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Razorenova, Olga

Title(s)Assistant Professor, Molecular Biology & Biochemistry
Phone(949) 824-8156
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    Collapse Research 
    Collapse Research Activities and Funding
    Synthetic lethality in VHL tumor suppressor null tumors
    NIH/NCI R03CA202563Dec 2, 2015 - Nov 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Thompson JM, Alvarez A, Singha MK, Pavesic MW, Nguyen QH, Nelson LJ, Fruman DA, Razorenova OV. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol Cancer Ther. 2018 Aug; 17(8):1781-1792. PMID: 29720560.
      View in: PubMed
    2. Wright HJ, Hou J, Xu B, Cortez M, Potma EO, Tromberg BJ, Razorenova OV. CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6556-E6565. PMID: 28739932.
      View in: PubMed
    3. Thompson JM, Landman J, Razorenova OV. Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers. Small GTPases. 2017 Jun 20; 1-7. PMID: 28632992.
      View in: PubMed
    4. Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017 Apr 20; 45(7):3674-3692. PMID: 28073943.
      View in: PubMed
    5. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017 02 23; 36(8):1080-1089. PMID: 27841867.
      View in: PubMed
    6. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. PMID: 27475528.
      View in: PubMed
    7. Wright HJ, Police AM, Razorenova OV. Targeting CDCP1 dimerization in triple-negative breast cancer. Cell Cycle. 2016 09 16; 15(18):2385-6. PMID: 27362899.
      View in: PubMed
    8. Hou J, Wright HJ, Chan N, Tran R, Razorenova OV, Potma EO, Tromberg BJ. Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption. J Biomed Opt. 2016 06 01; 21(6):60503. PMID: 27300321.
      View in: PubMed
    9. Wright HJ, Arulmoli J, Motazedi M, Nelson LJ, Heinemann FS, Flanagan LA, Razorenova OV. CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene. 2016 09 08; 35(36):4762-72. PMID: 26876198.
      View in: PubMed
    10. Thompson JM, Nguyen QH, Singh M, Razorenova OV. Approaches to identifying synthetic lethal interactions in cancer. Yale J Biol Med. 2015 Jun; 88(2):145-55. PMID: 26029013; PMCID: PMC4445436.
    11. Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol. 2014 Feb; 34(4):739-51. PMID: 24344197; PMCID: PMC3911479.
    12. Chernikova SB, Razorenova OV, Higgins JP, Sishc BJ, Nicolau M, Dorth JA, Chernikova DA, Kwok S, Brooks JD, Bailey SM, Game JC, Brown JM. Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res. 2012 Apr 15; 72(8):2111-9. PMID: 22354749.
      View in: PubMed
    13. Razorenova OV. Brain and muscle ARNT-like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to hypoxia-inducible factor-mediated pathway. Cell Cycle. 2012 Jan 15; 11(2):213-4. PMID: 22223094.
      View in: PubMed
    14. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1931-6. PMID: 21233420.
      View in: PubMed
    15. Chernikova SB, Dorth JA, Razorenova OV, Game JC, Brown JM. Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells. Radiat Res. 2010 Nov; 174(5):558-65. PMID: 20738173.
      View in: PubMed
    16. Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, Ly DP, Butler PD, Yang GP, Joshua B, Kaplan MJ, Longaker MT, Weissman IL. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature. 2010 Jul 01; 466(7302):133-7. PMID: 20596026.
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    17. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010 Jan; 30(1):344-53. PMID: 19858293.
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    18. Malinin NL, Zhang L, Choi J, Ciocea A, Razorenova O, Ma YQ, Podrez EA, Tosi M, Lennon DP, Caplan AI, Shurin SB, Plow EF, Byzova TV. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med. 2009 Mar; 15(3):313-8. PMID: 19234460.
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    19. Mahabeleshwar GH, Chen J, Feng W, Somanath PR, Razorenova OV, Byzova TV. Integrin affinity modulation in angiogenesis. Cell Cycle. 2008 Feb 01; 7(3):335-47. PMID: 18287811.
      View in: PubMed
    20. Somanath PR, Razorenova OV, Chen J, Byzova TV. Akt1 in endothelial cell and angiogenesis. Cell Cycle. 2006 Mar; 5(5):512-8. PMID: 16552185.
      View in: PubMed
    21. Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev. 2006 Jan 15; 20(2):236-52. PMID: 16418486; PMCID: PMC1356114.
    22. Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med. 2005 Nov; 11(11):1188-96. PMID: 16227992; PMCID: PMC2277080.
    23. De S, Razorenova O, McCabe NP, O'Toole T, Qin J, Byzova TV. VEGF-integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7589-94. PMID: 15897451; PMCID: PMC1129024.
    24. Razorenova OV, Ivanov AV, Budanov AV, Chumakov PM. Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1. Gene. 2005 Apr 25; 350(1):89-98. PMID: 15794924.
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    25. Narizhneva NV, Razorenova OV, Podrez EA, Chen J, Chandrasekharan UM, DiCorleto PE, Plow EF, Topol EJ, Byzova TV. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 2005 Jul; 19(9):1158-60. PMID: 15833768; PMCID: PMC1569946.
    26. Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM. [Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors]. Mol Biol (Mosk). 2005 Mar-Apr; 39(2):286-93. PMID: 15856952.
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    27. Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res. 2004 Mar 15; 64(6):1951-8. PMID: 15026329.
      View in: PubMed
    28. Kusulidu LK, Karpova NN, Razorenova OV, Glukhov IA, Kim AI, Liubomirskaia NV, Il'in IuV. [Mobile genetic element MDG4 (gypsy) in Drosophila melanogaster. Features of structure and regulation of transposition]. Genetika. 2001 Dec; 37(12):1589-97. PMID: 11785284.
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    29. Lyubomirskaya NV, Smirnova JB, Razorenova OV, Karpova NN, Surkov SA, Avedisov SN, Kim AI, Ilyin YV. Two variants of the Drosophila melanogaster retrotransposon gypsy (mdg4): structural and functional differences, and distribution in fly stocks. Mol Genet Genomics. 2001 Apr; 265(2):367-74. PMID: 11361349.
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    30. Razorenova OV, Karpova NN, Smirnova IuB, Kusulidu LK, Reneva NK, Subocheva EA, Kim AI, Liubomirskaia NV, Il'in IuV. [Interlineage distribution and characteristics of the structure of two subfamilies of Drosophila melanogaster MDG4 (gypsy) retrotransposon]. Genetika. 2001 Feb; 37(2):175-82. PMID: 11253423.
      View in: PubMed
    31. Kim AI, Pasiukova EG, Karpova NN, Razorenova OV. [Genomic factors regulating the transposition of drosophila mobile elements]. Genetika. 1999 Nov; 35(11):1511-21. PMID: 10624574.
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