Lodoen, Melissa

Title(s)Associate Professor, Molecular Biology & Biochemistry
Phone(949) 824-7805
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    Collapse Research 
    Collapse Research Activities and Funding
    Parasite dissemination in Toxoplasmic encephalitis
    NIH/NIAID R01AI120846Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Parasite dissemination in Toxoplasmic encephalitis
    NIH/NIAID R56AI120846Jul 21, 2015 - Jun 30, 2016
    Role: Principal Investigator
    Mechanisms of Toxoplasma gondii dissemination and transmigration
    NIH/NIAID R56AI109074Aug 6, 2014 - Jul 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CM, Lodoen MB, Blurton-Jones M, Inlay MA. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. 2018 Dec 26. PMID: 30588668.
      View in: PubMed
    2. Coleman BI, Saha S, Sato S, Engelberg K, Ferguson DJP, Coppens I, Lodoen MB, Gubbels MJ. A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion. MBio. 2018 Oct 02; 9(5). PMID: 30279285.
      View in: PubMed
    3. Manna S, Howitz WJ, Oldenhuis NJ, Eldredge AC, Shen J, Nihesh FN, Lodoen MB, Guan Z, Esser-Kahn AP. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent Sci. 2018 Aug 22; 4(8):982-995. PMID: 30159395.
      View in: PubMed
    4. Lima TS, Gov L, Lodoen MB. Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection. MBio. 2018 02 13; 9(1). PMID: 29440572.
      View in: PubMed
    5. Cook JH, Ueno N, Lodoen MB. Toxoplasma gondii disrupts ß1 integrin signaling and focal adhesion formation during monocyte hypermotility. J Biol Chem. 2018 03 02; 293(9):3374-3385. PMID: 29295815.
      View in: PubMed
    6. Gov L, Schneider CA, Lima TS, Pandori W, Lodoen MB. NLRP3 and Potassium Efflux Drive Rapid IL-1ß Release from Primary Human Monocytes during Toxoplasma gondii Infection. J Immunol. 2017 10 15; 199(8):2855-2864. PMID: 28904126.
      View in: PubMed
    7. Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nat Microbiol. 2016 Feb 15; 1:16001. PMID: 27572166.
      View in: PubMed
    8. Ueno N, Lodoen MB. From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system. Curr Opin Microbiol. 2015 Aug; 26:53-9. PMID: 26048316.
      View in: PubMed
    9. Ueno N, Lodoen MB, Hickey GL, Robey EA, Coombes JL. Toxoplasma gondii-infected natural killer cells display a hypermotility phenotype in vivo. Immunol Cell Biol. 2015 May-Jun; 93(5):508-13. PMID: 25533287.
      View in: PubMed
    10. Morgado P, Sudarshana DM, Gov L, Harker KS, Lam T, Casali P, Boyle JP, Lodoen MB. Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses. Infect Immun. 2014 Oct; 82(10):4047-55. PMID: 25024369; PMCID: PMC4187859.
    11. Shastri AJ, Marino ND, Franco M, Lodoen MB, Boothroyd JC. GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response. Infect Immun. 2014 Jun; 82(6):2595-605. PMID: 24711568; PMCID: PMC4019154.
    12. Harker KS, Jivan E, McWhorter FY, Liu WF, Lodoen MB. Shear forces enhance Toxoplasma gondii tachyzoite motility on vascular endothelium. MBio. 2014 Apr 01; 5(2):e01111-13. PMID: 24692639; PMCID: PMC3977363.
    13. Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB. Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. 2014 Apr; 16(4):580-95. PMID: 24245749; PMCID: PMC4141879.
    14. Gov L, Karimzadeh A, Ueno N, Lodoen MB. Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. MBio. 2013 Jul 09; 4(4). PMID: 23839215; PMCID: PMC3705447.
    15. Harker KS, Ueno N, Wang T, Bonhomme C, Liu W, Lodoen MB. Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol. 2013 May; 93(5):789-800. PMID: 23485448.
      View in: PubMed
    16. Morgado P, Ong YC, Boothroyd JC, Lodoen MB. Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction. Infect Immun. 2011 Nov; 79(11):4401-12. PMID: 21911468; PMCID: PMC3257910.
    17. Koshy AA, Fouts AE, Lodoen MB, Alkan O, Blau HM, Boothroyd JC. Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions. Nat Methods. 2010 Apr; 7(4):307-9. PMID: 20208532; PMCID: PMC2850821.
    18. Ravindran S, Lodoen MB, Verhelst SH, Bogyo M, Boothroyd JC. 4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion. PLoS One. 2009 Dec 02; 4(12):e8143. PMID: 19956582; PMCID: PMC2780294.
    19. Lodoen MB, Gerke C, Boothroyd JC. A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection. Cell Microbiol. 2010 Jan; 12(1):55-66. PMID: 19732057; PMCID: PMC3411547.
    20. Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM. Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response. J Exp Med. 2009 Mar 16; 206(3):515-23. PMID: 19255146; PMCID: PMC2699136.
    21. Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. J Virol. 2008 Mar; 82(6):3021-30. PMID: 18094157; PMCID: PMC2259007.
    22. Lodoen MB, Lanier LL. Natural killer cells as an initial defense against pathogens. Curr Opin Immunol. 2006 Aug; 18(4):391-8. PMID: 16765573.
      View in: PubMed
    23. Walsh KB, Lodoen MB, Lanier LL, Lane TE. NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system. Adv Exp Med Biol. 2006; 581:369-72. PMID: 17037561.
      View in: PubMed
    24. Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM. Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat Genet. 2005 Jun; 37(6):593-9. PMID: 15895081; PMCID: PMC1200556.
    25. Lodoen MB, Lanier LL. Viral modulation of NK cell immunity. Nat Rev Microbiol. 2005 Jan; 3(1):59-69. PMID: 15608700.
      View in: PubMed
    26. Lodoen MB, Abenes G, Umamoto S, Houchins JP, Liu F, Lanier LL. The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. J Exp Med. 2004 Oct 18; 200(8):1075-81. PMID: 15477345; PMCID: PMC2211837.
    27. Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier LL. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J Exp Med. 2003 May 19; 197(10):1245-53. PMID: 12756263; PMCID: PMC2193789.