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Lynch, Gary

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentPsychiatry and Human Behavior
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-0276
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    Collapse Research 
    Collapse Research Activities and Funding
    Loss and rescue of endocannabinoid-dependent LTP and memory in Fragile-X model mice
    NIH/NICHD R01HD089491Sep 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Convergent Synaptic Mechanisms in Neurodevelopmental Disorders
    NIH/NINDS R01NS085709Sep 1, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Role of neuron-specific nucleosome remodeling in intellectual disability
    NIH/NIMH R01MH101491Jul 5, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Kinase Inhibitors against Neurodegeneration
    NIH/NINDS R41NS047759Jun 1, 2004 - May 31, 2006
    Role: Principal Investigator
    Integrin and LTP Consolidation
    NIH/NIMH R01MH061007Aug 10, 2001 - Jul 31, 2004
    Role: Principal Investigator
    Integrins and LTP consolidation
    NIH/NINDS R01NS051823Dec 1, 1999 - May 31, 2010
    Role: Principal Investigator
    PLASTICITY OF HIPPOCAMPAL SYNAPSES
    NIH/NIMH K05MH000358Jul 1, 1981 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang W, Le AA, Hou B, Lauterborn JC, Cox CD, Levin ER, Lynch G, Gall CM. Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus. J Neurosci. 2018 Sep 12; 38(37):7935-7951. PMID: 30209204.
      View in: PubMed
    2. Sun J, Liu Y, Jia Y, Hao X, Lin WJ, Tran J, Lynch G, Baudry M, Bi X. UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. Elife. 2018 Jul 18; 7. PMID: 30020076.
      View in: PubMed
    3. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. Author Correction: Patch clamp-assisted single neuron lipidomics. Sci Rep. 2018 Apr 25; 8(1):6772. PMID: 29691427.
      View in: PubMed
    4. Purcell R, Lynch G, Gall C, Johnson S, Sheng Z, Stephen MR, Cook J, Garman RH, Jortner B, Bolon B, Radin D, Lippa A. Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents. Toxicol Sci. 2018 Apr 01; 162(2):383-395. PMID: 29253237.
      View in: PubMed
    5. López AJ, Jia Y, White AO, Kwapis JL, Espinoza M, Hwang P, Campbell R, Alaghband Y, Chitnis O, Matheos DP, Lynch G, Wood MA. Medial habenula cholinergic signaling regulates cocaine-associated relapse-like behavior. Addict Biol. 2018 Feb 12. PMID: 29430793.
      View in: PubMed
    6. Wang W, Cox BM, Jia Y, Le AA, Cox CD, Jung KM, Hou B, Piomelli D, Gall CM, Lynch G. Treating a novel plasticity defect rescues episodic memory in Fragile X model mice. Mol Psychiatry. 2017 Nov 14. PMID: 29133950.
      View in: PubMed
    7. Cox CD, Palmer LC, Pham DT, Trieu BH, Gall CM, Lynch G. Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus. Learn Mem. 2017 Nov; 24(11):569-579. PMID: 29038218.
      View in: PubMed
    8. Merrill CB, Basit A, Armirotti A, Jia Y, Gall CM, Lynch G, Piomelli D. Patch clamp-assisted single neuron lipidomics. Sci Rep. 2017 Jul 13; 7(1):5318. PMID: 28706218.
      View in: PubMed
    9. Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cereb Cortex. 2017 May 17; 1-14. PMID: 28520937.
      View in: PubMed
    10. Vogel Ciernia A, Kramár EA, Matheos DP, Havekes R, Hemstedt TJ, Magnan CN, Sakata K, Tran A, Azzawi S, Lopez A, Dang R, Wang W, Trieu B, Tong J, Barrett RM, Post RJ, Baldi P, Abel T, Lynch G, Wood MA. Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling. Learn Mem. 2017 05; 24(5):199-209. PMID: 28416631.
      View in: PubMed
    11. Lauterborn JC, Kramár EA, Rice JD, Babayan AH, Cox CD, Karsten CA, Gall CM, Lynch G. Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus. Cereb Cortex. 2017 04 01; 27(4):2640-2651. PMID: 27073215.
      View in: PubMed
    12. Prieto GA, Trieu BH, Dang CT, Bilousova T, Gylys KH, Berchtold NC, Lynch G, Cotman CW. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. J Neurosci. 2017 Feb 01; 37(5):1197-1212. PMID: 27986924.
      View in: PubMed
    13. Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ. Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. J Neurosci. 2016 Nov 02; 36(44):11295-11307. PMID: 27807170.
      View in: PubMed
    14. Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G. A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27517090; PMCID: PMC4976302.
    15. Wang W, Kantorovich S, Babayan AH, Hou B, Gall CM, Lynch G. Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon ß1-integrin function. Neuropsychopharmacology. 2016 10; 41(11):2723-32. PMID: 27272766; PMCID: PMC5026741 [Available on 10/01/17].
    16. Lauterborn JC, Palmer LC, Jia Y, Pham DT, Hou B, Wang W, Trieu BH, Cox CD, Kantorovich S, Gall CM, Lynch G. Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats. J Neurosci. 2016 Feb 03; 36(5):1636-46. PMID: 26843645; PMCID: PMC4737774.
    17. Hjelm BE, Rollins B, Mamdani F, Lauterborn JC, Kirov G, Lynch G, Gall CM, Sequeira A, Vawter MP. Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia. Mol Neuropsychiatry. 2015 Dec; 1(4):201-19. PMID: 26550561; PMCID: PMC4635522 [Available on 12/01/16].
    18. Trieu BH, Kramár EA, Cox CD, Jia Y, Wang W, Gall CM, Lynch G. Pronounced differences in signal processing and synaptic plasticity between piriform-hippocampal network stages: a prominent role for adenosine. J Physiol. 2015 Jul 01; 593(13):2889-907. PMID: 25902928; PMCID: PMC4506187.
    19. Lynch G, Baudry M. Brain and memory: Old arguments and new perspectives. Brain Res. 2015 Sep 24; 1621:1-4. PMID: 25557403.
      View in: PubMed
    20. Lynch G, Kramár EA, Gall CM. Protein synthesis and consolidation of memory-related synaptic changes. Brain Res. 2015 Sep 24; 1621:62-72. PMID: 25485773.
      View in: PubMed
    21. Seese RR, Wang K, Yao YQ, Lynch G, Gall CM. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16907-12. PMID: 25385607; PMCID: PMC4250145.
    22. Ozkan ED, Creson TK, Kramár EA, Rojas C, Seese RR, Babyan AH, Shi Y, Lucero R, Xu X, Noebels JL, Miller CA, Lynch G, Rumbaugh G. Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron. 2014 Jun 18; 82(6):1317-33. PMID: 24945774; PMCID: PMC4104574.
    23. Lynch G, Cox CD, Gall CM. Pharmacological enhancement of memory or cognition in normal subjects. Front Syst Neurosci. 2014; 8:90. PMID: 24904313; PMCID: PMC4033242.
    24. Sejnowski TJ, Poizner H, Lynch G, Gepshtein S, Greenspan RJ. Prospective Optimization. Proc IEEE Inst Electr Electron Eng. 2014 May; 102(5). PMID: 25328167.
      View in: PubMed
    25. Cox CD, Rex CS, Palmer LC, Babayan AH, Pham DT, Corwin SD, Trieu BH, Gall CM, Lynch G. A map of LTP-related synaptic changes in dorsal hippocampus following unsupervised learning. J Neurosci. 2014 Feb 19; 34(8):3033-41. PMID: 24553943; PMCID: PMC3931507.
    26. Riazifar H, Jia Y, Chen J, Lynch G, Huang T. Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells. Stem Cells Transl Med. 2014 Apr; 3(4):424-32. PMID: 24493857; PMCID: PMC3973714.
    27. Seese RR, Maske AR, Lynch G, Gall CM. Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism. Neuropsychopharmacology. 2014 Jun; 39(7):1664-73. PMID: 24448645; PMCID: PMC4023139.
    28. Snider J, Plank M, Lynch G, Halgren E, Poizner H. Human cortical ? during free exploration encodes space and predicts subsequent memory. J Neurosci. 2013 Sep 18; 33(38):15056-68. PMID: 24048836; PMCID: PMC3776058.
    29. Lynch G, Gall CM. Mechanism based approaches for rescuing and enhancing cognition. Front Neurosci. 2013; 7:143. PMID: 23966908; PMCID: PMC3744010.
    30. Seese RR, Chen LY, Cox CD, Schulz D, Babayan AH, Bunney WE, Henn FA, Gall CM, Lynch G. Synaptic abnormalities in the infralimbic cortex of a model of congenital depression. J Neurosci. 2013 Aug 14; 33(33):13441-8. PMID: 23946402; PMCID: PMC3742930.
    31. Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013 May; 16(5):552-61. PMID: 23525042; PMCID: PMC3777648.
    32. Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW. Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1ß via p38 mitogen-activated protein kinase. J Neurosci. 2012 Dec 05; 32(49):17714-24. PMID: 23223292; PMCID: PMC3687587.
    33. Babayan AH, Kramár EA, Barrett RM, Jafari M, Häettig J, Chen LY, Rex CS, Lauterborn JC, Wood MA, Gall CM, Lynch G. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012 Sep 12; 32(37):12854-61. PMID: 22973009; PMCID: PMC3752079.
    34. Lynch G, Kramár EA, Babayan AH, Rumbaugh G, Gall CM. Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation. Neuropharmacology. 2013 Jan; 64:27-36. PMID: 22820276; PMCID: PMC3445784.
    35. Seese RR, Babayan AH, Katz AM, Cox CD, Lauterborn JC, Lynch G, Gall CM. LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice. J Neurosci. 2012 May 23; 32(21):7403-13. PMID: 22623686; PMCID: PMC3365659.
    36. Baudry M, Kramar E, Xu X, Zadran H, Moreno S, Lynch G, Gall C, Bi X. Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome. Neurobiol Dis. 2012 Aug; 47(2):210-5. PMID: 22525571; PMCID: PMC3367059.
    37. Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G, Lynch G. Synaptic evidence for the efficacy of spaced learning. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5121-6. PMID: 22411798; PMCID: PMC3323981.
    38. Barrett RM, Malvaez M, Kramar E, Matheos DP, Arrizon A, Cabrera SM, Lynch G, Greene RW, Wood MA. Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology. 2011 Jul; 36(8):1545-56. PMID: 21508930; PMCID: PMC3138668.
    39. Clarkson AN, Overman JJ, Zhong S, Mueller R, Lynch G, Carmichael ST. AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke. J Neurosci. 2011 Mar 09; 31(10):3766-75. PMID: 21389231; PMCID: PMC4698878.
    40. Lynch G, Palmer LC, Gall CM. The likelihood of cognitive enhancement. Pharmacol Biochem Behav. 2011 Aug; 99(2):116-29. PMID: 21215768; PMCID: PMC3114293.
    41. Baudry M, Bi X, Gall C, Lynch G. The biochemistry of memory: The 26year journey of a 'new and specific hypothesis'. Neurobiol Learn Mem. 2011 Feb; 95(2):125-33. PMID: 21134478; PMCID: PMC3042723.
    42. Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10; 30(45):15097-101. PMID: 21068315; PMCID: PMC3073526.
    43. Jia Y, Gall CM, Lynch G. Presynaptic BDNF promotes postsynaptic long-term potentiation in the dorsal striatum. J Neurosci. 2010 Oct 27; 30(43):14440-5. PMID: 20980601; PMCID: PMC2972744.
    44. Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G. Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice. Neurobiol Dis. 2011 Feb; 41(2):436-44. PMID: 20977939; PMCID: PMC3014441.
    45. Ivy AS, Rex CS, Chen Y, Dubé C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ. Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci. 2010 Sep 29; 30(39):13005-15. PMID: 20881118; PMCID: PMC2991143.
    46. Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. Neuron. 2010 Aug 26; 67(4):603-17. PMID: 20797537; PMCID: PMC2929390.
    47. Chen LY, Rex CS, Babayan AH, Kramár EA, Lynch G, Gall CM, Lauterborn JC. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010 Aug 18; 30(33):10977-84. PMID: 20720104; PMCID: PMC2929244.
    48. Kramár EA, Chen LY, Lauterborn JC, Simmons DA, Gall CM, Lynch G. BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol Aging. 2012 Apr; 33(4):708-19. PMID: 20674095; PMCID: PMC2978788.
    49. Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, Baram TZ. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13123-8. PMID: 20615973; PMCID: PMC2919915.
    50. Palmer L, Lynch G. Neuroscience. A Kantian view of space. Science. 2010 Jun 18; 328(5985):1487-8. PMID: 20558692.
      View in: PubMed
    51. Chen LY, Rex CS, Sanaiha Y, Lynch G, Gall CM. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):7030-5. PMID: 20356829; PMCID: PMC2872439.
    52. Rex CS, Colgin LL, Jia Y, Casale M, Yanagihara TK, Debenedetti M, Gall CM, Kramar EA, Lynch G. Origins of an intrinsic hippocampal EEG pattern. PLoS One. 2009 Nov 11; 4(11):e7761. PMID: 19907647; PMCID: PMC2770848.
    53. Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009 Oct 14; 29(41):12982-93. PMID: 19828812; PMCID: PMC2806054.
    54. Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM, Lynch G. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009 Jul 13; 186(1):85-97. PMID: 19596849; PMCID: PMC2712993.
    55. Simmons DA, Rex CS, Palmer L, Pandyarajan V, Fedulov V, Gall CM, Lynch G. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4906-11. PMID: 19264961; PMCID: PMC2660722.
    56. Kramár EA, Chen LY, Rex CS, Gall CM, Lynch G. Estrogen's Place in the Family of Synaptic Modulators. Mol Cell Pharmacol. 2009 Jan 01; 1(5):258-262. PMID: 20419049.
      View in: PubMed
    57. Casale MS, Baratto M, Cervera C, Gallamini M, Lynch G, Gjini K, Boutros NN. Auditory evoked potential abnormalities in cluster headache. Neuroreport. 2008 Oct 29; 19(16):1633-6. PMID: 18845943.
      View in: PubMed
    58. Lynch G, Rex CS, Chen LY, Gall CM. The substrates of memory: defects, treatments, and enhancement. Eur J Pharmacol. 2008 May 06; 585(1):2-13. PMID: 18374328; PMCID: PMC2427007.
    59. Lauterborn JC, Rex CS, Kramár E, Chen LY, Pandyarajan V, Lynch G, Gall CM. Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J Neurosci. 2007 Oct 03; 27(40):10685-94. PMID: 17913902.
      View in: PubMed
    60. Simmons DA, Casale M, Alcon B, Pham N, Narayan N, Lynch G. Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease. Glia. 2007 Aug 01; 55(10):1074-84. PMID: 17551926.
      View in: PubMed
    61. Fedulov V, Rex CS, Simmons DA, Palmer L, Gall CM, Lynch G. Evidence that long-term potentiation occurs within individual hippocampal synapses during learning. J Neurosci. 2007 Jul 25; 27(30):8031-9. PMID: 17652593.
      View in: PubMed
    62. Chen LY, Rex CS, Casale MS, Gall CM, Lynch G. Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 2007 May 16; 27(20):5363-72. PMID: 17507558.
      View in: PubMed
    63. Lynch G, Kramar EA, Rex CS, Jia Y, Chappas D, Gall CM, Simmons DA. Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J Neurosci. 2007 Apr 18; 27(16):4424-34. PMID: 17442827.
      View in: PubMed
    64. Rex CS, Lin CY, Kramár EA, Chen LY, Gall CM, Lynch G. Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. J Neurosci. 2007 Mar 14; 27(11):3017-29. PMID: 17360925.
      View in: PubMed
    65. Lynch G, Rex CS, Gall CM. LTP consolidation: substrates, explanatory power, and functional significance. Neuropharmacology. 2007 Jan; 52(1):12-23. PMID: 16949110.
      View in: PubMed
    66. Lynch G, Rex CS, Gall CM. Synaptic plasticity in early aging. Ageing Res Rev. 2006 Aug; 5(3):255-80. PMID: 16935034.
      View in: PubMed
    67. Lynch G, Gall CM. Ampakines and the threefold path to cognitive enhancement. Trends Neurosci. 2006 Oct; 29(10):554-62. PMID: 16890999.
      View in: PubMed
    68. Rex CS, Lauterborn JC, Lin CY, Kramár EA, Rogers GA, Gall CM, Lynch G. Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor. J Neurophysiol. 2006 Aug; 96(2):677-85. PMID: 16707719; PMCID: PMC1554892.
    69. Kramár EA, Lin B, Rex CS, Gall CM, Lynch G. Integrin-driven actin polymerization consolidates long-term potentiation. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5579-84. PMID: 16567651; PMCID: PMC1459396.
    70. Lynch G. Glutamate-based therapeutic approaches: ampakines. Curr Opin Pharmacol. 2006 Feb; 6(1):82-8. PMID: 16361116.
      View in: PubMed
    71. Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ. Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci. 2005 Oct 12; 25(41):9328-38. PMID: 16221841; PMCID: PMC3100717.
    72. Bi X, Liu J, Yao Y, Baudry M, Lynch G. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain. Am J Pathol. 2005 Oct; 167(4):1081-92. PMID: 16192643; PMCID: PMC1603683.
    73. Colgin LL, Jia Y, Sabatier JM, Lynch G. Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices. Neurosci Lett. 2005 Sep 02; 385(1):46-51. PMID: 15927372.
      View in: PubMed
    74. Lin CY, Lynch G, Gall CM. AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling. J Neurochem. 2005 Jul; 94(2):531-46. PMID: 16000124; PMCID: PMC2366053.
    75. Rex CS, Kramár EA, Colgin LL, Lin B, Gall CM, Lynch G. Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists. J Neurosci. 2005 Jun 22; 25(25):5956-66. PMID: 15976084.
      View in: PubMed
    76. Bernard-Trifilo JA, Kramár EA, Torp R, Lin CY, Pineda EA, Lynch G, Gall CM. Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology. J Neurochem. 2005 May; 93(4):834-49. PMID: 15857387.
      View in: PubMed
    77. Lin B, Kramár EA, Bi X, Brucher FA, Gall CM, Lynch G. Theta stimulation polymerizes actin in dendritic spines of hippocampus. J Neurosci. 2005 Feb 23; 25(8):2062-9. PMID: 15728846.
      View in: PubMed
    78. Jourdi H, Yanagihara T, Martinez U, Bi X, Lynch G, Baudry M. Effects of positive AMPA receptor modulators on calpain-mediated spectrin degradation in cultured hippocampal slices. Neurochem Int. 2005 Jan; 46(1):31-40. PMID: 15567513.
      View in: PubMed
    79. Bi X, Baudry M, Liu J, Yao Y, Fu L, Brucher F, Lynch G. Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. J Biol Chem. 2004 Nov 12; 279(46):48238-45. PMID: 15364922.
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    80. Colgin LL, Kubota D, Brucher FA, Jia Y, Branyan E, Gall CM, Lynch G. Spontaneous waves in the dentate gyrus of slices from the ventral hippocampus. J Neurophysiol. 2004 Dec; 92(6):3385-98. PMID: 15282260.
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    81. Colgin LL, Kubota D, Jia Y, Rex CS, Lynch G. Long-term potentiation is impaired in rat hippocampal slices that produce spontaneous sharp waves. J Physiol. 2004 Aug 01; 558(Pt 3):953-61. PMID: 15194734; PMCID: PMC1665012.
    82. Kramár EA, Lin B, Lin CY, Arai AC, Gall CM, Lynch G. A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J Neurosci. 2004 Jun 02; 24(22):5151-61. PMID: 15175384.
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    83. Lynch G. AMPA receptor modulators as cognitive enhancers. Curr Opin Pharmacol. 2004 Feb; 4(1):4-11. PMID: 15018832.
      View in: PubMed
    84. Díaz-Cintra S, Yong A, Aguilar A, Bi X, Lynch G, Ribak CE. Ultrastructural analysis of hippocampal pyramidal neurons from apolipoprotein E-deficient mice treated with a cathepsin inhibitor. J Neurocytol. 2004 Jan; 33(1):37-48. PMID: 15173631.
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    85. Gall CM, Lynch G. Integrins, synaptic plasticity and epileptogenesis. Adv Exp Med Biol. 2004; 548:12-33. PMID: 15250583.
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    86. Lynch G, Bi X. Lysosomes and brain aging in mammals. Neurochem Res. 2003 Nov; 28(11):1725-34. PMID: 14584826.
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    87. Bi X, Head E, Cotman CW, Lynch G. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. PMID: 12900930.
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    88. Lauterborn JC, Truong GS, Baudry M, Bi X, Lynch G, Gall CM. Chronic elevation of brain-derived neurotrophic factor by ampakines. J Pharmacol Exp Ther. 2003 Oct; 307(1):297-305. PMID: 12893840.
      View in: PubMed
    89. Colgin LL, Kramár EA, Gall CM, Lynch G. Septal modulation of excitatory transmission in hippocampus. J Neurophysiol. 2003 Oct; 90(4):2358-66. PMID: 12840078.
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    90. Lin B, Arai AC, Lynch G, Gall CM. Integrins regulate NMDA receptor-mediated synaptic currents. J Neurophysiol. 2003 May; 89(5):2874-8. PMID: 12740418.
      View in: PubMed
    91. Lynch G. Long-term potentiation in the Eocene. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29; 358(1432):625-8. PMID: 12740106; PMCID: PMC1693157.
    92. Colgin LL, Kubota D, Lynch G. Cholinergic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2872-7. PMID: 12591947; PMCID: PMC151433.
    93. Kramár EA, Bernard JA, Gall CM, Lynch G. Integrins modulate fast excitatory transmission at hippocampal synapses. J Biol Chem. 2003 Mar 21; 278(12):10722-30. PMID: 12524441.
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    94. Kubota D, Colgin LL, Casale M, Brucher FA, Lynch G. Endogenous waves in hippocampal slices. J Neurophysiol. 2003 Jan; 89(1):81-9. PMID: 12522161.
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    95. Arai AC, Xia YF, Rogers G, Lynch G, Kessler M. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec; 303(3):1075-85. PMID: 12438530.
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    96. Lin B, Colgin LL, Brücher FA, Arai AC, Lynch G. Interactions between recording technique and AMPA receptor modulators. Brain Res. 2002 Nov 15; 955(1-2):164-73. PMID: 12419533.
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