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Maheswari Senthil

Title(s)Health Sciences Professor, Surgery
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Peritoneal carcinomatosis in gastric cancer: Are Hispanics at higher risk? J Surg Oncol. 2020 Sep 09. Choi AH, Ji L, Babcock B, Ramos V, Kwong MLM, Morgan JW, Selleck MJ, Langridge WHR, DeLeon M, Wall NR, Lum S, Pigazzi A, Dayyani F, Senthil M. PMID: 32901938.
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    2. ASO Author Reflections: Real-World Incidence of Peritoneal Carcinomatosis After Colon Cancer Resection and Why It Matters. Ann Surg Oncol. 2020 Jul 06. Choi AH, Senthil M. PMID: 32627117.
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    3. Rate of Peritoneal Carcinomatosis in Resected Stage II and III Colon Cancer. Ann Surg Oncol. 2020 Jun 14. Choi AH, Farzaneh C, Kejriwal N, Calidas A, Cordero-Caban K, Roman M, Kwong MLM, Selleck MJ, Pigazzi A, Jafari D, Senthil M. PMID: 32535867.
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    4. The Impact of Primary Tumor Surgery on Survival in HER2 Positive Stage IV Breast Cancer Patients in the Current Era of Targeted Therapy. Ann Surg Oncol. 2020 Aug; 27(8):2711-2720. Mudgway R, Chavez de Paz Villanueva C, Lin AC, Senthil M, Garberoglio CA, Lum SS. PMID: 32157524.
      View in: PubMed   Mentions: 1     Fields:    
    5. From Evidence to Practice: Are Low-Risk Breast Cancer Patients still Enduring Unnecessary Costs of Radiation? Am Surg. 2019 Dec 01; 85(12):1414-1418. Thornhill R, Chang J, Selleck M, Senthil M, Solomon N, Namm JP, Garberoglio CA, Lum S. PMID: 31908229.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Response to Neoadjuvant Treatment Is Influenced by Grade in Gastric Cancer. Am Surg. 2019 Dec 01; 85(12):1419-1422. Kwong MLM, Denham L, Selleck MJ, Kim C, Kunihira K, Kubba R, Rojas R, Garberoglio C, Senthil M. PMID: 31908230.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Costs and Complications: Delayed Gastric Emptying after Pancreaticoduodenectomy. Am Surg. 2019 Dec 01; 85(12):1423-1428. Grossi S, Lin A, Wong A, Namm J, Senthil M, Gomez N, Reeves M, Garberoglio C, Solomon N. PMID: 31908231.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Improved Survival with Immunotherapy but Lack of Synergistic Effect with Radiation for Stage IV Melanoma of the Head and Neck. Am Surg. 2019 Oct 01; 85(10):1118-1124. Babcock B, Rodrigues M, Kearns D, Solomon N, Reeves ME, Senthil M, Garberoglio CA, Namm JP. PMID: 31657306.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Gastric Cancer Peritoneal Carcinomatosis Risk Score. Ann Surg Oncol. 2020 Jan; 27(1):240-247. Ji L, Selleck MJ, Morgan JW, Xu J, Babcock BD, Shavlik D, Wall NR, Langridge WH, Lum SS, Garberoglio CA, Reeves ME, Solomon N, Namm JP, Senthil M. PMID: 31346896.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Resection of Cavity Shave Margins in Stage 0-III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial. Ann Surg. 2019 Jul 08. Dupont E, Tsangaris T, Garcia-Cantu C, Howard-McNatt M, Chiba A, Berger AC, Levine EA, Gass JS, Gallagher K, Lum SS, Martinez RD, Willis AI, Pandya SV, Brown EA, Fenton A, Mendiola A, Murray M, Solomon NL, Senthil M, Ollila DW, Edmonson D, Lazar M, Namm JP, Li F, Butler M, McGowan NE, Herrera ME, Avitan YP, Yoder B, Walters LL, McPartland T, Chagpar AB. PMID: 31290763.
      View in: PubMed   Mentions:    Fields:    
    11. Concomitant KRAS and BRAF mutations in colorectal cancer. J Gastrointest Oncol. 2019 Jun; 10(3):577-581. Midthun L, Shaheen S, Deisch J, Senthil M, Tsai J, Hsueh CT. PMID: 31183211.
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    12. Factors Predictive of Outcomes after Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy for Colon and Appendiceal Carcinomatosis: A Single-Institution Experience. Am Surg. 2018 Oct 01; 84(10):1575-1579. Babcock B, Jabo B, Selleck M, Reeves M, Garberoglio C, Namm J, Kazanjian K, Senthil M. PMID: 30747672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Attending Surgeon Variation in Operative Case Length: An Opportunity for Quality Improvement. Am Surg. 2018 Oct 01; 84(10):1595-1599. Malek KS, Namm JP, Garberoglio CA, Senthil M, Solomon N, Reeves ME, Lum SS. PMID: 30747676.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Sexual and urinary outcomes in robotic rectal surgery: review of the literature and technical considerations. Updates Surg. 2018 Sep; 70(3):415-421. Luca F, Craigg DK, Senthil M, Selleck MJ, Babcock BD, Reeves ME, Garberoglio CA. PMID: 30120743.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Role of lymph node ratio in selection of adjuvant treatment (chemotherapy vs. chemoradiation) in patients with resected gastric cancer. J Gastrointest Oncol. 2018 Aug; 9(4):708-717. Jabo B, Selleck MJ, Morgan JW, Lum SS, Bahjri K, Aljehani M, Garberoglio CA, Reeves ME, Namm JP, Solomon NL, Luca F, Yang G, Senthil M. PMID: 30151267.
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    16. High-Risk Stage II Colon Cancer: Not All Risks Are Created Equal. Ann Surg Oncol. 2018 Jul; 25(7):1980-1985. Babcock BD, Aljehani MA, Jabo B, Choi AH, Morgan JW, Selleck MJ, Luca F, Raskin E, Reeves ME, Garberoglio CA, Lum SS, Senthil M. PMID: 29675762.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Comparison of perioperative chemotherapy with adjuvant chemoradiotherapy for resectable gastric cancer: findings from a population-based study. J Gastrointest Oncol. 2018 Feb; 9(1):35-45. Jabo B, Selleck MJ, Morgan JW, Lum SS, Bahjri KA, Aljehani M, Garberoglio CA, Reeves ME, Namm JP, Solomon NL, Luca F, Dyke C, Senthil M. PMID: 29564169.
      View in: PubMed   Mentions:
    18. Association of Primary Tumor Site With Mortality in Patients Receiving Bevacizumab and Cetuximab for Metastatic Colorectal Cancer. JAMA Surg. 2018 01 01; 153(1):60-67. Aljehani MA, Morgan JW, Guthrie LA, Jabo B, Ramadan M, Bahjri K, Lum SS, Selleck M, Reeves ME, Garberoglio C, Senthil M. PMID: 28975237.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Erratum to: Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)? Ann Surg Oncol. 2017 12; 24(Suppl 3):690. Whealon MD, Gahagan JV, Sujatha-Bhaskar S, O'Leary MP, Selleck M, Dumitra S, Lee B, Senthil M, Pigazzi A. PMID: 28547561.
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    20. Benefit of Surgical Resection of the Primary Tumor in Patients Undergoing Chemotherapy for Stage IV Colorectal Cancer with Unresected Metastasis. J Gastrointest Surg. 2018 03; 22(3):460-466. Maroney S, de Paz CC, Reeves ME, Garberoglio C, Raskin E, Senthil M, Namm JP, Solomon N. PMID: 29124549.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Factors Associated With Underestimation of Invasive Cancer in Patients With Ductal Carcinoma In Situ: Precautions for Active Surveillance. JAMA Surg. 2017 Nov 01; 152(11):1007-1014. Chavez de Paz Villanueva C, Bonev V, Senthil M, Solomon N, Reeves ME, Garberoglio CA, Namm JP, Lum SS. PMID: 28700803.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Peritoneal carcinomatosis: limits of diagnosis and the case for liquid biopsy. Oncotarget. 2017 Jun 27; 8(26):43481-43490. McMullen JRW, Selleck M, Wall NR, Senthil M. PMID: 28415645.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    23. Making Meaningful Clinical Use of Biomarkers. Biomark Insights. 2017; 12:1177271917715236. Selleck MJ, Senthil M, Wall NR. PMID: 28659713.
      View in: PubMed   Mentions:
    24. Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)? Ann Surg Oncol. 2017 Aug; 24(8):2122-2128. Whealon MD, Gahagan JV, Sujatha-Bhaskar S, O'Leary MP, Selleck M, Dumitra S, Lee B, Senthil M, Pigazzi A. PMID: 28411306.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Outcomes of Nipple-Sparing Mastectomy: Role of Anatomic Measurements. Am Surg. 2016 Oct; 82(10):944-948. Pairawan SS, Cody D, Kim H, Hughes MK, Solomon N, Senthil M, Garberoglio C, Lum S. PMID: 27779979.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Is Sentinel Lymph Node Dissection Necessary in All Patients with Ductal Carcinoma In Situ Undergoing Total Mastectomy? Am Surg. 2016 Oct; 82(10):982-984. Bonev V, De Paz Villanueva CC, Solomon N, Senthil M, Reeves ME, Garberoglio C, Lum SS. PMID: 27779988.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Percutaneous Sentinel Node Biopsy in Breast Cancer: Results of a Phase 1 Study. Ann Surg Oncol. 2016 10; 23(10):3330-6. Pairawan SS, Cora C, Olaya W, Deisch J, Garberoglio R, Solomon N, Senthil M, Garberoglio C, Lum SS. PMID: 27334213.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    28. Implications of abnormal preoperative axillary imaging in the post Z011 era. Gland Surg. 2016 Jun; 5(3):372-4. Selleck M, Senthil M. PMID: 27294255.
      View in: PubMed   Mentions:
    29. Size of Extranodal Extension on Sentinel Lymph Node Dissection in the American College of Surgeons Oncology Group Z0011 Trial Era. JAMA Surg. 2015 Dec; 150(12):1141-8. Choi AH, Blount S, Perez MN, Chavez de Paz CE, Rodriguez SA, Surrusco M, Garberoglio CA, Lum SS, Senthil M. PMID: 26331347.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    30. The Effect of Breast Implants on Mammogram Outcomes. Am Surg. 2015 Oct; 81(10):1053-6. Kam K, Lee E, Pairawan S, Anderson K, Cora C, Bae W, Senthil M, Solomon N, Lum S. PMID: 26463307.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    31. Initial Results of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer and Lynch Syndrome. Am Surg. 2015 Oct; 81(10):941-4. Howarth DR, Lum SS, Esquivel P, Garberoglio CA, Senthil M, Solomon NL. PMID: 26463285.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells. Chem Res Toxicol. 2015 May 18; 28(5):855-71. McLean LS, Watkins CN, Campbell P, Zylstra D, Rowland L, Amis LH, Scott L, Babb CE, Livingston WJ, Darwanto A, Davis WL, Senthil M, Sowers LC, Brantley E. PMID: 25781201.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. The role of the cancer center when using lymph node count as a quality measure for gastric cancer surgery. JAMA Surg. 2015 Jan; 150(1):37-43. Morgan JW, Ji L, Friedman G, Senthil M, Dyke C, Lum SS. PMID: 25426671.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    34. Extranodal extension on sentinel lymph node dissection: why should we treat it differently? Am Surg. 2014 Oct; 80(10):932-5. Choi AH, Surrusco M, Rodriguez S, Bahjri K, Solomon N, Garberoglio C, Lum S, Senthil M. PMID: 25264632.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol. 2014 Dec; 110(7):779-85. Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. PMID: 25088304.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    36. The American Society of Peritoneal Surface Malignancies (ASPSM) Multiinstitution Evaluation of the Peritoneal Surface Disease Severity Score (PSDSS) in 1,013 Patients with Colorectal Cancer with Peritoneal Carcinomatosis. Ann Surg Oncol. 2014 Dec; 21(13):4195-201. Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spilioitis J, Torres-Melero J, Turaga K, Trout R. PMID: 24854493.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    37. A shortened activated partial thromboplastin time predicts the risk of catheter-associated venous thrombosis in cancer patients. Thromb Res. 2014 Jul; 134(1):165-8. Senthil M, Chaudhary P, Smith DD, Ventura PE, Frankel PH, Pullarkat V, Trisal V. PMID: 24830901.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Surgical and radiation therapy management of recurrent anal melanoma. J Gastrointest Oncol. 2014 Feb; 5(1):E7-E12. Ling TC, Slater JM, Senthil M, Kazanjian K, Howard F, Garberoglio CA, Slater JD, Yang GY. PMID: 24490051.
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    39. Down-regulation of LXR/RXR activation and negative acute phase response pathways in colon adenocarcinoma revealed by proteomics and bioinformatics analysis. Cancer Biomark. 2014; 14(5):313-24. Tang H, Mirshahidi S, Senthil M, Kazanjian K, Chen CS, Zhang K. PMID: 25171473.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Rate of re-excision after breast-conserving surgery for invasive lobular carcinoma. Am Surg. 2013 Oct; 79(10):1119-22. Wanis ML, Wong JA, Rodriguez S, Wong JM, Jabo B, Ashok A, Lum SS, Solomon NL, Reeves ME, Garberoglio CA, Senthil M. PMID: 24160812.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    41. The prevalence of overweight and obesity in a breast clinic population: consideration for weight loss as a therapeutic intervention. Surg Obes Relat Dis. 2014 Mar-Apr; 10(2):348-53. Kim A, Scharf K, Senthil M, Solomon N, Garberoglio C, Lum SS. PMID: 24094868.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    42. Assessment of clinical benefit and quality of life in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of peritoneal carcinomatosis. J Gastrointest Oncol. 2013 Mar; 4(1):3-4. Senthil M. PMID: 23451328.
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    43. Postoperative management after hepatic resection. J Gastrointest Oncol. 2012 Mar; 3(1):41-7. Wrighton LJ, O'Bosky KR, Namm JP, Senthil M. PMID: 22811868.
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    44. Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression. Mol Cancer Ther. 2011 Oct; 10(10):1774-83. Gao J, Wang Y, Xing Q, Yan J, Senthil M, Akmal Y, Kowolik CM, Kang J, Lu DM, Zhao M, Lin Z, Cheng CH, Yip ML, Yim JH. PMID: 21817116.
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    45. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol. 2011 May 20; 6(5):432-43. Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, Moore R, Gugiu G, Lee TD, Yip R, Chen Y, Jove R, Horne D, Williams JC. PMID: 21226522.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    46. Intravenous injection of mesenteric lymph produced during hemorrhagic shock decreases RBC deformability in the rat. J Trauma. 2011 Feb; 70(2):489-95. Condon M, Senthil M, Xu DZ, Mason L, Sheth SU, Spolarics Z, Feketova E, Machiedo GW, Deitch EA. PMID: 21307751.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Transarterial radioembolization with Yttrium-90 for regional management of hepatocellular cancer: the early results of a nontransplant center. Am Surg. 2010 Oct; 76(10):1079-83. Holt A, Wagman LD, Senthil M, McKenzie S, Marx H, Chen YJ, Vora N, Kim J. PMID: 21105614.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Prediction of the adequacy of lymph node retrieval in colon cancer by hospital type. Arch Surg. 2010 Sep; 145(9):840-3. Senthil M, Trisal V, Paz IB, Lai LL. PMID: 20855753.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    49. Simultaneous bicavitary hyperthermic chemoperfusion in the management of pseudomyxoma peritonei with synchronous pleural extension. Arch Surg. 2009 Oct; 144(10):970-2. Senthil M, Harrison LE. PMID: 19841367.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    50. Disparities in gastric cancer outcomes among Asian ethnicities in the USA. Ann Surg Oncol. 2009 Sep; 16(9):2433-41. Kim J, Mailey B, Senthil M, Artinyan A, Sun CL, Bhatia S. PMID: 19582508.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    51. Mesenteric lymph duct ligation improves survival in a lethal shock model. Shock. 2008 Dec; 30(6):680-5. Badami CD, Senthil M, Caputo FJ, Rupani BJ, Doucet D, Pisarenko V, Xu DZ, Lu Q, Feinman R, Deitch EA. PMID: 18496238.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    52. Trauma-shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal porcine model. Shock. 2008 Aug; 30(2):135-41. Deitch EA, Senthil M, Brown M, Caputo F, Watkins A, Anjaria D, Badami C, Pisarenko V, Doucet D, Lu Q, Feketeova E, Xu DZ. PMID: 18180696.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    53. Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway. Ann Surg. 2007 Nov; 246(5):822-30. Senthil M, Watkins A, Barlos D, Xu DZ, Lu Q, Abungu B, Caputo F, Feinman R, Deitch EA. PMID: 17968175.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    54. Pancreatic duct ligation abrogates the trauma hemorrhage-induced gut barrier failure and the subsequent production of biologically active intestinal lymph. Shock. 2007 Oct; 28(4):441-6. Caputo FJ, Rupani B, Watkins AC, Barlos D, Vega D, Senthil M, Deitch EA. PMID: 17558354.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    55. Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome: validating studies in a porcine model. J Trauma. 2006 May; 60(5):958-65; discussion 965-7. Senthil M, Brown M, Xu DZ, Lu Q, Feketeova E, Deitch EA. PMID: 16688055.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    56. Albumin peptide: a molecular marker for trauma/hemorrhagic-shock in rat mesenteric lymph. Peptides. 2005 Dec; 26(12):2491-9. Kaiser VL, Sifri ZC, Senthil M, Dikdan GS, Lu Q, Xu DZ, Deitch EA. PMID: 15946770.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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