Carl W. Cotman

Title(s)Professor, Neurology
Address1113 Gillespie Building
Zot 4540
Irvine CA 92697
Phone(949) 824-5847
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    Other Positions
    Title(s)Professor, Neurobiology & Behavior


    Collapse Research 
    Collapse Research Activities and Funding
    Comparative Single-Cell Epigenomic Analysis of AD-like Pathogenesis in Unconventional Animal Models
    NIH R24AG073198Sep 1, 2021 - May 31, 2025
    Role: Co-Principal Investigator
    Single-Cell Analysis of Aging-Associated 4D Nucleome in the Human Hippocampus
    NIH U01DA052769Sep 30, 2020 - Aug 31, 2025
    Role: Co-Principal Investigator
    Epigenomic analysis of neural circuits in Alzheimer's disease mouse models
    NIH R01AG067153Apr 15, 2020 - Mar 31, 2025
    Role: Co-Principal Investigator
    Epigenetic suppression of histone methylation reverses age and AD-related cognitive decline
    NIH/NIA R01AG057558Aug 1, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Epigenetic suppression of histone methylation reverses age and AD-related cognitive decline
    NIH RF1AG057558Aug 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognition
    NIH R01AG051807May 15, 2016 - Jan 31, 2021
    Role: Co-Principal Investigator
    A Novel Approach to Study Synaptic Plasticity in Isolated Synaptosomes using Flow Cytometry
    NIH R21AG048506Sep 1, 2015 - Apr 30, 2018
    Role: Principal Investigator
    Gene Expression, Compensation Mechanisms, and Successful Cognitive Aging
    NIH R01AG034667Aug 15, 2009 - Jul 31, 2015
    Role: Principal Investigator
    Brain Aging &Gene Expression Patterns Using Microarrays
    NIH R01AG023173Sep 30, 2003 - Jul 31, 2009
    Role: Principal Investigator
    ABeta Immunization in Aging
    NIH R01AG020242Sep 30, 2001 - Jul 31, 2007
    Role: Principal Investigator
    APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    NIH R01NS040953Dec 1, 2000 - Nov 30, 2004
    Role: Principal Investigator
    MECHANISMS OF PATHOLOGICAL NEURITIC &SOMAL DEGENERATION
    NIH R01AG017765Sep 30, 2000 - Aug 31, 2003
    Role: Principal Investigator
    The Alzheimer's Disease Research Center at the University of California, Irvine
    NIH P50AG016573Apr 15, 2000 - Mar 31, 2020
    Role: Co-Principal Investigator
    ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    NIH R01AG013411Sep 30, 1996 - Mar 31, 2005
    Role: Principal Investigator
    The Canine as an Animal Model of Human Aging
    NIH R37AG012694Sep 30, 1995 - May 31, 2019
    Role: Principal Investigator
    CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    NIH R01AG012694Sep 30, 1995 - Aug 31, 2006
    Role: Principal Investigator
    MECHANISMS AND MOLECULAR PROFILES OF DEGENERATION IN AD
    NIH R01AG013007May 25, 1995 - Apr 30, 2001
    Role: Principal Investigator
    GENETIC AND BIOCHEMICAL EVENTS IN AB-INDUCED APOPTOSIS
    NIH R01AG012663Jan 15, 1995 - Dec 31, 1997
    Role: Principal Investigator
    PLASTICITY IN THE DEVELOPING LIMBIC SYSTEM
    NIH R01NS027320Apr 1, 1989 - Mar 31, 1994
    Role: Principal Investigator
    NEURONAL PLASTICITY/PATHOLOGY IN ALZHEIMERS DISEASE
    NIH R35AG007918Jan 1, 1989 - Dec 31, 1995
    Role: Principal Investigator
    Training in the Neurobiology of Aging and Alzheimer's Disease
    NIH T32AG000096Sep 29, 1982 - Apr 30, 2024
    Role: Principal Investigator
    Behavioral and Neural Plasticity in the Aged
    NIH P01AG000538Jan 1, 1977 - Mar 31, 2020
    Role: Principal Investigator
    INTERRELATIONS BETWEEN CHEMICAL &BEHAVIORAL PLASTICITY
    NIH R01MH019691Jan 1, 1977 - Dec 31, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner. Front Aging Neurosci. 2021; 13:798297. Ionescu-Tucker A, Butler CW, Berchtold NC, Matheos DP, Wood MA, Cotman CW. PMID: 34970138; PMCID: PMC8712855.
      View in: PubMed   Mentions:
    2. Emerging roles of oxidative stress in brain aging and Alzheimer's disease. Neurobiol Aging. 2021 Jul 25; 107:86-95. Ionescu-Tucker A, Cotman CW. PMID: 34416493.
      View in: PubMed   Mentions:    Fields:    
    3. Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial. Alzheimers Dement. 2021 Jul 23. Shadyab AH, LaCroix AZ, Feldman HH, van Dyck CH, Okonkwo OC, Tam SP, Fairchild JK, Welsh-Bohmer KA, Matthews G, Bennett D, Shadyab AA, Schafer KA, Morrison RH, Kipperman SA, Mason J, Tan D, Thomas RG, Cotman CW, Baker LD, ADCS EXERT Study Group. PMID: 34297895.
      View in: PubMed   Mentions:    Fields:    
    4. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2020 10 23; 11(1):5370. McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. PMID: 33097708; PMCID: PMC7584603.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    5. Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec. Alzheimers Dement (N Y). 2020; 6(1):e12059. Jacobs DM, Thomas RG, Salmon DP, Jin S, Feldman HH, Cotman CW, Baker LD, Alzheimer's Disease Cooperative Study EXERT Study Group, Alzheimer's Disease Neuroimaging Initiative. PMID: 32995469; PMCID: PMC7507362.
      View in: PubMed   Mentions:
    6. miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13118. Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. PMID: 32087004; PMCID: PMC7059142.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    7. Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity. Learn Mem. 2019 12; 26(12):485-492. Butler CW, Keiser AA, Kwapis JL, Berchtold NC, Wall VL, Wood MA, Cotman CW. PMID: 31732709; PMCID: PMC6859826.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 11 04; 9(1):15936. Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. PMID: 31685865; PMCID: PMC6828807.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. Alzheimer Dis Assoc Disord. 2019 Oct-Dec; 33(4):327-330. Ayer AH, Wojta K, Ramos EM, Dokuru D, Chen JA, Karydas AM, Papatriantafyllou JD, Agiomyrgiannakis D, Kamtsadeli V, Tsinia N, Sali D, Gylys KH, Agosta F, Filippi M, Small GW, Bennett DA, Gearing M, Juncos JL, Kramer J, Lee SE, Yokoyama JS, Mendez MF, Chui H, Zarow C, Ringman JM, Kilic U, Babacan-Yildiz G, Levey A, DeCarli CS, Cotman CW, Boxer AL, Miller BL, Coppola G. PMID: 31513029; PMCID: PMC7050643.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. What are the earlier life contributions to reserve and resilience? Neurobiol Aging. 2019 11; 83:135-139. Walhovd KB, Howell GR, Ritchie SJ, Staff RT, Cotman CW. PMID: 31307838.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models. Aging Cell. 2019 06; 18(3):e12919. Trujillo-Estrada L, Nguyen C, da Cunha C, Cai L, Forner S, Martini AC, Ager RR, Prieto GA, Cotman CW, Baglietto-Vargas D, LaFerla FM. PMID: 30809950; PMCID: PMC6516168.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline. Neurobiol Aging. 2019 06; 78:142-154. Berchtold NC, Prieto GA, Phelan M, Gillen DL, Baldi P, Bennett DA, Buchman AS, Cotman CW. PMID: 30927700; PMCID: PMC6901108.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites. ACS Chem Neurosci. 2019 03 20; 10(3):1197-1203. Prieto GA, Smith ED, Tong L, Nguyen M, Cotman CW. PMID: 30695637.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018 08; 17(4):e12791. Baglietto-Vargas D, Prieto GA, Limon A, Forner S, Rodriguez-Ortiz CJ, Ikemura K, Ager RR, Medeiros R, Trujillo-Estrada L, Martini AC, Kitazawa M, Davila JC, Cotman CW, Gutierrez A, LaFerla FM. PMID: 29877034; PMCID: PMC6052400.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    15. Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines. Brain Pathol. 2018 05; 28(3):427-430. Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. PMID: 29740941; PMCID: PMC8028592.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    16. IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation. J Neuroinflammation. 2018 Apr 30; 15(1):127. Tong L, Prieto GA, Cotman CW. PMID: 29712570; PMCID: PMC5925843.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse. Neurochem Res. 2019 Jan; 44(1):49-60. Prieto GA, Tong L, Smith ED, Cotman CW. PMID: 29619614; PMCID: PMC6170724.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    18. On the road towards the global analysis of human synapses. Neural Regen Res. 2017 Oct; 12(10):1586-1589. Prieto GA, Cotman CW. PMID: 29171413; PMCID: PMC5696829.
      View in: PubMed   Mentions: 2  
    19. Cytokines and cytokine networks target neurons to modulate long-term potentiation. Cytokine Growth Factor Rev. 2017 Apr; 34:27-33. Prieto GA, Cotman CW. PMID: 28377062; PMCID: PMC5491344.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    20. Pattern separation and goal-directed behavior in the aged canine. Learn Mem. 2017 03; 24(3):123-131. Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW. PMID: 28202716; PMCID: PMC5311386.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    21. IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking. J Neuroinflammation. 2017 02 02; 14(1):29. Carlos AJ, Tong L, Prieto GA, Cotman CW. PMID: 28153028; PMCID: PMC5290618.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. J Neurosci. 2017 02 01; 37(5):1197-1212. Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW. PMID: 27986924; PMCID: PMC5296796.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise. J Neuroinflammation. 2016 11 10; 13(1):289. Abbasi A, de Paula Vieira R, Bischof F, Walter M, Movassaghi M, Berchtold NC, Niess AM, Cotman CW, Northoff H. PMID: 27832807; PMCID: PMC5105243.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. J Neurosci. 2016 Mar 23; 36(12):3611-22. Snigdha S, Prieto GA, Petrosyan A, Loertscher BM, Dieskau AP, Overman LE, Cotman CW. PMID: 27013689; PMCID: PMC4804016.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    25. Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer's Disease: A Randomized Controlled Trial. J Alzheimers Dis. 2016; 50(2):443-53. Hoffmann K, Sobol NA, Frederiksen KS, Beyer N, Vogel A, Vestergaard K, Brændgaard H, Gottrup H, Lolk A, Wermuth L, Jacobsen S, Laugesen LP, Gergelyffy RG, Høgh P, Bjerregaard E, Andersen BB, Siersma V, Johannsen P, Cotman CW, Waldemar G, Hasselbalch SG. PMID: 26682695.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    26. Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiol Aging. 2016 Jan; 37:171-178. Snigdha S, de Rivera C, Milgram NW, Cotman CW. PMID: 26481404.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    27. Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5078-87. Prieto GA, Snigdha S, Baglietto-Vargas D, Smith ED, Berchtold NC, Tong L, Ajami D, LaFerla FM, Rebek J, Cotman CW. PMID: 26305968; PMCID: PMC4568670.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    28. Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem. 2014 Jul 25; 289(30):20615-29. Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW. PMID: 24917666; PMCID: PMC4110274.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    29. Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer's disease. Neurobiol Aging. 2014 Sep; 35(9):1961-72. Berchtold NC, Sabbagh MN, Beach TG, Kim RC, Cribbs DH, Cotman CW. PMID: 24786631; PMCID: PMC4067010.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    30. Exercise enhances memory consolidation in the aging brain. Front Aging Neurosci. 2014; 6:3. Snigdha S, de Rivera C, Milgram NW, Cotman CW. PMID: 24550824; PMCID: PMC3910002.
      View in: PubMed   Mentions: 20  
    31. Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production. Neurobiol Aging. 2014 May; 35(5):1002-11. Rice RA, Berchtold NC, Cotman CW, Green KN. PMID: 24268883; PMCID: PMC3939046.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design. Neuroepidemiology. 2013; 41(3-4):198-207. Hoffmann K, Frederiksen KS, Sobol NA, Beyer N, Vogel A, Simonsen AH, Johannsen P, Lolk A, Terkelsen O, Cotman CW, Hasselbalch SG, Waldemar G. PMID: 24135720.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    33. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. Am J Pathol. 2013 Aug; 183(2):369-81. Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. PMID: 23747948; PMCID: PMC3730768.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    34. Exercise and sodium butyrate transform a subthreshold learning event into long-term memory via a brain-derived neurotrophic factor-dependent mechanism. Neuropsychopharmacology. 2013 Sep; 38(10):2027-34. Intlekofer KA, Berchtold NC, Malvaez M, Carlos AJ, McQuown SC, Cunningham MJ, Wood MA, Cotman CW. PMID: 23615664; PMCID: PMC3746687.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    35. β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. J Biol Chem. 2013 Jun 07; 288(23):16937-16948. Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW. PMID: 23599427; PMCID: PMC3675626.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    36. A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiol Aging. 2013 Jul; 34(7):1891-901. Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW. PMID: 23434040; PMCID: PMC3650917.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    37. Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease. Neurobiol Aging. 2013 Jun; 34(6):1653-61. Berchtold NC, Coleman PD, Cribbs DH, Rogers J, Gillen DL, Cotman CW. PMID: 23273601; PMCID: PMC4022280.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    38. Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase. J Neurosci. 2012 Dec 05; 32(49):17714-24. Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW. PMID: 23223292; PMCID: PMC3687587.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    39. Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year. Arch Gerontol Geriatr. 2013 Jan-Feb; 56(1):96-103. Winchester J, Dick MB, Gillen D, Reed B, Miller B, Tinklenberg J, Mungas D, Chui H, Galasko D, Hewett L, Cotman CW. PMID: 22959822; PMCID: PMC3766353.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCTClinical Trials
    40. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 2012 Jul 23; 9:179. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW. PMID: 22824372; PMCID: PMC3419089.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
    41. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease. Neurobiol Dis. 2013 Sep; 57:47-55. Intlekofer KA, Cotman CW. PMID: 22750524.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    42. Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. ACS Chem Neurosci. 2012 Jun 20; 3(6):433-8. Kim HJ, Park JW, Byun JH, Poon WW, Cotman CW, Fowlkes CC, Jeon NL. PMID: 24358503; PMCID: PMC3643179.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    43. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N, Alzheimer's Disease Genetics Consortium (ADGC), Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach T, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Crane PK, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dombroski BA, Duara R, Ellis WD, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch M, Galasko DR, Gallins PJ, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JS, Kaye JA, Kennedy N, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Myers AJ, Naj AC, Nowotny P, Parisi JE, Perl DP, Peskind E, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL. PMID: 22722634; PMCID: PMC3398432.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    44. Clinical trials: new opportunities. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):773-80. Chapman SB, Cotman CW, Fillit HM, Gallagher M, van Dyck CH. PMID: 22570132; PMCID: PMC3708514.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    45. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Alzheimer's Disease Genetics Consortium, Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E, Geschwind DH. PMID: 22556362; PMCID: PMC3392107.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    46. Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull. 2012 Feb; 28(1):14-24. Snigdha S, Smith ED, Prieto GA, Cotman CW. PMID: 22233886; PMCID: PMC3838299.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    47. Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in ɛ4 carriers. Alzheimers Dement. 2012 Jul; 8(4):352-6. Deeny SP, Winchester J, Nichol K, Roth SM, Wu JC, Dick M, Cotman CW. PMID: 22226798; PMCID: PMC3360109.
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    48. Exercise-induced noradrenergic activation enhances memory consolidation in both normal aging and patients with amnestic mild cognitive impairment. J Alzheimers Dis. 2012; 32(4):1011-8. Segal SK, Cotman CW, Cahill LF. PMID: 22914593; PMCID: PMC3951984.
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    49. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 2012 Jan 27; 202:326-33. Snigdha S, Astarita G, Piomelli D, Cotman CW. PMID: 22183056; PMCID: PMC3447971.
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    50. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 22046234; PMCID: PMC3202527.
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    51. Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. PLoS One. 2011; 6(9):e24652. Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW. PMID: 21931796; PMCID: PMC3172245.
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    52. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. PMID: 21546126; PMCID: PMC3154439.
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    53. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. PMID: 21460841; PMCID: PMC3090745.
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    54. Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordr). 2012 Feb; 34(1):67-73. Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW. PMID: 21336566; PMCID: PMC3260365.
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    55. Mild stress facilitates learning and exercise improves retention in aged mice. Exp Gerontol. 2011 Jan; 46(1):53-9. Adlard PA, Engesser-Cesar C, Cotman CW. PMID: 20951791.
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    56. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010 Sep 08; 5(9):e12538. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. PMID: 20838618; PMCID: PMC2935886.
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    57. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci. 2010 Jul 21; 30(29):9831-9. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. PMID: 20660265; PMCID: PMC3769160.
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    58. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis. 2010 Sep; 39(3):301-10. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. PMID: 20451612; PMCID: PMC2910127.
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    59. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012 Mar; 33(3):546-54. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. PMID: 20447733; PMCID: PMC2935515.
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    60. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. PMID: 20434811; PMCID: PMC2932860.
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    61. Exercise and time-dependent benefits to learning and memory. Neuroscience. 2010 May 19; 167(3):588-97. Berchtold NC, Castello N, Cotman CW. PMID: 20219647; PMCID: PMC2857396.
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    62. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. PMID: 20154673; PMCID: PMC2828525.
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    63. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. PMID: 20463402; PMCID: PMC4175722.
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    64. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19150-5. Acharya MM, Christie LA, Lan ML, Donovan PJ, Cotman CW, Fike JR, Limoli CL. PMID: 19901336; PMCID: PMC2776427.
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    65. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec; 44(12):752-9. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. PMID: 19735717; PMCID: PMC2787885.
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    66. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol. 2009 Nov; 220(1):171-6. Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. PMID: 19703441; PMCID: PMC2761532.
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    67. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement. 2009 Jul; 5(4):287-94. Nichol K, Deeny SP, Seif J, Camaclang K, Cotman CW. PMID: 19560099; PMCID: PMC4105011.
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    68. β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiol Aging. 2011 May; 32(5):821-33. Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. PMID: 19540623; PMCID: PMC3038182.
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    69. Axonal mRNA in uninjured and regenerating cortical mammalian axons. J Neurosci. 2009 Apr 15; 29(15):4697-707. Taylor AM, Berchtold NC, Perreau VM, Tu CH, Li Jeon N, Cotman CW. PMID: 19369540; PMCID: PMC3632375.
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    70. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec; 15(4):685-707. Cotman CW, Head E. PMID: 19096165.
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    71. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol. 2008 Nov 10; 511(2):257-70. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. PMID: 18792072; PMCID: PMC4105010.
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    72. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009 Apr; 34(4):755-63. Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J. PMID: 18846423; PMCID: PMC2790461.
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    73. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15605-10. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. PMID: 18832152; PMCID: PMC2563070.
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    74. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation. 2008 Apr 09; 5:13. Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW. PMID: 18400101; PMCID: PMC2329612.
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    75. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2008 Apr 01; 44(7):1465-74. Li X, Liu Z, Luo C, Jia H, Sun L, Hou B, Shen W, Packer L, Cotman CW, Liu J. PMID: 18258206; PMCID: PMC2597696.
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    76. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiol Dis. 2008 Apr; 30(1):121-9. Parachikova A, Nichol KE, Cotman CW. PMID: 18258444; PMCID: PMC2386749.
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    77. R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia. 2008 Jan; 51(1):165-74. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, Liu J. PMID: 18026715.
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    78. Voluntary running attenuates age-related deficits following SCI. Exp Neurol. 2008 Mar; 210(1):207-16. Siegenthaler MM, Berchtold NC, Cotman CW, Keirstead HS. PMID: 18164294; PMCID: PMC2387276.
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    79. Non-plasma bonding of PDMS for inexpensive fabrication of microfluidic devices. J Vis Exp. 2007; (9):410. Harris J, Lee H, Vahidi B, Tu C, Cribbs D, Cotman C, Jeon NL. PMID: 18989450; PMCID: PMC2566327.
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    80. Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons. Brain Res. 2008 Jan 10; 1188:189-97. Soiampornkul R, Tong L, Thangnipon W, Balazs R, Cotman CW. PMID: 18036576; PMCID: PMC2409119.
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    81. Preparing e18 cortical rat neurons for compartmentalization in a microfluidic device. J Vis Exp. 2007; (8):305. Harris J, Lee H, Tu CT, Cribbs D, Cotman C, Jeon NL. PMID: 18989412; PMCID: PMC2562488.
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    82. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. PMID: 17897471; PMCID: PMC2100048.
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    83. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007 Sep; 30(9):464-72. Cotman CW, Berchtold NC, Christie LA. PMID: 17765329.
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    84. Fabrication of a microfluidic device for the compartmentalization of neuron soma and axons. J Vis Exp. 2007; (7):261. Harris J, Lee H, Vahidi B, Tu C, Cribbs D, Jeon NL, Cotman C. PMID: 18989432; PMCID: PMC2565860.
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    85. Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res. 2007 Dec 03; 184(2):124-32. Nichol KE, Parachikova AI, Cotman CW. PMID: 17698211; PMCID: PMC2215770.
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    86. Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease. Neurobiol Dis. 2007 Nov; 28(2):143-53. Parachikova A, Cotman CW. PMID: 17764962; PMCID: PMC2198928.
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    87. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem. 2007 Sep; 88(2):249-59. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. PMID: 17587610; PMCID: PMC2173881.
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    88. Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol Aging. 2008 Sep; 29(9):1380-93. Tong L, Balazs R, Soiampornkul R, Thangnipon W, Cotman CW. PMID: 17467122; PMCID: PMC4052889.
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    89. Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr; 25(7):1931-9. Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW, Anderson AJ. PMID: 17439482.
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    90. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement. 2007 Apr; 3(2 Suppl):S30-7. Cotman CW, Berchtold NC. PMID: 19595972.
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    91. External force-assisted cell positioning inside microfluidic devices. Biomed Microdevices. 2007 Feb; 9(1):15-23. Rhee SW, Taylor AM, Cribbs DH, Cotman CW, Jeon NL. PMID: 17091393.
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    92. Beta-amyloid causes downregulation of calcineurin in neurons through induction of oxidative stress. Neurobiol Dis. 2007 May; 26(2):342-52. Celsi F, Svedberg M, Unger C, Cotman CW, Carrì MT, Ottersen OP, Nordberg A, Torp R. PMID: 17344052.
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    93. Differential regulation of inhibitors of apoptosis proteins in Alzheimer's disease brains. Neurobiol Dis. 2007 Apr; 26(1):165-73. Christie LA, Su JH, Tu CH, Dick MC, Zhou J, Cotman CW. PMID: 17292615; PMCID: PMC2198925.
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    94. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):339-48. Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J. PMID: 17197552; PMCID: PMC2597695.
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    95. Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord. Neuroscience. 2007 Feb 09; 144(3):1033-44. Engesser-Cesar C, Anderson AJ, Cotman CW. PMID: 17137724.
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    96. Effects of melatonin and age on gene expression in mouse CNS using microarray analysis. Neurochem Int. 2007 Jan; 50(2):336-44. Sharman EH, Bondy SC, Sharman KG, Lahiri D, Cotman CW, Perreau VM. PMID: 17118492; PMCID: PMC1868445.
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    97. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan; 29(1):39-50. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. PMID: 17092609; PMCID: PMC2198929.
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    98. Melatonin treatment in old mice enables a more youthful response to LPS in the brain. J Neuroimmunol. 2007 Jan; 182(1-2):22-31. Perreau VM, Bondy SC, Cotman CW, Sharman KG, Sharman EH. PMID: 17070935; PMCID: PMC1847646.
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    99. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan; 29(1):51-70. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. PMID: 17055614; PMCID: PMC2203613.
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    100. Inflammatory changes parallel the early stages of Alzheimer disease. Neurobiol Aging. 2007 Dec; 28(12):1821-33. Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW. PMID: 17052803; PMCID: PMC2198930.
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    101. Musashi1 antigen expression in human fetal germinal matrix development. Exp Neurol. 2006 Oct; 201(2):515-8. Chan C, Moore BE, Cotman CW, Okano H, Tavares R, Hovanesian V, Pinar H, Johanson CE, Svendsen CN, Stopa EG. PMID: 16777095.
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    102. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem. 2006 Sep; 86(2):197-204. Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. PMID: 16616528.
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    103. Neurobiology of exercise. Obesity (Silver Spring). 2006 Mar; 14(3):345-56. Dishman RK, Berthoud HR, Booth FW, Cotman CW, Edgerton VR, Fleshner MR, Gandevia SC, Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, Levin BE, Moran TH, Russo-Neustadt AA, Salamone JD, Van Hoomissen JD, Wade CE, York DA, Zigmond MJ. PMID: 16648603.
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    104. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 Apr 05; 24(15):2824-34. Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. PMID: 16460841.
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    105. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. PMID: 16271803.
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    106. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005 Sep 01; 227(5):722-8. Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. PMID: 16178393.
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    107. A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods. 2005 Aug; 2(8):599-605. Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL. PMID: 16094385; PMCID: PMC1558906.
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    108. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. PMID: 15986225.
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    109. The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo. Neurochem Res. 2005 Jun-Jul; 30(6-7):877-81. Cotman CW. PMID: 16187222.
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    110. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordr). 2005 Mar; 27(1):27-37. Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. PMID: 23598601; PMCID: PMC3456092.
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    111. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 2005 May; 26(5):749-63. Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. PMID: 15708450.
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    112. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Apr 27; 25(17):4217-21. Adlard PA, Perreau VM, Pop V, Cotman CW. PMID: 15858047; PMCID: PMC6725122.
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    113. The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging. 2005 Apr; 26(4):511-20. Adlard PA, Perreau VM, Cotman CW. PMID: 15653179.
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    114. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):361-9. Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. PMID: 15795044.
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    115. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):461-9. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. PMID: 15795055.
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    116. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15751224.
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    117. Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma. 2005 Jan; 22(1):157-71. Engesser-Cesar C, Anderson AJ, Basso DM, Edgerton VR, Cotman CW. PMID: 15665610.
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    118. Exercise-induced gene expression changes in the rat spinal cord. Gene Expr. 2005; 12(2):107-21. Perreau VM, Adlard PA, Anderson AJ, Cotman CW. PMID: 15892452; PMCID: PMC6009109.
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    119. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience. 2005; 133(3):853-61. Berchtold NC, Chinn G, Chou M, Kesslak JP, Cotman CW. PMID: 15896913.
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    120. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging. 2005 Jan; 26(1):77-90. Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. PMID: 15585348.
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    121. Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma. 2004 Dec; 21(12):1831-46. Anderson AJ, Robert S, Huang W, Young W, Cotman CW. PMID: 15684772.
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    122. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci. 2004 Nov; 1033:117-31. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. PMID: 15591009.
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    123. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004 Sep 22; 24(38):8205-13. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. PMID: 15385603; PMCID: PMC6729694.
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    124. Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury. J Neurosci Res. 2004 Sep 01; 77(5):701-8. Glaser J, Gonzalez R, Perreau VM, Cotman CW, Keirstead HS. PMID: 15352216.
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    125. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res. 2004 Aug 12; 153(1):199-210. Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. PMID: 15219721.
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    126. Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci. 2004 Jul 28; 24(30):6799-809. Tong L, Balazs R, Thornton PL, Cotman CW. PMID: 15282285; PMCID: PMC6729714.
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    127. Patterned cell culture inside microfluidic devices. Lab Chip. 2005 Jan; 5(1):102-7. Rhee SW, Taylor AM, Tu CH, Cribbs DH, Cotman CW, Jeon NL. PMID: 15616747.
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    128. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619; PMCID: PMC437967.
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    129. The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett. 2004 Jun 03; 363(1):43-8. Adlard PA, Perreau VM, Engesser-Cesar C, Cotman CW. PMID: 15157993.
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    130. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004 May; 39(5):753-65. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. PMID: 15130670.
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    131. Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord. 2004; 17(4):360-7. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. PMID: 15178954; PMCID: PMC2637356.
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    132. Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression. Neuroscience. 2004; 124(4):985-92. Adlard PA, Cotman CW. PMID: 15026138.
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    133. Oligodendrocyte degeneration in AD. Neurobiol Aging. 2004 Jan; 25(1):33-6. Whitman GT, Cotman CW. PMID: 14675727.
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    134. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology. 2003 Dec 23; 61(12):1673-9. Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. PMID: 14694028.
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    135. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. Zhao M, Su J, Head E, Cotman CW. PMID: 14678756.
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    136. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. PMID: 14570555.
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    137. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. Bi X, Head E, Cotman CW, Lynch G. PMID: 12900930.
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    138. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. J Neuropathol Exp Neurol. 2003 Sep; 62(9):917-26. Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. PMID: 14533781.
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    139. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. PMID: 12931965.
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    140. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 2003 May 09; 971(2):239-44. Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ. PMID: 12706240.
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    141. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. PMID: 12702875.
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    142. Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis. 2003 Apr; 12(3):182-93. Su JH, Anderson AJ, Cribbs DH, Tu C, Tong L, Kesslack P, Cotman CW. PMID: 12742739.
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    143. Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid. Int Immunol. 2003 Apr; 15(4):505-14. Cribbs DH, Ghochikyan A, Vasilevko V, Tran M, Petrushina I, Sadzikava N, Babikyan D, Kesslak P, Kieber-Emmons T, Cotman CW, Agadjanyan MG. PMID: 12663680; PMCID: PMC1483061.
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    144. Microfluidic Multicompartment Device for Neuroscience Research. Langmuir. 2003 Mar 04; 19(5):1551-1556. Taylor AM, Rhee SW, Tu CH, Cribbs DH, Cotman CW, Jeon NL. PMID: 20725530; PMCID: PMC2923462.
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    145. The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res. 2003 Feb; 28(2):307-18. Zhao M, Cribbs DH, Anderson AJ, Cummings BJ, Su JH, Wasserman AJ, Cotman CW. PMID: 12608703.
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    146. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. PMID: 12551965; PMCID: PMC196651.
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    147. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. 2003; 119(3):721-32. Garcia C, Chen MJ, Garza AA, Cotman CW, Russo-Neustadt A. PMID: 12809693.
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    148. Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. Neuroscience. 2003; 120(2):291-300. Torp R, Ottersen OP, Cotman CW, Head E. PMID: 12890502.
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    149. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. PMID: 12480733.
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    150. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. PMID: 12505426.
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    151. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
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    152. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci Biobehav Rev. 2002 Oct; 26(6):679-95. Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada J, Ikeda-Douglas CJ, Zicker SC, Cotman CW. PMID: 12479842.
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    153. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. PMID: 12213643.
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    154. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. PMID: 12392784.
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    155. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging. 2002 Sep-Oct; 23(5):737-45. Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW. PMID: 12392778.
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    156. Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Arch Gen Psychiatry. 2002 Aug; 59(8):705-12. Albert KA, Hemmings HC, Adamo AI, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P. PMID: 12150646.
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    157. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul; 77(7):681-96. Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. PMID: 12108606.
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    158. Oxidative damage increases with age in a canine model of human brain aging. J Neurochem. 2002 Jul; 82(2):375-81. Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. PMID: 12124438.
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    159. Hippocampal brain-derived neurotrophic factor gene regulation by exercise and the medial septum. J Neurosci Res. 2002 Jun 01; 68(5):511-21. Berchtold NC, Kesslak JP, Cotman CW. PMID: 12111841.
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    160. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002 Jun; 25(6):295-301. Cotman CW, Berchtold NC. PMID: 12086747.
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    161. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. PMID: 12049325.
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    162. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. Su JH, Kesslak JP, Head E, Cotman CW. PMID: 12070657.
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    163. Exercise enhances and protects brain function. Exerc Sport Sci Rev. 2002 Apr; 30(2):75-9. Cotman CW, Engesser-Cesar C. PMID: 11991541.
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    164. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. PMID: 11854529; PMCID: PMC122369.
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    165. Brainstem and cortical Lewy bodies in patients presenting clinically with Alzheimer's disease. J Alzheimers Dis. 2002 Feb; 4(1):11-7. SantaCruz KS, Tasaki CS, Kim RC, Cotman CW. PMID: 12214014.
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    166. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94. Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. PMID: 12025818.
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    167. Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus. Eur J Neurosci. 2001 Dec; 14(12):1992-2002. Berchtold NC, Kesslak JP, Pike CJ, Adlard PA, Cotman CW. PMID: 11860494.
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    168. Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis. 2001 Dec; 8(6):1046-56. Tong L, Shen H, Perreau VM, Balazs R, Cotman CW. PMID: 11741400.
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    169. Activation of caspase-8 in the Alzheimer's disease brain. Neurobiol Dis. 2001 Dec; 8(6):1006-16. Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH. PMID: 11741396.
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    170. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct; 8(5):792-806. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. PMID: 11592849.
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    171. Estrogen regulates bcl-x expression in rat hippocampus. Neuroreport. 2001 Sep 17; 12(13):2797-800. Stoltzner SE, Berchtold NC, Cotman CW, Pike CJ. PMID: 11588579.
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    172. Bcl-2 family protein behavior in frontotemporal dementia implies vascular involvement. Neurology. 2001 Jun; 56(11 Suppl 4):S35-40. Nichol KE, Kim R, Cotman CW. PMID: 11402149.
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    173. Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res. 2001 Apr 20; 898(2):350-7. Su JH, Zhao M, Anderson AJ, Srinivasan A, Cotman CW. PMID: 11306022.
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    174. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiol Dis. 2001 Apr; 8(2):252-65. Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. PMID: 11300721.
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    175. 15-deoxy-delta12,14-prostaglandin J2, a specific ligand for peroxisome proliferator-activated receptor-gamma, induces neuronal apoptosis. Neuroreport. 2001 Mar 26; 12(4):839-43. Rohn TT, Wong SM, Cotman CW, Cribbs DH. PMID: 11277593.
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    176. Astrocytes degenerate in frontotemporal dementia: possible relation to hypoperfusion. Neurobiol Aging. 2001 Mar-Apr; 22(2):195-207. Martin JA, Craft DK, Su JH, Kim RC, Cotman CW. PMID: 11182469.
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    177. Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. J Biol Chem. 2001 May 18; 276(20):17301-6. Tong L, Thornton PL, Balazs R, Cotman CW. PMID: 11278679.
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    178. Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus. Neuroscience. 2001; 107(2):219-29. Shen H, Tong L, Balazs R, Cotman CW. PMID: 11731096.
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    179. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am J Pathol. 2001 Jan; 158(1):189-98. Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. PMID: 11141492; PMCID: PMC1850275.
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    180. The variability of practice hypothesis in motor learning: does it apply to Alzheimer's disease? Brain Cogn. 2000 Dec; 44(3):470-89. Dick MB, Hsieh S, Dick-Muehlke C, Davis DS, Cotman CW. PMID: 11104538.
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    181. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):777-86. Head E, Thornton PL, Tong L, Cotman CW. PMID: 11191712.
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    182. Canine cognition, aging and neuropathology. Introduction. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):671-3. Head E, Cotman CW, Milgram NW. PMID: 11191707.
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    183. Development of a protocol for studying object recognition memory in the dog. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):693-707. Callahan H, Ikeda-Douglas C, Head E, Cotman CW, Milgram NW. PMID: 11191709.
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    184. Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul; 24(5):801-10. Torp R, Head E, Cotman CW. PMID: 11191714.
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    185. Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures. Glia. 2000 Jun; 30(4):352-61. Ulas J, Satou T, Ivins KJ, Kesslak JP, Cotman CW, Balázs R. PMID: 10797615.
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    186. A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J Neurochem. 2000 Jun; 74(6):2331-42. Rohn TT, Ivins KJ, Bahr BA, Cotman CW, Cribbs DH. PMID: 10820193.
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    187. Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. Biochemistry. 2000 May 23; 39(20):5988-94. Cribbs DH, Azizeh BY, Cotman CW, LaFerla FM. PMID: 10821670.
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    188. DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia. Exp Neurol. 2000 May; 163(1):9-19. Su JH, Nichol KE, Sitch T, Sheu P, Chubb C, Miller BL, Tomaselli KJ, Kim RC, Cotman CW. PMID: 10785439.
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    189. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Exp Neurol. 2000 May; 163(1):111-22. Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. PMID: 10785449.
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    190. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA. 2000 Feb 23; 283(8):1007-15. Mulnard RA, Cotman CW, Kawas C, van Dyck CH, Sano M, Doody R, Koss E, Pfeiffer E, Jin S, Gamst A, Grundman M, Thomas R, Thal LJ. PMID: 10697060.
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    191. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behav Brain Res. 2000 Feb; 108(1):47-56. Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. PMID: 10680756.
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    192. The brain's microenvironment, early functional loss, and the conversion to Alzheimer's disease. Ann N Y Acad Sci. 2000; 924:112-6. Cotman CW, Anderson AJ. PMID: 11193787.
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    193. Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging. 2000 Jan-Feb; 21(1):89-96. Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. PMID: 10794853.
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    194. Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience. 2000; 101(2):305-12. Russo-Neustadt AA, Beard RC, Huang YM, Cotman CW. PMID: 11074154.
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    195. Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Neuroscience. 2000; 96(3):495-506. Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. PMID: 10717430.
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    196. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 1999 Nov; 21(5):679-82. Russo-Neustadt A, Beard RC, Cotman CW. PMID: 10516964.
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    197. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol. 1999 Oct; 56(10):1233-9. Johnson JK, Head E, Kim R, Starr A, Cotman CW. PMID: 10520939.
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    198. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Neurobiol Dis. 1999 Oct; 6(5):440-9. Ivins KJ, Thornton PL, Rohn TT, Cotman CW. PMID: 10527810.
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    199. Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. Amyloid. 1999 Sep; 6(3):157-64. Davis J, Cribbs DH, Cotman CW, Van Nostrand WE. PMID: 10524279.
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    200. Bcl-2 facilitates recovery from DNA damage after oxidative stress. Exp Neurol. 1999 Sep; 159(1):309-18. Deng G, Su JH, Ivins KJ, Van Houten B, Cotman CW. PMID: 10486199.
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    201. Sequence of neurodegeneration and accumulation of phosphorylated tau in cultured neurons after okadaic acid treatment. Brain Res. 1999 Aug 28; 839(2):253-62. Kim D, Su J, Cotman CW. PMID: 10519048.
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    202. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain Res Mol Brain Res. 1999 Jul 23; 71(1):11-22. Berchtold NC, Oliff HS, Isackson P, Cotman CW. PMID: 10407182.
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    203. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Exp Neurol. 1999 Jun; 157(2):277-88. Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. PMID: 10364440.
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    204. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem. 1999 Mar; 72(3):1061-8. Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. PMID: 10037477.
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    205. Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid. J Biol Chem. 1999 Jan 22; 274(4):2107-12. Ivins KJ, Ivins JK, Sharp JP, Cotman CW. PMID: 9890971.
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    206. Landmark discrimination learning in the dog. Learn Mem. 1999 Jan-Feb; 6(1):54-61. Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. PMID: 10355524; PMCID: PMC311280.
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    207. Enhancement of spatial-temporal reasoning after a Mozart listening condition in Alzheimer's disease: a case study. Neurol Res. 1998 Dec; 20(8):666-72. Johnson JK, Cotman CW, Tasaki CS, Shaw GL. PMID: 9864729.
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    208. Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis. Neurobiol Dis. 1998 Nov; 5(5):365-78. Ivins KJ, Bui ET, Cotman CW. PMID: 10069579.
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    209. Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol. 1998 Nov; 96(5):463-71. Su JH, Cummings BJ, Cotman CW. PMID: 9829809.
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    210. Preserved cerebellar tyrosine hydroxylase-immunoreactive neuronal fibers in a behaviorally aggressive subgroup of Alzheimer's disease patients. Neuroscience. 1998 Nov; 87(1):55-61. Russo-Neustadt A, Zomorodian TJ, Cotman CW. PMID: 9722141.
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    211. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res Mol Brain Res. 1998 Oct 30; 61(1-2):147-53. Oliff HS, Berchtold NC, Isackson P, Cotman CW. PMID: 9795193.
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    212. GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro. Neurobiol Dis. 1998 Oct; 5(4):245-52. Torp R, Su JH, Deng G, Cotman CW. PMID: 9848094.
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    213. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging. 1998 Sep-Oct; 19(5):479-85. Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. PMID: 9880050.
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    214. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging. 1998 Sep-Oct; 19(5):415-25. Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. PMID: 9880044.
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    215. Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease. Neuroreport. 1998 Aug 03; 9(11):2443-6. Eckert A, Cotman CW, Zerfass R, Hennerici M, Müller WE. PMID: 9721911.
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    216. Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance? Behav Neurosci. 1998 Aug; 112(4):1012-9. Kesslak JP, So V, Choi J, Cotman CW, Gomez-Pinilla F. PMID: 9733207.
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    217. Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration. Prog Neurobiol. 1998 Aug; 55(6):577-94. Sheetz MP, Pfister KK, Bulinski JC, Cotman CW. PMID: 9670219.
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    218. Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations? Prog Neurobiol. 1998 Aug; 55(6):659-69. Cotman CW, Hailer NP, Pfister KK, Soltesz I, Schachner M. PMID: 9670224.
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    219. Microlithographic determination of axonal/dendritic polarity in cultured hippocampal neurons. J Neurosci Methods. 1998 Aug 01; 82(2):167-73. Stenger DA, Hickman JJ, Bateman KE, Ravenscroft MS, Ma W, Pancrazio JJ, Shaffer K, Schaffner AE, Cribbs DH, Cotman CW. PMID: 9700689.
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    220. Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profiles. Brain Res. 1998 Jul 06; 798(1-2):18-24. Johnson JK, McCleary R, Oshita MH, Cotman CW. PMID: 9666062.
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    221. Cross-linking of NCAM receptors on neurons induces programmed cell death. Brain Res. 1998 Jun 15; 796(1-2):20-6. Azizeh BY, Cribbs DH, Kreng VM, Cotman CW. PMID: 9689450.
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    222. Metabotropic glutamate receptor agonists potentiate cyclic AMP formation induced by forskolin or beta-adrenergic receptor activation in cerebral cortical astrocytes in culture. J Neurochem. 1998 Jun; 70(6):2446-58. Balázs R, Miller S, Chun Y, O'Toole J, Cotman CW. PMID: 9603209.
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    223. Receptor-coupled phospholipase C and adenylyl cyclase function with different calcium pools in astrocytes. Neuroreport. 1998 May 11; 9(7):1397-401. Balázs R, Miller S, Chun Y, Cotman CW. PMID: 9631436.
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    224. Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s. Neurobiol Aging. 1998 May-Jun; 19(3):173-89. Berchtold NC, Cotman CW. PMID: 9661992.
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    225. Magnetic resonance imaging relaxation times and gadolinium-DTPA relaxivity values in human cerebrospinal fluid. Invest Radiol. 1998 Mar; 33(3):153-62. Ibrahim MA, Emerson JF, Cotman CW. PMID: 9525754.
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    226. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging. 1998 Jan-Feb; 19(1 Suppl):S29-32. Cotman CW. PMID: 9562464.
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    227. Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered. J Neural Transm Suppl. 1998; 54:259-67. Eckert A, Cotman CW, Zerfass R, Hennerici M, Müller WE. PMID: 9850934.
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    228. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Res. 1997 Nov 07; 774(1-2):35-43. Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. PMID: 9452189.
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    229. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 1997 Nov 07; 774(1-2):193-9. Su JH, Deng G, Cotman CW. PMID: 9452208.
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    230. Open field activity and human interaction as a function of age and breed in dogs. Physiol Behav. 1997 Nov; 62(5):963-71. Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. PMID: 9333188.
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    231. Beta-amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. J Neurochem. 1997 Oct; 69(4):1601-11. Pike CJ, Ramezan-Arab N, Cotman CW. PMID: 9326289.
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    232. Amyloid deposition in cerebrovascular angiopathy. Ann N Y Acad Sci. 1997 Sep 26; 826:463-71. de Figueiredo RJ, Oten R, Su J, Cotman CW. PMID: 9329725.
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    233. Life-long dietary restriction attenuates age-related increases in hippocampal glial fibrillary acidic protein mRNA. Neurobiol Aging. 1997 Sep-Oct; 18(5):523-6. Major DE, Kesslak JP, Cotman CW, Finch CE, Day JR. PMID: 9390779.
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    234. Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain. Neuroscience. 1997 Aug; 79(4):973-82. Ulas J, Cotman CW. PMID: 9219960.
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    235. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci. 1997 Jul 15; 17(14):5316-26. Donovan FM, Pike CJ, Cotman CW, Cunningham DD. PMID: 9204916; PMCID: PMC6793831.
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    236. Adrenergic receptors in Alzheimer's disease brain: selective increases in the cerebella of aggressive patients. J Neurosci. 1997 Jul 15; 17(14):5573-80. Russo-Neustadt A, Cotman CW. PMID: 9204938; PMCID: PMC6793809.
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    237. Metabotropic glutamate receptor mGluR5 in astrocytes: pharmacological properties and agonist regulation. J Neurochem. 1997 Jul; 69(1):151-63. Balázs R, Miller S, Romano C, de Vries A, Chun Y, Cotman CW. PMID: 9202306.
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    238. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med. 1997 Apr 24; 336(17):1216-22. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS, Thal LJ. PMID: 9110909.
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    239. The beta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. A new principle in peptide function and the induction of neuropathology. Ann N Y Acad Sci. 1997 Apr 24; 814:1-16. Cotman CW. PMID: 9160955.
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    240. All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids. J Biol Chem. 1997 Mar 14; 272(11):7431-6. Cribbs DH, Pike CJ, Weinstein SL, Velazquez P, Cotman CW. PMID: 9054444.
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    241. Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation. Neurobiol Dis. 1997; 4(5):365-75. Su JH, Deng G, Cotman CW. PMID: 9440125.
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    242. Heparan sulfate potentiates the autocrine action of basic fibroblast growth factor in astrocytes: an in vivo and in vitro study. Neuroscience. 1997 Jan; 76(1):137-45. Gómez-Pinilla F, Miller S, Choi J, Cotman CW. PMID: 8971766.
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    243. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J Neuropathol Exp Neurol. 1997 Jan; 56(1):86-93. Su JH, Deng G, Cotman CW. PMID: 8990132.
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    244. Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex. Brain Res. 1996 Nov 25; 741(1-2):284-93. Nielson KA, Cummings BJ, Cotman CW. PMID: 9001734.
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    245. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 1996 Nov 11; 397(1):50-4. Deng G, Pike CJ, Cotman CW. PMID: 8941712.
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    246. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res. 1996 Nov 11; 739(1-2):79-87. Su JH, Cummings BJ, Cotman CW. PMID: 8955927.
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    247. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol Aging. 1996 Nov-Dec; 17(6):921-33. Cummings BJ, Pike CJ, Shankle R, Cotman CW. PMID: 9363804.
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    248. Cross-linking of concanavalin A receptors on cortical neurons induces programmed cell death. Neuroscience. 1996 Nov; 75(1):173-85. Cribbs DH, Kreng VM, Anderson AJ, Cotman CW. PMID: 8923532.
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    249. Attenuation of beta-amyloid neurotoxicity in vitro by potassium-induced depolarization. J Neurochem. 1996 Oct; 67(4):1774-7. Pike CJ, Balázs R, Cotman CW. PMID: 8858966.
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    250. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 1996 Oct; 6(4):493-506. Cotman CW, Su JH. PMID: 8944319.
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    251. Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. J Neurochem. 1996 Oct; 67(4):1435-47. Miller S, Sehati N, Romano C, Cotman CW. PMID: 8858925.
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    252. Gene expression of Alzheimer-associated presenilin-2 in the frontal cortex of Alzheimer and aged control brain. FEBS Lett. 1996 Sep 23; 394(1):17-20. Deng G, Su JH, Cotman CW. PMID: 8925918.
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    253. beta-Amyloid converts an acute phase injury response to chronic injury responses. Neurobiol Aging. 1996 Sep-Oct; 17(5):723-31. Cotman CW, Tenner AJ, Cummings BJ. PMID: 8892345.
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    254. Apolipoprotein-E genotyping of diabetic dementia patients: is diabetes rare in Alzheimer's disease? J Am Geriatr Soc. 1996 Aug; 44(8):897-904. Nielson KA, Nolan JH, Berchtold NC, Sandman CA, Mulnard RA, Cotman CW. PMID: 8708297.
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    255. Dopaminergic denervation of striatum results in elevated expression of NR2A subunit. Neuroreport. 1996 Jul 29; 7(11):1789-93. Ulas J, Cotman CW. PMID: 8905666.
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    256. Injury induces presenilin-1 gene expression in mouse brain. Neuroreport. 1996 Jul 29; 7(11):1773-6. Cribbs DH, Chen LS, Cotman CW, LaFerla FM. PMID: 8905662.
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    257. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 1996 Jul 08; 726(1-2):49-56. Neeper SA, Gómez-Pinilla F, Choi J, Cotman CW. PMID: 8836544.
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    258. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiol Aging. 1996 Jul-Aug; 17(4):653-9. Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. PMID: 8832640.
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    259. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem. 1996 Jul; 66(1):11-23. Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. PMID: 8661247.
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    260. beta-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes. Exp Neurol. 1996 May; 139(1):167-71. Pike CJ, Ramezan-Arab N, Miller S, Cotman CW. PMID: 8635563.
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    261. Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro. J Neurochem. 1996 Apr; 66(4):1374-82. Pike CJ, Vaughan PJ, Cunningham DD, Cotman CW. PMID: 8627288.
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    262. DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci. 1996 Mar 01; 16(5):1710-9. Anderson AJ, Su JH, Cotman CW. PMID: 8774439; PMCID: PMC6578676.
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    263. The canine as an animal model of human aging and dementia. Neurobiol Aging. 1996 Mar-Apr; 17(2):259-68. Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. PMID: 8744407.
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    264. Acquisition and long-term retention of a gross motor skill in Alzheimer's disease patients under constant and varied practice conditions. J Gerontol B Psychol Sci Soc Sci. 1996 Mar; 51(2):P103-11. Dick MB, Shankle RW, Beth RE, Dick-Muehlke C, Cotman CW, Kean ML. PMID: 8785686.
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    265. Localization and cell association of C1q in Alzheimer's disease brain. Exp Neurol. 1996 Mar; 138(1):22-32. Afagh A, Cummings BJ, Cribbs DH, Cotman CW, Tenner AJ. PMID: 8593893.
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    266. Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease. Neuroreport. 1996 Jan 31; 7(2):437-40. Su JH, Satou T, Anderson AJ, Cotman CW. PMID: 8730800.
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    267. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet. 1995 Dec 09; 346(8989):1524-8. Cummings BJ, Cotman CW. PMID: 7491048.
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    268. Acquisition and long-term retention of a fine motor skill in Alzheimer's disease. Brain Cogn. 1995 Dec; 29(3):294-306. Dick MB, Nielson KA, Beth RE, Shankle WR, Cotman CW. PMID: 8838387.
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    269. Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity. Brain Res. 1995 Oct 30; 697(1-2):35-43. Satou T, Cummings BJ, Cotman CW. PMID: 8593592.
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    270. Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate beta-amyloid(25-35) induced neurodegeneration in cultured hippocampal neurons. Brain Res. 1995 Oct 30; 697(1-2):53-62. Woods AG, Cribbs DH, Whittemore ER, Cotman CW. PMID: 8593595.
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    271. Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro. J Biol Chem. 1995 Oct 13; 270(41):23895-8. Pike CJ, Overman MJ, Cotman CW. PMID: 7592576.
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    272. Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. J Neurochem. 1995 Oct; 65(4):1487-98. Anderson AJ, Pike CJ, Cotman CW. PMID: 7561842.
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    273. Differentiation of serum-free mouse embryo cells into astrocytes is accompanied by induction of glutamine synthetase activity. J Neurosci Res. 1995 Oct 01; 42(2):184-91. Loo DT, Althoen MC, Cotman CW. PMID: 8568918.
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    274. Spatial learning and memory as a function of age in the dog. Behav Neurosci. 1995 Oct; 109(5):851-8. Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cotman CW, Ruehl WW, Milgram NW. PMID: 8554710.
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    275. Growth factor upregulation of a phosphoinositide-coupled metabotropic glutamate receptor in cortical astrocytes. J Neurosci. 1995 Sep; 15(9):6103-9. Miller S, Romano C, Cotman CW. PMID: 7666194; PMCID: PMC6577656.
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    276. Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia. Exp Neurol. 1995 Aug; 134(2):214-21. Korotzer AR, Watt J, Cribbs D, Tenner AJ, Burdick D, Glabe C, Cotman CW. PMID: 7556541.
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    277. A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. Neuroscience. 1995 Aug; 67(4):921-32. Whittemore ER, Loo DT, Watt JA, Cotman CW. PMID: 7675214.
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    278. Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J Neurochem. 1995 Aug; 65(2):931-4. Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Nostrand WE. PMID: 7616257.
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    279. Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci. 1995 Jul; 15(7 Pt 2):5389-401. Vaughan PJ, Pike CJ, Cotman CW, Cunningham DD. PMID: 7623161; PMCID: PMC6577903.
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    280. Decreases in protease nexins in Alzheimer's disease brain. Neurobiol Aging. 1995 Jul-Aug; 16(4):557-62. Choi BH, Kim RC, Vaughan PJ, Lau A, Van Nostrand WE, Cotman CW, Cunningham DD. PMID: 8544905.
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    281. Neural-network-based classification of cognitively normal, demented, Alzheimer disease and vascular dementia from single photon emission with computed tomography image data from brain. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5530-4. deFigueiredo RJ, Shankle WR, Maccato A, Dick MB, Mundkur P, Mena I, Cotman CW. PMID: 7777543; PMCID: PMC41729.
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    282. Differential effects of interleukin-1 beta and interleukin-2 on glia and hippocampal neurons in culture. Int J Dev Neurosci. 1995 Jun-Jul; 13(3-4):201-12. Araujo DM, Cotman CW. PMID: 7572276.
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    283. Possible coordinated gene expressions for FGF receptor, FGF-5, and FGF-2 following seizures. Exp Neurol. 1995 Jun; 133(2):164-74. Gómez-Pinilla F, van der Wal EA, Cotman CW. PMID: 7649223.
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    284. Roles of metabotropic glutamate receptors in brain plasticity and pathology. Ann N Y Acad Sci. 1995 May 10; 757:460-74. Miller S, Kesslak JP, Romano C, Cotman CW. PMID: 7611703.
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    285. Early association of reactive astrocytes with senile plaques in Alzheimer's disease. Exp Neurol. 1995 Apr; 132(2):172-9. Pike CJ, Cummings BJ, Cotman CW. PMID: 7789457.
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    286. Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat. Neurosci Lett. 1995 Mar 24; 188(2):117-20. Kesslak JP, Yuan D, Neeper S, Cotman CW. PMID: 7792054.
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    287. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neurosci. 1995 Mar; 15(3 Pt 1):2021-9. Gómez-Pinilla F, Vu L, Cotman CW. PMID: 7891149; PMCID: PMC6578134.
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    288. Color image analysis in neuroanatomical research: application to senile plaque subtype quantification in Alzheimer's disease. Neurobiol Aging. 1995 Mar-Apr; 16(2):211-23. Defigueiredo RJ, Cummings BJ, Mundkur PY, Cotman CW. PMID: 7777139.
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    289. Calretinin-immunoreactive neurons are resistant to beta-amyloid toxicity in vitro. Brain Res. 1995 Feb 13; 671(2):293-8. Pike CJ, Cotman CW. PMID: 7743217.
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    290. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol. 1995 Feb; 10(1):19-45. Cotman CW, Anderson AJ. PMID: 7598831.
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    291. Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia. Eur J Pharmacol. 1995 Jan 16; 288(2):125-30. Korotzer AR, Whittemore ER, Cotman CW. PMID: 7720773.
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    292. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. J Neurochem. 1995 Jan; 64(1):253-65. Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, Cotman CW. PMID: 7798921.
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    293. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Prog Brain Res. 1995; 106:217-25. Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ. PMID: 8584657.
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    294. Low-dose propranolol reduces aggression and agitation resembling that associated with orbitofrontal dysfunction in elderly demented patients. Alzheimer Dis Assoc Disord. 1995; 9(4):233-7. Shankle WR, Nielson KA, Cotman CW. PMID: 8749613.
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    295. Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease. Brain Res. 1994 Dec 30; 668(1-2):160-70. Vaughan PJ, Su J, Cotman CW, Cunningham DD. PMID: 7704602.
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    296. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport. 1994 Dec 20; 5(18):2529-33. Su JH, Anderson AJ, Cummings BJ, Cotman CW. PMID: 7696596.
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    297. Possible role of apoptosis in Alzheimer's disease. Ann N Y Acad Sci. 1994 Dec 15; 747:36-49. Cotman CW, Whittemore ER, Watt JA, Anderson AJ, Loo DT. PMID: 7847684.
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    298. Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. Neuroreport. 1994 Nov 21; 5(17):2358-62. Su JH, Cummings BJ, Cotman CW. PMID: 7533559.
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    299. Beta-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease. Neuroscience. 1994 Nov; 63(2):517-31. Pike CJ, Cummings BJ, Monzavi R, Cotman CW. PMID: 7891862.
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    300. Selective increase of NMDA-sensitive glutamate binding in the striatum of Parkinson's disease, Alzheimer's disease, and mixed Parkinson's disease/Alzheimer's disease patients: an autoradiographic study. J Neurosci. 1994 Nov; 14(11 Pt 1):6317-24. Ulas J, Weihmuller FB, Brunner LC, Joyce JN, Marshall JF, Cotman CW. PMID: 7965038; PMCID: PMC6577237.
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    301. Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res. 1994 Oct 24; 661(1-2):147-56. Watt JA, Pike CJ, Walencewicz-Wasserman AJ, Cotman CW. PMID: 7834365.
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    302. Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes. Eur J Pharmacol. 1994 Oct 14; 269(2):235-41. Miller S, Bridges RJ, Chamberlin AR, Cotman CW. PMID: 7851499.
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    303. Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state. Neurobiol Aging. 1994 Sep-Oct; 15(5):609-14. Smyth MD, Cribbs DH, Tenner AJ, Shankle WR, Dick M, Kesslak JP, Cotman CW. PMID: 7824052.
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    304. Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes. Neuroreport. 1994 Aug 15; 5(13):1585-8. Loo DT, Althoen MC, Cotman CW. PMID: 7529590.
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    305. Distribution of basic fibroblast growth factor in the developing rat brain. Neuroscience. 1994 Aug; 61(4):911-23. Gómez-Pinilla F, Lee JW, Cotman CW. PMID: 7838387.
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    306. Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons. Neuroreport. 1994 Jul 21; 5(12):1485-8. Whittemore ER, Loo DT, Cotman CW. PMID: 7948844.
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    307. A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine dicarboxylate. Neurosci Lett. 1994 Jun 20; 174(2):193-7. Bridges RJ, Lovering FE, Koch H, Cotman CW, Chamberlin AR. PMID: 7970177.
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    308. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol. 1994 May 15; 152(10):5050-9. Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. PMID: 8176223.
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    309. Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain. Neuroscience. 1994 May; 60(2):311-23. Van Der Wal EA, Gómez-Pinilla F, Cotman CW. PMID: 8072686.
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    310. Analysis of brain injury following intrahippocampal administration of beta-amyloid in streptozotocin-treated rats. Neurobiol Aging. 1994 Mar-Apr; 15(2):153-9. Smyth MD, Kesslak JP, Cummings BJ, Cotman CW. PMID: 7838285.
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    311. Subpopulations of dystrophic neurites [correction of neuritis] in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics. Brain Res. 1994 Feb 21; 637(1-2):37-44. Su JH, Cummings BJ, Cotman CW. PMID: 8180819.
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    312. Increased immunoreactivity for Jun- and Fos-related proteins in Alzheimer's disease: association with pathology. Exp Neurol. 1994 Feb; 125(2):286-95. Anderson AJ, Cummings BJ, Cotman CW. PMID: 8313943.
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    313. Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture. J Neurochem. 1994 Jan; 62(1):372-5. Weiss JH, Pike CJ, Cotman CW. PMID: 8263540.
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    314. Report of Alzheimer's disease Working Group A. Neurobiol Aging. 1994; 15 Suppl 2:S17-22. Cotman CW. PMID: 7700445.
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    315. Surface determinants of neuronal survival and growth on self-assembled monolayers in culture. Brain Res. 1993 Dec 10; 630(1-2):136-47. Stenger DA, Pike CJ, Hickman JJ, Cotman CW. PMID: 8118680.
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    316. Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease. Exp Neurol. 1993 Dec; 124(2):315-25. Cummings BJ, Su JH, Cotman CW. PMID: 8287930.
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    317. Synaptic reorganization in the hippocampus: an electrophysiological analysis. Ann N Y Acad Sci. 1993 Nov 17; 702:61-74. Kahle JS, Cotman CW. PMID: 8109878.
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    318. Beta-amyloid accumulation in aged canine brain: a model of early plaque formation in Alzheimer's disease. Neurobiol Aging. 1993 Nov-Dec; 14(6):547-60. Cummings BJ, Su JH, Cotman CW, White R, Russell MJ. PMID: 8295657.
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    319. Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates. Brain Res. 1993 Oct 29; 626(1-2):90-8. Wagner SL, Van Nostrand WE, Lau AL, Farrow JS, Suzuki M, Bartus RT, Schuppek R, Nguyen A, Cotman CW, Cunningham DD. PMID: 8281456.
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    320. Identification and distribution of axonal dystrophic neurites in Alzheimer's disease. Brain Res. 1993 Oct 22; 625(2):228-37. Su JH, Cummings BJ, Cotman CW. PMID: 8275305.
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    321. beta-Amyloid peptides induce degeneration of cultured rat microglia. Brain Res. 1993 Oct 08; 624(1-2):121-5. Korotzer AR, Pike CJ, Cotman CW. PMID: 8252383.
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    322. Carbachol increases intracellular free calcium in cultured rat microglia. Brain Res. 1993 Sep 03; 621(1):59-64. Whittemore ER, Korotzer AR, Etebari A, Cotman CW. PMID: 8106116.
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    323. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):7951-5. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. PMID: 8367446; PMCID: PMC47265.
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    324. Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid. Neuroscience. 1993 Sep; 56(2):269-74. Pike CJ, Cotman CW. PMID: 8247260.
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    325. Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. Neuroreport. 1993 Aug; 4(8):1049-51. Ulas J, Nguyen L, Cotman CW. PMID: 7902135.
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    326. Stimulation of phosphoinositide hydrolysis by trans-(+/-)-ACPD is greatly enhanced when astrocytes are cultured in a serum-free defined medium. Brain Res. 1993 Jul 30; 618(1):175-8. Miller S, Bridges RJ, Cotman CW. PMID: 8402173.
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    327. L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices. J Pharmacol Exp Ther. 1993 Jul; 266(1):207-15. Kahle JS, Cotman CW. PMID: 8101217.
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    328. Age-related changes in excitatory amino acid receptors in two mouse strains. Neurobiol Aging. 1993 May-Jun; 14(3):197-206. Magnusson KR, Cotman CW. PMID: 8391661.
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    329. Increased sensitivity to adenosine in the rat dentate gyrus molecular layer two weeks after partial entorhinal lesions. Brain Res. 1993 Apr 23; 609(1-2):201-10. Kahle JS, Ulas J, Cotman CW. PMID: 8508304.
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    330. Perineuronal satellitosis in the human hippocampal formation. Hippocampus. 1993 Apr; 3(2):239-50. Vijayan VK, Zhou SS, Russell MJ, Geddes J, Ellis W, Cotman CW. PMID: 8353607.
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    331. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci. 1993 Apr; 13(4):1676-87. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. PMID: 8463843; PMCID: PMC6576726.
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    332. Distribution of fibroblast growth factor 5 mRNA in the rat brain: an in situ hybridization study. Brain Res. 1993 Mar 19; 606(1):79-86. Gómez-Pinilla F, Cotman CW. PMID: 8462006.
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    333. Life span changes in the verbal categorization of odors. J Gerontol. 1993 Mar; 48(2):P49-53. Russell MJ, Cummings BJ, Profitt BF, Wysocki CJ, Gilbert AN, Cotman CW. PMID: 8473697.
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    334. Effects of aging on NMDA and MK801 binding sites in mice. Brain Res. 1993 Feb 26; 604(1-2):334-7. Magnusson KR, Cotman CW. PMID: 8457861.
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    335. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience. 1993 Feb; 52(4):843-54. Ulas J, Brunner LC, Nguyen L, Cotman CW. PMID: 8450977.
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    336. Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors. Brain Res. 1993 Jan 08; 600(1):49-55. Araujo DM, Cotman CW. PMID: 8422590.
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    337. Adenosine, L-AP4, and baclofen modulation of paired-pulse potentiation in the dentate gyrus: interstimulus interval-dependent pharmacology. Exp Brain Res. 1993; 94(1):97-104. Kahle JS, Cotman CW. PMID: 8392942.
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    338. Adaptive versus pathological plasticity. Possible contributions to age-related dementia. Adv Neurol. 1993; 59:35-45. Cotman CW, Pike CJ, Cummings BJ. PMID: 8420121.
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    339. Human brain tumor cyst fluid is mitogenic for primary astrocytes in culture. Neurosurgery. 1993 Jan; 32(1):95-8; discussion 98-9. Neal JH, Cotman CW. PMID: 8421562.
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    340. Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies. Neuroreport. 1993 Jan; 4(1):69-72. van der Wal EA, Gómez-Pinilla F, Cotman CW. PMID: 8453039.
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    341. Excitatory amino acid receptors in schizophrenia. Schizophr Bull. 1993; 19(1):105-17. Ulas J, Cotman CW. PMID: 8383875.
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    342. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience. 1992 Dec; 51(4):801-13. Su JH, Cummings BJ, Cotman CW. PMID: 1488123.
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    343. Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10857-61. Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegón M, Cotman C, Vaught JL, Neve RL. PMID: 1438289; PMCID: PMC50441.
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    344. Elevated NMDA receptors in parkinsonian striatum. Neuroreport. 1992 Nov; 3(11):977-80. Weihmuller FB, Ulas J, Nguyen L, Cotman CW, Marshall JF. PMID: 1482768.
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    345. bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy. Brain Res. 1992 Sep 25; 591(2):271-6. Cummings BJ, Yee GJ, Cotman CW. PMID: 1446240.
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    346. Gliotoxic actions of excitatory amino acids. Neuropharmacology. 1992 Sep; 31(9):899-907. Bridges RJ, Hatalski CG, Shim SN, Cummings BJ, Vijayan V, Kundi A, Cotman CW. PMID: 1436396.
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    347. beta-Amyloid neurotoxicity: a discussion of in vitro findings. Neurobiol Aging. 1992 Sep-Oct; 13(5):587-90. Cotman CW, Pike CJ, Copani A. PMID: 1461347.
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    348. beta-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. Neuroreport. 1992 Sep; 3(9):769-72. Pike CJ, Cummings BJ, Cotman CW. PMID: 1421135.
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    349. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience. 1992 Sep; 50(1):23-34. Geddes JW, Ulas J, Brunner LC, Choe W, Cotman CW. PMID: 1328933.
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    350. Programmed cell death: its possible contribution to neurotoxicity mediated by calcium channel antagonists. Brain Res. 1992 Aug 07; 587(2):233-40. Koh JY, Cotman CW. PMID: 1525659.
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    351. Transient lesion-induced increase of basic fibroblast growth factor and its receptor in layer VIb (subplate cells) of the adult rat cerebral cortex. Neuroscience. 1992 Aug; 49(4):771-80. Gómez-Pinilla F, Cotman CW. PMID: 1436480.
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    352. Adrenal hormone effects on hippocampal excitatory amino acid binding. Brain Res. 1992 Jul 10; 585(1-2):161-8. Clark AS, Cotman CW. PMID: 1355001.
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    353. N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease. Neuroscience. 1992 Jul; 49(1):45-61. Ulas J, Brunner LC, Geddes JW, Choe W, Cotman CW. PMID: 1407551.
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    354. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 1992 Jun; 48(4):763-77. Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW. PMID: 1378573.
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    355. 1-Aminocyclopentane-trans-1,3-dicarboxylic acid induces glutamine synthetase activity in cultured astrocytes. J Neurochem. 1992 May; 58(5):1967-70. Miller S, Cotman CW, Bridges RJ. PMID: 1348527.
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    356. Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors. J Neurosci. 1992 May; 12(5):1668-78. Araujo DM, Cotman CW. PMID: 1578261; PMCID: PMC6575893.
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    357. In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: relationship to performance on the Morris water maze. Behav Neurosci. 1992 Apr; 106(2):324-35. Clark AS, Magnusson KR, Cotman CW. PMID: 1317185.
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    358. Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2551-5. Van Nostrand WE, Wagner SL, Shankle WR, Farrow JS, Dick M, Rozemuller JM, Kuiper MA, Wolters EC, Zimmerman J, Cotman CW, et al. PMID: 1557359; PMCID: PMC48699.
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    359. Lesions of the rat postsubiculum impair performance on spatial tasks. Behav Neural Biol. 1992 Mar; 57(2):131-43. Taube JS, Kesslak JP, Cotman CW. PMID: 1586352.
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    360. Alterations in [3H]kainate and N-methyl-D-aspartate-sensitive L-[3H]-glutamate binding in the rat hippocampal formation following fimbria-fornix lesions. Exp Neurol. 1992 Feb; 115(2):271-81. Geddes JW, Brunner L, Cotman CW, Buzsáki G. PMID: 1310474.
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    361. Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A. Brain Res Bull. 1992 Feb; 28(2):219-26. Emerich DF, Black BA, Kesslak JP, Cotman CW, Walsh TJ. PMID: 1596741.
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    362. Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res. 1992 Jan 08; 569(1):141-5. Araujo DM, Cotman CW. PMID: 1611474.
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    363. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem. 1992 Jan 05; 267(1):546-54. Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C. PMID: 1730616.
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    364. Voltage-gated currents expressed by rat microglia in culture. Glia. 1992; 6(2):81-8. Korotzer AR, Cotman CW. PMID: 1328052.
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    365. An overview and perspective on the potential relevance of neuronal growth to the development of epilepsy and epilepsy-related disturbances. Epilepsy Res Suppl. 1992; 9:257-61; discussion 261-4. Cotman CW. PMID: 1285909.
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    366. Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection. J Neurosci. 1992 Jan; 12(1):345-55. Gómez-Pinilla F, Lee JW, Cotman CW. PMID: 1309575; PMCID: PMC6575703.
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    367. Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation. Neuroreport. 1991 Dec; 2(12):763-5. Copani A, Koh JY, Cotman CW. PMID: 1793819.
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    368. The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10302-6. Van Nostrand WE, Farrow JS, Wagner SL, Bhasin R, Goldgaber D, Cotman CW, Cunningham DD. PMID: 1946448; PMCID: PMC52916.
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    369. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 1991 Nov 01; 563(1-2):311-4. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. PMID: 1786545.
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    370. Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9431-5. Koh JY, Palmer E, Cotman CW. PMID: 1658782; PMCID: PMC52731.
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    371. Increased density of excitatory amino acid transport sites in the hippocampal formation following an entorhinal lesion. Brain Res. 1991 Oct 25; 562(2):285-90. Anderson KJ, Bridges RJ, Cotman CW. PMID: 1685344.
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    372. A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture. Brain Res. 1991 Oct 11; 561(2):338-43. Koh JY, Palmer E, Lin A, Cotman CW. PMID: 1666330.
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    373. Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controls. Preliminary studies. Arch Gen Psychiatry. 1991 Sep; 48(9):840-7. Buchsbaum MS, Kesslak JP, Lynch G, Chui H, Wu J, Sicotte N, Hazlett E, Teng E, Cotman CW. PMID: 1929775.
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    374. Long-term potentiation of excitatory and slow inhibitory synaptic potentials in the hippocampal-septal projection of the rat. Brain Res. 1991 Aug 30; 558(1):120-2. Stevens DR, Cotman CW. PMID: 1657309.
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    375. Effects of tetrahydroaminoacridine (THA) on functional recovery after sequential lesion of the entorhinal cortex. Brain Res. 1991 Aug 23; 557(1-2):57-63. Kesslak JP, Korotzer A, Song A, Kamali K, Cotman CW. PMID: 1747769.
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    376. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol. 1991 Aug 14; 207(4):367-8. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. PMID: 1783006.
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    377. Agonists selective for phosphoinositide-coupled receptors sensitize neurons to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4). Brain Res. 1991 Aug 02; 555(2):215-9. Whittemore ER, Cotman CW. PMID: 1681998.
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    378. Plasticity in Alzheimer's disease: too much or not enough? Neurobiol Aging. 1991 Jul-Aug; 12(4):330-3; discussion 352-5. Geddes JW, Cotman CW. PMID: 1961362.
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    379. Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation. Exp Neurol. 1991 Apr; 112(1):72-8. Vijayan VK, Geddes JW, Anderson KJ, Chang-Chui H, Ellis WG, Cotman CW. PMID: 2013308.
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    380. Olfactory classical conditioning in neonates. Pediatrics. 1991 Apr; 87(4):511-8. Sullivan RM, Taborsky-Barba S, Mendoza R, Itano A, Leon M, Cotman CW, Payne TF, Lott I. PMID: 2011429; PMCID: PMC1952659.
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    381. Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J Med Chem. 1991 Feb; 34(2):717-25. Bridges RJ, Stanley MS, Anderson MW, Cotman CW, Chamberlin AR. PMID: 1671706.
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    382. Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione. Eur J Pharmacol. 1991 Jan 03; 192(1):199-200. Bridges RJ, Koh JY, Hatalski CG, Cotman CW. PMID: 1674918.
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    383. Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors. Neurosci Lett. 1991 Jan 02; 121(1-2):239-43. Peterson C, Vanderklish P, Seubert P, Cotman C, Lynch G. PMID: 2020380.
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    384. Basic fibroblast growth factor in the mature brain and its possible role in Alzheimer's disease. Ann N Y Acad Sci. 1991; 638:221-31. Cotman CW, Gómez-Pinilla F. PMID: 1785803.
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    385. Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease. Neurology. 1991 Jan; 41(1):51-4. Kesslak JP, Nalcioglu O, Cotman CW. PMID: 1985296.
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    386. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 1990 Nov 19; 533(2):315-20. Koh JY, Yang LL, Cotman CW. PMID: 2289145.
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    387. Induction of basic fibroblast growth factor in Alzheimer's disease pathology. Neuroreport. 1990 Nov-Dec; 1(3-4):211-4. Gómez-Pinilla F, Cummings BJ, Cotman CW. PMID: 1717039.
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    388. Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis. J Neurochem. 1990 Aug; 55(2):386-90. Peterson C, Giguere JF, Cotman CW, Butterworth RF. PMID: 1973453.
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    389. Kainate receptors in the rat hippocampus: a distribution and time course of changes in response to unilateral lesions of the entorhinal cortex. J Neurosci. 1990 Jul; 10(7):2352-62. Ulas J, Monaghan DT, Cotman CW. PMID: 2165522; PMCID: PMC6570393.
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    390. Peripheral administration of a long-chain fatty alcohol promotes septal cholinergic neurons survival after fimbria-fornix transection. Brain Res. 1990 Jun 04; 518(1-2):295-8. Borg J, Kesslak PJ, Cotman CW. PMID: 2390721.
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    391. Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy. Exp Neurol. 1990 Jun; 108(3):214-20. Geddes JW, Cahan LD, Cooper SM, Kim RC, Choi BH, Cotman CW. PMID: 2161774.
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    392. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain Res. 1990 May 07; 515(1-2):39-44. Peterson C, Cotman CW. PMID: 2357575.
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    393. Regional distribution of alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding sites in rat brain: effect of chemical modification of SH- groups in tissue sections. J Neurochem. 1990 May; 54(5):1682-8. Baudry M, Monaghan D, Cotman C, Altar CA. PMID: 2157815.
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    394. Long-term survival of neural transplants to senescence in rats. Exp Neurol. 1990 May; 108(2):105-8. Russell MJ, Vijayan VK, Gibbs RB, Geddes JW, Jacobson CH, Cotman CW. PMID: 2335191.
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    395. Beta-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci Lett. 1990 Mar 14; 110(3):319-24. Whitson JS, Glabe CG, Shintani E, Abcar A, Cotman CW. PMID: 2183090.
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    396. Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease. Neurosci Lett. 1990 Feb 05; 109(1-2):54-61. Geddes JW, Wong J, Choi BH, Kim RC, Cotman CW, Miller FD. PMID: 2314641.
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    397. Increased spectrin proteolysis in the brindled mouse brain. Neurosci Lett. 1990 Jan 22; 108(3):303-8. Seubert P, Peterson C, Vanderklish P, Cotman C, Lynch G. PMID: 2304649.
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    398. Plastic response of hippocampal excitatory amino acid receptors to deafferentation and reinnervation. Neuroscience. 1990; 34(1):9-17. Ulas J, Monaghan DT, Cotman CW. PMID: 2158009.
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    399. Excitotoxic amino acid receptors in human complex partial epilepsy. Stereotact Funct Neurosurg. 1990; 54-55:21-4. Cahan LD, Geddes JW, Choi BH, Cotman C. PMID: 1964242.
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    400. Plasticity of excitatory amino acid receptors: implications for aging and Alzheimer's disease. Prog Brain Res. 1990; 86:55-61. Cotman CW, Geddes JW, Ulas J, Klein M. PMID: 1965056.
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    401. Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms? Prog Brain Res. 1990; 83:427-34. Cotman CW, Geddes JW, Kahle JS. PMID: 2203106.
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    402. Molecular markers of reactive plasticity. Adv Exp Med Biol. 1990; 268:425-32. Geddes JW, Wilson MC, Miller FD, Cotman CW. PMID: 2075860.
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    403. Changes in excitatory amino acid modulation of phosphoinositide metabolism during development. Brain Res Dev Brain Res. 1990 Jan 01; 51(1):132-4. Palmer E, Nangel-Taylor K, Krause JD, Roxas A, Cotman CW. PMID: 2153480.
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    404. Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker. Neuroscience. 1990; 38(2):515-25. Geddes JW, Hess EJ, Hart RA, Kesslak JP, Cotman CW, Wilson MC. PMID: 1702194.
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    405. Autoradiographic characterization of putative excitatory amino acid transport sites. Neuroscience. 1990; 38(2):311-22. Anderson KJ, Monaghan DT, Bridges RJ, Tavoularis AL, Cotman CW. PMID: 1979852.
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    406. The neurobiology of learning and memory. Cognition. 1989 Nov; 33(1-2):201-41. Cotman CW, Lynch GS. PMID: 2691183.
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    407. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8284-8. Wagner SL, Geddes JW, Cotman CW, Lau AL, Gurwitz D, Isackson PJ, Cunningham DD. PMID: 2813392; PMCID: PMC298265.
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    408. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature. 1989 Oct 12; 341(6242):546-9. Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD. PMID: 2507928.
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    409. Strain-dependent decrease in glutamate binding to the N-methyl-D-aspartic acid receptor during aging. Neurosci Lett. 1989 Oct 09; 104(3):309-13. Peterson C, Cotman CW. PMID: 2573018.
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    410. N-methyl-D-aspartate receptors and Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):603-5; discussion 618-20. Cotman CW, Geddes JW, Bridges RJ, Monaghan DT. PMID: 2572983.
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    411. Plasticity, pathology, and Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):571-3; discussion 588-90. Geddes JW, Cotman CW. PMID: 2812229.
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    412. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res. 1989 Aug 07; 494(1):65-74. Brewer GJ, Cotman CW. PMID: 2765923.
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    413. Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor. Eur J Pharmacol. 1989 Aug 03; 166(3):585-7. Palmer E, Monaghan DT, Cotman CW. PMID: 2553440.
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    414. Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons. Brain Res Dev Brain Res. 1989 Aug 01; 48(2):187-95. Peterson C, Neal JH, Cotman CW. PMID: 2673575.
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    415. Regulation of muscarinic receptors in hippocampus following cholinergic denervation and reinnervation by septal and striatal transplants. J Neurosci. 1989 Aug; 9(8):2776-91. Joyce JN, Gibbs RB, Cotman CW, Marshall JF. PMID: 2769366; PMCID: PMC6569685.
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    416. N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization. Neurosci Lett. 1989 Jul 03; 101(3):241-6. Balázs R, Hack N, Jørgensen OS, Cotman CW. PMID: 2549463.
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    417. Structure-function studies on N-oxalyl-diamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP is a selective non-NMDA agonist. J Neurosci. 1989 Jun; 9(6):2073-9. Bridges RJ, Stevens DR, Kahle JS, Nunn PB, Kadri M, Cotman CW. PMID: 2542485; PMCID: PMC6569742.
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    418. NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons. Neurosci Lett. 1989 May 08; 99(3):268-73. Brewer GJ, Cotman CW. PMID: 2566963.
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    419. Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury. Exp Neurol. 1989 May; 104(2):118-24. Gómez-Pinilla F, Tram H, Cotman CW, Nieto-Sampedro M. PMID: 2651138.
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    420. Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science. 1989 Mar 17; 243(4897):1488-90. Whitson JS, Selkoe DJ, Cotman CW. PMID: 2928783.
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    421. Carbachol depresses synaptic responses in the medial but not the lateral perforant path. Brain Res. 1989 Mar 13; 482(1):159-63. Kahle JS, Cotman CW. PMID: 2706473.
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    422. Dynamic changes of excitatory amino acid receptors in the rat hippocampus following transient cerebral ischemia. J Neurosci. 1989 Mar; 9(3):798-805. Westerberg E, Monaghan DT, Kalimo H, Cotman CW, Wieloch TW. PMID: 2538582; PMCID: PMC6569965.
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    423. NGF receptor immunoreactivity in aged rat brain. Brain Res. 1989 Feb 13; 479(2):255-62. Gómez-Pinilla F, Cotman CW, Nieto-Sampedro M. PMID: 2538208.
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    424. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol. 1989; 29:365-402. Monaghan DT, Bridges RJ, Cotman CW. PMID: 2543272.
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    425. Multiple excitatory amino acid receptor regulation of intracellular Ca2+. Implications for aging and Alzheimer's disease. Ann N Y Acad Sci. 1989; 568:138-48. Cotman C, Monaghan D. PMID: 2560895.
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    426. N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio). Neuroscience. 1989; 32(1):39-47. Geddes JW, Cooper SM, Cotman CW, Patel S, Meldrum BS. PMID: 2573860.
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    427. Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9836-40. Monaghan DT, Olverman HJ, Nguyen L, Watkins JC, Cotman CW. PMID: 2904680; PMCID: PMC282876.
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    428. Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation. Brain Res. 1988 Sep; 464(2):161-5. Palmer E, Monaghan DT, Cotman CW. PMID: 2905924.
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    429. Olfactory tests as possible probes for detecting and monitoring Alzheimer's disease. Neurobiol Aging. 1988 Jul-Aug; 9(4):399-403. Kesslak JP, Cotman CW, Chui HC, Van den Noort S, Fang H, Pfeffer R, Lynch G. PMID: 3185859.
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    430. Hippocampal but not astrocyte transplants enhance recovery on a forced choice alternation task after kainate lesions. Brain Res. 1988 Jun 28; 454(1-2):347-54. Kesslak JP, Walencewicz A, Calin L, Nieto-Sampedro M, Cotman CW. PMID: 3409018.
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    431. The binding of a monoclonal antibody reactive with pp60v-src to the rat CNS both in vitro and in vivo: evidence that the epitope is present intracellularly as well as being associated with a number of antigenically related polypeptides located externally in the plasma membrane only in the synaptic region. Brain Res. 1988 Jun 14; 452(1-2):184-202. Lasher RS, Erickson PF, Mena EE, Cotman CW. PMID: 2456825.
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    432. Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury. Neurosci Lett. 1988 Apr 12; 86(3):361-5. Nieto-Sampedro M, Lim R, Hicklin DJ, Cotman CW. PMID: 3380328.
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    433. Transmitter phenotype is a major determinant in the specificity of synapses formed by cholinergic neurons transplanted to the hippocampus. Neuroscience. 1988 Apr; 25(1):19-25. Anderson KJ, Gibbs RB, Cotman CW. PMID: 2899304.
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    434. NMDA receptor activation and early olfactory learning. Brain Res. 1988 Apr 01; 467(2):309-12. Lincoln J, Coopersmith R, Harris EW, Cotman CW, Leon M. PMID: 2897868.
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    435. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo. Nature. 1988 Mar 24; 332(6162):360-1. Anderson KJ, Dam D, Lee S, Cotman CW. PMID: 3352734.
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    436. Cooperation between nerve growth factor and laminin or fibronectin in promoting sensory neuron survival and neurite outgrowth. Brain Res. 1988 Feb 01; 466(2):219-28. Millaruelo AI, Nieto-Sampedro M, Cotman CW. PMID: 3359313.
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    437. Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. Eur J Pharmacol. 1988 Jan 19; 145(3):357-9. Bridges RJ, Kadri MM, Monaghan DT, Nunn PB, Watkins JC, Cotman CW. PMID: 2895006.
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    438. Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. Annu Rev Neurosci. 1988; 11:61-80. Cotman CW, Monaghan DT, Ganong AH. PMID: 2452598.
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    439. Regulation of acetylcholine muscarinic receptors by embryonic septal grafts showing cholinergic innervation of host hippocampus. Prog Brain Res. 1988; 78:109-16. Joyce JN, Gibbs RB, Cotman CW, Marshall JF. PMID: 3247416.
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    440. Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease. Adv Neurol. 1988; 47:313-35. Cotman CW, Anderson KJ. PMID: 3278521.
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    441. The role of trophic factors in behavioral recovery and integration of transplants. Prog Brain Res. 1988; 78:311-9. Cotman CW, Kesslak JP. PMID: 3073414.
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    442. NGF receptor immunoreactivity in rat brain: topographic distribution and response to entorhinal ablation. Neurosci Lett. 1987 Dec 04; 82(3):260-6. Gomez-Pinilla F, Cotman CW, Nieto-Sampedro M. PMID: 2827075.
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    443. Entorhinal transplants and spatial memory abilities in rats. Behav Brain Res. 1987 Oct; 26(1):29-35. Gibbs RB, Yu J, Cotman CW. PMID: 3675832.
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    444. Long-term support by injured brain extract of a subpopulation of ciliary ganglion neurons purified by differential adhesion. Neurochem Res. 1987 Oct; 12(10):901-7. Needels DL, Nieto-Sampedro M, Cotman CW. PMID: 3683740.
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    445. Excitatory actions of tetrahydro-9-aminoacridine (THA) on hippocampal pyramidal neurons. Neurosci Lett. 1987 Aug 31; 79(3):301-5. Stevens DR, Cotman CW. PMID: 3658222.
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    446. Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site. Brain Res. 1987 Aug 25; 418(2):361-5. Harris EW, Stevens DR, Cotman CW. PMID: 2890405.
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    447. Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-I. Brain Res. 1987 Jul 07; 415(1):40-8. Rosenblatt DE, Cotman CW, Nieto-Sampedro M, Rowe JW, Knauer DJ. PMID: 3040175.
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    448. A L-[3H]glutamate binding site on glia: an autoradiographic study on implanted astrocytes. Brain Res. 1987 Jul 07; 415(1):163-8. Bridges RJ, Kesslak JP, Nieto-Sampedro M, Broderick JT, Yu J, Cotman CW. PMID: 2887242.
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    449. A novel chloride-dependent L-[3H]glutamate binding site in astrocyte membranes. J Neurochem. 1987 Jun; 48(6):1709-15. Bridges RJ, Nieto-Sampedro M, Kadri M, Cotman CW. PMID: 2883255.
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    450. Factors affecting survival and outgrowth from transplants of entorhinal cortex. Neuroscience. 1987 Jun; 21(3):699-706. Gibbs RB, Cotman CW. PMID: 3627432.
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    451. N-acetylaspartylglutamate identified in the rat retinal ganglion cells and their projections in the brain. Brain Res. 1987 May 12; 411(1):172-7. Anderson KJ, Borja MA, Cotman CW, Moffett JR, Namboodiri MA, Neale JH. PMID: 3300843.
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    452. Hydrocortisone administration alters glial reaction to entorhinal lesion in the rat dentate gyrus. Exp Neurol. 1987 May; 96(2):307-20. Vijayan VK, Cotman CW. PMID: 3569457.
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