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Carl W. Cotman

Title(s)Professor, Neurology
Phone(949) 824-5847
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    Other Positions
    Title(s)Professor, Neurobiology & Behavior


    Collapse Research 
    Collapse Research Activities and Funding
    Epigenetic suppression of histone methylation reverses age and AD-related cognitive decline
    NIH/NIA R01AG057558Aug 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognition
    NIH/NIA R01AG051807May 15, 2016 - Jan 31, 2021
    Role: Co-Principal Investigator
    A Novel Approach to Study Synaptic Plasticity in Isolated Synaptosomes using Flow Cytometry
    NIH/NIA R21AG048506Sep 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Gene Expression, Compensation Mechanisms, and Successful Cognitive Aging
    NIH/NIA R01AG034667Aug 15, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Brain Aging &Gene Expression Patterns Using Microarrays
    NIH/NIA R01AG023173Sep 30, 2003 - Jul 31, 2009
    Role: Principal Investigator
    ABeta Immunization in Aging
    NIH/NIA R01AG020242Sep 30, 2001 - Jul 31, 2007
    Role: Principal Investigator
    APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    NIH/NINDS R01NS040953Dec 1, 2000 - Nov 30, 2004
    Role: Principal Investigator
    MECHANISMS OF PATHOLOGICAL NEURITIC &SOMAL DEGENERATION
    NIH/NIA R01AG017765Sep 30, 2000 - Aug 31, 2003
    Role: Principal Investigator
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH/NIA P50AG016573Apr 15, 2000 - Mar 31, 2020
    Role: Co-Principal Investigator
    ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    NIH/NIA R01AG013411Sep 30, 1996 - Mar 31, 2005
    Role: Principal Investigator
    The Canine as an Animal Model of Human Aging
    NIH/NIA R37AG012694Sep 30, 1995 - Aug 31, 2016
    Role: Principal Investigator
    CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    NIH/NIA R01AG012694Sep 30, 1995 - Aug 31, 2006
    Role: Principal Investigator
    MECHANISMS AND MOLECULAR PROFILES OF DEGENERATION IN AD
    NIH/NIA R01AG013007May 25, 1995 - Apr 30, 2001
    Role: Principal Investigator
    GENETIC AND BIOCHEMICAL EVENTS IN AB-INDUCED APOPTOSIS
    NIH/NIA R01AG012663Jan 15, 1995 - Dec 31, 1997
    Role: Principal Investigator
    PLASTICITY IN THE DEVELOPING LIMBIC SYSTEM
    NIH/NINDS R01NS027320Apr 1, 1989 - Mar 31, 1994
    Role: Principal Investigator
    NEURONAL PLASTICITY/PATHOLOGY IN ALZHEIMERS DISEASE
    NIH/NIA R35AG007918Jan 1, 1989 - Dec 31, 1995
    Role: Principal Investigator
    Training in the Neurobiology of Aging and Alzheimer's Disease
    NIH/NIA T32AG000096Sep 29, 1982 - Apr 30, 2024
    Role: Principal Investigator
    Behavioral and Neural Plasticity in the Aged
    NIH/NIA P01AG000538Jan 1, 1977 - Mar 31, 2019
    Role: Principal Investigator
    INTERRELATIONS BETWEEN CHEMICAL &BEHAVIORAL PLASTICITY
    NIH/NIMH R01MH019691Jan 1, 1977 - Dec 31, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Butler CW, Keiser AA, Kwapis JL, Berchtold NC, Wall VL, Wood MA, Cotman CW. Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity. Learn Mem. 2019 Dec; 26(12):485-492. PMID: 31732709.
      View in: PubMed
    2. Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. Intra- and extracellular ß-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 Nov 04; 9(1):15936. PMID: 31685865.
      View in: PubMed
    3. Ayer AH, Wojta K, Ramos EM, Dokuru D, Chen JA, Karydas AM, Papatriantafyllou JD, Agiomyrgiannakis D, Kamtsadeli V, Tsinia N, Sali D, Gylys KH, Agosta F, Filippi M, Small GW, Bennett DA, Gearing M, Juncos JL, Kramer J, Lee SE, Yokoyama JS, Mendez MF, Chui H, Zarow C, Ringman JM, Kilic U, Babacan-Yildiz G, Levey A, DeCarli CS, Cotman CW, Boxer AL, Miller BL, Coppola G. Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. Alzheimer Dis Assoc Disord. 2019 Sep 10. PMID: 31513029.
      View in: PubMed
    4. Walhovd KB, Howell GR, Ritchie SJ, Staff RT, Cotman CW. What are the earlier life contributions to reserve and resilience? Neurobiol Aging. 2019 Nov; 83:135-139. PMID: 31307838.
      View in: PubMed
    5. Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM. Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. Aging Cell. 2019 Jun; 18(3):e12919. PMID: 30809950.
      View in: PubMed
    6. Berchtold NC, Prieto GA, Phelan M, Gillen DL, Baldi P, Bennett DA, Buchman AS, Cotman CW. Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline. Neurobiol Aging. 2019 06; 78:142-154. PMID: 30927700.
      View in: PubMed
    7. Prieto GA, Smith ED, Tong L, Nguyen M, Cotman CW. Inhibition of LTP-Induced Translation by IL-1ß Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites. ACS Chem Neurosci. 2019 03 20; 10(3):1197-1203. PMID: 30695637.
      View in: PubMed
    8. Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 08; 17(4):e12791. PMID: 29877034.
      View in: PubMed
    9. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Deposition of phosphorylated amyloid-ß in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. PMID: 29740941.
      View in: PubMed
    10. Tong L, Prieto GA, Cotman CW. IL-1ß suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation. J Neuroinflammation. 2018 Apr 30; 15(1):127. PMID: 29712570.
      View in: PubMed
    11. Prieto GA, Tong L, Smith ED, Cotman CW. TNFa and IL-1ß but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse. Neurochem Res. 2019 Jan; 44(1):49-60. PMID: 29619614.
      View in: PubMed
    12. Prieto GA, Cotman CW. On the road towards the global analysis of human synapses. Neural Regen Res. 2017 Oct; 12(10):1586-1589. PMID: 29171413.
      View in: PubMed
    13. Prieto GA, Cotman CW. Cytokines and cytokine networks target neurons to modulate long-term potentiation. Cytokine Growth Factor Rev. 2017 Apr; 34:27-33. PMID: 28377062.
      View in: PubMed
    14. Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW. Pattern separation and goal-directed behavior in the aged canine. Learn Mem. 2017 03; 24(3):123-131. PMID: 28202716.
      View in: PubMed
    15. Carlos AJ, Tong L, Prieto GA, Cotman CW. IL-1ß impairs retrograde flow of BDNF signaling by attenuating endosome trafficking. J Neuroinflammation. 2017 02 02; 14(1):29. PMID: 28153028.
      View in: PubMed
    16. Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. J Neurosci. 2017 02 01; 37(5):1197-1212. PMID: 27986924.
      View in: PubMed
    17. Abbasi A, de Paula Vieira R, Bischof F, Walter M, Movassaghi M, Berchtold NC, Niess AM, Cotman CW, Northoff H. Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise. J Neuroinflammation. 2016 11 10; 13(1):289. PMID: 27832807.
      View in: PubMed
    18. Snigdha S, Prieto GA, Petrosyan A, Loertscher BM, Dieskau AP, Overman LE, Cotman CW. H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. J Neurosci. 2016 Mar 23; 36(12):3611-22. PMID: 27013689.
      View in: PubMed
    19. Hoffmann K, Sobol NA, Frederiksen KS, Beyer N, Vogel A, Vestergaard K, Brændgaard H, Gottrup H, Lolk A, Wermuth L, Jacobsen S, Laugesen LP, Gergelyffy RG, Høgh P, Bjerregaard E, Andersen BB, Siersma V, Johannsen P, Cotman CW, Waldemar G, Hasselbalch SG. Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial. J Alzheimers Dis. 2016; 50(2):443-53. PMID: 26682695.
      View in: PubMed
    20. Snigdha S, de Rivera C, Milgram NW, Cotman CW. Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiol Aging. 2016 Jan; 37:171-178. PMID: 26481404.
      View in: PubMed
    21. Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J, Cotman CW. Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1ß in the aged hippocampus. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5078-87. PMID: 26305968.
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    22. Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW. Rapamycin and interleukin-1ß impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem. 2014 Jul 25; 289(30):20615-29. PMID: 24917666.
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    23. Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW. Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease. Neurobiol Aging. 2014 Sep; 35(9):1961-72. PMID: 24786631.
      View in: PubMed
    24. Snigdha S, de Rivera C, Milgram NW, Cotman CW. Exercise enhances memory consolidation in the aging brain. Front Aging Neurosci. 2014; 6:3. PMID: 24550824.
      View in: PubMed
    25. Rice RA, Berchtold NC, Cotman CW, Green KN. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014 May; 35(5):1002-11. PMID: 24268883.
      View in: PubMed
    26. Hoffmann K, Frederiksen KS, Sobol NA, Beyer N, Vogel A, Simonsen AH, Johannsen P, Lolk A, Terkelsen O, Cotman CW, Hasselbalch SG, Waldemar G. Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design. Neuroepidemiology. 2013; 41(3-4):198-207. PMID: 24135720.
      View in: PubMed
    27. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. PMID: 23747948.
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    28. Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ, Wood MA, Cotman CW. Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology. 2013 Sep; 38(10):2027-34. PMID: 23615664.
      View in: PubMed
    29. Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW. ß-Amyloid (Aß) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem. 2013 Jun 07; 288(23):16937-48. PMID: 23599427.
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    30. Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW. A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiol Aging. 2013 Jul; 34(7):1891-901. PMID: 23434040.
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    31. Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW. Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging. 2013 Jun; 34(6):1653-61. PMID: 23273601.
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    32. Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW. Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1ß via p38 mitogen-activated protein kinase. J Neurosci. 2012 Dec 05; 32(49):17714-24. PMID: 23223292.
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    33. Winchester J, Dick MB, Gillen D, Reed B, Miller B, Tinklenberg J, Mungas D, Chui H, Galasko D, Hewett L, Cotman CW. Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year. Arch Gerontol Geriatr. 2013 Jan-Feb; 56(1):96-103. PMID: 22959822.
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    34. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012 Jul 23; 9:179. PMID: 22824372.
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    35. Intlekofer KA, Cotman CW. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis. 2013 Sep; 57:47-55. PMID: 22750524.
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    36. Kim HJ, Park JW, Byun JH, Poon WW, Cotman CW, Fowlkes CC, Jeon NL. Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. ACS Chem Neurosci. 2012 Jun 20; 3(6):433-8. PMID: 24358503.
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    37. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. PMID: 22722634.
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    38. Chapman SB, Cotman CW, Fillit HM, Gallagher M, van Dyck CH. Clinical trials: new opportunities. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):773-80. PMID: 22570132.
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    39. Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E, Geschwind DH. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. PMID: 22556362.
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    40. Snigdha S, Smith ED, Prieto GA, Cotman CW. Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull. 2012 Feb; 28(1):14-24. PMID: 22233886.
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    41. Deeny SP, Winchester J, Nichol K, Roth SM, Wu JC, Dick M, Cotman CW. Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ?4 carriers. Alzheimers Dement. 2012 Jul; 8(4):352-6. PMID: 22226798.
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    42. Segal SK, Cotman CW, Cahill LF. Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. J Alzheimers Dis. 2012; 32(4):1011-8. PMID: 22914593.
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    43. Snigdha S, Astarita G, Piomelli D, Cotman CW. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012 Jan 27; 202:326-33. PMID: 22183056.
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    44. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. PMID: 22046234.
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    45. Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW. Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One. 2011; 6(9):e24652. PMID: 21931796.
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    46. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid ß42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. PMID: 21546126.
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    47. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841.
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    48. Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW. Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordr). 2012 Feb; 34(1):67-73. PMID: 21336566.
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    49. Adlard PA, Engesser-Cesar C, Cotman CW. Mild stress facilitates learning and exercise improves retention in aged mice. Exp Gerontol. 2011 Jan; 46(1):53-9. PMID: 20951791.
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    50. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. PMID: 20838618.
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    51. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci. 2010 Jul 21; 30(29):9831-9. PMID: 20660265.
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    52. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis. 2010 Sep; 39(3):301-10. PMID: 20451612.
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    53. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012 Mar; 33(3):546-54. PMID: 20447733.
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    54. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aß aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. PMID: 20434811.
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    55. Berchtold NC, Castello N, Cotman CW. Exercise and time-dependent benefits to learning and memory. Neuroscience. 2010 May 19; 167(3):588-97. PMID: 20219647.
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    56. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. PMID: 20154673.
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    57. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. PMID: 20463402.
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    58. Acharya MM, Christie LA, Lan ML, Donovan PJ, Cotman CW, Fike JR, Limoli CL. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19150-5. PMID: 19901336.
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    59. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec; 44(12):752-9. PMID: 19735717.
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    60. Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol. 2009 Nov; 220(1):171-6. PMID: 19703441.
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    61. Nichol K, Deeny SP, Seif J, Camaclang K, Cotman CW. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement. 2009 Jul; 5(4):287-94. PMID: 19560099.
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    62. Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. ß-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging. 2011 May; 32(5):821-33. PMID: 19540623.
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    63. Taylor AM, Berchtold NC, Perreau VM, Tu CH, Li Jeon N, Cotman CW. Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci. 2009 Apr 15; 29(15):4697-707. PMID: 19369540.
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    64. Cotman CW, Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec; 15(4):685-707. PMID: 19096165.
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    65. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol. 2008 Nov 10; 511(2):257-70. PMID: 18792072.
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    66. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009 Apr; 34(4):755-63. PMID: 18846423.
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    67. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15605-10. PMID: 18832152.
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    68. Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation. 2008 Apr 09; 5:13. PMID: 18400101.
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    69. Li X, Liu Z, Luo C, Jia H, Sun L, Hou B, Shen W, Packer L, Cotman CW, Liu J. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2008 Apr 01; 44(7):1465-74. PMID: 18258206.
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    70. Parachikova A, Nichol KE, Cotman CW. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiol Dis. 2008 Apr; 30(1):121-9. PMID: 18258444.
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    71. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, Liu J. R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia. 2008 Jan; 51(1):165-74. PMID: 18026715.
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    72. Siegenthaler MM, Berchtold NC, Cotman CW, Keirstead HS. Voluntary running attenuates age-related deficits following SCI. Exp Neurol. 2008 Mar; 210(1):207-16. PMID: 18164294.
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    73. Harris J, Lee H, Vahidi B, Tu C, Cribbs D, Cotman C, Jeon NL. Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices. J Vis Exp. 2007; (9):410. PMID: 18989450.
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    74. Soiampornkul R, Tong L, Thangnipon W, Balazs R, Cotman CW. Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain Res. 2008 Jan 10; 1188:189-97. PMID: 18036576.
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    75. Harris J, Lee H, Tu CT, Cribbs D, Cotman C, Jeon NL. Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device. J Vis Exp. 2007; (8):305. PMID: 18989412.
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    76. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. PMID: 17897471.
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    77. Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007 Sep; 30(9):464-72. PMID: 17765329.
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    78. Harris J, Lee H, Vahidi B, Tu C, Cribbs D, Jeon NL, Cotman C. Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons. J Vis Exp. 2007; (7):261. PMID: 18989432.
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    79. Nichol KE, Parachikova AI, Cotman CW. Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res. 2007 Dec 03; 184(2):124-32. PMID: 17698211.
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    80. Parachikova A, Cotman CW. Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease. Neurobiol Dis. 2007 Nov; 28(2):143-53. PMID: 17764962.
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    81. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem. 2007 Sep; 88(2):249-59. PMID: 17587610.
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    82. Tong L, Balazs R, Soiampornkul R, Thangnipon W, Cotman CW. Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging. 2008 Sep; 29(9):1380-93. PMID: 17467122.
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    83. Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW, Anderson AJ. Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr; 25(7):1931-9. PMID: 17439482.
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    84. Cotman CW, Berchtold NC. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement. 2007 Apr; 3(2 Suppl):S30-7. PMID: 19595972.
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    85. Rhee SW, Taylor AM, Cribbs DH, Cotman CW, Jeon NL. External force-assisted cell positioning inside microfluidic devices. Biomed Microdevices. 2007 Feb; 9(1):15-23. PMID: 17091393.
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    86. Celsi F, Svedberg M, Unger C, Cotman CW, Carrì MT, Ottersen OP, Nordberg A, Torp R. Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress. Neurobiol Dis. 2007 May; 26(2):342-52. PMID: 17344052.
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    87. Christie LA, Su JH, Tu CH, Dick MC, Zhou J, Cotman CW. Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol Dis. 2007 Apr; 26(1):165-73. PMID: 17292615.
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    88. Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):339-48. PMID: 17197552.
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    89. Engesser-Cesar C, Anderson AJ, Cotman CW. Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord. Neuroscience. 2007 Feb 09; 144(3):1033-44. PMID: 17137724.
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    90. Sharman EH, Bondy SC, Sharman KG, Lahiri D, Cotman CW, Perreau VM. Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochem Int. 2007 Jan; 50(2):336-44. PMID: 17118492.
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    91. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan; 29(1):39-50. PMID: 17092609.
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    92. Perreau VM, Bondy SC, Cotman CW, Sharman KG, Sharman EH. Melatonin treatment in old mice enables a more youthful response to LPS in the brain. J Neuroimmunol. 2007 Jan; 182(1-2):22-31. PMID: 17070935.
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    93. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan; 29(1):51-70. PMID: 17055614.
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    94. Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007 Dec; 28(12):1821-33. PMID: 17052803.
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    95. Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG. Musashi1 antigen expression in human fetal germinal matrix development. Exp Neurol. 2006 Oct; 201(2):515-8. PMID: 16777095.
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    96. Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem. 2006 Sep; 86(2):197-204. PMID: 16616528.
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    97. Dishman RK, Berthoud HR, Booth FW, Cotman CW, Edgerton VR, Fleshner MR, Gandevia SC, Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, Levin BE, Moran TH, Russo-Neustadt AA, Salamone JD, Van Hoomissen JD, Wade CE, York DA, Zigmond MJ. Neurobiology of exercise. Obesity (Silver Spring). 2006 Mar; 14(3):345-56. PMID: 16648603.
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    98. Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 Apr 05; 24(15):2824-34. PMID: 16460841.
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    99. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. PMID: 16271803.
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    100. Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005 Sep 01; 227(5):722-8. PMID: 16178393.
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    101. Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods. 2005 Aug; 2(8):599-605. PMID: 16094385.
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    102. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. PMID: 15986225.
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    103. Cotman CW. The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo. Neurochem Res. 2005 Jun-Jul; 30(6-7):877-81. PMID: 16187222.
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    104. Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordr). 2005 Mar; 27(1):27-37. PMID: 23598601.
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    105. Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 2005 May; 26(5):749-63. PMID: 15708450.
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    106. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Apr 27; 25(17):4217-21. PMID: 15858047.
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    107. Adlard PA, Perreau VM, Cotman CW. The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging. 2005 Apr; 26(4):511-20. PMID: 15653179.
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    108. Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):361-9. PMID: 15795044.
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    109. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):461-9. PMID: 15795055.
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    110. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. PMID: 15751224.
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    111. Engesser-Cesar C, Anderson AJ, Basso DM, Edgerton VR, Cotman CW. Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma. 2005 Jan; 22(1):157-71. PMID: 15665610.
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    112. Perreau VM, Adlard PA, Anderson AJ, Cotman CW. Exercise-induced gene expression changes in the rat spinal cord. Gene Expr. 2005; 12(2):107-21. PMID: 15892452.
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    113. Berchtold NC, Chinn G, Chou M, Kesslak JP, Cotman CW. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience. 2005; 133(3):853-61. PMID: 15896913.
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    114. Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging. 2005 Jan; 26(1):77-90. PMID: 15585348.
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    115. Anderson AJ, Robert S, Huang W, Young W, Cotman CW. Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma. 2004 Dec; 21(12):1831-46. PMID: 15684772.
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    116. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci. 2004 Nov; 1033:117-31. PMID: 15591009.
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    117. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004 Sep 22; 24(38):8205-13. PMID: 15385603.
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    118. Glaser J, Gonzalez R, Perreau VM, Cotman CW, Keirstead HS. Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury. J Neurosci Res. 2004 Sep 01; 77(5):701-8. PMID: 15352216.
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    119. Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res. 2004 Aug 12; 153(1):199-210. PMID: 15219721.
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    120. Tong L, Balazs R, Thornton PL, Cotman CW. Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci. 2004 Jul 28; 24(30):6799-809. PMID: 15282285.
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    121. Rhee SW, Taylor AM, Tu CH, Cribbs DH, Cotman CW, Jeon NL. Patterned cell culture inside microfluidic devices. Lab Chip. 2005 Jan; 5(1):102-7. PMID: 15616747.
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    122. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. PMID: 15232619.
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    123. Adlard PA, Perreau VM, Engesser-Cesar C, Cotman CW. The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett. 2004 Jun 03; 363(1):43-8. PMID: 15157993.
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    124. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004 May; 39(5):753-65. PMID: 15130670.
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    125. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord. 2004; 17(4):360-7. PMID: 15178954.
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    126. Adlard PA, Cotman CW. Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression. Neuroscience. 2004; 124(4):985-92. PMID: 15026138.
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    127. Whitman GT, Cotman CW. Oligodendrocyte degeneration in AD. Neurobiol Aging. 2004 Jan; 25(1):33-6. PMID: 14675727.
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    128. Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology. 2003 Dec 23; 61(12):1673-9. PMID: 14694028.
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    129. Zhao M, Su J, Head E, Cotman CW. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. PMID: 14678756.
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    130. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. PMID: 14570555.
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    131. Bi X, Head E, Cotman CW, Lynch G. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. PMID: 12900930.
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    132. Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. J Neuropathol Exp Neurol. 2003 Sep; 62(9):917-26. PMID: 14533781.
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    133. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. PMID: 12931965.
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    134. Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 2003 May 09; 971(2):239-44. PMID: 12706240.
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    135. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. PMID: 12702875.
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    136. Su JH, Anderson AJ, Cribbs DH, Tu C, Tong L, Kesslack P, Cotman CW. Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis. 2003 Apr; 12(3):182-93. PMID: 12742739.
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    137. Cribbs DH, Ghochikyan A, Vasilevko V, Tran M, Petrushina I, Sadzikava N, Babikyan D, Kesslak P, Kieber-Emmons T, Cotman CW, Agadjanyan MG. Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol. 2003 Apr; 15(4):505-14. PMID: 12663680.
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    138. Taylor AM, Rhee SW, Tu CH, Cribbs DH, Cotman CW, Jeon NL. Microfluidic Multicompartment Device for Neuroscience Research. Langmuir. 2003 Mar 04; 19(5):1551-1556. PMID: 20725530.
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    139. Zhao M, Cribbs DH, Anderson AJ, Cummings BJ, Su JH, Wasserman AJ, Cotman CW. The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res. 2003 Feb; 28(2):307-18. PMID: 12608703.
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    140. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. PMID: 12551965.
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    141. Torp R, Ottersen OP, Cotman CW, Head E. Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. Neuroscience. 2003; 120(2):291-300. PMID: 12890502.
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    142. Garcia C, Chen MJ, Garza AA, Cotman CW, Russo-Neustadt A. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. 2003; 119(3):721-32. PMID: 12809693.
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    143. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. PMID: 12480733.
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    144. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. PMID: 12505426.
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    145. Rohn TT, Rissman RA, Head E, Cotman CW. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. PMID: 12677194.
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    146. Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada J, Ikeda-Douglas CJ, Zicker SC, Cotman CW. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci Biobehav Rev. 2002 Oct; 26(6):679-95. PMID: 12479842.
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    147. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. PMID: 12213643.
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    148. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. PMID: 12392784.
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    149. Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging. 2002 Sep-Oct; 23(5):737-45. PMID: 12392778.
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    150. Albert KA, Hemmings HC, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry. 2002 Aug; 59(8):705-12. PMID: 12150646.
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    151. Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul; 77(7):681-96. PMID: 12108606.
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    152. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002 Jul; 82(2):375-81. PMID: 12124438.
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    153. Berchtold NC, Kesslak JP, Cotman CW. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res. 2002 Jun 01; 68(5):511-21. PMID: 12111841.
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    154. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002 Jun; 25(6):295-301. PMID: 12086747.
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    155. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. PMID: 12049325.
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    156. Su JH, Kesslak JP, Head E, Cotman CW. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. PMID: 12070657.
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    157. Cotman CW, Engesser-Cesar C. Exercise enhances and protects brain function. Exerc Sport Sci Rev. 2002 Apr; 30(2):75-9. PMID: 11991541.
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    158. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. PMID: 11854529.
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    159. SantaCruz KS, Tasaki CS, Kim RC, Cotman CW. Brainstem and cortical Lewy bodies in patients presenting clinically with Alzheimer's disease. J Alzheimers Dis. 2002 Feb; 4(1):11-7. PMID: 12214014.
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    160. Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94. PMID: 12025818.
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    161. Berchtold NC, Kesslak JP, Pike CJ, Adlard PA, Cotman CW. Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus. Eur J Neurosci. 2001 Dec; 14(12):1992-2002. PMID: 11860494.
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    162. Tong L, Shen H, Perreau VM, Balazs R, Cotman CW. Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis. 2001 Dec; 8(6):1046-56. PMID: 11741400.
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    163. Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH. Activation of caspase-8 in the Alzheimer's disease brain. Neurobiol Dis. 2001 Dec; 8(6):1006-16. PMID: 11741396.
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    164. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct; 8(5):792-806. PMID: 11592849.
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    165. Stoltzner SE, Berchtold NC, Cotman CW, Pike CJ. Estrogen regulates bcl-x expression in rat hippocampus. Neuroreport. 2001 Sep 17; 12(13):2797-800. PMID: 11588579.
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    166. Nichol KE, Kim R, Cotman CW. Bcl-2 family protein behavior in frontotemporal dementia implies vascular involvement. Neurology. 2001 Jun; 56(11 Suppl 4):S35-40. PMID: 11402149.
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    167. Su JH, Zhao M, Anderson AJ, Srinivasan A, Cotman CW. Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res. 2001 Apr 20; 898(2):350-7. PMID: 11306022.
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    168. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001 Apr; 8(2):252-65. PMID: 11300721.
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    169. Rohn TT, Wong SM, Cotman CW, Cribbs DH. 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. Neuroreport. 2001 Mar 26; 12(4):839-43. PMID: 11277593.
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    170. Martin JA, Craft DK, Su JH, Kim RC, Cotman CW. Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusion. Neurobiol Aging. 2001 Mar-Apr; 22(2):195-207. PMID: 11182469.
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    171. Tong L, Thornton PL, Balazs R, Cotman CW. Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. J Biol Chem. 2001 May 18; 276(20):17301-6. PMID: 11278679.
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    172. Shen H, Tong L, Balazs R, Cotman CW. Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus. Neuroscience. 2001; 107(2):219-29. PMID: 11731096.
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    173. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol. 2001 Jan; 158(1):189-98. PMID: 11141492.
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    174. Dick MB, Hsieh S, Dick-Muehlke C, Davis DS, Cotman CW. The variability of practice hypothesis in motor learning: does it apply to Alzheimer's disease? Brain Cogn. 2000 Dec; 44(3):470-89. PMID: 11104538.
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    175. Head E, Cotman CW, Milgram NW. Canine cognition, aging and neuropathology. Introduction. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):671-3. PMID: 11191707.
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    176. Callahan H, Ikeda-Douglas C, Head E, Cotman CW, Milgram NW. Development of a protocol for studying object recognition memory in the dog. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):693-707. PMID: 11191709.
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    177. Head E, Thornton PL, Tong L, Cotman CW. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):777-86. PMID: 11191712.
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    178. Torp R, Head E, Cotman CW. Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):801-10. PMID: 11191714.
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    179. Ulas J, Satou T, Ivins KJ, Kesslak JP, Cotman CW, Balázs R. Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures. Glia. 2000 Jun; 30(4):352-61. PMID: 10797615.
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    180. Rohn TT, Ivins KJ, Bahr BA, Cotman CW, Cribbs DH. A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J Neurochem. 2000 Jun; 74(6):2331-42. PMID: 10820193.
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    181. Cribbs DH, Azizeh BY, Cotman CW, LaFerla FM. Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. Biochemistry. 2000 May 23; 39(20):5988-94. PMID: 10821670.
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    182. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Exp Neurol. 2000 May; 163(1):111-22. PMID: 10785449.
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    183. Su JH, Nichol KE, Sitch T, Sheu P, Chubb C, Miller BL, Tomaselli KJ, Kim RC, Cotman CW. DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. Exp Neurol. 2000 May; 163(1):9-19. PMID: 10785439.
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    184. Mulnard RA, Cotman CW, Kawas C, van Dyck CH, Sano M, Doody R, Koss E, Pfeiffer E, Jin S, Gamst A, Grundman M, Thomas R, Thal LJ. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA. 2000 Feb 23; 283(8):1007-15. PMID: 10697060.
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    185. Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behav Brain Res. 2000 Feb; 108(1):47-56. PMID: 10680756.
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    186. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000 Jan-Feb; 21(1):89-96. PMID: 10794853.
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    187. Cotman CW, Anderson AJ. The brain's microenvironment, early functional loss, and the conversion to Alzheimer's disease. Ann N Y Acad Sci. 2000; 924:112-6. PMID: 11193787.
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    188. Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Neuroscience. 2000; 96(3):495-506. PMID: 10717430.
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    189. Russo-Neustadt AA, Beard RC, Huang YM, Cotman CW. Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience. 2000; 101(2):305-12. PMID: 11074154.
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    190. Russo-Neustadt A, Beard RC, Cotman CW. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 1999 Nov; 21(5):679-82. PMID: 10516964.
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    191. Ivins KJ, Thornton PL, Rohn TT, Cotman CW. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Neurobiol Dis. 1999 Oct; 6(5):440-9. PMID: 10527810.
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    192. Johnson JK, Head E, Kim R, Starr A, Cotman CW. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol. 1999 Oct; 56(10):1233-9. PMID: 10520939.
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    193. Davis J, Cribbs DH, Cotman CW, Van Nostrand WE. Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. Amyloid. 1999 Sep; 6(3):157-64. PMID: 10524279.
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    194. Deng G, Su JH, Ivins KJ, Van Houten B, Cotman CW. Bcl-2 facilitates recovery from DNA damage after oxidative stress. Exp Neurol. 1999 Sep; 159(1):309-18. PMID: 10486199.
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    195. Kim D, Su J, Cotman CW. Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment. Brain Res. 1999 Aug 28; 839(2):253-62. PMID: 10519048.
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    196. Berchtold NC, Oliff HS, Isackson P, Cotman CW. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain Res Mol Brain Res. 1999 Jul 23; 71(1):11-22. PMID: 10407182.
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    197. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Exp Neurol. 1999 Jun; 157(2):277-88. PMID: 10364440.
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    198. Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999 Mar; 72(3):1061-8. PMID: 10037477.
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    199. Ivins KJ, Ivins JK, Sharp JP, Cotman CW. Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid. J Biol Chem. 1999 Jan 22; 274(4):2107-12. PMID: 9890971.
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    200. Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. Landmark discrimination learning in the dog. Learn Mem. 1999 Jan-Feb; 6(1):54-61. PMID: 10355524.
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    201. Johnson JK, Cotman CW, Tasaki CS, Shaw GL. Enhancement of spatial-temporal reasoning after a Mozart listening condition in Alzheimer's disease: a case study. Neurol Res. 1998 Dec; 20(8):666-72. PMID: 9864729.
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    202. Su JH, Cummings BJ, Cotman CW. Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol. 1998 Nov; 96(5):463-71. PMID: 9829809.
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    203. Ivins KJ, Bui ET, Cotman CW. Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis. Neurobiol Dis. 1998 Nov; 5(5):365-78. PMID: 10069579.
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    204. Russo-Neustadt A, Zomorodian TJ, Cotman CW. Preserved cerebellar tyrosine hydroxylase-immunoreactive neuronal fibers in a behaviorally aggressive subgroup of Alzheimer's disease patients. Neuroscience. 1998 Nov; 87(1):55-61. PMID: 9722141.
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    205. Oliff HS, Berchtold NC, Isackson P, Cotman CW. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res Mol Brain Res. 1998 Oct 30; 61(1-2):147-53. PMID: 9795193.
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    206. Torp R, Su JH, Deng G, Cotman CW. GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro. Neurobiol Dis. 1998 Oct; 5(4):245-52. PMID: 9848094.
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    207. Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging. 1998 Sep-Oct; 19(5):479-85. PMID: 9880050.
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    208. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging. 1998 Sep-Oct; 19(5):415-25. PMID: 9880044.
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    209. Eckert A, Cotman CW, Zerfass R, Hennerici M, Müller WE. Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease. Neuroreport. 1998 Aug 03; 9(11):2443-6. PMID: 9721911.
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    210. Sheetz MP, Pfister KK, Bulinski JC, Cotman CW. Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration. Prog Neurobiol. 1998 Aug; 55(6):577-94. PMID: 9670219.
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    211. Cotman CW, Hailer NP, Pfister KK, Soltesz I, Schachner M. Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations? Prog Neurobiol. 1998 Aug; 55(6):659-69. PMID: 9670224.
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    212. Stenger DA, Hickman JJ, Bateman KE, Ravenscroft MS, Ma W, Pancrazio JJ, Shaffer K, Schaffner AE, Cribbs DH, Cotman CW. Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons. J Neurosci Methods. 1998 Aug 01; 82(2):167-73. PMID: 9700689.
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    213. Kesslak JP, So V, Choi J, Cotman CW, Gomez-Pinilla F. Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance? Behav Neurosci. 1998 Aug; 112(4):1012-9. PMID: 9733207.
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    214. Johnson JK, McCleary R, Oshita MH, Cotman CW. Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles. Brain Res. 1998 Jul 06; 798(1-2):18-24. PMID: 9666062.
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    215. Azizeh BY, Cribbs DH, Kreng VM, Cotman CW. Cross-linking of NCAM receptors on neurons induces programmed cell death. Brain Res. 1998 Jun 15; 796(1-2):20-6. PMID: 9689450.
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    216. Balázs R, Miller S, Chun Y, O'Toole J, Cotman CW. Metabotropic glutamate receptor agonists potentiate cyclic AMP formation induced by forskolin or beta-adrenergic receptor activation in cerebral cortical astrocytes in culture. J Neurochem. 1998 Jun; 70(6):2446-58. PMID: 9603209.
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    217. Balázs R, Miller S, Chun Y, Cotman CW. Receptor-coupled phospholipase C and adenylyl cyclase function with different calcium pools in astrocytes. Neuroreport. 1998 May 11; 9(7):1397-401. PMID: 9631436.
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    218. Berchtold NC, Cotman CW. Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s. Neurobiol Aging. 1998 May-Jun; 19(3):173-89. PMID: 9661992.
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    219. Ibrahim MA, Emerson JF, Cotman CW. Magnetic resonance imaging relaxation times and gadolinium-DTPA relaxivity values in human cerebrospinal fluid. Invest Radiol. 1998 Mar; 33(3):153-62. PMID: 9525754.
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    220. Eckert A, Cotman CW, Zerfass R, Hennerici M, Müller WE. Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered. J Neural Transm Suppl. 1998; 54:259-67. PMID: 9850934.
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    221. Cotman CW. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging. 1998 Jan-Feb; 19(1 Suppl):S29-32. PMID: 9562464.
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    222. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 07; 774(1-2):35-43. PMID: 9452189.
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    223. Su JH, Deng G, Cotman CW. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 1997 Nov 07; 774(1-2):193-9. PMID: 9452208.
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    224. Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. Open field activity and human interaction as a function of age and breed in dogs. Physiol Behav. 1997 Nov; 62(5):963-71. PMID: 9333188.
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    225. Pike CJ, Ramezan-Arab N, Cotman CW. Beta-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. J Neurochem. 1997 Oct; 69(4):1601-11. PMID: 9326289.
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    226. de Figueiredo RJ, Oten R, Su J, Cotman CW. Amyloid deposition in cerebrovascular angiopathy. Ann N Y Acad Sci. 1997 Sep 26; 826:463-71. PMID: 9329725.
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    227. Major DE, Kesslak JP, Cotman CW, Finch CE, Day JR. Life-long dietary restriction attenuates age-related increases in hippocampal glial fibrillary acidic protein mRNA. Neurobiol Aging. 1997 Sep-Oct; 18(5):523-6. PMID: 9390779.
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    228. Ulas J, Cotman CW. Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain. Neuroscience. 1997 Aug; 79(4):973-82. PMID: 9219960.
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    229. Russo-Neustadt A, Cotman CW. Adrenergic receptors in Alzheimer's disease brain: selective increases in the cerebella of aggressive patients. J Neurosci. 1997 Jul 15; 17(14):5573-80. PMID: 9204938.
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    230. Donovan FM, Pike CJ, Cotman CW, Cunningham DD. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci. 1997 Jul 15; 17(14):5316-26. PMID: 9204916.
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    231. Balázs R, Miller S, Romano C, de Vries A, Chun Y, Cotman CW. Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation. J Neurochem. 1997 Jul; 69(1):151-63. PMID: 9202306.
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    232. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med. 1997 Apr 24; 336(17):1216-22. PMID: 9110909.
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    233. Cotman CW. The beta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. A new principle in peptide function and the induction of neuropathology. Ann N Y Acad Sci. 1997 Apr 24; 814:1-16. PMID: 9160955.
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    234. Cribbs DH, Pike CJ, Weinstein SL, Velazquez P, Cotman CW. All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids. J Biol Chem. 1997 Mar 14; 272(11):7431-6. PMID: 9054444.
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    235. Su JH, Deng G, Cotman CW. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol. 1997 Jan; 56(1):86-93. PMID: 8990132.
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    236. Gómez-Pinilla F, Miller S, Choi J, Cotman CW. Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study. Neuroscience. 1997 Jan; 76(1):137-45. PMID: 8971766.
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    237. Su JH, Deng G, Cotman CW. Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation. Neurobiol Dis. 1997; 4(5):365-75. PMID: 9440125.
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    238. Nielson KA, Cummings BJ, Cotman CW. Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex. Brain Res. 1996 Nov 25; 741(1-2):284-93. PMID: 9001734.
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    239. Su JH, Cummings BJ, Cotman CW. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res. 1996 Nov 11; 739(1-2):79-87. PMID: 8955927.
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    240. Deng G, Pike CJ, Cotman CW. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 1996 Nov 11; 397(1):50-4. PMID: 8941712.
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    241. Cummings BJ, Pike CJ, Shankle R, Cotman CW. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol Aging. 1996 Nov-Dec; 17(6):921-33. PMID: 9363804.
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    242. Cribbs DH, Kreng VM, Anderson AJ, Cotman CW. Cross-linking of concanavalin A receptors on cortical neurons induces programmed cell death. Neuroscience. 1996 Nov; 75(1):173-85. PMID: 8923532.
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    243. Miller S, Sehati N, Romano C, Cotman CW. Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. J Neurochem. 1996 Oct; 67(4):1435-47. PMID: 8858925.
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    244. Pike CJ, Balázs R, Cotman CW. Attenuation of beta-amyloid neurotoxicity in vitro by potassium-induced depolarization. J Neurochem. 1996 Oct; 67(4):1774-7. PMID: 8858966.
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    245. Cotman CW, Su JH. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 1996 Oct; 6(4):493-506. PMID: 8944319.
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    246. Deng G, Su JH, Cotman CW. Gene expression of Alzheimer-associated presenilin-2 in the frontal cortex of Alzheimer and aged control brain. FEBS Lett. 1996 Sep 23; 394(1):17-20. PMID: 8925918.
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    247. Cotman CW, Tenner AJ, Cummings BJ. beta-Amyloid converts an acute phase injury response to chronic injury responses. Neurobiol Aging. 1996 Sep-Oct; 17(5):723-31. PMID: 8892345.
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    248. Nielson KA, Nolan JH, Berchtold NC, Sandman CA, Mulnard RA, Cotman CW. Apolipoprotein-E genotyping of diabetic dementia patients: is diabetes rare in Alzheimer's disease? J Am Geriatr Soc. 1996 Aug; 44(8):897-904. PMID: 8708297.
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    249. Ulas J, Cotman CW. Dopaminergic denervation of striatum results in elevated expression of NR2A subunit. Neuroreport. 1996 Jul 29; 7(11):1789-93. PMID: 8905666.
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    250. Cribbs DH, Chen LS, Cotman CW, LaFerla FM. Injury induces presenilin-1 gene expression in mouse brain. Neuroreport. 1996 Jul 29; 7(11):1773-6. PMID: 8905662.
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    251. Neeper SA, Gómez-Pinilla F, Choi J, Cotman CW. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 1996 Jul 08; 726(1-2):49-56. PMID: 8836544.
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    252. Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiol Aging. 1996 Jul-Aug; 17(4):653-9. PMID: 8832640.
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    253. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. PMID: 8661247.
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    254. Pike CJ, Ramezan-Arab N, Miller S, Cotman CW. beta-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes. Exp Neurol. 1996 May; 139(1):167-71. PMID: 8635563.
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    255. Pike CJ, Vaughan PJ, Cunningham DD, Cotman CW. Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro. J Neurochem. 1996 Apr; 66(4):1374-82. PMID: 8627288.
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    256. Anderson AJ, Su JH, Cotman CW. DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci. 1996 Mar 01; 16(5):1710-9. PMID: 8774439.
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    257. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. PMID: 8744407.
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    258. Dick MB, Shankle RW, Beth RE, Dick-Muehlke C, Cotman CW, Kean ML. Acquisition and long-term retention of a gross motor skill in Alzheimer's disease patients under constant and varied practice conditions. J Gerontol B Psychol Sci Soc Sci. 1996 Mar; 51(2):P103-11. PMID: 8785686.
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    259. Afagh A, Cummings BJ, Cribbs DH, Cotman CW, Tenner AJ. Localization and cell association of C1q in Alzheimer's disease brain. Exp Neurol. 1996 Mar; 138(1):22-32. PMID: 8593893.
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    260. Su JH, Satou T, Anderson AJ, Cotman CW. Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease. Neuroreport. 1996 Jan 31; 7(2):437-40. PMID: 8730800.
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    261. Cummings BJ, Cotman CW. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet. 1995 Dec 09; 346(8989):1524-8. PMID: 7491048.
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    262. Dick MB, Nielson KA, Beth RE, Shankle WR, Cotman CW. Acquisition and long-term retention of a fine motor skill in Alzheimer's disease. Brain Cogn. 1995 Dec; 29(3):294-306. PMID: 8838387.
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    263. Satou T, Cummings BJ, Cotman CW. Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res. 1995 Oct 30; 697(1-2):35-43. PMID: 8593592.
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    264. Woods AG, Cribbs DH, Whittemore ER, Cotman CW. Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons. Brain Res. 1995 Oct 30; 697(1-2):53-62. PMID: 8593595.
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    265. Pike CJ, Overman MJ, Cotman CW. Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. J Biol Chem. 1995 Oct 13; 270(41):23895-8. PMID: 7592576.
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    266. Anderson AJ, Pike CJ, Cotman CW. Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. J Neurochem. 1995 Oct; 65(4):1487-98. PMID: 7561842.
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    267. Loo DT, Althoen MC, Cotman CW. Differentiation of serum-free mouse embryo cells into astrocytes is accompanied by induction of glutamine synthetase activity. J Neurosci Res. 1995 Oct 01; 42(2):184-91. PMID: 8568918.
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    268. Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cotman CW, Ruehl WW, Milgram NW. Spatial learning and memory as a function of age in the dog. Behav Neurosci. 1995 Oct; 109(5):851-8. PMID: 8554710.
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    269. Miller S, Romano C, Cotman CW. Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes. J Neurosci. 1995 Sep; 15(9):6103-9. PMID: 7666194.
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    270. Whittemore ER, Loo DT, Watt JA, Cotman CW. A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. Neuroscience. 1995 Aug; 67(4):921-32. PMID: 7675214.
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    271. Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Nostrand WE. Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J Neurochem. 1995 Aug; 65(2):931-4. PMID: 7616257.
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    272. Korotzer AR, Watt J, Cribbs D, Tenner AJ, Burdick D, Glabe C, Cotman CW. Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia. Exp Neurol. 1995 Aug; 134(2):214-21. PMID: 7556541.
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    273. Vaughan PJ, Pike CJ, Cotman CW, Cunningham DD. Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci. 1995 Jul; 15(7 Pt 2):5389-401. PMID: 7623161.
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    274. Choi BH, Kim RC, Vaughan PJ, Lau A, Van Nostrand WE, Cotman CW, Cunningham DD. Decreases in protease nexins in Alzheimer's disease brain. Neurobiol Aging. 1995 Jul-Aug; 16(4):557-62. PMID: 8544905.
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    275. deFigueiredo RJ, Shankle WR, Maccato A, Dick MB, Mundkur P, Mena I, Cotman CW. Neural-network-based classification of cognitively normal, demented, Alzheimer disease and vascular dementia from single photon emission with computed tomography image data from brain. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5530-4. PMID: 7777543.
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    276. Araujo DM, Cotman CW. Differential effects of interleukin-1 beta and interleukin-2 on glia and hippocampal neurons in culture. Int J Dev Neurosci. 1995 Jun-Jul; 13(3-4):201-12. PMID: 7572276.
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    277. Gómez-Pinilla F, van der Wal EA, Cotman CW. Possible coordinated gene expressions for FGF receptor, FGF-5, and FGF-2 following seizures. Exp Neurol. 1995 Jun; 133(2):164-74. PMID: 7649223.
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    278. Miller S, Kesslak JP, Romano C, Cotman CW. Roles of metabotropic glutamate receptors in brain plasticity and pathology. Ann N Y Acad Sci. 1995 May 10; 757:460-74. PMID: 7611703.
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    279. Pike CJ, Cummings BJ, Cotman CW. Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Exp Neurol. 1995 Apr; 132(2):172-9. PMID: 7789457.
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    280. Kesslak JP, Yuan D, Neeper S, Cotman CW. Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat. Neurosci Lett. 1995 Mar 24; 188(2):117-20. PMID: 7792054.
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    281. Defigueiredo RJ, Cummings BJ, Mundkur PY, Cotman CW. Color image analysis in neuroanatomical research: application to senile plaque subtype quantification in Alzheimer's disease. Neurobiol Aging. 1995 Mar-Apr; 16(2):211-23. PMID: 7777139.
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    282. Gómez-Pinilla F, Vu L, Cotman CW. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar; 15(3 Pt 1):2021-9. PMID: 7891149.
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    283. Pike CJ, Cotman CW. Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro. Brain Res. 1995 Feb 13; 671(2):293-8. PMID: 7743217.
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    284. Cotman CW, Anderson AJ. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol. 1995 Feb; 10(1):19-45. PMID: 7598831.
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    285. Korotzer AR, Whittemore ER, Cotman CW. Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia. Eur J Pharmacol. 1995 Jan 16; 288(2):125-30. PMID: 7720773.
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    286. Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Prog Brain Res. 1995; 106:217-25. PMID: 8584657.
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    287. Shankle WR, Nielson KA, Cotman CW. Low-dose propranolol reduces aggression and agitation resembling that associated with orbitofrontal dysfunction in elderly demented patients. Alzheimer Dis Assoc Disord. 1995; 9(4):233-7. PMID: 8749613.
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    288. Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, Cotman CW. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. J Neurochem. 1995 Jan; 64(1):253-65. PMID: 7798921.
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    289. Vaughan PJ, Su J, Cotman CW, Cunningham DD. Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease. Brain Res. 1994 Dec 30; 668(1-2):160-70. PMID: 7704602.
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    290. Su JH, Anderson AJ, Cummings BJ, Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport. 1994 Dec 20; 5(18):2529-33. PMID: 7696596.
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    291. Cotman CW, Whittemore ER, Watt JA, Anderson AJ, Loo DT. Possible role of apoptosis in Alzheimer's disease. Ann N Y Acad Sci. 1994 Dec 15; 747:36-49. PMID: 7847684.
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    292. Su JH, Cummings BJ, Cotman CW. Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. Neuroreport. 1994 Nov 21; 5(17):2358-62. PMID: 7533559.
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    293. Pike CJ, Cummings BJ, Monzavi R, Cotman CW. Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. Neuroscience. 1994 Nov; 63(2):517-31. PMID: 7891862.
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    294. Ulas J, Weihmuller FB, Brunner LC, Joyce JN, Marshall JF, Cotman CW. Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study. J Neurosci. 1994 Nov; 14(11 Pt 1):6317-24. PMID: 7965038.
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    295. Watt JA, Pike CJ, Walencewicz-Wasserman AJ, Cotman CW. Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res. 1994 Oct 24; 661(1-2):147-56. PMID: 7834365.
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    296. Miller S, Bridges RJ, Chamberlin AR, Cotman CW. Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes. Eur J Pharmacol. 1994 Oct 14; 269(2):235-41. PMID: 7851499.
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    297. Smyth MD, Cribbs DH, Tenner AJ, Shankle WR, Dick M, Kesslak JP, Cotman CW. Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state. Neurobiol Aging. 1994 Sep-Oct; 15(5):609-14. PMID: 7824052.
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    298. Loo DT, Althoen MC, Cotman CW. Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes. Neuroreport. 1994 Aug 15; 5(13):1585-8. PMID: 7529590.
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    299. Gómez-Pinilla F, Lee JW, Cotman CW. Distribution of basic fibroblast growth factor in the developing rat brain. Neuroscience. 1994 Aug; 61(4):911-23. PMID: 7838387.
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    300. Whittemore ER, Loo DT, Cotman CW. Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons. Neuroreport. 1994 Jul 21; 5(12):1485-8. PMID: 7948844.
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    301. Bridges RJ, Lovering FE, Koch H, Cotman CW, Chamberlin AR. A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine dicarboxylate. Neurosci Lett. 1994 Jun 20; 174(2):193-7. PMID: 7970177.
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    302. Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol. 1994 May 15; 152(10):5050-9. PMID: 8176223.
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    303. Van Der Wal EA, Gómez-Pinilla F, Cotman CW. Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain. Neuroscience. 1994 May; 60(2):311-23. PMID: 8072686.
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    304. Smyth MD, Kesslak JP, Cummings BJ, Cotman CW. Analysis of brain injury following intrahippocampal administration of beta-amyloid in streptozotocin-treated rats. Neurobiol Aging. 1994 Mar-Apr; 15(2):153-9. PMID: 7838285.
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    305. Su JH, Cummings BJ, Cotman CW. Subpopulations of dystrophic neurites [correction of neuritis] in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics. Brain Res. 1994 Feb 21; 637(1-2):37-44. PMID: 8180819.
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    306. Anderson AJ, Cummings BJ, Cotman CW. Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology. Exp Neurol. 1994 Feb; 125(2):286-95. PMID: 8313943.
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    307. Cotman CW. Report of Alzheimer's disease Working Group A. Neurobiol Aging. 1994; 15 Suppl 2:S17-22. PMID: 7700445.
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    308. Weiss JH, Pike CJ, Cotman CW. Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. J Neurochem. 1994 Jan; 62(1):372-5. PMID: 8263540.
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    309. Stenger DA, Pike CJ, Hickman JJ, Cotman CW. Surface determinants of neuronal survival and growth on self-assembled monolayers in culture. Brain Res. 1993 Dec 10; 630(1-2):136-47. PMID: 8118680.
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    310. Cummings BJ, Su JH, Cotman CW. Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease. Exp Neurol. 1993 Dec; 124(2):315-25. PMID: 8287930.
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    311. Kahle JS, Cotman CW. Synaptic reorganization in the hippocampus: an electrophysiological analysis. Ann N Y Acad Sci. 1993 Nov 17; 702:61-74. PMID: 8109878.
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    312. Cummings BJ, Su JH, Cotman CW, White R, Russell MJ. Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease. Neurobiol Aging. 1993 Nov-Dec; 14(6):547-60. PMID: 8295657.
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    313. Wagner SL, Van Nostrand WE, Lau AL, Farrow JS, Suzuki M, Bartus RT, Schuppek R, Nguyen A, Cotman CW, Cunningham DD. Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates. Brain Res. 1993 Oct 29; 626(1-2):90-8. PMID: 8281456.
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    314. Su JH, Cummings BJ, Cotman CW. Identification and distribution of axonal dystrophic neurites in Alzheimer's disease. Brain Res. 1993 Oct 22; 625(2):228-37. PMID: 8275305.
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    315. Korotzer AR, Pike CJ, Cotman CW. beta-Amyloid peptides induce degeneration of cultured rat microglia. Brain Res. 1993 Oct 08; 624(1-2):121-5. PMID: 8252383.
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    316. Whittemore ER, Korotzer AR, Etebari A, Cotman CW. Carbachol increases intracellular free calcium in cultured rat microglia. Brain Res. 1993 Sep 03; 621(1):59-64. PMID: 8106116.
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    317. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):7951-5. PMID: 8367446.
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    318. Pike CJ, Cotman CW. Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid. Neuroscience. 1993 Sep; 56(2):269-74. PMID: 8247260.
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    319. Ulas J, Nguyen L, Cotman CW. Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. Neuroreport. 1993 Aug; 4(8):1049-51. PMID: 7902135.
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    320. Miller S, Bridges RJ, Cotman CW. Stimulation of phosphoinositide hydrolysis by trans-(+/-)-ACPD is greatly enhanced when astrocytes are cultured in a serum-free defined medium. Brain Res. 1993 Jul 30; 618(1):175-8. PMID: 8402173.
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    321. Kahle JS, Cotman CW. L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices. J Pharmacol Exp Ther. 1993 Jul; 266(1):207-15. PMID: 8101217.
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    322. Magnusson KR, Cotman CW. Age-related changes in excitatory amino acid receptors in two mouse strains. Neurobiol Aging. 1993 May-Jun; 14(3):197-206. PMID: 8391661.
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    323. Kahle JS, Ulas J, Cotman CW. Increased sensitivity to adenosine in the rat dentate gyrus molecular layer two weeks after partial entorhinal lesions. Brain Res. 1993 Apr 23; 609(1-2):201-10. PMID: 8508304.
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    324. Vijayan VK, Zhou SS, Russell MJ, Geddes J, Ellis W, Cotman CW. Perineuronal satellitosis in the human hippocampal formation. Hippocampus. 1993 Apr; 3(2):239-50. PMID: 8353607.
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    325. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci. 1993 Apr; 13(4):1676-87. PMID: 8463843.
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    326. Gómez-Pinilla F, Cotman CW. Distribution of fibroblast growth factor 5 mRNA in the rat brain: an in situ hybridization study. Brain Res. 1993 Mar 19; 606(1):79-86. PMID: 8462006.
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    327. Russell MJ, Cummings BJ, Profitt BF, Wysocki CJ, Gilbert AN, Cotman CW. Life span changes in the verbal categorization of odors. J Gerontol. 1993 Mar; 48(2):P49-53. PMID: 8473697.
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    328. Magnusson KR, Cotman CW. Effects of aging on NMDA and MK801 binding sites in mice. Brain Res. 1993 Feb 26; 604(1-2):334-7. PMID: 8457861.
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    329. Ulas J, Brunner LC, Nguyen L, Cotman CW. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience. 1993 Feb; 52(4):843-54. PMID: 8450977.
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    330. Araujo DM, Cotman CW. Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors. Brain Res. 1993 Jan 08; 600(1):49-55. PMID: 8422590.
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    331. Kahle JS, Cotman CW. Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: interstimulus interval-dependent pharmacology. Exp Brain Res. 1993; 94(1):97-104. PMID: 8392942.
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    332. Cotman CW, Pike CJ, Cummings BJ. Adaptive versus pathological plasticity. Possible contributions to age-related dementia. Adv Neurol. 1993; 59:35-45. PMID: 8420121.
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    333. van der Wal EA, Gómez-Pinilla F, Cotman CW. Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport. 1993 Jan; 4(1):69-72. PMID: 8453039.
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    334. Neal JH, Cotman CW. Human brain tumor cyst fluid is mitogenic for primary astrocytes in culture. Neurosurgery. 1993 Jan; 32(1):95-8; discussion 98-9. PMID: 8421562.
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    335. Ulas J, Cotman CW. Excitatory amino acid receptors in schizophrenia. Schizophr Bull. 1993; 19(1):105-17. PMID: 8383875.
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    336. Su JH, Cummings BJ, Cotman CW. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience. 1992 Dec; 51(4):801-13. PMID: 1488123.
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    337. Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegón M, Cotman C, Vaught JL, Neve RL. Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10857-61. PMID: 1438289.
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    338. Weihmuller FB, Ulas J, Nguyen L, Cotman CW, Marshall JF. Elevated NMDA receptors in parkinsonian striatum. Neuroreport. 1992 Nov; 3(11):977-80. PMID: 1482768.
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    339. Cummings BJ, Yee GJ, Cotman CW. bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy. Brain Res. 1992 Sep 25; 591(2):271-6. PMID: 1446240.
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    340. Cotman CW, Pike CJ, Copani A. beta-Amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol Aging. 1992 Sep-Oct; 13(5):587-90. PMID: 1461347.
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    341. Pike CJ, Cummings BJ, Cotman CW. beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. Neuroreport. 1992 Sep; 3(9):769-72. PMID: 1421135.
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    342. Geddes JW, Ulas J, Brunner LC, Choe W, Cotman CW. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience. 1992 Sep; 50(1):23-34. PMID: 1328933.
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    343. Bridges RJ, Hatalski CG, Shim SN, Cummings BJ, Vijayan V, Kundi A, Cotman CW. Gliotoxic actions of excitatory amino acids. Neuropharmacology. 1992 Sep; 31(9):899-907. PMID: 1436396.
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    344. Koh JY, Cotman CW. Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists. Brain Res. 1992 Aug 07; 587(2):233-40. PMID: 1525659.
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    345. Gómez-Pinilla F, Cotman CW. Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex. Neuroscience. 1992 Aug; 49(4):771-80. PMID: 1436480.
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    346. Clark AS, Cotman CW. Adrenal hormone effects on hippocampal excitatory amino acid binding. Brain Res. 1992 Jul 10; 585(1-2):161-8. PMID: 1355001.
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    347. Ulas J, Brunner LC, Geddes JW, Choe W, Cotman CW. N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease. Neuroscience. 1992 Jul; 49(1):45-61. PMID: 1407551.
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    348. Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 1992 Jun; 48(4):763-77. PMID: 1378573.
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    349. Miller S, Cotman CW, Bridges RJ. 1-Aminocyclopentane-trans-1,3-dicarboxylic acid induces glutamine synthetase activity in cultured astrocytes. J Neurochem. 1992 May; 58(5):1967-70. PMID: 1348527.
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    350. Araujo DM, Cotman CW. Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors. J Neurosci. 1992 May; 12(5):1668-78. PMID: 1578261.
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    351. Clark AS, Magnusson KR, Cotman CW. In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: relationship to performance on the Morris water maze. Behav Neurosci. 1992 Apr; 106(2):324-35. PMID: 1317185.
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    352. Van Nostrand WE, Wagner SL, Shankle WR, Farrow JS, Dick M, Rozemuller JM, Kuiper MA, Wolters EC, Zimmerman J, Cotman CW. Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2551-5. PMID: 1557359.
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    353. Taube JS, Kesslak JP, Cotman CW. Lesions of the rat postsubiculum impair performance on spatial tasks. Behav Neural Biol. 1992 Mar; 57(2):131-43. PMID: 1586352.
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    354. Geddes JW, Brunner L, Cotman CW, Buzsáki G. Alterations in [3H]kainate and N-methyl-D-aspartate-sensitive L-[3H]-glutamate binding in the rat hippocampal formation following fimbria-fornix lesions. Exp Neurol. 1992 Feb; 115(2):271-81. PMID: 1310474.
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    355. Emerich DF, Black BA, Kesslak JP, Cotman CW, Walsh TJ. Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A. Brain Res Bull. 1992 Feb; 28(2):219-26. PMID: 1596741.
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    356. Araujo DM, Cotman CW. Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res. 1992 Jan 08; 569(1):141-5. PMID: 1611474.
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    357. Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem. 1992 Jan 05; 267(1):546-54. PMID: 1730616.
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    358. Korotzer AR, Cotman CW. Voltage-gated currents expressed by rat microglia in culture. Glia. 1992; 6(2):81-8. PMID: 1328052.
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    359. Cotman CW. An overview and perspective on the potential relevance of neuronal growth to the development of epilepsy and epilepsy-related disturbances. Epilepsy Res Suppl. 1992; 9:257-61; discussion 261-4. PMID: 1285909.
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    360. Gómez-Pinilla F, Lee JW, Cotman CW. Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection. J Neurosci. 1992 Jan; 12(1):345-55. PMID: 1309575.
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    361. Copani A, Koh JY, Cotman CW. Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation. Neuroreport. 1991 Dec; 2(12):763-5. PMID: 1793819.
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    362. Van Nostrand WE, Farrow JS, Wagner SL, Bhasin R, Goldgaber D, Cotman CW, Cunningham DD. The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10302-6. PMID: 1946448.
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    363. Koh JY, Palmer E, Cotman CW. Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9431-5. PMID: 1658782.
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    364. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 1991 Nov 01; 563(1-2):311-4. PMID: 1786545.
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    365. Anderson KJ, Bridges RJ, Cotman CW. Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion. Brain Res. 1991 Oct 25; 562(2):285-90. PMID: 1685344.
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    366. Koh JY, Palmer E, Lin A, Cotman CW. A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture. Brain Res. 1991 Oct 11; 561(2):338-43. PMID: 1666330.
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    367. Buchsbaum MS, Kesslak JP, Lynch G, Chui H, Wu J, Sicotte N, Hazlett E, Teng E, Cotman CW. Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controls. Preliminary studies. Arch Gen Psychiatry. 1991 Sep; 48(9):840-7. PMID: 1929775.
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    368. Stevens DR, Cotman CW. Long-term potentiation of excitatory and slow inhibitory synaptic potentials in the hippocampal-septal projection of the rat. Brain Res. 1991 Aug 30; 558(1):120-2. PMID: 1657309.
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    369. Kesslak JP, Korotzer A, Song A, Kamali K, Cotman CW. Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex. Brain Res. 1991 Aug 23; 557(1-2):57-63. PMID: 1747769.
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    370. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol. 1991 Aug 14; 207(4):367-8. PMID: 1783006.
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    371. Whittemore ER, Cotman CW. Agonists selective for phosphoinositide-coupled receptors sensitize neurons to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4). Brain Res. 1991 Aug 02; 555(2):215-9. PMID: 1681998.
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    372. Geddes JW, Cotman CW. Plasticity in Alzheimer's disease: too much or not enough? Neurobiol Aging. 1991 Jul-Aug; 12(4):330-3; discussion 352-5. PMID: 1961362.
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    373. Vijayan VK, Geddes JW, Anderson KJ, Chang-Chui H, Ellis WG, Cotman CW. Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation. Exp Neurol. 1991 Apr; 112(1):72-8. PMID: 2013308.
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    374. Sullivan RM, Taborsky-Barba S, Mendoza R, Itano A, Leon M, Cotman CW, Payne TF, Lott I. Olfactory classical conditioning in neonates. Pediatrics. 1991 Apr; 87(4):511-8. PMID: 2011429.
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    375. Bridges RJ, Stanley MS, Anderson MW, Cotman CW, Chamberlin AR. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J Med Chem. 1991 Feb; 34(2):717-25. PMID: 1671706.
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    376. Bridges RJ, Koh JY, Hatalski CG, Cotman CW. Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione. Eur J Pharmacol. 1991 Jan 03; 192(1):199-200. PMID: 1674918.
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    377. Peterson C, Vanderklish P, Seubert P, Cotman C, Lynch G. Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors. Neurosci Lett. 1991 Jan 02; 121(1-2):239-43. PMID: 2020380.
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    378. Kesslak JP, Nalcioglu O, Cotman CW. Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease. Neurology. 1991 Jan; 41(1):51-4. PMID: 1985296.
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    379. Cotman CW, Gómez-Pinilla F. Basic fibroblast growth factor in the mature brain and its possible role in Alzheimer's disease. Ann N Y Acad Sci. 1991; 638:221-31. PMID: 1785803.
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    380. Koh JY, Yang LL, Cotman CW. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 1990 Nov 19; 533(2):315-20. PMID: 2289145.
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    381. Gómez-Pinilla F, Cummings BJ, Cotman CW. Induction of basic fibroblast growth factor in Alzheimer's disease pathology. Neuroreport. 1990 Nov-Dec; 1(3-4):211-4. PMID: 1717039.
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    382. Peterson C, Giguere JF, Cotman CW, Butterworth RF. Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis. J Neurochem. 1990 Aug; 55(2):386-90. PMID: 1973453.
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    383. Ulas J, Monaghan DT, Cotman CW. Kainate receptors in the rat hippocampus: a distribution and time course of changes in response to unilateral lesions of the entorhinal cortex. J Neurosci. 1990 Jul; 10(7):2352-62. PMID: 2165522.
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    384. Borg J, Kesslak PJ, Cotman CW. Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection. Brain Res. 1990 Jun 04; 518(1-2):295-8. PMID: 2390721.
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    385. Geddes JW, Cahan LD, Cooper SM, Kim RC, Choi BH, Cotman CW. Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy. Exp Neurol. 1990 Jun; 108(3):214-20. PMID: 2161774.
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    386. Peterson C, Cotman CW. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain Res. 1990 May 07; 515(1-2):39-44. PMID: 2357575.
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    387. Russell MJ, Vijayan VK, Gibbs RB, Geddes JW, Jacobson CH, Cotman CW. Long-term survival of neural transplants to senescence in rats. Exp Neurol. 1990 May; 108(2):105-8. PMID: 2335191.
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    388. Baudry M, Monaghan D, Cotman C, Altar CA. Regional distribution of alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding sites in rat brain: effect of chemical modification of SH- groups in tissue sections. J Neurochem. 1990 May; 54(5):1682-8. PMID: 2157815.
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    389. Whitson JS, Glabe CG, Shintani E, Abcar A, Cotman CW. Beta-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci Lett. 1990 Mar 14; 110(3):319-24. PMID: 2183090.
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    390. Geddes JW, Wong J, Choi BH, Kim RC, Cotman CW, Miller FD. Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease. Neurosci Lett. 1990 Feb 05; 109(1-2):54-61. PMID: 2314641.
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    391. Seubert P, Peterson C, Vanderklish P, Cotman C, Lynch G. Increased spectrin proteolysis in the brindled mouse brain. Neurosci Lett. 1990 Jan 22; 108(3):303-8. PMID: 2304649.
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    392. Cotman CW, Geddes JW, Kahle JS. Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms? Prog Brain Res. 1990; 83:427-34. PMID: 2203106.
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    393. Ulas J, Monaghan DT, Cotman CW. Plastic response of hippocampal excitatory amino acid receptors to deafferentation and reinnervation. Neuroscience. 1990; 34(1):9-17. PMID: 2158009.
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    394. Cahan LD, Geddes JW, Choi BH, Cotman C. Excitotoxic amino acid receptors in human complex partial epilepsy. Stereotact Funct Neurosurg. 1990; 54-55:21-4. PMID: 1964242.
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    395. Cotman CW, Geddes JW, Ulas J, Klein M. Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease. Prog Brain Res. 1990; 86:55-61. PMID: 1965056.
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    396. Geddes JW, Hess EJ, Hart RA, Kesslak JP, Cotman CW, Wilson MC. Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker. Neuroscience. 1990; 38(2):515-25. PMID: 1702194.
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    397. Anderson KJ, Monaghan DT, Bridges RJ, Tavoularis AL, Cotman CW. Autoradiographic characterization of putative excitatory amino acid transport sites. Neuroscience. 1990; 38(2):311-22. PMID: 1979852.
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    398. Geddes JW, Wilson MC, Miller FD, Cotman CW. Molecular markers of reactive plasticity. Adv Exp Med Biol. 1990; 268:425-32. PMID: 2075860.
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    399. Palmer E, Nangel-Taylor K, Krause JD, Roxas A, Cotman CW. Changes in excitatory amino acid modulation of phosphoinositide metabolism during development. Brain Res Dev Brain Res. 1990 Jan 01; 51(1):132-4. PMID: 2153480.
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    400. Cotman CW, Lynch GS. The neurobiology of learning and memory. Cognition. 1989 Nov; 33(1-2):201-41. PMID: 2691183.
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    401. Wagner SL, Geddes JW, Cotman CW, Lau AL, Gurwitz D, Isackson PJ, Cunningham DD. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8284-8. PMID: 2813392.
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    402. Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature. 1989 Oct 12; 341(6242):546-9. PMID: 2507928.
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    403. Peterson C, Cotman CW. Strain-dependent decrease in glutamate binding to the N-methyl-D-aspartic acid receptor during aging. Neurosci Lett. 1989 Oct 09; 104(3):309-13. PMID: 2573018.
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    404. Cotman CW, Geddes JW, Bridges RJ, Monaghan DT. N-methyl-D-aspartate receptors and Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):603-5; discussion 618-20. PMID: 2572983.
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    405. Geddes JW, Cotman CW. Plasticity, pathology, and Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):571-3; discussion 588-90. PMID: 2812229.
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    406. Brewer GJ, Cotman CW. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res. 1989 Aug 07; 494(1):65-74. PMID: 2765923.
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    407. Palmer E, Monaghan DT, Cotman CW. Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor. Eur J Pharmacol. 1989 Aug 03; 166(3):585-7. PMID: 2553440.
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    408. Joyce JN, Gibbs RB, Cotman CW, Marshall JF. Regulation of muscarinic receptors in hippocampus following cholinergic denervation and reinnervation by septal and striatal transplants. J Neurosci. 1989 Aug; 9(8):2776-91. PMID: 2769366.
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    409. Peterson C, Neal JH, Cotman CW. Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons. Brain Res Dev Brain Res. 1989 Aug 01; 48(2):187-95. PMID: 2673575.
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    410. Balázs R, Hack N, Jørgensen OS, Cotman CW. N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. Neurosci Lett. 1989 Jul 03; 101(3):241-6. PMID: 2549463.
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    411. Bridges RJ, Stevens DR, Kahle JS, Nunn PB, Kadri M, Cotman CW. Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist. J Neurosci. 1989 Jun; 9(6):2073-9. PMID: 2542485.
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    412. Brewer GJ, Cotman CW. NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons. Neurosci Lett. 1989 May 08; 99(3):268-73. PMID: 2566963.
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    413. Gómez-Pinilla F, Tram H, Cotman CW, Nieto-Sampedro M. Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury. Exp Neurol. 1989 May; 104(2):118-24. PMID: 2651138.
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    414. Whitson JS, Selkoe DJ, Cotman CW. Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science. 1989 Mar 17; 243(4897):1488-90. PMID: 2928783.
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    415. Kahle JS, Cotman CW. Carbachol depresses synaptic responses in the medial but not the lateral perforant path. Brain Res. 1989 Mar 13; 482(1):159-63. PMID: 2706473.
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    416. Westerberg E, Monaghan DT, Kalimo H, Cotman CW, Wieloch TW. Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia. J Neurosci. 1989 Mar; 9(3):798-805. PMID: 2538582.
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    417. Gómez-Pinilla F, Cotman CW, Nieto-Sampedro M. NGF receptor immunoreactivity in aged rat brain. Brain Res. 1989 Feb 13; 479(2):255-62. PMID: 2538208.
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    418. Monaghan DT, Bridges RJ, Cotman CW. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol. 1989; 29:365-402. PMID: 2543272.
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    419. Cotman C, Monaghan D. Multiple excitatory amino acid receptor regulation of intracellular Ca2+. Implications for aging and Alzheimer's disease. Ann N Y Acad Sci. 1989; 568:138-48. PMID: 2560895.
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    420. Geddes JW, Cooper SM, Cotman CW, Patel S, Meldrum BS. N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio). Neuroscience. 1989; 32(1):39-47. PMID: 2573860.
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    421. Monaghan DT, Olverman HJ, Nguyen L, Watkins JC, Cotman CW. Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9836-40. PMID: 2904680.
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    422. Palmer E, Monaghan DT, Cotman CW. Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation. Brain Res. 1988 Sep; 464(2):161-5. PMID: 2905924.
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    423. Kesslak JP, Cotman CW, Chui HC, Van den Noort S, Fang H, Pfeffer R, Lynch G. Olfactory tests as possible probes for detecting and monitoring Alzheimer's disease. Neurobiol Aging. 1988 Jul-Aug; 9(4):399-403. PMID: 3185859.
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    424. Kesslak JP, Walencewicz A, Calin L, Nieto-Sampedro M, Cotman CW. Hippocampal but not astrocyte transplants enhance recovery on a forced choice alternation task after kainate lesions. Brain Res. 1988 Jun 28; 454(1-2):347-54. PMID: 3409018.
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    425. Lasher RS, Erickson PF, Mena EE, Cotman CW. The binding of a monoclonal antibody reactive with pp60v-src to the rat CNS both in vitro and in vivo: evidence that the epitope is present intracellularly as well as being associated with a number of antigenically related polypeptides located externally in the plasma membrane only in the synaptic region. Brain Res. 1988 Jun 14; 452(1-2):184-202. PMID: 2456825.
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    426. Nieto-Sampedro M, Lim R, Hicklin DJ, Cotman CW. Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury. Neurosci Lett. 1988 Apr 12; 86(3):361-5. PMID: 3380328.
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    427. Lincoln J, Coopersmith R, Harris EW, Cotman CW, Leon M. NMDA receptor activation and early olfactory learning. Brain Res. 1988 Apr 01; 467(2):309-12. PMID: 2897868.
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    428. Anderson KJ, Gibbs RB, Cotman CW. Transmitter phenotype is a major determinant in the specificity of synapses formed by cholinergic neurons transplanted to the hippocampus. Neuroscience. 1988 Apr; 25(1):19-25. PMID: 2899304.
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    429. Anderson KJ, Dam D, Lee S, Cotman CW. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo. Nature. 1988 Mar 24; 332(6162):360-1. PMID: 3352734.
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    430. Millaruelo AI, Nieto-Sampedro M, Cotman CW. Cooperation between nerve growth factor and laminin or fibronectin in promoting sensory neuron survival and neurite outgrowth. Brain Res. 1988 Feb 01; 466(2):219-28. PMID: 3359313.
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    431. Bridges RJ, Kadri MM, Monaghan DT, Nunn PB, Watkins JC, Cotman CW. Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. Eur J Pharmacol. 1988 Jan 19; 145(3):357-9. PMID: 2895006.
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    432. Cotman CW, Monaghan DT, Ganong AH. Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. Annu Rev Neurosci. 1988; 11:61-80. PMID: 2452598.
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    433. Joyce JN, Gibbs RB, Cotman CW, Marshall JF. Regulation of acetylcholine muscarinic receptors by embryonic septal grafts showing cholinergic innervation of host hippocampus. Prog Brain Res. 1988; 78:109-16. PMID: 3247416.
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    434. Cotman CW, Kesslak JP. The role of trophic factors in behavioral recovery and integration of transplants. Prog Brain Res. 1988; 78:311-9. PMID: 3073414.
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    435. Cotman CW, Anderson KJ. Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease. Adv Neurol. 1988; 47:313-35. PMID: 3278521.
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    436. Gomez-Pinilla F, Cotman CW, Nieto-Sampedro M. NGF receptor immunoreactivity in rat brain: topographic distribution and response to entorhinal ablation. Neurosci Lett. 1987 Dec 04; 82(3):260-6. PMID: 2827075.
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    437. Needels DL, Nieto-Sampedro M, Cotman CW. Long-term support by injured brain extract of a subpopulation of ciliary ganglion neurons purified by differential adhesion. Neurochem Res. 1987 Oct; 12(10):901-7. PMID: 3683740.
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    438. Gibbs RB, Yu J, Cotman CW. Entorhinal transplants and spatial memory abilities in rats. Behav Brain Res. 1987 Oct; 26(1):29-35. PMID: 3675832.
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    439. Stevens DR, Cotman CW. Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons. Neurosci Lett. 1987 Aug 31; 79(3):301-5. PMID: 3658222.
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    440. Harris EW, Stevens DR, Cotman CW. Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site. Brain Res. 1987 Aug 25; 418(2):361-5. PMID: 2890405.
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    441. Bridges RJ, Kesslak JP, Nieto-Sampedro M, Broderick JT, Yu J, Cotman CW. A L-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes. Brain Res. 1987 Jul 07; 415(1):163-8. PMID: 2887242.
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    442. Rosenblatt DE, Cotman CW, Nieto-Sampedro M, Rowe JW, Knauer DJ. Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I. Brain Res. 1987 Jul 07; 415(1):40-8. PMID: 3040175.
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    443. Bridges RJ, Nieto-Sampedro M, Kadri M, Cotman CW. A novel chloride-dependent L-[3H]glutamate binding site in astrocyte membranes. J Neurochem. 1987 Jun; 48(6):1709-15. PMID: 2883255.
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    444. Gibbs RB, Cotman CW. Factors affecting survival and outgrowth from transplants of entorhinal cortex. Neuroscience. 1987 Jun; 21(3):699-706. PMID: 3627432.
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    445. Anderson KJ, Borja MA, Cotman CW, Moffett JR, Namboodiri MA, Neale JH. N-acetylaspartylglutamate identified in the rat retinal ganglion cells and their projections in the brain. Brain Res. 1987 May 12; 411(1):172-7. PMID: 3300843.
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    446. Vijayan VK, Cotman CW. Hydrocortisone administration alters glial reaction to entorhinal lesion in the rat dentate gyrus. Exp Neurol. 1987 May; 96(2):307-20. PMID: 3569457.
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    447. Monaghan DT, Geddes JW, Yao D, Chung C, Cotman CW. [3H]TCP binding sites in Alzheimer's disease. Neurosci Lett. 1987 Jan 14; 73(2):197-200. PMID: 3029638.
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    448. Westerberg E, Monaghan DT, Cotman CW, Wieloch T. Excitatory amino acid receptors and ischemic brain damage in the rat. Neurosci Lett. 1987 Jan 14; 73(2):119-24. PMID: 2881232.
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    449. Nieto-Sampedro M, Kesslak JP, Gibbs R, Cotman CW. Effects of conditioning lesions on transplant survival, connectivity, and function. Role of neurotrophic factors. Ann N Y Acad Sci. 1987; 495:108-19. PMID: 2440364.
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    450. Pixley SK, Nieto-Sampedro M, Cotman CW. Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes. J Neurosci Res. 1987; 18(3):402-6. PMID: 3437463.
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    451. Gibbs RB, Needels DL, Yu J, Cotman CW. Effects of entorhinal lesions on trophic activities present in rat entorhinal cortex and hippocampus as studied using primary cultures of entorhinal and septal tissues. J Neurosci Res. 1987; 18(2):274-88. PMID: 3694710.
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    452. Geddes JW, Chang-Chui H, Cooper SM, Lott IT, Cotman CW. Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease. Brain Res. 1986 Dec 03; 399(1):156-61. PMID: 2879613.
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    453. Anderson KJ, Monaghan DT, Cangro CB, Namboodiri MA, Neale JH, Cotman CW. Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain. Neurosci Lett. 1986 Dec 03; 72(1):14-20. PMID: 3543748.
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    454. Kesslak JP, Brown L, Steichen C, Cotman CW. Adult and embryonic frontal cortex transplants after frontal cortex ablation enhance recovery on a reinforced alternation task. Exp Neurol. 1986 Dec; 94(3):615-26. PMID: 3780910.
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    455. Geddes JW, Anderson KJ, Cotman CW. Senile plaques as aberrant sprout-stimulating structures. Exp Neurol. 1986 Dec; 94(3):767-76. PMID: 3780919.
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    456. Olverman HJ, Monaghan DT, Cotman CW, Watkins JC. [3H]CPP, a new competitive ligand for NMDA receptors. Eur J Pharmacol. 1986 Nov 12; 131(1):161-2. PMID: 3028828.
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    457. Monaghan DT, Cotman CW. Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7532-6. PMID: 3020547.
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    458. Harris EW, Cotman CW. Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl D-aspartate antagonists. Neurosci Lett. 1986 Sep 25; 70(1):132-7. PMID: 3022192.
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    459. Gibbs RB, Anderson K, Cotman CW. Factors affecting innervation in the CNS: comparison of three cholinergic cell types transplanted to the hippocampus of adult rats. Brain Res. 1986 Sep 24; 383(1-2):362-6. PMID: 3768701.
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    460. Gibbs RB, Pixley SK, Cotman CW. Transplantation of septal neurons maintained in long-term culture. Brain Res. 1986 Sep 24; 382(2):409-15. PMID: 3756524.
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    461. Stevens DR, Cotman CW. Excitatory amino acid antagonists depress transmission in hippocampal projections to the lateral septum. Brain Res. 1986 Sep 24; 382(2):437-40. PMID: 2875769.
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    462. Harris EW, Ganong AH, Monaghan DT, Watkins JC, Cotman CW. Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus. Brain Res. 1986 Sep 10; 382(1):174-7. PMID: 2876750.
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    463. Cotman CW, Flatman JA, Ganong AH, Perkins MN. Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea-pig hippocampus. J Physiol. 1986 Sep; 378:403-15. PMID: 3795109.
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    464. Geddes JW, Cotman CW. Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease. Neurosci Res. 1986 Sep; 3(6):672-8. PMID: 2877425.
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    465. Hearn TJ, Ganong AH, Cotman CW. Antagonism of lateral olfactory tract synaptic potentials in rat prepyriform cortex slices. Brain Res. 1986 Aug 06; 379(2):372-6. PMID: 3155349.
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    466. Anderson KJ, Gibbs RB, Salvaterra PM, Cotman CW. Ultrastructural characterization of identified cholinergic neurons transplanted to the hippocampal formation of the rat. J Comp Neurol. 1986 Jul 08; 249(2):279-92. PMID: 3525619.
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    467. Monaghan DT, Nguyen L, Cotman CW. The distribution of [3H]kainate binding sites in primate hippocampus is similar to the distribution of both Ca2+-sensitive and Ca2+-insensitive [3H]kainate binding sites in rat hippocampus. Neurochem Res. 1986 Jul; 11(7):1073-82. PMID: 3748275.
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    468. Needels DL, Nieto-Sampedro M, Cotman CW. Induction of a neurite-promoting factor in rat brain following injury or deafferentation. Neuroscience. 1986 Jul; 18(3):517-26. PMID: 3748376.
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    469. Bridges RJ, Hearn TJ, Monaghan DT, Cotman CW. A comparison of 2-amino-4-phosphonobutyric acid (AP4) receptors and [3H]AP4 binding sites in the rat brain. Brain Res. 1986 Jun 04; 375(1):204-9. PMID: 3013370.
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    470. Millaruelo AI, Nieto-Sampedro M, Yu J, Cotman CW. Neurotrophic activity in the central and peripheral nervous systems of the cat. Effects of injury. Brain Res. 1986 May 21; 374(1):12-20. PMID: 3719321.
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    471. Kesslak JP, Nieto-Sampedro M, Globus J, Cotman CW. Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation. Exp Neurol. 1986 May; 92(2):377-90. PMID: 3956668.
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    472. Ganong AH, Jones AW, Watkins JC, Cotman CW. Parallel antagonism of synaptic transmission and kainate/quisqualate responses in the hippocampus by piperazine-2,3-dicarboxylic acid analogs. J Neurosci. 1986 Apr; 6(4):930-7. PMID: 3009733.
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    473. Anderson KJ, Holets VR, Mazur PC, Lasher RS, Cotman CW. Immunocytochemical localization of serotonin in the rat dentate gyrus following raphe transplants. Brain Res. 1986 Mar 26; 369(1-2):21-8. PMID: 3516310.
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    474. Thompson R, Gibbs RB, Ristic GA, Cotman CW, Yu J. Lack of correlation between cortical levels of choline acetyltransferase and learning scores in rats with globus pallidus lesions. Brain Res. 1986 Mar 05; 367(1-2):402-4. PMID: 3697716.
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    475. Pixley SK, Cotman CW. Laminin supports short-term survival of rat septal neurons in low-density, serum-free cultures. J Neurosci Res. 1986; 15(1):1-17. PMID: 2421001.
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    476. Thompson R, Gibbs RB, Ristic GA, Cotman CW, Yu J. Learning deficits in rats with early neurotoxic lesions to the globus pallidus, substantia nigra, median raphe or pontine reticular formation. Physiol Behav. 1986; 37(1):141-51. PMID: 3737712.
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    477. Cotman CW, Monaghan DT. Anatomical organization of excitatory amino acid receptors and their properties. Adv Exp Med Biol. 1986; 203:237-52. PMID: 3024456.
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    478. Ganong AH, Cotman CW. Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus. J Pharmacol Exp Ther. 1986 Jan; 236(1):293-9. PMID: 2867215.
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    479. Geddes JW, Monaghan DT, Cotman CW, Lott IT, Kim RC, Chui HC. Plasticity of hippocampal circuitry in Alzheimer's disease. Science. 1985 Dec 06; 230(4730):1179-81. PMID: 4071042.
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    480. Monaghan DT, Cotman CW. Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain. J Neurosci. 1985 Nov; 5(11):2909-19. PMID: 2865341.
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    481. Nieto-Sampedro M, Needels DL, Cotman CW. A simple, objective method to measure the activity of factors that promote neuronal survival. J Neurosci Methods. 1985 Oct; 15(1):37-48. PMID: 4058061.
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    482. Nieto-Sampedro M, Saneto RP, de Vellis J, Cotman CW. The control of glial populations in brain: changes in astrocyte mitogenic and morphogenic factors in response to injury. Brain Res. 1985 Sep 23; 343(2):320-8. PMID: 3876863.
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    483. Monaghan DT, Yao D, Cotman CW. L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis. Brain Res. 1985 Aug 12; 340(2):378-83. PMID: 2862960.
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    484. Mena EE, Cotman CW. Pathologic concentrations of ammonium ions block L-glutamate uptake. Exp Neurol. 1985 Jul; 89(1):259-63. PMID: 4007108.
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    485. Gibbs RB, Harris EW, Cotman CW. Replacement of damaged cortical projections by homotypic transplants of entorhinal cortex. J Comp Neurol. 1985 Jul 01; 237(1):47-64. PMID: 2995456.
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    486. Whittemore SR, Nieto-Sampedro M, Needels DL, Cotman CW. Neuronotrophic factors for mammalian brain neurons: injury induction in neonatal, adult and aged rat brain. Brain Res. 1985 Jun; 352(2):169-78. PMID: 4027662.
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    487. Harris EW, Cotman CW. Effects of synaptic antagonists on perforant path paired-pulse plasticity: differentiation of pre- and postsynaptic antagonism. Brain Res. 1985 May 20; 334(2):348-53. PMID: 2986785.
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    488. Altschuler RA, Monaghan DT, Haser WG, Wenthold RJ, Curthoys NP, Cotman CW. Immunocytochemical localization of glutaminase-like and aspartate aminotransferase-like immunoreactivities in the rat and guinea pig hippocampus. Brain Res. 1985 Mar 25; 330(2):225-33. PMID: 3886076.
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    489. Mena EE, Monaghan DT, Whittemore SR, Cotman CW. Cations differentially affect subpopulations of L-glutamate receptors in rat synaptic plasma membranes. Brain Res. 1985 Mar 11; 329(1-2):319-22. PMID: 2983842.
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    490. Needels DL, Nieto-Sampedro M, Whittemore SR, Cotman CW. Neuronotrophic activity for ciliary ganglion neurons. Induction following injury to the brain of neonatal, adult, and aged rats. Brain Res. 1985 Feb; 350(1-2):275-84. PMID: 3986618.
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    491. Cotman CW, Nieto-Sampedro M. Progress in facilitating the recovery of function after central nervous system trauma. Ann N Y Acad Sci. 1985; 457:83-104. PMID: 3913366.
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    492. Monaghan DT, Yao D, Olverman HJ, Watkins JC, Cotman CW. Autoradiography of D-2-[3H]amino-5-phosphonopentanoate binding sites in rat brain. Neurosci Lett. 1984 Dec 21; 52(3):253-8. PMID: 6151632.
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    493. Monaghan DT, Yao D, Cotman CW. Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography. Brain Res. 1984 Dec 17; 324(1):160-4. PMID: 6097340.
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    494. Mena EE, Whittemore SR, Monaghan DT, Cotman CW. Ionic regulation of glutamate binding sites. Life Sci. 1984 Dec 10; 35(24):2427-33. PMID: 6151108.
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    495. Harris EW, Ganong AH, Cotman CW. Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Res. 1984 Dec 03; 323(1):132-7. PMID: 6151863.
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    496. Nieto-Sampedro M, Whittemore SR, Needels DL, Larson J, Cotman CW. The survival of brain transplants is enhanced by extracts from injured brain. Proc Natl Acad Sci U S A. 1984 Oct; 81(19):6250-4. PMID: 6592613.
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    497. Cotman CW, Nieto-Sampedro M. Cell biology of synaptic plasticity. Science. 1984 Sep 21; 225(4668):1287-94. PMID: 6382610.
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    498. Holets VR, Cotman CW. Postnatal development of the serotonin innervation of the hippocampus and dentate gyrus following raphe implants. J Comp Neurol. 1984 Jul 10; 226(4):457-76. PMID: 6378990.
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    499. Cotman CW. In memoriam: Henry R. Mahler 1921-1983. J Neurochem. 1984 Apr; 42(4):1200-2. PMID: 6366121.
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    500. Lanthorn TH, Ganong AH, Cotman CW. 2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus. Brain Res. 1984 Jan 02; 290(1):174-8. PMID: 6318908.
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    501. Harris EW, Cotman CW. Brain tissue transplantation research. Appl Neurophysiol. 1984; 47(1-2):9-15. PMID: 6508282.
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    502. Cotman CW, Nieto-Sampedro M, Gibbs RB. Enhancing the self-repairing potential of the CNS after injury. Cent Nerv Syst Trauma. 1984; 1(1):3-14. PMID: 6400198.
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    503. DeKosky ST, Scheff SW, Cotman CW. Elevated corticosterone levels. A possible cause of reduced axon sprouting in aged animals. Neuroendocrinology. 1984 Jan; 38(1):33-8. PMID: 6537997.
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    504. Williams LR, Manthorpe M, Barbin G, Nieto-Sampedro M, Cotman CW, Varon S. High ciliary neuronotrophic specific activity in rat peripheral nerve. Int J Dev Neurosci. 1984; 2(2):177-80. PMID: 24873961.
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    505. Lanthorn TH, Cotman CW. Relative potency of analogues of excitatory amino acids on hippocampal CA1 neurons. Neuropharmacology. 1983 Dec; 22(12A):1343-8. PMID: 6664465.
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    506. Monaghan DT, McMills MC, Chamberlin AR, Cotman CW. Synthesis of [3H]2-amino-4-phosphonobutyric acid and characterization of its binding to rat brain membranes: a selective ligand for the chloride/calcium-dependent class of L-glutamate binding sites. Brain Res. 1983 Nov 14; 278(1-2):137-44. PMID: 6640305.
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    507. Nieto-Sampedro M, Manthrope M, Barbin G, Varon S, Cotman CW. Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity. J Neurosci. 1983 Nov; 3(11):2219-29. PMID: 6631476.
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    508. Monaghan DT, Holets VR, Toy DW, Cotman CW. Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites. Nature. 1983 Nov 10-16; 306(5939):176-9. PMID: 6316143.
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    509. Whittemore SR, Mena EE, Monaghan DT, Cotman CW. Regional distribution and ionic requirement of Cl-/Ca2+-activated and Cl-/Ca2+-independent glutamate receptors in rat brain. Brain Res. 1983 Oct 24; 277(1):99-107. PMID: 6315142.
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    510. Ganong AH, Lanthorn TH, Cotman CW. Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord. Brain Res. 1983 Aug 22; 273(1):170-4. PMID: 6311346.
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    511. Fagg GE, Mena EE, Monaghan DT, Cotman CW. Freezing eliminates a specific population of L-glutamate receptors in synaptic membranes. Neurosci Lett. 1983 Jul 29; 38(2):157-62. PMID: 6312382.
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    512. Manthorpe M, Nieto-Sampedro M, Skaper SD, Lewis ER, Barbin G, Longo FM, Cotman CW, Varon S. Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity. Brain Res. 1983 May 09; 267(1):47-56. PMID: 6860949.
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    513. Fagg GE, Foster AC, Mena EE, Cotman CW. Chloride and calcium ions separate L-glutamate receptor populations in synaptic membranes. Eur J Pharmacol. 1983 Mar 18; 88(1):105-10. PMID: 6133761.
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    514. Koerner JF, Cotman CW. A microperfusion chamber for brain slice pharmacology. J Neurosci Methods. 1983 Mar; 7(3):243-51. PMID: 6302404.
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    515. Wendt JS, Fagg GE, Cotman CW. Regeneration of rat hippocampal fimbria fibers after fimbria transection and peripheral nerve or fetal hippocampal implantation. Exp Neurol. 1983 Feb; 79(2):452-61. PMID: 6822275.
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    516. Lewis ER, Cotman CW. Neurotransmitter characteristics of brain grafts: striatal and septal tissues form the same laminated input to the hippocampus. Neuroscience. 1983 Jan; 8(1):57-66. PMID: 6132349.
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    517. Cotman CW, Hoff SF. Synapse repair in the hippocampus: the effects of aging. Birth Defects Orig Artic Ser. 1983; 19(4):119-34. PMID: 6871392.
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    518. Fagg GE, Mena EE, Cotman CW. L-glutamate receptor populations in synaptic membranes: effects of ions and pharmacological characteristics. Adv Biochem Psychopharmacol. 1983; 37:199-209. PMID: 6314758.
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    519. Harris EW, Cotman CW. Effects of acidic amino acid antagonists on paired-pulse potentiation at the lateral perforant path. Exp Brain Res. 1983; 52(3):455-60. PMID: 6317423.
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    520. Vijayan VK, Cotman CW. Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats. Neurobiol Aging. 1983; 4(1):13-23. PMID: 6877483.
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    521. Ganong AH, Cotman CW. Acidic amino acid antagonists of lateral perforant path synaptic transmission: agonist-antagonist interactions in the dentate gyrus. Neurosci Lett. 1982 Dec 30; 34(2):195-200. PMID: 6135181.
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    522. Monaghan DT, Cotman CW. The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res. 1982 Dec 02; 252(1):91-100. PMID: 6293660.
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    523. Sampedro MN, Bussineau CM, Cotman CW. Turnover of brain postsynaptic densities after selective deafferentation: detection by means of an antibody to antigen PSD-95. Brain Res. 1982 Nov 18; 251(2):211-20. PMID: 7139323.
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    524. Koerner JF, Cotman CW. Response of Schaffer collateral-CA 1 pyramidal cell synapses of the hippocampus to analogues of acidic amino acids. Brain Res. 1982 Nov 11; 251(1):105-15. PMID: 7171996.
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    525. Nieto-Sampedro M, Hoff SF, Cotman CW. Perforated postsynaptic densities: probable intermediates in synapse turnover. Proc Natl Acad Sci U S A. 1982 Sep; 79(18):5718-22. PMID: 6957887.
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    526. Nieto-Sampedro M, Lewis ER, Cotman CW, Manthorpe M, Skaper SD, Barbin G, Longo FM, Varon S. Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site. Science. 1982 Aug 27; 217(4562):860-1. PMID: 7100931.
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    527. Fagg GE, Foster AC, Harris EW, Lanthorn TH, Cotman CW. Structure--activity relationships of L-glutamate receptor ligands: role of the omega-acidic terminal. Neurosci Lett. 1982 Jul 20; 31(1):59-64. PMID: 6126848.
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    528. Mena EE, Fagg GE, Cotman CW. Chloride ions enhance L-glutamate binding to rat brain synaptic membranes. Brain Res. 1982 Jul 15; 243(2):378-81. PMID: 6125247.
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    529. Fagg GE, Foster AC, Mena EE, Cotman CW. Chloride and calcium ions reveal a pharmacologically distinct population of L-glutamate binding sites in synaptic membranes: correspondence between biochemical and electrophysiological data. J Neurosci. 1982 Jul; 2(7):958-65. PMID: 6124584.
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    530. Foster AC, Fagg GE, Harris EW, Cotman CW. Regulation of glutamate receptors: possible role of phosphatidylserine. Brain Res. 1982 Jun 24; 242(2):374-7. PMID: 6288170.
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    531. Scheff SW, Cotman CW. Chronic glucocorticoid therapy alters axon sprouting in the hippocampal dentate gyrus. Exp Neurol. 1982 Jun; 76(3):644-54. PMID: 7084379.
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    532. Nieto-Sampedro M, Bussineau CM, Cotman CW. Isolation, morphology, and protein and glycoprotein composition of synaptic junctional fractions from the brain of lower vertebrates: antigen PSD-95 as a junctional marker. J Neurosci. 1982 Jun; 2(6):722-34. PMID: 7086480.
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    533. Mena EE, Cotman CW. Synaptic cleft glycoproteins contain homologous amino acid sequences. Science. 1982 Apr 23; 216(4544):422-4. PMID: 7071591.
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    534. Hoff SF, Scheff SW, Cotman CW. Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response. J Comp Neurol. 1982 Mar 01; 205(3):253-9. PMID: 7076896.
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    535. Hoff SF, Scheff SW, Benardo LS, Cotman CW. Lesion-induced synaptogenesis in the dentate gyrus of aged rats: I. Loss and reacquisition of normal synaptic density. J Comp Neurol. 1982 Mar 01; 205(3):246-52. PMID: 7076895.
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    536. Monaghan DT, Mena EE, Cotman CW. The effect of entorhinal cortical ablation on the distribution of muscarinic cholinergic receptors in the rat hippocampus. Brain Res. 1982 Feb 25; 234(2):480-5. PMID: 7059841.
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    537. Lewis ER, Cotman CW. Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. III. Competitive interactions. Brain Res. 1982 Feb 04; 233(1):29-44. PMID: 7059804.
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    538. Lewis ER, Cotman CW. Mechanisms of septal lamination in the developing hippocampus analyzed by outgrowth of fibers from septal implants. II. Absence of guidance by degenerative debris. J Neurosci. 1982 Jan; 2(1):66-77. PMID: 7054397.
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    539. Beach RL, Bathgate SL, Cotman CW. Identification of cell types in rat hippocampal slices maintained in organotypic cultures. Brain Res. 1982 Jan; 255(1):3-20. PMID: 7034866.
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    540. Cotman CW, Nieto-Sampedro M. Brain function, synapse renewal, and plasticity. Annu Rev Psychol. 1982; 33:371-401. PMID: 6277238.
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    541. Foster AC, Fagg GE, Mena EE, Cotman CW. L-glutamate and L-aspartate bind to separate sites in rat brain synaptic membranes. Brain Res. 1981 Dec 14; 229(1):246-50. PMID: 6118199.
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    542. Fagg GE, Scheff SW, Cotman CW. Axonal sprouting at the neuromuscular junction of adult and aged rats. Exp Neurol. 1981 Dec; 74(3):847-54. PMID: 7308373.
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    543. Mena EE, Foster AC, Fagg GE, Cotman CW. Identification of synapse specific components: synaptic glycoproteins, proteins, and transmitter binding sites. J Neurochem. 1981 Dec; 37(6):1557-66. PMID: 6120997.
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    544. Lanthorn TH, Cotman CW. Baclofen selectively inhibits excitatory synaptic transmission in the hippocampus. Brain Res. 1981 Nov 23; 225(1):171-8. PMID: 6271336.
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    545. Beach RL, Kelly PT, Babitch JA, Cotman CW. Identification of myosin in isolated synaptic junctions. Brain Res. 1981 Nov 23; 225(1):75-93. PMID: 7296281.
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    546. Hoff SF, Scheff SW, Kwan AY, Cotman CW. A new type of lesion-induced synaptogenesis: II. The effect of aging on synaptic turnover in non-denervated zones. Brain Res. 1981 Oct 05; 222(1):15-27. PMID: 7296261.
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    547. Hoff SF, Scheff SW, Kwan AY, Cotman CW. A new type of lesion-induced synaptogenesis: I. Synaptic turnover in non-denervated zones of the dentate gyrus in young adult rats. Brain Res. 1981 Oct 05; 222(1):1-13. PMID: 7296257.
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    548. Sampedro MN, Bussineau CM, Cotman CW. Postsynaptic density antigens: preparation and characterization of an antiserum against postsynaptic densities. J Cell Biol. 1981 Sep; 90(3):675-86. PMID: 6169734.
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    549. Koerner JF, Cotman CW. Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex. Brain Res. 1981 Jul 06; 216(1):192-8. PMID: 6266585.
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    550. Cotman CW, Nieto-Sampedro M, Harris EW. Synapse replacement in the nervous system of adult vertebrates. Physiol Rev. 1981 Jul; 61(3):684-784. PMID: 7019944.
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    551. Foster AC, Mena EE, Fagg GE, Cotman CW. Glutamate and aspartate binding sites are enriched in synaptic junctions isolated from rat brain. J Neurosci. 1981 Jun; 1(6):620-5. PMID: 6286899.
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    552. Nadler JV, Perry BW, Gentry C, Cotman CW. Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. J Comp Neurol. 1981 Mar 10; 196(4):549-69. PMID: 7204671.
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    553. Nieto-Sampedro M, Bussineau CM, Cotman CW. Optimal concentration of iodonitrotetrazolium for the isolation of junctional fractions from rat brain. Neurochem Res. 1981 Mar; 6(3):307-20. PMID: 7279108.
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    554. Kelly PT, Cotman CW. Developmental changes in morphology and molecular composition of isolated synaptic junctional structures. Brain Res. 1981 Feb 16; 206(2):251-7. PMID: 7214135.
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    555. Foster AC, Mena EE, Monaghan DT, Cotman CW. Synaptic localization of kainic acid binding sites. Nature. 1981 Jan 01; 289(5793):73-5. PMID: 6256647.
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    556. Mena EE, Monaghan DT, Cotman CW. Lesion-induced alterations of lectin binding sites in the rat dentate gyrus. Neuroscience. 1981; 6(10):1975-83. PMID: 7301114.
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    557. Cotman CW, Foster A, Lanthorn T. An overview of glutamate as a neurotransmitter. Adv Biochem Psychopharmacol. 1981; 27:1-27. PMID: 6108689.
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    558. Scheff SW, Benardo LS, Cotman CW. Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal. Brain Res. 1980 Oct 13; 199(1):21-38. PMID: 7407623.
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    559. Lewis ER, Cotman CW. Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. I. Positional and temporal factors. Brain Res. 1980 Sep 08; 196(2):307-30. PMID: 7397534.
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    560. Nadler JV, Perry BW, Gentry C, Cotman CW. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J Comp Neurol. 1980 Jul 15; 192(2):333-59. PMID: 7400401.
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    561. Nadler JV, Perry BW, Gentry C, Cotman CW. Loss and reacquisition of hippocampal synapses after selective destruction of CA3-CA4 afferents with kainic acid. Brain Res. 1980 Jun 09; 191(2):387-403. PMID: 7378766.
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    562. Lewis ER, Cotman CW. Factors specifying the development of synapse number in the rat dentate gyrus: effects of partial target loss. Brain Res. 1980 Jun 02; 191(1):35-52. PMID: 7378759.
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    563. Nieto-Sampedro M, Shelton D, Cotman CW. Specific binding of kainic acid to purified subcellular fractions from rat brain. Neurochem Res. 1980 Jun; 5(6):591-604. PMID: 6250092.
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    564. Lewis ER, Mueller JC, Cotman CW. Neonatal septal implants: development of afferent lamination in the rat dentate gyrus. Brain Res Bull. 1980 May-Jun; 5(3):217-21. PMID: 7397565.
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    565. Nadler JV, Perry BW, Cotman CW. Interaction with CA4-derived fibers accounts for distribution of septohippocampal fibers in rat fascia dentata after entorhinal lesion. Exp Neurol. 1980 Apr; 68(1):185-94. PMID: 7363985.
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    566. Scheff SW, Benardo LS, Cotman CW. Hydrocortison administration retards axon sprouting in the rat dentate gyrus. Exp Neurol. 1980 Apr; 68(1):195-201. PMID: 7363986.
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    567. Nadler JV, Perry BW, Cotman CW. Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid. Brain Res. 1980 Jan 20; 182(1):1-9. PMID: 7350980.
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    568. Nadler JV, Shelton DL, Perry BW, Cotman CW. Regional distribution of [3H]kainic acid after intraventricular injection. Life Sci. 1980 Jan 14; 26(2):133-8. PMID: 7366321.
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    569. Goldowitz D, Cotman CW. Do neurotrophic interactions control synapse formation in the adult rat brain? Brain Res. 1980 Jan 13; 181(2):325-44. PMID: 6153147.
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    570. Goldowitz D, Cotman CW. Axonal transport and axon sprouting in the adult rat dentate gyrus: an autoradiographic study. Neuroscience. 1980; 5(12):2163-74. PMID: 6162129.
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    571. White WF, Nadler JV, Cotman CW. Analysis of short-term plasticity at the perforant path-granule cell synapse. Brain Res. 1979 Dec 07; 178(1):41-53. PMID: 497863.
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    572. Goldowitz D, Scheff SW, Cotman CW. The specificity of reactive synaptogenesis: a comparative study in the adult rat hippocampal formation. Brain Res. 1979 Jul 20; 170(3):427-41. PMID: 466422.
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    573. Hamberger AC, Chiang GH, Nylén ES, Scheff SW, Cotman CW. Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res. 1979 Jun 08; 168(3):513-30. PMID: 435980.
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    574. Hamberger A, Chiang GH, Sandoval E, Cotman CW. Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool. Brain Res. 1979 Jun 08; 168(3):531-41. PMID: 435981.
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    575. Rostas JA, Kelly PT, Pesin RH, Cotman CW. Protein and glycoprotein composition of synaptic junctions prepared from discrete synaptic regions and different species. Brain Res. 1979 May 18; 168(1):151-67. PMID: 455075.
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    576. Nadler JV, Shelton DL, Cotman CW. Lesion-induced plasticity of high affinity choline uptake in the developing rat fascia dentata. Brain Res. 1979 Mar 23; 164:207-16. PMID: 427557.
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    577. White WF, Nadler JV, Cotman CW. The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro. Brain Res. 1979 Mar 23; 164:177-94. PMID: 218685.
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    578. Shelton DL, Nadler JV, Cotman CW. Development of high affinity choline uptake and associated acetylcholine synthesis in the rat fascia dentata. Brain Res. 1979 Mar 16; 163(2):263-75. PMID: 427545.
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    579. Kelly PT, Cotman CW, Largen M. Cyclic AMP-stimulated protein kinases at brain synaptic junctions. J Biol Chem. 1979 Mar 10; 254(5):1564-75. PMID: 216697.
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    580. Cotman CW, Scheff SW. Compensatory synapse growth in aged animals after neuronal death. Mech Ageing Dev. 1979 Jan; 9(1-2):103-17. PMID: 439948.
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    581. Haycock JW, Levy WB, Denner LA, Cotman CW. Stimulus-secretion coupling processes in brain: dependence upon extracellular calcium concentration. Neuroscience. 1979; 4(9):1341-6. PMID: 492540.
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    582. Cotman CW. Specificity of synaptic growth in brain: remodeling induced by kainic acid lesions. Prog Brain Res. 1979; 51:203-15. PMID: 551480.
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    583. Scheff SW, Benardo LS, Cotman CW. Lesion-induced vascular changes in the dentate gyrus following removal of the entorhinal cortex in adult rats. Exp Neurol. 1978 Dec; 62(3):815-20. PMID: 750225.
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    584. Scheff SW, Bernardo LS, Cotman CW. Decrease in adrenergic axon sprouting in the senescent rat. Science. 1978 Nov 17; 202(4369):775-8. PMID: 715443.
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    585. Hamberger A, Cummins JT, Keller E, Cotman CW. Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus. Brain Res. 1978 Nov 10; 156(2):253-64. PMID: 30519.
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    586. Haycock JW, Levy WB, Cotman CW. Stimulation-dependent depression of neurotransmitter release in brain: [Ca2+]o dependence. Brain Res. 1978 Oct 20; 155(1):192-5. PMID: 28816.
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    587. Kelly PT, Cotman CW. Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide. J Cell Biol. 1978 Oct; 79(1):173-83. PMID: 568145.
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    588. White WF, Nadler JV, Cotman CW. A perfusion chamber for the study of CNS physiology and pharmacology in vitro. Brain Res. 1978 Sep 08; 152(3):591-6. PMID: 687977.
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    589. Goldwitz D, Cotman CW. Induction of extensive fimbrial branching in the adult rat brain. Nature. 1978 Sep 07; 275(5675):64-7. PMID: 683343.
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    590. Scheff SW, Benardo LS, Cotman CW. Effect of serial lesions on sprouting in the dentate gyrus: onset and decline of the catalytic effect. Brain Res. 1978 Jul 07; 150(1):45-53. PMID: 667622.
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    591. Nadler JV, White WF, Vaca KW, Perry BW, Cotman CW. Biochemical correlates of transmission mediated by glutamate and aspartate. J Neurochem. 1978 Jul; 31(1):147-55. PMID: 209140.
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    592. Haycock JW, Levy WB, Denner LA, Cotman CW. Effects of elevated [K+]O on the release of neurotransmitters from cortical synaptosomes: efflux or secretion? J Neurochem. 1978 May; 30(5):1113-25. PMID: 660189.
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    593. Hamberger A, Chiang G, Nylén ES, Scheff SW, Cotman CW. Stimulus evoked increase in the biosynthesis of the putative neurotransmitter glutamate in the hippocampus. Brain Res. 1978 Mar 31; 143(3):549-55. PMID: 25693.
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    594. Sandoval ME, Horch P, Cotman CW. Evaluation of glutamate as a hippocampal neurotransmitter: glutamate uptake and release from synaptosomes. Brain Res. 1978 Feb 24; 142(2):285-99. PMID: 343884.
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    595. Nadler JV, Cotman CW. Interactions between afferents to the dentate gyrus after entorhinal lesion during development: long-term regulation of choline acetyl-transferase activity. Brain Res. 1978 Feb 17; 142(1):174-81. PMID: 626916.
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    596. Nadler JV, Perry BW, Cotman CW. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells. Nature. 1978 Feb 16; 271(5646):676-7. PMID: 625338.
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    597. Sandoval ME, Cotman CW. Evaluation of glutamate as a neurotransmitter of cerebellar parallel fibers. Neuroscience. 1978; 3(2):199-206. PMID: 32498.
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    598. Haycock JW, White WF, Cotman CW. Differences in alkaline earth stimulation of neurotransmitter release from isolated brain synaptosomes. Naunyn Schmiedebergs Arch Pharmacol. 1978 Jan-Feb; 301(3):175-9. PMID: 24809.
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    599. Haycock JW, White WF, McGaugh JL, Cotman CW. Enhanced stimulus--secretion coupling from brains of aged mice. Exp Neurol. 1977 Dec; 57(3):873-82. PMID: 923678.
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    600. White WF, Nadler JV, Hamberger A, Cotman CW, Cummins JT. Glutamate as transmitter of hippocampal perforant path. Nature. 1977 Nov 24; 270(5635):356-7. PMID: 22816.
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    601. Steward O, White WF, Cotman CW. Potentiation of the excitatory synaptic action of commissural, associational and entorhinal afferents to dentate granule cells. Brain Res. 1977 Oct 14; 134(3):551-60. PMID: 198066.
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    602. Scheff SW, Cotman CW. Recovery of spontaneous alternation following lesions of the entorhinal cortex in adult rats: possible correlation to axon sprouting. Behav Biol. 1977 Oct; 21(2):286-93. PMID: 911288.
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    603. Lee KS, Stanford EJ, Cotman CW, Lynch GS. Ultrastructural evidence for bouton proliferation in the partially deafferented dentate gyrus of the adult rat. Exp Brain Res. 1977 Sep 28; 29(3-4):475-85. PMID: 913527.
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    604. Yen SH, Liem RK, Kelly PT, Cotman CW, Shelanski ML. Membrane linked proteins at CNS synapses. Brain Res. 1977 Aug 19; 132(1):172-5. PMID: 329950.
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    605. Nadler JV, White WF, Vaca KW, Cotman CW. Calcium-dependent gamma-aminobutyrate release by interneurons of rat hippocampal regions: lesion-induced plasticity. Brain Res. 1977 Aug 12; 131(2):241-58. PMID: 890456.
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    606. Nadler JV, White WF, Vaca KW, Redburn DA, Cotman CW. Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. J Neurochem. 1977 Aug; 29(2):279-90. PMID: 18560.
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    607. Rostas JA, Kelly PT, Cotman CW. The identification of membrane glycocomponents in polyacrylamide gels: a rapid method using 125I-labeled lectins. Anal Biochem. 1977 Jun; 80(2):366-72. PMID: 889076.
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    608. Feit H, Kelly P, Cotman CW. Identification of a protein related to tubulin in the postsynaptic density. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):1047-51. PMID: 265548.
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    609. Nadler JV, Cotman CW, Lynch GS. Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. I. Time course after complete unilateral entorhinal lesion at various ages. J Comp Neurol. 1977 Feb 15; 171(4):561-87. PMID: 833358.
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    610. Nadler JV, Cotman CW, Paoletti C, Lynch GS. Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions. J Comp Neurol. 1977 Feb 15; 171(4):589-604. PMID: 833359.
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    611. Loy R, Lynch G, Cotman CW. Development of afferent lamination in the fascia dentata of the rat. Brain Res. 1977 Feb; 121(2):229-43. PMID: 832161.
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    612. Kelly PT, Cotman CW. Identification of glycoproteins and proteins at synapses in the central nervous system. J Biol Chem. 1977 Jan 25; 252(2):786-93. PMID: 833152.
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    613. Kelly PT, Cotman CW. Intermolecular disulfide bonds at central nervous system synaptic junctions. Biochem Biophys Res Commun. 1976 Dec 20; 73(4):858-64. PMID: 15625853.
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    614. Cotman CW, Haycock JW, Levy WB. On the functional coupling of neurotransmitter uptake and release in brain. Br J Pharmacol. 1976 Dec; 58(4):569-72. PMID: 11862.
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    615. Steward O, White CW, Cotman CW, Lynch G. Potentiation of excitatory synaptic transmission in the normal and in the reinnervated dentate gyrus of the rat. Exp Brain Res. 1976 Nov 23; 26(4):423-41. PMID: 187442.
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    616. Kelly P, Cotman CW, Gentry C, Nicolson GL. Distribution and mobility of lectin receptors on synaptic membranes of identified neurons in the central nervous system. J Cell Biol. 1976 Nov; 71(2):487-96. PMID: 993260.
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    617. West JR, Deadwyler SA, Cotman CW, Lynch GS. An experimental test of diaschisis. Behav Biol. 1976 Nov; 18(3):419-25. PMID: 1016179.
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    618. Levy WB, Haycock JW, Cotman CW. Stimulation-dependent depression of readily releasable neurotransmitter pools in brain. Brain Res. 1976 Oct 15; 115(2):243-56. PMID: 788858.
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    619. White WF, Goldowitz D, Lynch G, Cotman CW. Electrophysiological analysis of the projection from the contralateral entorhinal cortex to the dentate gyrus in normal rats. Brain Res. 1976 Sep 17; 114(2):201-9. PMID: 963548.
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    620. Spencer HJ, Gribkoff VK, Cotman CW, Lynch GS. GDEE antagonism of iontophoretic amino acid excitations in the intact hippocampus and in the hippocampal slice preparation. Brain Res. 1976 Apr 09; 105(3):471-81. PMID: 1260458.
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    621. Nadler JV, Vaca KW, White WF, Lynch GS, Cotman CW. Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents. Nature. 1976 Apr 08; 260(5551):538-40. PMID: 4735.
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    622. Dudek FE, Deadwyler SA, Cotman CW, Lynch G. Intracellular responses from granule cell layer in slices of rat hippocampus: perforant path synapse. J Neurophysiol. 1976 Mar; 39(2):384-93. PMID: 1255228.
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    623. Redburn DA, Shelton D, Cotman CW. Calcium-dependent release of exogenously loaded gamma-amino-[U-14C]butyrate from synaptosomes: time course of stimulation by potassium, veratridine, and the calcium ionophore, A23187. J Neurochem. 1976 Feb; 26(2):297-303. PMID: 815512.
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    624. Cotman CW, Haycock JW, White WF. Stimulus-secretion coupling processes in brain: analysis of noradrenaline and gamma-aminobutyric acid release. J Physiol. 1976 Jan; 254(2):475-505. PMID: 765446.
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    625. Rose G, Lynch G, Cotman CW. Hypertrophy and redistribution of astrocytes in the deafferented dentate gyrus. Brain Res Bull. 1976 Jan-Feb; 1(1):87-92. PMID: 974798.
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    626. Cotman CW. Lesion-induced synaptogenesis in brain: a study of dynamic changes in neuronal membrane specializations. J Supramol Struct. 1976; 4(3):319-27. PMID: 4658.
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    627. West JR, Deadwyler S, Cotman CW, Lynch G. Time-dependent changes in commissural field potentials in the dentate gyrus following lesions of the entorhinal cortex in adult rats. Brain Res. 1975 Oct 31; 97(2):215-33. PMID: 1175043.
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    628. West JR, Deadwyler SA, Cotman CW, Lynch G. A dual marking technique for microelectrode tracks and localization recording sites. Electroencephalogr Clin Neurophysiol. 1975 Oct; 39(4):407-10. PMID: 51724.
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    629. Deadwyler SA, West JR, Cotman CW, Lynch G. Physiological studies of the reciprocal connections between the hippocampus and entorhinal cortex. Exp Neurol. 1975 Oct; 49(1 Pt 1):35-57. PMID: 171171.
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    630. Redburn DA, Biela J, Shelton DL, Cotman CW. Stimulus secretion coupling in vitro: a rapid perfusion apparatus for monitoring efflux of transmitter substances from tissue samples. Anal Biochem. 1975 Jul; 67(1):268-78. PMID: 238422.
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    631. Deadwyler SA, Dudek FE, Cotman CW, Lynch G. Intracellular responses of rat dentate granule cells in vitro: posttetanic potentiation to perforant path stimulation. Brain Res. 1975 Apr 25; 88(1):80-5. PMID: 1122406.
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    632. Drucker-Colín RR, Spanis CW, Cotman CW, McGaugh JL. Changes in protein levels in perfusates of freely moving cats: relation to behavioral state. Science. 1975 Mar 14; 187(4180):963-5. PMID: 167436.
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    633. Deadwyler SA, West JR, Cotman CW, Lynch GS. A neurophysiological analysis of commissural projections to dentate gyrus of the rat. J Neurophysiol. 1975 Jan; 38(1):167-84. PMID: 162942.
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    634. Russell RW, Overstreet DH, Cotman CW, Carson VG, Churchill L, Dalglish FW, Vasquez BJ. Experimental tests of hypotheses about neurochemical mechanisms underlying behavioral tolerance to the anticholinesterase, diisopropyl fluorophosphate. J Pharmacol Exp Ther. 1975 Jan; 192(1):73-85. PMID: 164530.
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    635. Chippendale TJ, Cotman CW, Kozar MD, Lynch GS. Analysis of acetylcholinesterase synthesis and transport in the rat hippocampus: recovery of acetylcholinesterase activity in the septum and hippocampus after administration of diisopropylfluorophosphate. Brain Res. 1974 Dec 13; 81(3):485-96. PMID: 4140010.
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    636. Cotman CW, Banker G, Churchill L, Taylor D. Isolation of postsynaptic densities from rat brain. J Cell Biol. 1974 Nov; 63(2 Pt 1):441-55. PMID: 4138148.
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    637. Nadler JV, Cotman CW, Lynch GS. Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion. Exp Neurol. 1974 Nov; 45(2):403-13. PMID: 4153783.
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    638. Banker G, Churchill L, Cotman CW. Proteins of the postsynaptic density. J Cell Biol. 1974 Nov; 63(2 Pt 1):456-65. PMID: 4419608.
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    639. Nadler JV, Cotman CW, Lynch GS. Subcellular distribution of transmitter-related enzyme activities in discrete areas of the rat dentate gyrus. Brain Res. 1974 Oct 25; 79(3):465-75. PMID: 4370916.
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    640. Cotman CW, Taylor D. Localization and characterization of concanavalin A receptors in the synaptic cleft. J Cell Biol. 1974 Jul; 62(1):236-42. PMID: 4407356.
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    641. Redburn DA, Cotman CW. Calcium-dependent release of (14C)GABA from vinblastine and colchicine treated synaptosomes. Brain Res. 1974 Jun 28; 73(3):550-7. PMID: 4835375.
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    642. Levy WB, Haycock JW, Cotman CW. Effects of polyvalent cations on stimulus-coupled secretion of (14C)-gamma-aminobutyric acid from isolated brain synaptosomes. Mol Pharmacol. 1974 May; 10(3):438-49. PMID: 4851770.
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    643. Steward O, Cotman CW, Lynch GS. Growth of a new fiber projection in the brain of adult rats: Re-innervation of the dentate gyrus by the contralateral entorhinal cortex following ipsilateral entorhinal lesions. Exp Brain Res. 1974 Apr 30; 20(1):45-66. PMID: 4367724.
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    644. Lynch G, Stanfield B, Parks T, Cotman CW. Evidence for selective post-lesion axonal growth in the dentate gyrus of the rat. Brain Res. 1974 Mar 29; 69(1):1-11. PMID: 4817913.
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    645. Parnavelas JG, Lynch G, Brecha N, Cotman CW, Globus A. Spine loss and regrowth in hippocampus following deafferentation. Nature. 1974 Mar 01; 248(5443):71-3. PMID: 4818565.
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    646. Lynch G, Gall C, Mensah P, Cotman CW. Horseradish peroxidase histochemistry: a new method for tracing efferent projections in the central nervous system. Brain Res. 1974 Jan 18; 65(3):373-80. PMID: 4137706.
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    647. Cotman CW. Isolation of synaptosomal and synaptic plasma membrane fractions. Methods Enzymol. 1974; 31:445-52. PMID: 4278474.
      View in: PubMed
    648. Matthews DA, Nadler JV, Lynch GS, Cotman CW. Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity. Dev Biol. 1974 Jan; 36(1):130-41. PMID: 4822829.
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    649. Nadler JV, Matthews DA, Cotman CW, Lynch GS. Development of cholinergic innervation in the hippocampal formation of the rat. II. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities. Dev Biol. 1974 Jan; 36(1):142-54. PMID: 4822830.
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    650. Nadler JV, Cotman CW, Lynch GS. Altered distribution of choline acetyltransferase and acetylcholinesterase activities in the developing rat dentate gyrus following entorhinal lesion. Brain Res. 1973 Dec 07; 63:215-20. PMID: 4357969.
      View in: PubMed
    651. Cotman CW, Matthews DA, Taylor D, Lynch G. Synaptic rearrangement in the dentate gyrus: histochemical evidence of adjustments after lesions in immature and adult rats. Proc Natl Acad Sci U S A. 1973 Dec; 70(12):3473-7. PMID: 4519639.
      View in: PubMed
    652. Steward O, Cotman CW, Lynch GS. Re-establishment of electrophysiologically functional entorhinal cortical input to the dentate gyrus deafferented by ipsilateral entorhinal lesions: innervation by the contralateral entorhinal cortex. Exp Brain Res. 1973 Nov 29; 18(4):396-414. PMID: 4778785.
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    653. Mosko S, Lynch G, Cotman CW. The distribution of septal projections to the hippocampus of the rat. J Comp Neurol. 1973 Nov 15; 152(2):163-74. PMID: 4761657.
      View in: PubMed
    654. Lynch G, Stanfield B, Cotman CW. Developmental differences in post-lesion axonal growth in the hippocampus. Brain Res. 1973 Sep 14; 59:155-68. PMID: 4747748.
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    655. Levy WB, Redburn DA, Cotman CW. Stimulus-coupled secretion of gamma-aminobutyric acid from rat brain synaptosomes. Science. 1973 Aug 17; 181(4100):676-8. PMID: 4724481.
      View in: PubMed
    656. Lynch GS, Mosko S, Parks T, Cotman CW. Relocation and hyperdevelopment of the dentate gyrus commissural system after entorhinal lesions in immature rats. Brain Res. 1973 Feb 14; 50(1):174-8. PMID: 4690544.
      View in: PubMed
    657. Churchill L, Cotman CW. Analytical zonal centrifugation of synaptosomes and mitochondria from rat brain homogenates. Neurobiology. 1973; 3(5):311-9. PMID: 4361765.
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    658. Cotman CW, Taylor D. Isolation and structural studies on synaptic complexes from rat brain. J Cell Biol. 1972 Dec; 55(3):696-711. PMID: 4656707.
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    659. Banker G, Crain B, Cotman CW. Molecular weights of the polypeptide chains of synaptic plasma membranes. Brain Res. 1972 Jul 20; 42(2):508-13. PMID: 5050181.
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    660. Cotman CW, Matthews DA. Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization. Biochim Biophys Acta. 1971 Dec 03; 249(2):380-94. PMID: 4257325.
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    661. Cotman CW, McCaman RE, Dewhurst SA. Subsynaptosomal distribution of enzymes involved in the metabolism of lipids. Biochim Biophys Acta. 1971 Dec 03; 249(2):395-405. PMID: 4332410.
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    662. Cotman CW, Banker G, Levy W, Taylor D. An ultrastructural and chemical analysis of the effect of triton X-100 on synaptic plasma membranes. Biochim Biophys Acta. 1971 Dec 03; 249(2):406-18. PMID: 4109143.
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    663. Cotman CW, Banker G, Zornetzer SF, McGaugh JL. Electroshock effects on brain protein synthesis: relation to brain seizures and retrograde amnesia. Science. 1971 Jul 30; 173(3995):454-6. PMID: 5104968.
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    664. Cotman CW, Taylor DA. Autoradiographic analysis of protein synthesis in synaptosomal fractions. Brain Res. 1971 Jun 18; 29(2):366-72. PMID: 5116065.
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    665. Banker G, Cotman CW. Characteristics of different amino acids as protein precursors in mouse brain: advantages of certain carboxyl-labeled amino acids. Arch Biochem Biophys. 1971 Feb; 142(2):565-73. PMID: 5550159.
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    666. Cotman CW, Flansburg DA. An analytical micro-method for electron microscopic study of the composition and sedimentation properties of subcellular fractions. Brain Res. 1970 Aug 12; 22(1):152-6. PMID: 5457266.
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    667. Cotman CW, Mahler HR, Hugli TE. Isolation and characterization of insoluble proteins of the synaptic plasma membrane. Arch Biochem Biophys. 1968 Sep 10; 126(3):821-37. PMID: 5686594.
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    668. Cotman CW, Mahler HR. Resolution of insoluble proteins in rat brain subcellular fractions. Arch Biochem Biophys. 1967 May; 120(2):384-96. PMID: 6033455.
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