Amal Alachkar

Title(s)Senior Lecturer, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-2591
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ophthalmate is a new regulator of motor functions via CaSR: implications for movement disorders. Brain. 2024 Oct 03; 147(10):3379-3394. Alhassen S, Hogenkamp D, Nguyen HA, Al Masri S, Abbott GW, Civelli O, Alachkar A. PMID: 38537648; PMCID: PMC11449132.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Circadian cilia transcriptome in mouse brain across physiological and pathological states. Mol Brain. 2024 Sep 20; 17(1):67. Chen K, Ashtiani KC, Monfared RV, Baldi P, Alachkar A. PMID: 39304885; PMCID: PMC11414107.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Humanized dopamine D4.7 receptor male mice display risk-taking behavior and deficits of social recognition and working memory in light/dark-dependent manner. J Neurosci Res. 2024 02; 102(2):e25299. Alachkar A, Phan A, Dabbous T, Alhassen S, Alhassen W, Reynolds B, Rubinstein M, Ferré S, Civelli O. PMID: 38361407; PMCID: PMC11503891.
      View in: PubMed   Mentions: 1     Fields:    
    4. Untargeted metabolomics analysis on kidney tissues from mice reveals potential hypoxia biomarkers. Sci Rep. 2023 10 16; 13(1):17516. Sajid MI, Nunez FJ, Amirrad F, Roosan MR, Vojtko T, McCulloch S, Alachkar A, Nauli SM. PMID: 37845304; PMCID: PMC10579359.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Reanalysis of primate brain circadian transcriptomics reveals connectivity-related oscillations. iScience. 2023 Oct 20; 26(10):107810. Lee J, Chen S, Monfared RV, Derdeyn P, Leong K, Chang T, Beier K, Baldi P, Alachkar A. PMID: 37752952; PMCID: PMC10518731.
      View in: PubMed   Mentions: 1  
    6. Spatiotemporal Mapping of Brain Cilia Reveals Region-Specific Oscillation of Length and Orientation. bioRxiv. 2023 Jul 15. Monfared RV, Abdelkarim S, Derdeyn P, Chen K, Wu H, Leong K, Chang T, Lee J, Versales S, Nauli S, Beier K, Baldi P, Alachkar A. PMID: 37425809; PMCID: PMC10326993.
      View in: PubMed   Mentions:
    7. Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice. Front Mol Neurosci. 2023; 16:1192628. Chen KJ, Yoshimura R, Edmundo CA, Truong TM, Civelli O, Alachkar A, Abbott GW. PMID: 37305551; PMCID: PMC10248464.
      View in: PubMed   Mentions: 1  
    8. Cilia in the Striatum Mediate Timing-Dependent Functions. Mol Neurobiol. 2023 Feb; 60(2):545-565. Alhassen W, Alhassen S, Chen J, Monfared RV, Alachkar A. PMID: 36322337; PMCID: PMC9849326.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. Aromatic patterns: Tryptophan aromaticity as a catalyst for the emergence of life and rise of consciousness. Phys Life Rev. 2022 09; 42:93-114. Alachkar A. PMID: 35905538.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. The hidden link between circadian entropy and mental health disorders. Transl Psychiatry. 2022 07 14; 12(1):281. Alachkar A, Lee J, Asthana K, Vakil Monfared R, Chen J, Alhassen S, Samad M, Wood M, Mayer EA, Baldi P. PMID: 35835742; PMCID: PMC9283542.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    11. Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation. Neurobiol Dis. 2022 09; 171:105799. Ramamoorthy K, Yoshimura R, Al-Juburi S, Anandam KY, Kapadia R, Alachkar A, Abbott GW, Said HM. PMID: 35750148; PMCID: PMC9744268.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. L-methionine enhances neuroinflammation and impairs neurogenesis: Implication for Alzheimer's disease. J Neuroimmunol. 2022 05 15; 366:577843. Alachkar A, Agrawal S, Baboldashtian M, Nuseir K, Salazar J, Agrawal A. PMID: 35299077.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Lab-In-A-Syringe: A Novel Electrochemical Biosensor for On-Site and Real-Time Monitoring of Dopamine in Freely Behaving Mice. ACS Sens. 2022 01 28; 7(1):331-337. Alachkar A, Alhassan S, Senel M. PMID: 35006681.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer's associated proteins. Commun Integr Biol. 2021; 14(1):264-269. Mohieldin AM, Alachkar A, Yates J, Nauli SM. PMID: 34992713; PMCID: PMC8726672.
      View in: PubMed   Mentions: 6  
    15. Surface Plasmon Resonance Identifies High-Affinity Binding of l-DOPA to Siderocalin/Lipocalin-2 through Iron-Siderophore Action: Implications for Parkinson's Disease Treatment. ACS Chem Neurosci. 2022 01 05; 13(1):158-165. Alhassen S, Senel M, Alachkar A. PMID: 34939797.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions. Cells. 2021 10 31; 10(11). Monfared RV, Alhassen W, Truong TM, Gonzales MAM, Vachirakorntong V, Chen S, Baldi P, Civelli O, Alachkar A. PMID: 34831190; PMCID: PMC8616384.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations. Mol Neurobiol. 2022 Jan; 59(1):245-265. Alhassen W, Kobayashi Y, Su J, Robbins B, Nguyen H, Myint T, Yu M, Nauli SM, Saito Y, Alachkar A. PMID: 34665407; PMCID: PMC9083846.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    18. Dynamic Changes of Brain Cilia Transcriptomes across the Human Lifespan. Int J Mol Sci. 2021 Sep 27; 22(19). Chen S, Alhassen W, Vakil Monfared R, Vachirakorntong B, Nauli SM, Baldi P, Alachkar A. PMID: 34638726; PMCID: PMC8509004.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Large-scale analysis reveals spatiotemporal circadian patterns of cilia transcriptomes in the primate brain. J Neurosci Res. 2021 10; 99(10):2610-2624. Baldi P, Alhassen W, Chen S, Nguyen H, Khoudari M, Alachkar A. PMID: 34310750; PMCID: PMC11391745.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Age-Related Neurometabolomic Signature of Mouse Brain. ACS Chem Neurosci. 2021 08 04; 12(15):2887-2902. Chen S, Lee J, Truong TM, Alhassen S, Baldi P, Alachkar A. PMID: 34283556.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction. Commun Biol. 2021 06 24; 4(1):783. Alhassen S, Chen S, Alhassen L, Phan A, Khoudari M, De Silva A, Barhoosh H, Wang Z, Parrocha C, Shapiro E, Henrich C, Wang Z, Mutesa L, Baldi P, Abbott GW, Alachkar A. PMID: 34168265; PMCID: PMC8225861.
      View in: PubMed   Mentions: 11  Translation:HumansAnimalsCells
    22. Patterns of cilia gene dysregulations in major psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2021 07 13; 109:110255. Alhassen W, Chen S, Vawter M, Robbins BK, Nguyen H, Myint TN, Saito Y, Schulmann A, Nauli SM, Civelli O, Baldi P, Alachkar A. PMID: 33508383; PMCID: PMC9121176.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level. Lab Chip. 2021 01 21; 21(2):405-411. Senel M, Alachkar A. PMID: 33331378.
      View in: PubMed   Mentions: 5     Fields:    
    24. Oxytocin-MCH circuit regulates monosynaptic inputs to MCH neurons and modulates social recognition memory. Neuropharmacology. 2021 02 15; 184:108423. Sanathara N, Alhassen L, Marmouzi I, Khoudari M, Phan J, Alhassen W, Civelli O, Alachkar A. PMID: 33290754.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    25. Microfluidic Electrochemical Sensor for Cerebrospinal Fluid and Blood Dopamine Detection in a Mouse Model of Parkinson's Disease. Anal Chem. 2020 09 15; 92(18):12347-12355. Senel M, Dervisevic E, Alhassen S, Dervisevic M, Alachkar A, Cadarso VJ, Voelcker NH. PMID: 32786441.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    26. Mating and parenting experiences sculpture mood-modulating effects of oxytocin-MCH signaling. Sci Rep. 2020 08 12; 10(1):13611. Phan J, Alhassen L, Argelagos A, Alhassen W, Vachirakorntong B, Lin Z, Sanathara N, Alachkar A. PMID: 32788646; PMCID: PMC7423941.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis. Commun Biol. 2020 07 30; 3(1):409. Chen S, Alhassen W, Yoshimura R, De Silva A, Abbott GW, Baldi P, Alachkar A. PMID: 32732995; PMCID: PMC7393105.
      View in: PubMed   Mentions: 6  Translation:HumansAnimalsCells
    28. Burden of post-traumatic stress disorder in postgenocide Rwandan population following exposure to 1994 genocide against the Tutsi: A meta-analysis. J Affect Disord. 2020 10 01; 275:7-13. Musanabaganwa C, Jansen S, Fatumo S, Rutembesa E, Mutabaruka J, Gishoma D, Uwineza A, Kayiteshonga Y, Alachkar A, Wildman D, Uddin M, Mutesa L. PMID: 32658827; PMCID: PMC7395874.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    29. Electrochemical Micropyramid Array-Based Sensor for In Situ Monitoring of Dopamine Released from Neuroblastoma Cells. Anal Chem. 2020 06 02; 92(11):7746-7753. Senel M, Dervisevic M, Alhassen S, Alachkar A, Voelcker NH. PMID: 32367711.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating. Int J Neuropsychopharmacol. 2020 03 10; 23(1):53-65. Vawter MP, Schulmann A, Alhassen L, Alhassen W, Hamzeh AR, Sakr J, Pauluk L, Yoshimura R, Wang X, Dai Q, Sanathara N, Civelli O, Alachkar A. PMID: 31563948; PMCID: PMC7442395.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    31. A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia. Neurochem Res. 2019 Nov; 44(11):2536-2545. Wang L, Zhang Y, Wang C, Zhang X, Wang Z, Liang X, Alachkar A, Civelli O. PMID: 31529334.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    32. Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies. Mol Neuropsychiatry. 2019 Oct; 5(4):200-211. Vawter MP, Hamzeh AR, Muradyan E, Civelli O, Abbott GW, Alachkar A. PMID: 31768373; PMCID: PMC6873027.
      View in: PubMed   Mentions: 8  
    33. The role of Olfaction in MCH-regulated spontaneous maternal responses. Brain Res. 2019 09 15; 1719:71-76. Alhassen L, Phan A, Alhassen W, Nguyen P, Lo A, Shaharuddin H, Sanathara N, Civelli O, Alachkar A. PMID: 31121161.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3. FASEB J. 2018 06; 32(6):3184-3192. Zhang Y, Liu Y, Wu L, Fan C, Wang Z, Zhang X, Alachkar A, Liang X, Civelli O. PMID: 29401613; PMCID: PMC5956246.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    35. Melanin concentrating hormone modulates oxytocin-mediated marble burying. Neuropharmacology. 2018 Jan; 128:22-32. Sanathara NM, Garau C, Alachkar A, Wang L, Wang Z, Nishimori K, Xu X, Civelli O. PMID: 28888943; PMCID: PMC5830107.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    36. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLoS One. 2016; 11(9):e0162875. Wang L, Zhang Y, Wang Z, Gong N, Kweon TD, Vo B, Wang C, Zhang X, Chung JY, Alachkar A, Liang X, Luo DZ, Civelli O. PMID: 27622550; PMCID: PMC5021270.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    37. Inactivation of the melanin concentrating hormone system impairs maternal behavior. Eur Neuropsychopharmacol. 2016 11; 26(11):1826-1835. Alachkar A, Alhassen L, Wang Z, Wang L, Onouye K, Sanathara N, Civelli O. PMID: 27617778; PMCID: PMC5929110.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    38. A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity. Int J Neuropsychopharmacol. 2015 May 19; 18(12). Wang L, Alachkar A, Sanathara N, Belluzzi JD, Wang Z, Civelli O. PMID: 25991655; PMCID: PMC4675974.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    39. High-Risk HPVs and Human Carcinomas in the Syrian Population. Front Oncol. 2014; 4:68. Al Moustafa AE, Ghabreau L, Akil N, Rastam S, Alachkar A, Yasmeen A. PMID: 24765613; PMCID: PMC3980109.
      View in: PubMed   Mentions: 12  
    40. Betaine significantly improves multiplex tetra-primer ARMS-PCR methods. Mol Biotechnol. 2013 Jul; 54(3):977-82. Lajin B, Alachkar A, Alhaj Sakur A. PMID: 23412968.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women. Breast Cancer Res Treat. 2013 Apr; 138(2):611-9. Lajin B, Alhaj Sakur A, Alachkar A. PMID: 23468244.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    42. Allele Frequencies of the Epidermal Growth Factor Receptors Polymorphism R521K in Colorectal Cancer Patients and Healthy Subjects Indicate a Risk-Reducing Effect of K521 in Syrian Population. N Am J Med Sci. 2013 Mar; 5(3):202-6. Mustafa OH, Hamzeh AR, Ghabreau L, Akil N, Almoustafa AE, Alachkar A. PMID: 23626956; PMCID: PMC3632024.
      View in: PubMed   Mentions: 3  
    43. Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort. Arch Med Res. 2013 Feb; 44(2):121-6. Lajin B, Alachkar A, Michati R, Alhaj Sakur A. PMID: 23360829.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. A quadruplex tetra-primer ARMS-PCR method for the simultaneous detection of TP53 Arg72Pro, IVS3 16bp Del/Ins and IVS6+62A>G, and NQO1 C609T polymorphisms. Gene. 2012 Aug 10; 504(2):268-73. Lajin B, Alachkar A, Alhaj Sakur A. PMID: 22633876.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    45. Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort. Asian J Psychiatr. 2012 Jun; 5(2):144-9. Lajin B, Alhaj Sakur A, Michati R, Alachkar A. PMID: 22813657.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    46. Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women. Tumour Biol. 2012 Aug; 33(4):1133-9. Lajin B, Alhaj Sakur A, Ghabreau L, Alachkar A. PMID: 22373582.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    47. Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria. Breast Cancer. 2013 Jan; 20(1):62-6. Lajin B, Hamzeh AR, Ghabreau L, Mohamed A, Al Moustafa AE, Alachkar A. PMID: 22124994.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    48. Triplex tetra-primer ARMS-PCR method for the simultaneous detection of MTHFR c.677C>T and c.1298A>C, and MTRR c.66A>G polymorphisms of the folate-homocysteine metabolic pathway. Mol Cell Probes. 2012 Feb; 26(1):16-20. Lajin B, Alachkar A, Sakur AA. PMID: 22074746.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    49. Src inhibitors are promising therapy molecules for human cervical carcinomas. Med Hypotheses. 2011 Nov; 77(5):812-4. Al Moustafa AE, Yasmeen A, Alachkar A, Achkhar A. PMID: 21864985.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    50. Changes in the mRNA levels of α2A and α2C adrenergic receptors in rat models of Parkinson's disease and L-DOPA-induced dyskinesia. J Mol Neurosci. 2012 Jan; 46(1):145-52. Alachkar A, Brotchie JM, Jones OT. PMID: 21562737.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    51. No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population. N Am J Med Sci. 2011 Apr; 3(4):176-8. Lajin B, Alachkar A, Hamzeh AR, Michati R, Alhaj H. PMID: 22540087; PMCID: PMC3336908.
      View in: PubMed   Mentions: 5  
    52. Traditional medicine in Syria: folk medicine in Aleppo governorate. Nat Prod Commun. 2011 Jan; 6(1):79-84. Alachkar A, Jaddouh A, Elsheikh MS, Bilia AR, Vincieri FF. PMID: 21366051.
      View in: PubMed   Mentions: 9     Fields:    
    53. Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV. J Oncol. 2010; 2010. Yasmeen A, Alachkar A, Dekhil H, Gambacorti-Passerini C, Al Moustafa AE. PMID: 20862378; PMCID: PMC2938462.
      View in: PubMed   Mentions: 17  
    54. Locomotor response to L-DOPA in reserpine-treated rats following central inhibition of aromatic L-amino acid decarboxylase: further evidence for non-dopaminergic actions of L-DOPA and its metabolites. Neurosci Res. 2010 Sep; 68(1):44-50. Alachkar A, Brotchie JM, Jones OT. PMID: 20542064.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    55. Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors. Neurosci Res. 2010 Jul; 67(3):245-9. Alachkar A, Brotchie JM, Jones OT. PMID: 20302892.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    56. Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex. J Ethnopharmacol. 2010 Jun 16; 129(3):410-5. Kandouz M, Alachkar A, Zhang L, Dekhil H, Chehna F, Yasmeen A, Al Moustafa AE. PMID: 19897022.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    57. alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata. Neurosci Lett. 2006 Mar 06; 395(2):138-42. Alachkar A, Brotchie J, Jones OT. PMID: 16356632.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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