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Levin, Ellis R

TitleProfessor In Residence
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(562) 826-5748
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    Collapse Research 
    Collapse Research Activities and Funding
    Estrogen Receptor and Cardiovascular Function
    VA I01BX002316Apr 1, 2014 - Mar 31, 2018
    Role: Principal Investigator
    Estrogen Receptor and Cardiovascular Function
    VA I01BX000587Apr 1, 2010 - Mar 31, 2014
    Role: Principal Investigator
    Non-genomic actions of estrogen in breast cancer
    NIH/NCI R01CA100366Apr 1, 2003 - May 31, 2015
    Role: Principal Investigator
    NATRIURETIC PEPTIDE INHIBITS VEGF SYNTHESIS AND ACTIONS
    NIH/NHLBI R01HL059890Aug 1, 1999 - Jul 31, 2004
    Role: Principal Investigator
    ASTROCYTE PROLIFERATION--A NOVEL PATHWAY
    NIH/NINDS R01NS030521Jan 1, 1995 - Jun 30, 1999
    Role: Principal Investigator
    HYPERINSULINEMIA STIMULATES ENDOTHELIN PRODUCTION
    NIH/NHLBI R01HL050161May 1, 1993 - Apr 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Allard C, Morford JJ, Xu B, Salwen B, Xu W, Desmoulins L, Zsombok A, Kim JK, Levin ER, Mauvais-Jarvis F. Loss of Nuclear and Membrane Estrogen Receptor-a Differentially Impairs Insulin Secretion and Action in Male and Female Mice. Diabetes. 2018 Oct 10. PMID: 30305367.
      View in: PubMed
    2. Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F. Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes. Cell Rep. 2018 Jul 03; 24(1):181-196. PMID: 29972779.
      View in: PubMed
    3. Levin ER. Membrane estrogen receptors signal to determine transcription factor function. Steroids. 2018 Apr; 132:1-4. PMID: 29155215.
      View in: PubMed
    4. Hoa N, Ge L, Korach KS, Levin ER. Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Mol Cell Endocrinol. 2017 Nov 07. PMID: 29127073.
      View in: PubMed
    5. Levin ER, Hammes SR. Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors. Nat Rev Mol Cell Biol. 2016 12; 17(12):783-797. PMID: 27729652.
      View in: PubMed
    6. Pedram A, Razandi M, Narayanan R, Levin ER. Estrogen receptor beta signals to inhibition of cardiac fibrosis. Mol Cell Endocrinol. 2016 10 15; 434:57-68. PMID: 27321970.
      View in: PubMed
    7. Nanjappa MK, Hess RA, Medrano TI, Locker SH, Levin ER, Cooke PS. Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice. Endocrinology. 2016 07; 157(7):2909-19. PMID: 27145009.
      View in: PubMed
    8. Maric-Bilkan C, Arnold AP, Taylor DA, Dwinell M, Howlett SE, Wenger N, Reckelhoff JF, Sandberg K, Churchill G, Levin E, Lundberg MS. Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease: Scientific Questions and Challenges. Hypertension. 2016 May; 67(5):802-7. PMID: 26975706.
      View in: PubMed
    9. Pedram A, Razandi M, Blumberg B, Levin ER. Membrane and nuclear estrogen receptor a collaborate to suppress adipogenesis but not triglyceride content. FASEB J. 2016 Jan; 30(1):230-40. PMID: 26373802; PMCID: PMC4684544 [Available on 01/01/17].
    10. Levin ER. Extranuclear steroid receptors are essential for steroid hormone actions. Annu Rev Med. 2015; 66:271-80. PMID: 25587652.
      View in: PubMed
    11. Levin ER. Extranuclear estrogen receptor's roles in physiology: lessons from mouse models. Am J Physiol Endocrinol Metab. 2014 Jul 15; 307(2):E133-40. PMID: 24895281; PMCID: PMC4101634.
    12. Pedram A, Razandi M, Lewis M, Hammes S, Levin ER. Membrane-localized estrogen receptor a is required for normal organ development and function. Dev Cell. 2014 May 27; 29(4):482-90. PMID: 24871949; PMCID: PMC4062189.
    13. Levin ER. Translating extranuclear steroid receptor signaling to clinical medicine. Horm Cancer. 2014 Jun; 5(3):140-5. PMID: 24752388; PMCID: PMC4040225.
    14. Pedram A, Razandi M, Narayanan R, Dalton JT, McKinsey TA, Levin ER. Estrogen regulates histone deacetylases to prevent cardiac hypertrophy. Mol Biol Cell. 2013 Dec; 24(24):3805-18. PMID: 24152730; PMCID: PMC3861078.
    15. Cho SK, Pedram A, Levin ER, Kwon YJ. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials. 2013 Dec; 34(38):10228-37. PMID: 24055523; PMCID: PMC3989112.
    16. Pedram A, Razandi M, Korach KS, Narayanan R, Dalton JT, Levin ER. ERß selective agonist inhibits angiotensin-induced cardiovascular pathology in female mice. Endocrinology. 2013 Nov; 154(11):4352-64. PMID: 23970786.
      View in: PubMed
    17. Pedram A, Razandi M, O'Mahony F, Harvey H, Harvey BJ, Levin ER. Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling. Sci Signal. 2013 May 21; 6(276):ra36. PMID: 23695162.
      View in: PubMed
    18. O'Mahony F, Razandi M, Pedram A, Harvey BJ, Levin ER. Estrogen modulates metabolic pathway adaptation to available glucose in breast cancer cells. Mol Endocrinol. 2012 Dec; 26(12):2058-70. PMID: 23028062; PMCID: PMC3517720.
    19. Simpkins F, Hevia-Paez P, Sun J, Ullmer W, Gilbert CA, da Silva T, Pedram A, Levin ER, Reis IM, Rabinovich B, Azzam D, Xu XX, Ince TA, Yang JY, Verhaak RG, Lu Y, Mills GB, Slingerland JM. Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res. 2012 Nov 01; 18(21):5911-23. PMID: 22896656; PMCID: PMC3698880.
    20. Levin ER. Elusive extranuclear estrogen receptors in breast cancer. Clin Cancer Res. 2012 Jan 01; 18(1):6-8. PMID: 22215901; PMCID: PMC3257555.
    21. Pedram A, Razandi M, Deschenes RJ, Levin ER. DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. Mol Biol Cell. 2012 Jan; 23(1):188-99. PMID: 22031296; PMCID: PMC3248897.
    22. Hammes SR, Levin ER. Minireview: Recent advances in extranuclear steroid receptor actions. Endocrinology. 2011 Dec; 152(12):4489-95. PMID: 22028449; PMCID: PMC3858720.
    23. Levin ER. Minireview: Extranuclear steroid receptors: roles in modulation of cell functions. Mol Endocrinol. 2011 Mar; 25(3):377-84. PMID: 20861220; PMCID: PMC3045744.
    24. Pedram A, Razandi M, O'Mahony F, Lubahn D, Levin ER. Estrogen receptor-beta prevents cardiac fibrosis. Mol Endocrinol. 2010 Nov; 24(11):2152-65. PMID: 20810711; PMCID: PMC2958752.
    25. Razandi M, Pedram A, Levin ER. Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane. Mol Cell Biol. 2010 Jul; 30(13):3249-61. PMID: 20439495; PMCID: PMC2897588.
    26. Levin ER. Plasma membrane estrogen receptors. Trends Endocrinol Metab. 2009 Dec; 20(10):477-82. PMID: 19783454; PMCID: PMC3589572.
    27. Levin ER. Membrane oestrogen receptor alpha signalling to cell functions. J Physiol. 2009 Nov 01; 587(Pt 21):5019-23. PMID: 19687123; PMCID: PMC2790244.
    28. Pedram A, Razandi M, Evinger AJ, Lee E, Levin ER. Estrogen inhibits ATR signaling to cell cycle checkpoints and DNA repair. Mol Biol Cell. 2009 Jul; 20(14):3374-89. PMID: 19477925; PMCID: PMC2710824.
    29. Levin ER. G protein-coupled receptor 30: estrogen receptor or collaborator? Endocrinology. 2009 Apr; 150(4):1563-5. PMID: 19307418; PMCID: PMC2659267.
    30. Levin ER. Hormone action and breast cancer. Cancer Treat Res. 2009; 147:1-10. PMID: 21461829.
      View in: PubMed
    31. Pedram A, Razandi M, Kim JK, O'Mahony F, Lee EY, Luderer U, Levin ER. Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse. J Biol Chem. 2009 Feb 06; 284(6):3488-95. PMID: 19054762; PMCID: PMC2635032.
    32. Levin ER. Rapid signaling by steroid receptors. Am J Physiol Regul Integr Comp Physiol. 2008 Nov; 295(5):R1425-30. PMID: 18784332; PMCID: PMC2584866.
    33. Pedram A, Razandi M, Lubahn D, Liu J, Vannan M, Levin ER. Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin. Endocrinology. 2008 Jul; 149(7):3361-9. PMID: 18372323; PMCID: PMC2453079.
    34. Hammes SR, Levin ER. Extranuclear steroid receptors: nature and actions. Endocr Rev. 2007 Dec; 28(7):726-41. PMID: 17916740.
      View in: PubMed
    35. Levin ER, Pietras RJ. Estrogen receptors outside the nucleus in breast cancer. Breast Cancer Res Treat. 2008 Apr; 108(3):351-61. PMID: 17592774.
      View in: PubMed
    36. Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem. 2007 Aug 03; 282(31):22278-88. PMID: 17535799.
      View in: PubMed
    37. Kim JK, Levin ER. Estrogen signaling in the cardiovascular system. Nucl Recept Signal. 2006; 4:e013. PMID: 16862219; PMCID: PMC1513067.
    38. Pedram A, Razandi M, Levin ER. Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol. 2006 Sep; 20(9):1996-2009. PMID: 16645038.
      View in: PubMed
    39. Pedram A, Razandi M, Wallace DC, Levin ER. Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell. 2006 May; 17(5):2125-37. PMID: 16495339; PMCID: PMC1446071.
    40. Kim JK, Pedram A, Razandi M, Levin ER. Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem. 2006 Mar 10; 281(10):6760-7. PMID: 16407188.
      View in: PubMed
    41. Guo X, Lu X, Ren H, Levin ER, Kassab GS. Estrogen modulates the mechanical homeostasis of mouse arterial vessels through nitric oxide. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1788-97. PMID: 16306215.
      View in: PubMed
    42. Pietras RJ, Levin ER, Szego CM. Estrogen receptors and cell signaling. Science. 2005 Oct 07; 310(5745):51-3; author reply 51-3. PMID: 16210518.
      View in: PubMed
    43. Pedram A, Razandi M, Aitkenhead M, Levin ER. Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1. J Biol Chem. 2005 Jul 15; 280(28):26339-48. PMID: 15899894; PMCID: PMC1249515.
    44. Evinger AJ, Levin ER. Requirements for estrogen receptor alpha membrane localization and function. Steroids. 2005 May-Jun; 70(5-7):361-3. PMID: 15862818.
      View in: PubMed
    45. Guo X, Razandi M, Pedram A, Kassab G, Levin ER. Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta. J Biol Chem. 2005 May 20; 280(20):19704-10. PMID: 15764600.
      View in: PubMed
    46. Levin ER. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol. 2005 Aug; 19(8):1951-9. PMID: 15705661; PMCID: PMC1249516.
    47. Razandi M, Pedram A, Rosen EM, Levin ER. BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol. 2004 Jul; 24(13):5900-13. PMID: 15199145; PMCID: PMC480898.
    48. Razandi M, Pedram A, Merchenthaler I, Greene GL, Levin ER. Plasma membrane estrogen receptors exist and functions as dimers. Mol Endocrinol. 2004 Dec; 18(12):2854-65. PMID: 15231873.
      View in: PubMed
    49. Razandi M, Alton G, Pedram A, Ghonshani S, Webb P, Levin ER. Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane. Mol Cell Biol. 2003 Mar; 23(5):1633-46. PMID: 12588983; PMCID: PMC151696.
    50. Levin ER. Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor. Mol Endocrinol. 2003 Mar; 17(3):309-17. PMID: 12554774.
      View in: PubMed
    51. Razandi M, Pedram A, Park ST, Levin ER. Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem. 2003 Jan 24; 278(4):2701-12. PMID: 12421825.
      View in: PubMed
    52. Pedram A, Razandi M, Aitkenhead M, Hughes CC, Levin ER. Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem. 2002 Dec 27; 277(52):50768-75. PMID: 12372818.
      View in: PubMed
    53. Pedram A, Razandi M, Levin ER. Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. J Biol Chem. 2002 Nov 15; 277(46):44385-98. PMID: 12213803.
      View in: PubMed
    54. Levin ER. Estrogen receptor-beta and the cardiovascular system. Trends Endocrinol Metab. 2002 Jul; 13(5):184-5. PMID: 12185660.
      View in: PubMed
    55. Levin ER. Cellular functions of plasma membrane estrogen receptors. Steroids. 2002 May; 67(6):471-5. PMID: 11960623.
      View in: PubMed
    56. Razandi M, Oh P, Pedram A, Schnitzer J, Levin ER. ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol Endocrinol. 2002 Jan; 16(1):100-15. PMID: 11773442.
      View in: PubMed