Zhou, Qun-Yong

Title(s)Professor, Pharmacology
Phone(949) 824-2232, 1902
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of glucose homeostasis by prokineticin 2 signaling
    NIH/NIDDK R21DK091916Aug 5, 2011 - Jul 31, 2014
    Role: Principal Investigator
    Prokineticin 2 and Suprachiasmatic Circadian Output
    NIH/NIMH R01MH067753Sep 24, 2004 - Jun 30, 2010
    Role: Principal Investigator
    NIH/NIMH R29MH057889Jul 1, 1998 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li X, Zhang C, Zhou QY. Overexpression of Prokineticin 2 in Transgenic Mice Leads to Reduced Circadian Behavioral Rhythmicity and Altered Molecular Rhythms in the Suprachiasmatic Clock. J Circadian Rhythms. 2018 Nov 06; 16:13. PMID: 30473715.
      View in: PubMed
    2. Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nat Commun. 2016 10 05; 7:12932. PMID: 27703142.
      View in: PubMed
    3. Zhou QY, Burton KJ, Neal ML, Qiao Y, Kanthasamy AG, Sun Y, Xu X, Ma Y, Li X. Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey. Mol Brain. 2016 08 18; 9(1):78. PMID: 27535380; PMCID: PMC4989352.
    4. Burton KJ, Li X, Li B, Cheng MY, Urbanski HF, Zhou QY. Expression of prokineticin 2 and its receptor in the macaque monkey brain. Chronobiol Int. 2016; 33(2):191-9. PMID: 26818846; PMCID: PMC4959799 [Available on 01/28/17].
    5. Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, Desvergne B, Hoffmann P, Zhou QY, Congiu C, Onnis V, Benharouga M, Feige JJ, Alfaidy N. PPAR? controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development. Am J Physiol Endocrinol Metab. 2015 Aug 15; 309(4):E357-69. PMID: 26081281.
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    6. Burton KJ, Li X, Li JD, Hu WP, Zhou QY. Rhythmic Trafficking of TRPV2 in the Suprachiasmatic Nucleus is Regulated by Prokineticin 2 Signaling. J Circadian Rhythms. 2015 Apr 01; 13:2. PMID: 27103928; PMCID: PMC4832818.
    7. Qiu F, Qiu CY, Cai H, Liu TT, Qu ZW, Yang Z, Li JD, Zhou QY, Hu WP. Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin, V1A receptor in primary sensory neurons. Br J Pharmacol. 2014 Jun; 171(12):3065-76. PMID: 24641084; PMCID: PMC4055206.
    8. Chen DN, Ma YT, Liu H, Zhou QY, Li JD. Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. J Biol Chem. 2014 May 30; 289(22):15518-26. PMID: 24753254; PMCID: PMC4140907.
    9. Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, Crowley W WF, Hastings MH, Zhou QY. Signaling role of prokineticin 2 on the estrous cycle of female mice. PLoS One. 2014; 9(3):e90860. PMID: 24633064; PMCID: PMC3954593.
    10. Ding SL, Wang JX, Jiao JQ, Tu X, Wang Q, Liu F, Li Q, Gao J, Zhou QY, Gu DF, Li PF. A pre-microRNA-149 (miR-149) genetic variation affects miR-149 maturation and its ability to regulate the Puma protein in apoptosis. J Biol Chem. 2013 Sep 13; 288(37):26865-77. PMID: 23873935; PMCID: PMC3772234.
    11. Curtis VF, Wang H, Yang P, McLendon RE, Li X, Zhou QY, Wang XF. A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. PLoS One. 2013; 8(1):e54916. PMID: 23372791; PMCID: PMC3553000.
    12. Zhou W, Li JD, Hu WP, Cheng MY, Zhou QY. Prokineticin 2 is involved in the thermoregulation and energy expenditure. Regul Pept. 2012 Nov 10; 179(1-3):84-90. PMID: 22960406.
      View in: PubMed
    13. Qiu CY, Liu YQ, Qiu F, Wu J, Zhou QY, Hu WP. Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons. J Neuroinflammation. 2012 May 29; 9:108. PMID: 22642848; PMCID: PMC3413530.
    14. Cheng MY, Lee AG, Culbertson C, Sun G, Talati RK, Manley NC, Li X, Zhao H, Lyons DM, Zhou QY, Steinberg GK, Sapolsky RM. Prokineticin 2 is an endangering mediator of cerebral ischemic injury. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5475-80. PMID: 22431614; PMCID: PMC3325724.
    15. Raivio T, Avbelj M, McCabe MJ, Romero CJ, Dwyer AA, Tommiska J, Sykiotis GP, Gregory LC, Diaczok D, Tziaferi V, Elting MW, Padidela R, Plummer L, Martin C, Feng B, Zhang C, Zhou QY, Chen H, Mohammadi M, Quinton R, Sidis Y, Radovick S, Dattani MT, Pitteloud N. Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia. J Clin Endocrinol Metab. 2012 Apr; 97(4):E694-9. PMID: 22319038; PMCID: PMC3319178.
    16. Li JD, Hu WP, Zhou QY. The circadian output signals from the suprachiasmatic nuclei. Prog Brain Res. 2012; 199:119-27. PMID: 22877662.
      View in: PubMed
    17. Ren P, Zhang H, Qiu F, Liu YQ, Gu H, O'Dowd DK, Zhou QY, Hu WP. Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons. PLoS One. 2011; 6(6):e20263. PMID: 21687716; PMCID: PMC3110640.
    18. Balasubramanian R, Plummer L, Sidis Y, Pitteloud N, Martin C, Zhou QY, Crowley WF. The puzzles of the prokineticin 2 pathway in human reproduction. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):44-50. PMID: 21664414; PMCID: PMC3216477.
    19. Zhou Q, Dergunov SA, Zhang Y, Li X, Mu Q, Zhang Q, Jiang G, Pinkhassik E, Yan B. Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls. Nanoscale. 2011 Jun; 3(6):2576-82. PMID: 21509382.
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    20. Hu WP, Li JD, Colwell CS, Zhou QY. Decreased REM sleep and altered circadian sleep regulation in mice lacking vasoactive intestinal polypeptide. Sleep. 2011 Jan 01; 34(1):49-56. PMID: 21203371; PMCID: PMC3001794.
    21. Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF. The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev. 2011 Apr; 32(2):225-46. PMID: 21037178; PMCID: PMC3365793.
    22. Zhang C, Truong KK, Zhou QY. Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus. PLoS One. 2009 Sep 28; 4(9):e7151. PMID: 19784373; PMCID: PMC2747004.
    23. Li JD, Burton KJ, Zhang C, Hu SB, Zhou QY. Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R824-30. PMID: 19052319; PMCID: PMC2665843.
    24. Shapiro LA, Ng K, Zhou QY, Ribak CE. Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. Epilepsy Behav. 2009 Jan; 14 Suppl 1:74-80. PMID: 18849007; PMCID: PMC2677571.
    25. Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF, Zhou QY, Pitteloud N. Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. J Clin Endocrinol Metab. 2008 Sep; 93(9):3551-9. PMID: 18559922; PMCID: PMC2567850.
    26. Li JD, Hu WP, Zhou QY. Disruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in mice. Neuropsychopharmacology. 2009 Jan; 34(2):367-73. PMID: 18432189; PMCID: PMC2667318.
    27. Civelli O, Zhou QY. Orphan G protein-coupled receptors and novel neuropeptides. Introduction. Results Probl Cell Differ. 2008; 46:v-vi. PMID: 18634199.
      View in: PubMed
    28. Zhou QY, Meidan R. Biological function of prokineticins. Results Probl Cell Differ. 2008; 46:181-99. PMID: 18202926.
      View in: PubMed
    29. Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF. Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17447-52. PMID: 17959774; PMCID: PMC2077276.
    30. Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE. Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Struct Funct. 2007 Sep; 212(2):133-48. PMID: 17764016.
      View in: PubMed
    31. Shapiro LA, Ng KL, Zhou QY, Ribak CE. Olfactory enrichment enhances the survival of newly born cortical neurons in adult mice. Neuroreport. 2007 Jul 02; 18(10):981-5. PMID: 17558281.
      View in: PubMed
    32. Hu WP, Li JD, Zhang C, Boehmer L, Siegel JM, Zhou QY. Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice. Sleep. 2007 Mar; 30(3):247-56. PMID: 17425220; PMCID: PMC2673012.
    33. Zhang C, Ng KL, Li JD, He F, Anderson DJ, Sun YE, Zhou QY. Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis. J Biol Chem. 2007 Mar 09; 282(10):6917-21. PMID: 17259180.
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    34. Kisliouk T, Friedman A, Klipper E, Zhou QY, Schams D, Alfaidy N, Meidan R. Expression pattern of prokineticin 1 and its receptors in bovine ovaries during the estrous cycle: involvement in corpus luteum regression and follicular atresia. Biol Reprod. 2007 May; 76(5):749-58. PMID: 17229935.
      View in: PubMed
    35. Yuill EA, Hoyda TD, Ferri CC, Zhou QY, Ferguson AV. Prokineticin 2 depolarizes paraventricular nucleus magnocellular and parvocellular neurons. Eur J Neurosci. 2007 Jan; 25(2):425-34. PMID: 17284183.
      View in: PubMed
    36. Zhou QY. The prokineticins: a novel pair of regulatory peptides. Mol Interv. 2006 Dec; 6(6):330-8. PMID: 17200460; PMCID: PMC2667320.
    37. Hu WP, Zhang C, Li JD, Luo ZD, Amadesi S, Bunnett N, Zhou QY. Impaired pain sensation in mice lacking prokineticin 2. Mol Pain. 2006 Nov 15; 2:35. PMID: 17107623; PMCID: PMC1660571.
    38. Li JD, Hu WP, Boehmer L, Cheng MY, Lee AG, Jilek A, Siegel JM, Zhou QY. Attenuated circadian rhythms in mice lacking the prokineticin 2 gene. J Neurosci. 2006 Nov 08; 26(45):11615-23. PMID: 17093083; PMCID: PMC2713041.
    39. Cheng MY, Leslie FM, Zhou QY. Expression of prokineticins and their receptors in the adult mouse brain. J Comp Neurol. 2006 Oct 20; 498(6):796-809. PMID: 16927269; PMCID: PMC2667319.
    40. Podlovni H, Ovadia O, Kisliouk T, Klipper E, Zhou QY, Friedman A, Alfaidy N, Meidan R. Differential expression of prokineticin receptors by endothelial cells derived from different vascular beds: a physiological basis for distinct endothelial function. Cell Physiol Biochem. 2006; 18(6):315-26. PMID: 17170518.
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    41. Zhou QY, Cheng MY. Prokineticin 2 and circadian clock output. FEBS J. 2005 Nov; 272(22):5703-9. PMID: 16279936; PMCID: PMC2667323.
    42. Ng KL, Li JD, Cheng MY, Leslie FM, Lee AG, Zhou QY. Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science. 2005 Jun 24; 308(5730):1923-7. PMID: 15976302.
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    43. Kisliouk T, Podlovni H, Spanel-Borowski K, Ovadia O, Zhou QY, Meidan R. Prokineticins (endocrine gland-derived vascular endothelial growth factor and BV8) in the bovine ovary: expression and role as mitogens and survival factors for corpus luteum-derived endothelial cells. Endocrinology. 2005 Sep; 146(9):3950-8. PMID: 15932929.
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    44. Cheng MY, Bittman EL, Hattar S, Zhou QY. Regulation of prokineticin 2 expression by light and the circadian clock. BMC Neurosci. 2005 Mar 11; 6:17. PMID: 15762991; PMCID: PMC555564.
    45. Cottrell GT, Zhou QY, Ferguson AV. Prokineticin 2 modulates the excitability of subfornical organ neurons. J Neurosci. 2004 Mar 10; 24(10):2375-9. PMID: 15014112.
      View in: PubMed
    46. Bullock CM, Li JD, Zhou QY. Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists. Mol Pharmacol. 2004 Mar; 65(3):582-8. PMID: 14978236.
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    47. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002 May 23; 417(6887):405-10. PMID: 12024206.
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    48. Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. J Biol Chem. 2002 May 31; 277(22):19276-80. PMID: 11886876.
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    49. Li M, Li C, Weingarten P, Bunzow JR, Grandy DK, Zhou QY. Association of dopamine D(3) receptors with actin-binding protein 280 (ABP-280). Biochem Pharmacol. 2002 Mar 01; 63(5):859-63. PMID: 11911837.
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    50. Bermak JC, Li M, Bullock C, Weingarten P, Zhou QY. Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus. Eur J Cell Biol. 2002 Feb; 81(2):77-85. PMID: 11893085.
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