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Cotman, Carl W

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentNeurology
Address1113 Gillespie Building
Zot 4540
Irvine CA 92697
Phone(949) 824-5847
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    Other Positions
    TitleProfessor


    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic suppression of histone methylation reverses age and AD-related cognitive decline
    NIH/NIA R01AG057558Aug 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognition
    NIH/NIA R01AG051807May 15, 2016 - Jan 31, 2021
    Role: Co-Principal Investigator
    A Novel Approach to Study Synaptic Plasticity in Isolated Synaptosomes using Flow Cytometry
    NIH/NIA R21AG048506Sep 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Gene Expression, Compensation Mechanisms, and Successful Cognitive Aging
    NIH/NIA R01AG034667Aug 15, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Brain Aging &Gene Expression Patterns Using Microarrays
    NIH/NIA R01AG023173Sep 30, 2003 - Jul 31, 2009
    Role: Principal Investigator
    ABeta Immunization in Aging
    NIH/NIA R01AG020242Sep 30, 2001 - Jul 31, 2007
    Role: Principal Investigator
    APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    NIH/NINDS R01NS040953Dec 1, 2000 - Nov 30, 2004
    Role: Principal Investigator
    MECHANISMS OF PATHOLOGICAL NEURITIC &SOMAL DEGENERATION
    NIH/NIA R01AG017765Sep 30, 2000 - Aug 31, 2003
    Role: Principal Investigator
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH/NIA P50AG016573Apr 15, 2000 - Mar 31, 2020
    Role: Co-Principal Investigator
    ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    NIH/NIA R01AG013411Sep 30, 1996 - Mar 31, 2005
    Role: Principal Investigator
    The Canine as an Animal Model of Human Aging
    NIH/NIA R37AG012694Sep 30, 1995 - Aug 31, 2016
    Role: Principal Investigator
    CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    NIH/NIA R01AG012694Sep 30, 1995 - Aug 31, 2006
    Role: Principal Investigator
    MECHANISMS AND MOLECULAR PROFILES OF DEGENERATION IN AD
    NIH/NIA R01AG013007May 25, 1995 - Apr 30, 2001
    Role: Principal Investigator
    GENETIC AND BIOCHEMICAL EVENTS IN AB-INDUCED APOPTOSIS
    NIH/NIA R01AG012663Jan 15, 1995 - Dec 31, 1997
    Role: Principal Investigator
    PLASTICITY IN THE DEVELOPING LIMBIC SYSTEM
    NIH/NINDS R01NS027320Apr 1, 1989 - Mar 31, 1994
    Role: Principal Investigator
    NEURONAL PLASTICITY/PATHOLOGY IN ALZHEIMERS DISEASE
    NIH/NIA R35AG007918Jan 1, 1989 - Dec 31, 1995
    Role: Principal Investigator
    Training in the Neurobiology of Aging
    NIH/NIA T32AG000096Sep 29, 1982 - Apr 30, 2019
    Role: Principal Investigator
    Behavioral and Neural Plasticity in the Aged
    NIH/NIA P01AG000538Jan 1, 1977 - Mar 31, 2019
    Role: Principal Investigator
    INTERRELATIONS BETWEEN CHEMICAL &BEHAVIORAL PLASTICITY
    NIH/NIMH R01MH019691Jan 1, 1977 - Dec 31, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 Jun 06; e12791. PMID: 29877034.
      View in: PubMed
    2. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Deposition of phosphorylated amyloid-ß in brains of aged nonhuman primates and canines. Brain Pathol. 2018 May; 28(3):427-430. PMID: 29740941.
      View in: PubMed
    3. Tong L, Prieto GA, Cotman CW. IL-1ß suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation. J Neuroinflammation. 2018 Apr 30; 15(1):127. PMID: 29712570.
      View in: PubMed
    4. Prieto GA, Tong L, Smith ED, Cotman CW. TNFa and IL-1ß but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse. Neurochem Res. 2018 Apr 04. PMID: 29619614.
      View in: PubMed
    5. Prieto GA, Cotman CW. On the road towards the global analysis of human synapses. Neural Regen Res. 2017 Oct; 12(10):1586-1589. PMID: 29171413.
      View in: PubMed
    6. Prieto GA, Cotman CW. Cytokines and cytokine networks target neurons to modulate long-term potentiation. Cytokine Growth Factor Rev. 2017 Apr; 34:27-33. PMID: 28377062.
      View in: PubMed
    7. Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW. Pattern separation and goal-directed behavior in the aged canine. Learn Mem. 2017 03; 24(3):123-131. PMID: 28202716.
      View in: PubMed
    8. Carlos AJ, Tong L, Prieto GA, Cotman CW. IL-1ß impairs retrograde flow of BDNF signaling by attenuating endosome trafficking. J Neuroinflammation. 2017 Feb 02; 14(1):29. PMID: 28153028.
      View in: PubMed
    9. Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. J Neurosci. 2017 Feb 01; 37(5):1197-1212. PMID: 27986924.
      View in: PubMed
    10. Abbasi A, de Paula Vieira R, Bischof F, Walter M, Movassaghi M, Berchtold NC, Niess AM, Cotman CW, Northoff H. Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise. J Neuroinflammation. 2016 11 10; 13(1):289. PMID: 27832807.
      View in: PubMed
    11. Snigdha S, Prieto GA, Petrosyan A, Loertscher BM, Dieskau AP, Overman LE, Cotman CW. H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. J Neurosci. 2016 Mar 23; 36(12):3611-22. PMID: 27013689; PMCID: PMC4804016.
      View in: PubMed, PubMed Central
    12. Hoffmann K, Sobol NA, Frederiksen KS, Beyer N, Vogel A, Vestergaard K, Brændgaard H, Gottrup H, Lolk A, Wermuth L, Jacobsen S, Laugesen LP, Gergelyffy RG, Høgh P, Bjerregaard E, Andersen BB, Siersma V, Johannsen P, Cotman CW, Waldemar G, Hasselbalch SG. Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial. J Alzheimers Dis. 2016; 50(2):443-53. PMID: 26682695.
      View in: PubMed
    13. Snigdha S, de Rivera C, Milgram NW, Cotman CW. Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiol Aging. 2016 Jan; 37:171-178. PMID: 26481404.
      View in: PubMed
    14. Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J, Cotman CW. Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1ß in the aged hippocampus. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5078-87. PMID: 26305968; PMCID: PMC4568670.
      View in: PubMed, PubMed Central
    15. Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW. Rapamycin and interleukin-1ß impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem. 2014 Jul 25; 289(30):20615-29. PMID: 24917666; PMCID: PMC4110274.
      View in: PubMed, PubMed Central
    16. Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW. Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease. Neurobiol Aging. 2014 Sep; 35(9):1961-72. PMID: 24786631; PMCID: PMC4067010.
      View in: PubMed, PubMed Central
    17. Snigdha S, de Rivera C, Milgram NW, Cotman CW. Exercise enhances memory consolidation in the aging brain. Front Aging Neurosci. 2014; 6:3. PMID: 24550824; PMCID: PMC3910002.
      View in: PubMed, PubMed Central
    18. Rice RA, Berchtold NC, Cotman CW, Green KN. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014 May; 35(5):1002-11. PMID: 24268883; PMCID: PMC3939046.
      View in: PubMed, PubMed Central
    19. Hoffmann K, Frederiksen KS, Sobol NA, Beyer N, Vogel A, Simonsen AH, Johannsen P, Lolk A, Terkelsen O, Cotman CW, Hasselbalch SG, Waldemar G. Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design. Neuroepidemiology. 2013; 41(3-4):198-207. PMID: 24135720.
      View in: PubMed
    20. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948.
      View in: PubMed
    21. Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ, Wood MA, Cotman CW. Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology. 2013 Sep; 38(10):2027-34. PMID: 23615664; PMCID: PMC3746687.
      View in: PubMed, PubMed Central
    22. Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW. ß-Amyloid (Aß) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem. 2013 Jun 07; 288(23):16937-48. PMID: 23599427; PMCID: PMC3675626.
      View in: PubMed, PubMed Central
    23. Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW. A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiol Aging. 2013 Jul; 34(7):1891-901. PMID: 23434040; PMCID: PMC3650917.
      View in: PubMed, PubMed Central
    24. Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW. Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging. 2013 Jun; 34(6):1653-61. PMID: 23273601; PMCID: PMC4022280.
      View in: PubMed, PubMed Central
    25. Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW. Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1ß via p38 mitogen-activated protein kinase. J Neurosci. 2012 Dec 05; 32(49):17714-24. PMID: 23223292; PMCID: PMC3687587.
      View in: PubMed, PubMed Central
    26. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012 Jul 23; 9:179. PMID: 22824372; PMCID: PMC3419089.
      View in: PubMed, PubMed Central
    27. Intlekofer KA, Cotman CW. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis. 2013 Sep; 57:47-55. PMID: 22750524.
      View in: PubMed
    28. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. PMID: 22722634.
      View in: PubMed
    29. Kim HJ, Park JW, Byun JH, Poon WW, Cotman CW, Fowlkes CC, Jeon NL. Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. ACS Chem Neurosci. 2012 Jun 20; 3(6):433-8. PMID: 24358503; PMCID: PMC3643179.
      View in: PubMed, PubMed Central
    30. Chapman SB, Cotman CW, Fillit HM, Gallagher M, van Dyck CH. Clinical trials: new opportunities. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):773-80. PMID: 22570132; PMCID: PMC3708514.
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    31. Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. PMID: 22556362.
      View in: PubMed
    32. Snigdha S, Smith ED, Prieto GA, Cotman CW. Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull. 2012 Feb; 28(1):14-24. PMID: 22233886; PMCID: PMC3838299.
      View in: PubMed, PubMed Central
    33. Deeny SP, Winchester J, Nichol K, Roth SM, Wu JC, Dick M, Cotman CW. Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ?4 carriers. Alzheimers Dement. 2012 Jul; 8(4):352-6. PMID: 22226798; PMCID: PMC3360109.
      View in: PubMed, PubMed Central
    34. Segal SK, Cotman CW, Cahill LF. Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. J Alzheimers Dis. 2012; 32(4):1011-8. PMID: 22914593; PMCID: PMC3951984.
      View in: PubMed, PubMed Central
    35. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. PMID: 22046234; PMCID: PMC3202527.
      View in: PubMed, PubMed Central
    36. Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW. Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One. 2011; 6(9):e24652. PMID: 21931796; PMCID: PMC3172245.
      View in: PubMed, PubMed Central
    37. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid ß42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. PMID: 21546126.
      View in: PubMed
    38. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841.
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    39. Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW. Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordr). 2012 Feb; 34(1):67-73. PMID: 21336566; PMCID: PMC3260365.
      View in: PubMed, PubMed Central
    40. Adlard PA, Engesser-Cesar C, Cotman CW. Mild stress facilitates learning and exercise improves retention in aged mice. Exp Gerontol. 2011 Jan; 46(1):53-9. PMID: 20951791.
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    41. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. PMID: 20838618; PMCID: PMC2935886.
      View in: PubMed, PubMed Central
    42. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci. 2010 Jul 21; 30(29):9831-9. PMID: 20660265; PMCID: PMC3769160.
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    43. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis. 2010 Sep; 39(3):301-10. PMID: 20451612; PMCID: PMC2910127.
      View in: PubMed, PubMed Central
    44. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012 Mar; 33(3):546-54. PMID: 20447733; PMCID: PMC2935515.
      View in: PubMed, PubMed Central
    45. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aß aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. PMID: 20434811; PMCID: PMC2932860.
      View in: PubMed, PubMed Central
    46. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673.
      View in: PubMed
    47. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. PMID: 20463402; PMCID: PMC4175722.
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    48. Acharya MM, Christie LA, Lan ML, Donovan PJ, Cotman CW, Fike JR, Limoli CL. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19150-5. PMID: 19901336; PMCID: PMC2776427.
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    49. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec; 44(12):752-9. PMID: 19735717; PMCID: PMC2787885.
      View in: PubMed, PubMed Central
    50. Nichol K, Deeny SP, Seif J, Camaclang K, Cotman CW. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement. 2009 Jul; 5(4):287-94. PMID: 19560099; PMCID: PMC4105011.
      View in: PubMed, PubMed Central
    51. Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. ß-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging. 2011 May; 32(5):821-33. PMID: 19540623; PMCID: PMC3038182.
      View in: PubMed, PubMed Central
    52. Taylor AM, Berchtold NC, Perreau VM, Tu CH, Li Jeon N, Cotman CW. Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci. 2009 Apr 15; 29(15):4697-707. PMID: 19369540; PMCID: PMC3632375.
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    53. Cotman CW, Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec; 15(4):685-707. PMID: 19096165.
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    54. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol. 2008 Nov 10; 511(2):257-70. PMID: 18792072; PMCID: PMC4105010.
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    55. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009 Apr; 34(4):755-63. PMID: 18846423; PMCID: PMC2790461.
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    56. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15605-10. PMID: 18832152; PMCID: PMC2563070.
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    57. Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation. 2008 Apr 09; 5:13. PMID: 18400101; PMCID: PMC2329612.
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    58. Li X, Liu Z, Luo C, Jia H, Sun L, Hou B, Shen W, Packer L, Cotman CW, Liu J. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2008 Apr 01; 44(7):1465-74. PMID: 18258206; PMCID: PMC2597696.
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    59. Siegenthaler MM, Berchtold NC, Cotman CW, Keirstead HS. Voluntary running attenuates age-related deficits following SCI. Exp Neurol. 2008 Mar; 210(1):207-16. PMID: 18164294; PMCID: PMC2387276.
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    60. Harris J, Lee H, Vahidi B, Tu C, Cribbs D, Cotman C, Jeon NL. Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices. J Vis Exp. 2007; (9):410. PMID: 18989450; PMCID: PMC2566327.
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    61. Soiampornkul R, Tong L, Thangnipon W, Balazs R, Cotman CW. Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain Res. 2008 Jan 10; 1188:189-97. PMID: 18036576; PMCID: PMC2409119.
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    62. Harris J, Lee H, Tu CT, Cribbs D, Cotman C, Jeon NL. Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device. J Vis Exp. 2007; (8):305. PMID: 18989412; PMCID: PMC2562488.
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    63. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. PMID: 17897471; PMCID: PMC2100048.
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    64. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007 Sep; 30(9):464-72. PMID: 17765329.
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    65. Harris J, Lee H, Vahidi B, Tu C, Cribbs D, Jeon NL, Cotman C. Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons. J Vis Exp. 2007; (7):261. PMID: 18989432; PMCID: PMC2565860.
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    66. Nichol KE, Parachikova AI, Cotman CW. Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res. 2007 Dec 03; 184(2):124-32. PMID: 17698211; PMCID: PMC2215770.
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    67. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem. 2007 Sep; 88(2):249-59. PMID: 17587610; PMCID: PMC2173881.
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    68. Tong L, Balazs R, Soiampornkul R, Thangnipon W, Cotman CW. Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging. 2008 Sep; 29(9):1380-93. PMID: 17467122; PMCID: PMC4052889.
      View in: PubMed, PubMed Central
    69. Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW, Anderson AJ. Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr; 25(7):1931-9. PMID: 17439482.
      View in: PubMed
    70. Cotman CW, Berchtold NC. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement. 2007 Apr; 3(2 Suppl):S30-7. PMID: 19595972.
      View in: PubMed
    71. Rhee SW, Taylor AM, Cribbs DH, Cotman CW, Jeon NL. External force-assisted cell positioning inside microfluidic devices. Biomed Microdevices. 2007 Feb; 9(1):15-23. PMID: 17091393.
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    72. Christie LA, Su JH, Tu CH, Dick MC, Zhou J, Cotman CW. Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol Dis. 2007 Apr; 26(1):165-73. PMID: 17292615; PMCID: PMC2198925.
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    73. Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):339-48. PMID: 17197552; PMCID: PMC2597695.
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    74. Sharman EH, Bondy SC, Sharman KG, Lahiri D, Cotman CW, Perreau VM. Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochem Int. 2007 Jan; 50(2):336-44. PMID: 17118492; PMCID: PMC1868445.
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    75. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan; 29(1):39-50. PMID: 17092609; PMCID: PMC2198929.
      View in: PubMed, PubMed Central
    76. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan; 29(1):51-70. PMID: 17055614; PMCID: PMC2203613.
      View in: PubMed, PubMed Central
    77. Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG. Musashi1 antigen expression in human fetal germinal matrix development. Exp Neurol. 2006 Oct; 201(2):515-8. PMID: 16777095.
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    78. Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem. 2006 Sep; 86(2):197-204. PMID: 16616528.
      View in: PubMed
    79. Dishman RK, Berthoud HR, Booth FW, Cotman CW, Edgerton VR, Fleshner MR, Gandevia SC, Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, Levin BE, Moran TH, Russo-Neustadt AA, Salamone JD, Van Hoomissen JD, Wade CE, York DA, Zigmond MJ. Neurobiology of exercise. Obesity (Silver Spring). 2006 Mar; 14(3):345-56. PMID: 16648603.
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    80. Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 Apr 05; 24(15):2824-34. PMID: 16460841.
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    81. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. PMID: 16271803.
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    82. Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005 Sep 01; 227(5):722-8. PMID: 16178393.
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    83. Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods. 2005 Aug; 2(8):599-605. PMID: 16094385; PMCID: PMC1558906.
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    84. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. PMID: 15986225.
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    85. Cotman CW. The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo. Neurochem Res. 2005 Jun-Jul; 30(6-7):877-81. PMID: 16187222.
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    86. Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordr). 2005 Mar; 27(1):27-37. PMID: 23598601; PMCID: PMC3456092.
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    87. Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 2005 May; 26(5):749-63. PMID: 15708450.
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    88. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Apr 27; 25(17):4217-21. PMID: 15858047.
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    89. Adlard PA, Perreau VM, Cotman CW. The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging. 2005 Apr; 26(4):511-20. PMID: 15653179.
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    90. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):461-9. PMID: 15795055.
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    91. Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):361-9. PMID: 15795044.
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    92. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. PMID: 15751224.
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    93. Engesser-Cesar C, Anderson AJ, Basso DM, Edgerton VR, Cotman CW. Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma. 2005 Jan; 22(1):157-71. PMID: 15665610.
      View in: PubMed
    94. Perreau VM, Adlard PA, Anderson AJ, Cotman CW. Exercise-induced gene expression changes in the rat spinal cord. Gene Expr. 2005; 12(2):107-21. PMID: 15892452.
      View in: PubMed
    95. Anderson AJ, Robert S, Huang W, Young W, Cotman CW. Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma. 2004 Dec; 21(12):1831-46. PMID: 15684772.
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    96. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci. 2004 Nov; 1033:117-31. PMID: 15591009.
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    97. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004 Sep 22; 24(38):8205-13. PMID: 15385603.
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    98. Glaser J, Gonzalez R, Perreau VM, Cotman CW, Keirstead HS. Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury. J Neurosci Res. 2004 Sep 01; 77(5):701-8. PMID: 15352216.
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    99. Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res. 2004 Aug 12; 153(1):199-210. PMID: 15219721.
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    100. Tong L, Balazs R, Thornton PL, Cotman CW. Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci. 2004 Jul 28; 24(30):6799-809. PMID: 15282285.
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    101. Rhee SW, Taylor AM, Tu CH, Cribbs DH, Cotman CW, Jeon NL. Patterned cell culture inside microfluidic devices. Lab Chip. 2005 Jan; 5(1):102-7. PMID: 15616747.
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    102. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. PMID: 15232619; PMCID: PMC437967.
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    103. Adlard PA, Perreau VM, Engesser-Cesar C, Cotman CW. The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett. 2004 Jun 03; 363(1):43-8. PMID: 15157993.
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    104. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004 May; 39(5):753-65. PMID: 15130670.
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    105. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord. 2004; 17(4):360-7. PMID: 15178954; PMCID: PMC2637356.
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    106. Zhao M, Su J, Head E, Cotman CW. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. PMID: 14678756.
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    107. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. PMID: 14570555.
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    108. Bi X, Head E, Cotman CW, Lynch G. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. PMID: 12900930.
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    109. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. PMID: 12931965.
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    110. Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 2003 May 09; 971(2):239-44. PMID: 12706240.
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    111. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. PMID: 12702875.
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    112. Su JH, Anderson AJ, Cribbs DH, Tu C, Tong L, Kesslack P, Cotman CW. Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis. 2003 Apr; 12(3):182-93. PMID: 12742739.
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    113. Cribbs DH, Ghochikyan A, Vasilevko V, Tran M, Petrushina I, Sadzikava N, Babikyan D, Kesslak P, Kieber-Emmons T, Cotman CW, Agadjanyan MG. Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol. 2003 Apr; 15(4):505-14. PMID: 12663680; PMCID: PMC1483061.
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    114. Taylor AM, Rhee SW, Tu CH, Cribbs DH, Cotman CW, Jeon NL. Microfluidic Multicompartment Device for Neuroscience Research. Langmuir. 2003 Mar 04; 19(5):1551-1556. PMID: 20725530.
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    115. Zhao M, Cribbs DH, Anderson AJ, Cummings BJ, Su JH, Wasserman AJ, Cotman CW. The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res. 2003 Feb; 28(2):307-18. PMID: 12608703.
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    116. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. PMID: 12551965; PMCID: PMC196651.
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    117. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. PMID: 12505426.
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    118. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. PMID: 12480733.
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    119. Rohn TT, Rissman RA, Head E, Cotman CW. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. PMID: 12677194.
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    120. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. PMID: 12213643.
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    121. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. PMID: 12392784.
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    122. Albert KA, Hemmings HC, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry. 2002 Aug; 59(8):705-12. PMID: 12150646.
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    123. Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul; 77(7):681-96. PMID: 12108606.
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    124. Berchtold NC, Kesslak JP, Cotman CW. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res. 2002 Jun 01; 68(5):511-21. PMID: 12111841.
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    125. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002 Jun; 25(6):295-301. PMID: 12086747.
      View in: PubMed
    126. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. PMID: 12049325.
      View in: PubMed
    127. Su JH, Kesslak JP, Head E, Cotman CW. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. PMID: 12070657.
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    128. Cotman CW, Engesser-Cesar C. Exercise enhances and protects brain function. Exerc Sport Sci Rev. 2002 Apr; 30(2):75-9. PMID: 11991541.
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    129. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. PMID: 11854529; PMCID: PMC122369.
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    130. Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94. PMID: 12025818.
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    131. Cotman CW, Anderson AJ. The brain's microenvironment, early functional loss, and the conversion to Alzheimer's disease. Ann N Y Acad Sci. 2000; 924:112-6. PMID: 11193787.
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