Gary Lynch

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-0276
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    Collapse Research 
    Collapse Research Activities and Funding
    Postnatal Oxytocin Treatment and Cognitive Function in Fragile X
    NIH R01HD101642Apr 5, 2021 - Mar 31, 2026
    Role: Co-Principal Investigator
    Epigenetic mechanisms in the medial habenula governing drug-seeking behavior
    NIH R01DA047441Jul 15, 2020 - Apr 30, 2025
    Role: Co-Principal Investigator
    Loss and rescue of endocannabinoid-dependent LTP and memory in Fragile-X model mice
    NIH R01HD089491Sep 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Convergent Synaptic Mechanisms in Neurodevelopmental Disorders
    NIH R01NS085709Sep 1, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Role of neuron-specific nucleosome remodeling in intellectual disability
    NIH R01MH101491Jul 5, 2013 - Apr 30, 2019
    Role: Co-Principal Investigator
    Kinase Inhibitors against Neurodegeneration
    NIH R41NS047759Jun 1, 2004 - May 31, 2006
    Role: Principal Investigator
    Integrin and LTP Consolidation
    NIH R01MH061007Aug 10, 2001 - Jul 31, 2004
    Role: Principal Investigator
    Integrins and LTP consolidation
    NIH R01NS051823Dec 1, 1999 - May 31, 2010
    Role: Principal Investigator
    PLASTICITY OF HIPPOCAMPAL SYNAPSES
    NIH K05MH000358Jul 1, 1981 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Contributions of site- and sex-specific LTPs to everyday memory. Philos Trans R Soc Lond B Biol Sci. 2024 Jul 29; 379(1906):20230223. Gall CM, Le AA, Lynch G. PMID: 38853551; PMCID: PMC11343211.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. Sex differences in the context dependency of episodic memory. Front Behav Neurosci. 2024; 18:1349053. Le AA, Palmer LC, Chavez J, Gall CM, Lynch G. PMID: 38516050; PMCID: PMC10956361.
      View in: PubMed   Mentions: 1  
    3. Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory. bioRxiv. 2024 Jan 27. Le AA, Lauterborn JC, Jia Y, Cox CD, Lynch G, Gall CM. PMID: 38328108; PMCID: PMC10849651.
      View in: PubMed   Mentions:
    4. Novel types of frequency filtering in the lateral perforant path projections to dentate gyrus. J Physiol. 2022 08; 600(16):3865-3896. Quintanilla J, Jia Y, Lauterborn JC, Pruess BS, Le AA, Cox CD, Gall CM, Lynch G, Gunn BG. PMID: 35852108; PMCID: PMC9513824.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases. Nat Neurosci. 2022 02; 25(2):180-190. Le AA, Lauterborn JC, Jia Y, Wang W, Cox CD, Gall CM, Lynch G. PMID: 35087246; PMCID: PMC8876130.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    6. Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents. Neurobiol Dis. 2022 01; 162:105565. Le AA, Quintanilla J, Amani M, Piomelli D, Lynch G, Gall CM. PMID: 34838664; PMCID: PMC10249649.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease. Nat Commun. 2021 05 10; 12(1):2603. Lauterborn JC, Scaduto P, Cox CD, Schulmann A, Lynch G, Gall CM, Keene CD, Limon A. PMID: 33972518; PMCID: PMC8110554.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    8. Sex differences in synaptic plasticity underlying learning. J Neurosci Res. 2023 05; 101(5):764-782. Gall CM, Le AA, Lynch G. PMID: 33847004; PMCID: PMC10337639.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    9. Retrograde enhancement of episodic learning by a postlearning stimulus. Learn Mem. 2021 03; 28(3):82-86. Quintanilla J, Cox BM, Gall CM, Mahler SV, Lynch G. PMID: 33593926; PMCID: PMC7888236.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus. J Neurosci. 2021 03 10; 41(10):2301-2312. Amani M, Lauterborn JC, Le AA, Cox BM, Wang W, Quintanilla J, Cox CD, Gall CM, Lynch G. PMID: 33514675; PMCID: PMC8018768.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    11. Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease. Brain Pathol. 2020 03; 30(2):319-331. Lauterborn JC, Cox CD, Chan SW, Vanderklish PW, Lynch G, Gall CM. PMID: 31410926; PMCID: PMC7015764.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    12. A TrkB agonist and ampakine rescue synaptic plasticity and multiple forms of memory in a mouse model of intellectual disability. Neurobiol Dis. 2020 02; 134:104604. Seese RR, Le AA, Wang K, Cox CD, Lynch G, Gall CM. PMID: 31494285; PMCID: PMC7258745.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    13. Acquisition of temporal order requires an intact CA3 commissural/associational (C/A) feedback system in mice. Commun Biol. 2019; 2:251. Cox BM, Cox CD, Gunn BG, Le AA, Inshishian VC, Gall CM, Lynch G. PMID: 31286068; PMCID: PMC6610080.
      View in: PubMed   Mentions: 12  Translation:Animals
    14. Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities. Transl Psychiatry. 2019 06 10; 9(1):166. Lauterborn JC, Schultz MN, Le AA, Amani M, Friedman AE, Leach PT, Gall CM, Lynch GS, Crawley JN. PMID: 31182707; PMCID: PMC6557858.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    15. Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior. Neuropharmacology. 2019 07 15; 153:13-19. López AJ, Hemstedt TJ, Jia Y, Hwang PH, Campbell RR, Kwapis JL, White AO, Chitnis O, Scarfone VM, Matheos DP, Lynch G, Wood MA. PMID: 30998946; PMCID: PMC6581582.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus. J Neurosci. 2018 09 12; 38(37):7935-7951. Wang W, Le AA, Hou B, Lauterborn JC, Cox CD, Levin ER, Lynch G, Gall CM. PMID: 30209204; PMCID: PMC6136152.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    17. UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. Elife. 2018 07 18; 7. Sun J, Liu Y, Jia Y, Hao X, Lin WJ, Tran J, Lynch G, Baudry M, Bi X. PMID: 30020076; PMCID: PMC6063731.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    18. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cereb Cortex. 2018 07 01; 28(7):2253-2266. Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G. PMID: 28520937; PMCID: PMC5998949.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    19. Author Correction: Patch clamp-assisted single neuron lipidomics. Sci Rep. 2018 Apr 25; 8(1):6772. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. PMID: 29691427; PMCID: PMC5915401.
      View in: PubMed   Mentions:    Fields:    
    20. Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents. Toxicol Sci. 2018 04 01; 162(2):383-395. Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, Cook J, Garman RH, Jortner B, Bolon B, Radin D, Lippa A. PMID: 29253237.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior. Addict Biol. 2019 05; 24(3):403-413. López AJ, Jia Y, White AO, Kwapis JL, Espinoza M, Hwang P, Campbell R, Alaghband Y, Chitnis O, Matheos DP, Lynch G, Wood MA. PMID: 29430793; PMCID: PMC6087687.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    22. Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. Mol Psychiatry. 2018 08; 23(8):1798-1806. Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G. PMID: 29133950; PMCID: PMC5951717.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    23. Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus. Learn Mem. 2017 11; 24(11):569-579. Cox CD, Palmer LC, Pham DT, Trieu BH, Gall CM, Lynch G. PMID: 29038218; PMCID: PMC5647927.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Patch clamp-assisted single neuron lipidomics. Sci Rep. 2017 07 13; 7(1):5318. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. PMID: 28706218; PMCID: PMC5509708.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus. Cereb Cortex. 2017 04 01; 27(4):2640-2651. Lauterborn JC, Kramár EA, Rice JD, Babayan AH, Cox CD, Karsten CA, Gall CM, Lynch G. PMID: 27073215; PMCID: PMC5964364.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    26. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. J Neurosci. 2017 02 01; 37(5):1197-1212. Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW. PMID: 27986924; PMCID: PMC5296796.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    27. Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. J Neurosci. 2016 11 02; 36(44):11295-11307. Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ. PMID: 27807170; PMCID: PMC5148245.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    28. A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. eNeuro. 2016 Jul-Aug; 3(4). Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G. PMID: 27517090; PMCID: PMC4976302.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    29. Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon β1-integrin function. Neuropsychopharmacology. 2016 10; 41(11):2723-32. Wang W, Kantorovich S, Babayan AH, Hou B, Gall CM, Lynch G. PMID: 27272766; PMCID: PMC5026741.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats. J Neurosci. 2016 Feb 03; 36(5):1636-46. Lauterborn JC, Palmer LC, Jia Y, Pham DT, Hou B, Wang W, Trieu BH, Cox CD, Kantorovich S, Gall CM, Lynch G. PMID: 26843645; PMCID: PMC4737774.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    31. Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia. Mol Neuropsychiatry. 2015 Dec; 1(4):201-19. Hjelm BE, Rollins B, Mamdani F, Lauterborn JC, Kirov G, Lynch G, Gall CM, Sequeira A, Vawter MP. PMID: 26550561; PMCID: PMC4635522.
      View in: PubMed   Mentions: 50  
    32. Pronounced differences in signal processing and synaptic plasticity between piriform-hippocampal network stages: a prominent role for adenosine. J Physiol. 2015 Jul 01; 593(13):2889-907. Trieu BH, Kramár EA, Cox CD, Jia Y, Wang W, Gall CM, Lynch G. PMID: 25902928; PMCID: PMC4506187.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    33. Brain and memory: Old arguments and new perspectives. Brain Res. 2015 Sep 24; 1621:1-4. Lynch G, Baudry M. PMID: 25557403.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Protein synthesis and consolidation of memory-related synaptic changes. Brain Res. 2015 Sep 24; 1621:62-72. Lynch G, Kramár EA, Gall CM. PMID: 25485773.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    35. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16907-12. Seese RR, Wang K, Yao YQ, Lynch G, Gall CM. PMID: 25385607; PMCID: PMC4250145.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    36. Pharmacological enhancement of memory or cognition in normal subjects. Front Syst Neurosci. 2014; 8:90. Lynch G, Cox CD, Gall CM. PMID: 24904313; PMCID: PMC4033242.
      View in: PubMed   Mentions: 22  
    37. A map of LTP-related synaptic changes in dorsal hippocampus following unsupervised learning. J Neurosci. 2014 Feb 19; 34(8):3033-41. Cox CD, Rex CS, Palmer LC, Babayan AH, Pham DT, Corwin SD, Trieu BH, Gall CM, Lynch G. PMID: 24553943; PMCID: PMC3931507.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells. Stem Cells Transl Med. 2014 Apr; 3(4):424-32. Riazifar H, Jia Y, Chen J, Lynch G, Huang T. PMID: 24493857; PMCID: PMC3973714.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCellsCTClinical Trials
    39. Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism. Neuropsychopharmacology. 2014 Jun; 39(7):1664-73. Seese RR, Maske AR, Lynch G, Gall CM. PMID: 24448645; PMCID: PMC4023139.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    40. Human cortical θ during free exploration encodes space and predicts subsequent memory. J Neurosci. 2013 Sep 18; 33(38):15056-68. Snider J, Plank M, Lynch G, Halgren E, Poizner H. PMID: 24048836; PMCID: PMC3776058.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    41. Mechanism based approaches for rescuing and enhancing cognition. Front Neurosci. 2013; 7:143. Lynch G, Gall CM. PMID: 23966908; PMCID: PMC3744010.
      View in: PubMed   Mentions: 17  
    42. Synaptic abnormalities in the infralimbic cortex of a model of congenital depression. J Neurosci. 2013 Aug 14; 33(33):13441-8. Seese RR, Chen LY, Cox CD, Schulz D, Babayan AH, Bunney WE, Henn FA, Gall CM, Lynch G. PMID: 23946402; PMCID: PMC3742930.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    43. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013 May; 16(5):552-61. Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. PMID: 23525042; PMCID: PMC3777648.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    44. Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase. J Neurosci. 2012 Dec 05; 32(49):17714-24. Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW. PMID: 23223292; PMCID: PMC3687587.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    45. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012 Sep 12; 32(37):12854-61. Babayan AH, Kramár EA, Barrett RM, Jafari M, Häettig J, Chen LY, Rex CS, Lauterborn JC, Wood MA, Gall CM, Lynch G. PMID: 22973009; PMCID: PMC3752079.
      View in: PubMed   Mentions: 56     Fields:    Translation:Animals
    46. Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation. Neuropharmacology. 2013 Jan; 64:27-36. Lynch G, Kramár EA, Babayan AH, Rumbaugh G, Gall CM. PMID: 22820276; PMCID: PMC3445784.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    47. LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice. J Neurosci. 2012 May 23; 32(21):7403-13. Seese RR, Babayan AH, Katz AM, Cox CD, Lauterborn JC, Lynch G, Gall CM. PMID: 22623686; PMCID: PMC3365659.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    48. Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome. Neurobiol Dis. 2012 Aug; 47(2):210-5. Baudry M, Kramar E, Xu X, Zadran H, Moreno S, Lynch G, Gall C, Bi X. PMID: 22525571; PMCID: PMC3367059.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    49. Synaptic evidence for the efficacy of spaced learning. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5121-6. Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G, Lynch G. PMID: 22411798; PMCID: PMC3323981.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    50. Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology. 2011 Jul; 36(8):1545-56. Barrett RM, Malvaez M, Kramar E, Matheos DP, Arrizon A, Cabrera SM, Lynch G, Greene RW, Wood MA. PMID: 21508930; PMCID: PMC3138668.
      View in: PubMed   Mentions: 136     Fields:    Translation:Animals
    51. The likelihood of cognitive enhancement. Pharmacol Biochem Behav. 2011 Aug; 99(2):116-29. Lynch G, Palmer LC, Gall CM. PMID: 21215768; PMCID: PMC3114293.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    52. The biochemistry of memory: The 26year journey of a 'new and specific hypothesis'. Neurobiol Learn Mem. 2011 Feb; 95(2):125-33. Baudry M, Bi X, Gall C, Lynch G. PMID: 21134478; PMCID: PMC3042723.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    53. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10; 30(45):15097-101. Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. PMID: 21068315; PMCID: PMC3073526.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    54. Presynaptic BDNF promotes postsynaptic long-term potentiation in the dorsal striatum. J Neurosci. 2010 Oct 27; 30(43):14440-5. Jia Y, Gall CM, Lynch G. PMID: 20980601; PMCID: PMC2972744.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    55. Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice. Neurobiol Dis. 2011 Feb; 41(2):436-44. Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G. PMID: 20977939; PMCID: PMC3014441.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    56. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci. 2010 Sep 29; 30(39):13005-15. Ivy AS, Rex CS, Chen Y, Dubé C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ. PMID: 20881118; PMCID: PMC2991143.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansAnimalsCells
    57. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. Neuron. 2010 Aug 26; 67(4):603-17. Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G. PMID: 20797537; PMCID: PMC2929390.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    58. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010 Aug 18; 30(33):10977-84. Chen LY, Rex CS, Babayan AH, Kramár EA, Lynch G, Gall CM, Lauterborn JC. PMID: 20720104; PMCID: PMC2929244.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    59. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol Aging. 2012 Apr; 33(4):708-19. Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G. PMID: 20674095; PMCID: PMC2978788.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    60. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13123-8. Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, Baram TZ. PMID: 20615973; PMCID: PMC2919915.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    61. Neuroscience. A Kantian view of space. Science. 2010 Jun 18; 328(5985):1487-8. Palmer L, Lynch G. PMID: 20558692.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    62. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):7030-5. Chen LY, Rex CS, Sanaiha Y, Lynch G, Gall CM. PMID: 20356829; PMCID: PMC2872439.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    63. Origins of an intrinsic hippocampal EEG pattern. PLoS One. 2009 Nov 11; 4(11):e7761. Rex CS, Colgin LL, Jia Y, Casale M, Yanagihara TK, Debenedetti M, Gall CM, Kramar EA, Lynch G. PMID: 19907647; PMCID: PMC2770848.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    64. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009 Oct 14; 29(41):12982-93. Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. PMID: 19828812; PMCID: PMC2806054.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    65. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009 Jul 13; 186(1):85-97. Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM, Lynch G. PMID: 19596849; PMCID: PMC2712993.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    66. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4906-11. Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G. PMID: 19264961; PMCID: PMC2660722.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    67. Estrogen's Place in the Family of Synaptic Modulators. Mol Cell Pharmacol. 2009 Jan 01; 1(5):258-262. Kramár EA, Chen LY, Rex CS, Gall CM, Lynch G. PMID: 20419049; PMCID: PMC2858427.
      View in: PubMed   Mentions: 21  
    68. Auditory evoked potential abnormalities in cluster headache. Neuroreport. 2008 Oct 29; 19(16):1633-6. Casale MS, Baratto M, Cervera C, Gallamini M, Lynch G, Gjini K, Boutros NN. PMID: 18845943.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    69. The substrates of memory: defects, treatments, and enhancement. Eur J Pharmacol. 2008 May 06; 585(1):2-13. Lynch G, Rex CS, Chen LY, Gall CM. PMID: 18374328; PMCID: PMC2427007.
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    71. Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease. Glia. 2007 Aug 01; 55(10):1074-84. Simmons DA, Casale M, Alcon B, Pham N, Narayan N, Lynch G. PMID: 17551926.
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    77. Synaptic plasticity in early aging. Ageing Res Rev. 2006 Aug; 5(3):255-80. Lynch G, Rex CS, Gall CM. PMID: 16935034.
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    78. Ampakines and the threefold path to cognitive enhancement. Trends Neurosci. 2006 Oct; 29(10):554-62. Lynch G, Gall CM. PMID: 16890999.
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    81. Glutamate-based therapeutic approaches: ampakines. Curr Opin Pharmacol. 2006 Feb; 6(1):82-8. Lynch G. PMID: 16361116.
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    82. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain. Am J Pathol. 2005 Oct; 167(4):1081-92. Bi X, Liu J, Yao Y, Baudry M, Lynch G. PMID: 16192643; PMCID: PMC1603683.
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    83. Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices. Neurosci Lett. 2005 Sep 02; 385(1):46-51. Colgin LL, Jia Y, Sabatier JM, Lynch G. PMID: 15927372.
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    86. Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology. J Neurochem. 2005 May; 93(4):834-49. Bernard-Trifilo JA, Kramár EA, Torp R, Lin CY, Pineda EA, Lynch G, Gall CM. PMID: 15857387.
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    89. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. J Biol Chem. 2004 Nov 12; 279(46):48238-45. Bi X, Baudry M, Liu J, Yao Y, Fu L, Brucher F, Lynch G. PMID: 15364922.
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    90. Spontaneous waves in the dentate gyrus of slices from the ventral hippocampus. J Neurophysiol. 2004 Dec; 92(6):3385-98. Colgin LL, Kubota D, Brucher FA, Jia Y, Branyan E, Gall CM, Lynch G. PMID: 15282260.
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    95. Integrins, synaptic plasticity and epileptogenesis. Adv Exp Med Biol. 2004; 548:12-33. Gall CM, Lynch G. PMID: 15250583.
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    96. Lysosomes and brain aging in mammals. Neurochem Res. 2003 Nov; 28(11):1725-34. Lynch G, Bi X. PMID: 14584826.
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    98. Chronic elevation of brain-derived neurotrophic factor by ampakines. J Pharmacol Exp Ther. 2003 Oct; 307(1):297-305. Lauterborn JC, Truong GS, Baudry M, Bi X, Lynch G, Gall CM. PMID: 12893840.
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    99. Septal modulation of excitatory transmission in hippocampus. J Neurophysiol. 2003 Oct; 90(4):2358-66. Colgin LL, Kramár EA, Gall CM, Lynch G. PMID: 12840078.
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    100. Integrins regulate NMDA receptor-mediated synaptic currents. J Neurophysiol. 2003 May; 89(5):2874-8. Lin B, Arai AC, Lynch G, Gall CM. PMID: 12740418.
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    101. Long-term potentiation in the Eocene. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29; 358(1432):625-8. Lynch G. PMID: 12740106; PMCID: PMC1693157.
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    102. Integrins modulate fast excitatory transmission at hippocampal synapses. J Biol Chem. 2003 Mar 21; 278(12):10722-30. Kramár EA, Bernard JA, Gall CM, Lynch G. PMID: 12524441.
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    103. Endogenous waves in hippocampal slices. J Neurophysiol. 2003 Jan; 89(1):81-9. Kubota D, Colgin LL, Casale M, Brucher FA, Lynch G. PMID: 12522161.
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    104. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec; 303(3):1075-85. Arai AC, Xia YF, Rogers G, Lynch G, Kessler M. PMID: 12438530.
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    105. Interactions between recording technique and AMPA receptor modulators. Brain Res. 2002 Nov 15; 955(1-2):164-73. Lin B, Colgin LL, Brücher FA, Arai AC, Lynch G. PMID: 12419533.
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    106. Memory enhancement: the search for mechanism-based drugs. Nat Neurosci. 2002 Nov; 5 Suppl:1035-8. Lynch G. PMID: 12403980.
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    107. Identification of diagnostic evoked response potential segments in Alzheimer's disease. Exp Neurol. 2002 Aug; 176(2):269-76. Benvenuto J, Jin Y, Casale M, Lynch G, Granger R. PMID: 12359169.
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    108. Long-term potentiation alters the modulator pharmacology of AMPA-type glutamate receptors. J Neurophysiol. 2002 Jun; 87(6):2790-800. Lin B, Brücher FA, Colgin LL, Lynch G. PMID: 12037181.
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    109. 5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity. Bioorg Med Chem. 2002 May; 10(5):1229-48. Phillips D, Sonnenberg J, Arai AC, Vaswani R, Krutzik PO, Kleisli T, Kessler M, Granger R, Lynch G, Richard Chamberlin A. PMID: 11886787.
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    110. Antagonists of the Platelet-activating Factor Receptor Block Long-term Potentiation in Hippocampal Slices. Eur J Neurosci. 1992; 4(5):411-419. Arai A, Lynch G. PMID: 12106349.
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