Rongsheng Jin

Title(s)Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6580
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    Collapse Research 
    Collapse Research Activities and Funding
    Structural basis for recognition of SV2 by type E botulinum neurotoxin
    NIH R21AI163178Jul 9, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Developing broad-spectrum therapeutics against C. difficile toxins
    NIH R01AI158503Feb 11, 2021 - Jan 31, 2026
    Role: Principal Investigator
    Structural basis of Rho glucosylation by Clostridium difficile toxins
    NIH R21AI156092Dec 1, 2020 - Nov 30, 2022
    Role: Principal Investigator
    Novel anti-cancer biologics targeting Wnt signaling pathway
    NIH R21CA235533Dec 7, 2018 - Nov 30, 2020
    Role: Co-Principal Investigator
    Computational design of inhibitors against botulinum neurotoxin
    NIH R21AI139690Jun 1, 2018 - May 31, 2021
    Role: Principal Investigator
    Structure and Function of C. Difficile Toxins
    NIH R01AI139087May 15, 2018 - Apr 30, 2023
    Role: Co-Principal Investigator
    Molecular mechanisms of botulinum neurotoxin neutralization
    NIH R01AI125704May 10, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Structural mechanism for recognition of host receptor by botulinum neurotoxin A
    NIH R21AI123920Mar 7, 2016 - Feb 28, 2019
    Role: Principal Investigator
    Mechanisms of neuromuscular junction formation
    NIH R01NS082007Jun 1, 2013 - Jun 30, 2023
    Role: Co-Principal Investigator
    Structural and functional studies of botulinum neurotoxin
    NIH R01AI091823Dec 15, 2011 - Nov 30, 2017
    Role: Principal Investigator
    The amino-terminal domain guides subfamily-specific assembly of ionotropic glutam
    NIH R01GM090023Jun 1, 2010 - May 31, 2016
    Role: Principal Investigator
    Mechanism of Allosteric Modulator Action at the Ionotropic Glutamate Receptor
    NIH R21AG033813Aug 15, 2009 - Jan 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NTNH protein: more than a bodyguard for botulinum neurotoxins. FEBS J. 2024 Feb; 291(4):672-675. Gao L, Jin R. PMID: 38009421; PMCID: PMC10922118.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun. 2023 04 24; 14(1):2338. Liu Z, Lee PG, Krez N, Lam KH, Liu H, Przykopanski A, Chen P, Yao G, Zhang S, Tremblay JM, Perry K, Shoemaker CB, Rummel A, Dong M, Jin R. PMID: 37095076; PMCID: PMC10125960.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    3. Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1. FEBS Lett. 2023 02; 597(4):524-537. Gao L, Lam KH, Liu S, Przykopanski A, Lübke J, Qi R, Krüger M, Nowakowska MB, Selby K, Douillard FP, Dorner MB, Perry K, Lindström M, Dorner BG, Rummel A, Jin R. PMID: 36653893; PMCID: PMC10019085.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies. Front Immunol. 2022; 13:978858. Chen B, Perry K, Jin R. PMID: 36466927; PMCID: PMC9709291.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition. Sci Rep. 2022 05 30; 12(1):9028. Chen B, Liu Z, Perry K, Jin R. PMID: 35637242; PMCID: PMC9151644.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 04 05; 39(1):110641. Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. PMID: 35385746; PMCID: PMC9127750.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Structure and conformational dynamics of Clostridioides difficile toxin A. Life Sci Alliance. 2022 06; 5(6). Chen B, Basak S, Chen P, Zhang C, Perry K, Tian S, Yu C, Dong M, Huang L, Bowen ME, Jin R. PMID: 35292538; PMCID: PMC8924006.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    8. Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. PLoS Pathog. 2022 01; 18(1):e1010169. Lam KH, Tremblay JM, Perry K, Ichtchenko K, Shoemaker CB, Jin R. PMID: 34990480; PMCID: PMC8769338.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development. FEBS J. 2023 02; 290(4):962-969. Chen P, Jin R. PMID: 34862749; PMCID: PMC9344982.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    10. Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B. Sci Adv. 2021 Oct 22; 7(43):eabi4582. Liu Z, Zhang S, Chen P, Tian S, Zeng J, Perry K, Dong M, Jin R. PMID: 34678063; PMCID: PMC8535798.
      View in: PubMed   Mentions: 8     Fields:    
    11. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nat Commun. 2021 06 18; 12(1):3748. Chen P, Zeng J, Liu Z, Thaker H, Wang S, Tian S, Zhang J, Tao L, Gutierrez CB, Xing L, Gerhard R, Huang L, Dong M, Jin R. PMID: 34145250; PMCID: PMC8213806.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    12. Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells. Toxins (Basel). 2020 09 27; 12(10). Lam KH, Perry K, Shoemaker CB, Jin R. PMID: 32992561; PMCID: PMC7599855.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    13. Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. Cell Rep. 2020 02 25; 30(8):2526-2539.e6. Lam KH, Tremblay JM, Vazquez-Cintron E, Perry K, Ondeck C, Webb RP, McNutt PM, Shoemaker CB, Jin R. PMID: 32101733; PMCID: PMC7138525.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    14. Structure of the full-length Clostridium difficile toxin B. Nat Struct Mol Biol. 2019 08; 26(8):712-719. Chen P, Lam KH, Liu Z, Mindlin FA, Chen B, Gutierrez CB, Huang L, Zhang Y, Hamza T, Feng H, Matsui T, Bowen ME, Perry K, Jin R. PMID: 31308519; PMCID: PMC6684407.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    15. A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1. Nat Commun. 2018 12 18; 9(1):5367. Lam KH, Guo Z, Krez N, Matsui T, Perry K, Weisemann J, Rummel A, Bowen ME, Jin R. PMID: 30560862; PMCID: PMC6299077.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    16. Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B. FEBS J. 2019 03; 286(5):874-881. Chen P, Tao L, Liu Z, Dong M, Jin R. PMID: 30347517; PMCID: PMC6399045.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    17. Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA. Pathog Dis. 2018 06 01; 76(4). Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R. PMID: 29688327; PMCID: PMC5961070.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    18. Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science. 2018 05 11; 360(6389):664-669. Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin R. PMID: 29748286; PMCID: PMC6231499.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    19. The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon. 2018 Jun 01; 147:19-26. Lam KH, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R. PMID: 29042313; PMCID: PMC5902665.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    20. A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. Sci Rep. 2017 08 07; 7(1):7438. Yao G, Lam KH, Weisemann J, Peng L, Krez N, Perry K, Shoemaker CB, Dong M, Rummel A, Jin R. PMID: 28785006; PMCID: PMC5547058.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    21. Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel). 2017 03 08; 9(3). Yao G, Lam KH, Perry K, Weisemann J, Rummel A, Jin R. PMID: 28282873; PMCID: PMC5371848.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    22. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 2016 07; 23(7):656-62. Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R. PMID: 27294781; PMCID: PMC5033645.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    23. Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics. Toxicon. 2015 Dec 01; 107(Pt A):43-9. Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R. PMID: 26272706; PMCID: PMC4658216.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    24. Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery. Curr Opin Struct Biol. 2015 Apr; 31:89-95. Lam KH, Jin R. PMID: 25889616; PMCID: PMC4476938.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    25. Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin. Prog Biophys Mol Biol. 2015 Mar; 117(2-3):225-231. Lam KH, Yao G, Jin R. PMID: 25701633; PMCID: PMC4417461.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    26. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 2014 Jun 20; 344(6190):1405-10. Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R. PMID: 24948737; PMCID: PMC4164303.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    27. High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex. Biochem Biophys Res Commun. 2014 Apr 04; 446(2):568-73. Lee K, Lam KH, Kruel AM, Perry K, Rummel A, Jin R. PMID: 24631690; PMCID: PMC4020412.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    28. Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component. Toxins (Basel). 2014 Feb 12; 6(2):624-35. Yao G, Lee K, Gu S, Lam KH, Jin R. PMID: 24525478; PMCID: PMC3942755.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathog. 2013; 9(10):e1003690. Lee K, Gu S, Jin L, Le TT, Cheng LW, Strotmeier J, Kruel AM, Yao G, Perry K, Rummel A, Jin R. PMID: 24130488; PMCID: PMC3795040.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
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