Jin, Rongsheng

InstitutionUniversity of California, Irvine
DepartmentPhysiology and Biophysics
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-6580
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    Collapse Research 
    Collapse Research Activities and Funding
    Computational design of inhibitors against botulinum neurotoxin
    NIH/NIAID R21AI139690Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    Structure and Function of C. Difficile Toxins
    NIH/NIAID R01AI139087May 15, 2018 - Apr 30, 2023
    Role: Co-Principal Investigator
    Molecular mechanisms of botulinum neurotoxin neutralization
    NIH/NIAID R01AI125704May 10, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Structural mechanism for recognition of host receptor by botulinum neurotoxin A
    NIH/NIAID R21AI123920Mar 7, 2016 - Feb 28, 2018
    Role: Principal Investigator
    Mechanisms of neuromuscular junction formation
    NIH/NINDS R01NS082007Jun 1, 2013 - Jun 30, 2023
    Role: Co-Principal Investigator
    Structural and functional studies of botulinum neurotoxin
    NIH/NIAID R01AI091823Dec 15, 2011 - Nov 30, 2016
    Role: Principal Investigator
    The amino-terminal domain guides subfamily-specific assembly of ionotropic glutam
    NIH/NIGMS R01GM090023Jun 1, 2010 - May 31, 2015
    Role: Principal Investigator
    Mechanism of Allosteric Modulator Action at the Ionotropic Glutamate Receptor
    NIH/NIA R21AG033813Aug 15, 2009 - Jan 31, 2012
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R. Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science. 2018 05 11; 360(6389):664-669. PMID: 29748286.
      View in: PubMed
    2. Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R. Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA. Pathog Dis. 2018 Apr 23. PMID: 29688327.
      View in: PubMed
    3. Lam KH, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R. The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon. 2018 Jun 01; 147:19-26. PMID: 29042313.
      View in: PubMed
    4. Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R. A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. Sci Rep. 2017 Aug 07; 7(1):7438. PMID: 28785006.
      View in: PubMed
    5. Yao G, Lam KH, Perry K, Weisemann J, Rummel A, Jin R. Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel). 2017 03 08; 9(3). PMID: 28282873.
      View in: PubMed
    6. Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 2016 07; 23(7):656-62. PMID: 27294781; PMCID: PMC5033645 [Available on 12/13/16].
    7. Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R. Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics. Toxicon. 2015 Dec 01; 107(Pt A):43-9. PMID: 26272706; PMCID: PMC4658216 [Available on 12/01/16].
    8. Lam KH, Jin R. Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery. Curr Opin Struct Biol. 2015 Apr; 31:89-95. PMID: 25889616; PMCID: PMC4476938.
    9. Lam KH, Yao G, Jin R. Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin. Prog Biophys Mol Biol. 2015 Mar; 117(2-3):225-231. PMID: 25701633.
      View in: PubMed
    10. Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 2014 Jun 20; 344(6190):1405-10. PMID: 24948737; PMCID: PMC4164303.
    11. Lee K, Lam KH, Kruel AM, Perry K, Rummel A, Jin R. High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex. Biochem Biophys Res Commun. 2014 Apr 04; 446(2):568-73. PMID: 24631690; PMCID: PMC4020412.
    12. Yao G, Lee K, Gu S, Lam KH, Jin R. Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component. Toxins (Basel). 2014 Feb 12; 6(2):624-35. PMID: 24525478; PMCID: PMC3942755.
    13. Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathog. 2013; 9(10):e1003690. PMID: 24130488; PMCID: PMC3795040.
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