Olga Razorenova

Title(s)Assistant Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address3010 Gross Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-8156
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    Collapse Research 
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    Synthetic lethality in VHL tumor suppressor null tumors
    NIH R03CA202563Dec 2, 2015 - Nov 30, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Synthetic lethality of cyclin-dependent kinase inhibitor Dinaciclib with VHL-deficiency allows for selective targeting of clear cell renal cell carcinoma. Cell Cycle. 2022 05; 21(10):1103-1119. Nelson LJ, Castro KE, Xu B, Li J, Dinh NB, Thompson JM, Woytash J, Kipp KR, Razorenova OV. PMID: 35240916; PMCID: PMC9037521.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. A Machine Learning-Assisted Nanoparticle-Printed Biochip for Real-Time Single Cancer Cell Analysis. Adv Biosyst. 2020 11; 4(11):e2000160. Joshi K, Javani A, Park J, Velasco V, Xu B, Razorenova O, Esfandyarpour R. PMID: 33025770.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    3. Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers. Am J Pathol. 2020 02; 190(2):484-502. Nelson LJ, Wright HJ, Dinh NB, Nguyen KD, Razorenova OV, Heinemann FS. PMID: 31843498; PMCID: PMC6983918.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. EMBO J. 2020 01 02; 39(1):e102406. Vargas RE, Duong VT, Han H, Ta AP, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova OV, Chen J, Luo R, Li X, Wang W. PMID: 31782549; PMCID: PMC6939200.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    5. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol Cancer Ther. 2018 08; 17(8):1781-1792. Thompson JM, Alvarez A, Singha MK, Pavesic MW, Nguyen QH, Nelson LJ, Fruman DA, Razorenova OV. PMID: 29720560; PMCID: PMC6072609.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    6. CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6556-E6565. Wright HJ, Hou J, Xu B, Cortez M, Potma EO, Tromberg BJ, Razorenova OV. PMID: 28739932; PMCID: PMC5559020.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    7. Targeting the RhoGTPase/ROCK pathway for the treatment of VHL/HIF pathway-driven cancers. Small GTPases. 2020 01; 11(1):32-38. Thompson JM, Landman J, Razorenova OV. PMID: 28632992; PMCID: PMC6959287.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017 04 20; 45(7):3674-3692. Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. PMID: 28073943; PMCID: PMC5397198.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    9. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017 02 23; 36(8):1080-1089. Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV. PMID: 27841867; PMCID: PMC5323317.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    10. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. PMID: 27475528; PMCID: PMC5386322.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    11. Targeting CDCP1 dimerization in triple-negative breast cancer. Cell Cycle. 2016 09 16; 15(18):2385-6. Wright HJ, Police AM, Razorenova OV. PMID: 27362899; PMCID: PMC5026807.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption. J Biomed Opt. 2016 06 01; 21(6):60503. Hou J, Wright HJ, Chan N, Tran R, Razorenova OV, Potma EO, Tromberg BJ. PMID: 27300321; PMCID: PMC4906146.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    13. CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene. 2016 09 08; 35(36):4762-72. Wright HJ, Arulmoli J, Motazedi M, Nelson LJ, Heinemann FS, Flanagan LA, Razorenova OV. PMID: 26876198; PMCID: PMC4985505.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    14. Approaches to identifying synthetic lethal interactions in cancer. Yale J Biol Med. 2015 Jun; 88(2):145-55. Thompson JM, Nguyen QH, Singh M, Razorenova OV. PMID: 26029013; PMCID: PMC4445436.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    15. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol. 2014 Feb; 34(4):739-51. Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. PMID: 24344197; PMCID: PMC3911479.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Res. 2012 Apr 15; 72(8):2111-9. Chernikova SB, Razorenova OV, Higgins JP, Sishc BJ, Nicolau M, Dorth JA, Chernikova DA, Kwok S, Brooks JD, Bailey SM, Game JC, Brown JM. PMID: 22354749; PMCID: PMC3328627.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    17. Brain and muscle ARNT-like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to hypoxia-inducible factor-mediated pathway. Cell Cycle. 2012 Jan 15; 11(2):213-4. Razorenova OV. PMID: 22223094.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    18. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1931-6. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. PMID: 21233420; PMCID: PMC3033256.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    19. Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells. Radiat Res. 2010 Nov; 174(5):558-65. Chernikova SB, Dorth JA, Razorenova OV, Game JC, Brown JM. PMID: 20738173; PMCID: PMC2988074.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    20. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature. 2010 Jul 01; 466(7302):133-7. Boiko AD, Razorenova OV, van de Rijn M, Swetter SM, Johnson DL, Ly DP, Butler PD, Yang GP, Joshua B, Kaplan MJ, Longaker MT, Weissman IL. PMID: 20596026; PMCID: PMC2898751.
      View in: PubMed   Mentions: 352     Fields:    Translation:HumansAnimalsCells
    21. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010 Jan; 30(1):344-53. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. PMID: 19858293; PMCID: PMC2798291.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    22. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med. 2009 Mar; 15(3):313-8. Malinin NL, Zhang L, Choi J, Ciocea A, Razorenova O, Ma YQ, Podrez EA, Tosi M, Lennon DP, Caplan AI, Shurin SB, Plow EF, Byzova TV. PMID: 19234460; PMCID: PMC2857384.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCells
    23. Integrin affinity modulation in angiogenesis. Cell Cycle. 2008 Feb 01; 7(3):335-47. Mahabeleshwar GH, Chen J, Feng W, Somanath PR, Razorenova OV, Byzova TV. PMID: 18287811; PMCID: PMC2677212.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    24. Akt1 in endothelial cell and angiogenesis. Cell Cycle. 2006 Mar; 5(5):512-8. Somanath PR, Razorenova OV, Chen J, Byzova TV. PMID: 16552185; PMCID: PMC1569947.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    25. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev. 2006 Jan 15; 20(2):236-52. Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. PMID: 16418486; PMCID: PMC1356114.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    26. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med. 2005 Nov; 11(11):1188-96. Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV. PMID: 16227992; PMCID: PMC2277080.
      View in: PubMed   Mentions: 220     Fields:    Translation:Animals
    27. VEGF-integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7589-94. De S, Razorenova O, McCabe NP, O'Toole T, Qin J, Byzova TV. PMID: 15897451; PMCID: PMC1129024.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    28. Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1. Gene. 2005 Apr 25; 350(1):89-98. Razorenova OV, Ivanov AV, Budanov AV, Chumakov PM. PMID: 15794924; PMCID: PMC2773277.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 2005 Jul; 19(9):1158-60. Narizhneva NV, Razorenova OV, Podrez EA, Chen J, Chandrasekharan UM, DiCorleto PE, Plow EF, Topol EJ, Byzova TV. PMID: 15833768; PMCID: PMC1569946.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    30. [Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors]. Mol Biol (Mosk). 2005 Mar-Apr; 39(2):286-93. Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM. PMID: 15856952; PMCID: PMC2774898.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    31. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res. 2004 Mar 15; 64(6):1951-8. Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV. PMID: 15026329.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    32. [Mobile genetic element MDG4 (gypsy) in Drosophila melanogaster. Features of structure and regulation of transposition]. Genetika. 2001 Dec; 37(12):1589-97. Kusulidu LK, Karpova NN, Razorenova OV, Glukhov IA, Kim AI, Liubomirskaia NV, Il'in IuV. PMID: 11785284.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. Two variants of the Drosophila melanogaster retrotransposon gypsy (mdg4): structural and functional differences, and distribution in fly stocks. Mol Genet Genomics. 2001 Apr; 265(2):367-74. Lyubomirskaya NV, Smirnova JB, Razorenova OV, Karpova NN, Surkov SA, Avedisov SN, Kim AI, Ilyin YV. PMID: 11361349.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. [Interlineage distribution and characteristics of the structure of two subfamilies of Drosophila melanogaster MDG4 (gypsy) retrotransposon]. Genetika. 2001 Feb; 37(2):175-82. Razorenova OV, Karpova NN, Smirnova IuB, Kusulidu LK, Reneva NK, Subocheva EA, Kim AI, Liubomirskaia NV, Il'in IuV. PMID: 11253423.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. [Genomic factors regulating the transposition of drosophila mobile elements]. Genetika. 1999 Nov; 35(11):1511-21. Kim AI, Pasiukova EG, Karpova NN, Razorenova OV. PMID: 10624574.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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