadis D, White E, Conlon PJ, Maki RA, Zlotnik A. Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12451-6. PMID: 17640886; PMCID: PMC1941489.
    42. Meller S, Lauerma AI, Kopp FM, Winterberg F, Anthoni M, Müller A, Gombert M, Haahtela A, Alenius H, Rieker J, Dieu-Nosjean MC, Kubitza RC, Gleichmann E, Ruzicka T, Zlotnik A, Homey B. Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference. J Allergy Clin Immunol. 2007 Jun; 119(6):1470-80. PMID: 17337293.
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    43. Zlotnik A. Chemokines and cancer. Int J Cancer. 2006 Nov 01; 119(9):2026-9. PMID: 16671092.
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    44. Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Int J Cancer. 2006 May 01; 118(9):2147-57. PMID: 16331601.
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    45. Roth RB, Hevezi P, Lee J, Willhite D, Lechner SM, Foster AC, Zlotnik A. Gene expression analyses reveal molecular relationships among 20 regions of the human CNS. Neurogenetics. 2006 May; 7(2):67-80. PMID: 16572319.
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    46. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J, Steinhoff M, Hoffmann TK, Ruzicka T, Zlotnik A, Homey B. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol. 2006 Feb; 117(2):411-7. PMID: 16461142.
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    47. Zlotnik A. Involvement of chemokine receptors in organ-specific metastasis. Contrib Microbiol. 2006; 13:191-9. PMID: 16627966.
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    48. Zlotnik A, Yoshie O, Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol. 2006; 7(12):243. PMID: 17201934; PMCID: PMC1794421.
    49. Patiño-Lopez G, Hevezi P, Lee J, Willhite D, Verge GM, Lechner SM, Ortiz-Navarrete V, Zlotnik A. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. J Neuroimmunol. 2006 Feb; 171(1-2):145-55. PMID: 16300832.
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    50. Selman M, Pardo A, Barrera L, Estrada A, Watson SR, Wilson K, Aziz N, Kaminski N, Zlotnik A. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2006 Jan 15; 173(2):188-98. PMID: 16166619; PMCID: PMC2662988.
    51. Lee J, Hever A, Willhite D, Zlotnik A, Hevezi P. Effects of RNA degradation on gene expression analysis of human postmortem tissues. FASEB J. 2005 Aug; 19(10):1356-8. PMID: 15955843.
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    52. Meller S, Winterberg F, Gilliet M, Müller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bünemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum. 2005 May; 52(5):1504-16. PMID: 15880822.
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    53. Gombert M, Dieu-Nosjean MC, Winterberg F, Bünemann E, Kubitza RC, Da Cunha L, Haahtela A, Lehtimäki S, Müller A, Rieker J, Meller S, Pivarcsi A, Koreck A, Fridman WH, Zentgraf HW, Pavenstädt H, Amara A, Caux C, Kemeny L, Alenius H, Lauerma A, Ruzicka T, Zlotnik A, Homey B. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J Immunol. 2005 Apr 15; 174(8):5082-91. PMID: 15814739.
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    54. Heise CE, Pahuja A, Hudson SC, Mistry MS, Putnam AL, Gross MM, Gottlieb PA, Wade WS, Kiankarimi M, Schwarz D, Crowe P, Zlotnik A, Alleva DG. Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun; 313(3):1263-71. PMID: 15761110.
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    55. Pivarcsi A, Gombert M, Dieu-Nosjean MC, Lauerma A, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A, Homey B. CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J Immunol. 2004 Nov 01; 173(9):5810-7. PMID: 15494534.
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    56. Zlotnik A. Chemokines in neoplastic progression. Semin Cancer Biol. 2004 Jun; 14(3):181-5. PMID: 15246053.
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    57. Houshmand P, Zlotnik A. Targeting tumor cells. Curr Opin Cell Biol. 2003 Oct; 15(5):640-4. PMID: 14519400.
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    58. Houshmand P, Zlotnik A. Therapeutic applications in the chemokine superfamily. Curr Opin Chem Biol. 2003 Aug; 7(4):457-60. PMID: 12941419.
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    59. Zlotnik A. Chemokines and chemokine receptors--Keystone Symposium highlights 7-12 January 2003, Breckenridge, CO, USA. IDrugs. 2003 Mar; 6(3):195-6. PMID: 12841177.
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    60. Bacon K, Baggiolini M, Broxmeyer H, Horuk R, Lindley I, Mantovani A, Maysushima K, Murphy P, Nomiyama H, Oppenheim J, Rot A, Schall T, Tsang M, Thorpe R, Van Damme J, Wadhwa M, Yoshie O, Zlotnik A, Zoon K. Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res. 2002 Oct; 22(10):1067-8. PMID: 12433287.
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    61. Emtage PC, Xing Z, Wan Y, Zlotnik A, Graham FL, Gauldie J. Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells. J Interferon Cytokine Res. 2002 May; 22(5):573-82. PMID: 12060496.
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    62. Homey B, Müller A, Zlotnik A. Chemokines: agents for the immunotherapy of cancer? Nat Rev Immunol. 2002 Mar; 2(3):175-84. PMID: 11913068.
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    63. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med. 2002 Feb; 8(2):157-65. PMID: 11821900.
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    64. Chen SC, Leach MW, Chen Y, Cai XY, Sullivan L, Wiekowski M, Dovey-Hartman BJ, Zlotnik A, Lira SA. Central nervous system inflammation and neurological disease in transgenic mice expressing the CC chemokine CCL21 in oligodendrocytes. J Immunol. 2002 Feb 01; 168(3):1009-17. PMID: 11801633.
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