Dennis D Cunningham

Title(s)Professor Emeritus, Microbiology and Molecular Genetics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8349, 7074, 5267
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    Collapse Research 
    Collapse Research Activities and Funding
    Ventilated Mouse Cages for NIH Funded Construction Projects
    NIH G20RR021411Jun 15, 2006 - May 14, 2008
    Role: Principal Investigator
    Extramural Research Facilities Construction Breast &Wo*
    NIH C06RR018796Sep 15, 2005 - Jun 30, 2010
    Role: Principal Investigator
    NIH G20RR018339Feb 1, 2003 - Jan 31, 2004
    Role: Principal Investigator
    NIH C06RR017389Jun 17, 2002 - Jun 16, 2007
    Role: Principal Investigator
    NIH C06RR015491Jun 15, 2001 - Dec 14, 2003
    Role: Principal Investigator
    NIH C06RR014518Sep 30, 1999 - Jun 30, 2004
    Role: Principal Investigator
    NIH R01AG010598Sep 1, 1991 - Aug 31, 1997
    Role: Principal Investigator
    NIH R01GM031609Jul 1, 1983 - Jun 30, 1992
    Role: Principal Investigator
    NIH R01HL027148Apr 1, 1981 - Mar 31, 1986
    Role: Principal Investigator
    NIH R01CA012306Jun 1, 1979 - May 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thrombin receptor signaling to cytoskeleton requires Hsp90. J Biol Chem. 2001 Aug 31; 276(35):32642-7. Pai KS, Mahajan VB, Lau A, Cunningham DD. PMID: 11413145.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    2. Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12062-7. Mahajan VB, Pai KS, Lau A, Cunningham DD. PMID: 11050237; PMCID: PMC17294.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    3. Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line. J Neurochem. 1998 Sep; 71(3):1034-50. Weinstein JR, Lau AL, Brass LF, Cunningham DD. PMID: 9721728.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. Signaling pathways involved in thrombin-induced cell protection. J Biol Chem. 1998 May 22; 273(21):12746-52. Donovan FM, Cunningham DD. PMID: 9582299.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    5. Thrombin causes a marked delay in skeletal myogenesis that correlates with the delayed expression of myogenin and p21CIP1/WAF1. J Biol Chem. 1997 Sep 26; 272(39):24117-20. Guttridge DC, Lau A, Tran L, Cunningham DD. PMID: 9305855.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci. 1997 Jul 15; 17(14):5316-26. Donovan FM, Pike CJ, Cotman CW, Cunningham DD. PMID: 9204916; PMCID: PMC6793831.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    7. Regulation of neurons and astrocytes by thrombin and protease nexin-1. Relationship to brain injury. Adv Exp Med Biol. 1997; 425:67-75. Cunningham DD, Donovan FM. PMID: 9433490.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Characterization of the human protease nexin-1 promoter and its regulation by Sp1 through a G/C-rich activation domain. J Neurochem. 1996 Aug; 67(2):498-507. Guttridge DC, Cunningham DD. PMID: 8764573.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro. J Neurochem. 1996 Apr; 66(4):1374-82. Pike CJ, Vaughan PJ, Cunningham DD, Cotman CW. PMID: 8627288.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    10. Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci. 1995 Jul; 15(7 Pt 2):5389-401. Vaughan PJ, Pike CJ, Cotman CW, Cunningham DD. PMID: 7623161; PMCID: PMC6577903.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    11. Decreases in protease nexins in Alzheimer's disease brain. Neurobiol Aging. 1995 Jul-Aug; 16(4):557-62. Choi BH, Kim RC, Vaughan PJ, Lau A, Van Nostrand WE, Cotman CW, Cunningham DD. PMID: 8544905.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J Neurosci. 1995 Apr; 15(4):2906-19. Weinstein JR, Gold SJ, Cunningham DD, Gall CM. PMID: 7722637; PMCID: PMC6577761.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    13. Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation. J Neurochem. 1995 Feb; 64(2):583-91. Grabham P, Cunningham DD. PMID: 7830051.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease. Brain Res. 1994 Dec 30; 668(1-2):160-70. Vaughan PJ, Su J, Cotman CW, Cunningham DD. PMID: 7704602.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    15. Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor. J Biol Chem. 1994 Sep 09; 269(36):22623-7. Davis-Salinas J, Saporito-Irwin SM, Donovan FM, Cunningham DD, Van Nostrand WE. PMID: 8077213.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. Regulation of protease nexin-1 target protease specificity by collagen type IV. J Biol Chem. 1994 Jun 24; 269(25):17199-205. Donovan FM, Vaughan PJ, Cunningham DD. PMID: 8006028.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates. Brain Res. 1993 Oct 29; 626(1-2):90-8. Wagner SL, Van Nostrand WE, Lau AL, Farrow JS, Suzuki M, Bartus RT, Schuppek R, Nguyen A, Cotman CW, Cunningham DD. PMID: 8281456.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    18. Protease nexin-1, a thrombin inhibitor, is regulated by interleukin-1 and dexamethasone in normal human fibroblasts. J Biol Chem. 1993 Sep 05; 268(25):18966-74. Guttridge DC, Lau AL, Cunningham DD. PMID: 8360185.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Protease nexin-1 and thrombin: injury-related processes in the brain. Thromb Haemost. 1993 Jul 01; 70(1):168-71. Cunningham DD, Pulliam L, Vaughan PJ. PMID: 8236095.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors. J Biol Chem. 1993 Feb 15; 268(5):3720-7. Vaughan PJ, Cunningham DD. PMID: 8429047.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    21. Regulation of neuronal cells and astrocytes by protease nexin-1 and thrombin. Ann N Y Acad Sci. 1992 Dec 31; 674:228-36. Cunningham DD. PMID: 1288365.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 1992 Jun; 48(4):763-77. Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW. PMID: 1378573.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    23. Regulation of protease nexin-1 activity by heparin and heparan sulfate. Adv Exp Med Biol. 1992; 313:297-306. Cunningham DD, Wagner SL, Farrell DH. PMID: 1442266.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10302-6. Van Nostrand WE, Farrow JS, Wagner SL, Bhasin R, Goldgaber D, Cotman CW, Cunningham DD. PMID: 1946448; PMCID: PMC52916.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    25. Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein. Biochem Biophys Res Commun. 1991 Feb 28; 175(1):15-21. Van Nostrand WE, Schmaier AH, Farrow JS, Cines DB, Cunningham DD. PMID: 1900151.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    26. Inhibitors of urokinase and thrombin in cultured neural cells. J Neurochem. 1991 Jan; 56(1):234-42. Wagner SL, Lau AL, Nguyen A, Mimuro J, Loskutoff DJ, Isackson PJ, Cunningham DD. PMID: 1987320.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions. Ann N Y Acad Sci. 1991; 640:140-4. Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD. PMID: 1776731.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    28. Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases. Am J Pathol. 1990 Oct; 137(4):741-7. Choi BH, Suzuki M, Kim T, Wagner SL, Cunningham DD. PMID: 2221008; PMCID: PMC1877547.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    29. Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor. J Biol Chem. 1990 Jun 15; 265(17):9591-4. Van Nostrand WE, Wagner SL, Farrow JS, Cunningham DD. PMID: 2112543.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    30. Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein. Science. 1990 May 11; 248(4956):745-8. Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD. PMID: 2110384.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    31. Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J Neurochem. 1990 May; 54(5):1735-43. Cavanaugh KP, Gurwitz D, Cunningham DD, Bradshaw RA. PMID: 1691280.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    32. Neurite outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibition. J Cell Physiol. 1990 Jan; 142(1):155-62. Gurwitz D, Cunningham DD. PMID: 2298818.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    33. Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Proc Natl Acad Sci U S A. 1989 Nov; 86(21):8284-8. Wagner SL, Geddes JW, Cotman CW, Lau AL, Gurwitz D, Isackson PJ, Cunningham DD. PMID: 2813392; PMCID: PMC298265.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    34. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature. 1989 Oct 12; 341(6242):546-9. Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD. PMID: 2507928.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    35. Protease nexin-1 complexes and inhibits T cell serine proteinase-1. Biochem Biophys Res Commun. 1989 May 30; 161(1):300-4. Gurwitz D, Simon MM, Fruth U, Cunningham DD. PMID: 2786418.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. Binding of protease nexin-1 to the fibroblast surface alters its target proteinase specificity. J Biol Chem. 1989 Jan 05; 264(1):611-5. Wagner SL, Lau AL, Cunningham DD. PMID: 2642483.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    37. Proteolytic regulation of neurite outgrowth from neuroblastoma cells by thrombin and protease nexin-1. J Cell Biochem. 1989 Jan; 39(1):55-64. Cunningham DD, Gurwitz D. PMID: 2654147.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    38. Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc Natl Acad Sci U S A. 1988 May; 85(10):3440-4. Gurwitz D, Cunningham DD. PMID: 2835773; PMCID: PMC280227.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    39. Purification of a form of protease nexin 1 that binds heparin with a low affinity. Biochemistry. 1988 Mar 22; 27(6):2176-81. Van Nostrand WE, Wagner SL, Cunningham DD. PMID: 3378053.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    40. Monoclonal antibodies to protease nexin 1 that differentially block its inhibition of target proteases. Biochemistry. 1988 Mar 22; 27(6):2173-6. Wagner SL, Van Nostrand WE, Lau AL, Cunningham DD. PMID: 3378052.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    41. Functional and structural similarities between protease nexin I and C1 inhibitor. J Biol Chem. 1988 Mar 15; 263(8):3979-83. Van Nostrand WE, McKay LD, Baker JB, Cunningham DD. PMID: 3279027.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    42. Effects of fibroblasts and endothelial cells on inactivation of target proteases by protease nexin-1, heparin cofactor II, and C1-inhibitor. J Cell Biochem. 1988 Mar; 36(3):199-207. Hiramoto SA, Cunningham DD. PMID: 3379101.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    43. Localization of protease nexin-1 on the fibroblast extracellular matrix. J Cell Physiol. 1988 Feb; 134(2):179-88. Farrell DH, Wagner SL, Yuan RH, Cunningham DD. PMID: 3279057.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    44. Glycosaminoglycans on fibroblasts accelerate thrombin inhibition by protease nexin-1. Biochem J. 1987 Jul 15; 245(2):543-50. Farrell DH, Cunningham DD. PMID: 2959275; PMCID: PMC1148156.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
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