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Said, Hamid M.

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
CA 92697-3950
Phone(562) 826-5811
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    Collapse Research 
    Collapse Research Activities and Funding
    Physiological and Pathological Aspects of Intestinal Vitamin B2 Absorption
    VA I01BX001142Apr 1, 2011 - Jun 30, 2020
    Role: Principal Investigator
    Physiology/cell biology of pancreatic acinar mitochondrial vitamin B1 uptake
    NIH/NIAAA R01AA018071May 1, 2009 - Jan 31, 2019
    Role: Principal Investigator
    C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    NIH/NIDDK R21DK075348Sep 8, 2006 - Aug 31, 2009
    Role: Principal Investigator
    INTESTINAL BIOTIN ABSORPTION: PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ASPECTS
    NIH/NIDDK R01DK058057Sep 15, 2000 - Jul 31, 2020
    Role: Principal Investigator
    Mechanism/Regulation of Intestinal Thiamin Uptake
    NIH/NIDDK R37DK056061Aug 1, 1999 - Jul 31, 2019
    Role: Principal Investigator
    Mechanism/regulation of human intestinal thiamin uptake
    NIH/NIDDK R01DK056061Aug 1, 1999 - Jul 31, 2009
    Role: Principal Investigator
    RIBOFLAVIN TRANSPORT IN RENAL PROXIMAL TUBULES
    NIH/NIDDK R01DK047203May 1, 1995 - Apr 30, 2000
    Role: Principal Investigator
    NUTRITIONAL STUDIES ON BIOTON ABSORPTION
    NIH/NIDDK R01DK039501Mar 1, 1988 - Nov 30, 1991
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sabui S, Kapadia R, Ghosal A, Schneider M, Lambrecht N, Said H. Biotin and pantothenic acid over-supplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects. Am J Physiol Cell Physiol. 2018 Apr 18. PMID: 29669219.
      View in: PubMed
    2. Subramanian VS, Sabui S, Subramenium GA, Marchant JS, Said H. Tumor Necrosis Factor alpha (TNF-a) reduces intestinal vitamin C uptake: a role for NF-?B mediated signaling. Am J Physiol Gastrointest Liver Physiol. 2018 Apr 06. PMID: 29631379.
      View in: PubMed
    3. Elahi A, Sabui S, Narasappa NN, Agrawal S, Lambrecht NW, Agrawal A, Said H. Biotin Deficiency Induces Th1- and Th17-Mediated Proinflammatory Responses in Human CD4+ T Lymphocytes via Activation of the mTOR Signaling Pathway. J Immunol. 2018 Apr 15; 200(8):2563-2570. PMID: 29531163.
      View in: PubMed
    4. Nabokina SM, Ramos MB, Said H. Correction: Mechanism(S) Involved in the Colon-Specific Expression of the Thiamine Pyrophosphate (Tpp) Transporter. PLoS One. 2017; 12(10):e0186550. PMID: 29020075.
      View in: PubMed
    5. Subramanian VS, Nabokina SM, Lin-Moshier Y, Marchant JS, Said H. Correction: Mitochondrial Uptake of Thiamin Pyrophosphate: Physiological and Cell Biological Aspects. PLoS One. 2017; 12(10):e0186541. PMID: 29020070.
      View in: PubMed
    6. Subramanian VS, Sabui S, Moradi H, Marchant JS, Said H. Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanisms. Biochim Biophys Acta. 2018 02; 1860(2):556-565. PMID: 29030247.
      View in: PubMed
    7. Nabokina SM, Inoue K, Subramanian VS, Valle JE, Yuasa H, Said H. Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2017 10 06; 292(40):16526. PMID: 28986434.
      View in: PubMed
    8. Anandam KY, Srinivasan P, Subramanian VS, Said H. Molecular mechanisms involved in the adaptive regulation of the colonic thiamin pyrophosphate uptake process. Am J Physiol Cell Physiol. 2017 Dec 01; 313(6):C655-C663. PMID: 28931541.
      View in: PubMed
    9. Lakhan R, Subramanian VS, Said H. Role of MicroRNA-423-5p in posttranscriptional regulation of the intestinal riboflavin transporter-3. Am J Physiol Gastrointest Liver Physiol. 2017 Dec 01; 313(6):G589-G598. PMID: 28912250.
      View in: PubMed
    10. Sabui S, Subramanian VS, Kapadia R, Said H. Adaptive regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: possible involvement of epigenetic mechanism(s). Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G448-G455. PMID: 28729247.
      View in: PubMed
    11. Subramanian VS, Sabui S, Teafatiller T, Bohl JA, Said H. Structure/functional aspects of the human riboflavin transporter-3 (SLC52A3): role of the predicted glycosylation and substrate-interacting sites. Am J Physiol Cell Physiol. 2017 Aug 01; 313(2):C228-C238. PMID: 28637675.
      View in: PubMed
    12. Lakhan R, Said H. Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C376-C384. PMID: 28052864.
      View in: PubMed
    13. Subramanian VS, Srinivasan P, Wildman AJ, Marchant JS, Said H. Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract. Am J Physiol Gastrointest Liver Physiol. 2017 Apr 01; 312(4):G340-G347. PMID: 27932501.
      View in: PubMed
    14. Subramanian VS, Constantinescu AR, Benke PJ, Said H. Mutations in SLC5A6 associated with brain, immune, bone, and intestinal dysfunction in a young child. Hum Genet. 2017 02; 136(2):253-261. PMID: 27904971.
      View in: PubMed
    15. Udhayabanu T, Subramanian VS, Teafatiller T, Gowda VK, Raghavan VS, Varalakshmi P, Said H, Ashokkumar B. SLC52A2 [p.P141T] and SLC52A3 [p.N21S] causing Brown-Vialetto-Van Laere Syndrome in an Indian patient: First genetically proven case with mutations in two riboflavin transporters. Clin Chim Acta. 2016 Nov 01; 462:210-214. PMID: 27702554.
      View in: PubMed
    16. Sassoon CS, Zhu E, Fang L, Subramanian VS, Said H. Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. Crit Care Med. 2016 Sep; 44(9):e875-81. PMID: 27065466; PMCID: PMC4987227.
      View in: PubMed, PubMed Central
    17. Sabui S, Bohl JA, Kapadia R, Cogburn K, Ghosal A, Lambrecht NW, Said H. Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 01; 311(3):G561-70. PMID: 27492331.
      View in: PubMed
    18. Moradi H, Said H. Functional thiamine deficiency in end-stage renal disease: malnutrition despite ample nutrients. Kidney Int. 2016 08; 90(2):252-254. PMID: 27418090.
      View in: PubMed
    19. Agrawal S, Agrawal A, Said H. Biotin deficiency enhances the inflammatory response of human dendritic cells. Am J Physiol Cell Physiol. 2016 Sep 01; 311(3):C386-91. PMID: 27413170.
      View in: PubMed
    20. Sabui S, Subramanian VS, Kapadia R, Said H. Structure-function characterization of the human mitochondrial thiamin pyrophosphate transporter (hMTPPT; SLC25A19): Important roles for Ile(33), Ser(34), Asp(37), His(137) and Lys(291). Biochim Biophys Acta. 2016 08; 1858(8):1883-90. PMID: 27188525; PMCID: PMC4900926 [Available on 08/01/17].
      View in: PubMed, PubMed Central
    21. Subramanian VS, Srinivasan P, Said H. Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure. Am J Physiol Cell Physiol. 2016 Jul 01; 311(1):C129-35. PMID: 27122159; PMCID: PMC4967129 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    22. Srinivasan P, Thrower EC, Gorelick FS, Said H. Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Am J Physiol Gastrointest Liver Physiol. 2016 May 15; 310(10):G874-83. PMID: 26999808; PMCID: PMC4888549 [Available on 05/15/17].
      View in: PubMed, PubMed Central
    23. Nabokina SM, Ramos MB, Said H. Mechanism(S) Involved in the Colon-Specific Expression of the Thiamine Pyrophosphate (Tpp) Transporter. PLoS One. 2016; 11(2):e0149255. PMID: 26901654; PMCID: PMC4764741.
      View in: PubMed, PubMed Central
    24. Nabokina SM, Subramanian VS, Said H. The human colonic thiamine pyrophosphate transporter (hTPPT) is a glycoprotein and N-linked glycosylation is important for its function. Biochim Biophys Acta. 2016 Apr; 1858(4):866-71. PMID: 26828122; PMCID: PMC4779673 [Available on 04/01/17].
      View in: PubMed, PubMed Central
    25. Subramanian VS, Lambrecht N, Lytle C, Said H. Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15; 310(4):G285-93. PMID: 26660539; PMCID: PMC4754740 [Available on 02/15/17].
      View in: PubMed, PubMed Central
    26. Srinivasan P, Thrower EC, Loganathan G, Balamurugan AN, Subramanian VS, Gorelick FS, Said H. Chronic Nicotine Exposure In Vivo and In Vitro Inhibits Vitamin B1 (Thiamin) Uptake by Pancreatic Acinar Cells. PLoS One. 2015; 10(12):e0143575. PMID: 26633299; PMCID: PMC4669105.
      View in: PubMed, PubMed Central
    27. Manimaran P, Subramanian VS, Karthi S, Gandhimathi K, Varalakshmi P, Ganesh R, Rathinavel A, Said H, Ashokkumar B. Novel nonsense mutation (p.Ile411Metfs*12) in the SLC19A2 gene causing Thiamine Responsive Megaloblastic Anemia in an Indian patient. Clin Chim Acta. 2016 Jan 15; 452:44-9. PMID: 26549656.
      View in: PubMed
    28. Srinivasan P, Nabokina S, Said H. Chronic alcohol exposure affects pancreatic acinar mitochondrial thiamin pyrophosphate uptake: studies with mouse 266-6 cell line and primary cells. Am J Physiol Gastrointest Liver Physiol. 2015 Nov 01; 309(9):G750-8. PMID: 26316591; PMCID: PMC4628969 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    29. Subramanian VS, Ghosal A, Kapadia R, Nabokina SM, Said H. Molecular Mechanisms Mediating the Adaptive Regulation of Intestinal Riboflavin Uptake Process. PLoS One. 2015; 10(6):e0131698. PMID: 26121134; PMCID: PMC4484800.
      View in: PubMed, PubMed Central
    30. Ghosal A, Jellbauer S, Kapadia R, Raffatellu M, Said H. Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15; 309(2):G123-31. PMID: 25999427; PMCID: PMC4504957.
      View in: PubMed, PubMed Central
    31. Subramanian VS, Kapadia R, Ghosal A, Said H. Identification of residues/sequences in the human riboflavin transporter-2 that is important for function and cell biology. Nutr Metab (Lond). 2015; 12:13. PMID: 25798182; PMCID: PMC4367879.
      View in: PubMed, PubMed Central
    32. Nabokina SM, Ramos MB, Valle JE, Said H. Regulation of basal promoter activity of the human thiamine pyrophosphate transporter SLC44A4 in human intestinal epithelial cells. Am J Physiol Cell Physiol. 2015 May 01; 308(9):C750-7. PMID: 25715703; PMCID: PMC4420793.
      View in: PubMed, PubMed Central
    33. Said H. Water-soluble vitamins. World Rev Nutr Diet. 2015; 111:30-7. PMID: 25418386.
      View in: PubMed
    34. Ghosal A, Sabui S, Said H. Identification and characterization of the minimal 5'-regulatory region of the human riboflavin transporter-3 (SLC52A3) in intestinal epithelial cells. Am J Physiol Cell Physiol. 2015 Jan 15; 308(2):C189-96. PMID: 25394472; PMCID: PMC4297772.
      View in: PubMed, PubMed Central
    35. Sabui S, Ghosal A, Said H. Identification and characterization of 5'-flanking region of the human riboflavin transporter 1 gene (SLC52A1). Gene. 2014 Dec 10; 553(1):49-56. PMID: 25284511; PMCID: PMC4254174.
      View in: PubMed, PubMed Central
    36. Srinivasan P, Kapadia R, Biswas A, Said H. Chronic alcohol exposure inhibits biotin uptake by pancreatic acinar cells: possible involvement of epigenetic mechanisms. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 01; 307(9):G941-9. PMID: 25214397; PMCID: PMC4250263.
      View in: PubMed, PubMed Central
    37. Ghosal A, Sekar TV, Said H. Biotin uptake by mouse and human pancreatic beta cells/islets: a regulated, lipopolysaccharide-sensitive carrier-mediated process. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 01; 307(3):G365-73. PMID: 24904078; PMCID: PMC4121639.
      View in: PubMed, PubMed Central
    38. Srinivasan P, Subramanian VS, Said H. Mechanisms involved in the inhibitory effect of chronic alcohol exposure on pancreatic acinar thiamin uptake. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 01; 306(7):G631-9. PMID: 24525018; PMCID: PMC3962591.
      View in: PubMed, PubMed Central
    39. Nabokina SM, Inoue K, Subramanian VS, Valle JE, Yuasa H, Said H. Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2014 Feb 14; 289(7):4405-16. PMID: 24379411; PMCID: PMC3924303.
      View in: PubMed, PubMed Central
    40. Subramanian VS, Nabokina SM, Said H. Association of TM4SF4 with the human thiamine transporter-2 in intestinal epithelial cells. Dig Dis Sci. 2014 Mar; 59(3):583-90. PMID: 24282057; PMCID: PMC3943980.
      View in: PubMed, PubMed Central
    41. Srinivasan P, Subramanian VS, Said H. Effect of the cigarette smoke component, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), on physiological and molecular parameters of thiamin uptake by pancreatic acinar cells. PLoS One. 2013; 8(11):e78853. PMID: 24244374; PMCID: PMC3820693.
      View in: PubMed, PubMed Central
    42. Ghosal A, Chatterjee NS, Chou T, Said H. Enterotoxigenic Escherichia coli infection and intestinal thiamin uptake: studies with intestinal epithelial Caco-2 monolayers. Am J Physiol Cell Physiol. 2013 Dec 01; 305(11):C1185-91. PMID: 24133060; PMCID: PMC3882383.
      View in: PubMed, PubMed Central
    43. Subramanian VS, Nabokina SM, Lin-Moshier Y, Marchant JS, Said H. Mitochondrial uptake of thiamin pyrophosphate: physiological and cell biological aspects. PLoS One. 2013; 8(8):e73503. PMID: 24023687; PMCID: PMC3758298.
      View in: PubMed, PubMed Central
    44. Nabokina SM, Subramanian VS, Valle JE, Said H. Adaptive regulation of human intestinal thiamine uptake by extracellular substrate level: a role for THTR-2 transcriptional regulation. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G593-9. PMID: 23989004; PMCID: PMC3798731.
      View in: PubMed, PubMed Central
    45. Said H. Recent advances in transport of water-soluble vitamins in organs of the digestive system: a focus on the colon and the pancreas. Am J Physiol Gastrointest Liver Physiol. 2013 Nov; 305(9):G601-10. PMID: 23989008; PMCID: PMC3840235.
      View in: PubMed, PubMed Central
    46. Nabokina SM, Valle JE, Said H. Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: a role for NF-Y in regulating basal transcription. Gene. 2013 Oct 10; 528(2):248-55. PMID: 23872534; PMCID: PMC3764993.
      View in: PubMed, PubMed Central
    47. Subramanian VS, Subramanya SB, Ghosal A, Said H. Chronic alcohol feeding inhibits physiological and molecular parameters of intestinal and renal riboflavin transport. Am J Physiol Cell Physiol. 2013 Sep; 305(5):C539-46. PMID: 23804199; PMCID: PMC3761153.
      View in: PubMed, PubMed Central
    48. Kumar JS, Subramanian VS, Kapadia R, Kashyap ML, Said H. Mammalian colonocytes possess a carrier-mediated mechanism for uptake of vitamin B3 (niacin): studies utilizing human and mouse colonic preparations. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 01; 305(3):G207-13. PMID: 23744738; PMCID: PMC3742858.
      View in: PubMed, PubMed Central
    49. Augagneur Y, Jaubert L, Schiavoni M, Pachikara N, Garg A, Usmani-Brown S, Wesolowski D, Zeller S, Ghosal A, Cornillot E, Said H, Kumar P, Altman S, Ben Mamoun C. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum. J Biol Chem. 2013 Jul 12; 288(28):20558-67. PMID: 23729665; PMCID: PMC3711320.
      View in: PubMed, PubMed Central
    50. Al-Sadi R, Guo S, Ye D, Dokladny K, Alhmoud T, Ereifej L, Said H, Ma TY. Mechanism of IL-1ß modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation. J Immunol. 2013 Jun 15; 190(12):6596-606. PMID: 23656735; PMCID: PMC3677168.
      View in: PubMed, PubMed Central
    51. Moradi H, Vaziri ND, Kashyap ML, Said H, Kalantar-Zadeh K. Role of HDL dysfunction in end-stage renal disease: a double-edged sword. J Ren Nutr. 2013 May; 23(3):203-6. PMID: 23611547.
      View in: PubMed
    52. Subramanian VS, Nabokina SM, Patton JR, Marchant JS, Moradi H, Said H. Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15; 304(12):G1079-86. PMID: 23599041; PMCID: PMC3680717.
      View in: PubMed, PubMed Central
    53. Biswas A, Elmatari D, Rothman J, LaMunyon CW, Said H. Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2. PLoS One. 2013; 8(3):e58190. PMID: 23483992; PMCID: PMC3590142.
      View in: PubMed, PubMed Central
    54. Subramanian VS, Ghosal A, Subramanya SB, Lytle C, Said H. Differentiation-dependent regulation of intestinal vitamin B(2) uptake: studies utilizing human-derived intestinal epithelial Caco-2 cells and native rat intestine. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 15; 304(8):G741-8. PMID: 23413253; PMCID: PMC3625875.
      View in: PubMed, PubMed Central
    55. Moradi H, Said H, Vaziri ND. Post-transcriptional nature of uremia-induced downregulation of hepatic apolipoprotein A-I production. Transl Res. 2013 Jun; 161(6):477-85. PMID: 23219399; PMCID: PMC3609941.
      View in: PubMed, PubMed Central
    56. Guo S, Al-Sadi R, Said H, Ma TY. Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14. Am J Pathol. 2013 Feb; 182(2):375-87. PMID: 23201091; PMCID: PMC3562736.
      View in: PubMed, PubMed Central
    57. Ghosal A, Lambrecht N, Subramanya SB, Kapadia R, Said H. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 01; 304(1):G64-71. PMID: 23104561; PMCID: PMC3543636.
      View in: PubMed, PubMed Central
    58. Subramanian VS, Subramanya SB, Ghosal A, Marchant JS, Harada A, Said H. Modulation of function of sodium-dependent vitamin C transporter 1 (SVCT1) by Rab8a in intestinal epithelial cells: studies utilizing Caco-2 cells and Rab8a knockout mice. Dig Dis Sci. 2013 Mar; 58(3):641-9. PMID: 23014846; PMCID: PMC3547156.
      View in: PubMed, PubMed Central
    59. Ghosal A, Said H. Mechanism and regulation of vitamin B2 (riboflavin) uptake by mouse and human pancreatic ß-cells/islets: physiological and molecular aspects. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 01; 303(9):G1052-8. PMID: 22917629; PMCID: PMC3517668.
      View in: PubMed, PubMed Central
    60. Nabokina SM, Said H. A high-affinity and specific carrier-mediated mechanism for uptake of thiamine pyrophosphate by human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 01; 303(3):G389-95. PMID: 22628036; PMCID: PMC3423106.
      View in: PubMed, PubMed Central
    61. Nabokina SM, Subramanian VS, Said H. Effect of clinical mutations on functionality of the human riboflavin transporter-2 (hRFT-2). Mol Genet Metab. 2012 Apr; 105(4):652-7. PMID: 22273710; PMCID: PMC3309148.
      View in: PubMed, PubMed Central
    62. Said H. Biotin: biochemical, physiological and clinical aspects. Subcell Biochem. 2012; 56:1-19. PMID: 22116691.
      View in: PubMed
    63. Subramanian VS, Subramanya SB, Said H. Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 01; 302(5):G572-8. PMID: 22194418; PMCID: PMC3311432.
      View in: PubMed, PubMed Central
    64. Ghosal A, Said H. Cys(294) is essential for the function of the human sodium-dependent multivitamin transporter. Biochim Biophys Acta. 2012 Jan; 1818(1):97-102. PMID: 22015582; PMCID: PMC3230660.
      View in: PubMed, PubMed Central
    65. Biswas A, Senthilkumar SR, Said H. Effect of chronic alcohol exposure on folate uptake by liver mitochondria. Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C203-9. PMID: 21956163; PMCID: PMC3328914.
      View in: PubMed, PubMed Central
    66. Subramanya SB, Subramanian VS, Sekar VT, Said H. Thiamin uptake by pancreatic acinar cells: effect of chronic alcohol feeding/exposure. Am J Physiol Gastrointest Liver Physiol. 2011 Nov; 301(5):G896-904. PMID: 21868632; PMCID: PMC3220324.
      View in: PubMed, PubMed Central
    67. Subramanian VS, Subramanya SB, Rapp L, Marchant JS, Ma TY, Said H. Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. Biochim Biophys Acta. 2011 Dec; 1808(12):3016-21. PMID: 21854757; PMCID: PMC3196270.
      View in: PubMed, PubMed Central
    68. Nabokina SM, Senthilkumar SR, Said H. Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. Am J Physiol Gastrointest Liver Physiol. 2011 Nov; 301(5):G808-13. PMID: 21836059; PMCID: PMC3220328.
      View in: PubMed, PubMed Central
    69. Said H. Intestinal absorption of water-soluble vitamins in health and disease. Biochem J. 2011 Aug 01; 437(3):357-72. PMID: 21749321; PMCID: PMC4049159.
      View in: PubMed, PubMed Central
    70. Ghosal A, Subramanian VS, Said H. Role of the putative N-glycosylation and PKC-phosphorylation sites of the human sodium-dependent multivitamin transporter (hSMVT) in function and regulation. Biochim Biophys Acta. 2011 Aug; 1808(8):2073-80. PMID: 21570947; PMCID: PMC3130002.
      View in: PubMed, PubMed Central
    71. Subramanian VS, Rapp L, Marchant JS, Said H. Role of cysteine residues in cell surface expression of the human riboflavin transporter-2 (hRFT2) in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011 Jul; 301(1):G100-9. PMID: 21512156; PMCID: PMC3129935.
      View in: PubMed, PubMed Central
    72. Al-Sadi R, Ye D, Said H, Ma TY. Cellular and molecular mechanism of interleukin-1ß modulation of Caco-2 intestinal epithelial tight junction barrier. J Cell Mol Med. 2011 Apr; 15(4):970-82. PMID: 20406328; PMCID: PMC3922681.
      View in: PubMed, PubMed Central
    73. Subramanian VS, Subramanya SB, Said H. Chronic alcohol exposure negatively impacts the physiological and molecular parameters of the renal biotin reabsorption process. Am J Physiol Renal Physiol. 2011 Mar; 300(3):F611-7. PMID: 21209005; PMCID: PMC3064131.
      View in: PubMed, PubMed Central
    74. Nabokina SM, Subramanian VS, Said H. Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G561-7. PMID: 21183659; PMCID: PMC3074986.
      View in: PubMed, PubMed Central
    75. Bukhari FJ, Moradi H, Gollapudi P, Ju Kim H, Vaziri ND, Said H. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Nephrol Dial Transplant. 2011 Jul; 26(7):2137-44. PMID: 21149507; PMCID: PMC3164444.
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    76. Subramanya SB, Subramanian VS, Kumar JS, Hoiness R, Said H. Inhibition of intestinal biotin absorption by chronic alcohol feeding: cellular and molecular mechanisms. Am J Physiol Gastrointest Liver Physiol. 2011 Mar; 300(3):G494-501. PMID: 21148397; PMCID: PMC3064116.
      View in: PubMed, PubMed Central
    77. Al-Sadi R, Ye D, Said H, Ma TY. IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway. Am J Pathol. 2010 Nov; 177(5):2310-22. PMID: 21048223; PMCID: PMC2966790.
      View in: PubMed, PubMed Central
    78. Ghosal A, Said H. Structure-function activity of the human sodium-dependent multivitamin transporter: role of His¹¹⁵ and His²54. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C97-104. PMID: 20962270; PMCID: PMC3023183.
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    79. Subramanya SB, Subramanian VS, Said H. Chronic alcohol consumption and intestinal thiamin absorption: effects on physiological and molecular parameters of the uptake process. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G23-31. PMID: 20448146; PMCID: PMC2904112.
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    80. Austin MU, Liau WS, Balamurugan K, Ashokkumar B, Said H, LaMunyon CW. Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans. BMC Dev Biol. 2010 May 04; 10:46. PMID: 20441590; PMCID: PMC2874772.
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    81. Subramanian VS, Subramanya SB, Tsukamoto H, Said H. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. PMID: 20427470; PMCID: PMC2904160.
      View in: PubMed, PubMed Central
    82. Said H, Mee L, Sekar VT, Ashokkumar B, Pandol SJ. Mechanism and regulation of folate uptake by pancreatic acinar cells: effect of chronic alcohol consumption. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G985-93. PMID: 20360131; PMCID: PMC3774332.
      View in: PubMed, PubMed Central
    83. Subramanian VS, Marchant JS, Said H. Molecular determinants dictating cell surface expression of the human sodium-dependent vitamin C transporter-2 in human liver cells. Am J Physiol Gastrointest Liver Physiol. 2010 Feb; 298(2):G267-74. PMID: 19926816; PMCID: PMC2822508.
      View in: PubMed, PubMed Central
    84. Reidling JC, Lambrecht N, Kassir M, Said H. Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Gastroenterology. 2010 May; 138(5):1802-9. PMID: 19879271; PMCID: PMC4916904.
      View in: PubMed, PubMed Central
    85. Ashokkumar B, Kumar JS, Hecht GA, Said H. Enteropathogenic Escherichia coli inhibits intestinal vitamin B1 (thiamin) uptake: studies with human-derived intestinal epithelial Caco-2 cells. Am J Physiol Gastrointest Liver Physiol. 2009 Oct; 297(4):G825-33. PMID: 19628653; PMCID: PMC2763801.
      View in: PubMed, PubMed Central
    86. Ashokkumar B, Nabokina SM, Ma TY, Said H. Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. Am J Physiol Gastrointest Liver Physiol. 2009 Sep; 297(3):G480-7. PMID: 19571232; PMCID: PMC2739825.
      View in: PubMed, PubMed Central
    87. Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said H. Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations. Am J Physiol Gastrointest Liver Physiol. 2009 Jul; 297(1):G197-206. PMID: 19423748; PMCID: PMC2711754.
      View in: PubMed, PubMed Central
    88. Subramanian VS, Marchant JS, Boulware MJ, Ma TY, Said H. Membrane targeting and intracellular trafficking of the human sodium-dependent multivitamin transporter in polarized epithelial cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C663-71. PMID: 19211916; PMCID: PMC2670647.
      View in: PubMed, PubMed Central
    89. Mock DM, Said H. Introduction to "Advances in understanding of the biological role of biotin at the clinical, biochemical, and molecular level". J Nutr. 2009 Jan; 139(1):152-3. PMID: 19056638.
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    90. Said H. Cell and molecular aspects of human intestinal biotin absorption. J Nutr. 2009 Jan; 139(1):158-62. PMID: 19056639; PMCID: PMC2646215.
      View in: PubMed, PubMed Central
    91. Reidling JC, Subramanian VS, Dahhan T, Sadat M, Said H. Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 Dec; 295(6):G1217-27. PMID: 18845575; PMCID: PMC2604802.
      View in: PubMed, PubMed Central
    92. Subramanian VS, Reidling JC, Said H. Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C828-35. PMID: 18650265; PMCID: PMC2544450.
      View in: PubMed, PubMed Central
    93. Subramanian VS, Marchant JS, Reidling JC, Said H. N-Glycosylation is required for Na+-dependent vitamin C transporter functionality. Biochem Biophys Res Commun. 2008 Sep 12; 374(1):123-7. PMID: 18619416; PMCID: PMC2528843.
      View in: PubMed, PubMed Central
    94. Said ZM, Subramanian VS, Vaziri ND, Said H. Pyridoxine uptake by colonocytes: a specific and regulated carrier-mediated process. Am J Physiol Cell Physiol. 2008 May; 294(5):C1192-7. PMID: 18353902.
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    95. Subramanian VS, Marchant JS, Said H. Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C233-40. PMID: 18003745.
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    96. Said H, Nabokina SM, Balamurugan K, Mohammed ZM, Urbina C, Kashyap ML. Mechanism of nicotinic acid transport in human liver cells: experiments with HepG2 cells and primary hepatocytes. Am J Physiol Cell Physiol. 2007 Dec; 293(6):C1773-8. PMID: 17928533.
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    97. Subramanian VS, Marchant JS, Ye D, Ma TY, Said H. Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells. Am J Physiol Cell Physiol. 2007 Nov; 293(5):C1717-26. PMID: 17855770.
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    98. Ashokkumar B, Mohammed ZM, Vaziri ND, Said H. Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. Am J Clin Nutr. 2007 Jul; 86(1):159-66. PMID: 17616776.
      View in: PubMed
    99. Subramanian VS, Marchant JS, Said H. Targeting and intracellular trafficking of clinically relevant hTHTR1 mutations in human cell lines. Clin Sci (Lond). 2007 Jul; 113(2):93-102. PMID: 17331069.
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    100. Balamurugan K, Ashokkumar B, Moussaif M, Sze JY, Said H. Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C670-81. PMID: 17475669.
      View in: PubMed
    101. Subramanian VS, Mohammed ZM, Molina A, Marchant JS, Vaziri ND, Said H. Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation. J Physiol. 2007 Jul 01; 582(Pt 1):73-85. PMID: 17463047; PMCID: PMC2075275.
      View in: PubMed, PubMed Central
    102. Reidling JC, Said H. Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1305-12. PMID: 17135299.
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    103. Reidling JC, Nabokina SM, Said H. Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G275-81. PMID: 16959947.
      View in: PubMed
    104. Subramanian VS, Marchant JS, Said H. Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C851-9. PMID: 16790503.
      View in: PubMed
    105. Ashokkumar B, Vaziri ND, Said H. Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F796-805. PMID: 16705148.
      View in: PubMed
    106. Said H, Mohammed ZM. Intestinal absorption of water-soluble vitamins: an update. Curr Opin Gastroenterol. 2006 Mar; 22(2):140-6. PMID: 16462170.
      View in: PubMed
    107. Balamurugan K, Said H. Role of reduced folate carrier in intestinal folate uptake. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C189-93. PMID: 16495369.
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    108. Reidling JC, Nabokina SM, Balamurugan K, Said H. Developmental maturation of intestinal and renal thiamin uptake: studies in wild-type and transgenic mice carrying human THTR-1 and 2 promoters. J Cell Physiol. 2006 Feb; 206(2):371-7. PMID: 16206251.
      View in: PubMed
    109. Schrader S, Kneuer C, Said H, Honscha W. Alternative transcripts of rat slc19a1: defective sorting and inefficient expression of alternative splicing products--an addendum. DNA Seq. 2006 Feb; 17(1):83-6. PMID: 16753822.
      View in: PubMed
    110. Subramanian VS, Marchant JS, Said H. Targeting and trafficking of the human thiamine transporter-2 in epithelial cells. J Biol Chem. 2006 Feb 24; 281(8):5233-45. PMID: 16371350.
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    111. Nabokina SM, Reidling JC, Said H. Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms. J Biol Chem. 2005 Sep 23; 280(38):32676-82. PMID: 16055442.
      View in: PubMed
    112. Said H, Wang S, Ma TY. Mechanism of riboflavin uptake by cultured human retinal pigment epithelial ARPE-19 cells: possible regulation by an intracellular Ca2+-calmodulin-mediated pathway. J Physiol. 2005 Jul 15; 566(Pt 2):369-77. PMID: 15878949; PMCID: PMC1464759.
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    113. Ma TY, Boivin MA, Ye D, Pedram A, Said H. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol. 2005 Mar; 288(3):G422-30. PMID: 15701621.
      View in: PubMed
    114. Nabokina SM, Kashyap ML, Said H. Mechanism and regulation of human intestinal niacin uptake. Am J Physiol Cell Physiol. 2005 Jul; 289(1):C97-103. PMID: 15728713.
      View in: PubMed
    115. Reidling JC, Said H. Adaptive regulation of intestinal thiamin uptake: molecular mechanism using wild-type and transgenic mice carrying hTHTR-1 and -2 promoters. Am J Physiol Gastrointest Liver Physiol. 2005 Jun; 288(6):G1127-34. PMID: 15705657.
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    116. Balamurugan K, Vaziri ND, Said H. Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects. Am J Physiol Renal Physiol. 2005 Apr; 288(4):F823-31. PMID: 15561972.
      View in: PubMed
    117. Nabokina SM, Said H. Characterization of the 5'-regulatory region of the human thiamin transporter SLC19A3: in vitro and in vivo studies. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G822-9. PMID: 15217784.
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    118. Subramanian VS, Marchant JS, Boulware MJ, Said H. A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia. J Biol Chem. 2004 Jun 25; 279(26):27719-28. PMID: 15084584.
      View in: PubMed
    119. Nabokina SM, Ma TY, Said H. Mechanism and regulation of folate uptake by human pancreatic epithelial MIA PaCa-2 cells. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C142-8. PMID: 14998787.
      View in: PubMed
    120. Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, Said H. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar; 286(3):G367-76. PMID: 14766535.
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    121. Crisp SE, Griffin JB, White BR, Toombs CF, Camporeale G, Said H, Zempleni J. Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells. Eur J Nutr. 2004 Feb; 43(1):23-31. PMID: 14991266.
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    122. Said H. Recent advances in carrier-mediated intestinal absorption of water-soluble vitamins. Annu Rev Physiol. 2004; 66:419-46. PMID: 14977409.
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    123. Boulware MJ, Subramanian VS, Said H, Marchant JS. Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function. Biochem J. 2003 Nov 15; 376(Pt 1):43-8. PMID: 14602044; PMCID: PMC1223768.
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    124. Said H, Balamurugan K, Subramanian VS, Marchant JS. Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Am J Physiol Gastrointest Liver Physiol. 2004 Mar; 286(3):G491-8. PMID: 14615284.
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    125. Reidling JC, Said H. In vitro and in vivo characterization of the minimal promoter region of the human thiamin transporter SLC19A2. Am J Physiol Cell Physiol. 2003 Sep; 285(3):C633-41. PMID: 12900388.
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    126. Subramanian VS, Chatterjee N, Said H. Folate uptake in the human intestine: promoter activity and effect of folate deficiency. J Cell Physiol. 2003 Aug; 196(2):403-8. PMID: 12811835.
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    127. Said H, Ortiz A, Ma TY. A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathway. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1219-25. PMID: 12867360.
      View in: PubMed
    128. Balamurugan K, Said H. Ontogenic regulation of folate transport across rat jejunal brush-border membrane. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G1068-73. PMID: 12842826.
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    129. Nabokina SM, Subramanian VS, Said H. Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat. Am J Physiol Renal Physiol. 2003 Apr; 284(4):F737-42. PMID: 12620923.
      View in: PubMed
    130. Balamurugan K, Ortiz A, Said H. Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system. Am J Physiol Gastrointest Liver Physiol. 2003 Jul; 285(1):G73-7. PMID: 12646417.
      View in: PubMed
    131. Dudeja PK, Tyagi S, Gill R, Said H. Evidence for a carrier-mediated mechanism for thiamine transport to human jejunal basolateral membrane vesicles. Dig Dis Sci. 2003 Jan; 48(1):109-15. PMID: 12645798.
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    132. Said H, Reidling JC, Ortiz A. Cellular and molecular aspects of thiamin uptake by human liver cells: studies with cultured HepG2 cells. Biochim Biophys Acta. 2002 Dec 23; 1567(1-2):106-12. PMID: 12488043.
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    133. Subramanian VS, Marchant JS, Parker I, Said H. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J Biol Chem. 2003 Feb 07; 278(6):3976-84. PMID: 12454006.
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    134. Balamurugan K, Said H. Functional role of specific amino acid residues in human thiamine transporter SLC19A2: mutational analysis. Am J Physiol Gastrointest Liver Physiol. 2002 Jul; 283(1):G37-43. PMID: 12065289.
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    135. Marchant JS, Subramanian VS, Parker I, Said H. Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. J Biol Chem. 2002 Sep 06; 277(36):33325-33. PMID: 12087110.
      View in: PubMed
    136. Reidling JC, Subramanian VS, Dudeja PK, Said H. Expression and promoter analysis of SLC19A2 in the human intestine. Biochim Biophys Acta. 2002 Apr 12; 1561(2):180-7. PMID: 11997118.
      View in: PubMed
    137. Dey S, Subramanian VS, Chatterjee NS, Rubin SA, Said H. Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT. Biochim Biophys Acta. 2002 Mar 19; 1574(2):187-92. PMID: 11955628.
      View in: PubMed
    138. Said H, Ortiz A, Vaziri ND. Mechanism and regulation of vitamin B(6) uptake by renal tubular epithelia: studies with cultured OK cells. Am J Physiol Renal Physiol. 2002 Mar; 282(3):F465-71. PMID: 11832427.
      View in: PubMed
    139. Said H. Biotin: the forgotten vitamin. Am J Clin Nutr. 2002 Feb; 75(2):179-80. PMID: 11815306.
      View in: PubMed
    140. Said H, Ortiz A, Subramanian VS, Neufeld EJ, Moyer MP, Dudeja PK. Mechanism of thiamine uptake by human colonocytes: studies with cultured colonic epithelial cell line NCM460. Am J Physiol Gastrointest Liver Physiol. 2001 Jul; 281(1):G144-50. PMID: 11408266.
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    141. Said H, Chatterjee N, Haq RU, Subramanian VS, Ortiz A, Matherly LH, Sirotnak FM, Halsted C, Rubin SA. Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1889-95. PMID: 11078704.
      View in: PubMed
    142. Said H, Ortiz A, Moyer MP, Yanagawa N. Riboflavin uptake by human-derived colonic epithelial NCM460 cells. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C270-6. PMID: 10666022.
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    143. Said H, Ortiz A, Ma TY, McCloud E. Riboflavin uptake by the human-derived liver cells Hep G2: mechanism and regulation. J Cell Physiol. 1998 Sep; 176(3):588-94. PMID: 9699511.
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