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Yassa, Michael A.

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentNeurobiology & Behavior
Address213 Qureshey Research Lab
Zot 3800
Irvine CA 92697
Phone(949) 824-1687
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    Collapse Research 
    Collapse Research Activities and Funding
    International Conference on Learning and Memory
    NIH/NINDS R13NS106922Apr 1, 2018 - Mar 31, 2019
    Role: Principal Investigator
    Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathology
    NIH/NIA R01AG053555Jul 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Selective age-related vulnerability in human perirhinal and lateral entorhinal cortices
    NIH/NIA R21AG049220Sep 15, 2015 - May 31, 2017
    Role: Principal Investigator
    Neural Mechanisms of Emotional Memory Modulation in Major Depression
    NIH/NIMH R01MH102392Sep 5, 2014 - Jul 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Suwabe K, Byun K, Hyodo K, Reagh ZM, Roberts JM, Matsushita A, Saotome K, Ochi G, Fukuie T, Suzuki K, Sankai Y, Yassa MA, Soya H. Rapid stimulation of human dentate gyrus function with acute mild exercise. Proc Natl Acad Sci U S A. 2018 Sep 24. PMID: 30249651.
      View in: PubMed
    2. Stevenson RF, Zheng J, Mnatsakanyan L, Vadera S, Knight RT, Lin JJ, Yassa MA. Hippocampal CA1 gamma power predicts the precision of spatial memory judgments. Proc Natl Acad Sci U S A. 2018 Sep 17. PMID: 30224452.
      View in: PubMed
    3. Sinha N, Berg CN, Tustison NJ, Shaw A, Hill D, Yassa MA, Gluck MA. APOE e4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation. Neurobiol Aging. 2018 May 26; 69:221-229. PMID: 29909179.
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    4. Risbrough VB, Glynn LM, Davis EP, Sandman CA, Obenaus A, Stern HS, Keator DB, Yassa MA, Baram TZ, Baker DG. Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? : Adolescent Anhedonia and Posttraumatic Disorders. Curr Top Behav Neurosci. 2018 May 24. PMID: 29796839.
      View in: PubMed
    5. Reagh ZM, Noche JA, Tustison NJ, Delisle D, Murray EA, Yassa MA. Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits. Neuron. 2018 Mar 07; 97(5):1187-1198.e4. PMID: 29518359.
      View in: PubMed
    6. Leal SL, Yassa MA. Integrating new findings and examining clinical applications of pattern separation. Nat Neurosci. 2018 Feb; 21(2):163-173. PMID: 29371654.
      View in: PubMed
    7. Yassa MA. Brain Rhythms: Higher-Frequency Theta Oscillations Make Sense in Moving Humans. Curr Biol. 2018 Jan 22; 28(2):R70-R72. PMID: 29374447.
      View in: PubMed
    8. Moran MS, Zhao Y, Ma S, Kirova Y, Fourquet A, Chen P, Hoffman K, Hunt K, Wong J, Halasz LM, Freedman G, Prosnitz R, Yassa M, Nguyen DHA, Hijal T, Haffty BG, Wai ES, Truong PT. Association of Radiotherapy Boost for Ductal Carcinoma In Situ With Local Control After Whole-Breast Radiotherapy. JAMA Oncol. 2017 Aug 01; 3(8):1060-1068. PMID: 28358936.
      View in: PubMed
    9. Suwabe K, Hyodo K, Byun K, Ochi G, Fukuie T, Shimizu T, Kato M, Yassa MA, Soya H. Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: evidence for memory flexibility in young adults. Sci Rep. 2017 Jul 11; 7(1):5140. PMID: 28698596.
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    10. Stark SM, Reagh ZM, Yassa MA, Stark CEL. What's in a context? Cautions, limitations, and potential paths forward. Neurosci Lett. 2017 May 18. PMID: 28529173.
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    11. Tiberi D, Vavassis P, Nguyen D, Yassa M. Hypofractionation for prostate cancer: an update. Expert Rev Endocrinol Metab. 2017 May; 12(3):199-205. PMID: 30063454.
      View in: PubMed
    12. Reagh Z, Yassa M. Selective vulnerabilities and biomarkers in neurocognitive aging. F1000Res. 2017; 6:491. PMID: 28491288.
      View in: PubMed
    13. Kraguljac NV, Carle M, Frölich MA, Tran S, Yassa MA, White DM, Reddy A, Lahti AC. Mnemonic Discrimination Deficits in First-Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to N-Methyl-D-Aspartate Receptor Hypofunction. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Mar; 3(3):231-238. PMID: 29486864.
      View in: PubMed
    14. Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW. Pattern separation and goal-directed behavior in the aged canine. Learn Mem. 2017 03; 24(3):123-131. PMID: 28202716.
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    15. Zheng J, Anderson KL, Leal SL, Shestyuk A, Gulsen G, Mnatsakanyan L, Vadera S, Hsu FP, Yassa MA, Knight RT, Lin JJ. Amygdala-hippocampal dynamics during salient information processing. Nat Commun. 2017 Feb 08; 8:14413. PMID: 28176756.
      View in: PubMed
    16. Leal SL, Noche JA, Murray EA, Yassa MA. Disruption of amygdala-entorhinal-hippocampal network in late-life depression. Hippocampus. 2017 04; 27(4):464-476. PMID: 28085210.
      View in: PubMed
    17. Suwabe K, Hyodo K, Byun K, Ochi G, Yassa MA, Soya H. Acute moderate exercise improves mnemonic discrimination in young adults. Hippocampus. 2017 Mar; 27(3):229-234. PMID: 27997992.
      View in: PubMed
    18. Reagh ZM, Murray EA, Yassa MA. Repetition reveals ups and downs of hippocampal, thalamic, and neocortical engagement during mnemonic decisions. Hippocampus. 2017 02; 27(2):169-183. PMID: 27859884.
      View in: PubMed
    19. Wisse LEM, Daugherty AM, Olsen RK, Berron D, Carr VA, Stark CEL, Amaral RSC, Amunts K, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren A, Chakravarty MM, Chupin M, Ekstrom A, de Flores R, Insausti R, Kanel P, Kedo O, Kennedy KM, Kerchner GA, LaRocque KF, Liu X, Maass A, Malykhin N, Mueller SG, Ofen N, Palombo DJ, Parekh MB, Pluta JB, Pruessner JC, Raz N, Rodrigue KM, Schoemaker D, Shafer AT, Steve TA, Suthana N, Wang L, Winterburn JL, Yassa MA, Yushkevich PA, la Joie R. A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus. 2017 01; 27(1):3-11. PMID: 27862600.
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    20. Leal SL, Noche JA, Murray EA, Yassa MA. Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation. Neurobiol Aging. 2017 01; 49:9-19. PMID: 27723500.
      View in: PubMed
    21. Leal SL, Noche JA, Murray EA, Yassa MA. Positivity effect specific to older adults with subclinical memory impairment. Learn Mem. 2016 08; 23(8):415-21. PMID: 27421893.
      View in: PubMed
    22. Reagh ZM, Ho HD, Leal SL, Noche JA, Chun A, Murray EA, Yassa MA. Greater loss of object than spatial mnemonic discrimination in aged adults. Hippocampus. 2016 Apr; 26(4):417-22. PMID: 26691235.
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    23. Leal SL, Yassa MA. Neurocognitive Aging and the Hippocampus across Species. Trends Neurosci. 2015 Dec; 38(12):800-812. PMID: 26607684.
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    24. Cunningham CA, Yassa MA, Egeth HE. Massive memory revisited: Limitations on storage capacity for object details in visual long-term memory. Learn Mem. 2015 Nov; 22(11):563-6. PMID: 26472646; PMCID: PMC4749727 [Available on 11/01/16].
    25. Chang A, Murray E, Yassa MA. Mnemonic discrimination of similar face stimuli and a potential mechanism for the "other race" effect. Behav Neurosci. 2015 Oct; 129(5):666-72. PMID: 26413724.
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    26. Bahig H, Roussin É, Yassa M, Vavassis P, Lemaire C, Archambault L, Nguyen DH. Partial kilovoltage cone beam computed tomography, complete kilovoltage cone beam computed tomography, and electronic portal images for breast radiation therapy: A dose-comparison study. Pract Radiat Oncol. 2015 Sep-Oct; 5(5):e521-9. PMID: 25823380.
      View in: PubMed
    27. Yushkevich PA, Amaral RS, Augustinack JC, Bender AR, Bernstein JD, Boccardi M, Bocchetta M, Burggren AC, Carr VA, Chakravarty MM, Chételat G, Daugherty AM, Davachi L, Ding SL, Ekstrom A, Geerlings MI, Hassan A, Huang Y, Iglesias JE, La Joie R, Kerchner GA, LaRocque KF, Libby LA, Malykhin N, Mueller SG, Olsen RK, Palombo DJ, Parekh MB, Pluta JB, Preston AR, Pruessner JC, Ranganath C, Raz N, Schlichting ML, Schoemaker D, Singh S, Stark CE, Suthana N, Tompary A, Turowski MM, Van Leemput K, Wagner AD, Wang L, Winterburn JL, Wisse LE, Yassa MA, Zeineh MM. Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol. Neuroimage. 2015 May 01; 111:526-41. PMID: 25596463.
      View in: PubMed
    28. Anderson BA, Leal SL, Hall MG, Yassa MA, Yantis S. The attribution of value-based attentional priority in individuals with depressive symptoms. Cogn Affect Behav Neurosci. 2014 Dec; 14(4):1221-7. PMID: 24874421; PMCID: PMC4221358.
    29. Reagh ZM, Watabe J, Ly M, Murray E, Yassa MA. Dissociated signals in human dentate gyrus and CA3 predict different facets of recognition memory. J Neurosci. 2014 Oct 01; 34(40):13301-13. PMID: 25274810; PMCID: PMC4180469.
    30. Reagh ZM, Yassa MA. Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):E4264-73. PMID: 25246569; PMCID: PMC4210036.
    31. Leal SL, Yassa MA. Effects of aging on mnemonic discrimination of emotional information. Behav Neurosci. 2014 Oct; 128(5):539-47. PMID: 25150544; PMCID: PMC4196942.
    32. Reagh ZM, Yassa MA. Repetition strengthens target recognition but impairs similar lure discrimination: evidence for trace competition. Learn Mem. 2014 Jul; 21(7):342-6. PMID: 24934334; PMCID: PMC4061427.
    33. Roberts JM, Ly M, Murray E, Yassa MA. Temporal discrimination deficits as a function of lag interference in older adults. Hippocampus. 2014 Oct; 24(10):1189-96. PMID: 24811482.
      View in: PubMed
    34. Leal SL, Tighe SK, Jones CK, Yassa MA. Pattern separation of emotional information in hippocampal dentate and CA3. Hippocampus. 2014 Sep; 24(9):1146-55. PMID: 24796287; PMCID: PMC4172604.
    35. Leal SL, Tighe SK, Yassa MA. Asymmetric effects of emotion on mnemonic interference. Neurobiol Learn Mem. 2014 May; 111:41-8. PMID: 24607286; PMCID: PMC4194069.
    36. Yassa MA. Ground zero in Alzheimer's disease. Nat Neurosci. 2014 Feb; 17(2):146-7. PMID: 24473258.
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    37. Borota D, Murray E, Keceli G, Chang A, Watabe JM, Ly M, Toscano JP, Yassa MA. Post-study caffeine administration enhances memory consolidation in humans. Nat Neurosci. 2014 Feb; 17(2):201-3. PMID: 24413697.
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    38. Anderson BA, Leal SL, Hall MG, Yassa MA, Yantis S. The Attribution of Value-Based Attentional Priority in Individuals with Depressive Symptoms. Vis cogn. 2014; 22(8):1014-1017. PMID: 25642133.
      View in: PubMed
    39. Yassa M, Vavassis P, Niazi T. Whole-pelvic radiation therapy in the context of hypofractionation for high-risk prostate cancer patients: a step forward. In regard to Kaidar-Person et al. Int J Radiat Oncol Biol Phys. 2013 Nov 15; 87(4):634-5. PMID: 24138911.
      View in: PubMed
    40. Reagh ZM, Roberts JM, Ly M, DiProspero N, Murray E, Yassa MA. Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment. Hippocampus. 2014 Mar; 24(3):303-14. PMID: 24167060; PMCID: PMC3968903.
    41. Hathout L, Hijal T, Théberge V, Fortin B, Vulpe H, Hogue JC, Lambert C, Bahig H, Provencher L, Vavassis P, Yassa M. Hypofractionated radiation therapy for breast ductal carcinoma in situ. Int J Radiat Oncol Biol Phys. 2013 Dec 01; 87(5):1058-63. PMID: 24113057.
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    42. Yassa MA, Reagh ZM. Competitive Trace Theory: A Role for the Hippocampus in Contextual Interference during Retrieval. Front Behav Neurosci. 2013; 7:107. PMID: 23964216; PMCID: PMC3740479.
    43. Ly M, Murray E, Yassa MA. Perceptual versus conceptual interference and pattern separation of verbal stimuli in young and older adults. Hippocampus. 2013 Jun; 23(6):425-30. PMID: 23505005; PMCID: PMC3968906.
    44. Kim J, Yassa MA. Assessing recollection and familiarity of similar lures in a behavioral pattern separation task. Hippocampus. 2013 Apr; 23(4):287-94. PMID: 23401187; PMCID: PMC4172605.
    45. Leal SL, Yassa MA. Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer's disease. Ageing Res Rev. 2013 Jun; 12(3):823-31. PMID: 23380151; PMCID: PMC3893046.
    46. Stark SM, Yassa MA, Lacy JW, Stark CE. A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment. Neuropsychologia. 2013 Oct; 51(12):2442-9. PMID: 23313292; PMCID: PMC3675184.
    47. Vavassis P, Nguyen DH, Bahary JP, Yassa M. Hypofractionated radiotherapy in prostate cancer. Expert Rev Anticancer Ther. 2012 Jul; 12(7):965-72. PMID: 22845411.
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    48. Bakker A, Krauss GL, Albert MS, Speck CL, Jones LR, Stark CE, Yassa MA, Bassett SS, Shelton AL, Gallagher M. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron. 2012 May 10; 74(3):467-74. PMID: 22578498; PMCID: PMC3351697.
    49. Yassa MA, Hazlett RL, Stark CE, Hoehn-Saric R. Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder. J Psychiatr Res. 2012 Aug; 46(8):1045-52. PMID: 22575329; PMCID: PMC3893050.
    50. Segal SK, Stark SM, Kattan D, Stark CE, Yassa MA. Norepinephrine-mediated emotional arousal facilitates subsequent pattern separation. Neurobiol Learn Mem. 2012 May; 97(4):465-9. PMID: 22498686; PMCID: PMC3517207.
    51. Giraud P, Kantor G, Yassa M, Zefkili S, Dejean C, Lisbona A, Campana F, Mahé MA. Two-year clinical experience with tomotherapy: the French national cancer institute project on implementing new technology. Cancer Invest. 2011 Oct; 29(8):557-63. PMID: 21843049.
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    52. Yassa MA, Stark CE. Pattern separation in the hippocampus. Trends Neurosci. 2011 Oct; 34(10):515-25. PMID: 21788086; PMCID: PMC3183227.
    53. Sylvestre A, Mahé MA, Lisbona A, Zefkili S, Savignoni A, Bonnette P, Barthes Fle P, Paris E, Perigaud C, Yassa M, Giraud P. Mesothelioma at era of helical tomotherapy: results of two institutions in combining chemotherapy, surgery and radiotherapy. Lung Cancer. 2011 Dec; 74(3):486-91. PMID: 21663996.
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    54. Yassa MA, Mattfeld AT, Stark SM, Stark CE. Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8873-8. PMID: 21555581; PMCID: PMC3102362.
    55. Yassa MA. Searching for novel biomarkers using high resolution diffusion tensor imaging. J Alzheimers Dis. 2011; 26 Suppl 3:297-305. PMID: 21971469.
      View in: PubMed
    56. Lacy JW, Yassa MA, Stark SM, Muftuler LT, Stark CE. Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn Mem. 2011 Jan; 18(1):15-8. PMID: 21164173; PMCID: PMC3023966.
    57. Yassa MA, Muftuler LT, Stark CE. Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12687-91. PMID: 20616040; PMCID: PMC2906542.
    58. Stark SM, Yassa MA, Stark CE. Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learn Mem. 2010 Jun; 17(6):284-8. PMID: 20495062; PMCID: PMC2884287.
    59. Yassa MA, Lacy JW, Stark SM, Albert MS, Gallagher M, Stark CE. Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus. 2011 Sep; 21(9):968-79. PMID: 20865732; PMCID: PMC3010452.
    60. Yassa MA, Stark SM, Bakker A, Albert MS, Gallagher M, Stark CE. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment. Neuroimage. 2010 Jul 01; 51(3):1242-52. PMID: 20338246; PMCID: PMC2909476.
    61. Bonekamp D, Yassa MA, Munro CA, Geckle RJ, Yousem DM, Barker PB, Schretlen DJ, Brandt J, Horská A. Gray matter in amnestic mild cognitive impairment: voxel-based morphometry. Neuroreport. 2010 Mar 10; 21(4):259-63. PMID: 20042900; PMCID: PMC3041512.
    62. Cuzzocreo JL, Yassa MA, Verduzco G, Honeycutt NA, Scott DJ, Bassett SS. Effect of handedness on fMRI activation in the medial temporal lobe during an auditory verbal memory task. Hum Brain Mapp. 2009 Apr; 30(4):1271-8. PMID: 18570207; PMCID: PMC2672821.
    63. Yassa MA, Stark CE. A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe. Neuroimage. 2009 Jan 15; 44(2):319-27. PMID: 18929669.
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    64. Yassa MA, Verduzco G, Cristinzio C, Bassett SS. Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease. Neurology. 2008 May 13; 70(20):1898-904. PMID: 18474845; PMCID: PMC2671804.
    65. Yassa M, Fortin B, Fortin MA, Lambert C, Van Nguyen T, Bahary JP. Combined hypofractionated radiation and hormone therapy for the treatment of intermediate-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2008 May 01; 71(1):58-63. PMID: 18406883.
      View in: PubMed
    66. Yassa MA, Stark CE. Multiple signals of recognition memory in the medial temporal lobe. Hippocampus. 2008; 18(9):945-54. PMID: 18493928.
      View in: PubMed
    67. Bazin PL, Cuzzocreo JL, Yassa MA, Gandler W, McAuliffe MJ, Bassett SS, Pham DL. Volumetric neuroimage analysis extensions for the MIPAV software package. J Neurosci Methods. 2007 Sep 15; 165(1):111-21. PMID: 17604116; PMCID: PMC2017110.
    68. Bassett SS, Yousem DM, Cristinzio C, Kusevic I, Yassa MA, Caffo BS, Zeger SL. Familial risk for Alzheimer's disease alters fMRI activation patterns. Brain. 2006 May; 129(Pt 5):1229-39. PMID: 16627465; PMCID: PMC2744898.
    69. Reading SA, Yassa MA, Bakker A, Dziorny AC, Gourley LM, Yallapragada V, Rosenblatt A, Margolis RL, Aylward EH, Brandt J, Mori S, van Zijl P, Bassett SS, Ross CA. Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study. Psychiatry Res. 2005 Oct 30; 140(1):55-62. PMID: 16199141.
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    70. Assaf M, Rivkin PR, Kuzu CH, Calhoun VD, Kraut MA, Groth KM, Yassa MA, Hart J, Pearlson GD. Abnormal object recall and anterior cingulate overactivation correlate with formal thought disorder in schizophrenia. Biol Psychiatry. 2006 Mar 01; 59(5):452-9. PMID: 16199012.
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    71. Yassa M, Bahary JP, Bourguoin P, Bélair M, Berthelet F, Bouthillier A. Intra-parenchymal mesenchymal chondrosarcoma of the cerebellum: case report and review of the literature. J Neurooncol. 2005 Sep; 74(3):329-31. PMID: 16187026.
      View in: PubMed
    72. Bassett SS, Kusevic I, Cristinzio C, Yassa MA, Avramopoulos D, Yousem DM, Fallin MD. Brain activation in offspring of AD cases corresponds to 10q linkage. Ann Neurol. 2005 Jul; 58(1):142-6. PMID: 15984011; PMCID: PMC2672820.
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