Charles L Limoli

Title(s)Professor, Radiation Oncology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3053
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    Collapse Research 
    Collapse Research Activities and Funding
    Improving pediatric brain tumor treatments using FLASH radiotherapy
    NIH R01CA254892Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Increasing the therapeutic index of brain tumor treatment through innovative FLASH radiotherapy
    NIH P01CA244091Jun 1, 2020 - May 31, 2025
    Role: Principal Investigator
    2016 Annual Meeting of the Radiation Research Society
    NIH R13CA206197Apr 15, 2016 - Mar 31, 2017
    Role: Principal Investigator
    Mechanisms underlying radiation-and chemotherapy induced cognitive impairment.
    NIH R01NS089575Jan 1, 2016 - Dec 31, 2021
    Role: Principal Investigator
    Translational strategies for protecting the brain against radio- and chemotherapy
    NIH R01NS074388Jan 15, 2011 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Radiomics approach for identifying radiation-induced normal tissue toxicity in the lung. Res Sq. 2024 Feb 23. Drayson OG, Gruel PM, Limoli CL. PMID: 38464210; PMCID: PMC10925422.
      View in: PubMed   Mentions:
    2. Acute hypoxia does not alter tumor sensitivity to FLASH radiotherapy. Int J Radiat Oncol Biol Phys. 2024 Feb 20. Leavitt RJ, Almeida A, Grilj V, Montay-Gruel P, Godfroid C, Petit B, Bailat C, Limoli CL, Vozenin MC. PMID: 38387809.
      View in: PubMed   Mentions:    Fields:    
    3. More May Not be Better: Enhanced Spacecraft Shielding May Exacerbate Cognitive Decrements by Increasing Pion Exposures during Deep Space Exploration. Radiat Res. 2024 Feb 01; 201(2):93-103. Vozenin MC, Alaghband Y, Drayson OGG, Piaget F, Leavitt R, Allen BD, Doan NL, Rostomyan T, Stabilini A, Reggiani D, Hajdas W, Yukihara EG, Norbury JW, Bailat C, Desorgher L, Baulch JE, Limoli CL. PMID: 38171489.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Complex 33-beam simulated galactic cosmic radiation exposure impacts cognitive function and prefrontal cortex neurotransmitter networks in male mice. Nat Commun. 2023 Nov 27; 14(1):7779. Desai RI, Kangas BD, Luc OT, Solakidou E, Smith EC, Dawes MH, Ma X, Makriyannis A, Chatterjee S, Dayeh MA, Muñoz-Jaramillo A, Desai MI, Limoli CL. PMID: 38012180; PMCID: PMC10682413.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    5. Antitumor Effect by Either FLASH or Conventional Dose Rate Irradiation Involves Equivalent Immune Responses. Int J Radiat Oncol Biol Phys. 2024 Mar 15; 118(4):1110-1122. Almeida A, Godfroid C, Leavitt RJ, Montay-Gruel P, Petit B, Romero J, Ollivier J, Meziani L, Sprengers K, Paisley R, Grilj V, Limoli CL, Romero P, Vozenin MC. PMID: 37951550.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Dosimetry of the PIM1 Pion Beam at the Paul Scherrer Institute for Radiobiological Studies of Mice. Radiat Res. 2023 10 01; 200(4):357-365. Desorgher L, Stabilini A, Rostomyan T, Reggiani D, Hajdas W, Marcinkowski RM, Vozenin MC, Limoli CL, Yukihara EG, Bailat C. PMID: 37702413.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates. Radiother Oncol. 2023 Nov; 188:109906. Barghouth PG, Melemenidis S, Montay-Gruel P, Ollivier J, Viswanathan V, Jorge PG, Soto LA, Lau BC, Sadeghi C, Edlabadkar A, Zhang R, Ru N, Baulch JE, Manjappa R, Wang J, Le Bouteiller M, Surucu M, Yu A, Bush K, Skinner L, Maxim PG, Loo BW, Limoli CL, Vozenin MC, Frock RL. PMID: 37690668; PMCID: PMC10591966.
      View in: PubMed   Mentions: 1     Fields:    
    8. The Correlation Between Lymphocyte Nadir and Radiation Therapy for Soft Tissue Sarcoma: Defining Key Dosimetric Parameters and Outlining Clinical Significance. Adv Radiat Oncol. 2024 Jan; 9(1):101309. Ku E, Harada G, Chiao E, Rao P, Hosseinian S, Seyedin S, Healy E, Maxim P, Chow W, Stitzlein R, Limoli C, Harris J. PMID: 38260229; PMCID: PMC10801664.
      View in: PubMed   Mentions:
    9. The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation. Radiother Oncol. 2023 09; 186:109767. Limoli CL, Kramár EA, Almeida A, Petit B, Grilj V, Baulch JE, Ballesteros-Zebadua P, Loo BW, Wood MA, Vozenin MC. PMID: 37385377.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. New Radiobiological Principles for the CNS Arising from Space Radiation Research. Life (Basel). 2023 May 31; 13(6). Britten RA, Limoli CL. PMID: 37374076; PMCID: PMC10303969.
      View in: PubMed   Mentions:
    11. Towards quantitative in vivo dosimetry using x-ray acoustic computed tomography. Med Phys. 2023 Nov; 50(11):6894-6907. Sun L, Gonzalez G, Pandey PK, Wang S, Kim K, Limoli C, Chen Y, Xiang L. PMID: 37203253; PMCID: PMC10656364.
      View in: PubMed   Mentions: 1     Fields:    
    12. Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy. Neuro Oncol. 2023 05 04; 25(5):927-939. Allen BD, Alaghband Y, Kramár EA, Ru N, Petit B, Grilj V, Petronek MS, Pulliam CF, Kim RY, Doan NL, Baulch JE, Wood MA, Bailat C, Spitz DR, Vozenin MC, Limoli CL. PMID: 36334265; PMCID: PMC10158064.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy. Cancer Res Commun. 2023 04; 3(4):725-737. Alaghband Y, Allen BD, Kramár EA, Zhang R, Drayson OGG, Ru N, Petit B, Almeida A, Doan NL, Wood MA, Baulch JE, Ballesteros-Zebadua P, Vozenin MC, Limoli CL. PMID: 37377749; PMCID: PMC10135433.
      View in: PubMed   Mentions: 1  Translation:Animals
    14. FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates. bioRxiv. 2023 Mar 27. Barghouth PG, Melemenidis S, Montay-Gruel P, Ollivier J, Viswanathan V, Jorge PG, Soto LA, Lau BC, Sadeghi C, Edlabadkar A, Manjappa R, Wang J, Le Bouteiller M, Surucu M, Yu A, Bush K, Skinner L, Maxim PG, Loo BW, Limoli CL, Vozenin MC, Frock RL. PMID: 37034651; PMCID: PMC10081175.
      View in: PubMed   Mentions:
    15. A rigorous behavioral testing platform for the assessment of radiation-induced neurological outcomes. Methods Cell Biol. 2023; 180:177-197. Drayson OGG, Vozenin MC, Limoli CL. PMID: 37890929.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments. Cell Mol Life Sci. 2023 Jan 06; 80(1):29. Alaghband Y, Klein PM, Kramár EA, Cranston MN, Perry BC, Shelerud LM, Kane AE, Doan NL, Ru N, Acharya MM, Wood MA, Sinclair DA, Dickstein DL, Soltesz I, Limoli CL, Baulch JE. PMID: 36607431; PMCID: PMC9823026.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs. Clin Cancer Res. 2022 09 01; 28(17):3814-3823. Rohrer Bley C, Wolf F, Gonçalves Jorge P, Grilj V, Petridis I, Petit B, Böhlen TT, Moeckli R, Limoli C, Bourhis J, Meier V, Vozenin MC. PMID: 35421221.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    18. Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams to support multicenter FLASH preclinical studies. Radiother Oncol. 2022 10; 175:203-209. Jorge PG, Melemenidis S, Grilj V, Buchillier T, Manjappa R, Viswanathan V, Gondré M, Vozenin MC, Germond JF, Bochud F, Moeckli R, Limoli C, Skinner L, No HJ, Wu YF, Surucu M, Yu AS, Lau B, Wang J, Schüler E, Bush K, Graves EE, Maxim PG, Loo BW, Bailat C. PMID: 36030934.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Sex Differences in Taxane Toxicities. Cancers (Basel). 2022 Jul 08; 14(14). Chmielewski NN, Limoli CL. PMID: 35884386; PMCID: PMC9317669.
      View in: PubMed   Mentions: 1  
    20. Impact of spaceflight stressors on behavior and cognition: A molecular, neurochemical, and neurobiological perspective. Neurosci Biobehav Rev. 2022 07; 138:104676. Desai RI, Limoli CL, Stark CEL, Stark SM. PMID: 35461987.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Dissecting Differential Complex Behavioral Responses to Simulated Space Radiation Exposures. Radiat Res. 2022 03 01; 197(3):289-297. Britten RA, Fesshaye A, Ihle P, Wheeler A, Baulch JE, Limoli CL, Stark CE. PMID: 34905619.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    22. An International Consensus on the Design of Prospective Clinical-Translational Trials in Spatially Fractionated Radiation Therapy. Adv Radiat Oncol. 2022 Mar-Apr; 7(2):100866. Mayr NA, Snider JW, Regine WF, Mohiuddin M, Hippe DS, Peñagarícano J, Mohiuddin M, Kudrimoti MR, Zhang H, Limoli CL, Le QT, Simone CB. PMID: 35198833; PMCID: PMC8843999.
      View in: PubMed   Mentions: 6  
    23. Breaking barriers: Neurodegenerative repercussions of radiotherapy induced damage on the blood-brain and blood-tumor barrier. Free Radic Biol Med. 2022 01; 178:189-201. Allen BD, Limoli CL. PMID: 34875340; PMCID: PMC8925982.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    24. Differential organization of open field behavior in mice following acute or chronic simulated GCR exposure. Behav Brain Res. 2022 01 07; 416:113577. Schaeffer EA, Blackwell AA, Oltmanns JRO, Einhaus R, Lake R, Hein CP, Baulch JE, Limoli CL, Ton ST, Kartje GL, Wallace DG. PMID: 34506841.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    25. Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function. Int J Mol Sci. 2021 Aug 21; 22(16). Klein PM, Alaghband Y, Doan NL, Ru N, Drayson OGG, Baulch JE, Kramár EA, Wood MA, Soltesz I, Limoli CL. PMID: 34445726; PMCID: PMC8396607.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Model studies of the role of oxygen in the FLASH effect. Med Phys. 2022 Mar; 49(3):2068-2081. Favaudon V, Labarbe R, Limoli CL. PMID: 34407219; PMCID: PMC8854455.
      View in: PubMed   Mentions: 22     Fields:    
    27. Sex-Specific Differences in Toxicity Following Systemic Paclitaxel Treatment and Localized Cardiac Radiotherapy. Cancers (Basel). 2021 Aug 06; 13(16). Chmielewski-Stivers N, Petit B, Ollivier J, Monceau V, Tsoutsou P, Quintela Pousa A, Lin X, Limoli C, Vozenin MC. PMID: 34439129; PMCID: PMC8394799.
      View in: PubMed   Mentions: 3  
    28. The Cannabinoid Receptor 1 Reverse Agonist AM251 Ameliorates Radiation-Induced Cognitive Decrements. Front Cell Neurosci. 2021; 15:668286. Parihar VK, Syage A, Flores L, Lilagan A, Allen BD, Angulo MC, Song J, Smith SM, Arechavala RJ, Giedzinski E, Limoli CL. PMID: 34262437; PMCID: PMC8273551.
      View in: PubMed   Mentions: 3  
    29. Extracellular Vesicle Proteome of Breast Cancer Patients with and Without Cognitive Impairment Following Anthracycline-based Chemotherapy: An Exploratory Study. Biomark Insights. 2021; 16:11772719211018204. Koh YQ, Ng DQ, Ng CC, Boey A, Wei M, Sze SK, Ho HK, Acharya M, Limoli CL, Chan A. PMID: 34103887; PMCID: PMC8150437.
      View in: PubMed   Mentions: 4  
    30. Letter in Response to Doyen et al., "Early Toxicities After High Dose Rate Proton Therapy in Cancer Treatments". Front Oncol. 2021; 11:687593. Montay-Gruel P, Vozenin MC, Limoli CL. PMID: 34055651; PMCID: PMC8155667.
      View in: PubMed   Mentions:
    31. Nonhuman primate models in the study of spaceflight stressors: Past contributions and future directions. Life Sci Space Res (Amst). 2021 Aug; 30:9-23. Desai RI, Kangas BD, Limoli CL. PMID: 34281669.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    32. Chronic Low Dose Neutron Exposure Results in Altered Neurotransmission Properties of the Hippocampus-Prefrontal Cortex Axis in Both Mice and Rats. Int J Mol Sci. 2021 Apr 01; 22(7). Krishnan B, Natarajan C, Bourne KZ, Alikhani L, Wang J, Sowa A, Groen K, Perry B, Dickstein DL, Baulch JE, Limoli CL, Britten RA. PMID: 33915974; PMCID: PMC8036585.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    33. Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung. Front Oncol. 2020; 10:602763. Montay-Gruel P, Zhu Y, Petit B, Leavitt R, Warn M, Giedzinski E, Ollivier J, Sinclair DA, Vozenin MC, Limoli CL. PMID: 33738245; PMCID: PMC7962869.
      View in: PubMed   Mentions: 5  
    34. Detrimental impacts of mixed-ion radiation on nervous system function. Neurobiol Dis. 2021 04; 151:105252. Klein PM, Parihar VK, Szabo GG, Zöldi M, Angulo MC, Allen BD, Amin AN, Nguyen QA, Katona I, Baulch JE, Limoli CL, Soltesz I. PMID: 33418069.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    35. Systemic HDAC3 inhibition ameliorates impairments in synaptic plasticity caused by simulated galactic cosmic radiation exposure in male mice. Neurobiol Learn Mem. 2021 02; 178:107367. Keiser AA, Kramár EA, Dong T, Shanur S, Pirodan M, Ru N, Acharya MM, Baulch JE, Limoli CL, Wood MA. PMID: 33359392; PMCID: PMC8456980.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    36. All Irradiations that are Ultra-High Dose Rate may not be FLASH: The Critical Importance of Beam Parameter Characterization and In Vivo Validation of the FLASH Effect. Radiat Res. 2020 Dec 01; 194(6):571-572. Vozenin MC, Montay-Gruel P, Limoli C, Germond JF. PMID: 32853355.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    37. Radiation Research Special Issue: New Beam Delivery Modalities are Shaping the Future of Radiotherapy. Radiat Res. 2020 12 01; 194(6):567-570. Griffin RJ, Limoli CL, Simone CB. PMID: 32926736; PMCID: PMC7855553.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Ultra-High-Dose-Rate FLASH Irradiation Limits Reactive Gliosis in the Brain. Radiat Res. 2020 12 01; 194(6):636-645. Montay-Gruel P, Markarian M, Allen BD, Baddour JD, Giedzinski E, Jorge PG, Petit B, Bailat C, Vozenin MC, Limoli C, Acharya MM. PMID: 32853387; PMCID: PMC7856066.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsPHPublic Health
    39. Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation. Radiat Res. 2020 12 01; 194(6):625-635. Allen BD, Acharya MM, Montay-Gruel P, Jorge PG, Bailat C, Petit B, Vozenin MC, Limoli C. PMID: 33348373; PMCID: PMC7773228.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    40. Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in Mice. Clin Cancer Res. 2021 02 01; 27(3):775-784. Montay-Gruel P, Acharya MM, Gonçalves Jorge P, Petit B, Petridis IG, Fuchs P, Leavitt R, Petersson K, Gondré M, Ollivier J, Moeckli R, Bochud F, Bailat C, Bourhis J, Germond JF, Limoli CL, Vozenin MC. PMID: 33060122; PMCID: PMC7854480.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsPHPublic Health
    41. Can a comparison of clinical and deep space irradiation scenarios shed light on the radiation response of the brain? Br J Radiol. 2020 Nov 01; 93(1115):20200245. Limoli C. PMID: 32970457; PMCID: PMC8519643.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    42. Sex-Specific Cognitive Deficits Following Space Radiation Exposure. Front Behav Neurosci. 2020; 14:535885. Parihar VK, Angulo MC, Allen BD, Syage A, Usmani MT, Passerat de la Chapelle E, Amin AN, Flores L, Lin X, Giedzinski E, Limoli CL. PMID: 33192361; PMCID: PMC7525092.
      View in: PubMed   Mentions: 17  
    43. Extracellular Vesicle-Derived miR-124 Resolves Radiation-Induced Brain Injury. Cancer Res. 2020 10 01; 80(19):4266-4277. Leavitt RJ, Acharya MM, Baulch JE, Limoli CL. PMID: 32816912; PMCID: PMC7541572.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    44. Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation. Cancers (Basel). 2020 Jun 24; 12(6). Alaghband Y, Cheeks SN, Allen BD, Montay-Gruel P, Doan NL, Petit B, Jorge PG, Giedzinski E, Acharya MM, Vozenin MC, Limoli CL. PMID: 32599789; PMCID: PMC7352849.
      View in: PubMed   Mentions: 36  
    45. Evaluating different routes of extracellular vesicle administration for cranial therapies. J Cancer Metastasis Treat. 2020; 6(15). Ioannides P, Giedzinski E, Limoli CL. PMID: 34277952; PMCID: PMC8281946.
      View in: PubMed   Mentions: 6  
    46. Mitigation of helium irradiation-induced brain injury by microglia depletion. J Neuroinflammation. 2020 May 19; 17(1):159. Allen BD, Syage AR, Maroso M, Baddour AAD, Luong V, Minasyan H, Giedzinski E, West BL, Soltesz I, Limoli CL, Baulch JE, Acharya MM. PMID: 32429943; PMCID: PMC7236926.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    47. Role of Exosomes in Cancer-Related Cognitive Impairment. Int J Mol Sci. 2020 Apr 15; 21(8). Koh YQ, Tan CJ, Toh YL, Sze SK, Ho HK, Limoli CL, Chan A. PMID: 32326653; PMCID: PMC7215650.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Understanding High-Dose, Ultra-High Dose Rate, and Spatially Fractionated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2020 07 15; 107(4):766-778. Griffin RJ, Ahmed MM, Amendola B, Belyakov O, Bentzen SM, Butterworth KT, Chang S, Coleman CN, Djonov V, Formenti SC, Glatstein E, Guha C, Kalnicki S, Le QT, Loo BW, Mahadevan A, Massaccesi M, Maxim PG, Mohiuddin M, Mohiuddin M, Mayr NA, Obcemea C, Petersson K, Regine W, Roach M, Romanelli P, Simone CB, Snider JW, Spitz DR, Vikram B, Vozenin MC, Abdel-Wahab M, Welsh J, Wu X, Limoli CL. PMID: 32298811.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    49. Response to Ling et al. regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses". Radiother Oncol. 2020 06; 147:241-242. Buettner GR, Spitz DR, Limoli CL. PMID: 32222332; PMCID: PMC8757288.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Neurological Impairments in Mice Subjected to Irradiation and Chemotherapy. Radiat Res. 2020 05; 193(5):407-424. Dey D, Parihar VK, Szabo GG, Klein PM, Tran J, Moayyad J, Ahmed F, Nguyen QA, Murry A, Merriott D, Nguyen B, Goldman J, Angulo MC, Piomelli D, Soltesz I, Baulch JE, Limoli CL. PMID: 32134362; PMCID: PMC7334540.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    51. Response to the Commentary from Bevelacqua et al. eNeuro. 2020 Jan/Feb; 7(1). Limoli CL, Britten R, Baulch J, Borak T. PMID: 31857345; PMCID: PMC7031857.
      View in: PubMed   Mentions: 1     Fields:    
    52. Spatially fractionated radiation therapy: History, present and the future. Clin Transl Radiat Oncol. 2020 Jan; 20:30-38. Yan W, Khan MK, Wu X, Simone CB, Fan J, Gressen E, Zhang X, Limoli CL, Bahig H, Tubin S, Mourad WF. PMID: 31768424; PMCID: PMC6872856.
      View in: PubMed   Mentions: 36  
    53. Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain. Stem Cells Transl Med. 2020 01; 9(1):93-105. Smith SM, Giedzinski E, Angulo MC, Lui T, Lu C, Park AL, Tang S, Martirosian V, Ru N, Chmielewski NN, Liang Y, Baulch JE, Acharya MM, Limoli CL. PMID: 31568685; PMCID: PMC6954724.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    54. New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation. eNeuro. 2019 Jul/Aug; 6(4). Acharya MM, Baulch JE, Klein PM, Baddour AAD, Apodaca LA, Kramár EA, Alikhani L, Garcia C, Angulo MC, Batra RS, Fallgren CM, Borak TB, Stark CEL, Wood MA, Britten RA, Soltesz I, Limoli CL. PMID: 31383727; PMCID: PMC6709229.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    55. Response to letter regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses". Radiother Oncol. 2019 10; 139:64-65. Spitz DR, Buettner GR, Limoli CL. PMID: 31427044; PMCID: PMC7254962.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    56. Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice. Sci Rep. 2019 07 01; 9(1):9460. Hinzman CP, Baulch JE, Mehta KY, Girgis M, Bansal S, Gill K, Li Y, Limoli CL, Cheema AK. PMID: 31263197; PMCID: PMC6603161.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    57. Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10943-10951. Montay-Gruel P, Acharya MM, Petersson K, Alikhani L, Yakkala C, Allen BD, Ollivier J, Petit B, Jorge PG, Syage AR, Nguyen TA, Baddour AAD, Lu C, Singh P, Moeckli R, Bochud F, Germond JF, Froidevaux P, Bailat C, Bourhis J, Vozenin MC, Limoli CL. PMID: 31097580; PMCID: PMC6561167.
      View in: PubMed   Mentions: 120     Fields:    Translation:Animals
    58. Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken. Clin Oncol (R Coll Radiol). 2019 07; 31(7):407-415. Vozenin MC, Hendry JH, Limoli CL. PMID: 31010708; PMCID: PMC6850216.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    59. An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. Radiother Oncol. 2019 10; 139:23-27. Spitz DR, Buettner GR, Petronek MS, St-Aubin JJ, Flynn RT, Waldron TJ, Limoli CL. PMID: 31010709; PMCID: PMC6761031.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    60. Alterations in synaptic density and myelination in response to exposure to high-energy charged particles. J Comp Neurol. 2018 12 01; 526(17):2845-2855. Dickstein DL, Talty R, Bresnahan E, Varghese M, Perry B, Janssen WGM, Sowa A, Giedzinski E, Apodaca L, Baulch J, Acharya M, Parihar V, Limoli CL. PMID: 30198564; PMCID: PMC6442721.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    61. miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury. Int J Radiat Biol. 2019 04; 95(4):427-435. Leavitt RJ, Limoli CL, Baulch JE. PMID: 30252569; PMCID: PMC6433537.
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    62. Exposure to Ionizing Radiation Causes Endoplasmic Reticulum Stress in the Mouse Hippocampus. Radiat Res. 2018 11; 190(5):483-493. Hinzman CP, Baulch JE, Mehta KY, Gill K, Limoli CL, Cheema AK. PMID: 30084740; PMCID: PMC6855183.
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    63. Stochastic Modeling of Radiation-induced Dendritic Damage on in silico Mouse Hippocampal Neurons. Sci Rep. 2018 04 03; 8(1):5494. Cacao E, Parihar VK, Limoli CL, Cucinotta FA. PMID: 29615729; PMCID: PMC5882641.
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    64. Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice. Exp Neurol. 2018 07; 305:44-55. Parihar VK, Maroso M, Syage A, Allen BD, Angulo MC, Soltesz I, Limoli CL. PMID: 29540322.
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    65. Remediation of Radiation-Induced Cognitive Dysfunction through Oral Administration of the Neuroprotective Compound NSI-189. Radiat Res. 2018 04; 189(4):345-353. Allen BD, Acharya MM, Lu C, Giedzinski E, Chmielewski NN, Quach D, Hefferan M, Johe KK, Limoli CL. PMID: 29351056; PMCID: PMC5910029.
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    66. Space-brain: The negative effects of space exposure on the central nervous system. Surg Neurol Int. 2018; 9:9. Jandial R, Hoshide R, Waters JD, Limoli CL. PMID: 29416906; PMCID: PMC5791508.
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    67. Stem Cell Therapies for the Resolution of Radiation Injury to the Brain. Curr Stem Cell Rep. 2017 Dec; 3(4):342-347. Smith SM, Limoli CL. PMID: 29423356; PMCID: PMC5798632.
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    68. The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. Oncotarget. 2017 Oct 06; 8(46):80853-80868. Zhou YH, Chen Y, Hu Y, Yu L, Tran K, Giedzinski E, Ru N, Gau A, Pan F, Qiao J, Atkin N, Ly KC, Lee N, Siegel ER, Linskey ME, Wang P, Limoli C. PMID: 29113349; PMCID: PMC5655244.
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    69. Corrigendum: Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci. 2017; 10:218. Acharya MM, Baulch JE, Lusardi TA, Allen BD, Chmielewski NN, Baddour AAD, Limoli CL, Boison D. PMID: 28698714; PMCID: PMC5502282.
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    70. Lessons learned from an unstable genomic landscape. Int J Radiat Biol. 2017 10; 93(10):1177-1181. Limoli CL. PMID: 28054831.
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    71. Deep-Space Deal Breaker. Sci Am. 2017 Jan 17; 316(2):54-59. Limoli CL. PMID: 28118333.
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    72. Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission. Brain Struct Funct. 2017 Jul; 222(5):2345-2357. Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I. PMID: 27905022; PMCID: PMC5504243.
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    73. Cosmic radiation exposure and persistent cognitive dysfunction. Sci Rep. 2016 10 10; 6:34774. Parihar VK, Allen BD, Caressi C, Kwok S, Chu E, Tran KK, Chmielewski NN, Giedzinski E, Acharya MM, Britten RA, Baulch JE, Limoli CL. PMID: 27721383; PMCID: PMC5056393.
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    74. Elimination of microglia improves cognitive function following cranial irradiation. Sci Rep. 2016 08 12; 6:31545. Acharya MM, Green KN, Allen BD, Najafi AR, Syage A, Minasyan H, Le MT, Kawashita T, Giedzinski E, Parihar VK, West BL, Baulch JE, Limoli CL. PMID: 27516055; PMCID: PMC4981848.
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    75. Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium. Sci Rep. 2016 07 28; 6:29901. Delp MD, Charvat JM, Limoli CL, Globus RK, Ghosh P. PMID: 27467019; PMCID: PMC4964660.
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    76. Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci. 2016; 9:42. Acharya MM, Baulch JE, Lusardi TA, Allen BD, Chmielewski NN, Baddour AA, Limoli CL, Boison D. PMID: 27375429; PMCID: PMC4891332.
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    77. Understanding and targeting dynamic stress responses of the brain: What we have learned and how to improve neurocognitive outcome following neurotoxic insult. Environ Mol Mutagen. 2016 06; 57(5):319-21. Limoli CL. PMID: 27208487.
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    78. 3D surface analysis of hippocampal microvasculature in the irradiated brain. Environ Mol Mutagen. 2016 06; 57(5):341-9. Craver BM, Acharya MM, Allen BD, Benke SN, Hultgren NW, Baulch JE, Limoli CL. PMID: 27175611; PMCID: PMC4912407.
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    79. Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4836-41. Baulch JE, Acharya MM, Allen BD, Ru N, Chmielewski NN, Martirosian V, Giedzinski E, Syage A, Park AL, Benke SN, Parihar VK, Limoli CL. PMID: 27044087; PMCID: PMC4855546.
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    80. Contrasting the effects of proton irradiation on dendritic complexity of subiculum neurons in wild type and MCAT mice. Environ Mol Mutagen. 2016 06; 57(5):364-71. Chmielewski NN, Caressi C, Giedzinski E, Parihar VK, Limoli CL. PMID: 26996825.
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    81. Dried plum diet protects from bone loss caused by ionizing radiation. Sci Rep. 2016 Feb 11; 6:21343. Schreurs AS, Shirazi-Fard Y, Shahnazari M, Alwood JS, Truong TA, Tahimic CG, Limoli CL, Turner ND, Halloran B, Globus RK. PMID: 26867002; PMCID: PMC4750446.
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    82. William F. Morgan (1952-2015). Radiat Res. 2016 Jan; 185(1):106-8. Limoli C, Baulch J, Sowa M. PMID: 26789848.
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    83. Irradiation of primary human gliomas triggers dynamic and aggressive survival responses involving microvesicle signaling. Environ Mol Mutagen. 2016 06; 57(5):405-15. Baulch JE, Geidzinski E, Tran KK, Yu L, Zhou YH, Limoli CL. PMID: 26602180.
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    84. Irradiation of Neurons with High-Energy Charged Particles: An In Silico Modeling Approach. PLoS Comput Biol. 2015 Aug; 11(8):e1004428. Alp M, Parihar VK, Limoli CL, Cucinotta FA. PMID: 26252394; PMCID: PMC4529238.
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    85. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. J Neurosci. 2015 Jul 08; 35(27):10039-57. Lee SH, Ledri M, Tóth B, Marchionni I, Henstridge CM, Dudok B, Kenesei K, Barna L, Szabó SI, Renkecz T, Oberoi M, Watanabe M, Limoli CL, Horvai G, Soltesz I, Katona I. PMID: 26157003; PMCID: PMC4495235.
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    86. Your Brain on Mars. Radiat Res. 2015 Jul; 184(1):1-2. Limoli C. PMID: 26066080.
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    87. Consequences of low dose ionizing radiation exposure on the hippocampal microenvironment. PLoS One. 2015; 10(6):e0128316. Acharya MM, Patel NH, Craver BM, Tran KK, Giedzinski E, Tseng BP, Parihar VK, Limoli CL. PMID: 26042591; PMCID: PMC4456101.
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    88. What happens to your brain on the way to Mars. Sci Adv. 2015 May 01; 1(4). Parihar VK, Allen B, Tran KK, Macaraeg TG, Chu EM, Kwok SF, Chmielewski NN, Craver BM, Baulch JE, Acharya MM, Cucinotta FA, Limoli CL. PMID: 26180843; PMCID: PMC4500198.
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    89. Persistent oxidative stress in human neural stem cells exposed to low fluences of charged particles. Redox Biol. 2015 Aug; 5:24-32. Baulch JE, Craver BM, Tran KK, Yu L, Chmielewski N, Allen BD, Limoli CL. PMID: 25800120; PMCID: PMC4371546.
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    90. Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction. Cancer Res. 2015 Feb 15; 75(4):676-86. Acharya MM, Martirosian V, Chmielewski NN, Hanna N, Tran KK, Liao AC, Christie LA, Parihar VK, Limoli CL. PMID: 25687405; PMCID: PMC4332567.
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    91. Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction. Antioxid Redox Signal. 2015 Jan 01; 22(1):78-91. Parihar VK, Allen BD, Tran KK, Chmielewski NN, Craver BM, Martirosian V, Morganti JM, Rosi S, Vlkolinsky R, Acharya MM, Nelson GA, Allen AR, Limoli CL. PMID: 24949841; PMCID: PMC4270160.
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    92. Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment. Stem Cells Transl Med. 2015 Jan; 4(1):74-83. Acharya MM, Martirosian V, Christie LA, Riparip L, Strnadel J, Parihar VK, Limoli CL. PMID: 25391646; PMCID: PMC4275007.
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    93. Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus. Cell Transplant. 2015; 24(4):691-702. Acharya MM, Rosi S, Jopson T, Limoli CL. PMID: 25289634; PMCID: PMC5027839.
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    94. Long-term cognitive effects of human stem cell transplantation in the irradiated brain. Int J Radiat Biol. 2014 Sep; 90(9):816-20. Acharya MM, Martirosian V, Christie LA, Limoli CL. PMID: 24882389; PMCID: PMC5027837.
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    95. Defining functional changes in the brain caused by targeted stereotaxic radiosurgery. Transl Cancer Res. 2014 Apr 01; 3(2):124-137. Parihar VK, Acharya MM, Roa DE, Bosch O, Christie LA, Limoli CL. PMID: 24904783; PMCID: PMC4043313.
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    96. Linking differential radiation responses to glioma heterogeneity. Oncotarget. 2014 Mar 30; 5(6):1657-65. Ke C, Tran K, Chen Y, Di Donato AT, Yu L, Hu Y, Linskey ME, Wang PH, Limoli CL, Zhou YH. PMID: 24722169; PMCID: PMC4039238.
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    97. Stem cell therapies for the treatment of radiation-induced normal tissue side effects. Antioxid Redox Signal. 2014 07 10; 21(2):338-55. Benderitter M, Caviggioli F, Chapel A, Coppes RP, Guha C, Klinger M, Malard O, Stewart F, Tamarat R, van Luijk P, Limoli CL. PMID: 24147585; PMCID: PMC4060814.
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    98. Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation. Brain Struct Funct. 2015 Mar; 220(2):1161-71. Parihar VK, Pasha J, Tran KK, Craver BM, Acharya MM, Limoli CL. PMID: 24446074; PMCID: PMC4105336.
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    99. Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. PLoS One. 2013; 8(11):e80898. Hu Y, Ru N, Xiao H, Chaturbedi A, Hoa NT, Tian XJ, Zhang H, Ke C, Yan F, Nelson J, Li Z, Gramer R, Yu L, Siegel E, Zhang X, Jia Z, Jadus MR, Limoli CL, Linskey ME, Xing J, Zhou YH. PMID: 24282558; PMCID: PMC3839911.
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    100. Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation. Antioxid Redox Signal. 2014 Mar 20; 20(9):1410-22. Tseng BP, Giedzinski E, Izadi A, Suarez T, Lan ML, Tran KK, Acharya MM, Nelson GA, Raber J, Parihar VK, Limoli CL. PMID: 23802883; PMCID: PMC3936501.
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    101. Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation. Cell Transplant. 2014; 23(10):1255-66. Acharya MM, Christie LA, Hazel TG, Johe KK, Limoli CL. PMID: 23866792; PMCID: PMC3895108.
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    102. Cranial irradiation compromises neuronal architecture in the hippocampus. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12822-7. Parihar VK, Limoli CL. PMID: 23858442; PMCID: PMC3732939.
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    103. Mitochondrial-targeted human catalase affords neuroprotection from proton irradiation. Radiat Res. 2013 Jul; 180(1):1-6. Liao AC, Craver BM, Tseng BP, Tran KK, Parihar VK, Acharya MM, Limoli CL. PMID: 23672429.
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    104. Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria. J Neurochem. 2013 Apr; 125(2):303-13. Olsen RH, Johnson LA, Zuloaga DG, Limoli CL, Raber J. PMID: 23383735; PMCID: PMC3676474.
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    105. Characterizing low dose and dose rate effects in rodent and human neural stem cells exposed to proton and gamma irradiation. Redox Biol. 2013; 1:153-62. Tseng BP, Lan ML, Tran KK, Acharya MM, Giedzinski E, Limoli CL. PMID: 24024148; PMCID: PMC3757683.
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    106. Characterizing the radioresponse of pluripotent and multipotent human stem cells. PLoS One. 2012; 7(12):e50048. Lan ML, Acharya MM, Tran KK, Bahari-Kashani J, Patel NH, Strnadel J, Giedzinski E, Limoli CL. PMID: 23272054; PMCID: PMC3522689.
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    107. SU-E-T-271: Irradiating a Single Hippocampus in a Small Rodent Using VMAT- RapidArc SRS: Preliminary Data. Med Phys. 2012 Jun; 39(6Part14):3765-3766. Lin Y, Limoli C, Acharya M, Christie L, Bosch O, Kumar V, Hamamura M, Roa D. PMID: 28517275.
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    108. Comparing the functional consequences of human stem cell transplantation in the irradiated rat brain. Cell Transplant. 2013; 22(1):55-64. Acharya MM, Christie LA, Lan ML, Limoli CL. PMID: 22546529; PMCID: PMC3601190.
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    109. Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture. J Aging Res. 2012; 2012:481983. Alwood JS, Kumar A, Tran LH, Wang A, Limoli CL, Globus RK. PMID: 22570786; PMCID: PMC3337602.
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    110. Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy. Clin Cancer Res. 2012 Apr 01; 18(7):1954-65. Christie LA, Acharya MM, Parihar VK, Nguyen A, Martirosian V, Limoli CL. PMID: 22338017.
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    111. Quantifying cognitive decrements caused by cranial radiotherapy. J Vis Exp. 2011 Oct 18; (56). Christie LA, Acharya MM, Limoli CL. PMID: 22042060; PMCID: PMC3227186.
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    112. Stem cell transplantation strategies for the restoration of cognitive dysfunction caused by cranial radiotherapy. J Vis Exp. 2011 Oct 18; (56). Acharya MM, Roa DE, Bosch O, Lan ML, Limoli CL. PMID: 22042021; PMCID: PMC3227184.
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    113. Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction. Cancer Res. 2011 Jul 15; 71(14):4834-45. Acharya MM, Christie LA, Lan ML, Giedzinski E, Fike JR, Rosi S, Limoli CL. PMID: 21757460; PMCID: PMC3517293.
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    114. PROBING THE IMPACT OF GAMMA-IRRADIATION ON THE METABOLIC STATE OF NEURAL STEM AND PRECURSOR CELLS USING DUAL-WAVELENGTH INTRINSIC SIGNAL TWO-PHOTON EXCITED FLUORESCENCE. J Innov Opt Health Sci. 2011 Jul 01; 4(3):289-300. Krasieva TB, Giedzinski E, Tran K, Lan M, Limoli CL, Tromberg BJ. PMID: 23869199; PMCID: PMC3712535.
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    115. Satellite cells say NO to radiation. Radiat Res. 2011 May; 175(5):561-8. Cho-Lim JJ, Caiozzo VJ, Tseng BP, Giedzinski E, Baker MJ, Limoli CL. PMID: 21319985; PMCID: PMC4049230.
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    116. Consequences of ionizing radiation-induced damage in human neural stem cells. Free Radic Biol Med. 2010 Dec 15; 49(12):1846-55. Acharya MM, Lan ML, Kan VH, Patel NH, Giedzinski E, Tseng BP, Limoli CL. PMID: 20826207.
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    117. The radiosensitivity of satellite cells: cell cycle regulation, apoptosis and oxidative stress. Radiat Res. 2010 Nov; 174(5):582-9. Caiozzo VJ, Giedzinski E, Baker M, Suarez T, Izadi A, Lan M, Cho-Lim J, Tseng BP, Limoli CL. PMID: 20726709; PMCID: PMC4049262.
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    118. Heavy ion irradiation and unloading effects on mouse lumbar vertebral microarchitecture, mechanical properties and tissue stresses. Bone. 2010 Aug; 47(2):248-55. Alwood JS, Yumoto K, Mojarrab R, Limoli CL, Almeida EA, Searby ND, Globus RK. PMID: 20466089.
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    119. Short-term effects of whole-body exposure to (56)fe ions in combination with musculoskeletal disuse on bone cells. Radiat Res. 2010 Apr; 173(4):494-504. Yumoto K, Globus RK, Mojarrab R, Arakaki J, Wang A, Searby ND, Almeida EA, Limoli CL. PMID: 20334522.
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    120. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiat Res. 2009 Dec; 172(6):737-45. Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, Pain D, Limoli CL, Goswami PC, Domann FE, Spitz DR. PMID: 19929420; PMCID: PMC2793528.
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    121. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19150-5. Acharya MM, Christie LA, Lan ML, Donovan PJ, Cotman CW, Fike JR, Limoli CL. PMID: 19901336; PMCID: PMC2776427.
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    122. Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse. J Appl Physiol (1985). 2010 Jan; 108(1):152-61. Kondo H, Yumoto K, Alwood JS, Mojarrab R, Wang A, Almeida EA, Searby ND, Limoli CL, Globus RK. PMID: 19875718; PMCID: PMC2885070.
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    123. Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD. Free Radic Biol Med. 2009 Nov 15; 47(10):1459-67. Fishman K, Baure J, Zou Y, Huang TT, Andres-Mach M, Rola R, Suarez T, Acharya M, Limoli CL, Lamborn KR, Fike JR. PMID: 19703553; PMCID: PMC2767469.
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    124. Neural precursor cells and central nervous system radiation sensitivity. Semin Radiat Oncol. 2009 Apr; 19(2):122-32. Fike JR, Rosi S, Limoli CL. PMID: 19249650; PMCID: PMC2683587.
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    125. Total-body irradiation of postpubertal mice with (137)Cs acutely compromises the microarchitecture of cancellous bone and increases osteoclasts. Radiat Res. 2009 Mar; 171(3):283-9. Kondo H, Searby ND, Mojarrab R, Phillips J, Alwood J, Yumoto K, Almeida EA, Limoli CL, Globus RK. PMID: 19267555.
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    126. Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death. Mutagenesis. 2009 May; 24(3):211-24. Cortes-Wanstreet MM, Giedzinski E, Limoli CL, Luderer U. PMID: 19153097; PMCID: PMC2674984.
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    127. Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity. Mutagenesis. 2009 Mar; 24(2):161-7. Baure J, Izadi A, Suarez V, Giedzinski E, Cleaver JE, Fike JR, Limoli CL. PMID: 19064695; PMCID: PMC2648872.
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    128. Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells. Biochem J. 2008 Jul 01; 413(1):185-91. Dayal D, Martin SM, Limoli CL, Spitz DR. PMID: 18352860; PMCID: PMC2677991.
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    129. Low doses of very low-dose-rate low-LET radiation suppress radiation-induced neoplastic transformation in vitro and induce an adaptive response. Radiat Res. 2008 Mar; 169(3):311-8. Elmore E, Lao XY, Kapadia R, Giedzinski E, Limoli C, Redpath JL. PMID: 18302492.
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    130. Shared oxidative pathways in response to gravity-dependent loading and gamma-irradiation of bone marrow-derived skeletal cell progenitors. Radiats Biol Radioecol. 2007 May-Jun; 47(3):281-5. Kondo H, Limoli C, Searby ND, Almeida EA, Loftus DJ, Vercoutere W, Morey-Holton E, Giedzinski E, Mojarrab R, Hilton D, Globus RK. PMID: 17867495.
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    131. Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea. Oncogene. 2007 Aug 23; 26(39):5713-21. de Feraudy S, Limoli CL, Giedzinski E, Karentz D, Marti TM, Feeney L, Cleaver JE. PMID: 17369853.
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    132. Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis. Free Radic Biol Med. 2007 Apr 15; 42(8):1133-45; discussion 1131-2. Rola R, Zou Y, Huang TT, Fishman K, Baure J, Rosi S, Milliken H, Limoli CL, Fike JR. PMID: 17382195; PMCID: PMC1934512.
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    133. Radiation response of neural precursor cells. Neurosurg Clin N Am. 2007 Jan; 18(1):115-27, x. Fike JR, Rola R, Limoli CL. PMID: 17244559.
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    134. Using superoxide dismutase/catalase mimetics to manipulate the redox environment of neural precursor cells. Radiat Prot Dosimetry. 2006; 122(1-4):228-36. Limoli CL, Giedzinski E, Baure J, Doctrow SR, Rola R, Fike JR. PMID: 17166877.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    135. Redox changes induced in hippocampal precursor cells by heavy ion irradiation. Radiat Environ Biophys. 2007 Jun; 46(2):167-72. Limoli CL, Giedzinski E, Baure J, Rola R, Fike JR. PMID: 17103219.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    136. Altered growth and radiosensitivity in neural precursor cells subjected to oxidative stress. Int J Radiat Biol. 2006 Sep; 82(9):640-7. Limoli CL, Giedzinski E, Baure J, Rola R, Fike JR. PMID: 17050476.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    137. High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis. Radiat Res. 2005 Oct; 164(4 Pt 2):556-60. Rola R, Sarkissian V, Obenaus A, Nelson GA, Otsuka S, Limoli CL, Fike JR. PMID: 16187787.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    138. Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protons. Radiat Res. 2005 Oct; 164(4 Pt 2):540-4. Giedzinski E, Rola R, Fike JR, Limoli CL. PMID: 16187784.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    139. Alternative recombination pathways in UV-irradiated XP variant cells. Oncogene. 2005 May 26; 24(23):3708-14. Limoli CL, Giedzinski E, Cleaver JE. PMID: 15750628.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    140. Cell-density-dependent regulation of neural precursor cell function. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16052-7. Limoli CL, Rola R, Giedzinski E, Mantha S, Huang TT, Fike JR. PMID: 15522966; PMCID: PMC528770.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    141. Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dose-dependent manner. Radiat Res. 2004 Oct; 162(4):442-6. Rola R, Otsuka S, Obenaus A, Nelson GA, Limoli CL, VandenBerg SR, Fike JR. PMID: 15447038.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    142. Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat Res. 2004 Jan; 161(1):17-27. Limoli CL, Giedzinski E, Rola R, Otsuka S, Palmer TD, Fike JR. PMID: 14680400.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    143. Induction of chromosomal instability by chronic oxidative stress. Neoplasia. 2003 Jul-Aug; 5(4):339-46. Limoli CL, Giedzinski E. PMID: 14511405; PMCID: PMC1502421.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    144. DNA replication in the face of (In)surmountable odds. Cell Cycle. 2003 Jul-Aug; 2(4):310-5. Cleaver JE, Laposa RR, Limoli CL. PMID: 12851481.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    145. Persistent oxidative stress in chromosomally unstable cells. Cancer Res. 2003 Jun 15; 63(12):3107-11. Limoli CL, Giedzinski E, Morgan WF, Swarts SG, Jones GD, Hyun W. PMID: 12810636.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    146. Bystander effects in radiation-induced genomic instability. Mutat Res. 2002 Jul 25; 504(1-2):91-100. Morgan WF, Hartmann A, Limoli CL, Nagar S, Ponnaiya B. PMID: 12106650.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    147. Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation. DNA Repair (Amst). 2002 Jan 22; 1(1):41-57. Cleaver JE, Bartholomew J, Char D, Crowley E, Feeney L, Limoli CL. PMID: 12509296.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    148. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):233-8. Limoli CL, Giedzinski E, Bonner WM, Cleaver JE. PMID: 11756691; PMCID: PMC117544.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    149. DNA Replication Arrest and P53-Dependent and P53-Independent Cell Death Pathways in Xeroderma Pigmentosum Variant Cells. ScientificWorldJournal. 2001; 1:60. Cleaver JE, Crowley E, Kashani-Sabet M, Limoli CL. PMID: 30147530; PMCID: PMC6084123.
      View in: PubMed   Mentions:    Fields:    
    150. Attenuation of radiation-induced genomic instability by free radical scavengers and cellular proliferation. Free Radic Biol Med. 2001 Jul 01; 31(1):10-9. Limoli CL, Kaplan MI, Giedzinski E, Morgan WF. PMID: 11425485.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    151. Nucleotide excision repair "a legacy of creativity". Mutat Res. 2001 Feb 25; 485(1):23-36. Cleaver JE, Karplus K, Kashani-Sabet M, Limoli CL. PMID: 11341991.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    152. DNA strand break yields after post-high LET irradiation incubation with endonuclease-III and evidence for hydroxyl radical clustering. Int J Radiat Biol. 2001 Feb; 77(2):155-64. Milligan JR, Aguilera JA, Paglinawan RA, Ward JF, Limoli CL. PMID: 11236922.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    153. Chromosomal instability induced by heavy ion irradiation. Int J Radiat Biol. 2000 Dec; 76(12):1599-606. Limoli CL, Ponnaiya B, Corcoran JJ, Giedzinski E, Morgan WF. PMID: 11133041.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    154. Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7939-46. Limoli CL, Giedzinski E, Morgan WF, Cleaver JE. PMID: 10859352; PMCID: PMC16649.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    155. Genomic instability induced by high and low LET ionizing radiation. Adv Space Res. 2000; 25(10):2107-17. Limoli CL, Ponnaiya B, Corcoran JJ, Giedzinski E, Kaplan MI, Hartmann A, Morgan WF. PMID: 11542863.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    156. Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation. Radiat Res. 1999 Jun; 151(6):677-85. Limoli CL, Corcoran JJ, Milligan JR, Ward JF, Morgan WF. PMID: 10360787.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    157. The evolution of chromosomal instability in Chinese hamster cells: a changing picture? Int J Radiat Biol. 1998 Dec; 74(6):765-70. Ponnaiya B, Limoli CL, Corcoran J, Kaplan MI, Hartmann A, Morgan WF. PMID: 9881722.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    158. Apoptosis, reproductive failure, and oxidative stress in Chinese hamster ovary cells with compromised genomic integrity. Cancer Res. 1998 Aug 15; 58(16):3712-8. Limoli CL, Hartmann A, Shephard L, Yang CR, Boothman DA, Bartholomew J, Morgan WF. PMID: 9721883.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    159. DNA double-strand breaks, chromosomal rearrangements, and genomic instability. Mutat Res. 1998 Aug 03; 404(1-2):125-8. Morgan WF, Corcoran J, Hartmann A, Kaplan MI, Limoli CL, Ponnaiya B. PMID: 9729329.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    160. Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells. Carcinogenesis. 1998 Feb; 19(2):259-65. Day JP, Limoli CL, Morgan WF. PMID: 9498274.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    161. Induction of chromosome aberrations and delayed genomic instability by photochemical processes. Photochem Photobiol. 1998 Feb; 67(2):233-8. Limoli CL, Day JP, Ward JF, Morgan WF. PMID: 9487801.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    162. Chromosomal instability and its relationship to other end points of genomic instability. Cancer Res. 1997 Dec 15; 57(24):5557-63. Limoli CL, Kaplan MI, Corcoran J, Meyers M, Boothman DA, Morgan WF. PMID: 9407967.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    163. Photochemical production of uracil quantified in bromodeoxyuridine-substituted SV40 DNA by uracil DNA glycosylase and a lysyl-tyrosyl-lysine tripeptide. Mutagenesis. 1997 Nov; 12(6):443-7. Limoli CL, Wu CC, Milligan JR, Ward JF. PMID: 9412998.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    164. Differential induction of chromosomal instability by DNA strand-breaking agents. Cancer Res. 1997 Sep 15; 57(18):4048-56. Limoli CL, Kaplan MI, Phillips JW, Adair GM, Morgan WF. PMID: 9307292.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    165. Perpetuating radiation-induced chromosomal instability. Radiat Oncol Investig. 1997; 5(3):124-8. Kaplan MI, Limoli CL, Morgan WF. PMID: 9303069.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    166. Genomic instability induced by ionizing radiation. Radiat Res. 1996 Sep; 146(3):247-58. Morgan WF, Day JP, Kaplan MI, McGhee EM, Limoli CL. PMID: 8752302.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    167. Photochemical production of double-strand breaks in cellular DNA. Mutagenesis. 1995 Sep; 10(5):453-6. Limoli CL, Ward JF. PMID: 8544761.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    168. Mechanisms of radiosensitization in iododeoxyuridine-substituted cells. Int J Radiat Biol. 1995 Jun; 67(6):647-53. Jones GD, Ward JF, Limoli CL, Moyer DJ, Aguilera JA. PMID: 7608627.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    169. DNA damage in bromodeoxyuridine substituted SV40 DNA and minichromosomes following UVA irradiation in the presence of Hoechst dye 33258. Int J Radiat Biol. 1994 Dec; 66(6):717-28. Limoli CL, Ward JF. PMID: 7529295.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    170. Response of bromodeoxyuridine-substituted Chinese hamster cells to UVA light exposure in the presence of Hoechst dye #33258: survival and DNA repair studies. Radiat Res. 1994 Jun; 138(3):312-9. Limoli CL, Ward JF. PMID: 7514307.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    171. A new method for introducing double-strand breaks into cellular DNA. Radiat Res. 1993 May; 134(2):160-9. Limoli CL, Ward JF. PMID: 7683818.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    172. An examination of the repair saturation hypothesis for describing shouldered survival curves. Radiat Res. 1991 Jul; 127(1):90-6. Ward JF, Limoli CL, Calabro-Jones PM, Aguilera J. PMID: 2068276.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    173. Radiation and hydrogen peroxide induced free radical damage to DNA. Br J Cancer Suppl. 1987 Jun; 8:105-12. Ward JF, Evans JW, Limoli CL, Calabro-Jones PM. PMID: 2820457; PMCID: PMC2149485.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
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