Matthew Inlay

Title(s)Assistant Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address2010 Gross Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-8226
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying the precursor to hematopoietic stem cells in the mouse embryo and improving its engraftment upon transplantation
    NIH R21CA224022Jan 10, 2019 - Dec 31, 2020
    Role: Principal Investigator
    Distinguishing the roles of microglia and infiltrating monocytes in beta-amyloid plaque formation and neuroinflammation in Alzheimer's Disease in mouse models and human patient samples
    NIH R03NS099969Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Identifying precursors to hematopoietic stem cells and where they arise in the mouse embryo
    NIH R56HL133656Sep 15, 2016 - Aug 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Graft conditioning with fluticasone propionate reduces graft-versus-host disease upon allogeneic hematopoietic cell transplantation in mice. EMBO Mol Med. 2023 09 11; 15(9):e17748. Varady ES, Ayala LA, Nguyen PU, Scarfone VM, Karimzadeh A, Zhou C, Chen X, Greilach SA, Walsh CM, Inlay MA. PMID: 37538042; PMCID: PMC10493574.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Single-tube collection and nucleic acid analysis of clinical samples for SARS-CoV-2 saliva testing. Sci Rep. 2022 03 10; 12(1):3951. Cole KH, Bouin A, Ruiz C, Semler BL, Inlay MA, Lupták A. PMID: 35273232; PMCID: PMC8913774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. MAC2 is a long-lasting marker of peripheral cell infiltrates into the mouse CNS after bone marrow transplantation and coronavirus infection. Glia. 2022 05; 70(5):875-891. Hohsfield LA, Tsourmas KI, Ghorbanian Y, Syage AR, Jin Kim S, Cheng Y, Furman S, Inlay MA, Lane TE, Green KN. PMID: 35025109; PMCID: PMC8930563.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    4. Absence of CD11a Expression Identifies Embryonic Hematopoietic Stem Cell Precursors via Competitive Neonatal Transplantation Assay. Front Cell Dev Biol. 2021; 9:734176. Karimzadeh A, Varady ES, Scarfone VM, Chao C, Grathwohl K, Nguyen PU, Ghorbanian Y, Weissman IL, Serwold T, Inlay MA. PMID: 34513848; PMCID: PMC8425522.
      View in: PubMed   Mentions:
    5. Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave. Elife. 2021 08 23; 10. Hohsfield LA, Najafi AR, Ghorbanian Y, Soni N, Crapser J, Figueroa Velez DX, Jiang S, Royer SE, Kim SJ, Henningfield CM, Anderson A, Gandhi SP, Mortazavi A, Inlay MA, Green KN. PMID: 34423781; PMCID: PMC8425950.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    6. Author Correction: Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nat Commun. 2019 Dec 04; 10(1):5624. Pavel-Dinu M, Wiebking V, Dejene BT, Srifa W, Mantri S, Nicolas CE, Lee C, Bao G, Kildebeck EJ, Punjya N, Sindhu C, Inlay MA, Saxena N, DeRavin SS, Malech H, Roncarolo MG, Weinberg KI, Porteus MH. PMID: 31796738; PMCID: PMC6890644.
      View in: PubMed   Mentions: 5     Fields:    
    7. Author Correction: Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nat Commun. 2019 Apr 26; 10(1):2021. Pavel-Dinu M, Wiebking V, Dejene BT, Srifa W, Mantri S, Nicolas CE, Lee C, Bao G, Kildebeck EJ, Punjya N, Sindhu C, Inlay MA, Saxena N, DeRavin SS, Malech H, Roncarolo MG, Weinberg KI, Porteus MH. PMID: 31028274; PMCID: PMC6486578.
      View in: PubMed   Mentions: 1     Fields:    
    8. Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nat Commun. 2019 04 09; 10(1):1634. Pavel-Dinu M, Wiebking V, Dejene BT, Srifa W, Mantri S, Nicolas CE, Lee C, Bao G, Kildebeck EJ, Punjya N, Sindhu C, Inlay MA, Saxena N, DeRavin SS, Malech H, Roncarolo MG, Weinberg KI, Porteus MH. PMID: 30967552; PMCID: PMC6456568.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    9. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports. 2019 03 05; 12(3):451-460. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. PMID: 30745035; PMCID: PMC6409424.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    10. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. 2019 05; 67(5):844-856. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. PMID: 30588668; PMCID: PMC7375697.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    11. The CD11a and Endothelial Protein C Receptor Marker Combination Simplifies and Improves the Purification of Mouse Hematopoietic Stem Cells. Stem Cells Transl Med. 2018 06; 7(6):468-476. Karimzadeh A, Scarfone VM, Varady E, Chao C, Grathwohl K, Fathman JW, Fruman DA, Serwold T, Inlay MA. PMID: 29543389; PMCID: PMC5980368.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage. Cell Rep. 2016 11 22; 17(9):2286-2298. Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA. PMID: 27880904; PMCID: PMC6940422.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    13. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1316-25. Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. PMID: 26884167; PMCID: PMC4780638.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    14. CD201 and CD27 identify hematopoietic stem and progenitor cells across multiple murine strains independently of Kit and Sca-1. Exp Hematol. 2015 Jul; 43(7):578-85. Vazquez SE, Inlay MA, Serwold T. PMID: 25892186; PMCID: PMC4480781.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    15. 4-Hydroxytamoxifen probes for light-dependent spatiotemporal control of Cre-ER mediated reporter gene expression. Mol Biosyst. 2015 Mar; 11(3):783-90. Faal T, Wong PT, Tang S, Coulter A, Chen Y, Tu CH, Baker JR, Choi SK, Inlay MA. PMID: 25502239.
      View in: PubMed   Mentions: 14     Fields:    
    16. Upregulation of CD11A on hematopoietic stem cells denotes the loss of long-term reconstitution potential. Stem Cell Reports. 2014 Nov 11; 3(5):707-15. Fathman JW, Fernhoff NB, Seita J, Chao C, Scarfone VM, Weissman IL, Inlay MA. PMID: 25418718; PMCID: PMC4235136.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. Cell Stem Cell. 2014 Jul 03; 15(1):37-50. Beerman I, Seita J, Inlay MA, Weissman IL, Rossi DJ. PMID: 24813857; PMCID: PMC4082747.
      View in: PubMed   Mentions: 225     Fields:    Translation:AnimalsCells
    18. Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development. Stem Cell Reports. 2014 Apr 08; 2(4):457-72. Inlay MA, Serwold T, Mosley A, Fathman JW, Dimov IK, Seita J, Weissman IL. PMID: 24749071; PMCID: PMC3986503.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    19. Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification. Chem Commun (Camb). 2013 May 28; 49(43):4971-3. Inlay MA, Choe V, Bharathi S, Fernhoff NB, Baker JR, Weissman IL, Choi SK. PMID: 23612712; PMCID: PMC3926663.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    20. Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11103-8. Tseng D, Volkmer JP, Willingham SB, Contreras-Trujillo H, Fathman JW, Fernhoff NB, Seita J, Inlay MA, Weiskopf K, Miyanishi M, Weissman IL. PMID: 23690610; PMCID: PMC3703977.
      View in: PubMed   Mentions: 311     Fields:    Translation:HumansAnimalsCells
    21. Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3405-10. Ardehali R, Ali SR, Inlay MA, Abilez OJ, Chen MQ, Blauwkamp TA, Yazawa M, Gong Y, Nusse R, Drukker M, Weissman IL. PMID: 23391730; PMCID: PMC3587189.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    22. Gene Expression Commons: an open platform for absolute gene expression profiling. PLoS One. 2012; 7(7):e40321. Seita J, Sahoo D, Rossi DJ, Bhattacharya D, Serwold T, Inlay MA, Ehrlich LI, Fathman JW, Dill DL, Weissman IL. PMID: 22815738; PMCID: PMC3399844.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimals
    23. Identification of the earliest natural killer cell-committed progenitor in murine bone marrow. Blood. 2011 Nov 17; 118(20):5439-47. Fathman JW, Bhattacharya D, Inlay MA, Seita J, Karsunky H, Weissman IL. PMID: 21931117; PMCID: PMC3217348.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    24. Enhanced survival of pluripotent stem cells under stressful conditions. Cell Cycle. 2011 Aug 15; 10(16):2610-1. Ardehali R, Ali SR, Inlay MA, Mosley AR, Weissman IL. PMID: 21791974.
      View in: PubMed   Mentions:    Fields:    
    25. An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol. 2011 Aug 14; 29(9):829-34. Tang C, Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, Inlay MA, Ardehali R, Chavez SL, Pera RR, Behr B, Wu JC, Weissman IL, Drukker M. PMID: 21841799; PMCID: PMC3537836.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    26. Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3282-7. Ardehali R, Inlay MA, Ali SR, Tang C, Drukker M, Weissman IL. PMID: 21300885; PMCID: PMC3044421.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    27. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature. 2010 Sep 16; 467(7313):338-42. Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP. PMID: 20720541; PMCID: PMC2956609.
      View in: PubMed   Mentions: 338     Fields:    Translation:AnimalsCells
    28. MiDReG: a method of mining developmentally regulated genes using Boolean implications. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5732-7. Sahoo D, Seita J, Bhattacharya D, Inlay MA, Weissman IL, Plevritis SK, Dill DL. PMID: 20231483; PMCID: PMC2851930.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    29. Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev. 2009 Oct 15; 23(20):2376-81. Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL. PMID: 19833765; PMCID: PMC2764492.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    30. E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1930-5. Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C. PMID: 19181846; PMCID: PMC2644141.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    31. Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages. Blood. 2008 Jun 15; 111(12):5562-70. Karsunky H, Inlay MA, Serwold T, Bhattacharya D, Weissman IL. PMID: 18424665; PMCID: PMC2424154.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    32. Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol. 2007 Jul 15; 179(2):928-38. Serwold T, Hochedlinger K, Inlay MA, Jaenisch R, Weissman IL. PMID: 17617584.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    33. Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation. J Immunol. 2006 Jul 15; 177(2):1146-51. Inlay MA, Gao HH, Odegard VH, Lin T, Schatz DG, Xu Y. PMID: 16818772.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    34. Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci. J Exp Med. 2006 Jul 10; 203(7):1721-32. Inlay MA, Lin T, Gao HH, Xu Y. PMID: 16785310; PMCID: PMC2118354.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    35. Immunology in the spotlight at the Dover 'Intelligent Design' trial. Nat Immunol. 2006 May; 7(5):433-5. Bottaro A, Inlay MA, Matzke NJ. PMID: 16622425.
      View in: PubMed   Mentions: 3     Fields:    
    36. Important roles for E protein binding sites within the immunoglobulin kappa chain intronic enhancer in activating Vkappa Jkappa rearrangement. J Exp Med. 2004 Nov 01; 200(9):1205-11. Inlay MA, Tian H, Lin T, Xu Y. PMID: 15504821; PMCID: PMC2211861.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    37. Epigenetic regulation of antigen receptor rearrangement. Clin Immunol. 2003 Oct; 109(1):29-36. Inlay M, Xu Y. PMID: 14585273.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol. 2002 May; 3(5):463-8. Inlay M, Alt FW, Baltimore D, Xu Y. PMID: 11967540.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
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