Stark, Craig E

Title(s)Professor, Neurobiology & Behavior
Phone(949) 824-4201
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    Collapse Research Activities and Funding
    Videogame-based environmental enrichment training for altercations in hippocampal function and memory in middle-aged adults
    NIH/NIA R21AG056145Aug 1, 2017 - May 31, 2019
    Role: Principal Investigator
    What is the relationship between BOLD fMRI and functional MRS in aging and MCI?
    NIH/NIA R21AG054092Sep 1, 2016 - May 31, 2018
    Role: Principal Investigator
    1H and 31P MR Spectroscopy of Hippocampal Hyperactivity in Aging and MCI
    NIH/NIA R21AG053040May 15, 2016 - Feb 28, 2018
    Role: Principal Investigator
    Neurophysiological And Fmri Studies Of Associative Learning In The Mtl And Striat
    NIH/NIMH R01MH085828Jul 5, 2010 - Apr 30, 2015
    Role: Principal Investigator
    High-Resolution Structural and Functional Brain Imaging of Medial Temporal Lobe i
    NIH/NIA R01AG034613Sep 15, 2009 - Apr 30, 2019
    Role: Principal Investigator
    Functional Imaging of Hippocampal Subfields in Healthy Aging
    NIH/NIA R03AG032015Sep 15, 2008 - Aug 31, 2011
    Role: Principal Investigator
    NIH/NIMH F32MH012278Jun 7, 1999
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Stark SM, Stark CEL. Excitatory/Inhibitory Imbalance in Anterior Lateral Occipital Complex Can Impair Hippocampal Mnemonic Discrimination. Neuron. 2019 Feb 06; 101(3):360-362. PMID: 30731057.
      View in: PubMed
    2. Frithsen A, Stark SM, Stark CEL. Response bias, recollection, and familiarity in individuals with Highly Superior Autobiographical Memory (HSAM). Memory. 2018 Dec 31; 1-11. PMID: 30596537.
      View in: PubMed
    3. Wais PE, Montgomery O, Stark CEL, Gazzaley A. Evidence of a Causal Role for mid-Ventrolateral Prefrontal Cortex Based Functional Networks in Retrieving High-Fidelity Memory. Sci Rep. 2018 Oct 05; 8(1):14877. PMID: 30291280.
      View in: PubMed
    4. Stark SM, Frithsen A, Mattfeld AT, Stark CEL. Modulation of associative learning in the hippocampal-striatal circuit based on item-set similarity. Cortex. 2018 Dec; 109:60-73. PMID: 30300757.
      View in: PubMed
    5. Bennett IJ, Stark SM, Stark CEL. Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults. J Gerontol B Psychol Sci Soc Sci. 2018 Feb 01. PMID: 29401233.
      View in: PubMed
    6. Stark SM, Stark CEL. Age-related deficits in the mnemonic similarity task for objects and scenes. Behav Brain Res. 2017 08 30; 333:109-117. PMID: 28673769.
      View in: PubMed
    7. Stark SM, Reagh ZM, Yassa MA, Stark CEL. What's in a context? Cautions, limitations, and potential paths forward. Neurosci Lett. 2018 07 27; 680:77-87. PMID: 28529173.
      View in: PubMed
    8. Huffman DJ, Stark CEL. The influence of low-level stimulus features on the representation of contexts, items, and their mnemonic associations. Neuroimage. 2017 07 15; 155:513-529. PMID: 28400264.
      View in: PubMed
    9. Nikolova S, Stark SM, Stark CEL. 3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging. Neurobiol Aging. 2017 06; 54:103-111. PMID: 28363111.
      View in: PubMed
    10. Wais PE, Jahanikia S, Steiner D, Stark CEL, Gazzaley A. Retrieval of high-fidelity memory arises from distributed cortical networks. Neuroimage. 2017 04 01; 149:178-189. PMID: 28159685.
      View in: PubMed
    11. Huffman DJ, Stark CE. Age-related impairment on a forced-choice version of the Mnemonic Similarity Task. Behav Neurosci. 2017 02; 131(1):55-67. PMID: 28004951.
      View in: PubMed
    12. Wisse LEM, Daugherty AM, Olsen RK, Berron D, Carr VA, Stark CEL, Amaral RSC, Amunts K, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren A, Chakravarty MM, Chupin M, Ekstrom A, de Flores R, Insausti R, Kanel P, Kedo O, Kennedy KM, Kerchner GA, LaRocque KF, Liu X, Maass A, Malykhin N, Mueller SG, Ofen N, Palombo DJ, Parekh MB, Pluta JB, Pruessner JC, Raz N, Rodrigue KM, Schoemaker D, Shafer AT, Steve TA, Suthana N, Wang L, Winterburn JL, Yassa MA, Yushkevich PA, la Joie R. A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus. 2017 01; 27(1):3-11. PMID: 27862600.
      View in: PubMed
    13. Mesina L, Wilber AA, Clark BJ, Dube S, Demecha AJ, Stark CE, McNaughton BL. A methodological pipeline for serial-section imaging and tissue realignment for whole-brain functional and connectivity assessment. J Neurosci Methods. 2016 06 15; 266:151-60. PMID: 27039972.
      View in: PubMed
    14. LePort AK, Stark SM, McGaugh JL, Stark CE. A cognitive assessment of highly superior autobiographical memory. Memory. 2017 02; 25(2):276-288. PMID: 26982996.
      View in: PubMed
    15. Saletin JM, Goldstein-Piekarski AN, Greer SM, Stark S, Stark CE, Walker MP. Human Hippocampal Structure: A Novel Biomarker Predicting Mnemonic Vulnerability to, and Recovery from, Sleep Deprivation. J Neurosci. 2016 Feb 24; 36(8):2355-63. PMID: 26911684; PMCID: PMC4764658.
    16. LePort AK, Stark SM, McGaugh JL, Stark CE. Highly Superior Autobiographical Memory: Quality and Quantity of Retention Over Time. Front Psychol. 2015; 6:2017. PMID: 26834661; PMCID: PMC4720782.
    17. Clemenson GD, Stark CE. Virtual Environmental Enrichment through Video Games Improves Hippocampal-Associated Memory. J Neurosci. 2015 Dec 09; 35(49):16116-25. PMID: 26658864; PMCID: PMC4682779.
    18. Bennett IJ, Stark CE. Mnemonic discrimination relates to perforant path integrity: An ultra-high resolution diffusion tensor imaging study. Neurobiol Learn Mem. 2016 Mar; 129:107-12. PMID: 26149893; PMCID: PMC4699874 [Available on 03/01/17].
    19. Stark SM, Stevenson R, Wu C, Rutledge S, Stark CE. Stability of age-related deficits in the mnemonic similarity task across task variations. Behav Neurosci. 2015 Jun; 129(3):257-68. PMID: 26030427; PMCID: PMC4451612.
    20. Allen TA, Morris AM, Stark SM, Fortin NJ, Stark CE. Memory for sequences of events impaired in typical aging. Learn Mem. 2015 Mar; 22(3):138-48. PMID: 25691514; PMCID: PMC4340129.
    21. Mattfeld AT, Stark CE. Functional contributions and interactions between the human hippocampus and subregions of the striatum during arbitrary associative learning and memory. Hippocampus. 2015 Aug; 25(8):900-11. PMID: 25560298; PMCID: PMC4492918.
    22. Yushkevich PA, Amaral RS, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren AC, Carr VA, Chakravarty MM, Ch├ętelat G, Daugherty AM, Davachi L, Ding SL, Ekstrom A, Geerlings MI, Hassan A, Huang Y, Iglesias JE, La Joie R, Kerchner GA, LaRocque KF, Libby LA, Malykhin N, Mueller SG, Olsen RK, Palombo DJ, Parekh MB, Pluta JB, Preston AR, Pruessner JC, Ranganath C, Raz N, Schlichting ML, Schoemaker D, Singh S, Stark CE, Suthana N, Tompary A, Turowski MM, Van Leemput K, Wagner AD, Wang L, Winterburn JL, Wisse LE, Yassa MA, Zeineh MM. Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol. Neuroimage. 2015 May 01; 111:526-41. PMID: 25596463.
      View in: PubMed
    23. Das T, Ivleva EI, Wagner AD, Stark CE, Tamminga CA. Loss of pattern separation performance in schizophrenia suggests dentate gyrus dysfunction. Schizophr Res. 2014 Oct; 159(1):193-7. PMID: 25176349; PMCID: PMC4177293.
    24. Huffman DJ, Stark CE. Multivariate pattern analysis of the human medial temporal lobe revealed representationally categorical cortex and representationally agnostic hippocampus. Hippocampus. 2014 Nov; 24(11):1394-403. PMID: 24976498; PMCID: PMC4197092.
    25. Allen TA, Morris AM, Mattfeld AT, Stark CE, Fortin NJ. A Sequence of events model of episodic memory shows parallels in rats and humans. Hippocampus. 2014 Oct; 24(10):1178-88. PMID: 24802767.
      View in: PubMed
    26. Bennett IJ, Huffman DJ, Stark CE. Limbic Tract Integrity Contributes to Pattern Separation Performance Across the Lifespan. Cereb Cortex. 2015 Sep; 25(9):2988-99. PMID: 24825784; PMCID: PMC4553719.
    27. Patihis L, Frenda SJ, LePort AK, Petersen N, Nichols RM, Stark CE, McGaugh JL, Loftus EF. False memories in highly superior autobiographical memory individuals. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20947-52. PMID: 24248358; PMCID: PMC3876244.
    28. Azab M, Stark SM, Stark CE. Contributions of human hippocampal subfields to spatial and temporal pattern separation. Hippocampus. 2014 Mar; 24(3):293-302. PMID: 24167043; PMCID: PMC3933274.
    29. Lacy JW, Stark CEL. The neuroscience of memory: implications for the courtroom. Nat Rev Neurosci. 2013 09; 14(9):649-658. PMID: 23942467; PMCID: PMC4183265.
    30. Stark SM, Yassa MA, Lacy JW, Stark CE. A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment. Neuropsychologia. 2013 Oct; 51(12):2442-9. PMID: 23313292; PMCID: PMC3675184.
    31. Lacy JW, Stark CE. Intrinsic functional connectivity of the human medial temporal lobe suggests a distinction between adjacent MTL cortices and hippocampus. Hippocampus. 2012 Dec; 22(12):2290-302. PMID: 22736526; PMCID: PMC3764462.
    32. Brock Kirwan C, Hartshorn A, Stark SM, Goodrich-Hunsaker NJ, Hopkins RO, Stark CE. Pattern separation deficits following damage to the hippocampus. Neuropsychologia. 2012 Aug; 50(10):2408-14. PMID: 22732491; PMCID: PMC3411917.
    33. LePort AK, Mattfeld AT, Dickinson-Anson H, Fallon JH, Stark CE, Kruggel F, Cahill L, McGaugh JL. Behavioral and neuroanatomical investigation of Highly Superior Autobiographical Memory (HSAM). Neurobiol Learn Mem. 2012 Jul; 98(1):78-92. PMID: 22652113; PMCID: PMC3764458.
    34. Hargreaves EL, Mattfeld AT, Stark CE, Suzuki WA. Conserved fMRI and LFP signals during new associative learning in the human and macaque monkey medial temporal lobe. Neuron. 2012 May 24; 74(4):743-52. PMID: 22632731; PMCID: PMC3969034.
    35. Bakker A, Krauss GL, Albert MS, Speck CL, Jones LR, Stark CE, Yassa MA, Bassett SS, Shelton AL, Gallagher M. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron. 2012 May 10; 74(3):467-74. PMID: 22578498; PMCID: PMC3351697.
    36. Yassa MA, Hazlett RL, Stark CE, Hoehn-Saric R. Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder. J Psychiatr Res. 2012 Aug; 46(8):1045-52. PMID: 22575329; PMCID: PMC3893050.
    37. Segal SK, Stark SM, Kattan D, Stark CE, Yassa MA. Norepinephrine-mediated emotional arousal facilitates subsequent pattern separation. Neurobiol Learn Mem. 2012 May; 97(4):465-9. PMID: 22498686; PMCID: PMC3517207.
    38. Stark CE. It is time to fill in the gaps left by simple dissociations. Cogn Neurosci. 2012; 3(3-4):215-6. PMID: 24171742.
      View in: PubMed
    39. Mattfeld AT, Gluck MA, Stark CE. Functional specialization within the striatum along both the dorsal/ventral and anterior/posterior axes during associative learning via reward and punishment. Learn Mem. 2011; 18(11):703-11. PMID: 22021252; PMCID: PMC3207255.
    40. Yassa MA, Stark CE. Pattern separation in the hippocampus. Trends Neurosci. 2011 Oct; 34(10):515-25. PMID: 21788086; PMCID: PMC3183227.
    41. Yassa MA, Mattfeld AT, Stark SM, Stark CE. Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8873-8. PMID: 21555581; PMCID: PMC3102362.
    42. Lacy JW, Yassa MA, Stark SM, Muftuler LT, Stark CE. Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn Mem. 2011 Jan; 18(1):15-8. PMID: 21164173; PMCID: PMC3023966.
    43. Stark CE, Okado Y, Loftus EF. Imaging the reconstruction of true and false memories using sensory reactivation and the misinformation paradigms. Learn Mem. 2010 Oct; 17(10):485-8. PMID: 20861170.
      View in: PubMed
    44. Mattfeld AT, Stark CE. Striatal and medial temporal lobe functional interactions during visuomotor associative learning. Cereb Cortex. 2011 Mar; 21(3):647-58. PMID: 20688877; PMCID: PMC3297014.
    45. Yassa MA, Muftuler LT, Stark CE. Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12687-91. PMID: 20616040; PMCID: PMC2906542.
    46. Stark SM, Yassa MA, Stark CE. Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learn Mem. 2010 Jun; 17(6):284-8. PMID: 20495062; PMCID: PMC2884287.
    47. Yassa MA, Lacy JW, Stark SM, Albert MS, Gallagher M, Stark CE. Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus. 2011 Sep; 21(9):968-79. PMID: 20865732; PMCID: PMC3010452.
    48. Yassa MA, Stark SM, Bakker A, Albert MS, Gallagher M, Stark CE. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment. Neuroimage. 2010 Jul 01; 51(3):1242-52. PMID: 20338246; PMCID: PMC2909476.
    49. Yassa MA, Stark CE. A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. Neuroimage. 2009 Jan 15; 44(2):319-27. PMID: 18929669.
      View in: PubMed
    50. Bakker A, Kirwan CB, Miller M, Stark CE. Pattern separation in the human hippocampal CA3 and dentate gyrus. Science. 2008 Mar 21; 319(5870):1640-2. PMID: 18356518; PMCID: PMC2829853.
    51. Stark S, Gordon B, Stark C. A case study of amnesia: exploring a paradigm for new semantic learning and generalization. Brain Inj. 2008 Mar; 22(3):283-92. PMID: 18297600.
      View in: PubMed
    52. Stark SM, Gordon B, Stark CE. Does the presence of priming hinder subsequent recognition or recall performance? Memory. 2008 Feb; 16(2):157-73. PMID: 18286420.
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    53. Yassa MA, Stark CE. Multiple signals of recognition memory in the medial temporal lobe. Hippocampus. 2008; 18(9):945-54. PMID: 18493928.
      View in: PubMed
    54. Kirwan CB, Jones CK, Miller MI, Stark CE. High-resolution fMRI investigation of the medial temporal lobe. Hum Brain Mapp. 2007 Oct; 28(10):959-66. PMID: 17133381; PMCID: PMC2853185.
    55. Kirwan CB, Stark CE. Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe. Learn Mem. 2007 Sep; 14(9):625-33. PMID: 17848502; PMCID: PMC1994079.
    56. Gold JJ, Smith CN, Bayley PJ, Shrager Y, Brewer JB, Stark CE, Hopkins RO, Squire LR. Item memory, source memory, and the medial temporal lobe: concordant findings from fMRI and memory-impaired patients. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9351-6. PMID: 16751272; PMCID: PMC1482613.
    57. Izard C, Jedynak B, Stark CE. Spline-based probabilistic model for anatomical landmark detection. Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):849-56. PMID: 17354970.
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    58. Miller MI, Beg MF, Ceritoglu C, Stark C. Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9685-90. PMID: 15980148; PMCID: PMC1172268.
    59. Law JR, Flanery MA, Wirth S, Yanike M, Smith AC, Frank LM, Suzuki WA, Brown EN, Stark CE. Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory. J Neurosci. 2005 Jun 15; 25(24):5720-9. PMID: 15958738.
      View in: PubMed
    60. Stark C, Stark S, Gordon B. New semantic learning and generalization in a patient with amnesia. Neuropsychology. 2005 Mar; 19(2):139-51. PMID: 15769198.
      View in: PubMed
    61. Okado Y, Stark CE. Neural activity during encoding predicts false memories created by misinformation. Learn Mem. 2005 Jan-Feb; 12(1):3-11. PMID: 15687227; PMCID: PMC548489.
    62. Kirwan CB, Stark CE. Medial temporal lobe activation during encoding and retrieval of novel face-name pairs. Hippocampus. 2004; 14(7):919-30. PMID: 15382260; PMCID: PMC2704554.
    63. Squire LR, Stark CE, Clark RE. The medial temporal lobe. Annu Rev Neurosci. 2004; 27:279-306. PMID: 15217334.
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    64. Okado Y, Stark C. Neural processing associated with true and false memory retrieval. Cogn Affect Behav Neurosci. 2003 Dec; 3(4):323-34. PMID: 15040552.
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    65. Stark CE, Okado Y. Making memories without trying: medial temporal lobe activity associated with incidental memory formation during recognition. J Neurosci. 2003 Jul 30; 23(17):6748-53. PMID: 12890767.
      View in: PubMed
    66. Stark CE, Squire LR. Hippocampal damage equally impairs memory for single items and memory for conjunctions. Hippocampus. 2003; 13(2):281-92. PMID: 12699335; PMCID: PMC2754398.
    67. Stark CE, Bayley PJ, Squire LR. Recognition memory for single items and for associations is similarly impaired following damage to the hippocampal region. Learn Mem. 2002 Sep-Oct; 9(5):238-42. PMID: 12359833; PMCID: PMC187132.