Loading...

Steward, Oswald

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentAnatomy and Neurobiology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8908
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Towards a therapy to regenerate corticospinal axons
    NIH/NINDS R01NS073857Aug 15, 2011 - May 31, 2016
    Role: Principal Investigator
    A novel pathway mediating the development of chronic orofacial neuropathic pain
    NIH/NIDCR R01DE021847Apr 7, 2011 - Feb 29, 2016
    Role: Co-Principal Investigator
    Axon Regeneration after Spinal Cord Injury in Mice
    NIH/NINDS R01NS047718Aug 15, 2005 - May 31, 2011
    Role: Principal Investigator
    Summer Training Program in Neuroscience
    NIH/NINDS T35NS045563Jul 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    Postdoctoral Training Program in Neural Regeneration
    NIH/NINDS T32NS007486Jul 15, 2001 - Jun 30, 2007
    Role: Principal Investigator
    GENETIC APPROACH TO CNS REGENERATION RESEARCH
    NIH/NINDS R01NS032280Dec 1, 1994 - Jun 30, 2003
    Role: Principal Investigator
    Predoctoral Training in Neuroscience
    NIH/NIGMS T32GM008328Jul 1, 1992 - Jun 30, 2018
    Role: Co-Principal Investigator
    REGULATION OF ASTROGLIAL GENE EXPRESSION
    NIH/NINDS R01NS029875Aug 1, 1991 - Aug 31, 1999
    Role: Principal Investigator
    NEUROPLASTICITY AND REGENERATION RESEARCH
    NIH/NINDS T32NS007199Jul 1, 1981 - Jun 30, 1997
    Role: Principal Investigator
    Localization of mRNAs at Synaptic Sites on Dendrites
    NIH/NINDS R01NS012333Jun 1, 1978 - Nov 30, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Gallaher ZR, Steward O. Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice. Exp Neurol. 2018 May; 303:120-133. PMID: 29458059.
      View in: PubMed
    2. Steward O, Matsudaira Yee K, Farris S, Pirbhoy PS, Worley P, Okamura K, Okuno H, Bito H. Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice. Front Mol Neurosci. 2017; 10:435. PMID: 29445324.
      View in: PubMed
    3. Gallent EA, Steward O. Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons. Exp Neurol. 2018 May; 303:12-28. PMID: 29337147.
      View in: PubMed
    4. Pirbhoy PS, Farris S, Steward O. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem. 2017 Aug; 24(8):341-357. PMID: 28716954.
      View in: PubMed
    5. Kang YJ, Tian G, Bazrafkan A, Farahabadi MH, Azadian M, Abbasi H, Shamaoun BE, Steward O, Akbari Y. Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway. J Neurotrauma. 2017 Oct 01; 34(19):2823-2832. PMID: 28447885.
      View in: PubMed
    6. Gutilla EA, Steward O. Selective neuronal PTEN deletion: can we take the brakes off of growth without losing control? Neural Regen Res. 2016 Aug; 11(8):1201-3. PMID: 27651754; PMCID: PMC5020805.
    7. Steward O. A Rhumba of "R's": Replication, Reproducibility, Rigor, Robustness: What Does a Failure to Replicate Mean? eNeuro. 2016 Jul-Aug; 3(4). PMID: 27419220; PMCID: PMC4937130.
    8. Steward O, Willenberg R. Rodent spinal cord injury models for studies of axon regeneration. Exp Neurol. 2017 Jan; 287(Pt 3):374-383. PMID: 27374113.
      View in: PubMed
    9. Pirbhoy PS, Farris S, Steward O. Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains. Learn Mem. 2016 06; 23(6):255-69. PMID: 27194793; PMCID: PMC4880148 [Available on 06/01/17].
    10. Park J, Yu YP, Zhou CY, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Eroglu C, Barres B, Zaucke F, Feng G, Luo ZD. Central Mechanisms Mediating Thrombospondin-4-induced Pain States. J Biol Chem. 2016 Jun 17; 291(25):13335-48. PMID: 27129212; PMCID: PMC4933243 [Available on 06/17/17].
    11. Willenberg R, Zukor K, Liu K, He Z, Steward O. Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down. J Comp Neurol. 2016 Sep 01; 524(13):2654-76. PMID: 26878190; PMCID: PMC4935643 [Available on 09/01/17].
    12. Gutilla EA, Buyukozturk MM, Steward O. Long-term consequences of conditional genetic deletion of PTEN in the sensorimotor cortex of neonatal mice. Exp Neurol. 2016 May; 279:27-39. PMID: 26896833; PMCID: PMC4957975 [Available on 05/01/17].
    13. Sharp KG, Duarte JE, Gebrekristos B, Perez S, Steward O, Reinkensmeyer DJ. Robotic Rehabilitator of the Rodent Upper Extremity: A System and Method for Assessing and Training Forelimb Force Production after Neurological Injury. J Neurotrauma. 2016 Mar 01; 33(5):460-7. PMID: 26414700; PMCID: PMC4779318 [Available on 03/01/17].
    14. Blanc CA, Grist JJ, Rosen H, Sears-Kraxberger I, Steward O, Lane TE. Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination. Am J Pathol. 2015 Oct; 185(10):2819-32. PMID: 26435414; PMCID: PMC4607760 [Available on 10/01/16].
    15. Willenberg R, Steward O. Nonspecific labeling limits the utility of Cre-Lox bred CST-YFP mice for studies of corticospinal tract regeneration. J Comp Neurol. 2015 Dec 15; 523(18):2665-82. PMID: 25976033; PMCID: PMC4607560 [Available on 12/15/16].
    16. Park J, Trinh VN, Sears-Kraxberger I, Li KW, Steward O, Luo ZD. Synaptic ultrastructure changes in trigeminocervical complex posttrigeminal nerve injury. J Comp Neurol. 2016 Feb 01; 524(2):309-22. PMID: 26132987; PMCID: PMC4675675 [Available on 02/01/17].
    17. Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015 Jul; 269:154-68. PMID: 25902036.
      View in: PubMed
    18. Danilov CA, Steward O. Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice. Exp Neurol. 2015 Apr; 266:147-60. PMID: 25704959; PMCID: PMC4382431.
    19. Bonner JF, Steward O. Repair of spinal cord injury with neuronal relays: From fetal grafts to neural stem cells. Brain Res. 2015 Sep 04; 1619:115-23. PMID: 25591483; PMCID: PMC4499497.
    20. Steward O, Farris S, Pirbhoy PS, Darnell J, Driesche SJ. Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes. Front Mol Neurosci. 2014; 7:101. PMID: 25628532; PMCID: PMC4290588.
    21. Steward O, Balice-Gordon R. Rigor or mortis: best practices for preclinical research in neuroscience. Neuron. 2014 Nov 05; 84(3):572-81. PMID: 25442936.
      View in: PubMed
    22. Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, Reggie Edgerton V, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Res. 2015 Sep 04; 1619:124-38. PMID: 25451131; PMCID: PMC4418964.
    23. Steward O, Sharp KG, Yee KM, Hatch MN, Bonner JF. Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury. J Neurosci. 2014 Oct 15; 34(42):14013-21. PMID: 25319698; PMCID: PMC4198542.
    24. Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. Development of a database for translational spinal cord injury research. J Neurotrauma. 2014 Nov 01; 31(21):1789-99. PMID: 25077610; PMCID: PMC4186058.
    25. Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW. Rapamycin and interleukin-1ß impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem. 2014 Jul 25; 289(30):20615-29. PMID: 24917666; PMCID: PMC4110274.
    26. Lewandowski G, Steward O. AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. J Neurosci. 2014 Jul 23; 34(30):9951-62. PMID: 25057197; PMCID: PMC4107411.
    27. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37. PMID: 24936469; PMCID: PMC4050357.
    28. Sharp KG, Yee KM, Steward O. A re-assessment of long distance growth and connectivity of neural stem cells after severe spinal cord injury. Exp Neurol. 2014 Jul; 257:186-204. PMID: 24747827.
      View in: PubMed
    29. Farris S, Lewandowski G, Cox CD, Steward O. Selective localization of arc mRNA in dendrites involves activity- and translation-dependent mRNA degradation. J Neurosci. 2014 Mar 26; 34(13):4481-93. PMID: 24671994; PMCID: PMC3965778.
    30. Steward O, Sharp KG, Matsudaira Yee K. Long-distance migration and colonization of transplanted neural stem cells. Cell. 2014 Jan 30; 156(3):385-7. PMID: 24485444.
      View in: PubMed
    31. Li KW, Yu YP, Zhou C, Kim DS, Lin B, Sharp K, Steward O, Luo ZD. Calcium channel a2d1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. J Biol Chem. 2014 Mar 07; 289(10):7025-37. PMID: 24459143; PMCID: PMC3945363.
    32. Sharp KG, Yee KM, Steward O. A re-assessment of treatment with a tyrosine kinase inhibitor (imatinib) on tissue sparing and functional recovery after spinal cord injury. Exp Neurol. 2014 Apr; 254:1-11. PMID: 24440639.
      View in: PubMed
    33. Sharp KG, Yee KM, Stiles TL, Aguilar RM, Steward O. A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury. Exp Neurol. 2013 Oct; 248:321-37. PMID: 23830951.
      View in: PubMed
    34. Chao T, Frump D, Lin M, Caiozzo VJ, Mozaffar T, Steward O, Gupta R. Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury. Ann Neurol. 2013 Feb; 73(2):210-23. PMID: 23281061.
      View in: PubMed
    35. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11; 490(7419):187-91. PMID: 23060188.
      View in: PubMed
    36. Dynes JL, Steward O. Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation. J Comp Neurol. 2012 Oct 01; 520(14):3105-19. PMID: 22350812.
      View in: PubMed
    37. Lin MY, Frieboes LS, Forootan M, Palispis WA, Mozaffar T, Jafari M, Steward O, Gall CM, Gupta R. Biophysical stimulation induces demyelination via an integrin-dependent mechanism. Ann Neurol. 2012 Jul; 72(1):112-23. PMID: 22829273.
      View in: PubMed
    38. Kim DS, Li KW, Boroujerdi A, Peter Yu Y, Zhou CY, Deng P, Park J, Zhang X, Lee J, Corpe M, Sharp K, Steward O, Eroglu C, Barres B, Zaucke F, Xu ZC, Luo ZD. Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. J Neurosci. 2012 Jun 27; 32(26):8977-87. PMID: 22745497; PMCID: PMC3408211.
    39. Tuszynski MH, Steward O. Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 07; 74(5):777-91. PMID: 22681683; PMCID: PMC3387806.
    40. Oropallo MA, Held KS, Goenka R, Ahmad SA, O'Neill PJ, Steward O, Lane TE, Cancro MP. Chronic spinal cord injury impairs primary antibody responses but spares existing humoral immunity in mice. J Immunol. 2012 Jun 01; 188(11):5257-66. PMID: 22523388; PMCID: PMC3358463.
    41. Sharp KG, Dickson AR, Marchenko SA, Yee KM, Emery PN, Laidmåe I, Uibo R, Sawyer ES, Steward O, Flanagan LA. Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation. Exp Neurol. 2012 May; 235(1):345-56. PMID: 22414309; PMCID: PMC3437931.
    42. Sharp K, Boroujerdi A, Steward O, Luo ZD. A rat chronic pain model of spinal cord contusion injury. Methods Mol Biol. 2012; 851:195-203. PMID: 22351092.
      View in: PubMed
    43. Strong MK, Southwell AL, Yonan JM, Hayden MR, Macgregor GR, Thompson LM, Steward O. Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background. J Huntingtons Dis. 2012; 1(2):221-41. PMID: 23833693; PMCID: PMC3702054.
    44. Wong JK, Steward O. One day of motor training with amphetamine impairs motor recovery following spinal cord injury. Exp Neurol. 2012 Feb; 233(2):693-707. PMID: 22078754.
      View in: PubMed
    45. Steward O, Popovich PG, Dietrich WD, Kleitman N. Replication and reproducibility in spinal cord injury research. Exp Neurol. 2012 Feb; 233(2):597-605. PMID: 22078756.
      View in: PubMed
    46. Sharp K, Yee KM, Steward O. A re-assessment of the effects of treatment with an epidermal growth factor receptor (EGFR) inhibitor on recovery of bladder and locomotor function following thoracic spinal cord injury in rats. Exp Neurol. 2012 Feb; 233(2):649-59. PMID: 22078761.
      View in: PubMed
    47. Nielson JL, Strong MK, Steward O. A reassessment of whether cortical motor neurons die following spinal cord injury. J Comp Neurol. 2011 Oct 01; 519(14):2852-69. PMID: 21618218; PMCID: PMC3916191.
    48. Steward O, Sharp K, Yee KM. A re-assessment of the effects of intracortical delivery of inosine on transmidline growth of corticospinal tract axons after unilateral lesions of the medullary pyramid. Exp Neurol. 2012 Feb; 233(2):662-73. PMID: 21946267; PMCID: PMC3652674.
    49. Boroujerdi A, Zeng J, Sharp K, Kim D, Steward O, Luo ZD. Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. Pain. 2011 Mar; 152(3):649-55. PMID: 21239111; PMCID: PMC3039050.
    50. Sharp KG, Flanagan LA, Yee KM, Steward O. A re-assessment of a combinatorial treatment involving Schwann cell transplants and elevation of cyclic AMP on recovery of motor function following thoracic spinal cord injury in rats. Exp Neurol. 2012 Feb; 233(2):625-44. PMID: 21195070.
      View in: PubMed
    51. Huntley GW, Elste AM, Patil SB, Bozdagi O, Benson DL, Steward O. Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus. 2012 Jan; 22(1):17-28. PMID: 20848607; PMCID: PMC3008765.
    52. Held KS, Steward O, Blanc C, Lane TE. Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Exp Neurol. 2010 Nov; 226(1):242-53. PMID: 20832407.
      View in: PubMed
    53. Nielson JL, Sears-Kraxberger I, Strong MK, Wong JK, Willenberg R, Steward O. Unexpected survival of neurons of origin of the pyramidal tract after spinal cord injury. J Neurosci. 2010 Aug 25; 30(34):11516-28. PMID: 20739574; PMCID: PMC2941508.
    54. David BT, Steward O. Deficits in bladder function following spinal cord injury vary depending on the level of the injury. Exp Neurol. 2010 Nov; 226(1):128-35. PMID: 20713043; PMCID: PMC2955760.
    55. Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010 Sep; 13(9):1075-81. PMID: 20694004; PMCID: PMC2928871.
    56. Hellman AN, Vahidi B, Kim HJ, Mismar W, Steward O, Jeon NL, Venugopalan V. Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection. Lab Chip. 2010 Aug 21; 10(16):2083-92. PMID: 20532390; PMCID: PMC3380453.
    57. Smith JS, Anderson R, Pham T, Bhatia N, Steward O, Gupta R. Role of early surgical decompression of the intradural space after cervical spinal cord injury in an animal model. J Bone Joint Surg Am. 2010 May; 92(5):1206-14. PMID: 20439667; PMCID: PMC2859904.
    58. Gupta R, Bathen ME, Smith JS, Levi AD, Bhatia NN, Steward O. Advances in the management of spinal cord injury. J Am Acad Orthop Surg. 2010 Apr; 18(4):210-22. PMID: 20357230.
      View in: PubMed
    59. Chotiner JK, Nielson J, Farris S, Lewandowski G, Huang F, Banos K, de Leon R, Steward O. Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem. 2010 Feb; 17(2):117-29. PMID: 20154358; PMCID: PMC2825695.
    60. Aguilar RM, Steward O. A bilateral cervical contusion injury model in mice: assessment of gripping strength as a measure of forelimb motor function. Exp Neurol. 2010 Jan; 221(1):38-53. PMID: 19815010; PMCID: PMC2812629.
    61. Anderson KD, Sharp KG, Hofstadter M, Irvine KA, Murray M, Steward O. Forelimb locomotor assessment scale (FLAS): novel assessment of forelimb dysfunction after cervical spinal cord injury. Exp Neurol. 2009 Nov; 220(1):23-33. PMID: 19733168; PMCID: PMC2771771.
    62. Anderson KD, Sharp KG, Steward O. Bilateral cervical contusion spinal cord injury in rats. Exp Neurol. 2009 Nov; 220(1):9-22. PMID: 19559699; PMCID: PMC2761499.
    63. Wong JK, Sharp K, Steward O. A straight alley version of the BBB locomotor scale. Exp Neurol. 2009 Jun; 217(2):417-20. PMID: 19348792; PMCID: PMC2703578.
    64. Strong MK, Blanco JE, Anderson KD, Lewandowski G, Lewandoski G, Steward O. An investigation of the cortical control of forepaw gripping after cervical hemisection injuries in rats. Exp Neurol. 2009 May; 217(1):96-107. PMID: 19416669; PMCID: PMC2679860.
    65. Miyashita T, Kubik S, Haghighi N, Steward O, Guzowski JF. Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience. J Neurosci. 2009 Jan 28; 29(4):898-906. PMID: 19176799; PMCID: PMC2749324.
    66. Liu Y, Wang X, Lu CC, Kerman R, Steward O, Xu XM, Zou Y. Repulsive Wnt signaling inhibits axon regeneration after CNS injury. J Neurosci. 2008 Aug 13; 28(33):8376-82. PMID: 18701700; PMCID: PMC3385642.
    67. Steward O, Zheng B, Tessier-Lavigne M, Hofstadter M, Sharp K, Yee KM. Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J Neurosci. 2008 Jul 02; 28(27):6836-47. PMID: 18596159; PMCID: PMC2745399.
    68. Chao T, Pham K, Steward O, Gupta R. Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J Comp Neurol. 2008 Jan 10; 506(2):180-93. PMID: 18022951.
      View in: PubMed
    69. Steward O, Sharp K, Yee KM, Hofstadter M. A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol. 2008 Feb; 209(2):446-68. PMID: 18234196; PMCID: PMC2613794.
    70. McLin JP, Thompson LM, Lusis AJ, Davis RC, Steward O. Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid. Neurobiol Dis. 2008 Mar; 29(3):391-9. PMID: 17996456.
      View in: PubMed
    71. Huang F, Chotiner JK, Steward O. Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci. 2007 Aug 22; 27(34):9054-67. PMID: 17715342.
      View in: PubMed
    72. Steward O, Huang F, Guzowski JF. A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction. Learn Mem. 2007 Jun; 14(6):433-45. PMID: 17562895; PMCID: PMC1896093.
    73. Anderson KD, Gunawan A, Steward O. Spinal pathways involved in the control of forelimb motor function in rats. Exp Neurol. 2007 Aug; 206(2):318-31. PMID: 17603042.
      View in: PubMed
    74. Steward O, Zheng B, Banos K, Yee KM. Response to: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199. Neuron. 2007 Apr 19; 54(2):191-5. PMID: 17442241.
      View in: PubMed
    75. Dynes JL, Steward O. Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites. J Comp Neurol. 2007 Jan 20; 500(3):433-47. PMID: 17120280.
      View in: PubMed
    76. McLin JP, Thompson LM, Steward O. Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains. Eur J Neurosci. 2006 Dec; 24(11):3134-40. PMID: 17156374.
      View in: PubMed
    77. Blanco JE, Anderson KD, Steward O. Recovery of forepaw gripping ability and reorganization of cortical motor control following cervical spinal cord injuries in mice. Exp Neurol. 2007 Feb; 203(2):333-48. PMID: 17049345.
      View in: PubMed
    78. McLin JP, Steward O. Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. Eur J Neurosci. 2006 Oct; 24(8):2191-202. PMID: 17074044.
      View in: PubMed
    79. Schuman EM, Dynes JL, Steward O. Synaptic regulation of translation of dendritic mRNAs. J Neurosci. 2006 Jul 05; 26(27):7143-6. PMID: 16822969.
      View in: PubMed
    80. Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, Mozaffar T, Steward O. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Exp Neurol. 2006 Aug; 200(2):418-29. PMID: 16764860.
      View in: PubMed
    81. Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. PMID: 16495442.
      View in: PubMed
    82. Steward O, Sharp K, Selvan G, Hadden A, Hofstadter M, Au E, Roskams J. A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats. Exp Neurol. 2006 Apr; 198(2):483-99. PMID: 16494866.
      View in: PubMed
    83. Power AE, Berlau DJ, McGaugh JL, Steward O. Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration. Learn Mem. 2006 Jan-Feb; 13(1):27-34. PMID: 16452651; PMCID: PMC1360130.
    84. Radojicic M, Reier PJ, Steward O, Keirstead HS. Septations in chronic spinal cord injury cavities contain axons. Exp Neurol. 2005 Dec; 196(2):339-41. PMID: 16153640.
      View in: PubMed
    85. Huang F, Chotiner JK, Steward O. The mRNA for elongation factor 1alpha is localized in dendrites and translated in response to treatments that induce long-term depression. J Neurosci. 2005 Aug 03; 25(31):7199-209. PMID: 16079402.
      View in: PubMed
    86. McIntyre CK, Miyashita T, Setlow B, Marjon KD, Steward O, Guzowski JF, McGaugh JL. Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10718-23. PMID: 16020527; PMCID: PMC1175582.
    87. Keirstead HS, Fedulov V, Cloutier F, Steward O, Duel BP. A noninvasive ultrasonographic method to evaluate bladder function recovery in spinal cord injured rats. Exp Neurol. 2005 Jul; 194(1):120-7. PMID: 15899249.
      View in: PubMed
    88. Anderson KD, Gunawan A, Steward O. Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract. Exp Neurol. 2005 Jul; 194(1):161-74. PMID: 15899253.
      View in: PubMed
    89. Gupta R, Rummler L, Steward O. Understanding the biology of compressive neuropathies. Clin Orthop Relat Res. 2005 Jul; (436):251-60. PMID: 15995449.
      View in: PubMed
    90. Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, Steward O. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 2005 May 11; 25(19):4694-705. PMID: 15888645.
      View in: PubMed
    91. Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, Tessier-Lavigne M. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1205-10. PMID: 15647357; PMCID: PMC544342.
    92. Anderson KD, Abdul M, Steward O. Quantitative assessment of deficits and recovery of forelimb motor function after cervical spinal cord injury in mice. Exp Neurol. 2004 Nov; 190(1):184-91. PMID: 15473991.
      View in: PubMed
    93. Brown MR, Sullivan PG, Dorenbos KA, Modafferi EA, Geddes JW, Steward O. Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria. J Neurosci Methods. 2004 Aug 30; 137(2):299-303. PMID: 15262074.
      View in: PubMed
    94. Tongiorgi E, Armellin M, Giulianini PG, Bregola G, Zucchini S, Paradiso B, Steward O, Cattaneo A, Simonato M. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J Neurosci. 2004 Jul 28; 24(30):6842-52. PMID: 15282290.
      View in: PubMed
    95. Gupta R, Rowshan K, Chao T, Mozaffar T, Steward O. Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp Neurol. 2004 Jun; 187(2):500-8. PMID: 15144876.
      View in: PubMed
    96. Steward O, Zheng B, Ho C, Anderson K, Tessier-Lavigne M. The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J Comp Neurol. 2004 May 10; 472(4):463-77. PMID: 15065120.
      View in: PubMed
    97. Oishi Y, Baratta J, Robertson RT, Steward O. Assessment of factors regulating axon growth between the cortex and spinal cord in organotypic co-cultures: effects of age and neurotrophic factors. J Neurotrauma. 2004 Mar; 21(3):339-56. PMID: 15115608.
      View in: PubMed
    98. Steward O. The successful aging of Carl Cotman: from proteins of the synapse, through sprouting, regeneration, and spinal cord injury to the mechanisms of brain aging. Neurochem Res. 2003 Nov; 28(11):1617-9. PMID: 14584814.
      View in: PubMed
    99. Steward O, Schuman EM. Compartmentalized synthesis and degradation of proteins in neurons. Neuron. 2003 Oct 09; 40(2):347-59. PMID: 14556713.
      View in: PubMed
    100. Inman DM, Steward O. Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice. J Comp Neurol. 2003 Aug 04; 462(4):431-49. PMID: 12811811.
      View in: PubMed
    101. Gupta R, Steward O. Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J Comp Neurol. 2003 Jun 23; 461(2):174-86. PMID: 12724836.
      View in: PubMed
    102. Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram TZ. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol. 2003 Jun; 53(6):711-7. PMID: 12783416; PMCID: PMC2930774.
    103. Zheng B, Ho C, Li S, Keirstead H, Steward O, Tessier-Lavigne M. Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24; 38(2):213-24. PMID: 12718856.
      View in: PubMed
    104. Steward O, Zheng B, Tessier-Lavigne M. False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol. 2003 Apr 21; 459(1):1-8. PMID: 12629662.
      View in: PubMed
    105. Temple MD, Worley PF, Steward O. Visualizing changes in circuit activity resulting from denervation and reinnervation using immediate early gene expression. J Neurosci. 2003 Apr 01; 23(7):2779-88. PMID: 12684464.
      View in: PubMed
    106. Inman DM, Steward O. Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord. J Neurotrauma. 2003 Jan; 20(1):33-42. PMID: 12614586.
      View in: PubMed
    107. Steward O, Worley P. Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation? Neurobiol Learn Mem. 2002 Nov; 78(3):508-27. PMID: 12559831.
      View in: PubMed
    108. Steward O. mRNA at synapses, synaptic plasticity, and memory consolidation. Neuron. 2002 Oct 24; 36(3):338-40. PMID: 12408837.
      View in: PubMed
    109. Inman D, Guth L, Steward O. Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol. 2002 Sep 23; 451(3):225-35. PMID: 12210135.
      View in: PubMed
    110. Steward O. Translating axon guidance cues. Cell. 2002 Sep 06; 110(5):537-40. PMID: 12230970.
      View in: PubMed
    111. Temple MD, Kosik KS, Steward O. Spatial learning and memory is preserved in rats after early development in a microgravity environment. Neurobiol Learn Mem. 2002 Sep; 78(2):199-216. PMID: 12431413.
      View in: PubMed
    112. Steward O, Worley PF. A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7062-8. PMID: 11416188; PMCID: PMC34623.
    113. Steward O, Worley PF. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron. 2001 Apr; 30(1):227-40. PMID: 11343657.
      View in: PubMed
    114. Steward O, Schuman EM. Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci. 2001; 24:299-325. PMID: 11283313.
      View in: PubMed
    Oswald's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _