Melissa Lodoen

Title(s)Associate Professor and Vice Chair, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address3238 McGaugh Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-7805
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    Collapse Research 
    Collapse Research Activities and Funding
    Neuroinflammation during cerebral Toxoplasma gondii infection
    NIH R21AI155122Mar 17, 2021 - Feb 28, 2023
    Role: Principal Investigator
    Role of caspase-8 in innate immunity to infection
    NIH R21AI156452Jan 22, 2021 - Dec 31, 2022
    Role: Principal Investigator
    T32 for Training in Microbiology and Infectious Diseases
    NIH T32AI141346Aug 19, 2019 - Jul 31, 2024
    Role: Principal Investigator
    Parasite dissemination in Toxoplasmic encephalitis
    NIH R01AI120846Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Parasite dissemination in Toxoplasmic encephalitis
    NIH R56AI120846Jul 21, 2015 - Feb 29, 2016
    Role: Principal Investigator
    Mechanisms of Toxoplasma gondii dissemination and transmigration
    NIH R56AI109074Aug 6, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Role for Caspase-8 in the Release of IL-1β and Active Caspase-1 from Viable Human Monocytes during Toxoplasma gondii Infection. J Immunol. 2024 Feb 19. Pandori WJ, Matsuno SY, Shin JH, Kim SC, Kao TH, Mallya S, Batarseh SN, Lodoen MB. PMID: 38372637.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Deficiency in astrocyte CCL2 production reduces neuroimmune control of Toxoplasma gondii infection. PLoS Pathog. 2024 Jan; 20(1):e1011710. Orchanian SB, Still K, Harris TH, Lodoen MB. PMID: 38206985; PMCID: PMC10807779.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. A transcriptional network required for bradyzoite development in Toxoplasma gondii is dispensable for recrudescent disease. Nat Commun. 2023 09 28; 14(1):6078. Sokol-Borrelli SL, Reilly SM, Holmes MJ, Orchanian SB, Massmann MD, Sharp KG, Cabo LF, Alrubaye HS, Martorelli Di Genova B, Lodoen MB, Sullivan WJ, Boyle JP. PMID: 37770433; PMCID: PMC10539341.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    4. Monocytes as primary defenders against Toxoplasma gondii infection. Trends Parasitol. 2023 10; 39(10):837-849. Orchanian SB, Lodoen MB. PMID: 37633758.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Capers with caspases: Toxoplasma gondii tales of inflammation and survival. Curr Opin Microbiol. 2023 04; 72:102264. Matsuno SY, Pandori WJ, Lodoen MB. PMID: 36791673.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Toxoplasma gondii Dissemination in the Brain Is Facilitated by Infiltrating Peripheral Immune Cells. mBio. 2022 12 20; 13(6):e0283822. Schneider CA, Figueroa Velez DX, Orchanian SB, Shallberg LA, Agalliu D, Hunter CA, Gandhi SP, Lodoen MB. PMID: 36445695; PMCID: PMC9765297.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Nanos gigantium humeris insidentes: old papers informing new research into Toxoplasma gondii. Int J Parasitol. 2021 12; 51(13-14):1193-1212. Lodoen MB, Smith NC, Soldati-Favre D, Ferguson DJP, van Dooren GG. PMID: 34736901; PMCID: PMC10538201.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases. mBio. 2021 01 26; 12(1). Lima TS, Mallya S, Jankeel A, Messaoudi I, Lodoen MB. PMID: 33500339; PMCID: PMC7858050.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Transcranial chronic optical access to longitudinally measure cerebral blood flow. J Neurosci Methods. 2021 02 15; 350:109044. Hoover EM, Crouzet C, Bordas JM, Figueroa Velez DX, Gandhi SP, Choi B, Lodoen MB. PMID: 33340556; PMCID: PMC8095351.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Sci Adv. 2020 12; 6(49). Meli VS, Atcha H, Veerasubramanian PK, Nagalla RR, Luu TU, Chen EY, Guerrero-Juarez CF, Yamaga K, Pandori W, Hsieh JY, Downing TL, Fruman DA, Lodoen MB, Plikus MV, Wang W, Liu WF. PMID: 33277245; PMCID: PMC7717914.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    11. Toxoplasma gondii Dysregulates Barrier Function and Mechanotransduction Signaling in Human Endothelial Cells. mSphere. 2020 Jan 29; 5(1). Franklin-Murray AL, Mallya S, Jankeel A, Sureshchandra S, Messaoudi I, Lodoen MB. PMID: 31996420; PMCID: PMC6992369.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Assessing Rhoptry Secretion in T. gondii. Methods Mol Biol. 2020; 2071:143-155. Suarez C, Lodoen MB, Lebrun M. PMID: 31758451.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Imaging the dynamic recruitment of monocytes to the blood-brain barrier and specific brain regions during Toxoplasma gondii infection. Proc Natl Acad Sci U S A. 2019 12 03; 116(49):24796-24807. Schneider CA, Figueroa Velez DX, Azevedo R, Hoover EM, Tran CJ, Lo C, Vadpey O, Gandhi SP, Lodoen MB. PMID: 31727842; PMCID: PMC6900744.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    14. Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes. PLoS Pathog. 2019 08; 15(8):e1007923. Pandori WJ, Lima TS, Mallya S, Kao TH, Gov L, Lodoen MB. PMID: 31449558; PMCID: PMC6730955.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    15. Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii. Front Cell Infect Microbiol. 2019; 9:103. Lima TS, Lodoen MB. PMID: 31041194; PMCID: PMC6476913.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    16. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. 2019 05; 67(5):844-856. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. PMID: 30588668; PMCID: PMC7375697.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    17. Correction to "Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture". ACS Cent Sci. 2018 11 28; 4(11):1593. Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP. PMID: 30555913; PMCID: PMC6276281.
      View in: PubMed   Mentions:
    18. A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion. mBio. 2018 10 02; 9(5). Coleman BI, Saha S, Sato S, Engelberg K, Ferguson DJP, Coppens I, Lodoen MB, Gubbels MJ. PMID: 30279285; PMCID: PMC6168857.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent Sci. 2018 Aug 22; 4(8):982-995. Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP. PMID: 30159395; PMCID: PMC6107863.
      View in: PubMed   Mentions: 23  
    20. Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection. mBio. 2018 02 13; 9(1). Lima TS, Gov L, Lodoen MB. PMID: 29440572; PMCID: PMC5821086.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    21. Toxoplasma gondii disrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility. J Biol Chem. 2018 03 02; 293(9):3374-3385. Cook JH, Ueno N, Lodoen MB. PMID: 29295815; PMCID: PMC5836128.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes during Toxoplasma gondii Infection. J Immunol. 2017 10 15; 199(8):2855-2864. Gov L, Schneider CA, Lima TS, Pandori W, Lodoen MB. PMID: 28904126; PMCID: PMC5648586.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    23. CD200 modulates macrophage cytokine secretion and phagocytosis in response to poly(lactic co-glycolic acid) microparticles and films. J Mater Chem B. 2017 Feb 28; 5(8):1574-1584. Chen EY, Chu S, Gov L, Kim YK, Lodoen MB, Tenner AJ, Liu WF. PMID: 28736613; PMCID: PMC5515357.
      View in: PubMed   Mentions: 13     Fields:    
    24. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nat Microbiol. 2016 Feb 15; 1:16001. Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. PMID: 27572166; PMCID: PMC4966557.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    25. From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system. Curr Opin Microbiol. 2015 Aug; 26:53-9. Ueno N, Lodoen MB. PMID: 26048316; PMCID: PMC10538213.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    26. Toxoplasma gondii dissemination: a parasite's journey through the infected host. Parasite Immunol. 2015 Mar; 37(3):141-9. Harker KS, Ueno N, Lodoen MB. PMID: 25408224.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimals
    27. Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo. Immunol Cell Biol. 2015 May-Jun; 93(5):508-13. Ueno N, Lodoen MB, Hickey GL, Robey EA, Coombes JL. PMID: 25533287; PMCID: PMC4446200.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses. Infect Immun. 2014 Oct; 82(10):4047-55. Morgado P, Sudarshana DM, Gov L, Harker KS, Lam T, Casali P, Boyle JP, Lodoen MB. PMID: 25024369; PMCID: PMC4187859.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    29. GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response. Infect Immun. 2014 Jun; 82(6):2595-605. Shastri AJ, Marino ND, Franco M, Lodoen MB, Boothroyd JC. PMID: 24711568; PMCID: PMC4019154.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    30. Shear forces enhance Toxoplasma gondii tachyzoite motility on vascular endothelium. mBio. 2014 Apr 01; 5(2):e01111-13. Harker KS, Jivan E, McWhorter FY, Liu WF, Lodoen MB. PMID: 24692639; PMCID: PMC3977363.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    31. Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. 2014 Apr; 16(4):580-95. Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB. PMID: 24245749; PMCID: PMC4141879.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. mBio. 2013 Jul 09; 4(4). Gov L, Karimzadeh A, Ueno N, Lodoen MB. PMID: 23839215; PMCID: PMC3705447.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    33. Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol. 2013 May; 93(5):789-800. Harker KS, Ueno N, Wang T, Bonhomme C, Liu W, Lodoen MB. PMID: 23485448.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    34. Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction. Infect Immun. 2011 Nov; 79(11):4401-12. Morgado P, Ong YC, Boothroyd JC, Lodoen MB. PMID: 21911468; PMCID: PMC3257910.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    35. Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions. Nat Methods. 2010 Apr; 7(4):307-9. Koshy AA, Fouts AE, Lodoen MB, Alkan O, Blau HM, Boothroyd JC. PMID: 20208532; PMCID: PMC2850821.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    36. 4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion. PLoS One. 2009 Dec 02; 4(12):e8143. Ravindran S, Lodoen MB, Verhelst SH, Bogyo M, Boothroyd JC. PMID: 19956582; PMCID: PMC2780294.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    37. A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection. Cell Microbiol. 2010 Jan; 12(1):55-66. Lodoen MB, Gerke C, Boothroyd JC. PMID: 19732057; PMCID: PMC3411547.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    38. Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response. J Exp Med. 2009 Mar 16; 206(3):515-23. Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM. PMID: 19255146; PMCID: PMC2699136.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    39. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. J Virol. 2008 Mar; 82(6):3021-30. Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE. PMID: 18094157; PMCID: PMC2259007.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    40. Natural killer cells as an initial defense against pathogens. Curr Opin Immunol. 2006 Aug; 18(4):391-8. Lodoen MB, Lanier LL. PMID: 16765573; PMCID: PMC7127478.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    41. NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system. Adv Exp Med Biol. 2006; 581:369-72. Walsh KB, Lodoen MB, Lanier LL, Lane TE. PMID: 17037561; PMCID: PMC7123950.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    42. Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat Genet. 2005 Jun; 37(6):593-9. Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM. PMID: 15895081; PMCID: PMC1200556.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    43. Viral modulation of NK cell immunity. Nat Rev Microbiol. 2005 Jan; 3(1):59-69. Lodoen MB, Lanier LL. PMID: 15608700.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    44. The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. J Exp Med. 2004 Oct 18; 200(8):1075-81. Lodoen MB, Abenes G, Umamoto S, Houchins JP, Liu F, Lanier LL. PMID: 15477345; PMCID: PMC2211837.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    45. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J Exp Med. 2003 May 19; 197(10):1245-53. Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier LL. PMID: 12756263; PMCID: PMC2193789.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
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